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https://www.readbyqxmd.com/read/28814269/applied-swarm-based-medicine-collecting-decision-trees-for-patterns-of-algorithms-analysis
#1
Cédric M Panje, Markus Glatzer, Joscha von Rappard, Christian Rothermundt, Thomas Hundsberger, Valentin Zumstein, Ludwig Plasswilm, Paul Martin Putora
BACKGROUND: The objective consensus methodology has recently been applied in consensus finding in several studies on medical decision-making among clinical experts or guidelines. The main advantages of this method are an automated analysis and comparison of treatment algorithms of the participating centers which can be performed anonymously. METHODS: Based on the experience from completed consensus analyses, the main steps for the successful implementation of the objective consensus methodology were identified and discussed among the main investigators...
August 16, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28812258/chromosomal-flhb1-gene-of-the-alphaproteobacterium-azospirillum-brasilense-sp245-is-essential-for-correct-assembly-of-both-constitutive-polar-flagellum-and-inducible-lateral-flagella
#2
Yulia Filip'echeva, Andrei Shelud'ko, Alexei Prilipov, Elizaveta Telesheva, Dmitry Mokeev, Andrei Burov, Lilia Petrova, Elena Katsy
Azospirillum brasilense has the ability of swimming and swarming motility owing to the work of a constitutive polar flagellum and inducible lateral flagella, respectively. The interplay between these flagellar systems is poorly understood. One of the key elements of the flagellar export apparatus is the protein FlhB. Two predicted flhB genes are present in the genome of A. brasilense Sp245 (accession nos. HE577327-HE577333). Experimental evidence obtained here indicates that the chromosomal coding sequence (CDS) AZOBR_150177 (flhB1) of Sp245 is essential for the production of both types of flagella...
August 15, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/28810146/swarm-intelligence-enhanced-detection-of-non-small-cell-lung-cancer-using-tumor-educated-platelets
#3
Myron G Best, Nik Sol, Sjors G J G In 't Veld, Adrienne Vancura, Mirte Muller, Anna-Larissa N Niemeijer, Aniko V Fejes, Lee-Ann Tjon Kon Fat, Anna E Huis In 't Veld, Cyra Leurs, Tessa Y Le Large, Laura L Meijer, Irsan E Kooi, François Rustenburg, Pepijn Schellen, Heleen Verschueren, Edward Post, Laurine E Wedekind, Jillian Bracht, Michelle Esenkbrink, Leon Wils, Francesca Favaro, Jilian D Schoonhoven, Jihane Tannous, Hanne Meijers-Heijboer, Geert Kazemier, Elisa Giovannetti, Jaap C Reijneveld, Sander Idema, Joep Killestein, Michal Heger, Saskia C de Jager, Rolf T Urbanus, Imo E Hoefer, Gerard Pasterkamp, Christine Mannhalter, Jose Gomez-Arroyo, Harm-Jan Bogaard, David P Noske, W Peter Vandertop, Daan van den Broek, Bauke Ylstra, R Jonas A Nilsson, Pieter Wesseling, Niki Karachaliou, Rafael Rosell, Elizabeth Lee-Lewandrowski, Kent B Lewandrowski, Bakhos A Tannous, Adrianus J de Langen, Egbert F Smit, Michel M van den Heuvel, Thomas Wurdinger
Blood-based liquid biopsies, including tumor-educated blood platelets (TEPs), have emerged as promising biomarker sources for non-invasive detection of cancer. Here we demonstrate that particle-swarm optimization (PSO)-enhanced algorithms enable efficient selection of RNA biomarker panels from platelet RNA-sequencing libraries (n = 779). This resulted in accurate TEP-based detection of early- and late-stage non-small-cell lung cancer (n = 518 late-stage validation cohort, accuracy, 88%; AUC, 0.94; 95% CI, 0...
August 14, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28809745/a-hybrid-active-force-control-of-a-lower-limb-exoskeleton-for-gait-rehabilitation
#4
Zahari Taha, Anwar P P Abdul Majeed, Amar Faiz Zainal Abidin, Mohammed A Hashem Ali, Ismail Mohd Khairuddin, Abdelhakim Deboucha, Mohd Yashim Wong Paul Tze
Owing to the increasing demand for rehabilitation services, robotics have been engaged in addressing the drawbacks of conventional rehabilitation therapy. This paper focuses on the modelling and control of a three-link lower limb exoskeleton for gait rehabilitation that is restricted to the sagittal plane. The exoskeleton that is modelled together with a human lower limb model is subjected to a number of excitations at its joints while performing a joint space trajectory tracking, to investigate the effectiveness of the proposed controller in compensating disturbances...
