keyword
https://read.qxmd.com/read/38532508/mrc1-and-lyve1-expressing-macrophages-in-vascular-beds-of-gnaq-p-r183q-driven-capillary-malformations-in-sturge-weber-syndrome
#21
JOURNAL ARTICLE
Sana Nasim, Colette Bichsel, Stephen Dayneka, Robert Mannix, Annegret Holm, Mathew Vivero, Sanda Alexandrescu, Anna Pinto, Arin K Greene, Donald E Ingber, Joyce Bischoff
Sturge-Weber syndrome (SWS), a neurocutaneous disorder, is characterized by capillary malformations (CM) in the skin, brain, and eyes. Patients may suffer from seizures, strokes, and glaucoma, and only symptomatic treatment is available. CM are comprised of enlarged vessels with endothelial cells (ECs) and disorganized mural cells. Our recent finding indicated that the R183Q mutation in ECs leads to heightened signaling through phospholipase Cβ3 and protein kinase C, leading to increased angiopoietin-2 (ANGPT2)...
March 26, 2024: Acta Neuropathologica Communications
https://read.qxmd.com/read/38532410/wnt5a-%C3%AE-catenin-mediated-epithelial-mesenchymal-transition-a-key-driver-of-subretinal-fibrosis-in-neovascular-age-related-macular-degeneration
#22
JOURNAL ARTICLE
Dandan Liu, Jingxiao Du, Hai Xie, Haibin Tian, Lixia Lu, Chaoyang Zhang, Guo-Tong Xu, Jingfa Zhang
BACKGROUND: Neovascular age-related macular degeneration (nAMD), accounts for up to 90% of AMD-associated vision loss, ultimately resulting in the formation of fibrotic scar in the macular region. The pathogenesis of subretinal fibrosis in nAMD involves the process of epithelial-mesenchymal transition (EMT) occurring in retinal pigment epithelium (RPE). Here, we aim to investigate the underlying mechanisms involved in the Wnt signaling during the EMT of RPE cells and in the pathological process of subretinal fibrosis secondary to nAMD...
March 26, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38532242/ace2-rescues-sepsis-associated-encephalopathy-by-reducing-inflammation-oxidative-stress-and-neuronal-apoptosis-via-the-nrf2-sestrin2-signaling-pathway
#23
JOURNAL ARTICLE
Ya Li, Tian-Tian Wan, Jia-Xin Li, Xue Xiao, Lei Liu, Hui-Hua Li, Shu-Bin Guo
Neuroinflammation and oxidative stress contribute to the progression of sepsis-associated encephalopathy (SAE). Angiotensin-converting enzyme 2 (ACE2) is considered to be a neuroprotective factor due to its anti-inflammatory and antioxidant properties. However, the role of ACE2 on myeloid cells in regulating SAE and the underlying mechanism warrants further exploration. SAE was induced in ACE2 transgenic (TG), knockout (KO), and bone marrow (BM) chimeric mice by cecal ligation and puncture (CLP). The expression levels of apoptosis-, oxidation- and neuroinflammation-associated mediators and morphological changes were monitored by quantitative real-time PCR analyses and histological examinations in the cortex of septic mice...
March 27, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38532152/protective-effect-of-silibinin-on-lipopolysaccharide-induced-endotoxemia-by-inhibiting-caspase-11-dependent-cell-pyroptosis
#24
JOURNAL ARTICLE
Jin-Ying Ou, Shan-Hong Liu, Dong-Kai Tang, Ling-Zhu Shi, Li-Jun Yan, Jing-Yan Huang, Li-Fang Zou, Jing-Yu Quan, Yan-Ting You, Yu-Yao Chen, Lin-Zhong Yu, Zi-Bin Lu
OBJECTIVE: To explore the protective effect and the underlying mechanism of silibinin (SIB), one of the active compounds from Silybum marianum (L.) Gaertn in endotoxemia. METHODS: Mouse peritoneal macrophage were isolated via intraperitoneally injection of BALB/c mice with thioglycolate medium. Cell viability was assessed using the cell counting kit-8, while cytotoxicity was determined through lactate dehydrogenase cytotoxicity assay. The protein expressions of interleukin (IL)-1 α, IL-1 β, and IL-18 were determined by enzyme-linked immunosorbent assay...
