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https://www.readbyqxmd.com/read/29028796/bak1-is-involved-in-atralf1-induced-inhibition-of-root-cell-expansion
#1
Keini Dressano, Paulo H O Ceciliato, Aparecida L Silva, Juan Carlos Guerrero-Abad, Tábata Bergonci, Fausto Andrés Ortiz-Morea, Marco Bürger, Marcio C Silva-Filho, Daniel S Moura
The rapid alkalinization factor (RALF) peptide negatively regulates cell expansion, and an antagonistic relationship has been demonstrated between AtRALF1, a root-specific RALF isoform in Arabidopsis, and brassinosteroids (BRs). An evaluation of the response of BR signaling mutants to AtRALF1 revealed that BRI1-associated receptor kinase1 (bak1) mutants are insensitive to AtRALF1 root growth inhibition activity. BAK1 was essential for the induction of AtRALF1-responsive genes but showed no effect on the mobilization of Ca2+ and alkalinization responses...
October 13, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29027842/wrky-transcription-factors-are-involved-in-brassinosteroid-signaling-and-mediate-the-crosstalk-between-plant-growth-and-drought-tolerance
#2
Jiani Chen, Yanhai Yin
Brassinosteroids (BRs) are critical for the plant growth and development. BRs signal through the plasma membrane localized receptor-like kinases to downstream transcription factors BES1/BZR1 to regulate the expression of thousands of genes for various BR responses. In addition to the role in plant growth and development, BRs have been implicated in responses to environmental stresses such as drought. However, the mechanism through which BRs regulate drought have just begun emerging. We have recently found that a group of WRKY transcription factors, WRKY46, WRKY54, WRKY70, which are well known for the function in abiotic and biotic stress, cooperates with BES1 to mediate BR-regulated drought response...
October 13, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/29025556/patients-with-brugada-syndrome-and-implanted-cardioverter-defibrillators-long-term-follow-up
#3
Jaime Hernandez-Ojeda, Elena Arbelo, Roger Borras, Paola Berne, Jose M Tolosana, Andrea Gomez-Juanatey, Antonio Berruezo, Oscar Campuzano, Georgia Sarquella-Brugada, Lluis Mont, Ramon Brugada, Josep Brugada
BACKGROUND: Implantable cardioverter-defibrillator (ICD) indications for primary prevention in Brugada syndrome (BrS) are still debated. OBJECTIVES: The authors investigated the long-term outcome after ICD implantation in a large cohort of BrS patients. METHODS: Of a total of 370 patients with BrS in follow-up (age 43 ± 14 years; 74% male), 104 patients (28.1%) were treated with ICDs. The authors analyzed the long-term incidence of shocks and complications...
October 17, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29023796/hemodynamic-parameters-and-baroreflex-sensitivity-during-head-up-tilt-test-in-patients-with-neurally-mediated-syncope
#4
Sung Ho Lee, Ji Hyun Yang, Hye Ran Yim, Jungwae Park, Seung-Jung Park, Kyoung-Min Park, Young Keun On, June Soo Kim
BACKGROUND: We aimed to investigate differences in hemodynamic parameters and the role of baroreflex sensitivity (BRS) in patients with a history of neurally mediated syncope (NMS) compared with a control group. METHODS: Hemodynamic parameters and BRS were continuously measured non-invasively using a Finometer at rest and during passive head-up tilt test (HUT) in patients with a history of NMS (n = 55) and a control group (n = 77). The tilting period was divided into pretest (resting supine position), initial (first 3 minutes of tilting), last (last 3 minutes of tilting), and recovery (3 minutes after tilting was complete) periods...
