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https://www.readbyqxmd.com/read/28096427/influence-of-fatiguing-noise-on-auditory-evoked-responses-to-stimuli-of-various-levels-in-a-beluga-whale-delphinapterus-leucas
#1
Vladimir V Popov, Evgeniya V Sysueva, Dmitry I Nechaev, Viatcheslav V Rozhnov, Alexander Ya Supin
The negative impact of man-made noise on the hearing of odontocetes attracts considerable recent attention. Mostly permanent or temporary reductions in sensitivity are known as permanent or temporary threshold shift (PTS or TTS, respectively) were investigated. In the present study, the effects of a fatiguing sound on the hearing of a beluga whale Delphinapterus leucas within a wide range of levels of test signals was investigated. The fatiguing noise was half-octave band-limited noise centered at 32 kHz. Post-exposure effects of this noise on the evoked responses to test stimuli (rhythmic pip trains with a 45-kHz center frequency) at various levels (from threshold to 60 dB above threshold) was measured...
January 17, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28087550/trends-and-changes-in-paediatric-tonsil-surgery-in-sweden-1987-2013-a-population-based-cohort-study
#2
Anna Borgström, Pia Nerfeldt, Danielle Friberg, Ola Sunnergren, Joacim Stalfors
OBJECTIVES: The objective of this study was to longitudinally describe the history of tonsil surgery in Swedish children and adolescents regarding incidence, indications for surgery, surgical methods and the age and gender distributions. SETTING: A retrospective longitudinal population-based cohort study based on register data from the Swedish National Patient Register (NPR) and population data from Statistics Sweden. PARTICIPANTS: All Swedish children 1-<18 years registered in the NPR with a tonsil surgery procedure 1987-2013...
January 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28078406/-temporary-hearing-threshold-shift-tts-caused-by-impulse-noise
#3
O Michel
No abstract text is available yet for this article.
January 11, 2017: HNO
https://www.readbyqxmd.com/read/28071990/natural-course-of-euthyroidism-and-clues-for-early-diagnosis-of-thyroid-dysfunctions-tehran-thyroid-study-tts
#4
Atieh Amouzegar, Zahra Ghaemmaghami, Maani Beygi, Safoora Gharibzadeh, Ladan Mehran, Maryam Tohidi, Fereidoun Azizi
OBJECTIVE: Considering the limited data available on the natural course of euthyroidism, this study was designed to evaluate the progression in time from euthyroidism to subclinical or overt hypo - or hyperthyroidism. METHODS: This study was conducted within the framework of the Tehran Thyroid cohort study (TTS), in which 5783 individuals aged 40.4 ± 0.2 years were followed for 6 years. The overall loss to follow-up rate was 8.3%. After applying exclusion criteria, data of 4204 euthyroid subjects remained for analysis of a six-year natural course analysis...
January 10, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28052092/the-prevalence-incidence-and-natural-course-of-positive-antithyroperoxidase-antibodies-in-a-population-based-study-tehran-thyroid-study
#5
Atieh Amouzegar, Safoora Gharibzadeh, Elham Kazemian, Ladan Mehran, Maryam Tohidi, Fereidoun Azizi
OBJECTIVE: Thyroid peroxidase antibody (TPOAb), the most common antibody frequently measured in population surveys is a protein expressed in the thyroid gland. We conducted the present study to analyze the prevalence and incidence of thyroid auto immunity and natural course of TPOAb in a population based study. MATERIAL AND METHODS: This prospective study was conducted within the framework of the Tehran Thyroid Study (TTS) on 5783 (2376 men and 3407 women) individuals aged ≥ 20 years who had thyroid function tests at baseline and were followed up for median 9...
2017: PloS One
https://www.readbyqxmd.com/read/28039647/a-multicenter-experience-of-through-the-scope-balloon-assisted-enteroscopy-in-surgically-altered-gastrointestinal-anatomy
#6
Jennifer X Cai, David L Diehl, Ralf Kiesslich, Andrew C Storm, Mohamad H El Zein, Alan H Tieu, Arthur Hoffman, Vikesh K Singh, Mouen A Khashab, Patrick I Okolo, Vivek Kumbhari
BACKGROUND: Surgically altered gastrointestinal anatomy poses challenges for deep enteroscopy. Current overtube-assisted methods have long procedure times and utilize endoscopes with smaller working channels that preclude use of standard accessories. A through-the-scope balloon-assisted enteroscopy (TTS-BAE) device uses standard endoscopes with a large working channel to allow metallic and plastic stent insertion. We aim to determine the efficacy and safety of TTS-BAE in patients with altered surgical anatomy...
December 30, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/28011809/safety-and-efficacy-of-tocotrienol-supplementation-for-bone-health-in-postmenopausal-women-protocol-for-a-dose-response-double-blinded-placebo-controlled-randomised-trial
#7
Chwan-Li Shen, Huanbiao Mo, Shengping Yang, Shu Wang, Carol K Felton, Michael D Tomison, Ima Nirwana Soelaiman
INTRODUCTION: Osteoporosis is a major health concern in postmenopausal women, and oxidative stress contributes to the development of bone loss. Cellular studies and ovariectomised rat model mimicking bone loss in postmenopausal women show the bone-protective effect of tocotrienols (TTs) with antioxidant capability. We aim to access the safety and efficacy of TT consumption for bone health in postmenopausal women. METHODS AND ANALYSIS: In this 12-week randomised double-blinded placebo-controlled trial for the effects of dietary TT supplementation in postmenopausal women, postmenopausal women aged 45 years and older with at least 1 year after menopause and bone mineral density T-score at the spine and/or hip 2...
