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https://www.readbyqxmd.com/read/28107741/building-related-symptoms-are-linked-to-the-in-vitro-toxicity-of-indoor-dust-and-airborne-microbial-propagules-in-schools-a-cross-sectional-study
#1
J T Salin, M Salkinoja-Salonen, P J Salin, K Nelo, T Holma, P Ohtonen, H Syrjälä
INTRODUCTION: Indoor microbial toxicity is suspected to cause some building-related symptoms, but supporting epidemiological data are lacking. OBJECTIVE: We examined whether the in vitro toxicity of indoor samples from school buildings was associated with work-related health symptoms (building-related symptoms, BRS). METHODS: Administrators of the Helsinki City Real Estate Department selected 15 schools for the study, and a questionnaire on symptoms connected to work was sent to the teachers in the selected schools for voluntary completion...
January 17, 2017: Environmental Research
https://www.readbyqxmd.com/read/28102901/risk-of-arrhythmic-death-in-ischemic-heart-disease-a-prospective-controlled-observer-blind-investigation-over-10-years
#2
Thomas Pezawas, André Diedrich, David Robertson, Robert Winker, Bernhard Richter, Li Wang, Herwig Schmidinger
BACKGROUND: Risk of arrhythmic death is considered highest in ischemic heart disease with severe left ventricular ejection fraction (LVEF) reduction. Non-invasive testing should improve decision-making of prophylactic defibrillator (ICD) implantation. METHODS AND RESULTS: We enrolled 120 patients with ischemic heart disease and LVEF <50% and 30 control subjects without ischemic heart disease and normal LVEF. An initial assessment, a second assessment after 3 years, and a final follow-up comprised of: pharmacological baroreflex testing (BRS), short-term spectral (low frequency (LF) to high frequency (HF) ratio) and long-term time domain analysis of heart rate variability (SDNN), exercise Microvolt T-wave alternans (MTWA) and others...
January 19, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28100707/the-rla1-smos1-transcription-factor-functions-with-osbzr1-to-regulate-brassinosteroid-signaling-and-rice-architecture
#3
Shenglong Qiao, Shiyong Sun, Linlin Wang, Zhihua Wu, Chengxiang Li, Xiaoming Li, Tao Wang, Linna Leng, Weisheng Tian, Tiegang Lu, Xuelu Wang
Brassinosteroids (BRs) are plant-specific steroid hormones that control plant growth and development. Recent studies have identified key components of the BR signaling pathway in Arabidopsis thaliana and in rice (Oryza sativa); however, the mechanism of BR signaling in rice, especially downstream of GSK3/SHAGGY-like kinase (GSK2), remains unclear. Here we identified a BR-insensitive rice mutant, reduced leaf angle 1 (rla1), and cloned the corresponding gene. RLA1 was identical to the previously reported SMALL ORGAN SIZE 1 (SMOS1) which was cloned from another allele...
January 18, 2017: Plant Cell
https://www.readbyqxmd.com/read/28096215/brassinosteroid-signaling-directs-formative-cell-divisions-and-protophloem-differentiation-in-arabidopsis-root-meristems
#4
Yeon Hee Kang, Alice Breda, Christian S Hardtke
Brassinosteroids (BRs) trigger an intracellular signaling cascade through its receptors BR INSENSITIVE 1 (BRI1), BRI1-LIKE 1 (BRL1) and BRL3. Recent studies suggest that BR-independent inputs related to vascular differentiation, for instance root protophloem development, modulate downstream BR signaling components. Here, we report that protophloem sieve element differentiation is indeed impaired in bri1 brl1 brl3 mutants, although this effect might not be mediated by canonical downstream BR signaling components...
January 15, 2017: Development
https://www.readbyqxmd.com/read/28079533/national-and-regional-differences-in-32-248-postmastectomy-autologous-breast-reconstruction-using-the-updated-national-inpatient-survey
#5
Parisa Kamali, Marek A Paul, Ahmed M S Ibrahim, Pieter G L Koolen, Winona Wu, Marc L Schermerhorn, Bernard T Lee, Samuel J Lin
BACKGROUND: The incidence of breast cancer (BC) cases has increased significantly. The number of breast reconstruction (BR) procedures performed has mirrored this trend. Although implant-only procedures remain the most commonly used type of immediate BR, autologous techniques involving donor sites account for approximately 20%. The aim of this study was to assess national and regional trends in different types of autologous BR. METHODS: Using the Nationwide Inpatient Sample database (2008 to 2012), data on BC and mastectomy rates, type of autologous BR, and sociodemographics were obtained and analyzed...