October 10, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29021808/brassinosteroids-regulate-ofp1-a-dlt-interacting-protein-to-modulate-plant-architecture-and-grain-morphology-in-rice
#5
Yunhua Xiao, Dapu Liu, Guoxia Zhang, Hongning Tong, Chengcai Chu
Brassinosteroids (BRs) regulate important agronomic traits in rice, including plant height, leaf angle, and grain size. However, the underlying mechanisms remain not fully understood. We previously showed that GSK2, the central negative regulator of BR signaling, targets DLT, the GRAS family protein, to regulate BR responses. Here, we identified Ovate Family Protein 1 (OFP1) as a DLT interacting protein. OFP1 was ubiquitously expressed and the protein was localized in both cytoplasm and nucleus. Overexpression of OFP1 led to enlarged leaf angles, reduced plant height, and altered grain shape, largely resembled DLT overexpression plants...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29020300/impact-of-design-of-coronary-stents-and-length-of-dual-antiplatelet-therapies-on-ischaemic-and-bleeding-events-a-network-meta-analysis-of-64-randomized-controlled-trials-and-102%C3%A2-735-patients
#6
Fabrizio D'Ascenzo, Mario Iannaccone, Gaelle Saint-Hilary, Maurizio Bertaina, Stefanie Schulz-Schüpke, Cheol Wahn Lee, Alaide Chieffo, Gerard Helft, Sebastiano Gili, Umberto Barbero, Giuseppe Biondi Zoccai, Claudio Moretti, Fabrizio Ugo, Maurizio D'Amico, Roberto Garbo, Gregg Stone, Sara Rettegno, Pierluigi Omedè, Federico Conrotto, Christian Templin, Antonio Colombo, Seung-Jung Park, Adnan Kastrati, David Hildick-Smith, Mauro Gasparini, Fiorenzo Gaita
Aims: The differential impact on ischaemic and bleeding events of the type of drug-eluting stent [durable polymer stents [DES] vs. biodegradable polymer stents vs. bioresorbable scaffolds (BRS)] and length of dual antiplatelet therapy (DAPT) remains to be defined. Methods and results: Randomized controlled trials comparing different types of DES and/or DAPT durations were selected. The primary endpoint was Major Adverse Cardiovascular Events (MACE) [a composite of death, myocardial infarction (MI), and target vessel revascularization]...
August 11, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29020259/report-of-an-esc-eapci-task-force-on-the-evaluation-and-use-of-bioresorbable-scaffolds-for-percutaneous-coronary-intervention-executive-summary
#7
Robert A Byrne, Giulio G Stefanini, Davide Capodanno, Yoshinobu Onuma, Andreas Baumbach, Javier Escaned, Michael Haude, Stefan James, Michael Joner, Peter Jüni, Adnan Kastrati, Semih Oktay, William Wijns, Patrick W Serruys, Stephan Windecker
A previous Task Force of the European Society of Cardiology (ESC) and European Association of Percutaneous Cardiovascular Interventions (EAPCI) provided a report on recommendations for the non-clinical and clinical evaluation of coronary stents. Following dialogue with the European Commission, the Task Force was asked to prepare an additional report on the class of devices known as bioresorbable scaffolds (BRS). Five BRS have CE-mark approval for use in Europe. Only one device-the Absorb bioresorbable vascular scaffold-has published randomized clinical trial data and this data show inferior outcomes to conventional drug-eluting stents (DES) at 2-3 years...
August 28, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29016800/the-prognostic-impact-of-single-extra-stimulus-on-programmed-ventricular-stimulation-in-brugada-patients-without-previous-cardiac-arrest-multi-centre-study-in-japan
#8
Masahiko Takagi, Yukio Sekiguchi, Yasuhiro Yokoyama, Naohiko Aihara, Masayasu Hiraoka, Kazutaka Aonuma
Aims: The prognostic value of programmed electrical stimulation (PES) in Brugada syndrome (BrS) remains controversial. One of the reasons for discrepant results may be due to the selection of stimulation protocol. We evaluated the prognostic value of a positive PES result (PES+) according to the inducible pacing sites and the number of extra-stimuli in BrS patients without previous cardiac arrest (CA). Methods and results: We enrolled 224 consecutive BrS patients without previous CA (mean age 51 ± 14 years, 209 males), who underwent PES with the identical protocol...
June 16, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28994463/prognosis-risk-stratification-and-management-of-asymptomatic-individuals-with-brugada-syndrome-a-systematic-review
#9
REVIEW
Konstantinos P Letsas, Dimitrios Asvestas, Adrian Baranchuk, Tong Liu, Stamatis Georgopoulos, Michael Efremidis, Panagiotis Korantzopoulos, George Bazoukis, Gary Tse, Antonios Sideris, Masahiko Takagi, Joachim R Ehrlich
Brugada syndrome (BrS) is a primary electrical disease associated with increased risk of sudden cardiac death due to polymorphic ventricular arrhythmias. The prognosis, risk stratification and management of asymptomatic individuals remain the most controversial issues in BrS. Furthermore, the decision to manage asymptomatic patients with an implantable cardioverter defibrillator should be made after weighing the potential individual risk of future arrhythmic events against the risk of complications associated with the implant and follow-up of patients living with such devices, and the accompanying impairment of the quality of life...
