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Pelvis discontinuity

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https://www.readbyqxmd.com/read/29181213/therapeutic-management-of-a-substantial-pelvic-aneurysmatic-bone-cyst-including-the-off-label-use-of-denosumab-in-a-35-year-old-female-patient
#1
D Ntalos, M Priemel, C Schlickewei, D M Thiesen, J M Rueger, A S Spiro
Aneurysmal bone cysts (ABC) are benign bone tumors, which are highly vascularized. The main course of treatment is curettage followed by bone grafting or cement insertion. Still recurrence remains a main problem for patients. Denosumab is a monoclonal antibody, which acts as an inhibitor of the RANK/RANKL pathway, diminishing bone turnover. Recent case reports have shown that Denosumab can be a promising therapeutic agent for people suffering from therapy-resistant ABC. We report the case of a 35-year-old female patient presenting with a pronounced ABC of the pelvis...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29083977/examining-the-effect-of-medication-adherence-on-risk-of-subsequent-fracture-among-women-with-a-fragility-fracture-in-the-u-s-medicare-population
#2
Allison Keshishian, Natalie Boytsov, Russel Burge, Kelly Krohn, Louise Lombard, Xiang Zhang, Lin Xie, Onur Baser
BACKGROUND: In the United States, osteoporosis affects approximately 10 million people, of whom 80% are women, and it contributes a significant clinical burden to the community. Poor adherence to osteoporosis medications adds to the overall burden of illness. OBJECTIVE: To examine the association of osteoporosis medication adherence and the risk of a subsequent fracture among Medicare-enrolled women with a previous fragility fracture. METHODS: This study was a retrospective observational analysis of U...
November 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29043140/warfarin-related-nephropathy-in-a-patient-with-renal-pelvic-cancer
#3
Yuki Nagasako, Akiko Fujii, Satoshi Furuse, Katsunori Saito, Naobumi Mise
An 83-year-old Japanese man had a history of chronic heart failure due to bradycardia-tachycardia syndrome. He was admitted to our hospital because of macrohematuria and acute kidney injury (AKI), which were detected by an urologist at an outpatient visit. He had a history of recurrent macrohematuria and transurethral resection of bladder tumors twice in the preceding 2 years. He had been on warfarin for 12 years, with a stable international normalized ratio (INR) that was usually less than 2.1. Urinalysis revealed numerous red blood cells (RBCs) and mild proteinuria without RBC casts...
2017: Clinical Nephrology. Case Studies
https://www.readbyqxmd.com/read/28878601/an-atypical-presentation-of-retroperitoneal-fibrosis
#4
Wei Phin Tan, Thomas Hwang, Robert Medairos, Dennis A Pessis
A 69-year-old man with a psoriatic arthritis treated with infliximab for 1 month presented to the urology clinic for lower urinary tract symptoms. He was found to have a new diagnosis of elevated creatinine. Computed tomography of the abdomen and pelvis revealed bilateral severe hydronephrosis with abnormal soft tissue thickening of the right renal pelvis and proximal ureter. Bilateral stents were placed after ureteroscopy demonstrated no abnormalities. A computed tomography-guided biopsy of the peri-ureteral lesions revealed fibroadipose tissue with sclerosis and extensive chronic inflammation consistent with retroperitoneal fibrosis...
August 2017: Current Urology
https://www.readbyqxmd.com/read/28846822/extended-pharmacologic-thromboprophylaxis-in-oncologic-liver-surgery-is-safe-and-effective
#5
B J Kim, R W Day, C H Davis, N Narula, M H Kroll, C W D Tzeng, T A Aloia
Essentials The risk for venous thromboembolism after liver surgery remains high in the modern era. We evaluated the safety/efficacy of extended anticoagulation in liver surgery. This protocol reports zero venous thromboembolism events in 124 liver surgery patients. Extended anticoagulation after oncologic liver surgery is safe and effective. SUMMARY: Background The incidence of venous thromboembolism (VTE) after liver surgery remains high. Objective To evaluate the safety and efficacy of extended pharmacologic thromboprophylaxis after liver surgery for the prevention of VTE...
