keyword
https://read.qxmd.com/read/38542788/role-of-dietary-factors-on-dna-methylation-levels-of-tnf-alpha-gene-and-proteome-profiles-in-obese-men
#21
JOURNAL ARTICLE
Chayanisa Boonrong, Sittiruk Roytrakul, Prapimporn Chattranukulchai Shantavasinkul, Piyamitr Sritara, Jintana Sirivarasai
UNLABELLED: Integrated omics-based platforms from epigenomics and proteomics technologies are used to identify several important mechanisms in obesity etiology, food components, dietary intake, regulation of biological pathways, and potential new intervention targets. Therefore, this study aimed to analyze whether dietary factors involved in the methylation of tumor necrosis factor (TNF)-α are implicated in differential protein expression in people with normal weight and obesity...
March 18, 2024: Nutrients
https://read.qxmd.com/read/38542785/higher-level-steatosis-is-associated-with-a-greater-decrease-in-metabolic-dysfunction-associated-steatoic-liver-disease-after-eight-weeks-of-a-very-low-calorie-ketogenic-diet-vlckd-in-subjects-affected-by-overweight-and-obesity
#22
JOURNAL ARTICLE
Annamaria Sila, Sara De Nucci, Caterina Bonfiglio, Vincenza Di Stasi, Nicole Cerabino, Martina Di Chito, Roberta Rinaldi, Paola Cantalice, Endrit Shahini, Vito Giannuzzi, Pasqua Letizia Pesole, Sergio Coletta, Nicoletta Maria Tutino, Giuseppina Piazzolla, Raffaele Cozzolongo, Gianluigi Giannelli, Giovanni De Pergola
The most common form of chronic liver disease, recently defined as MASLD, is strongly linked to obesity and metabolic syndrome. Lifestyle changes are part of MASLD prevention. The very low-calorie ketogenic diet (VLCKD) is a useful option for treating MASLD and reducing liver steatosis in patients with obesity. We assessed whether a greater degree of steatosis could have a positive or negative impact on how well 8 weeks of using the VLCKD improve steatosis and fibrosis in a patient population of overweight and obese individuals...
March 18, 2024: Nutrients
https://read.qxmd.com/read/38542783/glycomacropeptide-as-an-efficient-agent-to-fight-pathophysiological-mechanisms-of-metabolic-syndrome
#23
JOURNAL ARTICLE
Mathilde Foisy Sauvé, Francis Feldman, Alain Théophile Sané, Mireille Koudoufio, Natalie Patey, Schohraya Spahis, James Butcher, Haonan Duan, Daniel Figeys, Valérie Marcil, Alain Stintzi, Emile Levy
There is currently a growing interest in the use of nutraceuticals as a means of preventing the development of complex diseases. Given the considerable health potential of milk-derived peptides, the aim of this study was to investigate the protective effects of glycomacropeptide (GMP) on metabolic syndrome. Particular emphasis was placed on the potential mechanisms mitigating cardiometabolic disorders in high-fat, high-fructose diet-fed mice in the presence of GMP or Bipro, an isocaloric control. The administration of GMP for 12 weeks reduced obesity, hyperglycemia and hyperinsulinemia caused by a high-fat, high-fructose diet, resulting in a decline in insulin resistance...
March 17, 2024: Nutrients
https://read.qxmd.com/read/38542777/exploring-the-role-of-serum-osteonectin-and-hsp27-in-pediatric-mafld-diagnosis-and-cardiometabolic-health
#24
JOURNAL ARTICLE
Anca Bălănescu, Paul-Cristian Bălănescu, Ioana Florentina Codreanu, Iustina-Violeta Stan, Valentina-Daniela Comanici, Alina Maria Robu, Tatiana Ciomârtan
BACKGROUND: Childhood obesity is one of the major challenges of public health policies. The problem of fatty liver in childhood, known as MAFLD (metabolic dysfunction-associated fatty liver disease), is of particular interest as the gold standard diagnosis technique is invasive (liver biopsy). Hence, efforts are made to discover more specific biomarkers for the MAFLD signature. Therefore, the aim of the study was to evaluate Osteonectin and Hsp27 as biomarkers for MAFLD diagnosis and to assess their links with auxological and biochemical profiles of overweight and obese pediatric subjects...
