keyword
MENU ▼
Read by QxMD icon Read
search

Sucrose reward

keyword
https://www.readbyqxmd.com/read/29214467/different-functional-domains-measured-by-cocaine-self-administration-under-the-progressive-ratio-and-punishment-schedules-in-male-wistar-rats
#1
Udita Datta, Mariangela Martini, WenLin Sun
BACKGROUND: Current diagnosis of drug addiction like other mental disorders is based on clinical symptoms not on neural pathophysiology and consequently, does not provide useful information on the underlying pathophysiology and may impede the efforts to identify the underlying mechanisms. Identifying the functional deficits that are relevant to addiction and can be traced to the neural systems will greatly facilitate our understanding of the heterogeneity of the condition and improve future diagnosis and treatment...
December 6, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29197982/dissociation-of-place-preference-and-tolerance-responses-to-sucrose-using-a-dopamine-antagonist-in-the-planarian
#2
Rafat A Mohammed Jawad, Claire V Hutchinson, Jose Prados
In rodents, sucrose has been found to elicit addictive-like behaviours like the development of tolerance and the association with cues present at the time of consumption. Furthermore, the neurochemical response to sucrose binges is equivalent to the one observed in response to the abuse of addictive substances like cocaine. The experiments reported here address the effects of sucrose on an invertebrate model, the Platyhelminth brown planarian. The animals exposed to a 10% sucrose solution in one context developed a conditioned place preference (CPP) which was subsequently extinguished in the absence of the rewarding agent...
December 2, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29175512/altering-d1-receptor-activity-in-the-basolateral-amygdala-impairs-fear-suppression-during-a-safety-cue
#3
Ka H Ng, Michael W Pollock, Phillip J Urbanczyk, Susan Sangha
Accurate discrimination among cues signifying reward, danger or safety initiates the proper emotional response in order to guide behavior. Appropriate conditioned inhibition of fear in the presence of a safety cue would allow an organism to engage in reward seeking behaviors. There is currently little known about the mechanisms of reward, fear and safety cue discrimination and how a safety cue can inhibit fear and release reward seeking from inhibition. Here we assess reward, fear and safety cue learning together using a behavioral paradigm that has identified neurons that discriminate among these cues in the basolateral amygdala (BLA) (Sangha, Chadick, & Janak, 2013)...
November 22, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29168193/the-effects-of-long-term-varenicline-administration-on-ethanol-and-sucrose-seeking-and-self-administration-in-male-p-rats
#4
Cristine L Czachowski, Janice C Froehlich, Michael DeLory
BACKGROUND: Varenicline, a partial agonist at α4β2 and full agonist at α7 nicotinic cholinergic receptors, is FDA approved for treatment of smoking cessation and has been found to reduce alcohol craving in clinical populations. In rodents, varenicline decreases free-choice ethanol intake with somewhat mixed findings in operant paradigms that utilize a combined appetitive/consummatory response. METHODS: The present experiment utilized an operant paradigm that procedurally separates appetitive from consummatory responding and a "reward blocking" approach (i...
November 23, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29153928/enhancing-excitability-of-dopamine-neurons-promotes-motivational-behaviour-through-increased-action-initiation
#5
Linde Boekhoudt, Ellen C Wijbrans, Jodie H K Man, Mieneke C M Luijendijk, Johannes W de Jong, Geoffrey van der Plasse, Louk J M J Vanderschuren, Roger A H Adan
Motivational deficits are a key symptom in multiple psychiatric disorders, including major depressive disorder, schizophrenia and addiction. A likely neural substrate for these motivational deficits is the brain dopamine (DA) system. In particular, DA signalling in the nucleus accumbens, which originates from DA neurons in the ventral tegmental area (VTA), has been identified as a crucial substrate for effort-related and activational aspects of motivation. Unravelling how VTA DA neuronal activity relates to motivational behaviours is required to understand how motivational deficits in psychiatry can be specifically targeted...
