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https://www.readbyqxmd.com/read/29673835/effects-of-ovarian-reserve-and-hormone-therapy-on-hearing-in-premenopausal-and-postmenopausal-women-a-cross-sectional-study
#1
Jingfei Zhang, Tingyue Zhang, Lisheng Yu, Qianying Ruan, Lingxue Yin, Dong Liu, Haicheng Zhang, Wenpei Bai, Zhenghong Ren
OBJECTIVES: To observe the hearing function around menopause, to analyze the effects of ovarian reserve and hormone therapy on hearing, and to study factors related to hearing loss among women around menopause. STUDY DESIGN: In this cross-sectional study, we evaluated 109 women around menopause aged 45-55 years, including 40 women with ovarian failure, 48 with ovarian non-failure, and 21 receiving hormone therapy. All women underwent an audiologic evaluation, and hormone blood testing was performed...
May 2018: Maturitas
https://www.readbyqxmd.com/read/29668891/maternal-polycystic-ovarian-syndrome-and-early-offspring-development
#2
Griffith A Bell, Rajeshwari Sundaram, Sunni L Mumford, Hyojun Park, James Mills, Erin M Bell, Miranda Broadney, Edwina H Yeung
STUDY QUESTION: Is maternal polycystic ovarian syndrome (PCOS) associated with developmental delays in offspring? SUMMARY ANSWER: Offspring of mothers with PCOS were at higher risk of failure on the Ages and Stages Questionnaire (ASQ). WHAT IS KNOWN ALREADY: There is growing evidence that offspring of mothers with PCOS may be at higher risk for developmental disorders due to potential exposure to hyperandrogenism and insulin resistance. Few studies exist regarding maternal PCOS and early childhood development in the USA...
April 13, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29662190/autocrine-activation-of-jak2-by-il-11-promotes-platinum-drug-resistance
#3
Wei Zhou, Wei Sun, Mingo M H Yung, Sheng Dai, Yihua Cai, Chi-Wei Chen, Yunxiao Meng, Jennifer B Lee, John C Braisted, Yinghua Xu, Noel T Southall, Paul Shinn, Xuefeng Huang, Zhangfa Song, Xiulei Chen, Yan Kai, Xin Cai, Zongzhu Li, Qiang Hao, Annie N Y Cheung, Hextan Y S Ngan, Stephanie S Liu, Stephanie Barak, Jing Hao, Zhijun Dai, Alexandros Tzatsos, Weiqun Peng, Huadong Pei, Zhiyong Han, David W Chan, Wei Zheng, Wenge Zhu
Antineoplastic platinum agents are used in first-line treatment of ovarian cancer, but treatment failure frequently results from platinum drug resistance. Emerging observations suggest a role of reactive oxygen species (ROS) in the resistance of cancer drugs including platinum drugs. However, the molecular link between ROS and cellular survival pathway is poorly understood. Using quantitative high-throughput combinational screen (qHTCS) and genomic sequencing, we show that in platinum-resistant ovarian cancer elevated ROS levels sustain high level of IL-11 by stimulating FRA1-mediated IL-11 expression and increased IL-11 causes resistance to platinum drugs by constitutively activating JAK2-STAT5 via an autocrine mechanism...
April 17, 2018: Oncogene
https://www.readbyqxmd.com/read/29621137/trap1-regulation-of-cancer-metabolism-dual-role-as-oncogene-or-tumor-suppressor
#4
REVIEW
Danilo Swann Matassa, Ilenia Agliarulo, Rosario Avolio, Matteo Landriscina, Franca Esposito
Metabolic reprogramming is an important issue in tumor biology. An unexpected inter- and intra-tumor metabolic heterogeneity has been strictly correlated to tumor outcome. Tumor Necrosis Factor Receptor-Associated Protein 1 (TRAP1) is a molecular chaperone involved in the regulation of energetic metabolism in cancer cells. This protein is highly expressed in several cancers, such as glioblastoma, colon, breast, prostate and lung cancers and is often associated with drug resistance. However, TRAP1 is also downregulated in specific tumors, such as ovarian, bladder and renal cancers, where its lower expression is correlated with the worst prognoses and chemoresistance...
