keyword
https://read.qxmd.com/read/38532785/nebulization-of-low-dose-aspirin-ameliorates-huntington-s-pathology-in-n171-82q-transgenic-mice
#21
JOURNAL ARTICLE
Susanta Mondal, Shelby Prieto, Suresh B Rangasamy, Debashis Dutta, Kalipada Pahan
Huntington Disease (HD), a devastating hereditary neurodegenerative disorder, is caused by expanded CAG trinucleotide repeats in the huntingtin gene ( Htt ) on chromosome 4. Currently, there is no effective therapy for HD. Although aspirin, acetylsalicylic acid, is one of the most widely-used analgesics throughout the world, it has some side effects. Even at low doses, oral aspirin can cause gastrointestinal symptoms, such as heartburn, upset stomach, or pain. Therefore, to bypass the direct exposure of aspirin to stomach, here, we described a new mode of use of aspirin and demonstrated that nebulization of low-dose of aspirin (10 μg/mouse/d=0...
March 2024: NeuroImmune Pharm Ther
https://read.qxmd.com/read/38532634/ampk-activation-modulates-il-36-induced-inflammatory-responses-by-regulating-i%C3%AE%C2%BAb%C3%AE-expression-in-the-skin
#22
JOURNAL ARTICLE
Yi-Ting Huang, Ling-Ya Chiu, Po-Hsuan Lu, Pa-Fan Hsiao, Jen-Yu Wang, Ping-Hsun Lu, Nan-Lin Wu
BACKGROUND AND PURPOSE: The interleukin (IL)-36 pathway is a critical player in the pathogenesis of pustular psoriasis. However, therapies targeting this pathway are limited or unaffordable (e.g. the anti-IL-36 receptor antibody). AMP-activated protein kinase (AMPK), a regulator of cellular energy and metabolism, is known to participate in inflammatory diseases. However, its role in IL-36-induced skin inflammation remains unclear. Therefore, we sought to investigate the role of AMPK signals in regulating IL-36-induced responses in the skin...
March 26, 2024: British Journal of Pharmacology
https://read.qxmd.com/read/38532628/in-vitro-and-in-vivo-validation-of-the-antiviral-effect-of-hcypa-against-sars-cov-2-via-binding-to-the-rbd-of-spike-protein
#23
JOURNAL ARTICLE
Woo-Ri Shin, Do-Young Kim, Sang Yong Kim, Gna Ahn, Dae-Young Park, Jiho Min, Ji-Young Ahn, Yang-Hoon Kim
The novel coronavirus disease 2019 has stimulated the rapid development of new biological therapeutics to inhibit SARS-CoV-2 infection; however, this remains a challenging task. In a previous study using structural analysis, we revealed that human cyclophilin A inhibits the entry of SARS-CoV-2 into host cells by interfering with the interaction of the receptor-binding domain of the spike protein with angiotensin-converting enzyme 2 on the host cell surface, highlighting its potential for antiviral therapy. For a comprehensive experimental validation, in this study, we verified the antiviral effects of human cyclophilin A against SARS-CoV-2, including its variants, using in vitro assays and experiments on an in vivo mouse model...
March 25, 2024: Molecular Therapy
https://read.qxmd.com/read/38532578/biological-agent-exerts-therapeutic-effects-by-reversing-abnormalities-in-amino-acid-metabolic-pathways-in-psoriasis
#24
JOURNAL ARTICLE
Haijun Miao, Yaxing Bai, Shengxian Shen, Mengyang Chu, Chang Miao, Jundan Yang, Xia Li, Liang Li, Shuai Shao, Gang Wang, Erle Dang
Psoriasis is a common chronic inflammatory skin disease with a complex pathogenesis involving immune system dysregulation and inflammation. Previous studies have indicated that metabolic abnormalities are closely related to the development and occurrence of psoriasis. However, the specific involvement of amino acid metabolism in the pathogenesis of psoriasis remains unclear. In this study, we conducted a comprehensive analysis of amino acid metabolism pathway changes in psoriasis patients using transcriptome data, genome-wide association studies (GWASs) data, and single-cell data...
