Montana Kay Lara, Apurva S Chitre, Denghui Chen, Benjamin B Johnson, Khai-Minh Nguyen, Katarina A Cohen, Sakina A Muckadam, Bonnie Lin, Shae Ziegler, Angela Beeson, Thiago Sanches, Leah C Solberg Woods, Oksana Polesskaya, Abraham A Palmer, Suzanne H Mitchell
Delay discounting refers to the behavioral tendency to devalue rewards as a function of their delay in receipt. Heightened delay discounting has been associated with substance use disorders, as well as multiple co-occurring psychopathologies. Genetic studies in humans and animal models have established that delay discounting is a heritable trait, but only a few specific genes have been associated with delay discounting. Here, we aimed to identify novel genetic loci associated with delay discounting through a genome-wide association study (GWAS) using Heterogenous Stock rats, a genetically diverse outbred population derived from eight inbred founder strains...
December 13, 2023: bioRxiv