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https://www.readbyqxmd.com/read/29792193/research-ethics-review-at-university-eduardo-mondlane-uem-maputo-central-hospital-mozambique-2013-2016-a-descriptive-analysis-of-the-start-up-of-a-new-research-ethics-committee-rec
#1
Jahit Sacarlal, Vasco Muchanga, Carlos Mabutana, Matilde Mabui, Arlete Mariamo, Assa Júlio Cuamba, Leida Artur Fumo, Jacinta Silveira, Elizabeth Heitman, Troy D Moon
BACKGROUND: Mozambique has seen remarkable growth in biomedical research over the last decade. To meet a growing need, the National Committee for Bioethics in Health of Mozambique (CNBS) encouraged the development of ethical review processes at institutions that regularly conduct medical and social science research. In 2012, the Faculty of Medicine (FM) of University Eduardo Mondlane (UEM) and the Maputo Central Hospital (MCH) established a joint Institutional Committee on Bioethics for Health (CIBS FM & MCH)...
May 23, 2018: BMC Medical Ethics
https://www.readbyqxmd.com/read/29792183/estimated-intraoperative-blood-loss-correlates-with-postoperative-cardiopulmonary-complications-and-length-of-stay-in-patients-undergoing-video-assisted-thoracoscopic-lung-cancer-lobectomy-a-retrospective-cohort-study
#2
Shuangjiang Li, Kun Zhou, Yutian Lai, Cheng Shen, Yanming Wu, Guowei Che
BACKGROUND: The purpose of our study was to estimate the influence of estimated intraoperative blood loss (EIBL) on postoperative cardiopulmonary complications (PCCs) in patients undergoing video-assisted thoracoscopic surgery (VATS) lobectomy for non-small-cell lung cancer (NSCLC). METHODS: We conducted a single-center retrospective analysis on the clinical data of consecutive patients in our institution between April 2015 and February 2016. Demographic differences between PCC group and non-PCC group were initially assessed...
May 23, 2018: BMC Surgery
https://www.readbyqxmd.com/read/29791887/long-term-no-tillage-application-increases-soil-organic-carbon-nitrous-oxide-emissions-and-faba-bean-vicia-faba-l-yields-under-rain-fed-mediterranean-conditions
#3
Giuseppe Badagliacca, Emilio Benítez, Gaetano Amato, Luigi Badalucco, Dario Giambalvo, Vito Armando Laudicina, Paolo Ruisi
The introduction of legumes into crop sequences and the reduction of tillage intensity are both proposed as agronomic practices to mitigate the soil degradation and negative impact of agriculture on the environment. However, the joint effects of these practices on nitrous oxide (N2 O) and ammonia (NH3 ) emissions from soil remain unclear, particularly concerning semiarid Mediterranean areas. In the frame of a long-term field experiment (23 years), a 2-year study was performed on the faba bean (Vicia faba L...
May 20, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29791703/biological-intercalary-reconstruction-with-bone-grafts-after-joint-sparing-resection-of-the-lower-limb-is-this-an-effective-and-durable-solution-for-joint-preservation
#4
Francesco Muratori, Francesca Totti, Antonio D'Arienzo, Maurizio Scorianz, Guido Scoccianti, Giovanni Beltrami, Francesco Rosario Campo, Carmine Citarelli, Rodolfo Capanna, Domenico Andrea Campanacci
Due to advances in neoadjuvant therapies and preoperative imaging modalities, joint-sparing resections have become appealing in bone tumor surgery. However, the intercalary reconstruction of metadiaphyseal bone defects of the femur and the tibia after juxta-articular tumor resection remains challenging. Both biological and prosthetic reconstructions have been used for joint-sparing resections, but little is known about the long-term outcome of these procedures. The authors reviewed a consecutive series of 64 patients treated with joint-sparing intercalary resection and reconstruction with bone grafts...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791699/a-comparative-effectiveness-study-for-non-operative-treatment-methods-for-knee-osteoarthritis
#5
Frank R Kolisek, Charles Jaggard, Anton Khlopas, Assem A Sultan, Nipun Sodhi, Michael A Mont
A number of non-operative treatment options are commonly prescribed for patients presenting with degenerative osteoarthritis of the knee, where surgery is not yet recommended. However, there is a paucity of studies evaluating the comparative effectiveness of these treatment options to best inform both patients and providers. This study examined the comparative effectiveness of a home exercise program versus bracing or a combination of the two (brace-only, exercise-only, and brace and exercise cohorts) on the following: 1) objective functional measures (quadriceps muscle strength, Self-Paced Walk Test [SPWT], and Timed "Up & Go" [TUG] Test); 2) subjective functional measures (Lower Extremity Function Scale [LEFS] and Health Survey [VR-12] outcomes); 3) pain using Visual Analog Scale [VAS-10]; 4) patient metrics (patient treatment preference, perceptions, and compliance); and 5) progression to total knee arthroplasty (TKA) over a 12-week period...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791655/accuracy-of-sentinel-lymph-node-mapping-in-detecting-occult-neck-metastasis-in-papillary-thyroid-carcinoma
#6
Jose Higino Steck, Elaine Stabenow, Gustavo Baldove Bettoni, Samuel Steck, Claudio Roberto Cernea
OBJECTIVES: The objectives of this study were to evaluate the following: 1) the accuracy of sentinel lymph node mapping (SLNM) in detecting metastasis in papillary thyroid carcinoma (PTC), and 2) if SLNM could modify the American Joint Committee on Cancer (AJCC) staging of previous cN0 PTC patients. SUBJECTS AND METHODS: Forty SLNM were performed prospectively in 38 consecutive cN0 PTC patients, with total thyroidectomy and elective compartment neck dissection (CND)...
