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https://www.readbyqxmd.com/read/28443506/catestain-a-master-regulator-of-cardiovascular-functions
#1
Sushil K Mahata, Malapaka Kiranmayi, Nitish R Mahapatra
Cardiovascular disease (CVD), the most common cause of death globally, accounts for ~30% of all deaths worldwide. Hypertension is a common contributor to morbidity and mortality from CVD. The plasma concentration of chromogranin A (CgA) is elevated in patients with CVD as well as patients with established human essential hypertension and heart failure (HF). In contrast, the plasma level of the CgA-derived peptide catestatin (CST) is diminished in human essential hypertension. Low conversion of CgA-to-CST has been associated with increased mortality in patients hospitalized with acute HF...
April 24, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28440067/real-life-data-regard%C3%A4-ng-acute-procedural-success-and-1-year-clinical-outcome-of-desolve-bioresorbable-scaffolds
#2
Haci Murat Gunes, Tayyar Gokdeniz, Filiz Kizilirmak Yilmaz, Gultekin Gunhan Demir, Ekrem Guler, Gamze Babur Guler, Oğuz Karaca, Beytullah Cakal, Mehmet Onur Omaygenç, Ersin İbişoğlu, Bilal Boztosun
OBJECTIVES: We aimed to evaluate the peri-procedural success of DESolve bio-resorbable scaffolds (BRSs) and analyzed real-life data about major cardiac events during 1-year follow-up. BACKGROUND: There is little information about real-life data of DESolve BRS which is a novel stent technology offering various advantages over drug eluting stents and commonly used in daily cardiology practice. METHODS: We conducted this single-center and non-randomized cross-sectional study from June 2015 through August 2016 in Medipol University Department of Cardiology and included 117 patients undergoing single or multivessel percutaneous coronary interventions (PCI) with novolimus-eluting BRS devices (152 scaffolds) (Elixir Medical Corporation)...
April 25, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28439285/a-quantitative-proteomic-analysis-of-brassinosteroid-induced-protein-phosphorylation-in-rice-oryza-sativa-l
#3
Yuxuan Hou, Jiehua Qiu, Yifeng Wang, Zhiyong Li, Juan Zhao, Xiaohong Tong, Haiyan Lin, Jian Zhang
The group of polyhydroxysteroid phytohormones referred to as the brassinosteroids (BRs) is known to act on plant development and the stress response. BR signal transduction relies largely on protein phosphorylation. By employing a label-free, MS (Mass Spectrometry)-based phosphoproteomic approach, we report here the largest profiling of 4,034 phosphosites on 1,900 phosphoproteins from rice young seedlings and their dynamic response to BR. 1,821 proteins, including kinases, transcription factors and core components of BR and other hormone signaling pathways, were found to be differentially phosphorylated during the BR treatment...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28438793/brassinosteroid-biosynthesis-is-modulated-via-a-transcription-factor-cascade-of-cog1-pif4-and-pif5
#4
Zhuoyun Wei, Tong Yuan, Danuše Tarkowská, Jeongsik Kim, Hong Gil Nam, Ondřej Novák, Kai He, Xiaoping Gou, Jia Li
Brassinosteroids (BRs) are essential phytohormones regulating various developmental and physiological processes during normal growth and development. cog1-3D (cogwheel 1-3D) was identified as an activation-tagged genetic modifier of bri1-5, an intermediate BR receptor mutant. COG1 encodes a Dof-type transcription factor previously found to act as a negative regulator of the phytochrome signaling pathway. cog1-3D single mutants show an elongated hypocotyl phenotype under light conditions. Loss-of-function by ethylmethanoesulfonate (EMS) mutation or inducible expression of a dominant-negative form of COG1 results in an opposite phenotype...
April 24, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28431030/using-multivariate-base-rates-to-interpret-low-scores-on-an-abbreviated-battery-of-the-delis-kaplan-executive-function-system
#5
Justin E Karr, Mauricio A Garcia-Barrera, James A Holdnack, Grant L Iverson
Objective: Executive function consists of multiple cognitive processes that operate as an interactive system to produce volitional goal-oriented behavior, governed in large part by frontal microstructural and physiological networks. Identification of deficits in executive function in those with neurological or psychiatric conditions can be difficult because the normal variation in executive function test scores, in healthy adults when multiple tests are used, is largely unknown. This study addresses that gap in the literature by examining the prevalence of low scores on a brief battery of executive function tests...
