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https://www.readbyqxmd.com/read/29334815/impact-of-medication-adherence-on-risk-of-ischemic-stroke-major-bleeding-and-deep-vein-thrombosis-in-atrial-fibrillation-patients-using-novel-oral-anticoagulants
#1
Chinmay G Deshpande, Stephen Kogut, Robert Laforge, Cynthia Willey
OBJECTIVES: Our study examined the impact of adherence to Novel Oral Anticoagulants (dabigatran and rivaroxaban) [NOACs] on ischemic-stroke (IS), major-bleeding (MB), deep-vein-thrombosis and pulmonary-embolism (DVTPE) risk in a large, nationwide, propensity-matched sample. METHODS: A retrospective cohort study utilized data from a US commercial insurance database (2010-2012). Adults patients with ≥1 diagnosis of atrial fibrillation/flutter (ICD-9 427.31/32), >1 prescription of NOACs and CHA2DS2-VASc score ≥1 were included...
January 16, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29327337/generalized-nonmotor-absence-seizures-what-do-absence-generalized-and-nonmotor-mean
#2
REVIEW
Iris Unterberger, Eugen Trinka, Peter W Kaplan, Gerald Walser, Gerhard Luef, Gerhard Bauer
OBJECTIVE: Clinical absences are now classified as "generalized nonmotor (absence) seizures" by the International League Against Epilepsy (ILAE). The aim of this paper is to critically review the concept of absences and to put the accompanying focal and motor symptoms into the context of the emerging pathophysiological knowledge. METHODS: For this narrative review we performed an extensive literature search on the term "absence," and analyzed the plethora of symptoms observed in clinical absences...
January 11, 2018: Epilepsia
https://www.readbyqxmd.com/read/29320668/the-impact-of-non-vitamin-k-antagonist-oral-anticoagulants-noacs-on-anticoagulation-therapy-in-rural-australia
#3
Jamie W Bellinge, Jarrad J Paul, Liam S Walsh, Lokesh Garg, Gerald F Watts, Carl Schultz
OBJECTIVE: To determine the use of different anticoagulation therapies in rural Western Australia; to establish whether remoteness from health care services affects the choice of anticoagulation therapy; to gather preliminary data on anticoagulation therapy safety and efficacy. DESIGN: Retrospective cohort study of patients hospitalised with a principal diagnosis of atrial fibrillation/flutter (AF) or venous thromboembolism (VTE) during 2014-2015. SETTING: Four hospitals serving two-thirds of the rural population of Western Australia...
January 15, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29318626/trends-and-predictors-of-implantable-cardioverter-defibrillator-implantation-after-sudden-cardiac-arrest-insight-from-the-national-inpatient-sample
#4
Muhammad Bilal Munir, Fahad Alqahtani, Sami Aljohani, Ashwin Bhirud, Sujal Modi, Mohamad Alkhouli
BACKGROUND: Implantable cardioverter defibrillator (ICD) has a class IA indication in survivors of sudden cardiac arrest (SCA) provided no reversible cause is identified. We sought to determine trends and predictors of ICD implant in SCA patients from a national sample of United States population. METHODS AND RESULTS: Data was gathered from National Inpatient Sample (NIS) from January 2003 to December 2014. All patients ≥ 18 years of age with a primary discharge diagnosis of SCA, ventricular fibrillation (VF), ventricular flutter, and ventricular tachycardia (VT) were included...
January 9, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29317316/thirty-day-readmissions-after-cardiac-implantable-electronic-devices-in-the-united-states-insights-from-the-nationwide-readmissions-database
#5
Brijesh Patel, Naveen Sablani, Jalaj Garg, Rahul Chaudhary, Mahek Shah, Rahul Gupta, Talha Nazir, Babak Bozorgnia, Santosh K Padala, Sampath Gunda, Kenneth A Ellenbogen
BACKGROUND: Limited data are available regarding true estimates of individual complications contributing to readmissions after cardiac implantable electronic device (CIED) implantation. OBJECTIVE: We aimed to identify predictors of 30-day readmission in patients admitted for CIED implantation. METHODS: The study cohort consisted of patients who received CIED implantation in 2014, identified from National Readmission Database. Readmission was defined as a subsequent hospital admission within 30 days after discharge day of index admission...
