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https://www.readbyqxmd.com/read/28107763/virtual-chromoendoscopy-i-scan-detects-more-polyps-in-patients-with-lynch-syndrome-a-randomized-controlled-crossover-trial
#1
Raf Bisschops, Sabine Tejpar, Hilde Willekens, Gert De Hertogh, Eric Van Cutsem
: Background and study aims (Virtual) chromoendoscopy detects more polyps than standard white-light endoscopy in patients with Lynch syndrome. Previous back-to-back trials did not randomize for the examination order, creating a possible bias in favor of chromoendoscopy. We aimed to assess the difference in polyp detection between high definition white-light endoscopy (HD-WLE) and virtual chromoendoscopy with I-SCAN in patients with Lynch syndrome. Patients and methods In this prospective, controlled trial, patients were randomized to either HD-WLE followed by I-SCAN (Group 1; n = 31) or I-SCAN followed by HD-WLE (Group 2; n = 30)...
January 20, 2017: Endoscopy
https://www.readbyqxmd.com/read/28107273/influence-of-depth-of-hypnosis-on-pupillary-reactivity-to-a-standardized-tetanic-stimulus-in-patients-under-propofol-remifentanil-target-controlled-infusion-a-crossover-randomized-pilot-study
#2
Nada Sabourdin, Jean-Baptiste Peretout, Eliane Khalil, Marie-Laurence Guye, Nicolas Louvet, Isabelle Constant
BACKGROUND: Pupillometry allows the measurement of pupillary diameter variations in response to nociceptive stimuli. This technique has been used to monitor the balance between analgesia and nociception. Under general anesthesia, the amplitude of pupillary dilation is related to the amount of administered opioids. The objective of this study was to determine whether at a constant infusion rate of opioids, the pupillary response was influenced by depth of hypnosis assessed by the bispectral index (BIS)...
January 19, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28106611/time-course-of-copeptin-during-a-model-of-experimental-pain-and-hyperalgesia-a-randomised-volunteer-crossover-trial
#3
Eckhard Mauermann, Claudine A Blum, Giovanna Lurati Buse, Oliver Bandschapp, Wilhelm Ruppen
BACKGROUND: A reliable biomarker for quantifying pain or hyperalgesia has yet to be found. A surrogate marker of arginine vasopressin, copeptin, is elevated in a number of states of physiological and psychological stress and may have a role in quantifying pain and/or hyperalgesia. OBJECTIVES: To evaluate copeptin as a biomarker for pain or hyperalgesia developing after 120 min of sustained electrical stimulation. DESIGN: Secondary analysis of a randomised, double-blinded, crossover trial...
January 19, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28106588/technology-based-healthcare-for-nursing-education-within-the-netherlands-past-present-and-future
#4
Ybranda Koster, Cornelis T M van Houwelingen
At the present time, nearly all Dutch nursing schools are searching for suitable ways to implement technology-based healthcare in their curriculum. Some Universities chose elective education, others a mandatory solution. Several studies were executed to determine competencies needed by nurses in order to work with technology-based healthcare. In 2016 a nationwide new curriculum for nurses has been published. Providing technology-based healthcare is included under the core competencies of this new curriculum...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28105763/triggering-of-acute-myocardial-infarction-by-respiratory-infection
#5
Lorcan Ruane, Thomas Buckley, Soon Y Soo Hoo, Peter S Hansen, Catherine McCormack, Elizabeth Shaw, Judith Fethney, Geoffrey H Tofler
BACKGROUND: Respiratory infection has been associated with an increased short term risk of myocardial infarction (MI). However, previous studies have predominantly been conducted without angiographic confirmation of MI. The possibility can therefore not be excluded that raised troponin levels or electrocardiogram abnormalities that may be seen with respiratory infections are due to non-ischaemic causes. AIMS: To investigate the association between respiratory infection and angiographically confirmed MI...
