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Metabolic obesity

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https://www.readbyqxmd.com/read/28329522/multiple-miliary-osteoma-cutis-of-the-face-associated-with-albright-hereditary-osteodystrophy-in-the-setting-of-acne-vulgaris-a-case-report
#1
Joseph V Caravaglio, Rema Gupta, David Weinstein
Osteoma cutis is a condition characterized by theformation of bone within the skin. Such aberrantossification of the skin and subcutaneous tissue isconsidered primary when it arises in the absence ofunderlying tissue damage or a preceding cutaneouslesion. Conversely, secondary osteoma cutis occurswhen skin ossification is the result of a pre-existingskin lesion, trauma, or inflammatory process [1,2].Although rare, primary osteoma cutis has beenassociated with a number of different geneticdisorders. Albright hereditary osteodystrophy (AHO),a condition first described in 1942 by Fuller Albright,is an autosomal dominant metabolic disorder causedby a mutation in the GNAS1 gene [3]...
March 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329372/practical-review-of-recognition-and-management-of-obesity-and-lipohypertrophy-in-hiv-infection
#2
Jordan E Lake, Takara Stanley, Caroline Apovian, Shalendar Bhasin, Todd T Brown, Jaqueline Capeau, Judith S Currier, Michael P Dube, Julian Falutz, Steven K Grinspoon, Giovanni Guaraldi, Esteban Martinez, Grace A McComsey, Fred R Sattler, Kristine M Erlandson
Background: Obesity and lipohypertrophy are common in treated HIV infection and contribute to morbidity and mortality among HIV-infected adults on antiretroviral therapy (ART). Methods: We present a consensus opinion on the diagnosis, clinical consequences and treatment of excess adiposity in adults with treated HIV infection. Results: Obesity and lipohypertrophy commonly occur among HIV-infected adults on ART, and may have overlapping pathophysiologies and/or synergistic metabolic consequences...
February 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28329324/age-related-biomarkers-in-llfs-families-with-exceptional-cognitive-abilities
#3
Sandra Barral, Jatinder Singh, Erin Fagan, Stephanie Cosentino, Stacy L Andersen-Toomey, Mary K Wojczynski, Mary Feitosa, Candace M Kammerer, Nicole Schupf
Background: We previously demonstrated familial aggregation of memory performance within the Long Life Family Study (LLFS), suggesting that exceptional cognition (EC) may contribute to their exceptional longevity. Here, we investigated whether LLFS families with EC may also exhibit more favorable profiles of other age-related biomarkers. Methods: Nondemented offspring of the LLFS probands scoring 1.5 SD above the mean in a cognitive phenotype were classified as participants with EC...
March 10, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28329220/prolonged-exposures-to-intermittent-hypoxia-promote-visceral-white-adipose-tissue-inflammation-in-a-murine-model-of-severe-sleep-apnea-effect-of-normoxic-recovery
#4
Alex Gileles-Hillel, Isaac Almendros, Abdelnaby Khalyfa, Recep Nigdelioglu, Zhuanhong Qiao, Robert B Hamanaka, Gökhan M Mutlu, Mahzad Akbarpour, David Gozal
Study Objectives: Increased visceral white adipose tissue (vWAT) mass results in infiltration of inflammatory macrophages that drive inflammation and insulin resistance. Patients with obstructive sleep apnea (OSA) suffer from increased prevalence of obesity, insulin resistance and metabolic syndrome. Murine models of intermittent hypoxia (IH) mimicking moderate-severe OSA manifest insulin resistance following short-term IH. We examined in mice the effect of long-term IH on the inflammatory cellular changes within vWAT, and the potential effect of normoxic recovery (IH-R)...
December 22, 2016: Sleep
https://www.readbyqxmd.com/read/28329091/association-between-sleep-timing-obesity-diabetes-the-hispanic-community-health-study-study-of-latinos-hchs-sol-cohort-study-sleep-timing-obesity-and-diabetes
#5
Kristen L Knutson, Donghong Wu, Sanjay R Patel, Jose S Loredo, Susan Redline, Jianwen Cai, Linda C Gallo, Yasmin Mossavar-Rahmani, Alberto R Ramos, Yanping Teng, Martha L Daviglus, Phyllis C Zee
Study Objectives: Recent studies implicate inadequate sleep duration and quality in metabolic disease. Fewer studies have examined the timing of sleep, which may be important because of its potential impact on circadian rhythms of metabolic function. We examined the association between sleep timing and metabolic risk among Hispanic/Latino adults. Methods.: Cross-sectional data from community-based study of 13,429 participants aged 18-74 years. People taking diabetes medications were excluded...