January 6, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29316355/finite-element-models-of-flagella-with-sliding-radial-spokes-and-inter-doublet-links-exhibit-propagating-waves-under-steady-dynein-loading
#6
Tianchen Hu, Philip V Bayly
It remains unclear how flagella generate propulsive, oscillatory waveforms. While it is well known that dynein motors, in combination with passive cytoskeletal elements, drive the bending of the axoneme by applying shearing forces and bending moments to microtubule doublets, the origin of rhythmicity is still mysterious. Most conceptual models of flagellar oscillation involve dynein regulation or switching, so that dynein activity first on one side of the axoneme, then the other, drives bending. In contrast, a "viscoelastic flutter" mechanism has recently been proposed, based on a dynamic structural instability...
January 5, 2018: Cytoskeleton
https://www.readbyqxmd.com/read/29310916/chimeric-antigen-receptor-engineered-human-gamma-delta-t-cells-enhanced-cytotoxicity-with-retention-of-cross-presentation
#7
Anna Capsomidis, Gabriel Benthall, Heleen H Van Acker, Jonathan Fisher, Anne M Kramer, Zarah Abeln, Yvonne Majani, Talia Gileadi, Rebecca Wallace, Kenth Gustafsson, Barry Flutter, John Anderson
Gamma delta T (γδT) lymphocytes are primed for rapid function, including cytotoxicity toward cancer cells, and are a component of the immediate stress response. Following activation, they can function as professional antigen-presenting cells. Chimeric antigen receptors (CARs) work by focusing T cell function on defined cell surface tumor antigens and provide essential costimulation for robust activation. Given the natural tropism of γδT cells for the tumor microenvironment, we hypothesized that their transduction with CARs might enhance cytotoxicity while retaining their ability to migrate to tumor and act as antigen-presenting cells to prolong the intratumoral immune response...
December 8, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29306591/the-frequency-and-risk-factors-for-ischemic-stroke-in-myotonic-dystrophy-type-1-patients
#8
Kosuke Yoshida, Yoko Aburakawa, Yasuhiro Suzuki, Kenji Kuroda, Takashi Kimura
INTRODUCTION: Patients with myotonic dystrophy type 1 have several cardiac abnormalities, especially myocardial conduction disorders. Few studies have investigated cerebral infarction. We investigated the frequency of both symptomatic and asymptomatic ischemic strokes in patients with myotonic dystrophy type 1. METHODS: Patients who were diagnosed with myotonic dystrophy type 1 using genetic testing or clinical examinations at Asahikawa Medical Center were included...
January 3, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29306315/-atrial-flutter-probably-related-to-pazopanib-a-case-report
#9
Ana Puebla Villaescusa, Estrella Díaz Gómez, Ángel Luis Salcedo Mingoarranz, Sebastián Ramírez Cruz, Francisco José Hidalgo Correas, Benito García Díaz
No abstract text is available yet for this article.
January 1, 2018: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/29304952/clinical-effectiveness-of-a-systematic-pill-in-the-pocket-approach-for-the-management-of-paroxysmal-atrial-fibrillation
#10
Jason G Andrade, Jenny MacGillivray, Laurent Macle, Ren Jie Robert Yao, Matthew Bennett, Christopher B Fordyce, Nathaniel Hawkins, Andrew Krahn, John Jue, Krishnan Ramanathan, Teresa Tsang, Ken Gin, Marc W Deyell
BACKGROUND: For patients with symptomatic, sustained atrial fibrillation (AF), a "pill-in-the-pocket" antiarrhythmic drug (PIP-AAD) strategy has been proposed to reduce emergency department (ED) use. OBJECTIVE: To assess the clinical utility of a protocolled PIP-AAD approach within contemporary practice. METHODS: Consecutive patients who hemodynamically tolerated symptomatic, sustained AF were prospectively managed with the PIP-AAD strategy...