January 10, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28077816/incidence-of-atrial-tachyarrhythmias-in-patients-with-early-repolarization-syndrome
#6
Ki Won Hwang, Gi-Byoung Nam, Junhee Han, Yong Giun Kim, Hyung Oh Choi, Jun Kim, Kee-Joon Choi, You-Ho Kim
Atrial tachyarrhythmias (ATAs) occur in a significant proportion of Brugada syndrome (BrS) patients and are often an important cause of inappropriate shocks. The aim of this retrospective study was to evaluate the incidence of ATAs and ATA-induced inappropriate shocks in early repolarization syndrome (ERS) patients as compared to BrS patients.We analyzed data from 20 consecutive patients who were diagnosed with ERS and compared them with patients diagnosed with BrS (n = 31). Clinical and ICD interrogation data were collected and analyzed for all events with ICD shocks...
January 11, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28075709/the-influence-of-exercise-intensity-on-postexercise-baroreflex-sensitivity
#7
Linda J Reynolds, Mark B A De Ste Croix, David V B James
PURPOSE: The purpose of this study was to investigate the influence of exercise intensity on postexercise supine and tilt baroreflex sensitivity (BRS). METHOD: Nine healthy, active men performed 2 conditions of interval cycling of 40% maximal work rate (WRmax) and 75% WRmax of matched work done and a control condition of no exercise in a counterbalanced order. BRS outcome measures were determined at preexercise and postexercise up to +24 hr in supine and tilt positions...
January 11, 2017: Research Quarterly for Exercise and Sport
https://www.readbyqxmd.com/read/28069895/brassinosteroid-induced-transcriptional-repression-and-dephosphorylation-dependent-protein-degradation-negatively-regulate-bin2-interacting-aif2-a-br-signaling-negative-regulator-bhlh-transcription-factor
#8
Yoon Kim, Ji-Hye Song, Seon-U Park, You-Seung Jeong, Soo-Hwan Kim
Brassinosteroids (BRs) are plant polyhydroxy-steroids that play important roles in plant growth and development via extensive signal integration through direct interactions between regulatory components of different signaling pathways. Recent studies have shown that diverse helix-loop-helix/basic helix-loop-helix (HLH/bHLH) family proteins are actively involved in control of BR signaling pathways and interact with other signaling pathways. In this study, we show that ATBS1-INTERACTING FACTOR 2 (AIF2), a nuclear-localized atypical bHLH transcription factor, specifically interacts with BRASSINOSTEROID-INSENSITIVE 2 (BIN2) among other BR-signaling molecules...
January 9, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28068465/one-year-developmental-outcomes-for-infants-of-mothers-with-bipolar-disorder
#9
Aimee K Santucci, Lynn T Singer, Stephen R Wisniewski, James F Luther, Heather F Eng, Dorothy K Sit, Katherine L Wisner
OBJECTIVE: Few data about the development of infants born to women with bipolar disorder have been published. We hypothesized that infants of women with bipolar disorder (by DSM-IV criteria) treated with psychotropics (BD+) or untreated with psychotropics (BD-) would demonstrate poorer cognitive and behavioral development than infants of controls. On the basis of previous studies, we expected that psychotropic-exposed infants of women in the BD+ group would have poorer neuromotor performance during infancy...
January 3, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28068072/stacking-interactions-induced-selective-conformation-of-discrete-ar-omatic-arrays-and-borromean-rings
#10
Long Zhang, Lin Lin, Dong Liu, Yue-Jian Lin, Zhen-Hua Li, Guo-Xin Jin
Herein, we describe how to utilize stacking interactions to achieve selective supramolecular transfor-mation and molecular Borromean rings (BRs). By using a dinuclear NDI-based Cp*Rh acceptor and linear bipyridyl ligands, organometallic rectangles featuring dynamic behavior have been constructed. Unique discrete aromatic stack-ing arrays were formed by inducing pyrene units as guest molecules. The topology of the BRs was realized by the use of a strategically chosen ligand which was capable of participating in D-A interactions and hydrogen bonding, as evi-denced from single-crystal X-ray analysis and computational studies...