April 5, 2018: Genes
https://www.readbyqxmd.com/read/29620984/controlled-ovarian-stimulation-for-in-vitro-fertilization
#5
Ruth Howie, Vanessa Kay
Controlled ovarian stimulation with gonadotrophins is an essential part of in-vitro fertilization treatment. The aim is to produce an optimum number of oocytes to maximize success in the safest possible way. Pituitary downregulation with a gonadotrophin-releasing hormone agonist and stimulation with recombinant follicle-stimulating hormone is used widely. However, there are many different protocols in use with little evidence to determine the optimum regimen. Markers of ovarian reserve and patient characteristics are used in an attempt to individualize treatment...
April 2, 2018: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/29620680/triptorelin-for-fertility-preservation-in-adolescents-treated-with-chemotherapy-for-cancer
#6
Mariaclaudia Meli, Manuela Caruso-Nicoletti, Milena La Spina, Luca Lo Nigro, Piera Samperi, Salvatore D'Amico, Francesco Bellia, Vito Miraglia, Maria Licciardello, Emanuela Cannata, Silvia Marino, Carla Cimino, Federica Puglisi, Laura Lo Valvo, Agnese Pezzulla, Giovanna Russo, Andrea Di Cataldo
BACKGROUND: Triptorelin, a gonadotropin releasing hormone analogue, can be administered to postpubertal female individuals with cancer who receive chemotherapy to obtain menstrual suppression and decrease the risk of hemorrhage caused by thrombocytopenia. Our goal was to assess whether triptorelin also has a protective role against the gonadotoxicity of chemotherapy. PATIENTS AND METHODS: This retrospective observational study includes all postmenarchal female patients who presented to our Unit from 2000 to 2015 and received chemotherapy for cancer...
April 3, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29619566/utility-of-pediatric-female-fertility-preservation-discussions-following-pelvic-radiation
#7
Rebecca M Rentea, Ashwini S Poola, Joy M Fulbright, Shawn D St Peter, Sohail R Shah
INTRODUCTION: While many childhood cancers are curable with therapy, adverse consequences in fertility exist. We sought to assess the number of female patients with pelvic tumors receiving radiation therapy, and the proportion that undergo measures for fertility preservation (FP). METHODS: A total of 53 female patients treated with pelvic tumors from 2000 to 2016 were retrospectively identified. RESULTS: 19 (34%) of these patients underwent pelvic radiation therapy (pXRT)...
April 4, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29618356/in-vitro-maturation-of-oocytes-from-excised-ovarian-tissue-in-a-patient-with-autoimmune-ovarian-insufficiency-possibly-associated-with-epstein-barr-virus-infection
#8
Irma Virant-Klun, Andrej Vogler
BACKGROUND: Some reports show that it is possible to isolate immature oocytes from human ovarian tissue retrieved by a cortex biopsy or ovariectomy of non-stimulated ovaries and mature them in vitro. The mature oocytes can be vitrified and stored for in vitro fertilization, which, along with ovarian tissue cryopreservation, is mostly practiced in young cancer patients to preserve their fertility. There is much less data on this new approach in women with a natural ovarian insufficiency, which can be caused by different factors, including viral infection...
April 5, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29615109/human-chorionic-plate-derived-mesenchymal-stem-cells-transplantation-restores-ovarian-function-in-a-chemotherapy-induced-mouse-model-of-premature-ovarian-failure
#9
Jun Li, Qingtong Yu, Haisen Huang, Wenwen Deng, Xia Cao, Michael Adu-Frimpong, Jiangnan Yu, Ximing Xu
BACKGROUND: Previous studies have reported that transplantation of mesenchymal stem cells (MSCs) from many human tissues could ameliorate ovarian dysfunction. However, no study has revealed the therapeutic efficiency of MSCs derived from the chorionic plate (CP-MSCs) for premature ovarian failure (POF). METHODS: We investigated the restorative effects of CP-MSCs on cyclophosphamide (CTX)-induced POF. The POF mouse models were established via intraperitoneal injection of 50 mg/kg CTX into female mice for 15 consecutive days...
April 3, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29607913/eldecalcitol-increases-bone-mass-in-patients-with-turner-syndrome-who-have-insufficient-bone-mass-acquisition-after-estrogen-replacement-therapy
#10
Taku Tsuburai, Tomomi Nakamura, Hiromi Yoshikata, Etsuko Miyagi, Hideya Sakakibara
Most patients with Turner syndrome (TS) exhibit amenorrhea due to premature ovarian failure. Therefore, estrogen replacement therapy (ERT) is required; however, even after undergoing ERT, it is not rare for bone mass acquisition to be insufficient. This study was conducted in two stages, involving a cross-sectional and a prospective interventional study. We recruited 52 TS patients undergoing ERT due to amenorrhea (categorized into low (LB group; n = 23), and normal (NB group; n = 29) bone mass groups) and 7 TS patients who maintained ovarian function (spontaneous menstrual cycle group (MC group)) as controls...
