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Ovarian failure

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https://www.readbyqxmd.com/read/28076512/mutation-analysis-of-nanos3-in-brazilian-women-with-primary-ovarian-failure
#1
Braian Lucas A Sousa, Mirian Yumie Nishi, Mariza Gerdulo Santos, Vinicius Nahime Brito, Sorahia Domenice, Berenice B Mendonca
OBJECTIVES: Primary ovarian failure is a rare disorder, and approximately 90% of cases are of unknown etiology. The aim of this study was to search for mutations in NANOS3, a gene that was recently related to the etiology of primary ovarian failure, in a group of Brazilian women. METHODS: We screened for NANOS3 DNA variants in 30 consecutive women who were previously diagnosed with primary ovarian failure, of unknown etiology and compared the results with those from 185 women with normal fertility...
December 1, 2016: Clinics
https://www.readbyqxmd.com/read/28076330/the-correlation-of-age-with-chemotherapy-induced-ovarian-function-failure-in-breast-cancer-patients
#2
Ingeborg J H Vriens, Ashley J R De Bie, Maureen J B Aarts, Maaike de Boer, Irene E G van Hellemond, Joyce H E Roijen, Ron J T van Golde, Adri C Voogd, Vivianne C G Tjan-Heijnen
PURPOSE: To assess the incidence of chemotherapy-induced ovarian function failure (COFF) based on estradiol and follicle stimulating hormone (FSH) monitoring in premenopausal women with hormone-receptor positive breast cancer treated with second and third generation (neo-)adjuvant chemotherapy. RESULTS: We identified 115 eligible women. Two years after start of chemotherapy, COFF was significantly more often present in women ≥ 40 years (85.6%) as compared to women < 40 years (8...
January 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28074124/involvement-of-blood-mononuclear-cells-in-the-infertility-age-associated-diseases-and-cancer-treatment
#3
REVIEW
Antonin Bukovsky
Blood mononuclear cells consist of T cells and monocyte derived cells. Beside immunity, the blood mononuclear cells belong to the complex tissue control system (TCS), where they exhibit morphostatic function by stimulating proliferation of tissue stem cells followed by cellular differentiation, that is stopped after attaining the proper functional stage, which differs among various tissue types. Therefore, the term immune and morphostatic system (IMS) should be implied. The TCS-mediated morphostasis also consists of vascular pericytes controlled by autonomic innervation, which is regulating the quantity of distinct tissues in vivo...
December 26, 2016: World Journal of Stem Cells
https://www.readbyqxmd.com/read/28070710/the-accumulation-of-vitrified-oocytes-is-a-strategy-to-increase-the-number-of-euploid-available-blastocysts-for-transfer-after-preimplantation-genetic-testing
#4
Sandrine Chamayou, Maria Sicali, Carmelita Alecci, Carmen Ragolia, Annalisa Liprino, Daniela Nibali, Giorgia Storaci, Antonietta Cardea, Antonino Guglielmino
PURPOSE: In a preimplantation genetic diagnosis for aneuploidy (PGD-A) program, the more embryos available for biopsy, consequently increases the chances of obtaining euploid embryos to transfer. The aim was to increase the number of viable euploid blastocysts in patients undergoing PGD-A using fresh oocytes together with previously accumulated vitrified oocytes. METHODS: Sixty-nine patients with normal ovarian reserve underwent PGD-A for repeated implantation failure or recurrent pregnancy loss indication...
January 9, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28062019/care-delivery-patterns-processes-and-outcomes-for-primary-ovarian-cancer-surgery-a-population-based-review-using-a-national-administrative-database
#5
Saad Shakeel, Laurie Elit, Noori Akhtar-Danesh, Laura Schneider, Christian Finley
OBJECTIVES: In this pan-Canadian study, we sought to elucidate the current state of surgical care for primary ovarian cancers and factors influencing selected short-term outcomes; these were in-hospital mortality (IHM), major complications (MCs), failure-to-rescue (FTR), and hospital length of stay (LOS). METHODS: We created a population cohort using inpatient admission records from the Canadian Institute of Health Information data set (2004-2012). Multilevel logistic regression and flexible parametric survival analyses, adjusted for hospital clustering effect, were conducted to determine the effect of patient-specific factors (i...
