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Metabolic obesity

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https://www.readbyqxmd.com/read/28531773/impact-of-metabolic-syndrome-on-resting-energy-expenditure-in-patients-with-chronic-kidney-disease
#1
Carolina Q D Rodrigues, Jacqueline A P Santos, Beata M R Quinto, Mauro S M Marrocos, Andrei A Teixeira, Cássio J O Rodrigues, Marcelo C Batista
BACKGROUND & AIMS: Resting energy expenditure (REE) changes in patients with chronic kidney disease (CKD) may contribute to mortality increase. The obesity and inflammation is associated with high REE and when not compensated by adequate intake, may determine an unfavorable clinical outcome in this population. We aimed to evaluate the influence of metabolic syndrome (MetS) on REE in CKD patients. METHODS: One hundred eighty-three patients were stratified according to glomerular filtration rate (GFR) and divided in groups: without CKD (GFR > 60 ml/min/1...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531393/the-rs10401670-variant-in-resistin-gene-improved-insulin-resistance-response-and-metabolic-parameters-secondaries-to-weight-loss-after-a-hypocaloric-diet
#2
Daniel Antonio de Luis, Rocío Aller, Olatz Izaola, David Primo, R Bachiller
BACKGROUND: The SNP 3'UTR C/T (rs10401670), it is a polymorphism that has been associated with diabetes mellitus and it has been scarcely studied before. As far as we know, no studies on interaction among diet intervention, rs10401670 variant of RETN and metabolic response has been realized. OBJECTIVE: Our aim was to analyze the effects of the rs10401670 RETN gene polymorphism on insulin resistance response and metabolic changes secondary to weight loss after 3 months of a hypocaloric diet in adults obese patients without diabetes mellitus...
August 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531131/the-role-of-interleukin-18-oxidative-stress-and-metabolic-syndrome-in-alzheimer-s-disease
#3
REVIEW
Johanna O Ojala, Elina M Sutinen
The role of interleukins (ILs) and oxidative stress (OS) in precipitating neurodegenerative diseases including sporadic Alzheimer's disease (AD), requires further clarification. In addition to neuropathological hallmarks-extracellular neuritic amyloid-β (Aβ) plaques, neurofibrillary tangles (NFT) containing hyperphosphorylated tau and neuronal loss-chronic inflammation, as well as oxidative and excitotoxic damage, are present in the AD brain. The pathological sequelae and the interaction of these events during the course of AD need further investigation...
May 21, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28531113/retrospective-evaluation-of-metformin-and-or-metformin-plus-a-new-polysaccharide-complex-in-treating-severe-hyperinsulinism-and-insulin-resistance-in-obese-children-and-adolescents-with-metabolic-syndrome
#4
Stefano Stagi, Franco Ricci, Martina Bianconi, Maria Amina Sammarco, Giovanna Municchi, Sonia Toni, Lorenzo Lenzi, Alberto Verrotti, Maurizio de Martino
Background: Pharmacological treatment of obesity and glucose-insulin metabolism disorders in children may be more difficult than in adults. Thus, we evaluate the effects of metformin in comparison with metformin plus a polysaccharide complex (Policaptil Gel Retard(®), PGR) on body weight and metabolic parameters in obese children and adolescents with metabolic syndrome (MetS). Patients and methods: We retrospectively collected 129 children and adolescents (67 girls, 62 boys; median age 12.6 years) treated for a minimum of two years with metformin and low glycemic index (LGI) diet...
May 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28530168/microbe-profile-akkermansia-muciniphila-a-conserved-intestinal-symbiont-that-acts-as-the-gatekeeper-of-our-mucosa
#5
Willem M de Vos
Akkermansia muciniphila is an abundant inhabitant of the intestinal tract of humans and many other animals. It is the sole intestinal representative of the verrucomicrobia in human stools and depleted in adults suffering from obesity, diabetes and several other diseases. A. muciniphila degrades intestinal mucin into mainly propionic and acetic acid, and lives in symbiosis with its host, marked by signalling to immune and metabolic pathways, priming trophic chains and likely providing competitive exclusion at the host-microbe interface...
