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https://www.readbyqxmd.com/read/28638976/lilrb-receptor-mediated-regulation-of-myeloid-cell-maturation-and-function
#1
REVIEW
William van der Touw, Hui-Ming Chen, Ping-Ying Pan, Shu-Hsia Chen
The leukocyte immunoglobulin-like receptor (LILR) family comprises a set of paired immunomodulatory receptors expressed among human myeloid and lymphocyte cell populations. While six members of LILR subfamily A (LILRA) associate with membrane adaptors to signal via immunoreceptor tyrosine-based activating motifs (ITAM), LILR subfamily B (LILRB) members signal via multiple cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIM). Ligand specificity of some LILR family members has been studied in detail, but new perspective into the immunoregulatory aspects of this receptor family in human myeloid cells has been limited...
June 21, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28594961/pirb-regulates-asymmetries-in-hippocampal-circuitry
#2
Hikari Ukai, Aiko Kawahara, Keiko Hirayama, Matthew Julian Case, Shotaro Aino, Masahiro Miyabe, Ken Wakita, Ryohei Oogi, Michiyo Kasayuki, Shihomi Kawashima, Shunichi Sugimoto, Kanako Chikamatsu, Noritaka Nitta, Tsuneyuki Koga, Ryuichi Shigemoto, Toshiyuki Takai, Isao Ito
Left-right asymmetry is a fundamental feature of higher-order brain structure; however, the molecular basis of brain asymmetry remains unclear. We recently identified structural and functional asymmetries in mouse hippocampal circuitry that result from the asymmetrical distribution of two distinct populations of pyramidal cell synapses that differ in the density of the NMDA receptor subunit GluRε2 (also known as NR2B, GRIN2B or GluN2B). By examining the synaptic distribution of ε2 subunits, we previously found that β2-microglobulin-deficient mice, which lack cell surface expression of the vast majority of major histocompatibility complex class I (MHCI) proteins, do not exhibit circuit asymmetry...
2017: PloS One
https://www.readbyqxmd.com/read/28441398/the-effects-of-immune-protein-cd3%C3%AE-development-and-degeneration-of-retinal-neurons-after-optic-nerve-injury
#3
Tao He, Xavier Mortensen, Ping Wang, Ning Tian
Major histocompatibility complex (MHC) class I molecules and their receptors play fundamental roles in neuronal death during diseases. T-cell receptors (TCR) function as MHCI receptor on T-cells and both MHCI and a key component of TCR, CD3ζ, are expressed by mouse retinal ganglion cells (RGCs) and displaced amacrine cells. Mutation of these molecules compromises the development of RGCs. We investigated whether CD3ζ regulates the development and degeneration of amacrine cells after RGC death. Surprisingly, mutation of CD3ζ not only impairs the proper development of amacrine cells expressing CD3ζ but also those not expressing CD3ζ...
2017: PloS One
https://www.readbyqxmd.com/read/28438456/pirab-protein-from-xenorhabdus-nematophila-hb310-exhibits-a-binary-toxin-with-insecticidal-activity-and-cytotoxicity-in-galleria-mellonella
#4
Qing Yang, Jie Zhang, Tianhui Li, Shen Liu, Ping Song, Ziyan Nangong, Qinying Wang
PirAB (Photorhabdus insect-related proteins, PirAB) toxin was initially found in the Photorhabdus luminescens TT01 strain and has been shown to be a binary toxin with high insecticidal activity. Based on GenBank data, this gene was also found in the Xenorhabdus nematophila genome sequence. The predicted amino acid sequence of pirA and pirB in the genome of X. nematophila showed 51% and 50% identity with those gene sequences from P. luminescens. The purpose of this experiment is to identify the relevant information for this toxin gene in X...
April 21, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28432099/acute-hepatopancreatic-necrosis-disease-ahpnd-causing-vibrio-parahaemolyticus-strains-maintain-an-antibacterial-type-vi-secretion-system-with-versatile-effector-repertoires
#5
Peng Li, Lisa N Kinch, Ann Ray, Ankur B Dalia, Qian Cong, Linda M Nunan, Andrew Camilli, Nick V Grishin, Dor Salomon, Kim Orth
Acute hepatopancreatic necrosis disease (AHPND) is a newly emerging shrimp disease that has severely damaged the global shrimp industry. AHPND is caused by toxic strains of Vibrio parahaemolyticus (V. parahaemolyticus) that have acquired a "selfish plasmid" encoding the deadly binary toxins PirA(vp)/PirB(vp) To better understand the repertoire of virulence factors in AHPND-causing V. parahaemolyticus, we conducted a comparative analysis using genome sequences of the clinical strain RIMD2210633, environmental non-AHPND and toxic AHPND isolates of V...
