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JOURNAL ARTICLE
C V Chalitsios, D E Shaw, T M McKeever
Concerns have been raised over the association between bisphosphonates and atypical fractures in subtrochanteric and femoral shaft regions, but the potential risk of these fractures due to bisphosphonate use in asthma has not been examined. INTRODUCTION: Bisphosphonates are used as first-line treatment for osteoporosis; however, concerns have been raised over their association with atypical subtrochanteric (ST) and femoral shaft (FS) fractures. The potential risk of atypical ST/FS fractures from bisphosphonate use in asthma has not been examined...
October 11, 2021: Osteoporosis International
#22
JOURNAL ARTICLE
Yu-Lung Hsu, Cheng-Li Lin, Chang-Ching Wei
BACKGROUND: The use of antibiotics for treating infection in childhood and their association with increased risk of asthma remain controversial. Infants diagnosed with vesicoureteral reflux (VUR) belong to a unique population who are administered antibiotics for a long time and are susceptible to recurrent UTI. It is interesting to study the risk of asthma in these infants with or without VUR. METHODS: Taiwanese children born between 2000 and 2007 were enrolled in population-based birth cohort study...
2021: PloS One
#23
JOURNAL ARTICLE
Jonathan Corren, Sarbjit S Saini, Remi Gagnon, Mark H Moss, Gordon Sussman, Joshua Jacobs, Elizabeth Laws, Elinore S Chung, Tatiana Constant, Yiping Sun, Jennifer Maloney, Jennifer D Hamilton, Marcella Ruddy, Claire Q Wang, Meagan P O'Brien
BACKGROUND: Subcutaneous immunotherapy (SCIT) has been proven as an effective therapy against some allergens for seasonal allergic rhinitis (SAR) patients unresponsive to intranasal corticosteroids and/or antihistamines but carries risk of systemic allergic reactions. Dupilumab blocks the shared receptor component for interleukin-4 and interleukin-13, key and central drivers of type 2 inflammation in multiple diseases. OBJECTIVE: To evaluate the efficacy and safety of SCIT+dupilumab vs SCIT alone...
2021: Journal of Asthma and Allergy
#24
Katsunori Masaki, Shigeharu Ueki, Keiji Tanese, Genta Nagao, Sho Kanzaki, Eri Matsuki, Hidehiro Irie, Hiroki Kabata, Jun Miyata, Ichiro Kawada, Koichi Fukunaga
A 56-year-old woman presented with repeated swelling of the lips and face. She had a history of childhood asthma; she had a recurrence of asthma when she was 54 years old and was taking inhaled corticosteroids, and other antiasthma drugs. The swelling of her lips and face improved temporarily with oral corticosteroids (OCS), but recurred soon after discontinuing OCS. Her peripheral blood eosinophil count was 632/μL (9.3%), and her serum was negative for myeloperoxidase-anti-neutrophil cytoplasmic antibody and serine proteinase3-anti-neutrophil cytoplasmic antibody...
July 2021: Asia Pacific Allergy
#25
JOURNAL ARTICLE
Wei Chern Gavin Fong, Susan Grevatt, Stephen Potter, Tracey Tidbury, Latha Kadalayil, Kaisha Bennett, Maria Larsson, Frédéric Nicolas, Ramesh Kurukulaaratchy, Syed Hasan Arshad
BACKGROUND: Indoor air quality has been shown to influence asthma control and outcomes. Air purifiers and high-efficiency particulate air filtration devices can improve indoor air quality by reducing the indoor levels of air pollution and allergens. However, the influence of this improved indoor air quality on asthma control remains unclear; hence, randomized controlled trials are needed to further elucidate this phenomenon. OBJECTIVE: This study aims to investigate the effect of reducing the levels of allergens and pollutants in the bedroom and living room through the use of Dyson air purifiers (Dyson Pure Cool) on asthma control...
July 27, 2021: JMIR Research Protocols
#26
JOURNAL ARTICLE
Soichiro Hozawa, Hiroyuki Ohbayashi, Michiko Tsuchiya, Yu Hara, Laurie A Lee, Takashi Nakayama, Jun Tamaoki, Andrew Fowler, Takanobu Nishi
Purpose: The pivotal CAPTAIN study reported a favorable safety profile with once-daily inhaled corticosteroid/long-acting muscarinic antagonist/long-acting β2 -agonist (ICS/LAMA/LABA) triple combination of fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) in patients with inadequately controlled asthma, some of whom were Japanese. Here, we evaluate the long-term (52 weeks) safety of FF/UMEC/VI in Japanese patients with asthma. Patients and Methods: This was a Phase III, 52-week, multicenter, non-comparator, non-randomized, open-label study (NCT03184987) in Japanese adults receiving maintenance therapy with ICS/LABA, with or without LAMA...