March 2024: Experimental Dermatology
https://read.qxmd.com/read/38532515/inflammation-and-acute-cardiotoxicity-in-adult-hematological-patients-treated-with-car-t-cells-results-from-a-pilot-proof-of-concept-study
#25
JOURNAL ARTICLE
Massimiliano Camilli, Marcello Viscovo, Tamara Felici, Luca Maggio, Federico Ballacci, Giacomo Carella, Alice Bonanni, Priscilla Lamendola, Lorenzo Tinti, Antonio Di Renzo, Giulia Coarelli, Eugenio Galli, Giovanna Liuzzo, Francesco Burzotta, Rocco Antonio Montone, Federica Sorà, Simona Sica, Stefan Hohaus, Gaetano Antonio Lanza, Filippo Crea, Antonella Lombardo, Giorgio Minotti
AIMS: Chimeric Antigen Receptor-T (CAR-T) cell infusion is a rapidly evolving antitumor therapy; however, cardiovascular (CV) complications, likely associated with cytokine release syndrome (CRS) and systemic inflammation, have been reported to occur. The CARdio-Tox study aimed at elucidating incidence and determinants of cardiotoxicity related to CAR-T cell therapy. METHODS: Patients with blood malignancies candidate to CAR-T cells were prospectively evaluated by echocardiography at baseline and 7 and 30 days after infusion...
March 27, 2024: Cardio-Oncology
https://read.qxmd.com/read/38532447/peptidoglycan-in-osteoarthritis-synovial-tissue-is-associated-with-joint-inflammation
#26
JOURNAL ARTICLE
Meaghan N Holub, Amanda Wahhab, Joseph R Rouse, Rebecca Danner, Lauren G Hackner, Christine B Duris, Mecaila E McClune, Jules M Dressler, Klemen Strle, Brandon L Jutras, Adam I Edelstein, Robert B Lochhead
OBJECTIVES: Peptidoglycan (PG) is an arthritogenic bacterial cell wall component whose role in human osteoarthritis is poorly understood. The purpose of this study was to determine if PG is present in synovial tissue of osteoarthritis patients at the time of primary total knee arthroplasty (TKA), and if its presence is associated with inflammation and patient reported outcomes. METHODS: Intraoperative synovial tissue and synovial fluid samples were obtained from 56 patients undergoing primary TKA, none of whom had history of infection...
March 27, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38532383/single-cell-rna-sequencing-reveals-the-immune-features-and-viral-tropism-in-the-central-nervous-system-of-mice-infected-with-japanese-encephalitis-virus
#27
JOURNAL ARTICLE
Ling'en Yang, Junyao Xiong, Yixin Liu, Yinguang Liu, Xugang Wang, Youhui Si, Bibo Zhu, Huanchun Chen, Shengbo Cao, Jing Ye
Japanese encephalitis virus (JEV) is a neurotropic pathogen that causes lethal encephalitis. The high susceptibility and massive proliferation of JEV in neurons lead to extensive neuronal damage and inflammation within the central nervous system. Despite extensive research on JEV pathogenesis, the effect of JEV on the cellular composition and viral tropism towards distinct neuronal subtypes in the brain is still not well comprehended. To address these issues, we performed single-cell RNA sequencing (scRNA-seq) on cells isolated from the JEV-highly infected regions of mouse brain...
