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Ovarian failure

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https://www.readbyqxmd.com/read/29929924/unplanned-postoperative-intensive-care-unit-admission-for-ovarian-cancer-cytoreduction-is-associated-with-significant-decrease-in-overall-survival
#1
Malcolm S Ross, Mary E Burriss, Daniel G Winger, Robert P Edwards, Madeleine Courtney-Brooks, Michelle M Boisen
OBJECTIVES: Previous studies have identified age, nutritional status, and hematocrit as risk factors for unplanned ICU admission in gynecologic oncology patients. We sought to identify additional perioperative factors that can be predictive of unplanned ICU admission and its impact on outcomes in women with ovarian cancer undergoing ovarian cancer cytoreductive procedures. METHODS: This was a case-control study of patients with unplanned ICU admission after primary surgery for ovarian cancer from January 2007 to December 2013...
June 18, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29928579/augmentation-of-the-therapeutic-efficacy-of-wee1-kinase-inhibitor-azd1775-by-inhibiting-the-yap-e2f1-dna-damage-response-pathway-axis
#2
Yusuke Oku, Naoyuki Nishiya, Takaaki Tazawa, Takaya Kobayashi, Nanami Umezawa, Yasuyo Sugawara, Yoshimasa Uehara
The main reasons for failure of cancer chemotherapy are intrinsic and acquired drug resistance. The Hippo pathway effector Yes-associated protein (YAP) is associated with resistance to both cytotoxic and molecular targeted drugs. Several lines of evidence indicate that YAP activates transcriptional programmes to promote cell cycle progression and DNA damage responses. Therefore, we hypothesised that YAP is involved in the sensitivity of cancer cells to small-molecule agents targeting cell cycle-related proteins...
June 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29928353/identification-of-proteins-associated-with-paclitaxel-resistance-of-epithelial-ovarian-cancer-using-itraq-based-proteomics
#3
Yuanjing Wang, Hongxia Li
Chemotherapy is an important adjuvant therapy for epithelial ovarian cancer (EOC). The main cause of chemotherapy failure in EOC is paclitaxel resistance. The present study aimed to identify novel biomarkers to predict chemosensitivity to paclitaxel and improve our understanding of the molecular mechanisms underlying paclitaxel resistance in EOC. In the present study, the heterogeneity of EOC was evaluated by adenosine triphosphate-tumor chemosensitivity assay (ATP-TCA) in vitro . Fresh samples were collected from 54 EOC cases during cytoreductive surgery...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29922706/soy-protein-improves-tibial-whole-bone-and-tissue-level-biomechanical-properties-in-ovariectomized-and-ovary-intact-low-fit-female-rats
#4
Pamela S Hinton, Laura C Ortinau, Rebecca K Dirkes, Emily L Shaw, Matthew W Richard, Terese Z Zidon, Steven L Britton, Lauren G Koch, Victoria J Vieira-Potter
Background: Osteoporosis and related fractures, decreased physical activity, and metabolic dysfunction are serious health concerns for postmenopausal women. Soy protein might counter the negative effects of menopause on bone and metabolic health due to the additive or synergistic effects of its bioactive components. Objective: To evaluate the effects of ovariectomy (OVX) and a soy-protein diet (SOY) on bone outcomes in female, low-capacity running (LCR) rats selectively bred for low aerobic fitness as a model of menopause...
June 2018: Bone Reports
https://www.readbyqxmd.com/read/29920379/management-of-endometriosis-cngof-has-clinical-practice-guidelines-short-version
#5
P Collinet, X Fritel, C Revel-Delhom, M Ballester, P A Bolze, B Borghese, N Bornsztein, J Boujenah, T Brillac, N Chabbert-Buffet, C Chauffour, N Clary, J Cohen, C Decanter, A Denouël, G Dubernard, A Fauconnier, H Fernandez, T Gauthier, F Golfier, C Huchon, G Legendre, J Loriau, E Mathieu-d'Argent, B Merlot, J Niro, P Panel, P Paparel, C A Philip, S Ploteau, C Poncelet, B Rabischong, H Roman, C Rubod, P Santulli, M Sauvan, I Thomassin-Naggara, A Torre, J M Wattier, C Yazbeck, N Bourdel, M Canis
First-line diagnostic investigations for endometriosis are physical examination and pelvic ultrasound. The second-line investigations are: targeted pelvic examination performed by an expert clinician, transvaginal ultrasound performed by an expert physician sonographer (radiologist or gynaecologist), and pelvic MRI. Management of endometriosis is recommended when the disease has a functional impact. Recommended first-line hormonal therapies for the management of endometriosisrelated pain are combined hormonal contraceptives (CHCs) or the 52mg levonorgestrel-releasing intrauterine system (IUS)...