2021: Journal of Asthma and Allergy
#27
JOURNAL ARTICLE
Sanni Hansen, Louise Laustsen, Nina D Otten, Kerstin Skovgaard, Rune Bech, Simon Byrgesen, Charlotte Hopster-Iversen, Julie Fjeldborg
Alternative treatment options to glucocorticoids for equine asthma is desirable due to withdrawal time. The objective was to evaluate if serum and Respiratory Gene Technology (RGT), a commercial kit to produce autologous conditioned serum, was effective in reducing bronchoalveolar lavage (BAL) neutrophils and mast cells in racehorses with cytological evidence of mild equine asthma . Thirty-six Standardbred trotters in active training were enrolled in this randomized clinical trial; a healthy control group (n=11), a RGT group (n=12) and a serum group (n=13)...
June 2021: Journal of Equine Veterinary Science
#28
REVIEW
Jian Xiong, WenChuan Qi, Han Yang, SiTing Zou, Jing Kong, ChengLong Wang, YuanFang Zhou, FanRong Liang
Background: In recent years, there have been many clinical reports on acupuncture treatment of cough-variant asthma, but no researcher has objectively analysed and evaluated the efficacy and safety of acupuncture treatment of cough-variant asthma from the perspective of evidence-based medicine. Objective: To systematically evaluate the clinical efficacy and safety of acupuncture in treating cough-variant asthma and to provide reference values for clinical decision-making...
2021: Evidence-based Complementary and Alternative Medicine: ECAM
#29
RANDOMIZED CONTROLLED TRIAL
Jung-Hyun Kim, Juhae Jin, Seo Young Park, So-Young Park, Hyo-Jung Kim, Min-Hye Kim, Hyouk-Soo Kwon, Woo-Jung Song, Sae-Hoon Kim, Heung-Woo Park, Yoon-Seok Chang, You Sook Cho, Young-Joo Cho, Sang-Heon Cho, Hee-Bom Moon, Tae-Bum Kim
BACKGROUND: Although inhaled corticosteroids (ICSs) are the recommended first-line therapy for asthma, determining whether to continue or discontinue ICS treatment in patients with mild asthma remains challenging for clinicians. Several studies have revealed that patients with mild-persistent asthma maintained a well-controlled state after ICS withdrawal. However, the long-term outcomes of ICS withdrawal have not yet been determined. OBJECTIVE: To determine the possible clinical outcomes of the discontinuation of ICS in patients with well-controlled mild asthma...
July 2021: Annals of Allergy, Asthma & Immunology
#30
JOURNAL ARTICLE
Yang Zhao, Yi-Shan Chen, Hong-Yang Gao, Rui Gao, Bo Li
In order to systematically evaluate the safety of Sanfu acupoint herbal patching, CNKI, SinoMed, VIP, Wanfang, PubMed, Medline, EMbase, and Cochrane Library were searched in accordance with PICOS principles, with a time limit from database establishment to December 2019. Meta-analysis was used for a single-group rate analysis and a weighted combination of these two groups on rates of adverse reactions. A total of 9 articles meeting the inclusion criteria were included in the analysis, involving 2 119 patients...
March 2021: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
#31
REVIEW
M Gurnell, L G Heaney, D Price, A Menzies-Gow
Secondary adrenal insufficiency (AI) occurs as the result of any process that disrupts normal hypothalamic and/or anterior pituitary function and causes a decrease in the secretion of steroid hormones from the adrenal cortex. The most common cause of secondary AI is exogenous corticosteroid therapy administered at supraphysiologic dosages for ≥ 1 month. AI caused by oral corticosteroids (OCS) is not well-recognized or commonly diagnosed but is often associated with reduced well-being and can be life-threatening in the event of an adrenal crisis...