March 31, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29592908/dilated-cardiomyopathy-and-premature-ovarian-failure-unveiling-propionic-aciduria
#11
Sarah Grotto, Bénédicte Sudrié-Arnaud, Valérie Drouin-Garraud, Catherine Nafeh-Bizet, Bernadette Chadefaux-Vekemans, Stéphanie Gobin, Soumeya Bekri, Abdellah Tebani
No abstract text is available yet for this article.
April 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29581237/female-fertility-preservation-past-present-and-future
#12
Benjamin Fisch, Ronit Abir
Anti-cancer therapy, particularly chemotherapy damages ovarian follicles and promotes ovarian failure. The only pharmacological means for protecting the ovaries from chemotherapy-induced injury is gonadotrophin-releasing hormone agonist, but its efficiency remains controversial; ovarian transposition is used to shield the ovary from radiation when indicated. Until the late 1990s, the only option for fertility preservation and restoration in women with cancer was embryo cryopreservation. The development of other assisted reproductive technologies such as mature oocyte cryopreservation and in vitro maturation of oocytes has contributed to fertility preservation...
March 26, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29580824/esr2-regulates-granulosa-cell-genes-essential-for-follicle-maturation-and-ovulation
#13
Vincentaben Khristi, V Praveen Chakravarthi, Prabhakar Singh, Subhra Ghosh, Archit Pramanik, Anamika Ratri, Shaon Borosha, Katherine F Roby, Michael W Wolfe, M A Karim Rumi
Estrogen receptor 2 (ESR2) plays a critical role in folliculogenesis and ovulation. Disruption of ESR2-function in the rats results in female infertility due to failure of ovulation. Ovulation failure occurred in two distinct rat models, a null mutant and a DNA binding domain (DBD) mutant of ESR2, indicating that transcriptional regulation by ESR2 is indispensable for ovulation. To define the regulatory role of ESR2 in preovulatory follicular maturation and ovulation, we investigated ovarian responsiveness to exogenous gonadotropins in prepubertal females...
March 23, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29574643/effects-of-monoterpenes-on-mortality-growth-fecundity-and-ovarian-development-of-bactrocera-zonata-saunders-diptera-tephritidae
#14
Abdelaziz M El-Minshawy, Samir A M Abdelgaleil, Gadelhak G Gadelhak, Mohamed A Al-Eryan, Rafiaa A Rabab
The peach fruit fly (PFF), Bactrocera zonata, is a serious insect pest infesting fruits and vegetables. The insecticidal activity of three monoterpenes, namely, (R)-camphor, (R)-carvone, and (1R,2S,5R)-menthol, was evaluated on the second-instar larvae of B. zonata. In addition, the latent effects of monoterpenes on pupation, adult emergence, deformation, oviposition, adult longevity, and ovarian development were also examined. The three tested monoterpenes showed pronounced insecticidal activity against B...
March 25, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29567538/current-approaches-for-the-treatment-of-premature-ovarian-failure-with-stem-cell-therapy
#15
REVIEW
Golshan Sheikhansari, Leili Aghebati-Maleki, Mohammad Nouri, Farhad Jadidi-Niaragh, Mehdi Yousefi
One of the common disorders found in women is premature ovarian failure (POF). Recently some studies have explained premature ovarian insufficiency (POI). The causes of it are unknown although various types of study have been done. The most common causes such as genetic and autoimmune conditions can have a role in POF and can lead to infertility. Some characterization of POF are hypo-oestrogenism (estrogen deficiency), increased gonadotropin level and most importantly amenorrhea. The main purpose of this review is to describe the cause and treatment of POF, especially stem cell therapy proposed in previous studies...
