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https://www.readbyqxmd.com/read/28427597/intentional-percutaneous-laceration-of%C3%A2-the%C3%A2-anterior-mitral-leaflet-to-prevent%C3%A2-outflow%C3%A2-obstruction-during-transcatheter-mitral-valve-replacement-first-in-human%C3%A2-experience
#1
Vasilis C Babaliaros, Adam B Greenbaum, Jaffar M Khan, Toby Rogers, Dee Dee Wang, Marvin H Eng, William W O'Neill, Gaetano Paone, Vinod H Thourani, Stamatios Lerakis, Dennis W Kim, Marcus Y Chen, Robert J Lederman
OBJECTIVES: This study sought to use a new catheter technique to split the anterior mitral valve leaflet (AML) and prevent iatrogenic left ventricular outflow tract (LVOT) obstruction immediately before transcatheter mitral valve replacement (TMVR). BACKGROUND: LVOT obstruction is a life-threatening complication of TMVR, caused by septal displacement of the AML. METHODS: The procedure was used in patients with severe mitral valve disease and prohibitive surgical risk...
April 24, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28396198/left-ventricular-access-point-determination-for-a-coaxial-approach-to-the-mitral-annular-landing-zone-in-transcatheter-mitral-valve-replacement
#2
Philipp Blanke, Jong K Park, Paul Grayburn, Christopher Naoum, Kevin Ong, Keshav Kohli, Bjarne L Norgaard, John G Webb, Jeffrey Popma, David Boshell, Paul Sorajja, David Muller, Jonathon Leipsic
INTRODUCTION: To facilitate coaxial device deployment in transcatheter mitral valve replacement (TMVR), a coaxial approach to the mitral annular plane is needed. We sought to establish a method to determine an 'orthogonal' left ventricular (LV) access point for transapical TMVR and to quantitatively characterize its location in patients with severe mitral regurgitation using cardiac computed tomography. METHODS: Cardiac CT data sets of 54 patients with moderate-severe mitral regurgitation evaluated for potential TMVR were analyzed...
April 7, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28370526/predictors-for-long-term-survival-after-transcatheter-edge-to-edge-mitral-valve-repair
#3
Mathias Orban, Martin Orban, Hasema Lesevic, Daniel Braun, Simon Deseive, Carolin Sonne, Lisa Hutterer, Christian Grebmer, Alexander Khandoga, Jürgen Pache, Julinda Mehilli, Heribert Schunkert, Adnan Kastrati, Christian Hagl, Axel Bauer, Steffen Massberg, Peter Boekstegers, Michael Nabauer, Ilka Ott, Jörg Hausleiter
OBJECTIVES: To determine predictors for long-term outcome in high-risk patients undergoing transcatheter edge-to-edge mitral valve repair (TMVR) for severe mitral regurgitation (MR). BACKGROUND: There is no data on predictors of long-term outcome in high-risk real-world patients. METHODS: From August 2009 to April 2011, 126 high-risk patients deemed inoperable were treated with TMVR in two high-volume university centers. RESULTS: MR could be successfully reduced to grade ≤2 in 92...
March 28, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28281857/engineering-challenges-and-the-future-prospects-of-transcatheter-mitral-valve-replacement-technologies-a-comprehensive-review-of-case-studies
#4
Ranjitha Rebecca Jeevan, Bhaskar Mohan Murari
Catheter based Interventional procedures have become an indispensable treatment option for patients contraindicated for surgical heart valve replacement . The broad spectrum of disease that affect the mitral valve have increased the need for a transcatheter mitral valve replacement (TMVR) device. As complex as the mitral valve anatomy is, so are challenges in the development of a TMVR device. Areas covered: This review article analyses the challenges in the development of the TMVR device from an engineering perspective of material and device design...
April 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28266162/short-term-results-of-alcohol-septal-ablation-as-a-bail-out-strategy-to-treat-severe-left-ventricular-outflow-tract-obstruction-after-transcatheter-mitral-valve-replacement-in-patients-with-severe-mitral-annular-calcification
#5
Mayra Guerrero, Dee Dee Wang, Dominique Himbert, Marina Urena, Amit Pursnani, Georges Kaddissi, Vijay Iyer, Michael Salinger, Tarun Chakravarty, Adam Greenbaum, Raj Makkar, Alec Vahanian, Ted Feldman, William O'Neill
OBJECTIVES: To evaluate the outcomes of the early experience of percutaneous alcohol septal ablation in patients with severe left ventricular outflow tract (LVOT) obstruction post transcatheter mitral valve replacement (TMVR). BACKGROUND: Severe LVOT obstruction with hemodynamic compromise is a complication of TMVR associated with high mortality. Percutaneous alcohol septal ablation has recently been described as a therapeutic option in this setting. METHODS: Multicenter retrospective review of clinical outcomes of patients undergoing alcohol septal ablation to treat LVOT obstruction after TMVR for severe mitral stenosis with severe mitral annular calcification...