May 22, 2017: Microbiology
https://www.readbyqxmd.com/read/28529941/humans-and-mice-display-opposing-patterns-of-browning-gene-expression-in-visceral-and-subcutaneous-white-adipose-tissue-depots
#6
Maria A Zuriaga, Jose J Fuster, Noyan Gokce, Kenneth Walsh
Visceral adiposity is much more strongly associated with cardiometabolic disease in humans than subcutaneous adiposity. Browning, the appearance of brown-like adipocytes in the white adipose tissue (WAT), has been shown to protect mice against metabolic dysfunction, suggesting the possibility of new therapeutic approaches to treat obesity and type 2 diabetes. In mice, subcutaneous WAT depots express higher levels of browning genes when compared with visceral WAT, further suggesting that differences in WAT browning could contribute to the differences in the pathogenicity of the two depots...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28529818/high-protein-fish-oil-diet-prevents-hepatic-steatosis-in-noncnzo10-mice-association-with-diet-genetics-regulated-micro-rnas
#7
Nikhil Adi, Jennipher Adi, Roberta Marques Lassance-Soares, Paul Kurlansky, Hong Yu, Keith A Webster
OBJECTIVE: NONcNZO10 (NZ10) mice are predisposed to obesity and develop type 2 diabetes (T2D) and hepatic steatosis even when maintained on a control diet (CD) of 6% fat. Studies were designed to determine whether this extreme susceptibility phenotype could be alleviated by diet and if so the molecular targets of diet. METHODS: NZ10 and SWR/J (SWR) control mice were fed a CD or a test diet of high protein and fish oil (HPO) for 19 weeks and then analyzed for steatosis, blood chemistry, hepatic gene and micro-RNA expression...
June 2016: Journal of Diabetes & Metabolism
https://www.readbyqxmd.com/read/28529534/the-role-of-a-dairy-fraction-rich-in-milk-fat-globule-membrane-in-the-suppression-of-postprandial-inflammatory-markers-and-bone-turnover-in-obese-and-overweight-adults-an-exploratory-study
#8
Tara S Rogers, Elieke Demmer, Nancy Rivera, Erik R Gertz, J Bruce German, Jennifer T Smilowitz, Angela M Zivkovic, Marta D Van Loan
BACKGROUND: Inflammation is associated with increased bone resorption; the role of inflammation in postprandial bone turnover has not been explored. Consumption of milk fat globule membrane (MFGM) reduces inflammation in animal models. This study aimed to measure postprandial changes in bone turnover after intake of high saturated fat test meals, with- and without the anti-inflammatory ingredient MFGM. METHODS: Subjects (n = 36 adults) were obese (BMI 30-39...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28529330/dietary-medium-chain-saturated-fatty-acids-induce-gene-expression-of-energy-metabolism-related-pathways-in-adipose-tissue-of-abdominally-obese-subjects
#9
J C Matualatupauw, M Bohl, S Gregersen, K Hermansen, L A Afman
BACKGROUND: Dietary medium-chain saturated fatty acids (MC-SFAs) have been shown to reduce total body fat. Previously, we showed that MC-SFAs prevent body fat accumulation, despite weight gain. Here, we aim to explore potential molecular mechanisms underlying the protective effect of MC-SFAs on body fat gain. METHODS: The DairyHealth study examined the long-term effects of milk protein and milk fat with a low or high content of MC-SFA. In this 12 week, randomized, double-blind, diet intervention study, participants consumed 60 g milk protein (whey or casein) and 63 g milk fat (high MC-SFA or low MC-SFA) daily in a 2 by 2 factorial design...
May 22, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28529329/body-mass-index-growth-trajectories-associated-with-the-different-parameters-of-the-metabolic-syndrome-at-adulthood
#10
K V Giudici, M-F Rolland-Cachera, G Gusto, D Goxe, O Lantieri, S Hercberg, S Péneau
BACKGROUND: Growth trajectories have shown to be related to obesity and metabolic risks in later life, however body mass index (BMI) trajectories according to the presence or absence of metabolic syndrome (MS) and its parameters in adulthood are scarce in literature. OBJECTIVES: To investigate BMI trajectories during childhood in relation to MS and its parameters in adult age. METHODS: A total of 1919 subjects (43.4% male, 20-60y) participated in this retrospective cohort study...
