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https://www.readbyqxmd.com/read/29747948/automated-quantification-of-mitral-valve-geometry-on-multi-slice-computed-tomography-in-patients-with-dilated-cardiomyopathy-implications-for-transcatheter-mitral-valve-replacement
#1
Tom Banks, Orod Razeghi, Ioannis Ntalas, Waqar Aziz, Jonathan M Behar, Rebecca Preston, Brian Campbell, Simon Redwood, Bernard Prendergast, Steven Niederer, Ronak Rajani
OBJECTIVES: The primary aim of this study was to quantify the dimensions and geometry of the mitral valve complex in patients with dilated cardiomyopathy and significant mitral regurgitation. The secondary aim was to evaluate the validity of an automated segmentation algorithm for assessment of the mitral valve compared to manual assessment on computed tomography. BACKGROUND: Transcatheter mitral valve replacement (TMVR) is an evolving technique which relies heavily on the lengthy evaluation of cardiac computed tomography (CT) datasets...
April 21, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29743999/transcatheter-mitral-valve-replacement-for-native-and-failed-bioprosthetic-mitral-valves
#2
REVIEW
Kunal Sarkar, Michael J Reardon, Stephen H Little, Colin M Barker, Neal S Kleiman
Transcatheter mitral valve replacement (TMVR) is a novel approach for treatment of severe mitral regurgitation. A number of TMVR devices are currently undergoing feasibility trials using both transseptal and transapical routes for device delivery. Overall experience worldwide is limited to fewer than 200 cases. At present, the 30-day mortality exceeds 30% and is attributable to both patient- and device-related factors. TMVR has been successfully used to treat patients with degenerative mitral stenosis (DMS) as well as failed mitral bioprosthesis and mitral repair using transcatheter mitral valve-in-valve (TMViV)/valve-in-ring (ViR) repair...
July 2017: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/29699609/1-year-outcomes-of-transcatheter-mitral-valve-replacement-in-patients-with-severe-mitral-annular-calcification
#3
Mayra Guerrero, Marina Urena, Dominique Himbert, Dee Dee Wang, Mackram Eleid, Susheel Kodali, Isaac George, Tarun Chakravarty, Moses Mathur, David Holzhey, Ashish Pershad, H Kenith Fang, Daniel O'Hair, Noah Jones, Vaikom S Mahadevan, Nicolas Dumonteil, Josep Rodés-Cabau, Nicolo Piazza, Enrico Ferrari, Daniel Ciaburri, Mohammed Nejjari, Augustin DeLago, Paul Sorajja, Firas Zahr, Vivek Rajagopal, Brian Whisenant, Pinak Bipin Shah, Jan-Malte Sinning, Adam Witkowski, Helene Eltchaninoff, Danny Dvir, Bena Martin, Guilherme F Attizzani, Diego Gaia, Nagela S V Nunes, Amir-Ali Fassa, Faraz Kerendi, Gregory Pavlides, Vijay Iyer, Georges Kaddissi, Christian Witzke, James Wudel, Gregory Mishkel, Bryan Raybuck, Chi Wang, Ron Waksman, Igor Palacios, Alain Cribier, John Webb, Vinnie Bapat, Mark Reisman, Raj Makkar, Martin Leon, Charanjit Rihal, Alec Vahanian, William O'Neill, Ted Feldman
BACKGROUND: The risk of surgical mitral valve replacement in patients with severe mitral annular calcification (MAC) is high. Several patients worldwide with severe MAC have been treated successfully with transcatheter mitral valve replacement (TMVR) using balloon-expandable aortic transcatheter valves. The TMVR in MAC Global Registry is a multicenter registry that collects data on outcomes of these procedures. OBJECTIVES: The goal of this study was to evaluate 1-year outcomes in this registry...