November 16, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29146502/protracted-motivational-dopamine-related-deficits-following-adolescence-sugar-overconsumption
#6
Fabien Naneix, Florence Darlot, Véronique De Smedt-Peyrusse, Jean-Rémi Pape, Etienne Coutureau, Martine Cador
Adolescence represents a critical period characterized by major neurobiological changes. Chronic stimulation of the reward system during adolescence might constitute an important factor of vulnerability to pathological development. Increasing evidences suggest that adolescent overconsumption of sweet palatable foods impact reward-based processes. However, the neurobiological bases of these deficits remain poorly understood. Previous studies have demonstrated motivational deficits for palatable foods after sweet diet exposure during adolescence that might involve the dopamine (DA) system, a central actor in incentive processes...
February 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29141007/escitalopram-and-nht-normalized-stress-induced-anhedonia-and-molecular-neuroadaptations-in-a-mouse-model-of-depression
#7
Or Burstein, Motty Franko, Eyal Gale, Assaf Handelsman, Segev Barak, Shai Motsan, Alon Shamir, Roni Toledano, Omri Simhon, Yafit Hirshler, Gang Chen, Ravid Doron
Anhedonia is defined as a diminished ability to obtain pleasure from otherwise positive stimuli. Anxiety and mood disorders have been previously associated with dysregulation of the reward system, with anhedonia as a core element of major depressive disorder (MDD). The aim of the present study was to investigate whether stress-induced anhedonia could be prevented by treatments with escitalopram or novel herbal treatment (NHT) in an animal model of depression. Unpredictable chronic mild stress (UCMS) was administered for 4 weeks on ICR outbred mice...
2017: PloS One
https://www.readbyqxmd.com/read/29127070/an-early-experience-of-mild-adversity-involving-temporary-denial-of-maternal-contact-affects-the-serotonergic-system-of-adult-male-rats-and-leads-to-a-depressive-like-phenotype-and-inability-to-adapt-to-a-chronic-social-stress
#8
Anastasia Diamantopoulou, Theodora Kalpachidou, Georgios Aspiotis, Ioannis Gampierakis, Fotini Stylianopoulou, Antonios Stamatakis
Adverse early life experiences can affect adaptability to chronic stressors and lead to depressive-like behaviors in animal models. We employed an early experience model in which rat pups during postnatal days 10-13 are exposed to a T-maze in which they learn the location of their mother motivated by the rewarding stimulus of maternal contact; one group of rats receives the expected reward, by being allowed contact with the mother upon finding her, while the other group is temporarily denied this contact (Denied Expected Reward, DER), thus experiencing mild adversity...
November 7, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29126998/high-runner-mice-have-reduced-incentive-salience-for-a-sweet-taste-reward-when-housed-with-wheel-access
#9
Zoe Thompson, Erik M Kolb, Theodore Garland
To explore reward substitution in the context of voluntary exercise, female mice from four replicate high-runner (HR) lines (bred for wheel running) and four non-selected control (C) lines were given simultaneous access to wheels and palatable solutions as competing rewards (two doses of saccharin [0.1, 0.2% w/v]; two doses of common artificial sweetener blends containing saccharin [Sweet 'N Low(®): 0.1, 0.2% w/v], aspartame [Equal(®): 0.04, 0.08% w/v], or sucralose [Splenda(®): 0.08, 0.16% w/v]; or two doses of sucrose [3...
November 7, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/29109253/a-transient-dopamine-signal-encodes-subjective-value-and-causally-influences-demand-in-an-economic-context
#10
Scott A Schelp, Katherine J Pultorak, Dylan R Rakowski, Devan M Gomez, Gregory Krzystyniak, Raibatak Das, Erik B Oleson
The mesolimbic dopamine system is strongly implicated in motivational processes. Currently accepted theories suggest that transient mesolimbic dopamine release events energize reward seeking and encode reward value. During the pursuit of reward, critical associations are formed between the reward and cues that predict its availability. Conditioned by these experiences, dopamine neurons begin to fire upon the earliest presentation of a cue, and again at the receipt of reward. The resulting dopamine concentration scales proportionally to the value of the reward...