May 22, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28529327/metabolite-profiling-of-obese-individuals-before-and-after-a-one-year-weight-loss-program
#11
N Geidenstam, M Al-Majdoub, M Ekman, P Spégel, M Ridderstråle
OBJECTIVE: We and others have previously characterized changes in circulating metabolite levels following diet-induced weight loss. Our aim was to investigate if baseline metabolite levels and weight loss-induced changes in these are predictive of or associated with changes in body mass index (BMI) and metabolic risk traits. METHODS: Serum metabolites were analyzed with gas and liquid chromatography/mass spectrometry in 91 obese individuals at baseline and after participating in a one year non-surgical weight loss program...
May 22, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28529242/hyperuricemia-as-a-protective-factor-for-mild-cognitive-impairment-in-non-obese-elderly
#12
Feng Wang, Minghui Zhao, Zhaoli Han, Dai Li, Shishuang Zhang, Yongqiang Zhang, Xiaodong Kong, Ning Sun, Qiang Zhang, Ping Lei
Mild cognitive impairment (MCI) is regarded as incipient dementia. Patients with MCI have increased risk of later progressing to dementia. Blood uric acid (UA) is an important non-enzymatic antioxidant in peripheral circulation, and plays an unconfirmed protective role in MCI. Furthermore, obesity-induced inflammation, which affects UA metabolism and MCI onset, might regulate such protective role. Thus, the aim of the study was to determine the relationship of UA to MCI and the potential effect from inflammation...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28529179/mitochondria-and-endoplasmic-reticulum-targets-for-a-better-insulin-sensitivity-in-skeletal-muscle
#13
REVIEW
Alexis Boulinguiez, Bart Staels, Helene Duez, Steve Lancel
Obesity and its associated metabolic disorders represent a major health burden, with economic and social consequences. Although adapted lifestyle and bariatric surgery are effective in reducing body weight, obesity prevalence is still rising. Obese individuals often become insulin-resistant. Obesity impacts on insulin responsive organs, such as the liver, adipose tissue and skeletal muscle, and increases the risk of cardiovascular diseases, type 2 diabetes and cancer. In this review, we discuss the effects of obesity and insulin resistance on skeletal muscle, an important organ for the control of postprandial glucose...
May 18, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28529065/brown-adipose-tissue-and-lipid-metabolism-imaging
#14
REVIEW
Andreas Paulus, Wouter van Marken Lichtenbelt, Felix M Mottaghy, Matthias Bauwens
PURPOSE: Brown adipose tissue (BAT) research has evolved from an underestimated to a fast developing field. Its assumed curing properties for the world wide epidemic obesity, and its related diseases, makes this tissue an interesting target for a broad amount of non-invasive molecular BAT tracers. Apart from (18)F-FDG PET/CT there are several methods to detect BAT and measure its metabolism in a more appropriate way. Especially interesting is the measure of lipid turnover, because fatty acids comprise the main fuel for active BAT...
May 18, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28528703/does-fitness-improve-the-cardiovascular-risk-profile-in-obese-subjects
#15
H Halland, M T Lønnebakken, S Saeed, H Midtbø, D Cramariuc, E Gerdts
BACKGROUND AND AIMS: Good cardiorespiratory fitness has been suggested to reduce the risk of cardiovascular disease in obesity. We explored the association of fitness with the prevalences of major cardiovascular risk factor like hypertension (HT), diabetes and metabolic syndrome (MetS) in overweight and obese subjects. METHODS AND RESULTS: Clinical data from 491 participants in the FAT associated CardiOvasculaR dysfunction (FATCOR) study were analyzed. Physical fitness was assessed by ergospirometry, and subjects with at least good level of performance for age and sex were classified as fit...
April 26, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28528593/polymannuronic-acid-ameliorated-obesity-and-inflammation-associated-with-a-high-fat-and-high-sucrose-diet-by-modulating-the-gut-microbiome-in-a-murine-model
#16
Fang Liu, Xiong Wang, Hongjie Shi, Yuming Wang, Changhu Xue, Qing-Juan Tang
Polymannuronic acid (PM), one of numerous alginates isolated from brown seaweeds, is known to possess antioxidant activities. In this study, we examined its potential role in reducing body weight gain and attenuating inflammation induced by a high-fat and high-sucrose diet (HFD) as well as its effect on modulating the gut microbiome in mice. A 30-d PM treatment significantly reduced the diet-induced body weight gain and blood TAG levels (P2·0). PM also had a profound impact on the microbial composition in the gut microbiome and resulted in a distinct microbiome structure...