January 20, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28105705/urinary-fluoride-excretion-after-application-of-fluoride-varnish-and-use-of-fluoride-toothpaste-in-young-children
#6
Frida Lockner, Svante Twetman, Christina Stecksén-Blicks
BACKGROUND: The efficacy and safety of combined use of topical fluoride products are essential issues that must be monitored. AIM: To assess urinary excretion of fluoride after application of two different dental varnishes containing 2.26% fluoride in 3- to 4-year-old children and to compare the levels with and without parallel use of fluoride toothpaste. DESIGN: Fifteen healthy children were enrolled to a randomized crossover trial that was performed in two parts: Part I with twice-daily tooth brushing with fluoride toothpaste and Part II with twice-daily brushing with a non-fluoride toothpaste...
January 20, 2017: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/28104353/fluid-energy-and-nutrient-recovery-via-ad-libitum-intake-of-different-fluids-and-food
#7
Nadia Campagnolo, Elizaveta Iudakhina, Christopher Irwin, Matthew Schubert, Gregory R Cox, Michael Leveritt, Ben Desbrow
INTRODUCTION: This study compared the effects of ad libitum consumption of different beverages and foods on fluid retention and nutrient intake following exercise. METHODS: Ten endurance trained males (mean±SD; Age=25.3±4.9years, VO2max=63.0±7.2ml·kg·min(-1)) performed four trials employing a counterbalanced, crossover design. Following 60min of exercise (matched for energy expenditure and fluid loss) participants consumed either water (W1 and W2), a sports drink (Powerade® (P)) or a milk-based liquid meal supplement (Sustagen Sport® (SS)) over a four hour recovery period...
January 16, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28104287/enhanced-terminal-room-disinfection-and-acquisition-and-infection-caused-by-multidrug-resistant-organisms-and-clostridium-difficile-the-benefits-of-enhanced-terminal-room-disinfection-study-a-cluster-randomised-multicentre-crossover-study
#8
Deverick J Anderson, Luke F Chen, David J Weber, Rebekah W Moehring, Sarah S Lewis, Patricia F Triplett, Michael Blocker, Paul Becherer, J Conrad Schwab, Lauren P Knelson, Yuliya Lokhnygina, William A Rutala, Hajime Kanamori, Maria F Gergen, Daniel J Sexton
BACKGROUND: Patients admitted to hospital can acquire multidrug-resistant organisms and Clostridium difficile from inadequately disinfected environmental surfaces. We determined the effect of three enhanced strategies for terminal room disinfection (disinfection of a room between occupying patients) on acquisition and infection due to meticillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, C difficile, and multidrug-resistant Acinetobacter. METHODS: We did a pragmatic, cluster-randomised, crossover trial at nine hospitals in the southeastern USA...
January 16, 2017: Lancet
https://www.readbyqxmd.com/read/28104253/the-effect-of-fampridine-sr-on-cognitive-fatigue-in-a-randomized-double-blind-crossover-trial-in-patients-with-ms
#9
Sarah A Morrow, Heather Rosehart, Andrew M Johnson
BACKGROUND: Cognitive fatigue (CF) is a common complaint in persons with MS (PwMS). Fampridine-SR improves ambulation, fatigue and endurance, due to enhancing action potential formation by blocking potassium channels in demyelinated axons. Thus, through this same mechanism, it is hypothesized that Fampridine-SR could improve CF. OBJECTIVE: To determine if Fampridine-SR objectively improves CF in PwMS. METHODS: Sixty PwMS of any type with CF, defined as 3 or less correct responses when comparing the last third to the first third on the Paced Auditory Serial Addition Test (PASAT), were recruited from a tertiary care MS clinic in London (ON) Canada...
January 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28103698/histamine-applied-topically-to-the-nasal-mucosa-increases-the-transmucosal-nitrous-oxide-exchange-for-the-middle-ear
#10
Miriam S Teixeira, Cuneyt M Alper, Brian S Martin, Selma Cetin, Jenna A El-Wagaa, William J Doyle
OBJECTIVE: Determine if the middle ear transmucosal nitrous oxide (N2O) exchange rate is affected by nasal inflammation caused by topical application of histamine. METHODS: In a randomized, double-blind, crossover study, 20 adults were challenged intranasally with histamine (5 mg) and placebo on separate occasions. At each session, the subjects were fitted with a non-rebreathing mask and breathed room air for 20 minutes, 50% N2O:50% O2 for 20 minutes, and 100% O2 for 10 minutes...