January 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28060142/the-importance-of-appendectomy-in-surgery-for-mucinous-adenocarcinoma-of-the-ovary
#6
Mikkel Rosendahl, Laura Amalie Haueberg Oester, Claus Kim Høgdall
OBJECTIVE: The aim of this study was to assess the importance of appendectomy during surgery for mucinous ovarian cancer. It can be difficult to distinguish between primary ovarian and primary appendiceal cancers clinically, histologically, and immunohistochemically. Removal of the appendix may facilitate differential diagnosis, improve staging, and possibly increase 5-year survival but may also be associated with increased postsurgical morbidity. In the largest population published to date, we analyze and discuss these matters...
January 4, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28056551/hepatitis-b-x-interacting-protein-promotes-cisplatin-resistance-and-regulates-cd147-via-sp1-in-ovarian-cancer
#7
Wei Zou, Xiangdong Ma, Hong Yang, Wei Hua, Biliang Chen, Guoqing Cai
Ovarian cancer is the highest mortality rate of all female reproductive malignancies. Drug resistance is a major cause of treatment failure in malignant tumors. Hepatitis B X-interacting protein acts as an oncoprotein, regulates cell proliferation, and migration in breast cancer. We aimed to investigate the effects and mechanisms of hepatitis B X-interacting protein on resistance to cisplatin in human ovarian cancer cell lines. The mRNA and protein levels of hepatitis B X-interacting protein were detected using RT-PCR and Western blotting in cisplatin-resistant and cisplatin-sensitive tissues, cisplatin-resistant cell lines A2780/CP and SKOV3/CP, and cisplatin-sensitive cell lines A2780 and SKOV3...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28054732/liver-transplantation-is-associated-with-good-clinical-outcome-in-patients-with-active-tuberculosis-and-acute-liver-failure-due-to-anti-tubercular-treatment
#8
REVIEW
Michele Bartoletti, Giulia Martelli, Sara Tedeschi, Mariacristina Morelli, Valentine Bertuzzo, Marina Tadolini, Paolo Pianta, Francesco Cristini, Maddalena Giannella, Russell E Lewis, Antonio D Pinna, Pierluigi Viale
BACKGROUND: Active tuberculosis (TB) is commonly considered a contraindication for liver transplantation (LT). However, in patients with TB who develop acute liver failure (ALF) due to toxicity induced by anti-tubercular treatment (ATT), LT could be the only opportunity. The aim of this study was to evaluate the feasibility of LT in this scenario. METHODS: We described 2 cases and comprehensively reviewed the literature finding 26 cases of LT performed in patients having a concomitant active TB and liver failure secondary to ATT toxicity...
January 5, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28049703/pathway-structured-predictive-model-for-cancer-survival-prediction-a-two-stage-approach
#9
Xinyan Zhang, Yan Li, Tomi Akinyemiju, Akinyemi I Ojesina, Phillip Buckhaults, Nianjun Liu, Bo Xu, Nengjun Yi
Heterogeneity in terms of tumor characteristics, prognosis, and survival among cancer patients has been a persistent problem for many decades. Currently, prognosis and outcome predictions are made based on clinical factors and/or by incorporating molecular profiling data. However, inaccurate prognosis and prediction may result by using only clinical or molecular information directly. One of the main shortcomings of past studies is the failure to incorporate prior biological information into the predictive model, given strong evidence of the pathway-based genetic nature of cancer, i...
January 2017: Genetics
https://www.readbyqxmd.com/read/28049501/the-abnormal-expression-of-oxytocin-receptors-in-the-uterine-junctional-zone-in-women-with-endometriosis
#10
Miaomaio Huang, Xuqing Li, Peipei Guo, Zhaojuan Yu, Yuting Xu, Zhaolian Wei
BACKGROUND: The junctional zone (JZ), also called as the endometrial-myometrial junction, is related to peristaltic-like movements in the non-pregnant uterus. Hyperperistalsis and dysperistalsis of uterus constructions might underlie many important disorders such as dysmenorrhea, infertility, endometriosis, implantation failure. The major proteins for uterine contraction of the non-pregnant uterus may be Oxytocin (OT) and oxytocin receptor (OTR). The objective of this study was to inspect the expression of OTR in isthmic and mid-fundal parts of the uterine junctional zone at different stages of the follicular cycle in patients with and without endometriosis...
