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https://www.readbyqxmd.com/read/29453261/molecular-and-functional-study-of-a-branching-sucrase-like-glucansucrase-reveals-an-evolutionary-intermediate-between-two-subfamilies-of-the-gh70-enzymes
#1
Minghui Yan, Bing-Hua Wang, Xiaofen Xu, Peng Chang, Feng Hang, Zhengjun Wu, Chunping You, Zhenmin Liu
Family GH70 glucansucrases (GSs) catalyze the synthesis of α-glucans from sucrose, a reaction widely seen in lactic acid bacteria (LAB). These enzymes have been implicated in many aspects of the microbial life. Products of GSs have great commercial value as food supplements and medical materials, therefore these enzymes have attracted much attention from both fields of science and industry. However, certain issues concerning the origin and evolution of GS are still to be addressed, although an increasing number of GH70 enzymes have been characterized...
February 16, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29438435/population-based-validation-of-a-german-version-of-the-brief-resilience-scale
#2
Andrea Chmitorz, Mario Wenzel, Rolf-Dieter Stieglitz, Angela Kunzler, Christiana Bagusat, Isabella Helmreich, Anna Gerlicher, Miriam Kampa, Thomas Kubiak, Raffael Kalisch, Klaus Lieb, Oliver Tüscher
Smith and colleagues developed the Brief Resilience Scale (BRS) to assess the individual ability to recover from stress despite significant adversity. This study aimed to validate the German version of the BRS. We used data from a population-based (sample 1: n = 1.481) and a representative (sample 2: n = 1.128) sample of participants from the German general population (age ≥ 18) to assess reliability and validity. Confirmatory factor analyses (CFA) were conducted to compare one- and two-factorial models from previous studies with a method-factor model which especially accounts for the wording of the items...
2018: PloS One
https://www.readbyqxmd.com/read/29433126/mek-drives-braf-activation-through-allosteric-control-of-ksr-proteins
#3
Hugo Lavoie, Malha Sahmi, Pierre Maisonneuve, Sara A Marullo, Neroshan Thevakumaran, Ting Jin, Igor Kurinov, Frank Sicheri, Marc Therrien
RAF family kinases have prominent roles in cancer. Their activation is dependent on dimerization of their kinase domains, which has emerged as a hindrance for drug development. In mammals, RAF family kinases include three catalytically competent enzymes (ARAF, BRAF and CRAF) and two pseudokinases (KSR1 and KSR2) that have been described as scaffolds owing to their apparent ability to bridge RAF isoforms and their substrate, mitogen-activated protein kinase kinase (MEK). Kinase suppressor of Ras (KSR) pseudokinases were also shown to dimerize with kinase-competent RAFs to stimulate catalysis allosterically...
February 12, 2018: Nature
https://www.readbyqxmd.com/read/29432595/dwf1-functions-as-a-c-24-reductase-to-convert-24-methylene-brassinosteroids-to-24-methyl-brassinosteroids-in-arabidopsis-thaliana
#4
Ji Hyun Youn, Tae-Woo Kim, Se-Hwan Joo, Seung-Hyun Son, Jeehee Roh, Sunyoung Kim, Tae-Wuk Kim, Seong-Ki Kim
DWARF1 (DWF1) is a sterol C-24 reductase that catalyzes the conversion of 24-methylenecholesterol (24-MCHR) to campesterol (CR) in Arabidopsis (Arabidopsis thaliana). A loss-of-function mutant, dwf1, showed similar phenotypic abnormalities to brassinosteroid (BR)-deficient mutants. These abnormalities were reversed in the wild-type phenotype by exogenous application of each castasterone (CS) and brassinolide (BL), but not dolichosterone (DS). Accumulation of DS and decreased CS were found in quantitative analysis of endogenous BRs in dwf1...
February 8, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29427889/functional-analysis-of-stdwf4-gene-in-response-to-salt-stress-in-potato
#5
Xiangyan Zhou, Ning Zhang, Jiangwei Yang, Xun Tang, Yikai Wen, Huaijun Si
The DWARF4 (DWF4) gene encodes a C-22 hydroxylase which is pivotal for brassinosteroids (BRs) biosynthesis. In this research, aimed to understand the molecular mechanism of DWF4 on regulation of potatoes tolerance to salt stress, DWF4 was cloned from potato, named as StDWF4. Its 1476 bp open reading frame encodes a protein of 491 amino acids. The StDWF4-overexpressing (OE) and interference-expressing (RNAi) transgenic potato plants were acquired using Agrobacterium-mediated transformation, respectively. Tissue specific analysis using Quantitative real-time polymerase chain reaction (qRT-PCR) demonstrated that the StDWF4 gene expressed in the leaves, stems and roots of the transgenic and un-transgenic (NT) plants, with specially increased (StDWF4-OE)/reduced (StDWF4-RNAi) expression in the roots...