March 16, 2024: Nutrients
https://read.qxmd.com/read/38542768/the-effects-of-olive-oil-consumption-on-biochemical-parameters-and-body-mass-index-of-people-with-nonalcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#25
REVIEW
Georgios Tsamos, Georgios Kalopitas, Kleo Evripidou, Dimitra Vasdeki, Theocharis Koufakis, Vasileios Kanavas, Christina Antza, Georgios Germanidis, Michail Chourdakis
Nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disorder, is closely associated with insulin resistance, obesity, and metabolic syndromes. A body of research has proposed that olive oil, a basic component of the Mediterranean diet with antioxidant and anti-inflammatory properties, may alleviate metabolic disturbances and retard the progression of NAFLD. We conducted a systematic review and meta-analysis to assess the effectiveness of olive oil intake in people with NAFLD. We systematically searched the major electronic databases (PubMed/MEDLINE, Scopus, Cochrane Central Register of Controlled Trials), as well as grey literature sources, to identify randomized controlled trials (RCTs) investigating the effects of olive oil consumption on biochemical and anthropometric parameters of individuals with NAFLD...
March 15, 2024: Nutrients
https://read.qxmd.com/read/38542756/the-mechanism-of-the-anti-obesity-effects-of-a-standardized-brassica-juncea-extract-in-3t3-l1-preadipocytes-and-high-fat-diet-induced-obese-c57bl-6j-mice
#26
JOURNAL ARTICLE
June-Seok Lim, Ji-Hyun Im, Xionggao Han, Xiao Men, Geon Oh, Xiaolu Fu, Woonsang Hwang, Sun-Il Choi, Ok-Hwan Lee
Obesity is a global health concern. Recent research has suggested that the development of anti-obesity ingredients and functional foods should focus on natural products without side effects. We examined the effectiveness and underlying mechanisms of Brassica juncea extract (BJE) in combating obesity via experiments conducted in both in vitro and in vivo obesity models. In in vitro experiments conducted in a controlled environment, the application of BJE demonstrated the ability to suppress the accumulation of lipids induced by MDI in 3T3-L1 adipocytes...
March 15, 2024: Nutrients
https://read.qxmd.com/read/38542722/mental-health-and-body-image-and-the-reduction-of-excess-body-weight-in-woman-polish-sample
#27
JOURNAL ARTICLE
Hanna Liberska, Klaudia Boniecka
In recent years, excessive body weight has become one of the most serious psychological, biological and social problems. According to forecasts by the World Health Organization, obesity and overweight will continue to increase among both adults and children in the coming years. Poland ranks sixth in Europe in this respect. In 2021, almost 58% of Poles had above-average body weight (overweight or obesity). In Poland, 29% of women are overweight, and 21% of women are obese. Body dissatisfaction, depression, and anxiety disorder are indicated as consequences of high BMI in women...
March 13, 2024: Nutrients
https://read.qxmd.com/read/38542714/a-cross-sectional-quantitative-metabolomics-study-evidencing-the-metabolic-signature-in-six-organs-during-a-14-week-high-fat-high-sucrose-and-standard-diet-in-mice
#28
JOURNAL ARTICLE
Eva Drevet Mulard, Sylvie Guibert, Anne Mey, Camille Lefevre, Marie-Agnès Chauvin, Claudie Pinteur, Marie-Ambre Monet, Murielle Godet, Anne-Marie Madec, Béatrice Morio, Jennifer Rieusset, Gilles J P Rautureau, Baptiste Panthu
Obesity is a risk factor for many diseases, such as type 2 diabetes and cardiovascular diseases. In line with the need for precision medicine, the search for biomarkers reporting the progression of obesity- and diet-associated disorders is urgent. We used NMR to determine the metabolomics profile of key organs (lung, liver, heart, skeletal muscle, kidney, and brain) and serum from male C57Bl/6J mice (5 weeks old) fed for 6, 10, and 14 weeks on a high-fat and high-sucrose diet (HFHSD) vs. a standard diet (STD)...
March 12, 2024: Nutrients
https://read.qxmd.com/read/38542534/tocotrienols-prevent-the-decline-of-learning-ability-in-high-fat-high-sucrose-diet-fed-c57bl-6-mice
#29
JOURNAL ARTICLE
Yugo Kato, Junhyoku Ben, Atsuto Noto, Shuntaro Kashiwaya, Yoshinori Aoki, Nobuo Watanabe, Hiroki Tsumoto, Yuri Miura, Koji Fukui
Obesity has been increasing worldwide and is well-known as a risk factor for cognitive decline. It has been reported that oxidative stress in the brain is deeply involved in cognitive dysfunction in rodent models. While there are many studies on oxidation in the liver and adipose tissue of obese mice, the relationship between obesity-induced cognitive dysfunction and brain oxidation has not been elucidated. Here, we show that obesity induced by a high-fat, high-sucrose diet (HFSD) alters cognitive function in C57BL/6 male mice, and it may involve the acceleration of brain oxidation...
