keyword
MENU ▼
Read by QxMD icon Read
search

BRS

keyword
https://www.readbyqxmd.com/read/28540949/structure-based-in-silico-identification-of-potentially-non-steroidal-brassinosteroids-mimics
#1
Beilei Lei, Ningjuan Heng, Xiaoxue Dang, Jiyuan Liu, Xiaojun Yao, Cunli Zhang
Brassinosteroids (BRs) are a class of plant steroid hormones that play indispensable roles in cell elongation, division and plant development. To date, the numerous synthesis of BRs analogs and structure-activity relationship investigations have clearly revealed the key substituent groups relevant to the steroidal activity of BRs. However, due to the limited chemical space studied, the efforts for alternative non-steroidal compounds have produced no remarkable results. To identify potentially non-steroidal BR mimics in this study, vital interacting pharmacophore features were extracted starting from several complex structures of BRs that bound with the receptor Brassinosteroid-Insentive 1 (BRI1) and co-receptor BRI1-associated kinase 1 (BAK1), which were characterized and merged into one comprehensive pharmacophore model...
May 25, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28540554/understanding-brassinosteroid-regulated-mechanisms-to-improve-stress-tolerance-in-plants-a-critical-review
#2
Fahim Nawaz, Muhammad Naeem, Bilal Zulfiqar, Asim Akram, Muhammad Yasin Ashraf, Muhammad Raheel, Rana Nauman Shabbir, Rai Altaf Hussain, Irfan Anwar, Muhammad Aurangzaib
Brassinosteroids (BRs) are steroidal plant hormones involved in regulation of physiological and molecular processes to ameliorate various biotic and abiotic stresses. Exogenous application of BRs to improve stress tolerance in plants has recently become a high research priority. Several studies have revealed the involvement of these steroidal hormones in upregulation of stress-related defense genes and their cross talk with other metabolic pathways. This is likely to stimulate research on many unanswered questions regarding their role in enhancing the ability of plants to tolerate adverse environmental conditions...
May 24, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28538315/evaluation-of-the-effectiveness-of-compression-garments-on-autonomic-nervous-system-recovery-after-exercise
#3
Alessandro Piras, Giorgio Gatta
Piras, A and Gatta, G. Evaluation of the effectiveness of compression garments on autonomic nervous system recovery after exercise. J Strength Cond Res 31(6): 1636-1643, 2017-The aim of this investigation was to evaluate the recovery pattern of a whole-body compression garment on hemodynamic parameters and on autonomic nervous system (ANS) activity after a swimming performance. Ten young male athletes were recruited and tested in 2 different days, with and without wearing the garment during the recovery phase...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28528724/twelve-lead-ambulatory-electrocardiographic-monitoring-in-brugada-syndrome-potential-diagnostic-and-prognostic-implications
#4
Belinda Gray, Adrienne Kirby, Peter Kabunga, Saul B Freedman, Laura Yeates, Ajita Kanthan, Caroline Medi, Anthony Keech, Christopher Semsarian, Raymond W Sy
BACKGROUND: Patients with Brugada syndrome (BrS) are diagnosed and risk stratified on the basis of a spontaneous or drug-induced type 1 electrocardiographic (ECG) pattern, often at single time points not accounting for variation throughout the day. OBJECTIVES: The purpose of this study was to prospectively assess the overall burden of type 1 Brugada ECG changes using 12-lead 24-hour Holter monitoring and evaluate association with cardiac events. METHODS: From July 1, 2013 to December 31, 2015, patients with BrS were recruited from 3 Australian centers and the Australian Genetic Heart Disease Registry...