March 27, 2024: Chinese Journal of Integrative Medicine
https://read.qxmd.com/read/38532054/atp-releasing-channels-and-the-ameliorative-effects-of-high-intensity-interval-training-on-diabetic-heart-a-multifaceted-analysis
#25
JOURNAL ARTICLE
Siyavash Joukar, Mohammad Amin Rajizadeh, Mohammad Abbas Bejeshk, Samaneh Sadat Alavi, Fatemeh Bagheri, Mohammad Rami, Kayvan Khoramipour
Type 2 diabetes (T2D) can cause severe cardiac complications at functional, histologic and molecular levels. These pathological complications could be mediated by ATP-releasing channels such as Panx1 and ATP receptors, in particular P2X7. The aim of our study was to investigate the effect of high-intensity interval training (HIIT) on T2D-induced cardiac complications at the functional, histopathological and molecular levels, with a particular focus on ATP-releasing channels. 48 male Wistar rats at the age of 8 weeks were randomly allocated into four groups: control (Con), Diabetes (T2D), Training (TR), and Diabetes + Training (T2D + TR)...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531523/diosgenin-loaded-cellulose-nanoonion-impedes-different-stages-of-protein-aggregation-induced-cell-death-via-alleviating-mitochondrial-dysfunction-and-upregulation-of-autophagy
#26
JOURNAL ARTICLE
Syed M S Abidi, Ashish K Shukla, Shiwani Randhawa, Manik Bathla, Amitabha Acharya
Protein aggregation is a multifaceted phenomenon prevalent in the progression of neurodegenerative diseases, yielding aggregates of diverse sizes. Recently, increased attention has been directed towards early protein aggregates due to their pronounced toxicity, largely stemming from inflammation mediated by reactive oxygen species (ROS). This study advocates for a therapeutic approach focusing on inflammation control rather than mere ROS inhibition in the context of neurodegenerative disorders. Here, we introduced Camellia sinensis cellulose nanoonion (CS-CNO) as an innovative, biocompatible nanocarrier for encapsulating the phytosteroid diosgenin (DGN@CS-CNO)...
March 24, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38531522/chitosan-thermogelation-and-cascade-mineralization-via-sequential-caco-3-incorporations-for-wound-care
#27
JOURNAL ARTICLE
Chengkun Liu, Menghan Li, Zhiyuan Liu, Zhuang Shi, Xiaoqiang Wang, Fang Huang
Physically crosslinked hydrogels have shown great potential as excellent and eco-friendly matrices for wound management. Herein, we demonstrate the development of a thermosensitive chitosan hydrogel system using CaCO3 as a gelling agent, followed by CaCO3 mineralization to fine-tune its properties. The chitosan hydrogel effectively gelled at 37 °C and above after an incubation period of at least 2 h, facilitated by the CaCO3 -mediated slow deprotonation of primary amine groups on chitosan polymers...
March 24, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38531361/twin-study-dissects-cxcr3-memory-b-cells-as-non-heritable-feature-in-multiple-sclerosis
#28
JOURNAL ARTICLE
Florian Ingelfinger, Kirsten L Kuiper, Can Ulutekin, Lukas Rindlisbacher, Sarah Mundt, Lisa Ann Gerdes, Joost Smolders, Marvin M van Luijn, Burkhard Becher
BACKGROUND: In multiple sclerosis (MS), B cells are considered main triggers of the disease, likely as the result of complex interaction between genetic and environmental risk factors. Studies on monozygotic twins discordant for MS offer a unique way to reduce this complexity and reveal discrepant subsets. METHODS: In this study, we analyzed B cell subsets in blood samples of monozygotic twins with and without MS using publicly available data. We verified functional characteristics by exploring the role of therapy and performed separate analyses in unrelated individuals...