January 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29282836/geometric-patterns-of-time-delay-plots-from-different-cardiac-rhythms-and-arrhythmias-using-short-term-ekg-signals
#11
Raúl A Borracci, José D Montoya Pulvet, Carlos A Ingino, Mario Fitz Maurice, Alfredo Hirschon Prado, Enrique Dominé
OBJECTIVE: To date, no systematic work has been intended to describe spatio-temporal patterns of cardiac rhythms using only short series of RR intervals, to facilitate visual or computerized-aided identification of EKG motifs for use in clinical practice. The aim of this study was to detect and classify eye-catching geometric patterns of Poincaré time-delay plots from different types of cardiac rhythms and arrhythmias using short-term EKG signals. METHODS: Approximately 150-300 representative, consecutive beats were retrieved from 24-h Holter registers of 100 patients with different heart rhythms...
December 27, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/29250277/evaluating-the-utility-of-mhealth-ecg-heart-monitoring-for-the-detection-and-management-of-atrial-fibrillation-in-clinical-practice
#12
Kathleen T Hickey, Angelo B Biviano, Hasan Garan, Robert R Sciacca, Teresa Riga, Kate Warren, Ashton P Frulla, Nicole R Hauser, Daniel Y Wang, William Whang
Background: Little attention has focused on the integration of mobile health (mHealth) technology with self-management approaches to improve the detection and management of atrial fibrillation (AF) in clinical practice. Objective: The objective of this study was to investigate the differences between mHealth and usual care over a 6-month follow-up period among patients with a known history of atrial fibrillation. Methods: A pilot cohort from within the larger ongoing randomized trial, iPhone® Helping Evaluate Atrial fibrillation Rhythm through Technology (iHEART), was evaluated to determine differences in detection of AF and atrial flutter (AFL) recurrence rates (following treatment to restore normal rhythm) between patients undergoing daily smartphone ECG monitoring and age and gender matched control patients...
February 2017: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/29250234/postpacing-interval-during-right-ventricular-overdrive-pacing-to-discriminate-supraventricular-from-ventricular-tachycardia
#13
Kivanc Yalin, Ebru Golcuk, Ekrem Bilal Karaayvaz, Tolga Aksu, Muhammet Arslane, Selma Kenar Tiryakioglu, Ahmet Kaya Bilge, Kamil Adalet
Introduction: Failure to differentiate supraventricular from ventricular arrhythmias is the most frequent cause of inappropriate implantable cardioverter-defibrillator (ICD) therapies. We hypothesized that the postpacing interval (PPI) after overdrive right ventricular pacing may differentiate ventricular (VT) from supraventricular tachycardia (SVT) such as sinus tachycardia, atrial flutter and atrial tachycardia. This hypothesis is based on the entrainment maneuver. Reentrant tachycardia circuit for VTs would haveshorter distance to RV apex than SVTs have, and the conduction time between a ventricular pacing site and the tachycardia origin is expected to be shorter in VTs than in SVTs...
August 2017: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/29250227/routine-use-of-intracardiac-echocardiography-for-atrial-flutter-ablation-is-associated-with-reduced-fluoroscopy-time-but-not-with-a-reduction-of-radiofrequency-energy-delivery-time
#14
Dalibor Herman, Pavel Osmancik, Jana Zdarska, Radka Prochazkova
Background: The ablation of cavotricuspid-isthmus (CTI) atrial flutter (AFL) dependent atrial flutter could be difficult in patients with complex anatomy of the CTI.The aim of the study was to assess whether the use of intracardiac echocardiography (ICE) was associated with less fluoroscopy time and faster ablations of cavotricuspid isthmus dependent atrial flutter (CTI-AFL). Methods: Patients with an indication for an ablation of a CTI-AFL were enrolled. Patients in which ablation of a CTI-AFLas part of an atrial fibrillation ablation were not included...
August 2017: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/29250225/atrial-fibrillation-in-patients-with-congenital-heart-disease
#15
REVIEW
Tabitha G Moe, Victor A Abrich, Edward K Rhee
Advances in surgical techniques have led to the survival of most patients with congenital heart disease (CHD) up to their adulthood. During their lifetime, many of them develop atrial tachyarrhythmias due to atrial dilatation and scarring from surgical procedures. More complex defects and palliative repairs are linked to a higher incidence and earlier occurrence of arrhythmias. Atrial fibrillation (AF) is common in patients who have atrial septal defects repaired after age 55 and in patients with tetralogy of Fallot repaired after age 45...