February 2, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29424937/pathogenesis-of-cranial-neuropathies-in-moebius-syndrome-electrodiagnostic-orofacial-studies
#6
Francis Renault, Roberto Flores-Guevara, Bernard Sergent, Jean Jacques Baudon, Jessie Aouizerate, Marie-Paule Vazquez, Cyril Gitiaux
INTRODUCTION: We designed a retrospective study of 59 patients with congenital sporadic non-progressive bilateral facial and abducens palsies. METHODS: Examinations included needle EMG of facial and oral muscles, facial nerve motor latency and conduction velocity (FNCV), and blink responses (BRs). RESULTS: Neurogenic EMG changes were found in one or more muscles in 55/59 patients, with no abnormal spontaneous activity. EMG changes were homogeneously neurogenic in 17 patients, homogeneously myopathic in one, and heterogeneous in 41/59 patients...
February 9, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29415486/impact-of-psp-technique-on-clinical-outcomes-following-bioresorbable-scaffolds-implantation
#7
REVIEW
Luis Ortega-Paz, Salvatore Brugaletta, Manel Sabaté
Bioresorbable scaffolds (BRS) were introduced in clinical practice to overcome the long-term limitations of newer-generation drug-eluting stents. Despite some initial promising results of the Absorb BRS, safety concerns have led to the discontinuation of the commercialization of this device. Several retrospective studies have assessed the impact of the so-called Pre-dilation, Sizing and Post-dilation (PSP) technique concluding that an optimal PSP technique can improve clinical outcomes following BRS implantation...
February 6, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29413240/a-randomized-trial-comparing-the-neovas-sirolimus-eluting-bioresorbable-scaffold-and-metallic-everolimus-eluting-stents
#8
Yaling Han, Bo Xu, Guosheng Fu, Xiaozeng Wang, Kai Xu, Chongying Jin, Ling Tao, Lang Li, Yuqing Hou, Xi Su, Quan Fang, Lianglong Chen, Huiliang Liu, Bin Wang, Zuyi Yuan, Chuanyu Gao, Shenghua Zhou, Zhongwei Sun, Yanyan Zhao, Changdong Guan, Gregg W Stone
OBJECTIVES: The authors sought to evaluate the safety and effectiveness of the NeoVas bioresorbable scaffold (BRS) compared with metallic drug-eluting stents. BACKGROUND: BRS have the potential to improve very late outcomes compared with metallic drug-eluting stents, but some BRS have been associated with increased rates of device thrombosis before complete bioresorption. NeoVas is a new poly-l-lactic acid BRS that elutes sirolimus from a poly-D, l-lactide coating...
February 12, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29410320/a-possible-new-target-in-lung-cancer-cells-the-orphan-receptor-bombesin-receptor-subtype-3
#9
Paola Moreno, Samuel A Mantey, Suk H Lee, Irene Ramos-Álvarez, Terry W Moody, Robert T Jensen
Human bombesin receptors, GRPR and NMBR, are two of the most frequently overexpressed G-protein-coupled-receptors by lung-cancers. Recently, GRPR/NMBR are receiving considerable attention because they act as growth factor receptors often in an autocrine manner in different lung-cancers, affect tumor angiogenesis, their inhibition increases the cytotoxic potency of tyrosine-kinase inhibitors reducing lung-cancer cellular resistance/survival and their overexpression can be used for sensitive tumor localization as well as to target cytotoxic agents to the cancer...
February 2, 2018: Peptides
https://www.readbyqxmd.com/read/29403393/an-innovative-technique-to-assess-spontaneous-baroreflex-sensitivity-with-short-data-segments-multiple-trigonometric-regressive-spectral-analysis
#10
Kai Li, Heinz Rüdiger, Rocco Haase, Tjalf Ziemssen
Objective: As the multiple trigonometric regressive spectral (MTRS) analysis is extraordinary in its ability to analyze short local data segments down to 12 s, we wanted to evaluate the impact of the data segment settings by applying the technique of MTRS analysis for baroreflex sensitivity (BRS) estimation using a standardized data pool. Methods: Spectral and baroreflex analyses were performed on the EuroBaVar dataset (42 recordings, including lying and standing positions). For this analysis, the technique of MTRS was used...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29402494/activation-of-bombesin-receptor-subtype-3-by-d-tyr6-%C3%AE-ala11-phe13-nle14-bombesin6-14-increased-glucose-uptake-and-lipogenesis-in-human-and-rat-adipocytes
#11
Zaida Moreno-Villegas, Antonio Martín-Duce, César Aparicio, Sergio Portal-Núñez, Raúl Sanz, Samuel A Mantey, Robert T Jensen, Oscar Lorenzo, Jesús Egido, Nieves González
BRS-3 has an important role in glucose homeostasis. Its expression was reduced in skeletal muscle from obese and/or diabetic patients, and BRS-3 KO-mice developed obesity. In this work, focused on rat/human adipose tissue, BRS-3 gene-expression was lower than normal-levels in hyperlipidemic, type-2-diabetic (T2D), and type-1-diabetic rats and also in obese (OB) and T2D patients. Moreover, BRS-3 protein levels were decreased in diabetic rat and in obese and diabetic human fat pieces; but neither mutation nor even polymorphism in the BRS-3-gene was found in OB or T2D patients...
