Dominique Fournelle, Fatima Mostefai, Elsa Brunet-Ratnasingham, Raphaël Poujol, Jean-Christophe Grenier, José Héctor Gálvez, Amélie Pagliuzza, Inès Levade, Sandrine Moreira, Mehdi Benlarbi, Guillaume Beaudoin-Bussières, Gabrielle Gendron-Lepage, Catherine Bourassa, Alexandra Tauzin, Simon Grandjean Lapierre, Nicolas Chomont, Andrés Finzi, Daniel E Kaufmann, Morgan Craig, Julie G Hussin
Throughout the SARS-CoV-2 pandemic, several variants of concern (VOCs) have been identified, many of which share recurrent mutations in the spike glycoprotein's receptor-binding domain (RBD). This region coincides with known epitopes and can therefore have an impact on immune escape. Protracted infections in immunosuppressed patients have been hypothesized to lead to an enrichment of such mutations and therefore drive evolution towards VOCs. Here, we present the case of an immunosuppressed patient that developed distinct populations with immune escape mutations throughout the course of their infection...
February 23, 2024: Viruses