January 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28103198/harmonious-genetic-clustering
#11
Faliang Huang, Xuelong Li, Shichao Zhang, Jilian Zhang
To automatically determine the number of clusters and generate more quality clusters while clustering data samples, we propose a harmonious genetic clustering algorithm, named HGCA, which is based on harmonious mating in eugenic theory. Different from extant genetic clustering methods that only use fitness, HGCA aims to select the most suitable mate for each chromosome and takes into account chromosomes gender, age, and fitness when computing mating attractiveness. To avoid illegal mating, we design three mating prohibition schemes, i...
January 5, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28102397/highly-exposed-fe-n4-active-sites-in-porous-poly-iron-phthalocyanine-based-oxygen-reduction-electrocatalyst-with-ultrahigh-performance-for-air-cathode
#12
Ganesan Anandhababu, Syed Comail Abbas, Jiangquan Lv, Kui Ding, Qin Liu, Dickson D Babu, Yiyin Huang, Jiafang Xie, Maoxiang Wu, Yaobing Wang
Progress in the development of efficient electrocatalysts for oxygen reduction reactions is imperative for various energy systems such as metal-air batteries and fuel cells. In this paper, an innovative porous two-dimensional (2D) poly-iron-phthalocyanine (PFe-Pc) based oxygen reduction electrocatalyst created with a simple solid-state chemical reaction without pyrolysis is reported. In this strategy, silicon dioxide nanoparticles play a pivotal role in preserving the Fe-N4 structure during the polymerization process and thereby assist in the development of a porous structure...
January 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28102097/familiar-auditory-sensory-training-in-chronic-traumatic-brain-injury-a-case-study
#13
Emily Galassi Sullivan, Ann Guernon, Brett Blabas, Amy A Herrold, Theresa L-B Pape
PURPOSE: The evaluation and treatment for patients with prolonged periods of seriously impaired consciousness following traumatic brain injury (TBI), such as a vegetative or minimally conscious state, poses considerable challenges, particularly in the chronic phases of recovery. METHOD: This blinded crossover study explored the effects of familiar auditory sensory training (FAST) compared with a sham stimulation in a patient seven years post severe TBI. Baseline data were collected over 4 weeks to account for variability in status with neurobehavioral measures, including the Disorders of Consciousness scale (DOCS), Coma Near Coma scale (CNC), and Consciousness Screening Algorithm...
January 19, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28101670/recombination-correlates-with-synaptonemal-complex-length-and-chromatin-loop-size-in-bovids-insights-into-mammalian-meiotic-chromosomal-organization
#14
Aurora Ruiz-Herrera, Miluse Vozdova, Jonathan Fernández, Hana Sebestova, Laia Capilla, Jan Frohlich, Covadonga Vara, Adrià Hernández-Marsal, Jaroslav Sipek, Terence J Robinson, Jiri Rubes
Homologous chromosomes exchange genetic information through recombination during meiosis, a process that increases genetic diversity, and is fundamental to sexual reproduction. In an attempt to shed light on the dynamics of mammalian recombination and its implications for genome organization, we have studied the recombination characteristics of 112 individuals belonging to 28 different species in the family Bovidae. In particular, we analyzed the distribution of RAD51 and MLH1 foci during the meiotic prophase I that serve, respectively, as proxies for double-strand breaks (DSBs) which form in early stages of meiosis and for crossovers...
January 18, 2017: Chromosoma
https://www.readbyqxmd.com/read/28100637/a-zip3-like-protein-plays-a-role-in-crossover-formation-in-the-sc-less-meiosis-of-the-protist-tetrahymena
#15
Anura Shodhan, Kensuke Kataoka, Kazufumi Mochizuki, Maria Novatchkova, Josef Loidl
When programmed meiotic DNA double-strand breaks (DSBs) undergo recombinational repair, genetic crossovers (COs) may be formed. A certain level of these are required for the faithful segregation of chromosomes, but the majority of DSBs are processed toward a safer alternative, namely non-crossovers (NCOs), via non-reciprocal DNA exchange. At the crossroads between these two DSB fates are the Msh4-Msh5 (MutSγ) complex, which stabilizes CO-destined recombination intermediates, and members of the Zip3/RNF212 family of RING finger proteins, which in turn stabilize MutSγ...