August 2021: Journal of Internal Medicine
#32
RANDOMIZED CONTROLLED TRIAL
Dean A Fennell, Amy King, Seid Mohammed, Amy Branson, Cassandra Brookes, Liz Darlison, Alan G Dawson, Aarti Gaba, Margaret Hutka, Bruno Morgan, Adrian Nicholson, Cathy Richards, Peter Wells-Jordan, Gavin James Murphy, Anne Thomas
BACKGROUND: Malignant mesothelioma remains an incurable cancer, with no effective treatments in the setting of relapsed disease. Homologous recombination deficiency predicts sensitivity to poly (ADP-ribose) polymerase (PARP) inhibitors. In mesothelioma, BRCA1-associated protein 1 carboxy-terminal hydrolase (BAP1), which regulates DNA repair, is frequently mutated. We aimed to test the hypothesis that BAP1-deficient or BRCA1-deficient mesotheliomas would be sensitive to PARP inhibition by rucaparib...
June 2021: Lancet Respiratory Medicine
#33
JOURNAL ARTICLE
Ashish Bansal, Eric L Simpson, Amy S Paller, Elaine C Siegfried, Andrew Blauvelt, Marjolein de Bruin-Weller, Jonathan Corren, Lawrence Sher, Emma Guttman-Yassky, Zhen Chen, Nadia Daizadeh, Mohamed A Kamal, Brad Shumel, Paola Mina-Osorio, Leda Mannent, Naimish Patel, Neil M H Graham, Faisal A Khokhar, Marius Ardeleanu
BACKGROUND: Conjunctivitis is a known comorbidity of atopic dermatitis. Dupilumab clinical trials for moderate-to-severe atopic dermatitis in adults showed a higher conjunctivitis incidence for dupilumab-treated patients than placebo-treated patients, whereas trials for uncontrolled asthma reported lower rates for both dupilumab and placebo. OBJECTIVE: The objective of this study was to evaluate the incidence and severity of conjunctivitis in dupilumab clinical trials in adolescents with moderate-to-severe atopic dermatitis or uncontrolled asthma...
January 2021: American Journal of Clinical Dermatology
#34
JOURNAL ARTICLE
Andrew Briggs, Shuaib Nasser, Eva Hammerby, Sarah Buchs, J Christian Virchow
BACKGROUND: This paper reports the duration of moderate and severe exacerbations in patients with house dust mite induced allergic asthma and the impact on patients' quality of life. METHODS: Post-hoc analyses were conducted using data collected during a phase III multi-national trial (MT-04) that investigated time to moderate or severe asthma exacerbation among 485 patients during withdrawal from inhaled corticosteroids. Patient diaries were analysed to ascertain duration of exacerbations...
January 12, 2021: Journal of Patient-Reported Outcomes
#35
JOURNAL ARTICLE
Li Zhou, Tao Zheng, Zhou Zhu
IL-22 is an IL-10 family cytokine that is increased in asthma and atopic dermatitis (AD). However, the specific role of IL-22 in the pathogenesis of allergic lung inflammation and AD in vivo has yet to be elucidated. We aimed to develop mouse models of allergic diseases in the lung and skin with inducible and tissue-specific expression of IL-22, using a tetracycline (Tet)-controlled system. In this chapter, we describe a series of protocols we have developed to generate a construct that contains the TRE-Tight promoter and mouse IL-22 cDNA based on this system...
2021: Methods in Molecular Biology
#36
JOURNAL ARTICLE
Dong-Woo Han, Jae Seung Lee, Yeon-Mok Oh, Sang-Do Lee, Hwa Jung Kim, Sei Won Lee
BACKGROUND: Maintenance of inhaled corticosteroids (ICSs) is recommended in adults with asthma. However, adherence rates in patients with mild asthma and side effects of long-term ICS use can lead to withdrawal. OBJECTIVE: To analyze the real-world outcomes of ICS withdrawal by analyzing data from the Korean National Health Insurance database. METHODS: Based on claims data from the National Health Insurance of Korea between 2011 and 2014, we identified patients diagnosed with asthma without chronic obstructive pulmonary disease or long-term systemic steroid use who had an ICS medication possession rate of more than 50% in a year...