January 9, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28065832/a-novel-method-to-enhance-phenotype-epicardial-functional-substrates-and-ventricular-tachyarrhythmias-in-brugada-syndrome
#11
Fa-Po Chung, Sunu Budhi Raharjo, Yenn-Jiang Lin, Shih-Lin Chang, Li-Wei Lo, Yu-Feng Hu, Ta-Chuan Tuan, Tze-Fan Chao, Jo-Nan Liao, Chin-Yu Lin, Yao-Ting Chang, Yuan Hung, Abigail Te, Shinya Yamada, Hiroshi Tasaka, Shih-Ann Chen, Chin-Tien Wang
BACKGROUND: Fever is associated with the manifestation of Brugada phenotype and ventricular tachycardia/fibrillation (VT/VF) in patients with Brugada syndrome (BrS). The thermal effect on the pathogenesis of functional substrates in BrS remains unknown. OBJECTIVE: The study aimed to elucidate the thermal effect on BrS phenotype, VT/VF, and electrophysiological characteristics of epicardial functional substrates in BrS. METHODS: We consecutively studied 15 patients with BrS receiving radiofrequency catheter ablation (RFCA) for drug-refractory ventricular tachyarrhythmias...
January 5, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28062207/cardiometabolic-biomarkers-are-predictors-of-readmission-and-death-in-patients-hospitalized-for-acute-dyspnea
#12
Nathalie Lund, Klas Gränsbo, Camilla Wernersson, Olle Melander
BACKGROUND: Acute dyspnea affects a large heterogeneous patient group with high mortality and readmission rates. PURPOSE: To investigate if cardiometabolic biomarkers and clinical characteristics predict readmission and death in patients hospitalized for acute dyspnea. METHODS: 65 dyspnea patients at a general internal medicine ward were followed for six months. The combined endpoint was readmission or death. MEASUREMENTS AND RESULTS: Cardiometabolic biomarkers at admission were related to the endpoint in Cox proportional hazard models (adjusted for sex, age, oxygen saturation, respiratory rate and C-reactive protein (CRP))...
December 22, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28061864/identification-of-brassinosteroid-genes-in-brachypodium-distachyon
#13
Claudia Corvalán, Sunghwa Choe
BACKGROUND: Brassinosteroids (BRs) are steroidal phytohormones that are involved in diverse physiological processes and affect many important traits, such as plant stature, stress tolerance, leaf angle, fertility, and grain filling. BR signaling and biosynthetic pathways have been studied in various plants, such as the model dicot Arabidopsis thaliana; however, relatively little is known about these pathways in monocots. RESULTS: To characterize BR-related processes in the model grass Brachypodium distachyon, we studied the response of these plants to the specific BR biosynthesis inhibitor, propiconazole (Pcz)...
January 6, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28060537/variations-of-perioperative-baroreflex-sensitivity-in-hypertensive-and-normotensive-patients
#14
Dan Huang, Jie Zhou, Diansan Su, Weifeng Yu, Jie Chen
BACKGROUND: Impaired baroreflex sensitivity (BRS) is a marker of autonomous dysfunction, which may play an important role in the long-term development of hypertension. Perioperative patients with hypertension are rapidly increasing in all populations worldwide. OBJECTIVE: To estimate the value of BRS for hypertension in a surgery cohort. METHODS: An observational and cross-sectional study was performed, involving 96 patients who underwent video-assisted thoracoscopic pulmonary lobectomy or segmentectomy...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28057327/occurrence-of-brassinosteroids-in-non-flowering-land-plants-liverwort-moss-lycophyte-and-fern
#15
Takao Yokota, Toshiyuki Ohnishi, Kyomi Shibata, Masashi Asahina, Takahito Nomura, Tomomichi Fujita, Kimitsune Ishizaki, Takayuki Kohchi
Endogenous brassinosteroids (BRs) in non-flowering land plants were analyzed. BRs were found in a liverwort (Marchantia polymorpha), a moss (Physcomitrella patens), lycophytes (Selaginella moellendorffii and S. uncinata) and 13 fern species. A biologically active BR, castasterone (CS), was identified in most of these non-flowering plants but another biologically active BR, brassinolide, was not. It may be distinctive that levels of CS in non-flowering plants were orders of magnitude lower than those in flowering plants...