June 16, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29916276/association-of-estrogen-progesterone-and-follicle-stimulating-hormone-receptor-polymorphisms-with-in-vitro-fertilization-outcomes
#6
Vijaya Ganesh, Vettriselvi Venkatesan, Teena Koshy, Sanjeeva Nellapalli Reddy, Suruli Muthumuthiah, Solomon Franklin Durairaj Paul
Despite the advances in in vitro fertilization (IVF), the implantation success rate for infertile women remains approximately only 15%. In this study, we sought to determine whether implantation failure after repeated IVF treatments is influenced by the presence of common variants in estrogen α, progesterone and follicle stimulating hormone receptor genes. The study population included three groups of women: group 1 were 50 women who had the transfer of ≥3 high-quality embryos during the IVF procedure without ever having had a clinical pregnancy; group 2 were 50 women who achieved a clinical pregnancy after ≤3 high-quality embryos transfers and group 3 were 50 control subjects who achieved a clinical pregnancy without any fertility therapy that resulted in a one live-born infant...
June 19, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29905462/the-human-biomolecular-corona-of-liposomal-doxorubicin-the-overlooked-factor-in-anticancer-drug-delivery
#7
Giulio Caracciolo, Sara Palchetti, Luca Digiacomo, Riccardo Zenezini Chiozzi, Anna Laura Capriotti, Heinz Amenitsch, Paolo Maria Tentori, Valentina Palmieri, Massimiliano Papi, Francesco Cardarelli, Daniela Pozzi, Aldo Laganà
More than twenty years after its approval by the Food and Drug Administration (FDA) liposomal doxorubicin (DOX) is still the drug of choice for the treatment of breast cancer and other conditions such as ovarian cancer and multiple myeloma. Yet, despite the efforts, liposomal DOX did not satisfy expectations at the clinical level. When liposomal drugs enter a physiological environment, their surface gets coated by a dynamic biomolecular corona (BC). The BC changes liposome's synthetic identity, providing it with a new one, referred to as 'biological identity' (size, aggregation state, and BC composition)...
June 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29903044/he4-level-in-ascites-may-assess-the-ovarian-cancer-chemotherapeutic-effect
#8
Duanyang Liu, Dan Kong, Jing Li, Lei Gao, Di Wu, Yu Liu, Weiwei Yang, Lei Zhang, Jiang Zhu, Xiaoming Jin
BACKGROUND: The clinical treatment of ovarian cancer with ascites is problematic. The main reasons for treatment failure are the susceptibility to intraperitoneal metastasis and chemotherapeutic drug resistance. The purpose and significance of this study is to evaluate which marker might evaluate treatment efficacy and improve the cure rate. RESULTS: This study compared a no chemotherapy group with a chemotherapy group regarding the determination of carbohydrate antigen 125 and human epididymis protein 4 in ovarian cancer ascitic supernatants and cross-analyzed routine serum carbohydrate antigen 125 levels...
June 14, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29893277/stereotactic-body-radiation-therapy-for-oligometastatic-ovarian-cancer-a-step-toward-a-drug-holiday
#9
Roberta Lazzari, Sara Ronchi, Sara Gandini, Alessia Surgo, Stefania Volpe, Gaia Piperno, Stefania Comi, Floriana Pansini, Cristiana Fodor, Roberto Orecchia, Federica Tomao, Gabriella Parma, Nicoletta Colombo, Barbara Alicja Jereczek-Fossa
PURPOSE: To evaluate stereotactic body radiation therapy (SBRT) for metachronous oligometastatic ovarian cancer patients in terms of local control, delay of systemic treatment, survival outcomes, and toxicity. METHODS AND MATERIALS: Retrospective data collection from a single institution was performed. The inclusion criteria were as follows: (1) oligorecurrent or oligoprogressive disease in ovarian cancer patients during or after systemic therapy; (2) surgery or other local therapies not feasible; and (3) relative contraindication to systemic therapy for reasons such as unavailability of additional chemotherapy lines or refusal of the patient...
July 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29889622/a-lowered-probability-of-pregnancy-in-females-in-the-usa-aged-25-29-who-received-a-human-papillomavirus-vaccine-injection
#10
Gayle DeLong
Birth rates in the United States have recently fallen. Birth rates per 1000 females aged 25-29 fell from 118 in 2007 to 105 in 2015. One factor may involve the vaccination against the human papillomavirus (HPV). Shortly after the vaccine was licensed, several reports of recipients experiencing primary ovarian failure emerged. This study analyzed information gathered in National Health and Nutrition Examination Survey, which represented 8 million 25-to-29-year-old women residing in the United States between 2007 and 2014...