March 18, 2024: Med
https://read.qxmd.com/read/38531065/evidence-that-keratinocyte-microvesicle-particles-carrying-platelet-activating-factor-mediate-the-widespread-multi-organ-damage-associated-with-intoxicated-thermal-burn-injury
#29
JOURNAL ARTICLE
Rushabh P Lohade, Chad Brewer, Christine M Rapp, Karen M Henkels, Wenfeng Zhang, Anita Thyagarajan, Shikshita Singh, Pranali Manjrekar, Taskin Sabit, Ravi P Sahu, Jeffrey B Travers
Thermal burn injuries can result in significant morbidity and mortality. The combination of ethanol intoxication with thermal burn injury results in increased morbidity through an exaggerated inflammatory response involving many organs. Recent studies have linked involvement of the lipid mediator Platelet-activating factor (PAF) in the pathology associated with intoxicated thermal burn injury (ITBI). The present studies tested the roles of PAF and the elevated levels of subcellular microvesicle particles (MVP) generated in response to ITBI in the subsequent multi-organ toxicity...
March 26, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38530976/exosomes-derived-from-caerulein-stimulated-pancreatic-acinar-cells-mediate-peritoneal-macrophage-m1-polarization-and-pyroptosis-via-an-mir-24-3p-march3-nlrp3-axis-in-acute-pancreatitis
#30
JOURNAL ARTICLE
Xiao-Ju Su, Yan Chen, Qi-Chen Zhang, Xiao-Bo Peng, Ya-Ping Liu, Lei Wang, Yi-Qi Du
OBJECTIVES: Acute pancreatitis (AP) has a high incidence of hospitalizations, morbidity, and mortality worldwide. A growing number of studies on AP pathogenesis are based on caerulein-induced experimental model, which simulates human AP in vivo. It has been demonstrated that both pancreatic acinar cells and peritoneal macrophages are involved in pancreatic inflammation and damage. However, their connection has not been well understood. METHODS: A caerulein-induced AP model was established on the pancreatic acinar cell line AR42J...
March 27, 2024: Pancreas
https://read.qxmd.com/read/38530880/glucosylceramide-accumulation-in-microglia-triggers-sting-dependent-neuroinflammation-and-neurodegeneration-in-mice
#31
JOURNAL ARTICLE
Rui Wang, Hongyang Sun, Yifan Cao, Zhixiong Zhang, Yajing Chen, Xiying Wang, Lele Liu, Jin Wu, Hao Xu, Dan Wu, Chenchen Mu, Zongbing Hao, Song Qin, Haigang Ren, Junhai Han, Ming Fang, Guanghui Wang
Mutations in the gene encoding the lysosomal enzyme glucocerebrosidase (GCase) are responsible for Gaucher disease (GD) and are considered the strongest genetic risk factor for Parkinson's disease (PD) and Lewy body dementia (LBD). GCase deficiency leads to extensive accumulation of glucosylceramides (GCs) in cells and contributes to the neuropathology of GD, PD, and LBD by triggering chronic neuroinflammation. Here, we investigated the mechanisms by which GC accumulation induces neuroinflammation. We found that GC accumulation within microglia induced by pharmacological inhibition of GCase triggered STING-dependent inflammation, which contributed to neuronal loss both in vitro and in vivo...
March 26, 2024: Science Signaling
https://read.qxmd.com/read/38530808/macrophages-suppress-cardiac-reprogramming-of-fibroblasts-in-vivo-via-ifn-mediated-intercellular-self-stimulating-circuit
#32
JOURNAL ARTICLE
Hao Wang, Junbo Yang, Yihong Cai, Yang Zhao
Direct conversion of cardiac fibroblasts (CFs) to cardiomyocytes (CMs) in vivo to regenerate heart tissue is an attractive approach. After myocardial infarction (MI), heart repair proceeds with an inflammation stage initiated by monocytes infiltration of the infarct zone establishing an immune microenvironment. However, whether and how the MI microenvironment influences the reprogramming of CFs remains unclear. Here, we found that in comparison with cardiac fibroblasts (CFs) cultured in vitro, CFs that transplanted into infarct region of MI mouse models resisted to cardiac reprogramming...