August 15, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28808442/firefly-mating-algorithm-for-continuous-optimization-problems
#5
Amarita Ritthipakdee, Arit Thammano, Nol Premasathian, Duangjai Jitkongchuen
This paper proposes a swarm intelligence algorithm, called firefly mating algorithm (FMA), for solving continuous optimization problems. FMA uses genetic algorithm as the core of the algorithm. The main feature of the algorithm is a novel mating pair selection method which is inspired by the following 2 mating behaviors of fireflies in nature: (i) the mutual attraction between males and females causes them to mate and (ii) fireflies of both sexes are of the multiple-mating type, mating with multiple opposite sex partners...
2017: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/28808423/in-search-for-pheromone-receptors-certain-members-of-the-odorant-receptor-family-in-the-desert-locust-schistocerca-gregaria-orthoptera-acrididae-are-co-expressed-with-snmp1
#6
Pablo Pregitzer, Xingcong Jiang, Ewald Grosse-Wilde, Heinz Breer, Jürgen Krieger, Joerg Fleischer
Under given environmental conditions, the desert locust (Schistocera gregaria) forms destructive migratory swarms of billions of animals, leading to enormous crop losses in invaded regions. Swarm formation requires massive reproduction as well as aggregation of the animals. Pheromones that are detected via the olfactory system have been reported to control both reproductive and aggregation behavior. However, the molecular basis of pheromone detection in the antennae of Schistocerca gregaria is unknown. As an initial step to disclose pheromone receptors, we sequenced the antennal transcriptome of the desert locust...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28808286/source-and-dynamics-of-a-volcanic-caldera-unrest-campi-flegrei-1983-84
#7
Luca De Siena, Giovanni Chiodini, Giuseppe Vilardo, Edoardo Del Pezzo, Mario Castellano, Simona Colombelli, Nicola Tisato, Guido Ventura
Despite their importance for eruption forecasting the causes of seismic rupture processes during caldera unrest are still poorly reconstructed from seismic images. Seismic source locations and waveform attenuation analyses of earthquakes in the Campi Flegrei area (Southern Italy) during the 1983-1984 unrest have revealed a 4-4.5 km deep NW-SE striking aseismic zone of high attenuation offshore Pozzuoli. The lateral features and the principal axis of the attenuation anomaly correspond to the main source of ground uplift during the unrest...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28807106/developmental-adaptations-of-trypanosome-motility-to-the-tsetse-fly-host-environments-unravel-a-multifaceted-in-vivo-microswimmer-system
#8
Sarah Schuster, Timothy Krüger, Ines Subota, Sina Thusek, Brice Rotureau, Andreas Beilhack, Markus Engstler
The highly motile and versatile protozoan pathogen Trypanosoma brucei undergoes a complex life cycle in the tsetse fly. Here we introduce the host insect as an expedient model environment for microswimmer research, as it allows examination of microbial motion within a diversified, secluded and yet microscopically tractable space. During their week-long journey through the different microenvironments of the fly´s interior organs, the incessantly swimming trypanosomes cross various barriers and confined surroundings, with concurrently occurring major changes of parasite cell architecture...
August 15, 2017: ELife
https://www.readbyqxmd.com/read/28806756/generic-scalable-and-decentralized-fault-detection-for-robot-swarms
#9
Danesh Tarapore, Anders Lyhne Christensen, Jon Timmis
Robot swarms are large-scale multirobot systems with decentralized control which means that each robot acts based only on local perception and on local coordination with neighboring robots. The decentralized approach to control confers number of potential benefits. In particular, inherent scalability and robustness are often highlighted as key distinguishing features of robot swarms compared with systems that rely on traditional approaches to multirobot coordination. It has, however, been shown that swarm robotics systems are not always fault tolerant...