May 1, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29656614/6-minute-walk-test-predicts-prolonged-hospitalization-in-patients-undergoing-transcatheter-mitral-valve-repair-by-mitraclip
#4
Mike Saji, Marc R Katz, Gorav Ailawadi, Timothy S Welch, Dale E Fowler, Jamie L W Kennedy, James D Bergin, Ivandito Kuntjoro, John M Dent, Michael Ragosta, D Scott Lim
BACKGROUND: The 6-minute walk test (6MWT) is a simple functional test that can predict exercise capacity and is widely employed to assess treatment outcomes. Although mortality with transcatheter mitral valve repair (TMVr) using the MitraClip (Abbott Vascular, Menlo Park, CA) is significantly less than for open mitral valve surgery in high-risk patients, identifying which patient will benefit the most from TMVr remains a concern. There are limited prognostic metrics guiding patient selection and, no studies have reported relationship between prolonged hospitalization and 6MWT...
April 15, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29625648/role-of-echocardiography-in-transcatheter-mitral-valve-replacement-in-native-mitral-valves-and-mitral-rings
#5
REVIEW
G Burkhard Mackensen, James C Lee, Dee Dee Wang, Paul J Pearson, Philipp Blanke, Danny Dvir, James N Kirkpatrick
Adaptation and evolution of transcatheter aortic valve replacement (TAVR) technologies has led to approval of TAVR for consideration in patients at intermediate risk for surgical aortic valve intervention. As TAVR becomes more mainstream, attention is shifting toward percutaneous mitral valve (MV) repair and transcatheter MV replacement (TMVR) techniques. Transcatheter heart valves (both purpose-built and off-label-use TAVR valves) are being implanted during TMVR procedures to treat clinically significant MV disease (native disease, degenerated bioprosthetic valves, and dysfunctional surgical MV annuloplasty repairs) when the risk of open heart MV surgery is prohibitive...
April 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29397884/comparison-of-transcatheter-mitral-valve-repair-versus-surgical-mitral-valve-repair-in-patients-with-advanced-kidney-disease-from-the-national-inpatient-sample
#6
Rajkumar Doshi, Evan Shlofmitz, Jay Shah, Perwaiz Meraj
Transcatheter mitral valve repair (TMVR) is an emerging treatment modality that has been reserved for high-risk patients with multiple co-morbidities. We hypothesize that TMVR is a safe and effective procedure for patients with moderate to severe mitral regurgitation who are not surgical candidates. The National Inpatient Sample (2012 to 2014) using the International Classification of Diseases, 9th Revision, Clinical Modification procedure codes 35.97 for TMVR and 35.12 for surgical mitral valve repair (SMVR) were used...
March 15, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29359388/three-dimensional-prototyping-for-procedural-simulation-of-transcatheter-mitral-valve-replacement-in-patients-with-mitral-annular-calcification
#7
Abdallah El Sabbagh, Mackram F Eleid, Jane M Matsumoto, Nandan S Anavekar, Mohammed A Al-Hijji, Sameh M Said, Vuyisile T Nkomo, David R Holmes, Charanjit S Rihal, Thomas A Foley
INTRODUCTION: Three-dimensional (3D) prototyping is a novel technology which can be used to plan and guide complex procedures such as transcatheter mitral valve replacement (TMVR). METHODS: Eight patients with severe mitral annular calcification (MAC) underwent TMVR. 3D digital models with digital balloon expandable valves were created from pre-procedure CT scans using dedicated software. Five models were printed. These models were used to assess prosthesis sizing, anchoring, expansion, paravalvular gaps, left ventricular outflow tract (LVOT) obstruction, and other potential procedure pitfalls...
January 23, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29331957/mitral-valve-anatomic-predictors-of-hemodynamic-success-with-transcatheter-mitral-valve-repair
#8
Jeremy J Thaden, Joseph F Malouf, Vuyisile T Nkomo, Sorin V Pislaru, David R Holmes, Guy S Reeder, Charanjit S Rihal, Mackram F Eleid
BACKGROUND: Mitral regurgitation is a heterogeneous disease. Determining which patients derive optimal outcomes from transcatheter edge-to-edge mitral valve repair (TMVR) remains challenging. We sought to determine whether baseline mitral valve anatomic characteristics are predictive of left atrial pressure (LAP) changes during TMVR with MitraClip. METHODS AND RESULTS: Consecutive patients with severe mitral regurgitation undergoing TMVR (n=112) underwent continuous intraprocedural LAP monitoring and retrospective echocardiographic analysis for specific mitral anatomic characteristics...