May 17, 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29790865/effect-of-joint-camp-on-patient-outcomes-following-total-joint-replacement
#7
Ivana Dehorney, Pamela F Ashcraft
Two major cost concerns related to joint replacement surgery are patient length of stay (LOS) and 30-day hospital readmission rates. A quality improvement project was implemented to evaluate the impact of a joint replacement program on patient readmissions and hospital LOS. A total of 1425 patients older than 50 years participated. At the end of the project period, readmission rates decreased from 6.19% to 2.8% and average LOS decreased from 5.87 days to 2.7 days.
July 2018: Journal of Nursing Care Quality
https://www.readbyqxmd.com/read/29790792/dorsal-plating-for-intra-articular-middle-phalangeal-base-fractures-with-volar-instability
#8
Travis A Doering, Andrew S Greenberg, David V Tuckman
BACKGROUND: Intra-articular middle phalangeal base fractures with volar instability are rare injuries with scant literature on optimal management. Our purpose is to describe our method of dorsal plating and report postoperative outcomes. METHODS: This study is a retrospective case review of 5 patients with intra-articular middle phalangeal base fractures with volar proximal interphalangeal joint instability, measuring subjective, clinical, and radiographic outcomes...
May 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29790635/the-effect-of-12-week-garlic-supplementation-on-symptom-relief-in-overweight-or-obese-women-with-knee-osteoarthritis
#9
Ahmad Salimzadeh, Elham Alipoor, Sahar Dehghani, Mehdi Yaseri, Mostafa Hosseini, Christine Feinle-Bisset, Mohammad Javad Hosseinzadeh-Attar
AIMS: Chronic joint pain and stiffness, and functional disability, are the major debilitating features of osteoarthritis (OA). The aim of this study was to assess the effect of 12-week supplementation with a garlic supplement on knee osteoarthritis outcomes in overweight or obese women. METHODS: Seventy-six postmenopausal overweight or obese women (25≤BMI≤40 kg/m2 ) with medically diagnosed knee OA participated in this randomised double-blind, placebo-controlled, parallel-design trial...
May 23, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29790120/changes-in-the-augmentation-index-and-postoperative-orthostatic-intolerance-in-orthopedic-surgery-a-prospective-cohort-study
#10
Stavros G Memtsoudis, Eva E Mörwald, Kara Fields, Crispiana Cozowicz, Nigel E Sharrock, Mathias Opperer, Ottokar Stundner, Angie Zhang, George Go, Thomas Danninger
BACKGROUND: Postoperative orthostatic intolerance (OI) can be a major obstacle to early ambulation and its determinants are poorly understood. We aimed to study postoperative changes in vascular tone and their potential association with OI in various orthopedic surgical settings. METHODS: In this prospective cohort study, 350 patients undergoing total joint arthroplasty under neuraxial anesthesia or spine surgery under general anesthesia were enrolled. We determined the augmentation index (AI) as a measure of vascular tone and studied symptoms of OI using a validated questionnaire at various postoperative time points...