June 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28523371/impact-of-electrocardiogram-screening-during-drug-challenge-test-for-the-prediction-of-t-wave-oversensing-by-a-subcutaneous-implantable-cardioverter-defibrillator-in-patients-with-brugada-syndrome
#5
Tsukasa Kamakura, Mitsuru Wada, Kohei Ishibashi, Yuko Y Inoue, Koji Miyamoto, Hideo Okamura, Satoshi Nagase, Takashi Noda, Takeshi Aiba, Satoshi Yasuda, Kengo Kusano
Screening tests conducted at rest may be inadequate for the prediction of the T-wave oversensing (TWOS) in subcutaneous implantable cardioverter defibrillator (S-ICD) candidates with Brugada syndrome (BrS) because of the dynamic nature of electrocardiogram (ECG) morphology. We evaluated the utility of ECG screening during drug challenge (DC) for prediction of TWOS in BrS patients implanted with an S-ICD. The study enrolled 6 consecutive BrS patients implanted with an S-ICD. In addition to baseline ECG screening, pre-implant screening during DC using a sodium channel blocker was performed in all patients...
May 18, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28516384/a-mutant-in-the-csdet2-gene-leads-to-a-systemic-brassinosteriod-deficiency-and-super-compact-phenotype-in-cucumber-cucumis-sativus-l
#6
Shanshan Hou, Huanhuan Niu, Qianyi Tao, Shenhao Wang, Zhenhui Gong, Sen Li, Yiqun Weng, Zheng Li
A novel dwarf cucumber mutant, scp-2, displays a typical BR biosynthesis-deficient phenotype, which is due to a mutation in CsDET2 for a steroid 5-alpha-reductase. Brassinosteroids (BRs) are a group of plant hormones that play important roles in the development of plant architecture, and extreme dwarfism is a typical outcome of BR-deficiency. Most cucumber (Cucumis sativus L.) varieties have an indeterminate growth habit, and dwarfism may have its value in manipulation of plant architecture and improve production in certain production systems...
May 17, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28507603/fingolimod-initiation-in-multiple-sclerosis-patients-is-associated-with-potential-beneficial-cardiovascular-autonomic-effects
#7
Max J Hilz, Ruihao Wang, Carmen de Rojas Leal, Mao Liu, Francesca Canavese, Sankanika Roy, Katharina M Hösl, Klemens Winder, De-Hyung Lee, Ralf A Linker
BACKGROUND: Fingolimod slows heart rate (HR) due to vagomimetic effects and might cause additional cardiovascular autonomic changes. While the time course of HR changes is well described, the extent and course of cardiovascular autonomic changes upon fingolimod initiation has not yet been evaluated. This study, therefore, intended to assess cardiovascular autonomic changes during the first 6 h after fingolimod initiation. METHODS: In 21 patients with relapsing-remitting multiple sclerosis (RRMS), we recorded respiration (RESP), electrocardiographic RR interval (RRI), systolic and diastolic blood pressure (BPsys, BPdia) at rest, before and 0...
April 2017: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/28507175/a-mutation-in-the-bhlh-domain-of-the-spch-transcription-factor-uncovers-a-br-dependent-mechanism-for-stomatal-development
#8
Alberto de Marcos, Anaxi Houbaert, Magdalena Triviño, Dolores Delgado, Mar Martín-Trillo, Eugenia Russinova, Carmen Fenoll, Montaña Mena
The asymmetric cell divisions necessary for stomatal lineage initiation and progression in Arabidopsis thaliana require the function of the basic helix-loop-helix (bHLH) transcription factor SPEECHLESS (SPCH). Mutants lacking SPCH do not produce stomata or lineages. Here, we isolated a new spch 5 allele carrying a point mutation in the bHLH domain that displayed normal growth, but had an extremely low number of sometimes clustered stomata in the leaves, whereas the hypocotyls were stomataless. In vivo tracking of leaf epidermal cell divisions, combined with marker lines and genetic analysis, showed that the spch 5 leaf phenotype is dosage dependent and results from the decreased ability to initiate and amplify lineages, defects in asymmetric cell fate allocation, and misorientation of asymmetric division planes...