November 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29100991/cue-induced-reinstatement-of-alcohol-seeking-behavior-is-associated-with-increased-camkii-t286-phosphorylation-in-the-reward-pathway-of-mice
#11
Michael C Salling, Christopher J Hodge, Kelly E Psilos, Vallari R Eastman, Sara P Faccidomo, Clyde W Hodge
Cue-induced reinstatement of alcohol-seeking is a hallmark behavioral pathology of addiction. Evidence suggests that reinstatement (e.g., relapse), may be regulated by cell signaling systems that underlie neuroplasticity. A variety of plasticity events require activation of calcium calmodulin-dependent protein kinase II (CaMKII) in components of the reward pathway, such as the nucleus accumbens and amygdala. We sought to determine if cue-induced reinstatement of alcohol-seeking behavior is associated with changes in the activation state (e...
October 31, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29100151/aripiprazole-relieves-motivational-anhedonia-in-rats
#12
Simona Scheggi, Teresa Pelliccia, Carla Gambarana, Maria Graziella De Montis
BACKGROUND: Anhedonia is considered a relevant feature in depression and psychosis, characterized by poor treatment outcome, and associated with deficits in mesolimbic dopaminergic responsiveness. Clinical studies suggest the potential utility of aripiprazole as adjunctive therapy for resistant depression. Since aripiprazole can stabilize the dopaminergic system, in search of tailored therapeutic strategies for reward dysfunctions, we investigated whether the drug restored motivation toward positive stimuli in a rat model...
October 20, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29075568/divergent-anomaly-in-mesocorticolimbic-dopaminergic-circuits-might-be-associated-with-different-depressive-behaviors-an-animal-study
#13
Mei Bai, Xiongzhao Zhu, Li Zhang, Yi Zhang, Liang Xue, Yuting Wang, Mingtian Zhong, Xiuwu Zhang
BACKGROUND: The mesocorticolimbic dopamine system, which originates from the ventral tegmental area (VTA) and projects primarily to the prefrontal cortex (PFC), olfactory tubercle (OT), nucleus accumbens (NAc), dorsal striatum (ST), and the amygdala (AMy), plays a pivotal role in determining individual motivation and sensitivity to rewards, namely, anhedonia. Not all depressive individuals exhibited anhedonia, thus, it is natural to speculate that the heterogenous manifestations of depression might be related to the mesocorticolimbic dopamine system...
October 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29073109/opioid-and-orexin-hedonic-hotspots-in-rat-orbitofrontal-cortex-and-insula
#14
Daniel C Castro, Kent C Berridge
Hedonic hotspots are brain sites where particular neurochemical stimulations causally amplify the hedonic impact of sensory rewards, such as "liking" for sweetness. Here, we report the mapping of two hedonic hotspots in cortex, where mu opioid or orexin stimulations enhance the hedonic impact of sucrose taste. One hedonic hotspot was found in anterior orbitofrontal cortex (OFC), and another was found in posterior insula. A suppressive hedonic coldspot was also found in the form of an intervening strip stretching from the posterior OFC through the anterior and middle insula, bracketed by the two cortical hotspots...
October 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29056427/consequences-of-continuous-social-defeat-stress-on-anxiety-and-depressive-like-behaviors-and-ethanol-reward-in-mice
#15
Giovana Camila de Macedo, Gleice Midori Morita, Liz Paola Domingues, Cristiane Favoretto, Deborah Suchecki, Isabel Marian Hartmann Quadros
This study employed the intruder-resident paradigm to evaluate the effects of continuous social defeat on depressive- and anxiety-like behaviors and the reinforcing and motivational actions of ethanol in male Swiss mice. Male Swiss mice were exposed to a 10-day social defeat protocol, while control mice cohabitated with a non-aggressive animal. Continuous defeat stress consisted of episodes of defeat, followed by 24h or 48h cohabitation with the aggressor until the following defeat. Mice were assessed for sucrose drinking (anhedonia), social investigation test, elevated plus-maze, conditioned place preference to ethanol, and locomotor response to ethanol...