May 22, 2018: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29789212/fibrates-in-primary-prevention-of-cardiovascular-disease-comments-on-the-results-of-a-systematic-review-of-the-cochrane-collaboration
#11
Angel Brea, Jesús Millán, Juan F Ascaso, Mariano Blasco, Angel Díaz, Antonio Hernández-Mijares, Teresa Mantilla, Juan C Pedro-Botet, Xavier Pintó
Fibrates are drugs that reduce triglycerides, elevate high-density lipoproteins, as well as decrease small, dense LDL particles. The results of a study have recently been published by the Cochrane Collaboration on fibrates efficacy and safety in the primary prevention of cardiovascular disease. This study includes a systematic review and a meta-analysis of 6 studies (16,135 patients) that evaluated the clinical benefits of fibrates compared to placebo use or other lipid-lowering drugs. This review showed evidence of a protective effect of the fibrates compared with placebo as regards a reduction 16% of a compound objective of death due to cardiovascular disease, non-fatal myocardial infarction, or non-fatal cerebrovascular accident (NNT: 112), and that reduce coronary morbidity and mortality by 21% (NNT: 125)...
May 19, 2018: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/29788969/psychosocial-predictors-for-outcome-after-total-joint-arthroplasty-a-prospective-comparison-of-hip-and-knee-arthroplasty
#12
Marion Lindner, Olaf Nosseir, Anett Keller-Pliessnig, Per Teigelack, Martin Teufel, Sefik Tagay
BACKGROUND: As findings regarding predictors for good outcome after total joint arthroplasty are highly inconsistent, aim of this study was to investigate the influence of the psychosocial variables sense of coherence and social support as well as mental distress on physical outcome after surgery. It should be investigated if different predictors are important in patients after total hip arthroplasty (THA) compared to patients after total knee arthroplasty (TKA). METHODS: In a prospective design, 44 patients undergoing THA and 61 patients undergoing TKA were examined presurgery and 6 and 12 weeks after surgery using WOMAC (disease-specific outcome), SF-36 (health-related quality of life), BSI (psychological distress), SOC-13 (sense of coherence), and F-SozU (social support)...
May 22, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29788942/use-of-autologous-bone-marrow-stem-cell-implantation-for-osteonecrosis-of-the-knee-in-sickle-cell-disease-a-preliminary-report
#13
Gildasio Daltro, Bruno Adelmo Franco, Thiago Batista Faleiro, Davi Araujo Veiga Rosário, Paula Braga Daltro, Roberto Meyer, Vitor Fortuna
BACKGROUND: The purpose of our study was to evaluate safety, feasibility and clinical results of bone marrow mononuclear cell (BMC) implantation for early-stage osteonecrosis of the knee (OK) secondary to sickle cell disease. METHODS: Thirty-three SCD patients (45 knees) with OK treated with BMC implantation in the osteonecrotic lesion were clinically and functionally evaluated through the American Knee Society Clinical Score (KSS), Knee Functional Score (KFS) and Numeric Rating Scale (NRS) pain score...
May 22, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29788680/two-sequential-free-flaps-for-coverage-of-a-total-knee-implant
#14
Siew Weng Ng, Hui Chai Fong, Bien-Keem Tan
Knee revision arthroplasty following peri-prosthetic joint infections is a formidable challenge. Patients are at a high risk of recurrent infection, and the soft tissue over the revised implant is often of questionable quality. Flap reconstruction has improved the salvage rates of infected arthroplasties, and should be considered in all cases of revision arthroplasty. We present a challenging case requiring staged reconstruction with two free latissimus dorsi flaps after the initial use of a medial gastrocnemius flap...
May 2018: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/29788491/lowering-the-recurrence-rate-in-pigmented-villonodular-synovitis-a-series-of-120-resections
#15
Carl Ferdinand Capellen, Reinhold Tiling, Alexander Klein, Andrea Baur-Melnyk, Thomas Knösel, Christof Birkenmaier, Falk Roeder, Volkmar Jansson, Hans Roland Dürr
Objectives: Tenosynovial giant-cell tumour or pigmented villonodular synovitis is an aggressive synovial proliferative disease, with the knee joint being the most commonly affected joint. The mainstay of therapy is surgical resection. The aim of this study was to evaluate the main patient characteristics, treatment and outcomes in a large single-centre retrospective study, focusing on meticulous aggressive open surgical procedures. Methods: From 1996 through 2014, 122 surgical interventions were performed in 105 patients...
