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https://www.readbyqxmd.com/read/28636908/schiff-base-proton-acceptor-assists-photoisomerization-of-retinal-chromophores-in-bacteriorhodopsin
#1
Chih-Chang Hung, Xiao-Ru Chen, Ying-Kuan Ko, Takayoshi Kobayashi, Chii-Shen Yang, Atsushi Yabushita
In this study, we investigated the ultrafast dynamics of bacteriorhodopsins (BRs) from Haloquadratum walsbyi (HwBR) and Haloarcula marismortui (HmBRI and HmBRII). First, the ultrafast dynamics were studied for three HwBR samples: wild-type, D93N mutation, and D104N mutation. The residues of the D93 and D104 mutants correspond to the control by the Schiff base proton acceptor and donor of the proton translocation subchannels. Measurements indicated that the negative charge from the Schiff base proton acceptor residue D93 interacts with the ultrafast and substantial change of the electrostatic potential associated with chromophore isomerization...
June 20, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28625016/brugada-syndrome-and-exercise-practice-current-knowledge-shortcomings-and-open-questions
#2
Giuseppe Mascia, Elena Arbelo, Jaime Hernández Ojeda, Francesco Solimene, Ramon Brugada, Josep Brugada
Since its recognition as a clinical entity in 1992, the Brugada Syndrome (BrS), a hereditary disease characterized by a typical electrocardiogram (ECG) pattern potentially predisposing to sudden cardiac death (SCD), has attracted the attention of many physicians for its circadian pattern of ventricular arrhythmias (VA), mostly occurring at rest. Exercise may potentially worsen the ECG abnormalities in BrS patients, resulting in higher peak J-point amplitudes during the vasovagal reaction of the recovery period, possibly leading to an increased risk of cardiac events...
June 18, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28605971/impaired-baroreflex-function-during-orthostatic-challenge-in-patients-after-spinal-cord-injury
#3
Katarina Ondrusova, Jana Svacinova, Michal Javorka, Jan Novak, Marie Novakova, Zuzana Novakova
The level of spinal cord injury (SCI) affects baroreflex regulation of blood pressure (BP). While a parasympathetic cardiac chronotropic effect is preserved, baroreflex response could be impaired by sympathetic dysfunction under the SCI level. This study was aimed to evaluate the baroreflex function in SCI patients by the analysis of causal interaction between systolic blood pressure (SBP) and inter-beat intervals (IBI). BP was continuously recorded in 13 cervical SCI patients (CSCI), 9 thoracic SCI (ThSCI) and 13 able-bodied controls (Con) during two phases: sitting (PS) and orthostatic challenge (PO)...
June 12, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28600401/comparison-of-a-drug-free-early-programmed-dismantling-pdlla-bioresorbable-scaffold-and-a-metallic-stent-in-a-porcine-coronary-artery-model-at-3-year-follow-up
#4
Kazuyuki Yahagi, Yi Yang, Sho Torii, Johanne Mensah, Roseann M White, Marion Mathieu, Erica Pacheco, Masataka Nakano, Abdul Barakat, Tahmer Sharkawi, Michel Vert, Michael Joner, Aloke V Finn, Renu Virmani, Antoine Lafont
BACKGROUND: Arterial Remodeling Technologies bioresorbable scaffold (ART-BRS), composed of l- and d-lactyl units without drug, has shown its safety in a porcine coronary model at 6 months. However, long-term performance remains unknown. The aim of this study was to evaluate the ART-BRS compared to a bare metal stent (BMS) in a healthy porcine coronary model for up to 3 years. METHODS AND RESULTS: Eighty-two ART-BRS and 66 BMS were implanted in 64 Yucatan swine, and animals were euthanatized at intervals of 1, 3, 6, 9, 12, 18, 24, and 36 months to determine the vascular response using quantitative coronary angiography, optical coherence tomography, light and scanning electron microscopy, and molecular weight analysis...
June 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28597987/trafficking-and-localization-to-the-plasma-membrane-of-nav-1-5-promoted-by-the-%C3%AE-2-subunit-is-defective-due-to-a-%C3%AE-2-mutation-associated-with-brugada-syndrome
#5
Gemma Dulsat, Sonia Palomeras, Eric Cortada, Helena Riuró, Ramon Brugada, Marcel Vergés
BACKGROUND INFORMATION: Cardiac channelopathies arise by mutations in genes encoding ion channel subunits. One example is Brugada Syndrome (BrS), which causes arrhythmias and sudden death. BrS is often associated with mutations in SCN5A, encoding Nav 1.5, the α subunit of the major cardiac voltage-gated sodium channel. This channel forms a protein complex including one or two associated β subunits as well as other proteins. RESULTS: We analyzed regulation of Nav 1...