June 11, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29879312/effect-of-a-gonadotropin-releasing-hormone-analog-for-ovarian-function-preservation-after-intravenous-cyclophosphamide-therapy-in-systemic-lupus-erythematosus-patients-a-retrospective-inception-cohort-study
#11
Tomohiro Koga, Masataka Umeda, Yushiro Endo, Midori Ishida, Yuya Fujita, Sosuke Tsuji, Ayuko Takatani, Toshimasa Shimizu, Remi Sumiyoshi, Takashi Igawa, Shoichi Fukui, Ayako Nishino, Shin-Ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Naoko Murakami, Michio Kitajima, Atsushi Kawakami
OBJECTIVE: To determine the effect of leuprolide acetate, a synthetic gonadotropin-releasing hormone analog (GnRH-a) on ovarian function preservation in systemic lupus erythematosus (SLE) patients treated with cyclophosphamide (CYC) in clinical practice. METHODS: We enrolled 30 premenopausal female SLE patients who fulfilled the 1997 American College of Rheumatology revised criteria and were treated with intravenous CYC (IVCY) in 2008-2017. We used Kaplan-Meier survival estimates to compare the GnRH-a-treated patients and those not treated with GnRH-a as controls...
June 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29876729/functional-testing-of-primitive-oocyte-like-cells-developed-in-ovarian-surface-epithelium-cell-culture-from-small-vsel-like-stem-cells-can-they-be-fertilized-one-day
#12
Irma Virant-Klun
Data from the literature show that there are different populations of stem cells present in human adult ovaries, including small stem cells resembling very small embryonic-like stem cells (VSELs). These small ovarian stem cells with diameters of up to 5 μm are present in the ovarian surface epithelium and can grow into bigger, primitive oocyte-like cells that express several markers of a germinal lineage and exhibit pluripotency but not the zona pellucida structure when cultured in vitro. In this report, we present the results of the functional testing of such primitive oocyte-like cells from one patient with premature ovarian failure after insemination with her partners' sperm...
June 6, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29860321/premature-ovarian-insufficiency-and-early-depletion-of-the-ovarian-reserve-in-the-monogenic-mulibrey-nanism-disorder
#13
Susann Karlberg, Aila Tiitinen, Henrik Alfthan, Marita Lipsanen-Nyman
STUDY QUESTION: What is the timing of onset and clinical course of premature ovarian insufficiency (POI) in patients with Mulibrey nanism (MUL), a monogenic disorder caused by mutations of the peroxisomal TRIM37 gene? SUMMARY ANSWER: The number of ovarian follicles is highly reduced already in infant and young MUL girls and the majority of them will have early depletion of follicles resulting in clinical and biochemical signs of POI. WHAT IS KNOWN ALREADY: Both female and male patients with MUL show failure of sexual maturation, signs of hypogonadism and infertility...
June 1, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29849943/zebrafish-androgen-receptor-is-required-for-spermatogenesis-and-maintenance-of-ovarian-function
#14
Guangqing Yu, Dawei Zhang, Wei Liu, Jing Wang, Xing Liu, Chi Zhou, Jianfang Gui, Wuhan Xiao
The androgen receptor (AR) is a nuclear receptor protein family member and inducible transcription factor that modulates androgen target gene expression. Studies using a mouse model confirmed the need for ar in reproductive development, particularly spermatogenesis. Here, we investigated the role of ar in zebrafish using CRISPR/Cas9 gene targeting technology. Targeted disruption of ar in zebrafish increases the number of female offspring and increases offspring weight. In addition, ar -null male zebrafish have female secondary sex characteristics...