January 3, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28032338/short-report-sf1-and-spleen-development-new-heterozygous-mutation-literature-review-and-consequences-for-nr5a1-mutated-patient-s-management
#11
Cindy Colson, Estelle Aubry, Maryse Cartigny, Amélie-Anne Rémy, Hélène Franquet, Xavier Leroy, Géraldine Kéchid, Christine Lefèvre, Rémi Besson, Martine Cools, Anne Françoise Spinoit, Charles Sultan, Sylvie Manouvrier, Pascal Philibert, Jamal Ghoumid
Steroidogenic factor 1 (encoded by SF1/NR5A1) is a transcription factor with multiple target genes involved in the development and function of multiple steroidogenic and non-steroidogenic tissues. NR5A1 mutations lead to several phenotypes, including sex reversal, spermatogenesis failure, premature ovarian failure and adrenocortical insufficiency. The implication of NR5A1 mutations in spleen development anomalies was recently highlighted. We provide new evidence of this involvement, describing a novel heterozygous nonsense NR5A1 mutation in a 46,XY-DSD with polysplenia female proband and her father, who had hypospadias and asplenia...
December 29, 2016: Clinical Genetics
https://www.readbyqxmd.com/read/28028909/regulation-of-injury-induced-ovarian-regeneration-by-activation-of-oogonial-stem-cells
#12
Piril Erler, Alexandra Sweeney, James R Monaghan
Some animals have the ability to generate large numbers of oocytes throughout life. This raises the question whether persistent adult germline stem cell populations drive continuous oogenesis and whether they are capable of mounting a regenerative response after injury. Here we demonstrate the presence of adult oogonial stem cells (OSCs) in the adult axolotl salamander ovary and show that ovarian injury induces OSC activation and functional regeneration of the ovaries to reproductive capability. Cells that have morphological similarities to germ cells were identified in the developing and adult ovaries via histological analysis...
January 2017: Stem Cells
https://www.readbyqxmd.com/read/28011097/hemostasis-during-ovarian-cystectomy-a-systematic-review-of-the-impact-of-suturing-versus-surgical-energy-on-ovarian-function
#13
REVIEW
Ann Peters, Noah B Rindos, Ted Lee
This systematic review compares the effect of suturing and surgical energy utilized for hemostasis during ovarian cystectomies on ovarian function. A search of the Scopus, Embase, and PubMed databases was conducted through December 1(st) 2016 for prospective and retrospective trials as well as Randomized Controlled Trials (RCTs) that analyzed ovarian function following ovarian cystectomies where hemostasis was obtained using suturing vs. surgical energy. Of the twenty-five studies identified, twelve studies, with a total of 1,133 subjects, met the criteria and were included in this review...
December 21, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28006769/is-menstruation-or-the-serum-hormone-level-a-useful-predictor-for-live-birth-after-gonadotropin-releasing-hormone-agonist-during-chemotherapy-in-young-breast-cancer-patients
#14
Dong-Yun Lee, DooSeok Choi
AIMS: The study aimed to investigate whether changes in menstruation or hormone levels are useful parameters to assess the efficacy of gonadotropin-releasing hormone (GnRH) agonist co-treatment with chemotherapy. METHODS: This study included women in their reproductive age diagnosed with breast cancer and who received GnRH agonist during chemotherapy for ovarian protection. Women with treatment failure (follicle-stimulating hormone (FSH) level >20 mIU/mL after at least 12 months and failure for becoming pregnant; n = 16) or with treatment success (becoming pregnant spontaneously and having a live birth; n = 20) were selected, and clinical characteristics, resumption of menstruation, and changes in hormone profiles were compared...
December 23, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27993358/involvement-of-matrix-metalloproteinases-and-their-inhibitors-in-bovine-cystic-ovarian-disease
#15
M B Peralta, M E Baravalle, E M Belotti, A F Stassi, N R Salvetti, H H Ortega, F Rey, M M L Velázquez
The most important regulators of tissue remodelling during ovarian follicular growth, development, ovulation and atresia are gonadotropins, steroid hormones, growth factors and different proteolytic enzymes. Matrix metalloproteinases (MMPs) such as collagenase or gelatinase (i.e. MMP-1, -8, -2 and -9) and associated tissue inhibitors of metalloproteinases (TIMP-1, -2, -3 and -4) control connective tissue remodelling during follicular rupture. In this study, we hypothesized that an imbalance in the MMP-TIMP system may be an intra-ovarian component that contributes to the pathogenesis of cystic ovarian disease (COD) in cows...