June 9, 2017: Biology of the Cell
https://www.readbyqxmd.com/read/28597206/effect-of-strut-distribution-on-neointimal-coverage-of-everolimus-eluting-bioresorbable-scaffolds-an-optical-coherence-tomography-study
#6
Takao Sato, John Jose, Abdelhakim Allai, Mohamed El-Mawardy, Ralph Tölg, Gert Richardt, Mohamed Abdel-Wahab
The thick struts of bioresorbable vascular scaffolds (BRS) are associated with changes in wall shear stress and contribute to neointimal proliferation. We aimed to evaluate the relationship between the BRS strut distribution and the neointimal proliferation. 50 lesions underwent optical coherence tomography, 12 months after BRS implantation. Scaffold area and neointimal thickness were evaluated in each cross-sectional area (CSA). Scaffold eccentricity was defined as follows: (maximum diameter - minimum diameter) × 100/maximum diameter...
June 9, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28592227/long-term-outcome-of-bioresorbable-vascular-scaffolds-for-the-treatment-of-coronary-artery-disease-a-meta-analysis-of-rcts
#7
Alberto Polimeni, Remzi Anadol, Thomas Münzel, Ciro Indolfi, Salvatore De Rosa, Tommaso Gori
BACKGROUND: Coronary bioresorbable scaffolds (BRS) were developed to overcome the limitations of standard metallic stents, especially to address late events after percutaneous coronary interventions. The aim of this meta-analysis was to evaluate the efficacy and safety of BRS, compared with Everolimus-eluting stents (EES), using the data available from randomized trials, with a focus on long-term outcomes. METHODS: Published randomized trials comparing BRS to EES for the treatment of coronary artery disease were searched for within PubMed, Cochrane Library and Scopus electronic databases up to April 4th 2017...
June 7, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28584713/transcriptome-analysis-reveals-the-regulation-of-brassinosteroids-on-petal-growth-in-gerbera-hybrida
#8
Gan Huang, Meixiang Han, Wei Yao, Yaqin Wang
Gerbera hybrida is a cut-flower crop of global importance, and an understanding of the mechanisms underlying petal development is vital for the continued commercial development of this plant species. Brassinosteroids (BRs), a class of phytohormones, are known to play a major role in cell expansion, but their effect on petal growth in G. hybrida is largely unexplored. In this study, we found that the brassinolide (BL), the most active BR, promotes petal growth by lengthening cells in the middle and basal regions of petals, and that this effect on petal growth was greater than that of gibberellin (GA)...
2017: PeerJ
https://www.readbyqxmd.com/read/28584071/scn5a-genetic-polymorphisms-associated-with-increased-defibrillator-shocks-in-brugada-syndrome
#9
Pattarapong Makarawate, Narumol Chaosuwannakit, Suda Vannaprasaht, Dujdao Sahasthas, Seok Hwee Koo, Edmund Jon Deoon Lee, Wichittra Tassaneeyakul, Hector Barajas-Martinez, Dan Hu, Kittisak Sawanyawisuth
BACKGROUND: Brugada syndrome (BrS) is an inherited primary arrhythmia disorder leading to sudden cardiac arrest. SCN5A, encoding the α-subunit of the cardiac sodium channel (Nav1.5), is the most common pathogenic gene of BrS. An implantable cardioverter defibrillator (ICD) is the standard treatment for secondary prevention. This study aimed to evaluate association of the SCN5A variant with this cardiac conduction disturbance and appropriate ICD shock therapy in Thai symptomatic BrS patients with ICD implants...
June 5, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28583685/usefulness-of-the-r-wave-sign-as-a-predictor-for-ventricular-tachyarrhythmia-in-patients-with-brugada-syndrome
#10
Ahmed A Y Ragab, Charlotte A Houck, Lisette J M E van der Does, Eva A H Lanters, Danielle E Burghouwt, Agnes J Q M Muskens, Natasja M S de Groot
Brugada syndrome (BrS) is an autosomal dominant channelopathy which is responsible for a large number of sudden cardiac deaths in young subjects without structural abnormalities. The most challenging step in management of patients with BrS is identifying who is at risk for developing malignant ventricular tachyarrhythmia (VTA). In patients with BrS, conduction delay in the right ventricular outflow tract (RVOT) causes a prominent R wave in lead aVR. This electrocardiographic parameter can be useful to detect these high-risk patients...