March 7, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28222495/reversible-thrombotic-mitral-valve-stenosis-after-transcatheter-mitral-valve-replacement-tmvr-is-life-long-anticoagulation-therapy-necessary
#6
Vladan Hudec, Martin Bena, Panagiotis Artemiou, Ivo Gasparovic, Michal Hulman
We describe a case of reversible thrombotic mitral valve stenosis following a valve-in-ring transcatheter mitral valve replacement. Life-long oral anticoagulation in patients who underwent transcatheter mitral valve replacement might be beneficial.
March 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/28185392/thrombotic-valvular-dysfunction-with-transcatheter-mitral-interventions-for-postsurgical-failures
#7
Marvin H Eng, Adam Greenbaum, Dee Dee Wang, Janet Wyman, Dnp, Heider Arjomand, Pradeep Yadav, Hassan Nemeh, Gaetano Paone, Mayra Guerrero, William O'Neill
BACKGROUND: Degenerated surgical mitral valve repairs or surgical prostheses are currently being treated with transcatheter mitral valve replacement (TMVR). We report the procedural and mid-term assessment of thirteen cases. METHODS: From 12/2013 to 12/2015, 13 consecutive patients with degenerated mitral valve repair or valve replacement were treated. Patients were assessed for mitral valve academic valve consortium (MVARC) defined outcomes. RESULTS: Immediate procedural MVARC defined technical success was 92%...
February 10, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28145876/novel-use-of-mitraclip-for-severe-mitral-regurgitation-due-to-infective-endocarditis
#8
Pranav Chandrashekar, Erin A Fender, Mohammed A Al-Hijji, Krishnaswamy Chandrasekaran, Charanjit S Rihal, Mackram F Eleid, Nandan S Anavekar
A 75-year-old man presented with infective endocarditis. Transesophageal echocardiogram (TEE) revealed mild-moderate mitral regurgitation (MR). After 4 weeks of antibiotics, he presented with New York Heart Association class III dyspnea. Repeat TEE demonstrated severe MR. After consultation with Infectious Diseases, it was determined the infection risk was low and transcatheter mitral valve repair (TMVR) was offered. Deployment of two MitraClip devices (Abbott Vascular) resulted in symptom relief. This case demonstrates a potential role of TMVR in treating acute severe MR due to endocarditis...
February 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28105998/simultaneous-transfemoral-aortic-and-transseptal-mitral-valve-replacement-utilising-sapien-3-valves-in-native-aortic-and-mitral-valves
#9
Mohammad Bashir, Gardar Sigurdsson, Phillip A Horwitz, Firas Zahr
AIMS: Concomitant severe calcific aortic and mitral stenosis is a relatively uncommon but very challenging valvular heart disease to manage. We sought to evaluate the feasibility of a fully percutaneous approach to replace both stenotic native mitral and aortic valves using SAPIEN 3 valves. METHODS AND RESULTS: An 87-year-old woman with chronic kidney disease stage 3, pul-monary hypertension, chronic obstructive pulmonary disease, a permanent pacemaker, and atrial fibrillation was referred with Class III heart failure symptoms...
January 20, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28040318/transcatheter-mitral-valve-replacement-for-patients-with-symptomatic%C3%A2-mitral%C3%A2-regurgitation-a-global-feasibility-trial
#10
David W M Muller, Robert Saeid Farivar, Paul Jansz, Richard Bae, Darren Walters, Andrew Clarke, Paul A Grayburn, Robert C Stoler, Gry Dahle, Kjell A Rein, Marty Shaw, Gregory M Scalia, Mayra Guerrero, Paul Pearson, Samir Kapadia, Marc Gillinov, Augusto Pichard, Paul Corso, Jeffrey Popma, Michael Chuang, Philipp Blanke, Jonathon Leipsic, Paul Sorajja
BACKGROUND: Symptomatic mitral regurgitation (MR) is associated with high morbidity and mortality that can be ameliorated by surgical valve repair or replacement. Despite this, many patients with MR do not undergo surgery. Transcatheter mitral valve replacement (TMVR) may be an option for selected patients with severe MR. OBJECTIVES: This study aimed to examine the effectiveness and safety of TMVR in a cohort of patients with native valve MR who were at high risk for cardiac surgery...