May 15, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28504223/belgium-coronary-and-structural-heart-interventions-from-2010-to-2015
#9
Walter Desmet, Adel Aminian, Joëlle Kefer, Joseph Dens, Johan Bosmans, Marc Claeys, Christophe Dubois, Olivier Gach, Luc Janssens, Erwin Schroeder, Paul Vermeersch, Marc Carlier, Edouard Benit, Claude Hanet
In a ranking of the gross domestic product per capita in 2015, Belgium ranked 19th in the world according to the International Monetary Fun1d and the World Bank. It has a Human Development Index of 0.890, in which it is preceded by only 20 other countries in the world. This is, at least in part, due to a well-developed social security system on which all citizens can rely. Over the last 5-10 years, however, this system has come under increasing pressure. This has resulted in insufficient, incomplete and late reimbursement of all technologies that were introduced over the last ten years in the cathlab: intracoronary imaging techniques are not reimbursed at all, and FFR only to a vastly insufficient degree...
May 15, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28504218/first-in-human-evaluation-of-a-novel-poly-l-lactide-based-sirolimus-eluting-bioresorbable-vascular-scaffold-for-the-treatment-of-de-novo-native-coronary-artery-lesions-meres-1-trial
#10
Ashok Seth, Yoshinobu Onuma, Ricardo Costa, Praveen Chandra, Vinay K Bahl, Cholenahally N Manjunath, Ajaykumar U Mahajan, Viveka Kumar, Pravin K Goel, Gurpreet S Wander, Mathew S Kalarickal, Upendra Kaul, V K Ajit Kumar, Pratap C Rath, Vijay Trehan, Gunasekaran Sengottuvelu, Sundeep Mishra, Alexandre Abizaid, Patrick W Serruys
AIMS: The MeRes-1 trial sought to study the safety and effectiveness of a novel sirolimus-eluting bioresorbable vascular scaffold (MeRes100 BRS) in treating de novo native coronary artery lesions by clinical evaluation and using multiple imaging modalities. METHODS AND RESULTS: The MeRes-1 first-in-human trial was a single-arm, prospective, multicentre study, which enrolled 108 patients with de novo coronary artery lesions (116 scaffolds were deployed to treat 116 lesions in 108 patients)...
May 16, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28503726/baroreflex-dysfunction-and-augmented-sympathetic-nerve-responses-during-mental-stress-in-veterans-with-posttraumatic-stress-disorder-ptsd
#11
Jeanie Park, Paul J Marvar, Peizhou Liao, Melanie L Kankam, Seth D Norrholm, Ryan M Downey, S Ashley McCullough, Ngoc-Anh Le, Barbara O Rothbaum
Posttraumatic Stress Disorder (PTSD) is associated with increased cardiovascular (CV) risk. We tested the hypothesis that PTSD patients have augmented sympathetic nervous system (SNS) and hemodynamic reactivity during mental stress, and impaired arterial baroreflex sensitivity (BRS). 14 otherwise healthy Veterans with combat-related PTSD were compared to 14 matched Controls without PTSD.  Muscle sympathetic nerve activity (MSNA), continuous blood pressure (BP), and electrocardiography were measured at baseline, and during two types of mental stress:  combat-related mental stress using virtual reality combat exposure (VRCE); and noncombat related stress using mental arithmetic (MA)...
May 14, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28502860/structure-activity-relationship-of-brassinosteroids-and-their-agricultural-practical-usages
#12
REVIEW
Jinna Liu, Di Zhang, Xiaoyu Sun, Tingle Ding, Beilei Lei, Cunli Zhang
Brassinosteroids (BRs) control several important agronomic traits, such as strengthening resistance to diverse adversity, improving the quality, and increasing crop yield. Their chemical structures and varieties, specific methods for the evaluation of bioactivities, structure-activity relationships, potential novel compounds, and practical agricultural uses were summarized. The findings allow the examination of brassinosteriods in two important issues: 1) Do the results of different bioevaluation protocols provide similar activities for BRs? And 2) which bioevaluated compounds would proof to have a greater potential for application in agricultural usages?...