May 16, 2018: Rheumatology
https://www.readbyqxmd.com/read/29788392/prognostic-accuracy-of-different-lymph-node-staging-systems-in-rectal-adenocarcinoma-with-or-without-preoperative-radiation-therapy
#16
Feng Shen, Junhui Cui, Ke Cai, Haiqiang Pan, Heqi Bu, Feng Yu
Background and objective: A variety of different lymph node (LN) staging systems have been developed to describe the lymph node status accurately. We aim to compare the prognostic accuracy of American Joint Committee on Cancer seventh N stage relative to negative number of lymph node (nLN), lymph node ratio (LNR) and log odds of metastatic lymph nodes (LODDS) in rectal adenocarcinoma (RC). Methods: A total of 19 167 Stage II-III rectal cancer patients who underwent surgical resection of rectal adenocarcinoma were identified from Surveillance, Epidemiology and End Results database...
May 19, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29788111/acute-assessment-of-traumatic-brain-injury-and-post-traumatic-stress-after-exposure-to-a-deployment-related-explosive-blast
#17
Monty T Baker, John C Moring, Willie J Hale, Jim Mintz, Stacey Young-McCaughan, Richard A Bryant, Donna K Broshek, Jeffrey T Barth, Robert Villarreal, Cynthia L Lancaster, Steffany L Malach, Jose M Lara-Ruiz, William Isler, Alan L Peterson
Introduction: Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are two of the signature injuries in military service members who have been exposed to explosive blasts during deployments to Iraq and Afghanistan. Acute stress disorder (ASD), which occurs within 2-30 d after trauma exposure, is a more immediate psychological reaction predictive of the later development of PTSD. Most previous studies have evaluated service members after their return from deployment, which is often months or years after the initial blast exposure...
May 18, 2018: Military Medicine
https://www.readbyqxmd.com/read/29787593/improving-the-effectiveness-of-performance-feedback-by-considering-personality-traits-and-task-demands
#18
Victor Swift, Jordan B Peterson
Although performance feedback is widely employed as a means to improve motivation, the efficacy and reliability of performance feedback is often obscured by individual differences and situational variables. The joint role of these moderating variables remains unknown. Accordingly, we investigate how the motivational impact of feedback is moderated by personality and task-difficulty. Utilizing three samples (total N = 916), we explore how Big Five personality traits moderate the motivational impact of false positive and negative feedback on playful, neutral, and frustrating puzzle tasks, respectively...
2018: PloS One
https://www.readbyqxmd.com/read/29785926/intramedullary-nail-fixation-versus-locking-plate-fixation-for-adults-with-a-fracture-of-the-distal-tibia-the-uk-fixdt-rct
#19
Matthew L Costa, Juul Achten, Susie Hennings, Nafisa Boota, James Griffin, Stavros Petrou, Mandy Maredza, Melina Dritsaki, Thomas Wood, James Masters, Ian Pallister, Sarah E Lamb, Nick R Parsons
BACKGROUND: The best treatment for fractures of the distal tibia remains controversial. Most of these fractures require surgical fixation, but the outcomes are unpredictable and complications are common. OBJECTIVES: To assess disability, quality of life, complications and resource use in patients treated with intramedullary (IM) nail fixation versus locking plate fixation in the 12 months following a fracture of the distal tibia. DESIGN: This was a multicentre randomised trial...
May 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29785637/frzb1-rs2242070-polymorphisms-is-associated-with-brick-tea-type-skeletal-fluorosis-in-kazakhs-but-not-in-tibetans-china
#20
Yanmei Yang, Qiaoshi Zhao, Yang Liu, Xiaona Liu, Yanru Chu, Huazhu Yan, Yumei Fan, Simeng Huo, Limei Wang, Qun Lou, Ning Guo, Dianjun Sun, Yanhui Gao
Skeletal fluorosis is a metabolic bone and joint disease caused by excessive accumulation of fluoride in the bones. Compared with Kazakhs, Tibetans are more likely to develop moderate and severe brick tea type skeletal fluorosis, although they have similar fluoride exposure. Single nucleotide polymorphisms (SNPs) in frizzled-related protein (FRZB) have been associated with osteoarthritis, but their association with the risk of skeletal fluorosis has not been reported. In this paper, we investigated the association of three SNPs (rs7775, rs2242070 and rs9288087) in FRZB1with brick tea type skeletal fluorosis risk in a cross-sectional case-control study conducted in Sinkiang and Qinghai, China...
May 21, 2018: Archives of Toxicology
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