March 26, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38532310/patients-with-chronic-hepatitis-b-who-have-persistently-normal-alanine-aminotransferase-or-aged%C3%A2-%C3%A2-30%C3%A2-years-may-exhibit-significant-histologic-damage
#28
JOURNAL ARTICLE
Sufang Wei, Qiuli Xie, Guichan Liao, Hongjie Chen, Meixin Hu, Xiaoli Lin, Hong Li, Jie Peng
BACKGROUND: The timing of antiviral therapy for chronic hepatitis B (CHB) patients with normal alanine transaminase (ALT) or aged < 30 years is still undetermined. We aimed to elucidate the correlation between liver histology, age, and ALT level in CHB patients and analyze the histological characteristics of the liver among patients with persistently normal ALT or aged < 30 years. METHODS: A retrospective analysis was conducted on 697 treatment-naive CHB patients...
March 27, 2024: BMC Gastroenterology
https://read.qxmd.com/read/38532017/a-cd25-biased-interleukin-2-for-autoimmune-therapy-engineered-via-a-semi-synthetic-organism
#29
JOURNAL ARTICLE
Jerod L Ptacin, Lina Ma, Carolina E Caffaro, Nicole V Acuff, Kristine Germar, Peter Severy, Yanyan Qu, Jose-Luis Vela, Xinming Cai, Kristine M San Jose, Hans R Aerni, David B Chen, Ean Esche, Taylor K Ismaili, Rob Herman, Yelena Pavlova, Michael J Pena, Jasmine Nguyen, Lilia K Koriazova, Laura K Shawver, Ingrid B Joseph, Jill Mooney, Mark Peakman, Marcos E Milla
BACKGROUND: Natural cytokines are poorly suited as therapeutics for systemic administration due to suboptimal pharmacological and pharmacokinetic (PK) properties. Recombinant human interleukin-2 (rhIL-2) has shown promise for treatment of autoimmune (AI) disorders yet exhibits short systemic half-life and opposing immune responses that negate an appropriate therapeutic index. METHODS: A semi-synthetic microbial technology platform was used to engineer a site-specifically pegylated form of rhIL-2 with enhanced PK, specificity for induction of immune-suppressive regulatory CD4 + T cells (Tregs), and reduced stimulation of off-target effector T and NK cells...
March 26, 2024: Commun Med (Lond)
https://read.qxmd.com/read/38531564/investigation-of-renal-perfusion-and-pathological-changes-in-patients-with-acute-kidney-disease-and-tubulointerstitial-nephritis-using-intravoxel-incoherent-motion-and-arterial-spin-labelling-mri-a-prospective-observational-study-protocol
#30
JOURNAL ARTICLE
Jiajia Liu, Rui Wang, Jianxing Qiu, Tao Su
INTRODUCTION: Acute kidney injury (AKI) is a critical condition with a complex aetiology and different outcomes, where haemodynamic dysfunction, renal hypoperfusion and inflammation serve as key contributors to its development and progression. Early and accurate diagnosis is vital for initiating targeted treatments like fluid resuscitation, vasoactive agents or steroid therapy, which are essential for improving patient outcomes. Intravoxel incoherent motion (IVIM) MRI assesses both capillary perfusion and tissue water diffusion, while arterial spin labelling (ASL) MRI measures renal blood flow without the need for contrast...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531361/twin-study-dissects-cxcr3-memory-b-cells-as-non-heritable-feature-in-multiple-sclerosis
#31
JOURNAL ARTICLE
Florian Ingelfinger, Kirsten L Kuiper, Can Ulutekin, Lukas Rindlisbacher, Sarah Mundt, Lisa Ann Gerdes, Joost Smolders, Marvin M van Luijn, Burkhard Becher
BACKGROUND: In multiple sclerosis (MS), B cells are considered main triggers of the disease, likely as the result of complex interaction between genetic and environmental risk factors. Studies on monozygotic twins discordant for MS offer a unique way to reduce this complexity and reveal discrepant subsets. METHODS: In this study, we analyzed B cell subsets in blood samples of monozygotic twins with and without MS using publicly available data. We verified functional characteristics by exploring the role of therapy and performed separate analyses in unrelated individuals...