May 1, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28420362/clinical-hemispheric-and-autonomic-changes-associated-with-use-of-closed-loop-allostatic-neurotechnology-by-a-case-series-of-individuals-with-self-reported-symptoms-of-post-traumatic-stress
#6
Charles H Tegeler, Jared F Cook, Catherine L Tegeler, Joshua R Hirsch, Hossam A Shaltout, Sean L Simpson, Brian C Fidali, Lee Gerdes, Sung W Lee
BACKGROUND: The objective of this pilot study was to explore the use of a closed-loop, allostatic, acoustic stimulation neurotechnology for individuals with self-reported symptoms of post-traumatic stress, as a potential means to impact symptomatology, temporal lobe high frequency asymmetry, heart rate variability (HRV), and baroreflex sensitivity (BRS). METHODS: From a cohort of individuals participating in a naturalistic study to evaluate use of allostatic neurotechnology for diverse clinical conditions, a subset was identified who reported high scores on the Posttraumatic Stress Disorder Checklist (PCL)...
April 19, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28420238/the-role-of-ti-buffer-layer-thickness-on-the-resistive-switching-properties-of-hafnium-oxide-based-resistive-switching-memories
#7
Sk Ziaur Rahaman, Yu-De Lin, Heng-Yuan Lee, Yu-Sheng Chen, Pang-Shiu Chen, Wei-Su Chen, Chien-Hua Hsu, Kan-Hsueh Tsai, Ming-Jinn Tsai, Pei-Hua Wang
Ti/HfOx ‒based resistive random access memory (RRAM) has been extensively investigated as one of the emerging nonvolatile memory (NVM) candidates due to its excellent memory performance and CMOS process compatibility. Although the importance of the role of the Ti buffer layer is well recognized, the detailed understanding about Ti thickness dependent asymmetric switching nature is still missing. To realize this, the present work addresses the effects of the Ti buffer layer thickness on the switching properties of the TiN/Ti/HfOx/TiN 1T1R RRAM...
April 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28419789/overlapping-bioresorbable-scaffolds-seems-safe-for-now
#8
EDITORIAL
Jorge A Belardi, Mariano Albertal
Overlapping permanent scaffolds carries a long-term risk of target vessel failure due to late malapposition and the development of neoatherosclerosis. Potentially, overlapping bioresorbable scaffold (BRS) may lead to lower long-term risk. The GHOST-EU registry reported similar short- and mid-term risks in patients with and without BRS overlap. Larger size studies with longer follow-up are needed to confirm the safety of BRS overlap.
April 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28419371/sleep-a-window-into-autonomic-control-in-children-born-preterm-and-growth-restricted
#9
Stephanie R Yiallourou, Euan M Wallace, Christie Whatley, Alexsandria Odoi, Samantha Hollis, Aidan J Weichard, Jayan Shivanandhan Muthusamy, Suraj Varma, James Cameron, Om Narayan, Rosemary Sc Horne
Study Objectives: Preterm birth and fetal growth restriction (FGR) are both associated with risk of hypertension in adulthood. Mechanisms leading to this pathology are unclear. In children aged 5-12 years, who were born preterm and FGR, we used sleep as a tool to assess autonomic control with assessment of cardiovascular structure and function. Methods: 18 children born preterm and FGR, 15 born preterm with appropriate birth weights (AGA) and 20 AGA term-born children were studied...
April 17, 2017: Sleep
https://www.readbyqxmd.com/read/28416987/importance-of-exercise-testing-shortly-after-subcutaneous-implantable-cardioverter-defibrillator-implantation-in-patients-with-brugada-syndrome-the-first-case-of-associated-inappropriate-shock-in-japan
#10
Kohei Ishibashi, Takashi Noda, Tsukasa Kamakura, Mitsuru Wada, Yuko Inoue, Hideo Okamura, Kengo Kusano
We report the case of a 51-year-old patient with Brugada syndrome (BrS) who experienced inappropriate shock due to T-wave oversensing (TWOS) during exercise when the optimal sensing vector was selected based on the automatic analysis by a subcutaneous implantable cardioverter-defibrillator (S-ICD). After selecting another vector during exercise testing, TWOS did not re-occur. Selection of appropriate sensing vector based on analyses under various conditions, including during exercise after S-ICD implantation, should be considered for patients with BrS...