2017: PloS One
https://www.readbyqxmd.com/read/28804018/anti-biofilm-activity-of-a22-s-3-4-dichlorobenzyl-isothiourea-hydrochloride-against-pseudomonas-aeruginosa-influence-on-biofilm-formation-motility-and-bioadhesion
#10
Pauline Cordenonsi Bonez, Grazielle Guidolin Rossi, Jardel Rodrigo Bandeira, Andiara Prates Ramos, Caren Rigon Mizdal, Vanessa Albertina Agertt, Eloísa Salete Segatto Dalla Nora, Márcia Ebling de Souza, Camilla Fillippi Dos Santos Alves, Fallon Siqueira Dos Santos, André Gündel, Rodrigo de Almeida Vaucher, Roberto Christ Vianna Santos, Marli Matiko Anraku de Campos
Bacterial biofilms are involved in various medical infections and for this reason it is of great importance understanding adhesion mechanisms of involved microorganisms is essential to develop new strategies of prevention and control. Different approaches have been used for preventing biofilm related infections in health care settings, such as use of surface coatings agents in medical implants. In this context, is necessary to explore new compounds with anti-biofilm activity. Thus, this study evaluated for the first time the action of A22 against biofilms of Pseudomonas aeruginosa PAO1 strain and multi-resistant clinical isolates on biotic and abiotic surfaces...
August 10, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28802837/development-of-simulation-optimization-methods-for-solving-patient-referral-problems-in-the-hospital-collaboration-environment
#11
Ping-Shun Chen, Ming-Han Lin
This research studied a patient referral problem among multiple cooperative hospitals for sharing imaging services' referrals. The proposed problem consisted of many types of patients and the uncertainty associated with the number of patients of each type, patients' arrival time, and patients' medical operation time, leading to a difficulty in finding solutions due to the uncertain environment. This research used system simulation to construct a model and develop a simulation optimization method, combining the heuristic algorithm (patient referral mechanism) with the particle swarm optimization (PSO) method, to determine a better way to refer patients from one hospital (referring hospital) to another (recipient hospital) to receive certain imaging services...
August 9, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28799945/sediment-transport-modeling-in-deposited-bed-sewers-unified-form-of-may-s-equations-using-the-particle-swarm-optimization-algorithm
#12
Mir Jafar Sadegh Safari, Akbar Shirzad, Mirali Mohammadi
May proposed two dimensionless parameters of transport (η) and mobility (Fs) for self-cleansing design of sewers with deposited bed condition. The relationships between those two parameters were introduced in conditional form for specific ranges of Fs, which makes it difficult to use as a practical tool for sewer design. In this study, using the same experimental data used by May and employing the particle swarm optimization algorithm, a unified equation is recommended based on η and Fs. The developed model is compared with original May relationships as well as corresponding models available in the literature...
August 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28799693/the-small-rna-real-a-novel-regulatory-element-embedded-in-the-pseudomonas-aeruginosa-quorum-sensing-networks
#13
Sara Carloni, Raffaella Macchi, Sara Sattin, Silvia Ferrara, Giovanni Bertoni
The small RNA ReaL of the opportunistic pathogen Pseudomonas aeruginosa has been characterized. Our results indicate that ReaL contributes to P. aeruginosa virulence. In the Galleria mellonella infection model, reaL gene deletion resulted in decreased virulence, while ReaL overexpression resulted in a hyper-virulent phenotype. We also demonstrate that ReaL is embedded in the P. aeruginosa quorum sensing (QS) with the role of linking las to pqs systems. We show that ReaL is negatively regulated by the las regulator LasR and impacts positively the synthesis of the pqs quinolone signal PQS by a positive post-transcriptional effect on the pqsC gene...
August 11, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28792909/set-based-discrete-particle-swarm-optimization-based-on-decomposition-for-permutation-based-multiobjective-combinatorial-optimization-problems
#14
Xue Yu, Wei-Neng Chen, Tianlong Gu, Huaxiang Zhang, Huaqiang Yuan, Sam Kwong, Jun Zhang
This paper studies a specific class of multiobjective combinatorial optimization problems (MOCOPs), namely the permutation-based MOCOPs. Many commonly seen MOCOPs, e.g., multiobjective traveling salesman problem (MOTSP), multiobjective project scheduling problem (MOPSP), belong to this problem class and they can be very different. However, as the permutation-based MOCOPs share the inherent similarity that the structure of their search space is usually in the shape of a permutation tree, this paper proposes a generic multiobjective set-based particle swarm optimization methodology based on decomposition, termed MS-PSO/D...
August 7, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28791170/fire-ants-perpetually-rebuild-sinking-towers
#15
Sulisay Phonekeo, Nathan Mlot, Daria Monaenkova, David L Hu, Craig Tovey
In the aftermath of a flood, fire ants, Solenopsis invicta, cluster into temporary encampments. The encampments can contain hundreds of thousands of ants and reach over 30 ants high. How do ants build such tall structures without being crushed? In this combined experimental and theoretical study, we investigate the shape and rate of construction of ant towers around a central support. The towers are bell shaped, consistent with towers of constant strength such as the Eiffel tower, where each element bears an equal load...