January 28, 2017: Sleep
https://www.readbyqxmd.com/read/28329079/sleep-duration-and-cardiometabolic-risk-among-chinese-school-aged-children-do-adipokines-play-a-mediating-role
#6
Lujiao Li, Junling Fu, Xin Ting Yu, Ge Li, Lu Xu, Jinghua Yin, Hong Cheng, Dongqing Hou, Xiaoyuan Zhao, Shan Gao, Wenhui Li, Changhong Li, Struan F A Grant, Mingyao Li, Yi Xiao, Jie Mi, Ming Li
Objective: To assess the associations between sleep duration and cardiometabolic risk factors in Chinese school-aged children and to explore the possible mediating role of adipokines. Methods: Sleep duration was collected in 3,166 children from the Beijing Child and Adolescent Metabolic Syndrome study. Glucose homeostasis and other cardiometabolic risk factors were assessed. Serum adipokines including leptin, total and high-molecular-weight (HMW) adiponectin, resistin, fibroblast growth factor 21 (FGF21) and retinol binding protein 4 (RBP4) were determined...
March 9, 2017: Sleep
https://www.readbyqxmd.com/read/28328829/combined-effect-of-obesity-and-uric-acid-on-nonalcoholic-fatty-liver-disease-and-hypertriglyceridemia
#7
Shujun Zhang, Tingting Du, Mengni Li, Huiming Lu, Xuan Lin, Xuefeng Yu
Hyperuricemia is associated with metabolic syndrome (MetS), but the association is often confounded by the shared background of obesity. We sought to explore the modifying effects of obesity on the association between uric acid (UA), MetS components, and nonalcoholic fatty liver disease (NAFLD).We conducted a cross-sectional study in a Chinese population of 10,069 participants aged ≥20 years. Multiplicative interaction between obesity (BMI ≥25 kg/m) and elevated UA was assessed using an interaction term in a logistic regression analysis...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28328322/novel-lc-ms-ms-and-high-throughput-mass-spectrometric-assays-for-monoacylglycerol-acyltransferase-inhibitors
#8
Jenson Qi, John A Masucci, Wensheng Lang, Margery A Connelly, Gary W Caldwell, Ioanna Petrounia, Jennifer Kirkpatrick, Alexander N Barnakov, Geoffrey Struble, Robyn Miller, Keli Dzordzorine, Gee-Hong Kuo, Michael Gaul, Alessandro Pocai, Seunghun Lee
Monoacylglycerol acyltransferase enzymes (MGAT1, MGAT2, and MGAT3) convert monoacylglycerol to diacylglycerol (DAG). MGAT1 and MGAT2 are both implicated in obesity-related metabolic diseases. Conventional MGAT enzyme assays use radioactive substrates, wherein the product of the MGAT-catalyzed reaction is usually resolved by time-consuming thin layer chromatography (TLC) analysis. Furthermore, microsomal membrane preparations typically contain endogenous diacylglycerol acyltransferase (DGAT) from the host cells, and these DGAT activities can further acylate DAG to form triglyceride (TG)...
April 2017: SLAS Discov
https://www.readbyqxmd.com/read/28327832/-frequency-of-metabolic-syndrome-in-residents-of-an-andean-region-in-peru
#9
Juana Aurelia Ninatanta-Ortiz, Luz Amparo Núñez-Zambrano, Segunda Aydeé García-Flores, Franco Romaní Romaní
Objectives.: To calculate the frequency of metabolic syndrome (MetS) and its associated characteristics in selected populations residing in the urban areas of two districts in the Cajamarca region. Materials and methods.: Cross-sectional study performed in 2014, obtaining randomized samples from three target study populations: high school students, university students, and schoolchildren mothers. In adults, MetS was defined by means of Third Adult Treatment Panel (ATP III) criteria, and in teenagers, the modified Cook criteria were used...
October 2016: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/28327822/impact-of-roux-en-y-gastric-bypass-surgery-rygb-on-metabolic-syndrome-components-and-on-the-use-of-associated-drugs-in-obese-patients
#10
Vilma Maria Junges, Jarbas Marinho Cavalheiro, Eliana Franzoi Fam, Vera Elizabeth Closs, João Feliz Moraes, Maria Gabriela Gottlieb
BACKGROUND: The prevalence of obesity and metabolic syndrome is increasing worldwide and both behavior modification and drug therapy have low adherence. Gastric bypass has shown effective results in both reducing weight and improving comorbidities. OBJECTIVE: To evaluate the impact of Roux-en-Y Gastric Bypass Surgery (RYGB) on both metabolic syndrome components and the use of associated drugs in obese patients. METHODS: Historical cohort of patients subjected to Roux-en-Y Gastric Bypass Surgery (RYGB) between January 2007 and March 2014 in a private clinic...