October 19, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29038598/male-specific-deficits-in-natural-reward-learning-in-a-mouse-model-of-neurodevelopmental-disorders
#16
N M Grissom, S E McKee, H Schoch, N Bowman, R Havekes, W T O'Brien, E Mahrt, S Siegel, K Commons, C Portfors, T Nickl-Jockschat, T M Reyes, T Abel
Neurodevelopmental disorders, including autism spectrum disorders, are highly male biased, but the underpinnings of this are unknown. Striatal dysfunction has been strongly implicated in the pathophysiology of neurodevelopmental disorders, raising the question of whether there are sex differences in how the striatum is impacted by genetic risk factors linked to neurodevelopmental disorders. Here we report male-specific deficits in striatal function important to reward learning in a mouse model of 16p11.2 hemideletion, a genetic mutation that is strongly associated with the risk of neurodevelopmental disorders, particularly autism and attention-deficit hyperactivity disorder...
October 17, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29037599/neural-basis-of-ventromedial-hypothalamic-oxytocin-driven-decrease-in-appetite
#17
Oscar A Klockars, Joseph R Waas, Anica Klockars, Allen S Levine, Pawel K Olszewski
OBJECTIVES: Oxytocin (OT) administration in the ventromedial hypothalamic nucleus (VMH) reduces chow intake. The nature of VMH OT's anorexigenic action remains unclear. Here we provide insight into neural mechanisms underlying VMH OT-driven anorexia by (a) identifying feeding-related brain sites activated by VMH OT injection; (b) measuring VMH OT receptor (OTr) mRNA changes in response to hunger and palatability; and (c) examining how VMH OT affects episodic sweet solution intake in sated and hungry rats...
October 14, 2017: Neuroscience
https://www.readbyqxmd.com/read/29033027/anhedonia-following-early-life-adversity-involves-aberrant-interaction-of-reward-and-anxiety-circuits-and-is-reversed-by-partial-silencing-of-amygdala-corticotropin-releasing-hormone-gene
#18
Jessica L Bolton, Jenny Molet, Limor Regev, Yuncai Chen, Neggy Rismanchi, Elizabeth Haddad, Derek Z Yang, Andre Obenaus, Tallie Z Baram
BACKGROUND: Anhedonia, the diminished ability to experience pleasure, is an important dimensional entity linked to depression, schizophrenia, and other emotional disorders, but its origins and mechanisms are poorly understood. We have previously identified anhedonia, manifest as decreased sucrose preference and social play, in adolescent male rats that experienced chronic early-life adversity/stress (CES). Here we probed the molecular, cellular, and circuit processes underlying CES-induced anhedonia and tested them mechanistically...
September 7, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29022083/adolescent-cannabinoid-exposure-effects-on-natural-reward-seeking-and-learning-in-rats
#19
H Schoch, M Y Huerta, C M Ruiz, M R Farrell, K M Jung, J J Huang, R R Campbell, D Piomelli, S V Mahler
RATIONALE: Adolescence is characterized by endocannabinoid (ECB)-dependent refinement of neural circuits underlying emotion, learning, and motivation. As a result, adolescent cannabinoid receptor stimulation (ACRS) with phytocannabinoids or synthetic agonists like "Spice" cause robust and persistent changes in both behavior and circuit architecture in rodents, including in reward-related regions like medial prefrontal cortex and nucleus accumbens (NAc). OBJECTIVES AND METHODS: Here, we examine persistent effects of ACRS with the cannabinoid receptor 1/2 specific agonist WIN55-212,2 (WIN; 1...
October 11, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29021748/binge-like-sucrose-self-administration-experience-inhibits-cocaine-and-sucrose-seeking-behavior-in-offspring
#20
Qiumin Le, Yanqing Li, Weiqing Hou, Biao Yan, Xiangchen Yu, Haikun Song, Feifei Wang, Lan Ma
Recent studies show that emotional and environmental stimuli promote epigenetic inheritance and influence behavioral development in the subsequent generations. Caloric mal- and under-nutrition has been shown to cause metabolic disturbances in the subsequent generation, but the incentive properties of paternal binge-like eating in offspring is still unknown. Here we show that paternal sucrose self-administration experience could induce inter-generational decrease in both sucrose and cocaine-seeking behavior, and sucrose responding in F1 rats, but not F2, correlated with the performance of F0 rats in sucrose self-administration...
2017: Frontiers in Behavioral Neuroscience
keyword
keyword
52057
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"