November 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28357106/persistent-arthralgia-vomiting-and-hypercalcemia-as-the-initial-manifestations-of-hyperthyroidism-a-case-report
#6
Jingfang Liu, Xulei Tang, Jianguo Cheng, Xiaomei Yang, Yan Wang
A 53-year-old woman presented with persistent edema and pain of the metacarpophalangeal and proximal interphalangeal joints and the wrist, knee and ankle joints, with more recent intermittent nausea and vomiting. Treatment for rheumatoid arthritis and osteoarthritis was ineffective. No clinical manifestations typical of hyperthyroidism were observed. The results of the thyroid function tests were as follows: Thyroid-stimulating hormone, 0.003 µIU/ml; triiodothyronine (T3), 4.44 ng/ml;, thyroxine (T4) >30 µg/dl; free T3, 14...
February 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28350548/pelvic-discontinuity-associated-with-total-hip-arthroplasty-evaluation-and-management
#7
Matthew P Abdel, Robert T Trousdale, Daniel J Berry
Pelvic discontinuity is a challenging complication encountered during revision total hip arthroplasty. Pelvic discontinuity is defined as a separation of the ilium superiorly from the ischiopubic segment inferiorly and is typically a chronic condition in failed total hip arthroplasties in the setting of bone loss. After a history and a physical examination have been completed and infection has been ruled out, appropriate imaging must be obtained, including plain hip radiographs, oblique Judet radiographs, and often a CT scan...
May 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28335748/steroid-resistant-nephrotic-syndrome-as-the-initial-presentation-of-nail-patella-syndrome-a-case-of-a-de-novo-lmx1b-mutation
#8
Tomohiro Nakata, Ryo Ishida, Yuu Mihara, Atsuko Fujii, Yoshimoto Inoue, Tetsuro Kusaba, Tsuyoshi Isojima, Yutaka Harita, Chiaki Kanda, Sachiko Kitanaka, Keiichi Tamagaki
BACKGROUND: Nail-patella syndrome (NPS) is an autosomal dominant disorder caused by mutations in the LMX1B gene and is characterized by nail dysplasia, skeletal abnormalities, and nephropathy. We herein report a case of steroid-resistant nephrotic syndrome (SRNS) prior to overt orthopedic symptoms in a patient with NPS. CASE PRESENTATION: A 24-year-old woman presented to our hospital with knee pain. She had poorly developed nails, hypoplastic patellas, dislocation of the elbows, and iliac horns in the pelvis...
March 23, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28326425/bilateral-pelvic-discontinuity-a-unique-condition-characterized-by%C3%A2-high-failure-rates-of-current-treatment
#9
John R Martin, Ian Barrett, Rafael J Sierra, David G Lewallen, Daniel J Berry
BACKGROUND: Bilateral pelvic discontinuity is characterized by complete dissociation of the superior and inferior pelvis secondary to bone loss or fracture. The end result is a freely mobile inferior pelvis at the level of each discontinuity which presents a significant reconstruction challenge. This clinical entity has not been described previously, and the results of surgical treatment are not known. METHODS: We retrospectively reviewed all identified cases of pelvic discontinuity (PD) treated with revision THA at one institution...
December 2016: Arthroplasty Today
https://www.readbyqxmd.com/read/28297189/pelvic-inlet-shape-is-not-as-dimorphic-as-previously-suggested
#10
Hillary Delprete
It is well known that there are significant differences in the pelves of males and females due, in part, to differing constraints. The male and female pelves must be suitable for upright posture and locomotion, but the female pelvis must also be suitable for reproduction. These differing requirements lead to differences in the shape and size of various pelvic dimensions. These differences are reflected in the pelvic inlet, midplane, and outlet. Current research has documented dimorphisms in the posterior and anterior spaces in all three of these planes...
April 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28263283/running-technique-is-an-important-component-of-running-economy-and-performance
#11
Jonathan P Folland, Sam J Allen, Matthew I Black, Joseph C Handsaker, Stephanie E Forrester
Despite an intuitive relationship between technique and both running economy (RE) and performance, and the diverse techniques used by runners to achieve forward locomotion, the objective importance of overall technique and the key components therein remain to be elucidated. PURPOSE: This study aimed to determine the relationship between individual and combined kinematic measures of technique with both RE and performance. METHODS: Ninety-seven endurance runners (47 females) of diverse competitive standards performed a discontinuous protocol of incremental treadmill running (4-min stages, 1-km·h increments)...
