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clincal reviews

L Esteban-Lucía, A M Molina-Ruiz, L Requena
Frontal fibrosing alopecia (FFA) is an increasingly common acquired primary scarring alopecia, first described by Kossard in 1994. Clinically it is characterized by frontotemporal hairline recession, frequently accompanied by eyebrow loss. FFA was initially thought to have a hormonal origin as it was first described in postmenopausal women and premenopausal women with a history of hysterectomy or early menopause. This origin, however, has been questioned in recent years due to the publication of cases in men and premenopausal women...
January 20, 2017: Actas Dermo-sifiliográficas
G Casalino, M Williams, C McAvoy, F Bandello, U Chakravarthy
PurposeTo report the clinical course and the optical coherence tomography angiography (OCTA) findings of patients presenting with paracentral acute middle maculopathy (PAMM) and central retinal vein occlusion (CRVO).MethodsRetrospective case series. Clincal records and multimodal imaging findings of patients presenting with PAMM and CRVO were reviewed.ResultsThree eyes of three patients (2 males; mean age: 66 years) were included in the study. Mean follow-up was 9 months and images using OCTA (AngioVue OCT angiography system, Optovue, Inc...
June 2016: Eye
Yi'nan Wang, Yuan Zhou, Heli Liu, Haiping Pei
OBJECTIVE: To investigate the clinical features, diagnosis, treatments and prognosis for gastrointestinal neuroendocrine tumors (GI-NETs).
 METHODS: Clincal data of 52 patients, who were diagnosed as GI-NETs between January 2004 and October 2014, were reviewed. The patients were divided into a local excision group (n=21) and a transabdominal excision group (n=30), and the major clinical features, treatment modalities and outcomes were analyzed.
 RESULTS: The clinical features of GI-NETs were nonspecific, and most of the clinical manifestation were local invasiveness...
March 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Mehmet-Sinan Doğan, Michele Callea, Ìzzet Yavuz, Orhan Aksoy, Gabriella Clarich, Ayse Günay, Ahmet Günay, Sedat Güven, Michele Maglione, Zeki Akkuş
BACKGROUND: This study aimed to review the results related to head and jaw disorders in cases of ectodermal dysplasia. The evaluation of ectodermal dysplasia cases was made by clinical examination and examination of the jaw and facial areas radiologically and on cone-beam 3-dimensional dental tomography (CBCT) images. MATERIAL AND METHODS: In the 36 cases evaluated in the study, typical clinical findings of pure hypohidrotic ectodermal displasia (HED) were seen, such as missing teeth, dry skin, hair and nail disorders...
May 1, 2015: Medicina Oral, Patología Oral y Cirugía Bucal
Andrew R Davies, Robert J Hancox
PURPOSE OF REVIEW: Induced sputum provides a noninvasive way of assessing airway disease. This has led to the identification of different phenotypes of asthma and the potential for individualized treatment targeted at specific pathological processes. However, practical issues limit the frequent use of this technique. This review assesses the extent to which induced sputum can distinguish between asthma phenotypes and guide treatment. RECENT FINDINGS: Although the short-term repeatability of sputum analysis is good, recent research has shown a great deal of variability in sputum inflammatory profiles over follow-up periods of several months to a few years...
January 2013: Current Opinion in Pulmonary Medicine
Neelima Gupta, P P Singh, Usha Rani Singh
Cherubum is a benign. fanilial giant cell lesion characterised by gradually prirgeesive panless swelling of the jaws. A study involving, suffering from this rare disarder is preunted. The differentdal dingnosis ON bath clincal charcteristics and hisioktical ftvltitgs is disussed. The conficting treatmem policlm with respect to non-treatment and surgirai recentouring with curenage, are also reviewed.
July 2002: Indian Journal of Otolaryngology and Head and Neck Surgery
Xiang Wu, Yi Cui, Yingping Gong, Hainan Xu, Dan Jiang, Shengjun Meng
OBJECTIVE: To analyze the clinical pathologic characteristics of cervical intraepithelial neoplasia grade III (CINIII ) and to explore optimal surgery for CINIII patients. METHODS: The clinical pathologic characteristics, surgical treatments, prognosis and history of 383 CINIII patients, who hospitalized from August 2005 to December 2010, were reviewed and analyzed. Among the patients, 213 (55.6%) received cold-knife conization surgery and 170 (44.4%) received ordinary electric knife conization surgery...