March 26, 2024: Protein & Cell
https://read.qxmd.com/read/38530797/geraniin-alleviates-inflammation-in-caco-2-cells-and-dextran-sulfate-sodium-induced-colitis-mice-by-targeting-il-1%C3%AE
#33
JOURNAL ARTICLE
Hae-Ri Lee, Young-Jin Jeong, Sun-Ae Park, Hee Jung Kim, Tae-Hwe Heo
IL-1β is an important cytokine implicated in the progression of inflammatory bowel disease (IBD) and intestinal barrier dysfunction. The polyphenolic compound, geraniin, possesses bioactive properties, such as antitumor, antioxidant, anti-inflammatory, antihypertensive, and antiviral activities; however, its IL-1β-targeted anticolitis activity remains unclear. Here, we evaluated the inhibitory effect of geraniin in IL-1β-stimulated Caco-2 cells and a dextran sulfate sodium (DSS)-induced colitis mouse model...
March 26, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38530591/glutamine-mediated-modulation-of-xo-uric-acid-nf-kb-signaling-pathway-ameliorates-intestinal-i-r-induced-bacterial-translocation-and-cardiorenal-inflammatory-injury
#34
JOURNAL ARTICLE
Moses Agbomhere Hamed, Oyedele Oladipo Adegboyega, Olalekan Isreal Ojo, Tunmise Maryanne Akhigbe, Folakemi Dorcas Fajuyitan, Omolade Christianah Adeyemo, Tomisin Folashade Odebunmi, Oluwapelumi Sarah Adeniyi, Isaac Ayomide Omole, Roland Eghoghosoa Akhigbe
This study explored the effect of intestinal ischaemia/reperfusion (I/R) on cardiorenal tissues. The involvement of xanthine oxidase/uric acid/NF-kB signaling in intestinal I/R was also investigated. In addition, the possible protective effect of glutamine was also evaluated. Twenty-four male Wistar rats were acclimatized and then randomly assigned to four groups (n = 6); sham-operated, glutamine-treated rats (GLUT), I/R, and I/R + GLUT. The sham-operated rats were sham-operated and received 0.5 mL of distilled water, GLUT rats were sham-operated and had 1 g/kg b...
March 26, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38530256/tolerogenic-cd11c-dendritic-cells-regulate-cd4-tregs-in-replacing-delayed-ischemic-preconditioning-to-alleviate-ischemia-reperfusion-acute-kidney-injury
#35
JOURNAL ARTICLE
Pingping Wang, Chunyao Li, Tao Peng, Longzhu Ruan, Aijie Wu, Jiaojiao Zhu, Wenlu Shi, Menghua Chen, Ting Zhang
Ischemia-reperfusion injury (IRI) is one of the primary clinical causes of acute kidney injury (AKI). The key to IRI lies in immune-inflammatory damage, where dendritic cells (DCs) play a central role in eliciting immune responses within the context of inflammation induced by ischemia-reperfusion. Our previous study has confirmed that delayed ischemic preconditioning (DIPC) can reduce the kidney injury by mediating DCs to regulate T-cells. However, the clinical feasibility of DIPC is limited, as pre-clamping of the renal artery is not applicable for the prevention and treatment of ischemia-reperfusion acute kidney injury (I/R-AKI) in clinical patients...
March 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38530032/ifn-%C3%AE-drives-distinct-lung-immune-landscape-changes-and-antiviral-responses-in-human-metapneumovirus-infection
#36
JOURNAL ARTICLE
Jorna Sojati, Olivia B Parks, Yu Zhang, Sara Walters, Jie Lan, Taylor Eddens, Dequan Lou, Li Fan, Kong Chen, Tim D Oury, John V Williams
UNLABELLED: Human metapneumovirus (HMPV) is a primary cause of acute respiratory infection, yet there are no approved vaccines or antiviral therapies for HMPV. Early host responses to HMPV are poorly characterized, and further understanding could identify important antiviral pathways. Type III interferon (IFN-λ) displays potent antiviral activity against respiratory viruses and is being investigated for therapeutic use. However, its role in HMPV infection remains largely unknown...