July 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27780167/do-jj-stents-increase-the-effectiveness-of-extracorporeal-shock-wave-lithotripsy-for-pediatric-renal-stones
#12
Metin Gündüz, Tamer Sekmenli, İlhan Ciftci, Ahmet Midhat Elmacı
PURPOSE: We aimed to evaluate the effects of preoperative urinary catheterization in nephrolithiasis treatment with extracorporeal shock wave lithotripsy (SWL). METHODS: Patients admitted to the Department of Pediatric Surgery for renal stones between June 2012 and June 2014 were evaluated retrospectively. Patients were divided into 2 groups based on JJ stent placements. Group 1 did not receive JJ stents, while group 2 did. The recorded demographic data for each group included age, gender, stone size, location, sessions, and complications...
2017: Urologia Internationalis
https://www.readbyqxmd.com/read/27737963/long-term-single-institute-experience-with-trimodal-bladder-preserving-therapy-with-proton-beam-therapy-for-muscle-invasive-bladder-cancer
#13
Ei-Ichiro Takaoka, Jun Miyazaki, Hitoshi Ishikawa, Koji Kawai, Tomokazu Kimura, Ryutaro Ishitsuka, Takahiro Kojima, Reiko Kanuma, Daichi Takizawa, Toshiyuki Okumura, Hideyuki Sakurai, Hiroyuki Nishiyama
OBJECTIVE: We retrospectively elucidated the oncological outcomes, prognostic factors and toxicities of proton beam therapy in trimodal bladder-preserving therapy for muscle-invasive bladder cancer at our institution. METHODS: From 1990 to 2015, 70 patients with cT2-3N0M0 muscle-invasive bladder cancer underwent trimodal bladder-preserving therapy consisting of maximal transurethral resection of the bladder tumor, small pelvis photon irradiation, intra-arterial chemotherapy and proton beam therapy...
January 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27733243/nivolumab-monotherapy-in-recurrent-metastatic-urothelial-carcinoma-checkmate-032-a-multicentre-open-label-two-stage-multi-arm-phase-1-2-trial
#14
MULTICENTER STUDY
Padmanee Sharma, Margaret K Callahan, Petri Bono, Joseph Kim, Pavlina Spiliopoulou, Emiliano Calvo, Rathi N Pillai, Patrick A Ott, Filippo de Braud, Michael Morse, Dung T Le, Dirk Jaeger, Emily Chan, Chris Harbison, Chen-Sheng Lin, Marina Tschaika, Alex Azrilevich, Jonathan E Rosenberg
BACKGROUND: Few effective treatments exist for patients with advanced urothelial carcinoma that has progressed after platinum-based chemotherapy. We assessed the activity and safety of nivolumab in patients with locally advanced or metastatic urothelial carcinoma whose disease progressed after previous platinum-based chemotherapy. METHODS: In this phase 1/2, multicentre, open-label study, we enrolled patients (age ≥18 years) with urothelial carcinoma of the renal pelvis, ureter, bladder, or urethra at 16 sites in Finland, Germany, Spain, the UK, and the USA...
November 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27648348/hypercalcemia-of-malignancy
#15
REVIEW
Steve Malangone, Christopher J Campen
A 60-year-old man initially presented with pain in the right upper quadrant in October 2010. A computed tomography (CT) scan of the abdomen pelvis completed at that time showed a mass at the junction of the body and tail of the pancreas and multiple large liver lesions. A CT-guided liver biopsy revealed low-grade neuroendocrine carcinoma. The patient was initially started on systemic treatment with sunitinib (Sutent) and octreotide. He developed intolerable side effects, including nausea and migraine. Therapy was discontinued in October 2011, when a CT scan revealed evidence of disease progression...