May 11, 2017: Steroids
https://www.readbyqxmd.com/read/28502737/gel-free-label-free-proteomic-photosynthetic-and-biochemical-analysis-of-cowpea-vigna-unguiculata-l-walp-resistance-against-cowpea-severe-mosaic-virus-cpsmv
#13
Anna Lidia N Varela, Setsuko Komatsu, Xin Wang, Rodolpho G G Silva, Pedro Filho N Souza, Ana Karla M Lobo, Ilka M Vasconcelos, Joaquim A G Silveira, Jose T A Oliveira
Cowpea severe mosaic virus (CPSMV) causes significant losses in cowpea (Vigna unguiculata) production. In this present study biochemical, physiological, and proteomic analysis were done to identify pathways and defense proteins that are altered during the incompatible interaction between the cowpea genotype BRS-Marataoã and CPSMV. The leaf protein extracts from mock- (MI) and CPSMV-inoculated plantlets (V) were evaluated at 2 and 6days post-inoculation (DPI). Data support the assumptions that increases in biochemical (high hydrogen peroxide, antioxidant enzymes, and secondary compounds) and physiological responses (high photosynthesis index and chlorophyll content), confirmed by label-free comparative proteomic approach, in which quantitative changes in proteasome proteins, proteins related to photosynthesis, redox homeostasis, regulation factors/RNA processing proteins were observed may be implicated in the resistance of BRS-Marataoã to CPSMV...
May 11, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28501193/immunoaffinity-chromatography-combined-with-tandem-mass-spectrometry-a-new-tool-for-the-selective-capture-and-analysis-of-brassinosteroid-plant-hormones
#14
Jana Oklestkova, Danuše Tarkowská, Luděk Eyer, Tomáš Elbert, Aleš Marek, Zora Smržová, Ondřej Novák, Milan Fránek, Vladimir N Zhabinskii, Miroslav Strnad
Brassinosteroids (BRs) are plant-specific steroid hormones that play essential roles in the regulation of many important physiological processes in plant life. Their extremely low concentrations (~pmoles/g FW) in plant tissue and huge differences in polarity of individual members within the BR family hamper their detection and quantification. To address this problem, an immunoaffinity sorbent with broad specificity and high capacity for different BR metabolites containing a monoclonal antibody (mAb) against a BR spacer (20S)-2α,3α-dihydroxy-7-oxa-7α-homo-5α-pregnane-6-one-20 carboxylic acid (BR4812) was used for the rapid and highly selective isolation of endogenous BRs containing a 2α,3α-diol in ring A from minute plant samples...
August 1, 2017: Talanta
https://www.readbyqxmd.com/read/28500288/light-perception-in-aerial-tissues-enhances-dwf4-accumulation-in-root-tips-and-induces-root-growth
#15
Jun Sakaguchi, Yuichiro Watanabe
Many attempts have been made to characterize the activities of brassinosteroids (BRs), which are important plant hormones. The crosstalk between light perception and the BR signalling pathway has been extensively studied regarding its effects on photomorphogenesis, especially in elongating etiolated hypocotyls. In contrast, how and where the light induces BR biosynthesis remain uncharacterized. DWF4 is one of the main enzymes involved in the BR biosynthesis pathway in Arabidopsis thaliana. We established DWF4-GUS A...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28497338/decreased-spontaneous-baroreflex-sensitivity-as-an-early-marker-for-progression-of-haemorrhage
#16
Kavita Yadav, Akanksha Singh, Smriti Badhwar, Ashok Kumar Jaryal, Poonam Coshic, Kabita Chatterjee, K K Deepak
INTRODUCTION: Blood donation provides an ideal setup for assessment of cardiovascular responses to mild hypovolemia for understanding the underlying mechanisms. AIM: To evaluate cardiovascular responses in time and magnitude by estimating the spontaneous baroreflex sensitivity (BRS) during and after donation of 450 ml of blood. METHODS: Continuous beat-to-beat blood pressure and lead II ECG was recorded before, during and after blood donation in 54 healthy volunteers (age 34...
