Sara Monticelli, Alina Sommer, Zeinab AlHajj Hassan, Clarisabel Garcia Rodriguez, Kémy Adé, Pierre Cattenoz, Claude Delaporte, Elisa Gomez Perdiguero, Angela Giangrande
Macrophages constitute the first defense line against the non-self, but their ability to remodel their environment in organ development/homeostasis is starting to be appreciated. Early-wave macrophages (EMs), produced from hematopoietic stem cell (HSC)-independent progenitors, seed the mammalian fetal liver niche wherein HSCs expand and differentiate. The involvement of niche defects in myeloid malignancies led us to identify the cues controlling HSCs. In Drosophila, HSC-independent EMs also colonize the larva when late hematopoiesis occurs...
April 1, 2024: Developmental Cell