March 16, 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28327709/fish-oil-supplementation-inhibits-endoplasmic-reticulum-stress-and-improves-insulin-resistance-involvement-of-amp-activated-protein-kinase
#11
Wenqi Yang, Xu Chen, Ming Chen, Yanping Li, Qing Li, Xinwei Jiang, Yan Yang, Wenhua Ling
The beneficial effects of fish oil consumption on glucose metabolism have been generally reported. However, the mechanism underlying the fish oil-induced protective effects against insulin resistance remains unclear. Endoplasmic reticulum (ER) stress is recognized as an important contributor to insulin resistance. The aim of this study is to evaluate whether fish oil supplementation reduces ER stress and ameliorates insulin resistance in diet-induced obese mice, and to investigate the molecular mechanism of fish oil-induced benefits on ER stress...
March 22, 2017: Food & Function
https://www.readbyqxmd.com/read/28327588/pharmacological-inhibition-of-adipose-triglyceride-lipase-corrects-high-fat-diet-induced-insulin-resistance-and-hepatosteatosis-in-mice
#12
Martina Schweiger, Matthias Romauch, Renate Schreiber, Gernot F Grabner, Sabrina Hütter, Petra Kotzbeck, Pia Benedikt, Thomas O Eichmann, Sohsuke Yamada, Oskar Knittelfelder, Clemens Diwoky, Carina Doler, Nicole Mayer, Werner De Cecco, Rolf Breinbauer, Robert Zimmermann, Rudolf Zechner
Elevated circulating fatty acids (FAs) contribute to the development of obesity-associated metabolic complications such as insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD). Hence, reducing adipose tissue lipolysis to diminish the mobilization of FAs and lower their respective plasma concentrations represents a potential treatment strategy to counteract obesity-associated disorders. Here we show that specific inhibition of adipose triglyceride lipase (Atgl) with the chemical inhibitor, Atglistatin, effectively reduces adipose tissue lipolysis, weight gain, IR and NAFLD in mice fed a high-fat diet...
March 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28327129/short-term-overfeeding-of-zebrafish-with-normal-or-high-fat-diet-as-a-model-for-the-development-of-metabolically-healthy-versus-unhealthy-obesity
#13
Kathrin Landgraf, Susanne Schuster, Andrej Meusel, Antje Garten, Thomas Riemer, Dorit Schleinitz, Wieland Kiess, Antje Körner
BACKGROUND: Obese individuals differ in their risk of developing metabolic and cardiovascular complications depending on fat distribution (subcutaneous versus visceral) and adipose tissue (AT) phenotype (hyperplasic versus hypertrophic). However, the exact mechanisms which determine whether an obese individual is metabolically healthy or unhealthy are not clear, and analyses of the underlying pathomechanisms are limited by the lack of suitable in vivo models in which metabolically healthy versus metabolically unhealthy AT accumulation can be specifically induced...
March 21, 2017: BMC Physiology
https://www.readbyqxmd.com/read/28326296/association-between-sarcopenic-obesity-and-metabolic-syndrome-in-postmenopausal-women-a-cross-sectional-study-based-on-the-korean-national-health-and-nutritional-examination-surveys-from-2008-to-2011
#14
Sun-Young Kang, Gyeong Eun Lim, Yang Keun Kim, Hye Won Kim, Kayoung Lee, Tae-Jin Park, Jinseung Kim
BACKGROUND: Menopause contributes to an increase in visceral fat mass and a decrease in muscle protein synthesis. Therefore, we performed this study to examine their relationship how effect the changes of body composition as obesity and sarcopenia on metabolic syndrome (MS) as a predictor of cardiovascular disease in postmenopausal women. METHODS: Using data from the Korean National Health and Nutrition Examination Survey (KNHANES) from 2008 to 2011, we estimated that 4,183 postmenopausal women underwent dual energy X-ray absorptiometry scans...