March 2021: Journal of Allergy and Clinical Immunology in Practice
#37
REVIEW
Giorgio Walter Canonica, Francesco Blasi, Pierluigi Paggiaro, Gianenrico Senna, Giovanni Passalacqua, Antonio Spanevello, Stefano Aliberti, Diego Bagnasco, Marco Bonavia, Matteo Bonini, Luisa Brussino, Caterina Bucca, Maria F Caiaffa, Cecilia Calabrese, Gianna Camiciottoli, Marco Caminati, Giovanna E Carpagnano, Cristiano Caruso, Stefano Centanni, Maria E Conte, Angelo G Corsico, Lorenzo Cosmi, Maria T Costantino, Nunzio Crimi, Simona D'Alò, Maria D'Amato, Stefano Del Giacco, Alessandro Farsi, Elisabetta Favero, Maria P Foschino Barbaro, Gabriella Guarnieri, Giuseppe Guida, Manuela Latorre, Salvatore Lo Cicero, Carlo Lombardi, Luigi Macchia, Francesco Mazza, Francesco Menzella, Manlio Milanese, Marcello Montagni, Paolo Montuschi, Eleonora Nucera, Roberta Parente, Vincenzo Patella, Girolamo Pelaia, Laura Pini, Francesca Puggioni, Luisa Ricciardi, Fabio L M Ricciardolo, Luca Richeldi, Erminia Ridolo, Giovanni Rolla, Pierachille Santus, Nicola Scichilone, Giuseppe Spadaro, Andrea Vianello, Vittorio Viviano, Mona R Yacoub, Maria C Zappa, Enrico Heffler
According to the data derived from several national and international registries, including SANI (Severe Asthma Network Italy), and considering the strong impact that frequent or regular use of oral corticosteroid has on quality of life (QoL) of severe asthmatics, as well as on the costs for managing corticosteroid-related diseases, oral corticosteroid sparing up to withdrawal should be considered a primary outcome in the management of severe asthma. New biologics have clearly demonstrated that this effect is possible, with concomitant reduction in the rate of exacerbations and in symptom control...
October 2020: World Allergy Organization Journal
#38
RANDOMIZED CONTROLLED TRIAL
Ju Hee Kim, Shinhae Lee, Youn Ho Shin, Eun Kyo Ha, Seung Won Lee, Mi-Ae Kim, Jung Won Yoon, Hey Sung Baek, Sun-Hee Choi, Man Yong Han
BACKGROUND: To determine the response of airway mechanics and the changes in asthma symptoms to stepping down of leukotriene receptor antagonist (LTRA) therapy. METHODS: Thirty children (mean age: 7.1 years) with mild, well-controlled, and persistent asthma who took LTRA as maintenance treatment were randomized into a double-blind, placebo-controlled, cross-over study. Each group received an LTRA (montelukast) or placebo daily for 2 weeks, followed by a 1-week washout period, and then the alternate treatment for 2 weeks...
December 2020: Pediatric Pulmonology
#39
JOURNAL ARTICLE
Daniel E Knutson, Rashid Roni, Yeunus Mian, James M Cook, Douglas C Stafford, Leggy A Arnold
We report an improved and scalable synthesis of MIDD0301, a positive GABAA receptor modulator that is under development as oral and inhaled treatments for asthma. In contrast to other benzodiazepines in clinical use, MIDD0301 is a chiral compound that has limited brain absorption. The starting material to generate MIDD0301 is 2-amino-5-bromo-2'-fluorobenzophenone, which has a non-basic nitrogen due to electron withdrawing substituents in the ortho and para positions, reducing its reactivity towards activated carboxylic acids...
August 21, 2020: Organic Process Research & Development
#40
JOURNAL ARTICLE
Ioannis Psallidas, Vibeke Backer, Piotr Kuna, Robert Palmér, Sofia Necander, Malin Aurell, Katarina Korsback, Ziad Taib, Mahdi Hashemi, Per Gustafson, Sara Asimus, Stephen Delaney, Katerina Pardali, Fanyi Jiang, Joachim Almquist, Sam Jackson, Robert L Coffman, David Keeling, Tariq Sethi
RATIONALE: To examine the potential of TLR9 activation to modulate the Type-2 immune response in asthma. OBJECTIVES: To evaluate efficacy and safety of AZD1419, an inhaled TLR9 agonist, in a phase 2a, randomized, double-blind trial. METHODS: Adult asthma patients with a history of elevated eosinophils (>250 cells/μL) were randomized 1:1 to receive 13 once-weekly doses of inhaled AZD1419 (1, 4, or 8 mg; n=40) or placebo (n=41). Inhaled corticosteroids (ICS) and long-acting β2-agonist (LABA) were tapered down and then discontinued...
August 18, 2020: American Journal of Respiratory and Critical Care Medicine
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