January 31, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970202/tct-813-alcohol-septal-ablation-in-patients-with-left-ventricular-outflow-tract-obstruction-after-transcatheter-mitral-valve-replacement-for-mitral-annular-calcification-tmvr-in-mac
#11
Pradeep Yadav, Dee Dee Wang, Marvin Eng, Adam Greenbaum, William O'Neill
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27958694/transcatheter-edge-to-edge-mitral-valve-repair-in-heart-failure
#12
Mathias Orban, Martin Orban, Daniel Braun, Michael Näbauer, Steffen Massberg, Jörg Hausleiter
Heart failure and severe mitral regurgitation (MR) are mutually dependent. Secondary MR is a consequence of chronic heart failure in patients with severely depressed left ventricular ejection fraction (LV-EF) and LV dilatation. Severe MR in heart failure patients worsens prognosis and accelerates LV dilatation and decline in LV-EF. Interventional therapies have changed clinical practice for heart failure patients with secondary MR. In this review we summarize the available data of patients with chronic heart failure undergoing transcatheter edge-to-edge mitral valve repair (TMVR) with the MitraClip® system for severe secondary mitral regurgitation...
December 13, 2016: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/27923637/hypothalamic-neuronal-origin-of-neuropeptide-y-npy-or-cocaine-and-amphetamine-regulated-transcript-cart-fibers-projecting-to-the-tuberomammillary-nucleus-of-the-rat
#13
Eun Y Lee, Young G Hwang, Hyun S Lee
Based on the importance of tuberomammillary nucleus (TMN) as a target for feeding/arousal-related functions, we aimed in the present study to investigate hypothalamic neuronal origin of neuropeptide Y (NPY) and cocaine- and amphetamine-regulated transcript (CART) fibers projecting to the histaminergic nucleus. In the first series of experiments, we examined NPY (or CART) fiber distribution within the boundary of adenosine deaminase (ADA)-immunoreactive (ir) TMN regions; extensive NPY (or CART)-ir axon terminals were observed in E4 (TMMd), E3 (TMMv), and E2 (TMVr) subdivisions...
December 3, 2016: Brain Research
https://www.readbyqxmd.com/read/27861113/transcatheter-mitral-valve-replacement-a-frontier-in-cardiac-intervention
#14
REVIEW
Amar Krishnaswamy, Stephanie Mick, Jose Navia, A Marc Gillinov, E Murat Tuzcu, Samir R Kapadia
As transcatheter aortic valve replacement (TAVR) has become routine, device manufacturers and investigational cardiologists have set their sights on the mitral valve. Although transcatheter mitral valve replacement (TMVR) poses several technical challenges, they appear to be surmountable, and work is proceeding. Here we review the various devices being developed and preliminary results of trials in humans.
November 2016: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/27696544/the-learning-curve-for-transcatheter-mitral-valve-repair-with-mitraclip
#15
Mackram F Eleid, Guy S Reeder, Joseph F Malouf, Ryan J Lennon, Sorin V Pislaru, Vuyisille T Nkomo, Charanjit S Rihal
OBJECTIVES: This study sought to assess the learning curve for TMVR for treatment of primary mitral regurgitation (MR). BACKGROUND: Data are lacking regarding the technical experience required to achieve optimal clinical outcomes with transcatheter mitral valve repair (TMVR) using the edge-to-edge MitraClip technique. METHODS: We examined the sequential experience of the first 75 patients (age 80 ± 9 years; 77% male) who underwent TMVR at our institution...
October 2016: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/27640024/calcification-of-the-aortic-valve-and-mitral-apparatus-location-quantification-and-implications-for-device-selection
#16
Jonathon Leipsic, Philipp Blanke
The treatment of both aortic and now mitral valvular disease has been transformed through transcatheter valvular interventions. TAVR has rapidly become the treatment of choice for symptomatic severe aortic stenosis in both high, and now intermediate-risk patients. Building upon this success the last two years have seen the clinical introduction of transcatheter mitral valve replacement (TMVR), with a number of devices being utilised in first-in-man and feasibility studies. These experiences have helped determine the anatomical requirements and specifications that enable successful device deployment and avoidance of complications...