October 10, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28991702/cerebral-autoregulation-is-preserved-in-multiple-sclerosis-patients
#10
Daniel Ferreira, Pedro Castro, Gonçalo Videira, João Pedro Filipe, Rosa Santos, Maria José Sá, Elsa Azevedo, Pedro Abreu
Multiple sclerosis (MS) is an inflammatory disease that may also be associated with vascular dysfunction. One master component of vascular regulation is cerebral autoregulation (CA). We aimed to investigate the integrity of CA in MS patients and study its relationship with autonomic dysfunction (AD), magnetic-resonance-imaging (MRI) lesion load and hemodynamic parameters. We enrolled 20 relapsing-remitting MS and 20 healthy subjects. CA was assessed by transfer function analysis parameters (coherence, gain and phase), as obtained in the very low, low and high-frequency domains (VLF, LF, HF, respectively)...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28980288/novel-and-heteroplasmic-mutations-in-mitochondrial-trna-genes-in-brugada-syndrome
#11
Mahsasadat Fallah Tafti, Mehri Khatami, Shiva Rezaei, Mohammad Mehdi Heidari, Mehdi Hadadzadeh
BACKGROUND: Brugada syndrome (BrS) is a rare cardiac arrhythmia characterized by sudden death associated with electrocardiogram patterns characterized by incomplete right bundle-branch block and ST-segment elevations in the anterior precordial leads. This syndrome predominantly is seen in younger males with structurally normal hearts. Mitochondrial variants particularly mt-tRNA mutations, are hot spots that lead to cardiological disorders. Previous studies have shown that mutations in mitochondrial tRNA genes play an important causal or modifying role in BrS...
October 5, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28973781/diallel-crosses-for-resistance-to-macrophomina-phaseolina-and-thanatephorus-cucumeris-on-cowpea
#12
L R L Lima, K J Damasceno-Silva, M A Noronha, D A Schurt, M M Rocha
This study aimed at identifying and selecting through partial diallel analysis, segregating populations of cowpea resistant to Macrophomina phaseolina and Thanatephorus cucumeris, based on the evaluation of general (GCA) and specific combining ability (SCA), involved in the genetic control of resistance. For this reason, 19 grouped cowpea genotypes, considering the resistance to these pathogens, were crossed in partial diallel scheme 14 x 5, during 2013 and 2014. The 70 F2 populations and the 19 parents were evaluated in a greenhouse as the reaction to pathogens, separately...
September 27, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28973749/genetic-diversity-in-soybean-genotypes-using-phenotypic-characters-and-enzymatic-markers
#13
E V Zambiazzi, A T Bruzi, A P Sales, I M M Borges, S R Guilherme, A M Zuffo, J G Lima, F O Ribeiro, A E S Mendes, S H M Godinho, M L M Carvalho
The objective of this study was to evaluate the genetic diversity of soybean cultivars by adopting phenotypic traits and enzymatic markers, the relative contribution of agronomic traits to diversity, as well as diversity between the level of technology used in soybean cultivars and genetic breeding programs in which cultivars were inserted. The experiments were conducted on the field at the Center for Scientific and Technological Development in crop-livestock production and the Electrophoresis Laboratory of Lavras Federal University...
September 21, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28973745/fertility-restoration-locus-and-cytoplasm-types-in-onion
#14
R R Ferreira, C A F Santos, V R Oliveira
The objective of this study was the identification of the cytoplasmic types and the genotyping for the fertility restoration nuclear locus (Ms) in 59 onion accessions, aiming at the selection of 'A' and 'B' lines essential for the obtainment of hybrids. Three markers were used to identify the cytoplasm 5' cob, orfA501, and orf725, and two were used for the Ms locus (AcSKP1 and AcPMS1). The two types of male-sterile cytoplasm ('S' and 'T'), as well as fertile cytoplasm ('N'), and the Ms and ms alleles in both homozygosity and heterozygosity were detected in the 59 genotypes evaluated in the experiment...
September 21, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28971842/inorganic-nitrate-supplementation-attenuates-peripheral-chemoreflex-sensitivity-but-does-not-improve-cardiovagal-baroreflex-sensitivity-in-older-adults
#15
Joshua M Bock, Kenichi Ueda, Aaron C Schneider, William E Hughes, Jacqueline K Limberg, Nathan S Bryan, Darren P Casey
Aging is associated with increased peripheral chemoreceptor activity, reduced nitric oxide (NO) bioavailability, as well as attenuation of cardiovagal baroreflex sensitivity (BRS), collectively increasing the risk of cardiovascular disease. Evidence suggests NO may attenuate peripheral chemoreflex sensitivity and increase BRS. Exogenous inorganic nitrate increases NO bioavailability via the nitrate-nitrite-nitric oxide pathway. Our hypothesis was that inorganic nitrate supplementation would attenuate peripheral chemoreflex sensitivity and enhance spontaneous cardiovagal BRS in older adults...