March 18, 2024: Med
https://read.qxmd.com/read/38530106/antineoplastics-for-treating-alzheimer-s-disease-and-dementia-evidence-from-preclinical-and-observational-studies
#32
REVIEW
Viswanath Das, John H Miller, Charanraj Goud Alladi, Narendran Annadurai, Juan Bautista De Sanctis, Lenka Hrubá, Marián Hajdúch
As the world population ages, there will be an increasing need for effective therapies for aging-associated neurodegenerative disorders, which remain untreatable. Dementia due to Alzheimer's disease (AD) is one of the leading neurological diseases in the aging population. Current therapeutic approaches to treat this disorder are solely symptomatic, making the need for new molecular entities acting on the causes of the disease extremely urgent. One of the potential solutions is to use compounds that are already in the market...
March 26, 2024: Medicinal Research Reviews
https://read.qxmd.com/read/38530032/ifn-%C3%AE-drives-distinct-lung-immune-landscape-changes-and-antiviral-responses-in-human-metapneumovirus-infection
#33
JOURNAL ARTICLE
Jorna Sojati, Olivia B Parks, Yu Zhang, Sara Walters, Jie Lan, Taylor Eddens, Dequan Lou, Li Fan, Kong Chen, Tim D Oury, John V Williams
UNLABELLED: Human metapneumovirus (HMPV) is a primary cause of acute respiratory infection, yet there are no approved vaccines or antiviral therapies for HMPV. Early host responses to HMPV are poorly characterized, and further understanding could identify important antiviral pathways. Type III interferon (IFN-λ) displays potent antiviral activity against respiratory viruses and is being investigated for therapeutic use. However, its role in HMPV infection remains largely unknown...
March 26, 2024: MBio
https://read.qxmd.com/read/38529957/pan-enteric-capsule-endoscopy-to-characterize-crohn-s-disease-phenotypes-and-predict-clinical-outcomes-in-children-and-adults-the-bomiro-study
#34
JOURNAL ARTICLE
Salvatore Oliva, Silvio Veraldi, Giusy Russo, Marina Aloi, Fernando Rizzello, Paolo Gionchetti, Patrizia Alvisi, Flavio Labriola, Maurizio Vecchi, Pini Eidler, Luca Elli, Nikolas Dussias, Gian Eugenio Tontini, Carlo Calabrese
BACKGROUND: Pan-enteric capsule endoscopy (PCE) provides useful information for the management of Crohn's disease (CD), especially in children. No study has evaluated the ability of PCE to characterize CD phenotypes and outcomes in children and adults. METHODS: In a prospective multicenter observational study, we recruited patients with CD >6 years from 4 centers in Italy. Patients underwent clinical, biomarker assessment and PCE. Lesions were graded using the PCE system...
March 26, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38529872/-neuropathy-in-n-hexane-poisoning
#35
JOURNAL ARTICLE
E S Druzhinina, A A Kozyreva, R T Bembeeva, A S Kozlovsky, V E Sokolova, I V Isaev, A G Narbutov, N N Zavadenko, O A Tikhonova
N-Hexane is a solvent widely used in manufacturing as a cleaner, degreaser and component of rubber cement. Chronic exposure to n -hexane either through contact with unprotected skin or inhalation can lead to the development of clinical symptoms and electrophysiological changes similar to those of inflammatory demyelinating polyneuropathy which requires careful differential diagnosis. This article presents three cases of severe predominantly motor polyneuropathy with demyelinating features in 15- and 16-year-old adolescents...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/38529605/role-of-abca1-in-atherosclerosis-novel-mutations-and-potential-plant-derived-therapies
#36
JOURNAL ARTICLE
Siarhei A Dabravolski, Nikolay A Orekhov, Victor Y Glanz, Vasily N Sukhorukov, Elizaveta M Pleshko, Alexander N Orekhov
ATP-binding cassette transporter A1 (ABCA1) is one of the key proteins regulating cholesterol homeostasis and playing a crucial role in atherosclerosis development. ABCA1 regulates the rate-limiting step of reverse cholesterol transport, facilitates the efflux of surplus intracellular cholesterol and phospholipids, and suppresses inflammation through several signalling pathways. At the same time, many mutations and Single Nucleotide Polymorphisms (SNPs) have been identified in the ABCA1 gene, which affects its biological function and is associated with several hereditary diseases (such as familial hypo-alpha-lipoproteinaemia and Tangier disease) and increased risk of cardiovascular diseases (CVDs)...