January 13, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29325012/systematic-review-of-the-cost-effectiveness-of-transcatheter-interventions-for-valvular-heart-disease
#9
Fotini Gialama, Panagiotis Prezerakos, Vasilis Apostolopoulos, Nikolaos Maniadakis
Transcatheter aortic valve implantation (TAVI) and transcatheter mitral valve repair (TMVR) are increasingly used for managing patients with valvular heart disease to whom surgery presents a high-risk. As these are costly procedures, a systematic review of studies concerned with their economic assessment was undertaken. The search was performed in PubMed and the Cochrane Library and followed recommended methodological steps. Studies were screened and their data were retrieved and were synthesized using a narrative approach...
April 1, 2018: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/29304514/antithrombotic-treatment-after-transcatheter-heart-valves-implant
#10
Sabato Sorrentino, Gennaro Giustino, Kamilia Moalem, Ciro Indolfi, Roxana Mehran, George D Dangas
Transcatheter heart valve replacement technology was introduced as alternative to surgery for the growing high-risk profile population. Developed first, aortic valve replacement (TAVR) became a standard of care for patients with severe aortic stenosis at high operative risk, with a potential future use also for low-risk subjects. In the last decade, a multitude of transcatheter mitral valve replacement (TMVR) devices have been developed for the treatment of severe mitral regurgitation, with encouraging results coming from first-in-man and feasibility studies...
February 2018: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/29301625/tmvr-with-artificial-cords-in-the-treatment-of-mitral-regurgitation-more-questions-than-answers
#11
EDITORIAL
Michael Mack, Robert Smith
No abstract text is available yet for this article.
January 2, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29226591/validating-a-prediction-modeling-tool-for-left-ventricular-outflow-tract-lvot-obstruction-after-transcatheter-mitral-valve-replacement-tmvr
#12
Dee Dee Wang, Marvin H Eng, Adam B Greenbaum, Eric Myers, Michael Forbes, Patrick Karabon, Milan Pantelic, Thomas Song, Jeff Nadig, Mayra Guerrero, William W O'Neill
OBJECTIVE: Demonstrate proof-of-concept validation of a computed tomography (CT) computer-aided design prediction modeling tool to identify patients at risk for left ventricular outflow tract (LVOT) obstruction in transcatheter mitral valve replacement (TMVR). BACKGROUND: LVOT obstruction is a significant and even fatal consequence of TMVR. METHODS: From August 2013 to August 2017, 38 patients in 5 centers underwent TMVR with compassionate use of balloon-expandable valves for severe mitral valve dysfunction because of degenerative surgical mitral ring, bioprosthesis, or severe native mitral stenosis from to severe mitral annular calcification...
December 11, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29208574/experimental-validation-of-tmvr-technologies-a-bumpy-road-with-the-risk-of-getting-lost-in-translation
#13
Azeem Latib, Juan Granada
No abstract text is available yet for this article.
December 8, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29171684/comparison-of-left-atrial-pressure-monitoring-with-dedicated-catheter-versus-steerable-guiding-catheter-during-transcatheter-mitral-valve-repair
#14
Mackram F Eleid, Guy S Reeder, Charanjit S Rihal
OBJECTIVE: The objective of this study was to determine the accuracy of left atrial pressure (LAP) measurement through the manufacturer provided steerable guiding catheter (SGC) during transcatheter mitral valve repair (TMVR). BACKGROUND: LAP measurement during TMVR has been shown to be associated with clinical improvement when measured through a dedicated catheter. METHODS: Simultaneous LAP was performed in consecutive patients using an independent fluid-filled 4F multipurpose catheter and compared to LAP waveforms measured through the manufacturer-provided MitraClip SGC during TMVR (Abbott, Santa Clara, CA)...