March 21, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542451/the-brain-metabolome-is-modified-by-obesity-in-a-sex-dependent-manner
#30
JOURNAL ARTICLE
Jennifer E Norman, Dragan Milenkovic, Saivageethi Nuthikattu, Amparo C Villablanca
Obesity is linked to cognitive decline and metabolic dysregulation in the brain, yet the role of sex is relatively unexplored. We sought to explore the effects of obesity and sex on the brain metabolome. In male and female ob/ob and wild-type mice, we assessed whole brain untargeted metabolomics by liquid chromatography-mass spectrometry, behavior by open field test, and cognitive function by Y-maze and Morris water maze. The metabolic profiles of ob/ob and wild-type mice differed in both sexes. There were more obesity-altered brain metabolites in males than females...
March 20, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542392/autumn-olive-elaeagnus-umbellata-thunb-berries-improve-lipid-metabolism-and-delay-aging-in-middle-aged-caenorhabditis-elegans
#31
JOURNAL ARTICLE
Yebin Kim, Seonghyeon Nam, Jongbin Lim, Miran Jang
This study evaluated the positive effects of autumn olive berries (AOBs) extract on delaying aging by improving lipid metabolism in middle-aged Caenorhabditis elegans that had become obese due to a high-glucose (GLU) diet. The total phenolic content and DPPH radical scavenging abilities of freeze-dried AOBs (FAOBs) or spray-dried AOBs (SAOBs) were examined, and FAOBs exhibited better antioxidant activity. HPLC analysis confirmed that catechin is the main phenolic compound of AOBs; its content was 5.95 times higher in FAOBs than in SAOBs...
March 18, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542390/standard-doses-of-cholecalciferol-reduce-glucose-and-increase-glutamine-in-obesity-related-hypertension-results-of-a-randomized-trial
#32
JOURNAL ARTICLE
Catarina Santos, Rui Carvalho, Ana Mafalda Fonseca, Miguel Castelo Branco, Marco Alves, Ivana Jarak
In arterial hypertension, the dysregulation of several metabolic pathways is closely associated with chronic immune imbalance and inflammation progression. With time, these disturbances lead to the development of progressive disease and end-organ involvement. However, the influence of cholecalciferol on metabolic pathways as a possible mechanism of its immunomodulatory activity in obesity-related hypertension is not known. In a phase 2, randomized, single-center, 24-week trial, we evaluated, as a secondary outcome, the serum metabolome of 36 age- and gender-matched adults with obesity-related hypertension and vitamin D deficiency, before and after supplementation with cholecalciferol therapy along with routine medication...
March 18, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542331/gene-and-lncrna-profiling-of-%C3%AF-3-%C3%AF-6-polyunsaturated-fatty-acid-exposed-human-visceral-adipocytes-uncovers-different-responses-in-healthy-lean-obese-and-colorectal-cancer-affected-individuals
#33
JOURNAL ARTICLE
Sabrina Tait, Enrica Calura, Antonella Baldassarre, Andrea Masotti, Barbara Varano, Sandra Gessani, Lucia Conti, Manuela Del Cornò
Colorectal cancer (CRC) is a major life-threatening disease, being the third most common cancer and a leading cause of death worldwide. Enhanced adiposity, particularly visceral fat, is a major risk factor for CRC, and obesity-associated alterations in metabolic, inflammatory and immune profiles in visceral adipose tissue (VAT) strongly contribute to promoting or sustaining intestinal carcinogenesis. The role of diet and nutrition in obesity and CRC has been extensively demonstrated, and AT represents the main place where diet-induced signals are integrated...
March 15, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542273/the-renin-angiotensin-system-and-cardiovascular-kidney-metabolic-syndrome-focus-on-early-life-programming
#34
REVIEW
You-Lin Tain, Chien-Ning Hsu
The identification of pathological links among metabolic disorders, kidney ailments, and cardiovascular conditions has given rise to the concept of cardiovascular-kidney-metabolic (CKM) syndrome. Emerging prenatal risk factors seem to increase the likelihood of CKM syndrome across an individual's lifespan. The renin-angiotensin system (RAS) plays a crucial role in maternal-fetal health and maintaining homeostasis in cardiovascular, metabolic, and kidney functions. This review consolidates current preclinical evidence detailing how dysregulation of the RAS during pregnancy and lactation leads to CKM characteristics in offspring, elucidating the underlying mechanisms...
March 14, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542220/the-role-of-neutral-sphingomyelinase-2-nsm2-in-the-control-of-neutral-lipid-storage-in-t-cells
#35
JOURNAL ARTICLE
Rebekka Schempp, Janna Eilts, Marie Schöl, Maria Fernanda Grijalva Yépez, Agnes Fekete, Dominik Wigger, Fabian Schumacher, Burkhard Kleuser, Marco van Ham, Lothar Jänsch, Markus Sauer, Elita Avota
The accumulation of lipid droplets (LDs) and ceramides (Cer) is linked to non-alcoholic fatty liver disease (NAFLD), regularly co-existing with type 2 diabetes and decreased immune function. Chronic inflammation and increased disease severity in viral infections are the hallmarks of the obesity-related immunopathology. The upregulation of neutral sphingomyelinase-2 (NSM2) has shown to be associated with the pathology of obesity in tissues. Nevertheless, the role of sphingolipids and specifically of NSM2 in the regulation of immune cell response to a fatty acid (FA) rich environment is poorly studied...