March 25, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38529299/effect-of-anti-inflammatory-treatments-on-patient-outcomes-and-concentrations-of-inflammatory-modulators-in-the-post-surgical-and-post-traumatic-tibiofemoral-joint-setting-a-narrative-review
#37
REVIEW
Conner P Olson, Mitchell I Kennedy, Nicholas N DePhillipo, Adam J Tagliero, Robert F LaPrade, Nicholas I Kennedy
BACKGROUND AND OBJECTIVE: There are several anti-inflammatory therapeutic options that can be used in the context of post-surgical and post-traumatic knee settings. Each of these options carries with it certain benefits, as well as potential issues depending on the duration and administration of each therapy. An understanding of how these anti-inflammatory drugs modulate various biomarkers of inflammation is also necessary in understanding how they can affect patient and objective outcomes following acute knee injury or surgery...
2024: Annals of joint
https://read.qxmd.com/read/38529284/oxidative-phosphorylation-in-hiv-1-infection-impacts-on-cellular-metabolism-and-immune-function
#38
REVIEW
Natalia Rodriguez Rodriguez, Trinisia Fortune, Esha Hegde, Matthew Paltiel Weinstein, Aislinn M Keane, Jesse F Mangold, Talia H Swartz
Human Immunodeficiency Virus Type 1 (HIV-1) presents significant challenges to the immune system, predominantly characterized by CD4+ T cell depletion, leading to Acquired Immunodeficiency Syndrome (AIDS). Antiretroviral therapy (ART) effectively suppresses the viral load in people with HIV (PWH), leading to a state of chronic infection that is associated with inflammation. This review explores the complex relationship between oxidative phosphorylation, a crucial metabolic pathway for cellular energy production, and HIV-1, emphasizing the dual impact of HIV-1 infection and the metabolic and mitochondrial effects of ART...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38529271/the-role-of-immune-cells-and-inflammation-in-pulmonary-hypertension-mechanisms-and-implications
#39
REVIEW
Hui Zhao, Jialin Song, Xiujun Li, Zhaoyi Xia, Qian Wang, Jiaqi Fu, Yuqing Miao, Dapeng Wang, Xuguang Wang
Pulmonary hypertension (PH) is a malignant disease with progressive increase of pulmonary vascular pressure, which eventually leads to right heart failure. More and more evidences show that immune cells and inflammation play an important role in the occurrence and development of PH. In the context of pulmonary vascular diseases, immune cells migrate into the walls of the pulmonary vascular system. This leads to an increase in the levels of cytokines and chemokines in both the bloodstream and the surrounding tissues of the pulmonary vessels...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38529115/recent-advances-in-the-therapeutic-management-of-calcium-pyrophosphate-deposition-disease
#40
REVIEW
Paraskevi V Voulgari, Aliki I Venetsanopoulou, Alexandros A Drosos
Calcium pyrophosphate deposition (CPPD) disease is a form of crystal-induced arthropathy that arises from the accumulation of calcium pyrophosphate crystals within joints and soft tissues. This process leads to inflammation and damage to the affected joints. It can present asymptomatically or as acute or chronic inflammatory arthritis. Risk factors and comorbidities, including prior joint injury, osteoarthritis, hereditary or familial predisposition, and metabolic diseases, should be evaluated in CPPD cases...
2024: Frontiers in Medicine
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