January 31, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29401613/receptor-specific-cross-talk-between-prostanoid-3-and-bombesin-subtype-3-receptors
#12
Yan Zhang, Yanfang Liu, Lehao Wu, Chao Fan, Zhiwei Wang, Xiuli Zhang, Amal Alachkar, Xinmiao Liang, Olivier Civelli
Bombesin receptor subtype 3 (BRS-3) is a GPCR that is expressed in the CNS, peripheral tissues, and tumors. Our understanding of BRS-3's role in physiology and pathophysiology is limited because its natural ligand is unknown. In an attempt to identify this ligand, we screened toad skin ( Bufo bufo gargarizans Cantor) extracts and identified prostaglandins as putative ligands. In BRS-3-transfected human embryonic kidney (HEK) cells, we found that prostaglandins, with prostaglandin E2 (PGE2) being the most potent, fulfill the pharmacologic criteria of affinity, selectivity, and specificity to be considered as agonists to the BRS-3 receptor...
January 22, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29397883/relation-of-the-brugada-phenocopy-to-hyperkalemia-from-the-international-registry-on-brugada-phenocopy
#13
Grace Xu, Byron H Gottschalk, Daniel D Anselm, David G Benditt, Ankit Maheshwari, Shiva Sreenivasan, Raed Abu Shama, Gregory Dendramis, Héctor Barajas-Martínez, José Manuel Rubio Campal, Sam G Aznaurov, Adrian Baranchuk
Brugada phenocopies (BrPs) are clinical entities that differ in etiology from true congenital Brugada syndrome but have identical electrocardiographic (ECG) patterns. Hyperkalemia is known to be one of the causes of BrP. The aim of this study was to determine the clinical characteristics and evolution of hyperkalemia-induced BrP. Data from 27 cases of hyperkalemia-induced BrP were collected from the International Registry at www.brugadaphenocopy.com. Data were extracted from publications. Of the 27 patients included in the analysis, 18 (67%) were male; mean age was 53 ± 15 years (range 31 to 89)...
December 29, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29397314/overload-blunts-baroreflex-only-in-overreached-athletes
#14
Nicolas Bourdillon, Sasan Yazdani, Masih Nilchian, Alessio Mariano, Jean-Marc Vesin, Grégoire P Millet
OBJECTIVES: Heart rate variability (HRV) is commonly used to diagnose overreaching and monitor athletes' responses to training. Baroreflex sensitivity (BRS) is modified by changes in training load and might be another means to detect overreaching. The goal of this study was to assess BRS and HRV changes in two groups of athletes responding either negatively (FOR) or positively (AF) to similar training overload. DESIGN: Fifteen athletes performed 2-week baseline (BSL) training followed by 3-week overload (+45%; OVL) and 2-week recovery (-20%; RCV)...
January 31, 2018: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29393601/comprehensive-non-invasive-cardiac-and-autonomic-assessment-in-acute-ischaemic-stroke-patients-pilot-study
#15
Monika Zawadka-Kunikowskaa, Krzysztof Słomiński, Joanna Słomko, Małgorzata Tafil-Klawe, Jacek J Klawe, Łukasz Sokołowski, Julia L Newton, Paweł Zalewski
PURPOSE: The aim of this study was to comprehensively determine haemodynamic and autonomic responses during-head up tilt test (HUT) in the acute and recovery phase of ischemic stroke. METHODS: Cardiovascular parameters, baroreflex sensitivity (BRS), spectral- indices of heart rate (HRV), systolic (sBPV) and diastolic blood pressure variability (dBPV) were measured at rest in ischaemic stroke patients (n=17) and control group (n=34). Dynamic cardiac autonomic function was assessed using HUT (Delta [rest-tilt]...