November 2015: Journal of the Advanced Practitioner in Oncology
https://www.readbyqxmd.com/read/27471210/preoperative-evaluation-for-pelvic-discontinuity-using-a-new-reformatted-computed-tomography-scan-protocol
#16
Keith A Fehring, Benjamin M Howe, John R Martin, Michael J Taunton, Daniel J Berry
BACKGROUND: The identification of suspected pelvic discontinuity is important for preoperative planning in revision hip arthroplasty. Computed tomography (CT) of the pelvis with reconstructions in the axial, sagittal, and coronal planes has been previously described for the identification of pelvic discontinuity but fails to show some discontinuities. The purpose of this study was to determine whether reformatted 45° oblique CT scans of the pelvis, similar in projection to Judet views on plain films, provide advantages in detecting pelvic discontinuity preoperatively over standard reconstruction CT scans...
October 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27411856/anti-estrogen-withdrawal-effect-with-raloxifene-a-case-report
#17
Walter Lemmo
A 66-year-old patient presented with acute recurrent metastatic estrogen and progesterone receptor-positive, Her-2/neu-negative breast cancer, bone lesions (lumbar spine, pelvis), pulmonary nodules, hepatic metastasis, elevated cancer antigen 15 and liver enzymes, dyspepsia, and diarrhea. The patient had been taking raloxifene for approximately 8 years. After discontinuation, clinical parameters and symptoms improved rapidly without oncological therapy or other forms of treatment. Three months after raloxifene discontinuation, capecitabine was initiated by the treating oncologist who deemed an anti-estrogen withdrawal effect (AEWE) implausible...
September 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27246722/high-resolution-t2-weighted-cervical-cancer-imaging-a-feasibility-study-on-ultra-high-field-7-0-t-mri-with-an-endorectal-monopole-antenna
#18
Jacob P Hoogendam, Irene M L Kalleveen, Catalina S Arteaga de Castro, Alexander J E Raaijmakers, René H M Verheijen, Maurice A A J van den Bosch, Dennis W J Klomp, Ronald P Zweemer, Wouter B Veldhuis
OBJECTIVES: We studied the feasibility of high-resolution T2-weighted cervical cancer imaging on an ultra-high-field 7.0-T magnetic resonance imaging (MRI) system using an endorectal antenna of 4.7-mm thickness. METHODS: A feasibility study on 20 stage IB1-IIB cervical cancer patients was conducted. All underwent pre-treatment 1.5-T MRI. At 7.0-T MRI, an external transmit/receive array with seven dipole antennae and a single endorectal monopole receive antenna were used...
March 2017: European Radiology
https://www.readbyqxmd.com/read/27077468/a-case-of-suggested-ibuprofen-induced-acute-pancreatitis
#19
Maitham A Moslim, Thomas C Sodeman, Ali T Nawras
Drug-induced acute pancreatitis (DIP) is uncommon and may account for 2%-5% of cases, although the incidence may be increasing nowadays. DIP has been documented for more than 160 drugs in the literature. The most common nonsteroidal anti-inflammatory drugs (NSAIDs) that have been reported to cause pancreatitis are sulindac and salicylates. In this report, we present a case of probable ibuprofen-induced pancreatitis. A 60-year-old white woman presented with the sudden onset of mild acute pancreatitis (AP) 5 hours following the ingestion of 6 tablets of ibuprofen (Advil) 200 mg (equivalent to 20...
November 2016: American Journal of Therapeutics
https://www.readbyqxmd.com/read/26805294/-a-case-of-abdominal-wall-hernia-rupture-during-bevacizumab-treatment
#20
Satoshi Sugimoto, Yasuaki Miyazaki, Sou Hirose, Toshiya Michiura, Shigeo Fujita, Kazuo Yamabe, Satoru Miyazaki, Makio Nagaoka
A 78 -year-old man with rectal cancer underwent abdominoperineal resection of the rectum. In the postoperative period, the patient experienced wound infection, leading to an abdominal wall hernia. Two years following surgery, a rise in the serum CEA level was seen. A metastatic tumor was detected in the right lung on chest CT. VATS right lung inferior lobe segmental resection was performed. After lobectomy, the serum CEA level continued to increase. Another metastatic tumor was detected in the right lung on chest CT...
November 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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