December 16, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27990249/sex-differences-in-sympathetic-innervation-and-browning-of-white-adipose-tissue-of-mice
#16
Sang-Nam Kim, Young-Suk Jung, Hyun-Jung Kwon, Je Kyung Seong, James G Granneman, Yun-Hee Lee
BACKGROUND: The higher prevalence of obesity-related metabolic disease in males suggests that female sex hormones provide protective mechanisms against the pathogenesis of metabolic syndrome. Because browning of white adipose tissue (WAT) is protective against obesity-related metabolic disease, we examined sex differences in β3-adrenergic remodeling of WAT in mice. METHODS: Effects of the β3-adrenergic receptor agonist CL316,243 (CL) on browning of white adipose tissue were investigated in male and female C57BL mice...
2016: Biology of Sex Differences
https://www.readbyqxmd.com/read/27989800/next-generation-sequencing-identifies-abnormal-y-chromosome-and-candidate-causal-variants-in-premature-ovarian-failure-patients
#17
Yujung Lee, Changshin Kim, YoungJoon Park, Jung-A Pyun, KyuBum Kwack
Premature ovarian failure (POF) is characterized by heterogeneous genetic causes such as chromosomal abnormalities and variants in causal genes. Recently, development of techniques made next generation sequencing (NGS) possible to detect genome wide variants including chromosomal abnormalities. Among 37 Korean POF patients, XY karyotype with distal part deletions of Y chromosome, Yp11.32-31 and Yp12 end part, was observed in two patients through NGS. Six deleterious variants in POF genes were also detected which might explain the pathogenesis of POF with abnormalities in the sex chromosomes...
October 29, 2016: Genomics
https://www.readbyqxmd.com/read/27988392/operative-outcomes-of-opportunistic-bilateral-salpingectomy-at-the-time-of-benign-hysterectomy-in-low-risk-premenopausal-women-a-systematic-review
#18
REVIEW
Rosanne M Kho, Mary Ellen Wechter
Opportunistic salpingectomy (OBS) is gaining momentum as a potential strategy for preventing epithelial ovarian cancer (EOC). OBS has been associated with a 40-65% decrease in the incidence of EOC when performed at the time of benign hysterectomy in patients at population-level risk for EOC. Current data suggests minimal disadvantage or "cost" to the patient and system from this practice in terms of estimated blood loss (EBL), operative time, length of hospital stay, ovarian reserve depletion, and complications attributable to OBS...
December 14, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27981878/xenogeneic-decellularized-scaffold-a-novel-platform-for-ovary-regeneration
#19
Wen-Yue Liu, Shi-Gang Lin, Ru-Yi Zhuo, Yuan-Yuan Xie, Wei Pan, Xian-Feng Lin, Fei-Xia Shen
Women younger than 40 years may face early menopause because of premature ovarian failure (POF). The cause of POF can be idiopathic or iatrogenic, especially the cancer-induced oophorectomy and chemo- or radiation therapy. The current treatments, including hormone replacement therapy (HRT) and cryopreservation techniques, have increased risk of ovarian cancer and may reintroduce malignant cells after autografting. Decellularization technique has been regarded as a novel regenerative medicine strategy for organ replacement, wherein the living cells of an organ are removed, leaving the extracellular matrix (ECM) for cellular seeding...
January 10, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/27966219/oncofertility-program-implementation-increases-access-to-fertility-preservation-options-and-assisted-reproductive-procedures-for-breast-cancer-patients
#20
Joceline V Vu, Natalia C Llarena, Samantha L Estevez, Molly B Moravek, Jacqueline S Jeruss
BACKGROUND AND OBJECTIVES: Breast cancer treatment can cause premature ovarian failure, yet the majority of young cancer patients do not receive adequate education about treatment effects before initiating chemotherapy. We studied the impact of an oncofertility program on access to fertility preservation. METHODS: An oncofertility program was initiated to foster collaboration between oncologists and reproductive endocrinologists, and to help increase access to fertility preservation...
December 14, 2016: Journal of Surgical Oncology
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