April 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28411139/the-quidam-study-hydroquinidine-therapy-in-the-management-of-brugada-syndrome-patients-at-high-arrhythmic-risk
#11
Antoine Andorin, Jean-Baptiste Gourraud, Jacques Mansourati, Swanny Fouchard, Hervé le Marec, Philippe Maury, Philippe Mabo, Jean-Sylvain Hermida, Jean-Claude Deharo, Beatrice Delasalle, Simon Esnault, Nicolas Sadoul, Jean-Marc Davy, Antoine Leenhardt, Didier Klug, Pascal Defaye, Dominique Babuty, Frédéric Sacher, Vincent Probst
BACKGROUND: Although the implantable cardiac defibrillator (ICD) remains the main therapy in Brugada syndrome (BrS), it does not reduce life-threatening ventricular arrhythmia. Based on pathophysiological mechanisms, hydroquinidine (HQ) has been suggested for the effective prevention of arrhythmia. OBJECTIVE: To provide evidence-based data supporting HQ use to prevent life threatening ventricular arrhythmia in high-risk patients with BrS. METHODS: We performed a prospective multicentre randomised (HQ vs...
April 11, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28402719/ospra2-fine-tunes-rice-brassinosteroid-receptor
#12
Xiaoguang Song, Hongyan Guo, Ge Zhang, Yao Wu, Guiling Wang, Xiaoying Chen, Rongxiang Fang
Brassinosteroids (BRs) are a kind of plant hormones that regulate many important agronomic traits. Although the framework of the BR signaling pathway has been outlined, detailed working mechanisms at several steps of this pathway, especially at the BR receptor level, need to be further elucidated. Recently we have reported that a rice small G protein, OsPRA2, bound to the BR receptor OsBRI1 at the plasma membrane (PM) and inhibited its kinase activity and its interaction with the co-receptor OsBAK1, leading to a lower sensitivity to BR treatment and dephosphorylation of OsBZR1...
March 4, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28401855/brugada-syndrome-and-calcium-channel-mutation-in-a-patient-with-congenital-deaf-mutism
#13
Uğur Canpolat, Cem Coteli, Kudret Aytemir
To the best of our knowledge, for the first time in the literature, we described a congenitally deaf-mute patient with Brugada syndrome (BrS) in whom a mutation in L-type Ca(+2) channel [CACNA1C (Cav1.2α1)] was identified.
January 2017: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/28399399/sinat-e3-ligases-control-the-light-mediated-stability-of-the-brassinosteroid-activated-transcription-factor-bes1-in-arabidopsis
#14
Mengran Yang, Chengxiang Li, Zhenying Cai, Yinmeng Hu, Trevor Nolan, Feifei Yu, Yanhai Yin, Qi Xie, Guiliang Tang, Xuelu Wang
The plant hormones brassinosteroids (BRs) participate in light-mediated regulation of plant growth, although the underlying mechanisms are far from being fully understood. In addition, the function of the core transcription factor in the BR signaling pathway, BRI1-EMS-SUPPRESSOR 1 (BES1), largely depends on its phosphorylation status and its protein stability, but the regulation of BES1 is not well understood. Here, we report that SINA of Arabidopsis thaliana (SINATs) specifically interact with dephosphorylated BES1 and mediate its ubiquitination and degradation...
April 10, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28399043/different-estimation-methods-of-spontaneous-baroreflex-sensitivity-have-different-predictive-value-in-heart-failure-patients
#15
Gian Domenico Pinna, Alberto Porta, Roberto Maestri, Beatrice De Maria, Laura Adelaide Dalla Vecchia, Maria Teresa La Rovere
OBJECTIVE: Several methods have been developed so far to estimate cardiac baroreflex sensitivity (BRS) through the analysis of spontaneous fluctuations of systolic arterial pressure (SAP) and R-R interval. Their relative performance in predicting cardiac mortality in heart failure patients is not known. The aim of this study was to compare the prognostic value of a set of representative indexes of spontaneous BRS in these patients. METHODS: We studied 228 stable, moderate-to-severe heart failure patients with reduced ejection fraction, in sinus rhythm, who underwent an 8-min supine recording of ECG, arterial blood pressure and respiration during paced breathing (15 breaths/min)...