June 2017: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/29246961/first-line-antiarrhythmic-transplacental-treatment-for-fetal-tachyarrhythmia-a-systematic-review-and-meta-analysis
#16
REVIEW
Tarek Alsaied, Shankar Baskar, Munes Fares, Fares Alahdab, Richard J Czosek, Mohammad Hassan Murad, Larry J Prokop, Allison A Divanovic
BACKGROUND: There is no consensus on the most effective and best tolerated first-line antiarrhythmic treatment for fetal tachyarrhythmia. The purpose of this systematic review and meta-analysis was to compare the efficacy, safety, and fetal-maternal tolerance of first-line monotherapies for fetal supraventricular tachycardia and atrial flutter. METHODS AND RESULTS: A comprehensive search of several databases was conducted through January 2017. Only studies that made a direct comparison between first-line treatments of fetal tachyarrhythmia were included...
December 15, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29244075/the-athlete-s-heart-is-a-proarrhythmic-heart-and-what-that-means-for-clinical-decision-making
#17
Hein Heidbuchel
Recurring questions when dealing with arrhythmias in athletes are about the cause of the arrhythmia and, more importantly, about the eligibility of the athlete to continue sports activities. In essence, the relation between sports and arrhythmias can be understood along three lines: sports as arrhythmia trigger on top of an underlying problem, sports as arrhythmic substrate promotor, or sports as substrate inducer. Often, there is no sharp divider line between these entities. The athlete's heart, a heart that adapts so magically to cope with the demands of exercise, harbours many structural and functional changes that by themselves predispose to arrhythmia development, at the atrial, nodal and ventricular levels...
December 13, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29237033/colchicine-for-prevention-of-perioperative-atrial-fibrillation-in-patients-undergoing-lung-resection-surgery-a-pilot-randomized-controlled-study
#18
Amal Bessissow, John Agzarian, Yaron Shargall, Sadeesh Srinathan, John Neary, Vikas Tandon, Christian Finley, Jeff S Healey, David Conen, Reitze Rodseth, Shirley Pettit, William Dechert, Otto Regalado, Chinthanie Ramasundarahettige, Saleh Alshalash, P J Devereaux
OBJECTIVES: We carried out a pilot randomized controlled study to determine the feasibility of a large trial evaluating the impact of colchicine versus placebo on postoperative atrial fibrillation or atrial flutter (POAF) among patients undergoing lung resection surgery. METHODS: Patients ≥55 years of age undergoing lung resection surgery were randomly assigned to receive colchicine 0.6 mg or placebo starting a few hours before surgery. Postoperatively, patients received colchicine 0...
December 9, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29229471/patent-foramen-ovale-closure-for-secondary-prevention-of-cryptogenic-stroke-updated-meta-analysis-of-randomized-clinical-trials
#19
Muthiah Vaduganathan, Arman Qamar, Ankur Gupta, Navkaranbir Bajaj, Harsh B Golwala, Ambarish Pandey, Deepak L Bhatt
BACKGROUND: Patent foramen ovale closure represents a potential secondary prevention strategy for cryptogenic stroke, but available trials have varied by size, device studied, and follow-up. METHODS: We conducted a systematic search of published randomized clinical trials (RCTs) evaluating patent foramen ovale closure vs. medical therapy in patients with recent stroke or transient ischemic attack using PubMED, EMBASE, and Cochrane through September 2017. Weighting was by random effects models...
December 8, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29223947/-trigeminy-of-ventricular-bigeminy-caused-by-reentrant-mechanism-reentry-of-reentry
#20
Oscar A Pellizzón, Marcelo V Elizari
The process that follows an acute myocardial infarction generates an appropriate substrate for the formation of reentry circuits, considered to be the most frequent mechanism of ventricular extrasystoles and tachyarrhythmias. We present the case of a patient with an acute myocardial infarction unusually concurring with ventricular trigeminy coupled to ventricular bigeminated extrasystoles giving rise to a trigeminy sequence over the bigeminy, which indicates the existence of two reentry circuits (reentry of reentry) that trigger ventricular flutter...
2017: Medicina
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