February 1, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29393253/activation-of-bombesin-receptor-subtype-3-promotes-antigen-presenting-action-in-human-bronchial-epithelial-cells
#16
Huijun Liu, Lihua Peng, Chi Liu, Yurong Tan, Yang Xiang, Xiangping Qu, H Christian Weber, Minhui Dai, Xiaoqun Qin
BACKGROUND: Bombesin receptor subtype-3 (BRS-3) is a member of the bombesin-like peptide receptor family. Our previous studies demonstrated that activation of the human BRS-3 plays a protective role in oxidation-injured human bronchial epithelial cells (HBEC). The present study was designed to determine the role of BRS-3 activation in the antigen-presenting action of HBEC and the corresponding proliferation and differentiation of T cells. MATERIALS AND METHODS: In vivo, an asthma animal model was established and the expression and distribution of BRS-3 were analyzed by immunocytochemistry...
January 27, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29387326/performance-of-electrophysiologic-study-in-an-asymptomatic-patient-with-type-2-intermittent-brugada-syndrome-to-do-or-not-to-do
#17
Kaveh Hosseini, Mansour Jahangiri, Ali Vasheghani Farahani
Background: Brugada syndrome (BrS) is an inherited channelopathy, which is associated with sudden cardiac death due to rapid polymorphic VT or VF. There is no definite consensus regarding the management of asymptomatic patients. Some experts advocate close follow-up; others propose the programmed stimulation for risk stratification. We aimed to evaluate the benefit of complete atrial and ventricular stimulation in patients with BrS and palpitation. Case Presentation: A 30-year-old man was admitted to our hospital because of a family history of sudden cardiac death (SCD) at age less than 45 years...
2018: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/29381953/case-report-an-unusual-case-of-brugada-syndrome-combined-with-a-ventricular-septal-defect-a-case-report
#18
Xing Liu, Jianmei Zheng, Zhongcai Fan, Li Rao
RATIONALE: Brugada syndrome (BrS) is a cardiac ion channel disease that is caused by an autosomal dominant genetic abnormality. A ventricular septal defect is a common congenital heart disease, in which genetic defects play a significant role. PATIENT CONCERNS: We report an extremely rare case of a 42-year-old male with congenital heart disease, who suffered recurrent syncope and gastrointestinal bleeding. His electrocardiogram showed an unusual right bundle branch block-like pattern and ST-segment elevation in leads V1-V3...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29375224/safety-and-efficacy-of-epicardial-ablation-of-ventricular-tachyarrhythmias-experience-from-a-tertiary-referral-center-in-taiwan
#19
Chin-Yu Lin, Fa-Po Chung, Yenn-Jiang Lin, Shih-Lin Chang, Li-Wei Lo, Yu-Feng Hu, Jo-Nan Liao, Ta-Chuan Tuan, Tze-Fan Chao, Yao-Ting Chang, Yun-Yu Chen, Abigail Louise D Te, Shinya Yamada, Shih-Ann Chen
Background: Epicardial catheter ablation has been shown to be an effective strategy for treating ventricular arrhythmias (VA). We investigated the efficacy and safety from a tertiary referral center in Taiwan. Methods: From 2010 to 2016, patients undergoing epicardial ablation for VAs were consecutively enrolled. The clinical characteristics, disease entity, electrophysiological studies, and ablation outcome were extracted for further analysis. Results: A total of 80 patients were eligible, including 34 patients for arrhythmogenic right ventricular cardiomyopathy (ARVC), 16 for Brugada syndrome (BrS), 13 for idiopathic VAs, 11 for idiopathic dilated cardiomyopathy (IDCM), 2 for ischemic cardiomyopathy, and 4 for other nonischemic cardiomyopathies (NICM)...
January 2018: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29363947/probing-the-mechanism-for-bipolar-resistive-switching-in-annealed-graphene-oxide-thin-films
#20
Pooja Saini, Manjri Singh, Jyoti Thakur, Ranjit A Patil, Yuan-Ron Ma, Ram Pal Tandon, Surinder P Singh, Ajit Kumar Mahapatro
The bipolar resistive switching (BRS) between a metallic low resistance state (LRS) and an insulating high resistance state (HRS) is demonstrated for annealed graphene oxide (GO) thin film based device structures with aluminum (Al) as one of the contact electrodes. An optimal switching of ~104 order is recorded for Al/GO(200°C)/ITO among the device structures in metal(M2)/GO(T)/metal(M1) configurations (M1 = Al, Au, ITO, and M2 = Au, Al), fabricated using GO(T)/metal(M1), annealed at different temperatures, T = 100, 200, 300, and 400 °C...
January 24, 2018: ACS Applied Materials & Interfaces
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