January 2, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28043809/physical-training-associated-with-enalapril-but-not-to-losartan-results-in-better-cardiovascular-autonomic-effects
#16
Karina Delgado Maida, Ada Clarice Gastaldi, Tabata de Paula Facioli, João Eduardo de Araújo, Hugo Celso Dutra de Souza
BACKGROUND: We investigated the cardiovascular autonomic effects of physical training associated with Enalapril or Losartan pharmacological treatments in spontaneously hypertensive rats (SHR). METHODS: SHRs, 18weeks of age (N=48) was assigned to either sedentary (N=24) and trained (N=24; aerobic training by swimming for 10wk). Each group was subdivided in 3 subgroups (N=8) vehicle (control); Enalapril (10mg·kg(-1)·d(-1)); and Losartan (5mg·kg(-1)·d(-1)). All animals received a 10-week treatment in drinking water...
December 24, 2016: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28039591/visualizing-polymeric-bioresorbable-scaffolds-with-three-dimensional-image-reconstruction-using-contrast-enhanced-micro-computed-tomography
#17
Sheng Tu, Fudong Hu, Wei Cai, Liyan Xiao, Linlin Zhang, Hong Zheng, Qiong Jiang, Lianglong Chen
There are no previous studies showing how to visualize polymeric bioresorbable scaffolds (BRSs) by micro-computed tomography (mCT). There are no previous studies showing how to visualize polymeric bioresorbable scaffolds (BRSs) by micro-computed tomography (mCT). This study aimed to explore the feasibility of detecting polymeric BRS with 3-dimensional reconstruction of BRS images by contrast-enhanced mCT and to determine the optimal imaging settings. BRSs, made of poly-L-lactic acid (PLLA), were implanted in coronary bifurcation models...
December 30, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28035023/related-to-abi3-vp1-like-1-ravl1-regulates-brassinosteroid-mediated-activation-of-amt1-2-in-rice-oryza-sativa
#18
Yuan Hu Xuan, Feng Ying Duan, Byoung Il Je, Chul Min Kim, Tian Ya Li, Jing Miao Liu, Soon Ju Park, Jun Hyeon Cho, Tae Ho Kim, Nicolaus von Wiren, Chang-Deok Han
The promotive effects of brassinosteroids (BRs) on plant growth and development have been widely investigated; however, it is not known whether BRs directly affect nutrient uptake. Here, we explored the possibility of a direct relationship between BRs and ammonium uptake via AMT1-type genes in rice (Oryza sativa). BR treatment increased the expression of AMT1;1 and AMT1;2, whereas in the mutant d61-1, which is defective in the BR-receptor gene BRI1, BR-dependent expression of these genes was suppressed. We then employed Related to ABI3/VP1-Like 1 (RAVL1), which is involved in BR homeostasis, to investigate BR-mediated AMT1 expression and its effect on NH4(+) uptake in rice roots...
December 29, 2016: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28032995/comprehensive-profiling-of-phytohormones-in-honey-by-sequential-liquid-liquid-extraction-coupled-with-liquid-chromatography-mass-spectrometry
#19
Qing Wang, Wen-Jing Cai, Lei Yu, Jun Ding, Yu-Qi Feng
Honey exhibits various nutritional and medicinal functions, which are highly related to the active components, thus the exploration of new compounds in honey is of great importance. As honey is a by-product of flower nectar, which is rich in phytohormones, the existence of phytohormones in honeys is anticipated. In this research, a method for comprehensive profiling of 49 phytohormones in honey was developed by sequential liquid-liquid extraction (LLE) coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
December 29, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28032242/molecular-pathological-study-on-lrrc10-in-sudden-unexplained-nocturnal-death-syndrome-in-the-chinese-han-population
#20
Lei Huang, Shuangbo Tang, Yili Chen, Liyong Zhang, Kun Yin, Yeda Wu, Jinxiang Zheng, Qiuping Wu, Jonathan C Makielski, Jianding Cheng
Sudden unexplained nocturnal death syndrome (SUNDS) is a perplexing disorder to both forensic pathologists and clinic physicians. Clinical features of SUNDS survivors suggested that SUNDS is similar to Brugada syndrome (BrS). Leucine-rich repeat containing 10 (LRRC10) gene was a newly identified gene linked to dilated cardiomyopathy, a disease associated with sudden cardiac death. To investigate the prevalence and spectrum of genetic variants of LRRC10 gene in SUNDS and BrS, the coding regions of LRRC10 were genetically screened in 113 sporadic SUNDS victims (from January 2005 to December 2015, 30...
December 28, 2016: International Journal of Legal Medicine
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