May 11, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28582033/bioresorbable-scaffolds-clinical-outcomes-and-considerations
#11
REVIEW
Davide Capodanno
Bioresorbable scaffolds (BRS) have been engineered to eliminate the theoretic stimulus to late coronary events, a caveat of conventional metallic drug-eluting stents (DESs). Outcome benefits of BRSs over current-generation DESs are expected to accrue after complete bioresorption. Before this timeframe, BRSs need to prove at least similarly safe and effective compared with DESs. Several randomized studies of the Absorb BRS have been made available. Several manufacturers are at the beginning of their line of clinical development of competing BRSs...
July 2016: Interventional cardiology clinics
https://www.readbyqxmd.com/read/28582032/design-principles-of-bioresorbable-polymeric-scaffolds
#12
REVIEW
Mary Beth Kossuth, Laura E L Perkins, Richard J Rapoza
The concept for a bioresorbable vascular scaffold combines the best features of the first 3 generations of percutaneous coronary intervention (namely), balloon angioplasty, bare metallic stents, and drug-eluting stents, into a single device. The principles of operation of a BRS follow 3 phases of functionality that reflect the different physiologic requirements over time; revascularization, restoration, and resorption. Most BRS designs make use of the continuum of hydrolytic degradation in aliphatic polyesters, such as poly(l-lactide), in which molecular weight, strength, and mass decrease progressively in 3 distinct stages, consistent with the in vivo requirements of each performance phase...
July 2016: Interventional cardiology clinics
https://www.readbyqxmd.com/read/28580152/brugada-phenocopy-in-a-patient-with-acute-pulmonary-embolism-presenting-with-recurrent-syncope
#13
Nixiao Zhang, Tong Liu, Gary Tse, Shuyu Yu, Huaying Fu, Gang Xu, Changyu Zhou, Chengzong Zhang, Guangping Li
Brugada phenocopy (BrP) refers to a group of clinical conditions that have etiologies distinct from Brugada syndrome (BrS). Although both demonstrate features of ST-segment elevation in the right precordial leads on the electrocardiogram (ECG), one must be distinguished from the other as their treatment options are different. We report a male patient who presented with recurrent syncope with a Brugada and a S1Q3T3 pattern on the ECG. Acute pulmonary embolism (APE) complicated by BrS was suspected. Twenty-four hours Holter monitoring did not demonstrate any evidence of ventricular arrhythmias...
May 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/28579164/impact-of-strut-thickness-on-acute-mechanical-performance-a-comparison-study-using-optical-coherence-tomography-between-desolve-150-and-desolve-100
#14
Niklas F Boeder, Oliver Dörr, Timm Bauer, Alessio Mattesini, Albrecht Elsässer, Christoph Liebetrau, Stephan Achenbach, Christian W Hamm, Holger M Nef
OBJECTIVE: To evaluate the acute performance of a novolimus-eluting bioresorbable scaffold (BRS) with different strut thickness (DESolve system 150 and 100) using optical coherence tomography (OCT) in terms of appropriate scaffold deployment. BACKGROUND: Outcome after BRS implantation seen in registries and meta-analyses continue to show a higher rate of scaffold thrombosis than those reported with DES. Thus, second scaffold generations with lower strut thickness might have potential advantages in terms of flow disturbance...
May 24, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28576847/arabidopsis-wrky46-wrky54-and-wrky70-transcription-factors-are-involved-in-brassinosteroid-regulated-plant-growth-and-drought-response
#15
Jiani Chen, Trevor Nolan, Huaxun Ye, Mingcai Zhang, Hongning Tong, Peiyong Xin, Jinfang Chu, Chengcai Chu, Zhaohu Li, Yanhai Yin
Plant steroid hormones, brassinosteroids (BRs), play important roles in growth and development. BR signaling controls the activities of BRASSINOSTERIOD INSENSITIVE1-EMS-SUPPRESSOR 1/ BRASSINAZOLE-RESISTANT 1 (BES1/BZR1) family transcription factors. Besides the role in promoting growth, BRs are also implicated in plant responses to drought stress. However, the molecular mechanisms by which BRs regulate drought response have just begun to be revealed. However, the functions of WRKY transcription factors in BR-regulated plant growth have not been established, although their roles in stress responses are well documented...