March 19, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29556332/biological-function-of-ribosomal-protein-l10-on-cell-behavior-in-human-epithelial-ovarian-cancer
#16
Jimin Shi, Lingyun Zhang, Daibing Zhou, Jinguo Zhang, Qunbo Lin, Wencai Guan, Jihong Zhang, Weimin Ren, Guoxiong Xu
Ribosomal protein L10 (RPL10) is one of large ribosomal proteins and plays a role in Wilms' tumor and premature ovarian failure. However, the function of RPL10 in human epithelial ovarian cancer (EOC) remains unknown. The purpose of this study was to examine the expression level and function of RPL10 in EOC. RPL10 protein expression was detected by immunohistochemistry and Western blot. The association RPL10 expression with clinical features was analyzed. Loss-of-function and gain-of-function approaches were applied in cellular assays, including cell viability, migration, invasion, and apoptosis...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29555319/fertility-and-infertility-definition-and-epidemiology
#17
REVIEW
Vander Borght Mélodie, Wyns Christine
Infertility is a disease characterized by the failure to establish a clinical pregnancy after 12 months of regular and unprotected sexual intercourse. It is estimated to affect between 8 and 12% of reproductive-aged couples worldwide. Males are found to be solely responsible for 20-30% of infertility cases but contribute to 50% of cases overall. Secondary infertility is the most common form of female infertility around the globe, often due to reproductive tract infections. The three major factors influencing the spontaneous probability of conception are the time of unwanted non-conception, the age of the female partner and the disease-related infertility...
March 16, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29550339/-management-of-endometriosis-cngof-has-practice-guidelines-short-version
#18
P Collinet, X Fritel, C Revel-Delhom, M Ballester, P A Bolze, B Borghese, N Bornsztein, J Boujenah, N Bourdel, T Brillac, N Chabbert-Buffet, C Chauffour, N Clary, J Cohen, C Decanter, A Denouël, G Dubernard, A Fauconnier, H Fernandez, T Gauthier, F Golfier, C Huchon, G Legendre, J Loriau, E Mathieu-d'Argent, B Merlot, J Niro, P Panel, P Paparel, C A Philip, S Ploteau, C Poncelet, B Rabischong, H Roman, C Rubod, P Santulli, M Sauvan, I Thomassin-Naggara, A Torre, J M Wattier, C Yazbeck, M Canis
First-line investigations to diagnose endometriosis are clinical examination and pelvic ultrasound. Second-line investigations include pelvic examination performed by a referent clinician, transvaginal ultrasound performed by a referent, and pelvic MRI. It is recommended to treat endometriosis when it is symptomatic. First-line hormonal treatments recommended for the management of painful endometriosis are combined hormonal contraceptives or levonorgestrel 52mg IUD. There is no evidence to recommend systematic preoperative hormonal therapy for the unique purpose of preventing the risk of surgical complications or facilitating surgery...
March 14, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29546669/transplantation-of-uc-mscs-on-collagen-scaffold-activates-follicles-in-dormant-ovaries-of-pof-patients-with-long-history-of-infertility
#19
Lijun Ding, Guijun Yan, Bin Wang, Lu Xu, Yan Gu, Tong Ru, Xiaoying Cui, Lei Lei, Jingyu Liu, Xiaoqiang Sheng, Bin Wang, Chunxue Zhang, Yanjun Yang, Ruiwei Jiang, Jianjun Zhou, Na Kong, Feifei Lu, Huaijun Zhou, Yannan Zhao, Bing Chen, Yali Hu, Jianwu Dai, Haixiang Sun
Premature ovarian failure (POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study, umbilical cord mesenchymal stem cells on a collagen scaffold (collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles...
March 13, 2018: Science China. Life Sciences
https://www.readbyqxmd.com/read/29546343/ovarian-function-recovery-during-anastrozole-in-breast-cancer-patients-with-chemotherapy-induced-ovarian-function-failure
#20
Irene E G van Hellemond, Ingeborg J H Vriens, Petronella G M Peer, Astrid C P Swinkels, Carolien H Smorenburg, Caroline M Seynaeve, Maurice J C van der Sangen, Judith R Kroep, Hiltje de Graaf, Aafke H Honkoop, Frans L G Erdkamp, Franchette W P J van den Berkmortel, Jos J E M Kitzen, Maaike de Boer, Wïlfred K de Roos, Sabine C Linn, Alexander L T Imholz, Vivianne C G Tjan-Heijnen
Background: Aromatase inhibitors (AIs) are given as adjuvant therapy for hormone receptor-positive breast cancer in postmenopausal women, also to those with chemotherapy-induced ovarian function failure. The current analysis reports on endocrine data of patients with chemotherapy-induced ovarian function failure who were included in the phase III DATA study assessing different durations of adjuvant anastrozole after tamoxifen. Methods: We identified all patients with chemotherapy-induced ovarian function failure...
December 1, 2017: Journal of the National Cancer Institute
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