April 21, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28404482/plasmid-dynamics-in-vibrio-parahaemolyticus-strains-related-to-shrimp-acute-hepatopancreatic-necrosis-syndrome-ahpns
#6
Chonchanok Theethakaew, Shota Nakamura, Daisuke Motooka, Shigeaki Matsuda, Toshio Kodama, Kaknokrat Chonsin, Orasa Suthienkul, Tetsuya Iida
Vibrio parahaemolyticus is a causative agent of acute hapatopancreatic necrosis syndrome (AHPNS) which causes early mortality in white shrimp. Emergence of AHPNS has caused tremendous economic loss for aquaculture industry particularly in Asia since 2010. Previous studies reported that strains causing AHPNS harbor a 69-kb plasmid with possession of virulence genes, pirA and pirB. However, genetic variation of the 69-kb plasmid among AHPNS related strains has not been investigated. This study aimed to analyze genetic composition and diversity of the 69-kb plasmid in strains isolated from shrimps affected by AHPNS...
April 9, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28315758/tat-pep-a-novel-blocker-of-pirb-enhances-the-recovery-of-cognitive-function-in-mice-after-transient-global-cerebral-ischemia
#7
Liya Li, Bin Deng, Shuang Li, Zhaoyu Liu, Tao Jiang, Zhaoyang Xiao, Qiang Wang
Neuronal damage and axonal regeneration inhibition are the main reasons to poor functional recovery after ischemia. Nogo-A signals inhibit axon outgrowth through the PirB receptor after ischemic reperfusion injury in central nervous system. We use TAT-PEP, a novel protein which could pass through the blood brain barrier, to block the function of PirB and identify the long-term neurological and behavioral recovery after bilateral common carotid artery occlusion (BCCAO) in mice. We observed that TAT-PEP promoted neuron survival and inhibited neuronal apoptosis...
March 16, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/27987133/tat-pep-enhanced-neurobehavioral-functional-recovery-by-facilitating-axonal-regeneration-and-corticospinal-tract-projection-after-stroke
#8
Bin Deng, Liya Li, Xingchun Gou, Hao Xu, Zhaohua Zhao, Qiang Wang, Lixian Xu
Paired immunoglobulin-like receptor B (PirB) has been identified as a new receptor for myelin-associated inhibitory (MAI) proteins, which may play important role in axonal regeneration and corticospinal tract (CST) projection associated with neurobehavioral function recovery after stroke. Here, we found that the expression of PirB was increased in the cortical penumbra from 1 to 28 days after transient focal cerebral ischemic reperfusion of rats. Then, transactivator of transcription-PirB extracellular peptide (TAT-PEP) was generated that might block the interactions between MAIs and PirB...
December 16, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27966582/electroacupuncture-enhances-rehabilitation-through-mir-181b-targeting-pirb-after-ischemic-stroke
#9
Bin Deng, Fuhai Bai, Heng Zhou, Dandan Zhou, Zhi Ma, Lize Xiong, Qiang Wang
Recent studies have demonstrated microRNAs (miRNAs) and proteins are beneficial to axon regeneration, which may be involved in Electroacupuncture (EA) therapy against stroke. In this study, we aimed to determine the pivotal role of PirB in EA-produced rehabilitation against ischemic stroke; and to screen and investigate the potential miRNAs directly regulating PirB expression. The results showed EA treatment enhanced axon regeneration and new projections from the corticospinal tract at 28 d after cerebral ischemic reperfusion injury of rats...
December 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27823982/angptl8-reverses-established-adriamycin-cardiomyopathy-by-stimulating-adult-cardiac-progenitor-cells
#10
Shuyuan Chen, Jiaxi Chen, Xing-Li Meng, Jin-Song Shen, Jing Huang, Pintong Huang, Zhaoxia Pu, Nathan H McNeill, Paul A Grayburn
Established adriamycin cardiomyopathy is a lethal disease. When congestive heart failure develops, mortality is approximately 50% in a year. It has been known that ANGPTLs has various functions in lipid metabolism, inflammation, cancer cell invasion, hematopoietic stem activity and diabetes. We hypothesized that ANGPTL8 is capable of maintaining heart function by stimulating adult cardiac progenitor cells to initiate myocardial regeneration. We employed UTMD to deliver piggybac transposon plasmids with the human ANGPTL8 gene to the liver of rats with adriamycin cardiomyopathy...