March 26, 2024: MBio
https://read.qxmd.com/read/38529489/ehmt2-inactivation-in-pancreatic-epithelial-cells-shapes-the-transcriptional-landscape-and-inflammation-response-of-the-whole-pancreas
#37
Gareth Pollin, Angela J Mathison, Thiago M de Assuncao, Anju Thomas, Lida Zeighami, Ann Salmonson, Hongfei Liu, Guillermo Urrutia, Pallavi Vankayala, Stephen J Pandol, Michael T Zimmermann, Juan Iovanna, Victor X Jin, Raul Urrutia, Gwen Lomberk
The Euchromatic Histone Methyl Transferase Protein 2 (EHMT2), also known as G9a, deposits transcriptionally repressive chromatin marks that play pivotal roles in the maturation and homeostasis of multiple organs. Recently, we have shown that EHMT2 inactivation alters growth and immune gene expression networks, antagonizing KRAS-mediated pancreatic cancer initiation and promotion. Here, we elucidate the essential role of EHMT2 in maintaining a transcriptional landscape that protects organs from inflammation...
March 16, 2024: bioRxiv
https://read.qxmd.com/read/38529288/comprehensive-analysis-of-lung-macrophages-and-dendritic-cells-in-two-murine-models-of-allergic-airway-inflammation-reveals-model-and-subset-specific-accumulation-and-phenotypic-alterations
#38
JOURNAL ARTICLE
Belinda Camp, Ilka Jorde, Franka Sittel, Alexander Pausder, Andreas Jeron, Dunja Bruder, Jens Schreiber, Sabine Stegemann-Koniszewski
INTRODUCTION: Allergic asthma has been mainly attributed to T helper type 2 (Th2) and proinflammatory responses but many cellular processes remain elusive. There is increasing evidence for distinct roles for macrophage and dendritic cell (DC) subsets in allergic airway inflammation (AAI). At the same time, there are various mouse models for allergic asthma that have been of utmost importance in identifying key inflammatory pathways in AAI but that differ in the allergen and/or route of sensitization...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38528832/role-of-dendritic-cells-in-spinal-cord-injury
#39
REVIEW
Xiaonan Han, Mingkang Zhang, Liyan Yan, Yikun Fu, Hongwei Kou, Chunfeng Shang, Junmin Wang, Hongjian Liu, Chao Jiang, Jian Wang, Tian Cheng
BACKGROUND: Inflammation can worsen spinal cord injury (SCI), with dendritic cells (DCs) playing a crucial role in the inflammatory response. They mediate T lymphocyte differentiation, activate microglia, and release cytokines like NT-3. Moreover, DCs can promote neural stem cell survival and guide them toward neuron differentiation, positively impacting SCI outcomes. OBJECTIVE: This review aims to summarize the role of DCs in SCI-related inflammation and identify potential therapeutic targets for treating SCI...
March 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38528729/indole-3-acetic-acid-alleviates-dss-induced-colitis-by-promoting-the-production-of-r-equol-from-bifidobacterium-pseudolongum
#40
JOURNAL ARTICLE
Miaomiao Li, Xue Han, Lijun Sun, Xinjuan Liu, Weizhen Zhang, Jianyu Hao
BACKGROUND: Inflammatory bowel disease (IBD) is characterized by immune-mediated, chronic inflammation of the intestinal tract. The occurrence of IBD is driven by the complex interactions of multiple factors. The objective of this study was to evaluate the therapeutic effects of IAA in colitis. METHOD: C57/BL6 mice were administered 2.5% DSS in drinking water to induce colitis. IAA, Bifidobacterium pseudolongum, and R-equol were administered by oral gavage and fed a regular diet...
2024: Gut Microbes
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