July 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28790346/gaussian-network-model-can-be-enhanced-by-combining-solvent-accessibility-in-proteins
#16
Hua Zhang, Tao Jiang, Guogen Shan, Shiqi Xu, Yujie Song
Gaussian network model (GNM), regarded as the simplest and most representative coarse-grained model, has been widely adopted to analyze and reveal protein dynamics and functions. Designing a variation of the classical GNM, by defining a new Kirchhoff matrix, is the way to improve the residue flexibility modeling. We combined information arising from local relative solvent accessibility (RSA) between two residues into the Kirchhoff matrix of the parameter-free GNM. The undetermined parameters in the new Kirchhoff matrix were estimated by using particle swarm optimization...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28782279/biosynthesis-of-the-antimicrobial-cyclic-lipopeptides-nunamycin-and-nunapeptin-by-pseudomonas-fluorescens-strain-in5-is-regulated-by-the-luxr-type-transcriptional-regulator-nunf
#17
Rosanna C Hennessy, Christopher B W Phippen, Kristian F Nielsen, Stefan Olsson, Peter Stougaard
Nunamycin and nunapeptin are two antimicrobial cyclic lipopeptides (CLPs) produced by Pseudomonas fluorescens In5 and synthesized by nonribosomal synthetases (NRPS) located on two gene clusters designated the nun-nup regulon. Organization of the regulon is similar to clusters found in other CLP-producing pseudomonads except for the border regions where putative LuxR-type regulators are located. This study focuses on understanding the regulatory role of the LuxR-type-encoding gene nunF in CLP production of P...
August 6, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28780591/revealing-strategies-of-quorum-sensing-in-azospirillum-brasilense-strains-ab-v5-and-ab-v6
#18
Josiane Fukami, Julia Laura Fernandes Abrantes, Pablo Del Cerro, Marco Antonio Nogueira, Francisco Javier Ollero, Manuel Megías, Mariangela Hungria
Azospirillum brasilense is an important plant-growth promoting bacterium (PGPB) that requires several critical steps for root colonization, including biofilm and exopolysaccharide (EPS) synthesis and cell motility. In several bacteria these mechanisms are mediated by quorum sensing (QS) systems that regulate the expression of specific genes mediated by the autoinducers N-acyl-homoserine lactones (AHLs). We investigated QS mechanisms in strains Ab-V5 and Ab-V6 of A. brasilense, which are broadly used in commercial inoculants in Brazil...
August 5, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28776030/urbanization-induced-population-migration-has-reduced-ambient-pm2-5-concentrations-in-china
#19
Huizhong Shen, Shu Tao, Yilin Chen, Philippe Ciais, Burak Güneralp, Muye Ru, Qirui Zhong, Xiao Yun, Xi Zhu, Tianbo Huang, Wei Tao, Yuanchen Chen, Bengang Li, Xilong Wang, Wenxin Liu, Junfeng Liu, Shuqing Zhao
Direct residential and transportation energy consumption (RTC) contributes significantly to ambient fine particulate matter with a diameter smaller than 2.5 μm (PM2.5) in China. During massive rural-urban migration, population and pollutant emissions from RTC have evolved in terms of magnitude and geographic distribution, which was thought to worsen PM2.5 levels in cities but has not been quantitatively addressed. We quantify the temporal trends and spatial patterns of migration to cities and evaluate their associated pollutant emissions from RTC and subsequent health impact from 1980 to 2030...
July 2017: Science Advances
https://www.readbyqxmd.com/read/28774023/pressure-induced-phase-transition-and-mechanical-properties-of-mg%C3%A2-sr-intermetallics
#20
Haiyan Yan, Xingming Han, Baobing Zheng
A pressure-induced phase transition of Mg₂Sr intermetallics from the low-pressure C14-type phase to an orthorhombic phase (space group Cmcm, Z = 4) at a high pressure of 21.0 GPa was firstly predicted using first-principles calculations combined with unbiased swarm structure searching techniques. The phase transition was identified as a first-order nature with a volume drop of 4.7%, driven by the softening of elastic behavior at high pressure. Further phonon calculations indicate that the newly predicted orthorhombic phase is dynamically stable at high pressure and ambient pressure...
November 8, 2016: Materials
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