December 6, 2016: Oncotarget
https://www.readbyqxmd.com/read/27752542/cell-autonomous-regulation-of-dendritic-spine-density-by-pirb
#11
George S Vidal, Maja Djurisic, Kiana Brown, Richard W Sapp, Carla J Shatz
Synapse density on cortical pyramidal neurons is modulated by experience. This process is highest during developmental critical periods, when mechanisms of synaptic plasticity are fully engaged. In mouse visual cortex, the critical period for ocular dominance (OD) plasticity coincides with the developmental pruning of synapses. At this time, mice lacking paired Ig-like receptor B (PirB) have excess numbers of dendritic spines on L5 neurons; these spines persist and are thought to underlie the juvenile-like OD plasticity observed in adulthood...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27749928/correction-mhc-i-and-pirb-upregulation-in-the-central-and-peripheral-nervous-system-following-sciatic-nerve-injury
#12
André Luis Bombeiro, Rodolfo Thomé, Sérgio Luiz Oliveira Nunes, Bárbara Monteiro Moreira, Liana Verinaud, Alexandre Leite Rodrigues de Oliveira
[This corrects the article DOI: 10.1371/journal.pone.0161463.].
2016: PloS One
https://www.readbyqxmd.com/read/27637803/activation-of-lilrb2-signal-pathway-in-temporal-lobe-epilepsy-patients-and-in-a-pilocarpine-induced-epilepsy-model
#13
Jiong Yue, Wei Li, Chao Liang, Bing Chen, Xin Chen, Lukang Wang, Zhenle Zang, Sixun Yu, Shiyong Liu, Song Li, Hui Yang
Temporal lobe epilepsy (TLE) is a frequent form of focal intractable epilepsy in adults, but the specific mechanism underlying the epileptogenesis of TLE is still unknown. Human leukocyte immunoglobulin-like receptor B2 (LILRB2) (the murine homolog gene called paired immunoglobulin-like receptor B, or PirB), participates in the process of synaptic plasticity and neurite growth in the central nervous system (CNS), suggesting a potential role of LILRB2 in epilepsy. However, the expression pattern of LILRB2 and the downstream molecular signal in intractable TLE remains poorly understood...
November 2016: Experimental Neurology
https://www.readbyqxmd.com/read/27570736/draft-genome-sequence-of-pathogenic-bacteria-vibrio-parahaemolyticus-strain-ba94c2-associated-with-acute-hepatopancreatic-necrosis-disease-isolate-from-south-america
#14
Leda Restrepo, Bonny Bayot, Irma Betancourt, Andres Pinzón
Vibrio parahaemolyticus is a pathogenic bacteria which has been associated to the early mortality syndrome (EMS) also known as hepatopancreatic necrosis disease (AHPND) causing high mortality in shrimp farms. Pathogenic strains contain two homologous genes related to insecticidal toxin genes, PirA and PirB, these toxin genes are located on a plasmid contained within the bacteria. Genomic sequences have allowed the finding of two strains with a divergent structure related to the geographic region from where they were found...
September 2016: Genomics Data
https://www.readbyqxmd.com/read/27551751/mhc-i-and-pirb-upregulation-in-the-central-and-peripheral-nervous-system-following-sciatic-nerve-injury
#15
André Luis Bombeiro, Rodolfo Thomé, Sérgio Luiz Oliveira Nunes, Bárbara Monteiro Moreira, Liana Verinaud, Alexandre Leite Rodrigues de Oliveira
Major histocompatibility complex class one (MHC-I) antigen-presenting molecules participate in central nervous system (CNS) synaptic plasticity, as does the paired immunoglobulin-like receptor B (PirB), an MHC-I ligand that can inhibit immune-cells and bind to myelin axon growth inhibitors. Based on the dual roles of both molecules in the immune and nervous systems, we evaluated their expression in the central and peripheral nervous system (PNS) following sciatic nerve injury in mice. Increased PirB and MHC-I protein and gene expression is present in the spinal cord one week after nerve transection, PirB being mostly expressed in the neuropile region...