January 18, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28100415/a-10-year-trend-of-dental-treatments-under-general-anesthesia-of-children-in-taipei-veterans-general-hospital
#16
Yung-Pan Chen, Chun-Yi Hsieh, Wen-Ting Hsu, Fu-Ya Wu, Wen-Yu Shih
BACKGROUND: General anesthesia (GA) as a pediatric dental procedure is a well-established method of behavior management. However, studies of pediatric dentistry under GA have mostly focused on handicapped patients, and various retrospective studies in Taiwan have mainly reviewed only a limited number of years. The purpose of the present study was to report trends in pediatric dental treatment performed under GA over the past 10 years. METHODS: A retrospective review of the hospital records of patients receiving dental treatment under GA from 2006 until 2015 was performed...
January 16, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28100212/the-effects-of-breakfast-on-short-term-cognitive-function-among-chinese-white-collar-workers-protocol-for-a-three-phase-crossover-study
#17
Zhenchuang Tang, Na Zhang, Ailing Liu, Dechun Luan, Yong Zhao, Chao Song, Guansheng Ma
BACKGROUND: As the first meal of the day, breakfast plays an important role in supplying energy and nutrients, which are critical to working and learning activities. A three-phase crossover study was designed to investigate the effects of breakfast on cognitive function among Chinese white-collar workers. The planned study protocol is presented. METHODS: A total of 264 participants aged 25-45 years will be recruited from Shenyang and Chongqing. Self-administered questionnaires will be used to collect information on age, gender, marital status, education level, occupation, smoking habits, drinking habits, and breakfast behaviours...
January 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28099755/comparing-effects-of-insulin-analogues-and-human-insulin-on-nocturnal-glycaemia-in-hypoglycaemia-prone-people-with-type-1-diabetes
#18
P L Kristensen, L Tarnow, C Bay, K Nørgaard, T Jensen, H-H Parving, H Perrild, H Beck-Nielsen, J S Christiansen, B Thorsteinsson, U Pedersen-Bjergaard
AIMS: To assess the difference between analogue and human insulin with regard to nocturnal glucose profiles and risk of hypoglycaemia in people with recurrent severe hypoglycaemia. METHODS: A total of 72 people [46 men, mean ± sd age 54 ± 12 years, mean ± sd HbA1c 65 ± 12 mmol/mol (8.1 ± 1.1%), mean ± sd duration of diabetes 30 ± 14 years], who participated in a 2-year randomized, crossover trial of basal-bolus therapy with insulin detemir/insulin aspart or human NPH insulin/human regular insulin (the HypoAna trial) were studied for 2 nights during each treatment...
January 18, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28099472/elastic-tape-improved-shoulder-joint-position-sense-in-chronic-hemiparetic-subjects-a-randomized-sham-controlled-crossover-study
#19
Gabriela Lopes Dos Santos, Matheus Bragança Souza, Kaat Desloovere, Thiago Luiz Russo
BACKGROUND: Elastic tape has been widely used in clinical practice in order to improve upper limb (UL) sensibility. However, there is little evidence that supports this type of intervention in stroke patients. OBJECTIVE: To verify the effect of elastic tape, applied to the paretic shoulder, on joint position sense (JPS) during abduction and flexion in subjects with chronic hemiparesis compared to sham tape (non-elastic tape). Furthermore, to verify if this potential effect is correlated to shoulder subluxation measurements and sensorimotor impairment...
2017: PloS One
https://www.readbyqxmd.com/read/28099372/effect-of-sequence-of-simulated-and-clinical-practicum-learning-experiences-on-clinical-competency-of-nursing-students
#20
Jamie Hansen, Marilyn Bratt
Two different sequences of blocks of simulated and clinical practicum learning experiences compared the clinical competency development of nursing students using a randomized crossover design. Competency was measured 3 times: after each block of simulated and clinical experiences and after a final simulated experience. No significant differences in competency scores between the 2 groups across the 3 time points were found. Using alternative models of clinical and simulation learning may help address barriers to the delivery of clinical education faced by schools of nursing...
January 18, 2017: Nurse Educator
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