May 11, 2018: Oncotarget
https://www.readbyqxmd.com/read/29849781/mir-423-5p-serves-as-a-diagnostic-indicator-and-inhibits-the-proliferation-and-invasion-of-ovarian-cancer
#15
Xuebiao Tang, Xiaogang Zeng, Yu Huang, Shibing Chen, Fang Lin, Ge Yang, Nian Yang
MicroRNA (miR)-423-5p is a potential target for the diagnosis and therapy of heart failure and cancer. The present study aimed to investigate the expression and role of miR-423-5p in ovarian cancer. miR-423-5p expression in ovarian tissues and plasma collected from ovarian cancer patients and healthy volunteers was analyzed by polymerase chain reaction analysis. In addition, a cell proliferation assay, clonogenic assay and Matrigel-based assay were performed to evaluate the role of miR-423-5p in ovarian cancer cells...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29843988/oncologic-safety-of-gonadotropin-releasing-hormone-agonist-for-ovarian-function-protection-during-breast-cancer-chemotherapy
#16
Hee Jeong Kim, Moo Hyun Lee, Jeong Eon Lee, Seho Park, Eun Sook Lee, Yong Joon Kang, Hae Na Shin, Seung Il Kim, Jun Ho Lee, Seock Ah Im, Sei Hyun Ahn, Keun Seok Lee, Joohyuk Sohn, Seonok Kim, Seok Jin Nam, Wonshik Han
BACKGROUND: Receipt of a gonadotropin-releasing hormone (GnRH) agonist has been reported to protect against ovarian failure. We sought to determine the oncologic effect of a GnRH agonist with chemotherapy for breast cancer patients. PATIENTS AND METHODS: Data from 1160 patients aged 20 to 40 years with stage I to III breast cancer who received chemotherapy from 5 hospitals in Korea from 2002 to 2012 were reviewed. A GnRH agonist was provided to 406 patients for ovarian protection during chemotherapy, and 754 patients received chemotherapy without ovarian protection...
April 19, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29805405/cross-talk-between-serum-kisspeptin-leptin-during-assisted-reproduction-techniques
#17
Rehana Rehman, Zehra Jamil, Aqsa Khalid, Syeda Sadia Fatima
Background & objective: Leptin facilitates onset of puberty by impact on hypothalamic Kisspeptin, gonadotropin releasing hormone, follicle stimulating and luteinizing hormone. The link of peripheral Leptin-Kisspeptin in regulating the ovarian and endometrial tissue in relation to adiposity is unknown. Therefore, we wanted to identify Kisspeptin-Leptin association with body mass index (BMI) and success of assisted reproductive treatments (ART) in infertile females. Methods: A cross sectional study was carried from August 2014 till May 2016 after receiving ethical approval at Australian Concept Infertility Medical Centre, and Aga Khan University...
March 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29797923/-clinical-research-and-the-effect-mechanism-on-premature-ovarian-failure-treated-with-acupuncture-in-recent-20-years
#18
Liangjun Xia, Youbing Xia
OBJECTIVE: To review and collect the study achievements and the effect mechanism of acupuncture in the treatment of premature ovarian failure (POF) in recent 20 years so as to provide more references for the clinical treatment of POF with acupuncture. METHODS: Through retrieving PubMed, CNKI and VIP, the literature on acupuncture for POF was collected from January 1, 1998 through March 31, 2017 regarding the rule of acupoint selection and the therapeutic method...
May 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29795269/loss-of-puma-protects-the-ovarian-reserve-during-dna-damaging-chemotherapy-and-preserves-fertility
#19
Quynh-Nhu Nguyen, Nadeen Zerafa, Seng H Liew, F Hamish Morgan, Andreas Strasser, Clare L Scott, Jock K Findlay, Martha Hickey, Karla J Hutt
Female gametes are stored in the ovary in structures called primordial follicles, the supply of which is non-renewable. It is well established that DNA-damaging cancer treatments can deplete the ovarian reserve of primordial follicles, causing premature ovarian failure and infertility. The precise mechanisms underlying this chemotherapy-driven follicle loss are unclear, and this has limited the development of targeted ovarian-protective agents. To address this fundamental knowledge gap, we used gene deletion mouse models to examine the role of the DNA damage-induced pro-apoptotic protein, PUMA, and its transcriptional activator TAp63, in primordial follicle depletion caused by treatment with cyclophosphamide or cisplatin...
May 23, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29794258/premature-ovarian-failure-of-autoimmune-etiology-in-46xx-patients-is-there-a-hope
#20
Ayman Shehata Dawood, Mohamed Ahmed El-Sharawy, Doaa Waseem Nada, Mohamed Fadel El-Sheikh
OBJECTIVES: To evaluate the efficacy of live bee stings at fertility points and acupuncture in treating symptoms and managing infertility in premature ovarian failure (POF) of autoimmune etiology. PATIENTS AND METHODS: Patients with primary POF were allocated randomly into two groups: group I: subjected to acupuncture at specific fertility points and group II: subjected to live bee stings at sites of fertility points. RESULTS: A total of 24 cases show significant reduction of Follicle stimulating hormone (FSH) level to normal range with gradual decline over the study duration: 13 cases in group I and 11 cases in group II...
May 25, 2018: Journal of Complementary & Integrative Medicine
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