April 10, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28398396/-bioresorbable-vascular-scaffolds-clinical-experience-of-the-emilia-romagna-region-italy
#16
Alberto Menozzi, Gianluca Calogero Campo, Vincenzo Guiducci, Gianni Dall'Ara, Andrea Santarelli, Paolo Sbarzaglia, Marco Balducelli, Paolo Magnavacchi, Fabio Sgura, Luciano Losi, Luigi Vignali, Gianni Casella, Luigi Steffanon, Fabio Tarantino, Francesco Saia
BACKGROUND: The bioresorbable vascular scaffold (BRS) technology constitutes the new revolution of the coronary artery disease interventional treatment. Currently, three distinct types of BRSs are available but only one, the Absorb BVS, was on the market in 2013 when the Regional Commission for Medical Devices and the Cardiology and Cardiac Surgery Commission of the Emilia-Romagna Region drew up a technical and scientific essay to provide guidance for the introduction of BRS in public and affiliated health facilities...
February 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/28394206/nitrification-denitrification-and-dephosphatation-capability-of-activated-sludge-during-co-treatment-of-intermediate-age-landfill-leachates-with-municipal-wastewater
#17
S Fudala-Ksiazek, E Kulbat, A Luczkiewicz
This study focuses on the possible use and efficacy of the co-treatment of landfill leachate (intermediate-age) with municipal wastewater. The nitrification, denitrification and dephosphatation capability of activated sludge acclimated with a mixture of raw municipal wastewater (RWW) with gradually increasing amounts of raw landfill leachate (RLL) (from 0.5 to 5% v/v) were tested. Biochemical tests were performed simultaneously in batch reactors (BRs). According to the obtained data, the ammonia utilization rate (AUR) was 3...
April 10, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28391114/genotype-phenotype-dilemma-in-a-case-of-sudden-cardiac-death-with-the-e1053k-mutation-and-a-deletion-in-the-scn5a-gene
#18
T Jenewein, B M Beckmann, S Rose, H H Osterhues, U Schmidt, C Wolpert, P Miny, C Marschall, M Alders, C R Bezzina, A A M Wilde, S Kääb, S Kauferstein
Mutations in the cardiac sodium channel gene SCN5A may result in various arrhythmia syndromes such as long QT syndrome type 3 (LQTS), Brugada syndrome (BrS), sick sinus syndrome (SSS), cardiac conduction diseases (CCD) and possibly dilated cardiomyopathy (DCM). In most of these inherited cardiac arrhythmia syndromes the phenotypical expression may range from asymptomatic phenotypes to sudden cardiac death (SCD). A 16-year-old female died during sleep. Autopsy did not reveal any explanation for her death and a genetic analysis was performed...
March 20, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28376102/the-association-between-autonomic-dysfunction-inflammation-and-atherosclerosis-in-men-under-investigation-for-carotid-plaques
#19
Marcus A Ulleryd, Ulrica Prahl, Johannes Börsbo, Caroline Schmidt, Staffan Nilsson, Göran Bergström, Maria E Johansson
BACKGROUND: Autonomic dysfunction is a risk factor for cardiovascular disease (CVD), however, the exact mechanism linking autonomic dysfunction to cardiovascular disease is not known. In this study we hypothesized that autonomic dysfunction increases inflammation, which subsequently accelerates atherosclerosis. The aim of the current study was to investigate the association between autonomic tone, inflammation and atherosclerosis. METHODS: 124 men under investigation for carotid atherosclerosis were examined for autonomic function (heart rate variability; HRV and baroreflex sensitivity; BRS), inflammatory markers (white blood cell count; WBCC and C-reactive protein; CRP) and degree of carotid atherosclerosis...
2017: PloS One
https://www.readbyqxmd.com/read/28370079/brassinosteroids-act-as-a-positive-regulator-for-resistance-against-root-knot-nematode-involving-respiratory-burst-oxidase-homolog-dependent-activation-of-mapks-in-tomato
#20
Liu-Xia Song, Xue-Chen Xu, Fa-Nan Wang, Yu Wang, Xiao-Jian Xia, Kai Shi, Yan-Hong Zhou, Jie Zhou, Jing-Quan Yu
Interplay of hormones with reactive oxygen species (ROS) fine-tunes the response of plants to stress, however, the crosstalk between brassinosteroids (BRs) and ROS in nematode resistance is unclear. In this study, we found that low BR biosynthesis or lack of BR receptor increased whilst exogenous BR decreased the susceptibility of tomato plants to Meloidogyne incognita. Hormone quantification coupled with hormone mutant complementation experiments revealed that BR did not induce the defense response by triggering salicylic acid (SA), jasmonic acid/ethylene (JA/ET) or abscisic acid (ABA) signaling pathway...
March 29, 2017: Plant, Cell & Environment
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