February 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/28325853/deletion-of-macrophage-mineralocorticoid-receptor-protects-hepatic-steatosis-and-insulin-resistance-through-er%C3%AE-hgf-met-pathway
#15
Yu-Yao Zhang, Chao Li, Gao-Feng Yao, Lin-Juan Du, Yuan Liu, Xiao-Jun Zheng, Shuai Yan, Jian-Yong Sun, Yan Liu, Ming-Zhu Liu, Xiaoran Zhang, Gang Wei, Wenxin Tong, Xiaobei Chen, Yong Wu, Shuyang Sun, Suling Liu, Qiurong Ding, Ying Yu, Huiyong Yin, Sheng-Zhong Duan
Although the importance of macrophages in nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) has been recognized, it remains elusive how macrophages impact hepatocytes. Mineralocorticoid receptor (MR) has been implied to play important roles in NAFLD and T2DM. However, cellular and molecular mechanisms are largely unknown. Here we report that myeloid MR knockout (MRKO) improves glucose intolerance, insulin resistance, and hepatic steatosis in obese mice. Estrogen signaling is sufficient and necessary for such improvements...
March 21, 2017: Diabetes
https://www.readbyqxmd.com/read/28325733/overactivation-of-the-endocannabinoid-system-alters-the-anti-lipolytic-action-of-insulin-in-mouse-adipose-tissue
#16
Tania Muller, Laurent Demizieux, Stéphanie Troy-Fioramonti, Joseph Gresti, Jean-Paul Pais de Barros, Hélène Berger, Bruno Vergès, Pascal Degrace
Evidence has accumulated that obesity-related metabolic dysregulation is associated with overactivation of the endocannabinoid system (ECS), which involves cannabinoid receptor 1 (CB1R), in peripheral tissues, including adipose tissue (AT). The functional consequences of CB1R activation on AT metabolism remain unclear. Since excess fat mobilization is considered an important primary event contributing to the onset of insulin resistance, we combined in vivo and in vitro experiments to investigate whether activation of ECS could alter the lipolytic rate...
March 21, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28325521/the-role-of-adipokines-in-cardiovascular-disease
#17
REVIEW
Rei Shibata, Noriyuki Ouchi, Koji Ohashi, Toyoaki Murohara
Obesity leads to the development of cardiovascular diseases. Adipose tissue produces various bioactive molecules, also known as adipokines, and imbalanced production of adipokines contributes to the pathogenesis of obesity-linked metabolic and cardiovascular complications. Some adipokines such as adiponectin exert salutary actions on cardiovascular and metabolic disorders. Recent research has been conducted to identify poorly-characterized adipokines involved in cardiovascular regulation. In this review, we focus on the protective role of novel adipokines that are of current interest in the field of cardiology...
March 18, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28325221/is-metabolic-dysregulation-associated-with-antidepressant-response-in-depressed-women-in-climacteric-treated-with-individualized-homeopathic-medicines-or-fluoxetine-the-homdep-menop-study
#18
Emma Del Carmen Macías-Cortés, Lidia Llanes-González, Leopoldo Aguilar-Faisal, Juan Asbun-Bojalil
BACKGROUND: Climacteric is associated with both depression and metabolic dysregulation. Scarce evidence suggests that metabolic dysregulation may predict poor response to conventional antidepressants. Response to depression treatment has not been studied in homeopathic medicine. The aim of this study was to investigate the prevalence of metabolic disorders in depressed climacteric women treated with homeopathic medicines, fluoxetine or placebo, and if these alterations have any association with response to depression treatment...
February 2017: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/28325141/effect-of-intranasal-administration-of-galanin-like-peptide-galp-on-body-weight-and-hepatic-lipids-accumulation-in-mice-with-diet-induced-obesity
#19
Satoshi Hirako, Nobuhiro Wada, Haruaki Kageyama, Fumiko Takenoya, Hyounju Kim, Yuzuru Iizuka, Akiyo Matsumoto, Mai Okabe, Seiji Shioda
Galanin-like peptide (GALP) is a neuropeptide involved in the regulation of food intake behavior, body weight and energy metabolism. In previous studies, we demonstrated that the intranasal administration of GALP has weight loss effects, although the mechanism of this action was not clarified. The aim of this study was to demonstrate the functional significance of GALP on lipid metabolism in the liver. Mice were fed a high fat diet to cause diet-induced obesity (DIO) and then administered GALP intranasally for 2 weeks (experimental), or vehicle (control)...
March 20, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28324798/conservative-management-of-an-unusual-bilioduodenal-fistula-post-laparoscopic-duodeno-ileal-switch-sadi-s-case-report
#20
E Chelala, E Adam, A Rizk, E Makhoul
INTRODUCTION: Single anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) is an advanced operation for morbid obesity. To our knowledge, no internal Biliodigestive Fistula has yet been reported as specific complication in the field of metabolic and bariatric Biliopancreatic diversion. CASE PRESENTATION: In this case report, we detail the case of a 57-year-old man who underwent a Single Anastomosis Duodeno-Ileal Switch (SADI-S) bariatric procedure for morbid obesity...
March 6, 2017: International Journal of Surgery Case Reports
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