May 22, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28528338/chronic-glibenclamide-treatment-attenuates-walker-256-tumour-growth-in-prediabetic-obese-rats
#17
Claudinéia Conationi da Silva Franco, Carina Previate, Kátia Gama de Barros Machado, Silvano Piovan, Rosiane Aparecida Miranda, Kelly Valério Prates, Veridiana Mota Moreira, Júlio Cezar de Oliveira, Luiz Felipe Barella, Rodrigo Mello Gomes, Flávio Andrade Francisco, Isabela Peixoto Martins, Audrei Pavanello, Tatiane Aparecida Ribeiro, Laize Peron Tófolo, Ananda Malta, Aline Amenencia de Souza, Vander Silva Alves, Sandra da Silva Silveira, Maria Raquel Marçal Natali, Jean Carlos Fernando Besson, Hely de Morais, Helenir Medri de Souza, Juliane Rocha de Sant Anna, Marialba Avezum Alves de Castro Prado, Paulo Cezar de Freitas Mathias
BACKGROUND/AIMS: The sulphonylurea glibenclamide (Gli) is widely used in the treatment of type 2 diabetes. In addition to its antidiabetic effects, low incidences of certain types of cancer have been observed in Gli-treated diabetic patients. However, the mechanisms underlying this observation remain unclear. The aim of the present work was to evaluate whether obese adult rats that were chronically treated with an antidiabetic drug, glibenclamide, exhibit resistance to rodent breast carcinoma growth...
May 11, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28527691/food-and-water-intake-body-temperature-and-metabolic-consequences-of-interleukin-1%C3%AE-microinjection-into-the-cingulate-cortex-of-the-rat
#18
B Csetényi, E Hormay, I Szabó, G Takács, B Nagy, K László, Z Karádi
In order to elucidate whether cytokine mechanisms of the cingulate cortex (cctx) are important in the central regulation of homeostasis, in the present study, feeding-metabolic effects of direct bilateral microinjection of interleukin-1β (IL-1β) into the cctx of the rat have been investigated. Short- (2h), medium (12h) and long-term (24h) food and water intakes and body temperature were measured after the intracerebral administration of this primary cytokine or vehicle solution, with or without paracetamol pretreatment...
May 17, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28527530/intergenerational-impact-of-maternal-overnutrition-and-obesity-throughout-pregnancy-in-sheep-on-metabolic-syndrome-in-grandsons-and-granddaughters
#19
C L Pankey, M W Walton, J F Odhiambo, A M Smith, A B Ghnenis, P W Nathanielsz, S P Ford
We previously reported that maternal overnutrition and obesity (MO) throughout pregnancy and lactation in sheep (MOF0) decreases term fetal pancreatic β-cell numbers and increases perirenal adiposity producing hyperphagia, increased adiposity and insulin resistance in adult female offspring (MOF1) fed ad libitum. Pregnant female MOF1 exhibited increased blood glucose from mid to late gestation vs control F1 (CTRF1) though both groups ate only to NRC recommendations. MOF1 ewes delivered female offspring (F2) who like their MOF1 mothers exhibited increased abdominal adiposity and absent neonatal leptin surge...
April 22, 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/28527122/effects-of-cigarette-smoke-exposure-during-suckling-on-food-intake-fat-mass-hormones-and-biochemical-profile-of-young-and-adult-female-rats
#20
Patricia Cristina Lisboa, Patricia Novaes Soares, Thamara Cherem Peixoto, Janaine Cavalcanti Carvalho, Camila Calvino, Vanessa Silva Tavares Rodrigues, Dayse Nascimento Bernardino, Viviane Younes-Rapozo, Alex Christian Manhães, Elaine de Oliveira, Egberto Gaspar de Moura
PURPOSE: Children from smoking mothers have a higher risk of developing obesity and associated comorbidities later in life. Different experimental models have been used to assess the mechanisms involved with this increased risk. Using a rat model of neonatal nicotine exposure via implantation of osmotic minipumps in lactating dams, we have previously shown marked sexual dimorphisms regarding metabolic and endocrine outcomes in the adult progeny. Considering that more than four thousand substances are found in tobacco smoke besides nicotine, we then studied a rat model of neonatal tobacco smoke exposure: adult male offspring had hyperphagia, obesity, hyperglycemia, hypertriglyceridemia, secondary hyperthyroidism and lower adrenal hormones...
May 19, 2017: Endocrine
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