2016: PloS One
https://www.readbyqxmd.com/read/27522063/virulence-of-acute-hepatopancreatic-necrosis-disease-pirab-like-relies-on-secreted-proteins-not-on-gene-copy-number
#16
S Tinwongger, Y Nochiri, J Thawonsuwan, R Nozaki, H Kondo, S P Awasthi, A Hinenoya, S Yamasaki, I Hirono
AIMS: To investigate the virulence of the Vp_PirAB-like genes in Vibrio parahaemolyticus- acute hepatopancreatic necrosis disease (AHPND)-causing strain and the factors that are associated with the virulence level. METHODS AND RESULTS: The virulence of Vp_PirAB-like was examined using a non-virulent strain FP11 of V. parahaemolyticus transformed with a plasmid harbouring Vp_PirAB-like genes and then it was used to challenge shrimp Litopenaeus vannamei and Marsupenaeus japonicus...
December 2016: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/27443384/pirb-overexpression-exacerbates-neuronal-apoptosis-by-inhibiting-trkb-and-mtor-phosphorylation-after-oxygen-and-glucose-deprivation-injury
#17
Zhao-Hua Zhao, Bin Deng, Hao Xu, Jun-Feng Zhang, Ya-Jing Mi, Xiang-Zhong Meng, Xing-Chun Gou, Li-Xian Xu
Previous studies have proven that paired immunoglobulin-like receptor B (PirB) plays a crucial suppressant role in neurite outgrowth and neuronal plasticity after central nervous system injury. However, the role of PirB in neuronal survival after cerebral ischemic injury and its mechanisms remains unclear. In the present study, the role of PirB is investigated in the survival and apoptosis of cerebral cortical neurons in cultured primary after oxygen and glucose deprivation (OGD)-induced injury. The results have shown that rebarbative PirB exacerbates early neuron apoptosis and survival...
May 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/27412551/-17%C3%AE-%C3%A2-estradiol-suppresses-hyperoxia%C3%A2-induced-apoptosis-of-oligodendrocyte-precursor-cells-through-paired%C3%A2-immunoglobulin%C3%A2-like-receptor-b
#18
Hua Wang, De-Zhi Mu
OBJECTIVE: To study the effect of hyperoxia and paired immunoglobin-like receptor B (PirB) on rat oligodendrocyte precursor cells (OPCs) in vivo and the neuroprotective effects of 17β-estradiol (E2) on these cells. METHODS: Rat OPCs were treated with different concentrations of E2 and the cells were harvested for RT‑qPCR analysis at different time points. PriB was silenced with small interfering siRNA. The effects of E2 treatment and silencing of PriB on OPCs viability and apoptosis under hyperoxic stimulation were detected using 3‑(4,5‑dimethylthi‑azol‑2‑yl)‑2,5‑diphenyltetrazolium bromide (MTT) assay and flow cytometry analysis...
July 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27324131/paired-ig-like-receptor-b-inhibits-il-13-driven-eosinophil-accumulation-and-activation-in-the-esophagus
#19
Netali Ben Baruch-Morgenstern, Melissa K Mingler, Emily Stucke, John A Besse, Ting Wen, Hadar Reichman, Ariel Munitz, Marc E Rothenberg
Eosinophilic esophagitis (EoE) is a Th2 cytokine-associated disease characterized by eosinophil infiltration, epithelial cell hyperplasia, and tissue remodeling. Recent studies highlighted a major contribution for IL-13 in EoE pathogenesis. Paired Ig-like receptor B is a cell surface immune-inhibitory receptor that is expressed by eosinophils and postulated to regulate eosinophil development and migration. We report that Pirb is upregulated in the esophagus after inducible overexpression of IL-13 (CC10-Il13(Tg) mice) and is overexpressed by esophageal eosinophils...
August 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/26821234/17%C3%AE-estradiol-suppresses-hyperoxia-induced-apoptosis-of-oligodendrocytes-through-paired-immunoglobulin-like-receptor-b
#20
Hua Wang, Jinlin Wu
Hyperoxia is a high risk factor for neurodevelopmental disorders and can cause nerve cell death. 17β‑Estradiol (E2) has been demonstrated as a neuroprotective agent. In the present study, the effect of hyperoxia on rat oligodendrocyte precursor cells (OPCs) in vivo and the neuroprotective effects of E2 on these cells were investigated. OPCs were treated with various concentrations of E2 and were harvested for reverse transcription‑quantitiative polymerase chain reaction (RT‑qPCR) analysis at various time‑points...
March 2016: Molecular Medicine Reports
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