November 24, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29105964/simultaneous-transcatheter-transfemoral-aortic-and-transeptal-mitral-valve-replacement-using-edward-sapien-s3
#15
Zaher Fanari, Hadi Mahmaljy, Shalish Nandish, Nilesh J Goswami
Patients with concomitant severe aortic stenosis (AS) and severe mitral stenosis (MS) with mitral annular calcification (MAC) constitute an elderly high-risk population with multiple baseline comorbidities that coexist even before they develop severe valvular dysfunction. Transcatheter mitral valve replacements (TMVR) offer an alternative option for high-risk patient with severe MS with MAC. A simultaneous transfemoral Transcatheter aortic valve replacement (TAVR) and transseptal TMVR is feasible and offers the least invasive approach of management...
November 6, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29102689/early-experience-with-new-transcatheter-mitral-valve-replacement
#16
Vinayak Bapat, Vivek Rajagopal, Christopher Meduri, R Saeid Farivar, Antony Walton, Stephen J Duffy, Robert Gooley, Aubrey Almeida, Michael J Reardon, Neal S Kleiman, Konstantinos Spargias, Stratis Pattakos, Martin K Ng, Michael Wilson, David H Adams, Martin Leon, Michael J Mack, Sharla Chenoweth, Paul Sorajja
BACKGROUND: Transcatheter mitral valve replacement (TMVR) is a potential therapy for patients with symptomatic, severe mitral regurgitation (MR). The feasibility of this therapy remains to be defined. OBJECTIVES: The authors report their early experience with TMVR using a new valve system. METHODS: The valve is a self-expanding, nitinol valve with bovine pericardial leaflets that is placed using a transapical delivery system. Patients with symptomatic MR who were deemed high or extreme risk by the local heart teams were enrolled in a global pilot study at 14 sites (United States, Australia, and Europe)...
January 2, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29096802/first-tmvr-enters-u-s-market-as-a-therapy-%C3%A2-and-a-gateway
#17
EDITORIAL
Steven F Bolling
No abstract text is available yet for this article.
November 7, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28982555/transseptal-transcatheter-mitral-valve-replacement-using-balloon-expandable-transcatheter-heart-valves-a-step-by-step-approach
#18
REVIEW
Marina Urena, Dominique Himbert, Eric Brochet, Jose Luis Carrasco, Bernard Iung, Patrick Nataf, Alec Vahanian
Transcatheter mitral valve replacement (TMVR) using balloon-expandable valves has become an alternative therapy for selected patients with mitral valve disease. Up to now, the transapical approach has been the preferred route, but the transseptal approach is becoming increasingly popular due to its reduced invasiveness and increased safety. However, transseptal TMVR procedures are technically challenging, and little is known about the screening process required before this therapy. The authors provide operators with a step-by-step approach from the screening process to follow-up care for transseptal TMVR procedures...
October 9, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28942390/imaging-for-structural-heart-procedures-focus-on-computed-tomography
#19
John Mooney, Stephanie L Sellers, Mickaël Ohana, João L Cavalcante, Chesnal D Arepalli, Rominder Grover, Ung Kim, Kapilan Selvakumar, Philipp Blanke, Jonathon A Leipsic
The success and continued rapid clinical integration of transcatheter valve technologies relies on imaging modalities to guide safe and effective device deployment. In particular, cardiac imaging, using both echocardiography and CT, is an integral resource for the multidisciplinary team. These modalities can provide valuable insight for the proceduralist at each stage of transcatheter-based valve insertion, as they can be used reliably to define the anatomy of interest and its relationship to surrounding structures, determine accurate device sizing, assess patients for valve-in-valve procedures, and screen for adverse features or procedural contraindications...
September 24, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28942384/transcatheter-mitral-valve-replacement-device-landscape-and-early-results
#20
Amisha Patel, Vinayak Bapat
Mitral regurgitation (MR) is the second most common valvular heart disease in the western world with a prevalence in the USA alone of two to four million people. MR is age-dependent and hence the MR burden is expected to increase with the increase in life expectancy observed in Europe and the USA. Medical and surgical treatment has been the cornerstone of the treatment as untreated MR results in poor prognosis. However, only a fraction of patients are offered surgical treatment due to high risk. With the success of transcatheter aortic valve implantation (TAVI), many transcatheter options have emerged to provide a less invasive option for these patients...
September 24, 2017: EuroIntervention
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