May 11, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/28496938/brugada-syndrome-risk-stratification-and-management
#17
REVIEW
Yoshifusa Aizawa
The Brugada syndrome (BrS) is an arrhythmogenic disease associated with an increased risk of ventricular fibrillation and sudden cardiac death. The risk stratification and management of BrS patients, particularly of asymptomatic ones, still remains challenging. A previous history of aborted sudden cardiac death or arrhythmic syncope in the presence of spontaneous type 1 ECG pattern of BrS phenotype appear to be the most reliable predictors of future arrhythmic events. Several other ECG parameters have been proposed for risk stratification...
October 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/28486839/brugada-syndrome-and-the-story-of-dave
#18
Samira Kashinath Dhamapurkar, Barbara A Wilson, Anita Rose, Gerhard Florschutz
Brugada syndrome (BrS) is a little known genetic condition that causes severe disturbances in cardiac rhythm and may result in sudden unexpected cardiac death in an apparently healthy person. The heart structure is typically normal but there are problems with electrical activity. The syndrome is named after Spanish brothers who are cardiologists, Pedro and Josep Brugada. BrS is the major cause of sudden unexplained death syndrome (SUDS), also known as sudden arrhythmic death syndrome (SADS). Following a description of the syndrome, including its prevalence and incidence, how it is diagnosed and how it can be treated, we consider those who survive a cardiac arrest and what problems they may face...
May 10, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28485268/biochemical-studies-of-amylase-lipase-and-protease-in-callosobruchus-maculatus-coleoptera-chrysomelidae-populations-fed-with-vigna-unguiculata-grain-cultivated-with-diazotrophic-bacteria-strains
#19
L B Silva, É B Torres, R A S Nóbrega, G N Lopes, R F Vogado, B E Pavan, P I Fernandes-Junior
The objective of this study was to evaluate the enzymatic activity of homogenates of insects fed on grain of cowpea, Vigna unguiculata (L.), cultivars grown with different nitrogen sources. For the experiment we used aliquots of the homogenate of 100 unsexed adult insects, emerged from 10 g of grain obtained from four cowpea cultivars: 'BRS Acauã', 'BRS Carijó', 'BRS Pujante', and 'BRS Tapaihum' grown under different regimes of nitrogen sources: mineral fertilizer, inoculation with strains of diazotrophs (BR 3267, BR 3262, BR 3299; INPA 03-11B, 03-84 UFLA, as well as the control (with soil nitrogen)...
May 9, 2017: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/28479230/characterization-of-synthetic-ecdysteroid-analogues-as-functional-mimics-of-brassinosteroids-in-plant-growth
#20
Jutiporn Thussagunpanit, Kanapol Jutamanee, Sureeporn Homvisasevongsa, Apichart Suksamrarn, Ayumi Yamagami, Takeshi Nakano, Tadao Asami
Brassinosteroids (BRs) are plant steroidal hormones that play important roles in many stages of plant growth. Several plant species produce ecdysteroids, which are known as insect molting steroid hormones. In this study, we evaluated the biological activities of three hydroxysteroidal compounds, 20-hydroxyecdysone (ECD), 7,8-dihydro-8α-20-hydroxyecdysone (DHECD), and 7,8-dihydro-5a,8a-20-hydroxyecdysone (a-DHECD), and compared their activities with that of brassinolide (BL), the most potent BR. In rice, DHECD and a-DHECD enhanced the degree of lamina inclination, as do BRs...
May 4, 2017: Journal of Steroid Biochemistry and Molecular Biology
keyword
keyword
52050
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"