September 29, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28969801/the-role-of-brassinosteroids-in-the-regulation-of-the-plasma-membrane-h-atpase-and-nadph-oxidase-under-cadmium-stress
#16
Dagmara Jakubowska, Małgorzata Janicka
The present research aim was to define the role of brassinosteroids (BRs) in plant adaptation to cadmium stress. We observed a stimulating effect of exogenous BR on the activity of two plasma membrane enzymes which play a key role in plants adaptation to cadmium stress, H(+)-ATPase (EC 3.6.3.14) and NADPH oxidase (EC 1.6.3.1). Using anti-phosphothreonine antibody we showed that modification of PM H(+)-ATPase activity under BR action could result from phosphorylation of the enzyme protein. Also the relative expression of genes encoding both PM H(+)-ATPase and NADPH oxidase was affected by BR...
November 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28966307/low-serum-levels-of-eicosapentaenoic-acid-and-docosahexaenoic-acid-are-risk-factors-for-cardiogenic-syncope-in-patients-with-brugada-syndrome
#17
Shusuke Yagi, Takeshi Soeki, Ken-Ichi Aihara, Daiju Fukuda, Takayuki Ise, Muneyuki Kadota, Sachiko Bando, Tomomi Matsuura, Takeshi Tobiume, Koji Yamaguchi, Kenya Kusunose, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike, Masataka Sata
The n-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have antiarrhythmic effects, possibly via modulation of the cardiac ion channels. Nevertheless, it is unknown whether low serum levels of n-3 PUFAs are risk factors for ventricular fibrillation in patients with Brugada syndrome (BrS). We retrospectively reviewed data from 62 men with BrS and evaluated their serum levels of EPA and DHA, and the risk factors for sudden cardiac death, including a history of cardiogenic syncope...
September 30, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28966157/characteristics-and-outcome-of-patients-with-complex-coronary-lesions-treated-with-bioresorbable-scaffolds-three-years-follow-up-in-a-cohort-of-consecutive-patients
#18
Remzi Anadol, Liv Lorenz, Melissa Weissner, Helen Ullrich, Alberto Polimeni, Thomas Münzel, Tommaso Gori
AIMS: The safety of bioresorbable scaffolds (BRS) has recently been challenged. It is however unclear whether outcomes depend on the complexity of the lesion or on the technique used to implant BRS. METHODS AND RESULTS: This investigator-initiated, single-center, single-arm observational study recruited 657 consecutive patients (79% males, 66.7% acute coronary syndromes, age 63±12 years). Three-hundred twenty-two lesions (42.3%) in 297 (45.2%) patients with type B2 or C lesions were classified as "complex lesions group"...
October 3, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28965450/improved-restoration-of-thoracic-kyphosis-using-a-rod-construct-with-differentiated-rigidity-in-the-surgical-treatment-of-adolescent-idiopathic-scoliosis
#19
Søren Ohrt-Nissen, Casper Dragsted, Benny Dahl, John A I Ferguson, Martin Gehrchen
OBJECTIVE The objective of this study was to compare postoperative sagittal alignment among 3 rod constructs with different rigidity profiles. METHODS This was a dual-center retrospective cohort study involving 2 consecutive cohorts in which patients were surgically treated for adolescent idiopathic scoliosis. Lenke Type 5 curves were excluded. Patients were operated on with all-pedicle screw instrumentation using 3 different rod constructs. The first group was operated on using a hybrid construct (HC) consisting of a normal circular rod on the convex side and a beam-like rod (BR) on the concave side...
October 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28956802/local-health-rules-and-building-regulations-a-survey-on-local-hygiene-and-building-regulations-in-italian-municipalities
#20
Marco Gola, Carlo Signorelli, Maddalena Buffoli, Andrea Rebecchi, Stefano Capolongo
INTRODUCTION: WHO has highlighted the need to strengthen the relationship between health and built environment factors, such as inappropriate housing conditions. Local Health Rules (LHRs) and Building Regulations (BRs) are tools which provide safety and building hygiene in construction practices. Currently the Italian Government is considering to establish a National Building Regulation and, related to the following purpose, this paper presents a survey on the status of adoption and updating of LHRs and BRs in Italian municipalities...
July 2017: Annali Dell'Istituto Superiore di Sanità
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