September 18, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27639906/sympathetic-activity-in-patients-with%C3%A2-secondary-symptomatic-mitral%C3%A2-regurgitation-or-end-stage-systolic%C3%A2-heart-failure
#17
Can Öztürk, Robert Schueler, Marcel Weber, Armin Welz, Nikos Werner, Georg Nickenig, Christoph Hammerstingl
OBJECTIVES: This study shows the impact of secondary mitral regurgitation (sMR) and transcatheter mitral valve repair (TMVR) with the MitraClip system on sympathetic nerve activity (SNA). BACKGROUND: An increase in SNA is associated with worse outcomes and limited survival in patients with chronic heart failure (CHF). METHODS: Twenty CHF-patients without relevant sMR and 30 CHF patients with symptomatic sMR were enrolled prospectively. All patients underwent standardized laboratory testing and microneurography...
October 10, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27609260/intentional-laceration-of-the-anterior-mitral-valve-leaflet-to-prevent-left-ventricular-outflow-tract-obstruction-during-transcatheter-mitral%C3%A2-valve-replacement-pre-clinical-findings
#18
Jaffar M Khan, Toby Rogers, William H Schenke, Jonathan R Mazal, Anthony Z Faranesh, Adam B Greenbaum, Vasilis C Babaliaros, Marcus Y Chen, Robert J Lederman
OBJECTIVES: The authors propose a novel transcatheter transection of the anterior mitral leaflet to prevent iatrogenic left ventricular outflow tract (LVOT) obstruction during transcatheter mitral valve replacement (TMVR). BACKGROUND: LVOT obstruction is a life-threatening complication of TMVR caused by septal displacement of the anterior mitral leaflet. METHODS: In vivo procedures in swine were guided by biplane x-ray fluoroscopy and intracardiac echocardiography...
September 12, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27388824/transcatheter-mitral-valve-replacement-in%C3%A2-native%C3%A2-mitral-valve-disease-with-severe%C3%A2-mitral%C3%A2-annular-calcification-results-from-the-first-multicenter-global-registry
#19
Mayra Guerrero, Danny Dvir, Dominique Himbert, Marina Urena, Mackram Eleid, Dee Dee Wang, Adam Greenbaum, Vaikom S Mahadevan, David Holzhey, Daniel O'Hair, Nicolas Dumonteil, Josep Rodés-Cabau, Nicolo Piazza, Jose H Palma, Augustin DeLago, Enrico Ferrari, Adam Witkowski, Olaf Wendler, Ran Kornowski, Pedro Martinez-Clark, Daniel Ciaburri, Richard Shemin, Sami Alnasser, David McAllister, Martin Bena, Faraz Kerendi, Gregory Pavlides, Jose J Sobrinho, Guilherme F Attizzani, Isaac George, George Nickenig, Amir-Ali Fassa, Alain Cribier, Vinnie Bapat, Ted Feldman, Charanjit Rihal, Alec Vahanian, John Webb, William O'Neill
OBJECTIVES: This study sought to evaluate the outcomes of the early experience of transcatheter mitral valve replacement (TMVR) with balloon-expandable valves in patients with severe mitral annular calcification (MAC) and reports the first large series from a multicenter global registry. BACKGROUND: The risk of surgical mitral valve replacement in patients with severe MAC is high. There are isolated reports of successful TMVR with balloon-expandable valves in this patient population...
July 11, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27354344/a-simplified-and-reproducible-method-to-size-the-mitral-annulus-implications-for-transcatheter-mitral-valve-replacement
#20
Mohammad Abdelghani, Ernest Spitzer, Osama I I Soliman, Dietrich Beitzke, Roberta Laggner, Rafael Cavalcante, Hiroki Tateishi, Carlos M Campos, Luc Verstraeten, Yohei Sotomi, Erhan Tenekecioglu, Yoshinobu Onuma, Jan G Tijssen, Robbert J de Winter, Francesco Maisano, Patrick W Serruys
AIMS: Transcatheter mitral valve replacement (TMVR) provides definitive valve replacement through a minimally invasive procedure. In the setting of TMVR, it remains unclear how relevant the differences between different mitral annular (MA) diameters are. We sought to define a simplified and reproducible method to describe the MA size. METHODS AND RESULTS: Using cardiac computed tomography angiography (CTA) studies of 47 patients, 3D MA perimeter (P3D) was annotated...
June 26, 2016: European Heart Journal Cardiovascular Imaging
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