March 13, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542217/metabolic-crossroads-unveiling-the-complex-interactions-between-obstructive-sleep-apnoea-and-metabolic-syndrome
#36
REVIEW
Aisling Heffernan, Darko Duplancic, Marko Kumric, Tina Ticinovic Kurir, Josko Bozic
Obstructive sleep apnoea (OSA) and components of metabolic syndrome (MetS) are inextricably connected. Considering the increasing burden of MetS and OSA, in the present review, we aimed to collate and summarise the potential pathophysiological mechanisms linking these pathologies. In short, obesity appears to promote OSA development via multiple pathways, some of which are not directly related to mass but rather to metabolic complications of obesity. Simultaneously, OSA promotes weight gain through central mechanisms...
March 13, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542170/mitochondria-associated-membranes-as-key-regulators-in-cellular-homeostasis-and-the-potential-impact-of-exercise-on-insulin-resistance
#37
REVIEW
Xi Li, Yangjun Yang, Xiaoyu Shi, Zhe Zhang, Shuzhe Ding
The communication between mitochondria and the endoplasmic reticulum (ER) is facilitated by a dynamic membrane structure formed by protein complexes known as mitochondria-associated membranes (MAMs). The structural and functional integrity of MAMs is crucial for insulin signal transduction, relying heavily on their regulation of intracellular calcium homeostasis, lipid homeostasis, mitochondrial quality control, and endoplasmic reticulum stress (ERS). This article reviews recent research findings, suggesting that exercise may promote the remodeling of MAMs structure and function by modulating the expression of molecules associated with their structure and function...
March 11, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542065/regeneration-of-non-alcoholic-fatty-liver-cells-using-chimeric-fgf21-hgfr-a-novel-therapeutic-approach
#38
JOURNAL ARTICLE
Sung-Jun Kim, So-Jung Kim, Jeongeun Hyun, Hae-Won Kim, Jun-Hyeog Jang
Non-alcoholic fatty liver disease (NAFLD) has emerged as a significant liver ailment attributed to factors like obesity and diabetes. While ongoing research explores treatments for NAFLD, further investigation is imperative to address this escalating health concern. NAFLD manifests as hepatic steatosis, precipitating insulin resistance and metabolic syndrome. This study aims to validate the regenerative potential of chimeric fibroblast growth factor 21 (FGF21) and Hepatocyte Growth Factor Receptor (HGFR) in NAFLD-afflicted liver cells...
March 7, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541985/barriers-to-adolescents-adherence-to-medical-advice-after-metabolic-bariatric-surgery-a-statistical-analysis
#39
JOURNAL ARTICLE
Evia Shellac, Rachel Lev-Wiesel, Iris Shachar-Lavie, Arie Hadas, Adi Sela, Irit Halifa-Kurzman, Adi Bar-Eyal, Shlomit Shalitin, Dragan Kravarusic, Osher Cohen, Simona Tyroler, Orly Lavan, Silvana Fennig
Background: Adolescent obesity has markedly increased worldwide, and metabolic bariatric surgery is an effective treatment option. A major predictor of the outcomes of this procedure is adherence to post-surgery lifestyle changes and medical recommendations. While adolescents generally have more difficulty adhering to medical advice than adults, their failure to do so could adversely affect their physical and psychological health, the cost-effectiveness of medical care, and the results of clinical trials. To our knowledge, this is the first attempt to identify the characteristics associated with the adherence of adolescents and their families to medical advice after bariatric surgery...
March 19, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541884/obesity-related-hemodynamic-alterations-in-patients-with-cushing-s-disease
#40
JOURNAL ARTICLE
Agnieszka Jurek, Paweł Krzesiński, Beata Uziębło-Życzkowska, Przemysław Witek, Grzegorz Zieliński, Robert Wierzbowski, Anna Kazimierczak, Małgorzata Banak, Grzegorz Gielerak
Background : Cushing's disease (CD) is associated with a specific form of metabolic syndrome that includes visceral obesity, which may affect cardiovascular hemodynamics by stimulating hypercortisolism-related metabolic activity. The purpose of this study was to evaluate the relationship between obesity and the hemodynamic profile of patients with CD. Methods : This prospective clinical study involved a hemodynamic status assessment of 54 patients newly diagnosed with CD with no significant comorbidities (mean age of 41 years)...
March 14, 2024: Journal of Clinical Medicine
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