August 2012: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Kevin W-H Lo, Bret D Ulery, Keshia M Ashe, Cato T Laurencin
Over the past several decades, recombinant human bone morphogenetic proteins (rhBMPs) have been the most extensively studied and widely used osteoinductive agents for clinical bone repair. Since rhBMP-2 and rhBMP-7 were cleared by the U.S. Food and Drug Administration for certain clinical uses, millions of patients worldwide have been treated with rhBMPs for various musculoskeletal disorders. Current clinical applications include treatment of long bone fracture non-unions, spinal surgeries, and oral maxillofacial surgeries...
September 2012: Advanced Drug Delivery Reviews
Katarzyna Starska, Marek Lukomski, Iwona Lewy-Trenda
The Actinomysec spp. are common saprophytic microorganisms which are found in the oral cavity, pharynx and palatine tonsils. The actinomycotic infections can be responsible for recurrent chronic tonsillitis. Data about presence of actinomycotic granules in tonsillar tissue and their influence clincal course are controversial in the available literarure sources. The presence study assesses the appearance of actinomycetes and the character of their invasivenes in the tonsillar tissue affilicted with chronic tonsillitis after tonsillectomy which were performed in Department of Otolaryngology Medical University of Lódź in 2005...
2006: Otolaryngologia Polska. the Polish Otolaryngology
Michaell A Huber, Geza T Terezhalmy
BACKGROUND: On the basis of their perceived better safety profile compared with other analgesic agents, cyclo-oxygenase-2 (COX-2) inhibitors have been prescribed frequently as first-line agents to treat acute dental pain. However, recently identified cardiovascular adverse reactions associated with these drugs mandate a reappraisal of their use in dental practice. TYPES OF STUDIES REVIEWED. The authors reviewed 18 clinical studies that evaluated the efficacy of a COX-2 inhibitor for the treatment of acute dental pain...
April 2006: Journal of the American Dental Association
Peter E Clark, John P Stein, Susan G Groshen, Jie Cai, Gus Miranda, Gary Lieskovsky, Donald G Skinner
BACKGROUND: The authors report their experience with radical cystectomy for transitional cell carcinoma (TCC) of the bladder comparing clinical outcomes, including complication rates, among older patients versus younger patients in a high-volume center specializing in the treatment of patients with advanced carcinoma of the urinary bladder. METHODS: A retrospective review was undertaken of 1054 patients who underwent radical cystectomy for bladder TCC from 1971 through 1997...
July 1, 2005: Cancer
Elke C Bornhövd, Walter H C Burgdorf, Andreas Wollenberg
Tacrolimus (FK-506; Fujisawa Pharmaceutical Co Ltd) and pimecrolimus (SDZ-ASM-981; Novartis AG) are topical immunomodulators, which provide an alternative to glucocorticosteroids for the topical treatment of atopic dermatitis and other inflammatory dermatoses. Both substances form a complex with cytosolic immunophilins. The complex blocks calcineurin and inhibits the transcription of NF-AT-dependent pro-inflammatory cytokine genes. Multicenter, randomized, double-blind clinical trials have shown the efficacy of both substances in atopic dermatitis...
May 2002: Current Opinion in Investigational Drugs
S Garner, D Fidan, R Frankish, M Judd, T Towheed, G Wells, P Tugwell
BACKGROUND: Rheumatoid arthritis (RA) is a systemic auto-immune disorder, in which the synovial lining of many joints and tendon sheaths are persistently inflamed. OBJECTIVES: To assess the efficacy and toxicity of rofecoxib for treating RA. SEARCH STRATEGY: We searched the following databases up to December 2000: MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Controlled Trials Register, National Research Register, NHS Economic Evaluation Database, Health Technology Assessment database...