June 2, 2017: Plant Cell
https://www.readbyqxmd.com/read/28572789/impaired-baroreflex-sensitivity-after-bilateral-convulsive-seizures-in-patients-with-focal-epilepsy
#16
Kevin G Hampel, Christian E Elger, Rainer Surges
BACKGROUND: Sudden unexpected death in epilepsy (SUDEP) is probably due to an autonomic failure in the early postictal phase after bilateral convulsive seizures (BCS) in the majority of cases. The baroreflex sensitivity (BRS) is an established and reliable biomarker of autonomic function and sudden cardiac death. OBJECTIVE: To investigate whether postictal BRS depends on seizure type. METHODS: Beat-to-beat systemic blood pressure and heart rate were continuously and non-invasively recorded with the ccNexfin(®) device in patients with focal epilepsy undergoing video-EEG monitoring...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28567047/brassinosteroid-mediated-cell-wall-remodeling-in-grasses-under-abiotic-stress
#17
REVIEW
Xiaolan Rao, Richard A Dixon
Unlike animals, plants, being sessile, cannot escape from exposure to severe abiotic stresses such as extreme temperature and water deficit. The dynamic structure of plant cell wall enables them to undergo compensatory changes, as well as maintain physical strength, with changing environments. Plant hormones known as brassinosteroids (BRs) play a key role in determining cell wall expansion during stress responses. Cell wall deposition differs between grasses (Poaceae) and dicots. Grass species include many important food, fiber, and biofuel crops...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28560713/time-domain-measurement-of-the-vascular-and-myocardial-branches-of-the-baroreflex-a-study-in-physically-active-versus-sedentary-individuals
#18
Gustavo A Reyes Del Paso, Pablo de la Coba, María Martín-Vázquez, Julian F Thayer
This study tests the spontaneous sequence method for the evaluation of the cardiac, vasomotor, and myocardial branches of the baroreflex. Systolic blood pressure (SBP), interbeat interval (IBI), stroke volume (SV), preejection period (PEP), and total peripheral resistance (TPR) were continuously recorded in 33 physically active and 25 sedentary participants at rest and during a mental arithmetic task. Sequences of spontaneous covariation between SBP and IBI (for the cardiac branch), SV and PEP (for the myocardial branch), and TPR (for the vasomotor branch) were located...
May 31, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28557555/effect-of-obstructive-sleep-apnea-on-the-response-to-hypertension-therapy
#19
Michael G Ziegler, Milos Milic, Xiaojiong Lu, Munir Gharaibeh, Hamzeh Elayan
Obstructive sleep apnea (OSA) often precedes cardiovascular disease, partly due to treatment resistant hypertension. The nocturnal apneas of OSA trigger increased sympathetic nervous discharge during both sleep and wakefulness. Apneas also trigger cardiac release of the endogenous diuretic atrial natriuretic peptide. We hypothesized that treatment of the excess sympathetic nervous activity of OSA with a β1 blocker would lower 24 h blood pressure (BP) more than diuretic therapy. Subjects with OSA associated hypertension received 2 weeks of placebo followed by the β1 blocker nebivolol or hydrochlorothiazide (HCTZ) for 6 weeks in a blinded crossover study...
May 30, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28545487/inhaled-ambient-level-traffic-derived-particulates-decrease-cardiac-vagal-influence-and-baroreflexes-and-increase-arrhythmia-in-a-rat-model-of-metabolic-syndrome
#20
Alex P Carll, Samir M Crespo, Mauricio S Filho, Douglas H Zati, Brent A Coull, Edgar A Diaz, Rodrigo D Raimundo, Thomas N G Jaeger, Ana Laura Ricci-Vitor, Vasileios Papapostolou, Joy E Lawrence, David M Garner, Brigham S Perry, Jack R Harkema, John J Godleski
BACKGROUND: Epidemiological studies have linked exposures to ambient fine particulate matter (PM2.5) and traffic with autonomic nervous system imbalance (ANS) and cardiac pathophysiology, especially in individuals with preexisting disease. It is unclear whether metabolic syndrome (MetS) increases susceptibility to the effects of PM2.5. We hypothesized that exposure to traffic-derived primary and secondary organic aerosols (P + SOA) at ambient levels would cause autonomic and cardiovascular dysfunction in rats exhibiting features of MetS...
May 25, 2017: Particle and Fibre Toxicology
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