2002: Cochrane Database of Systematic Reviews
S Cipri, G Gambardella, C Campolo, R Mannino, D Consoli
The authors report the case of a 31-year-old man, who presented an hemorrhagic onset of a cerebral-isolated sarcoidosis, to date never described in the literature. Unusual clinical manifestation, neuroradiological study and direct histological confirmation are presented. Moreover, Gallium-67 Single Photon Emission Computed Tomography (Ga-67 SPECT) contribution is indicated to complete the evaluation of patients with cerebral inflammatory lesions, such as neurosarcoidosis, and in cases of equivocal neuroradiological imaging, to evaluate uptake activity of the inflammatory tissue...
September 2000: Journal of Neurosurgical Sciences
R E Bundy, N Marczin, E F Birks, A H Chester, M H Yacoub
Occlusive accelerated atherosclerosis of coronary grafts is the predominant factor that limits longevity of heart transplant recipients. This form of vascular disease affects both the large epicardial and the smaller intramyocardial vessels, leading to characteristic clinical presentation that necessitates the use of sophisticated techniques for their accurate detection. Accelerated atherosclerosis after transplantation is a multifactorial disease with many events contributing to its progression. The initial vascular injury associated with ischemia-reperfusion appears to aggravate preexisting conditions in the donor vasculature in addition to activation of new immunological and nonimmunological mechanisms...
February 2000: General Pharmacology
Perez, Eisbruch
The indications and results of postradical prostatectomy adjuvant pelvic radiation therapy (6,000 to 6,500 cGy) are reviewed. In patients with positive with positive surgical margins, 80% to 100% local tumor control has been reported; in 42 patients treated at our institution, the 5-year actuarial tumor control rate was 85%. Most authors report higher disease-free survival (DFS) rates in patients receiving adjuvant postoperative irradiation for positive margins (70% to 80% at 5 years and 50% to 70% at 10 years) compared with nonirradiated patients (50% at 5 years and 40% at 10 years)...
July 1993: Seminars in Radiation Oncology
P Rietti, M Marzegalli, C Schmid, C Zogno, M Morpurgo
UNLABELLED: In our experience electromechanical dissociation (EMD) is the most common mechanism of fatal cardiac arrest in patients with acute myocardial infarction (AMI). METHODS: We reviewed retrospectively 82 autopsy cases of AMI in whom the medical record documented EMD as terminal cardiac arrest in order to outline the clinical and pathologic features of different subgroups: 26 cases with external cardiac rupture (CR) were compared with 56 cases without CR...
April 1997: Minerva Cardioangiologica
F Alexander, E L Atkins
Three siblings (two brothers and a sister) of Polish origin, presented in late middle age with the features of the nephrotic syndrome and hypertension. Glomerular deposition of amyloid was found in all on renal biopsy. No amyloid was seen on rectal or gingival biopsy. Their mother and a maternal aunt died in middle age with a clincally similar disease. These cases are compared with other forms of hereditary amyloidosis which are briefly reviewed. The hereditary amyloidoses are classified with particular emphasis on neural and renal involvement...
July 1975: American Journal of Medicine
H J Lerner
This detailed review of the clincal and pathologic signs which effect the prognosis of patients with colorectal cancer. The following are reviewed: (1) the degree of cellular anaplasia, (2) local penetration of the bowel wall, (3) lymph-node spread, (4) venous invasion, (5) perineural invasion, (6) obstruction and perforation, and (7) the number of cm the lesion is located from the anal verge.
1975: Journal of Surgical Oncology
C J Allison
A chronic wasting disease in a 16 month old Welsh pony filly is described. The animal died 26 days after the onset of illness which commenced with a sub-acute colic and was characterised by progressive loss of appetite and weight. Post-mortem examination revealed a total invagination of the caecum into the colon and it seemed logical to assume this invagination occurred at the start of the illness. A review of the literature showed that total caecal invagination produces 2 distinct clincal syndromes. It can occur either as an acute illness characterised by severe colic and death after about 10 days, or as a chronic wasting disease, such as the case presented here, which may not result in death for several weeks or even months...
April 1977: Equine Veterinary Journal
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