December 23, 2016: BMJ Open
https://www.readbyqxmd.com/read/28007746/optical-coherence-tomography-to-evaluate-plaque-burden-and-morphology-in-patients-with-takotsubo-syndrome
#8
Ingo Eitel, Thomas Stiermaier, Tobias Graf, Christian Möller, Karl-Philipp Rommel, Charlotte Eitel, Gerhard Schuler, Holger Thiele, Steffen Desch
BACKGROUND: Disrupted atherosclerotic plaques in the left anterior descending coronary artery are discussed controversially as a potential pathophysiological mechanism in Takotsubo syndrome (TTS). Therefore, the aim of the present study was to assess plaque burden and morphology by using optical coherence tomography in patients with TTS. METHODS AND RESULTS: A total of 23 consecutive TTS patients were included in this single-center study and underwent optical coherence tomography imaging of the left main coronary artery and the left anterior descending coronary artery at acute presentation...
December 22, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28003148/evidence-of-hidden-hearing-loss-following-noise-exposures-that-produce-robust-tts-and-abr-wave-i-amplitude-reductions
#9
Edward Lobarinas, Christopher Spankovich, Colleen G Le Prell
In animals, noise exposures that produce robust temporary threshold shifts (TTS) can produce immediate damage to afferent synapses and long-term degeneration of low spontaneous rate auditory nerve fibers. This synaptopathic damage has been shown to correlate with reduced auditory brainstem response (ABR) wave-I amplitudes at suprathreshold levels. The perceptual consequences of this "synaptopathy" remain unknown but have been suggested to include compromised hearing performance in competing background noise...
December 19, 2016: Hearing Research
https://www.readbyqxmd.com/read/27998902/dural-ossification-associated-with-ossification-of-ligamentum-flavum-in-the-thoracic-spine-a-retrospective-analysis
#10
Bo Li, Guixing Qiu, Shigong Guo, Wenjing Li, Ye Li, Huiming Peng, Chu Wang, Yu Zhao
OBJECTIVES: To investigate the incidence, distribution and radiological characteristics of dural ossification (DO) associated with ossification of ligamentum flavum (OLF) in the thoracic spine. DESIGN: A retrospective radiographical analysis. SETTING: This study was conducted at a single institution in China. PARTICIPANTS: 53 patients with OLF who underwent posterior decompression surgery between January 2011 and July 2015 in a single institution were enrolled in this study...
December 20, 2016: BMJ Open
https://www.readbyqxmd.com/read/27990155/dietary-supplement-comprised-of-%C3%AE-carotene-vitamin-c-vitamin-e-and-magnesium-failure-to-prevent-music-induced-temporary-threshold-shift
#11
C G Le Prell, A Fulbright, C Spankovich, S K Griffiths, E Lobarinas, K C M Campbell, P J Antonelli, G E Green, K Guire, J M Miller
This study examined potential prevention of music-induced temporary threshold shift (TTS) in normal-hearing participants. A dietary supplement composed of β-carotene, vitamins C and E, and magnesium was assessed using a randomized, placebo-controlled, double-blind study design. Dosing began 3 days prior to the music exposure with the final dose consumed approximately 30-min pre-exposure. There were no group differences in post-exposure TTS or music-induced decreases in distortion product otoacoustic emission (DPOAE) amplitude...
May 2016: Audiology and Neurotology. Extra
https://www.readbyqxmd.com/read/27943095/predictors-of-inadequate-weight-loss-after-laparoscopic-gastric-bypass-for-morbid-obesity
#12
Waleed Al-Khyatt, Rebecca Ryall, Paul Leeder, Javed Ahmed, Sherif Awad
BACKGROUND: Laparoscopic Roux-en-Y gastric bypass (LRYGB) is an effective treatment for morbid obesity resulting in approx. 70% excess weight loss (EWL) at 1-2 years. The aim of this study was to identify factors predictive of inadequate EWL following primary LRYGB. METHODS: Data on consecutive patients who underwent primary LRYGB between September 2009 and March 2013 were collected prospectively. The effects of age, gender, baseline body mass index (BMI), preoperative EWL, length of time between initial consultation and surgery (TtS), presence of diabetes mellitus (DM), arthritis, obstructive sleep apnea (OSA) and postoperative length of hospital stay (LOS) on EWL at 12 months were studied...
December 10, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27928880/a-novel-clinical-score-intertak-diagnostic-score-to-differentiate-takotsubo-syndrome-from-acute-coronary-syndrome-results-from-the-international-takotsubo-registry
#13
Jelena R Ghadri, Victoria L Cammann, Stjepan Jurisic, Burkhardt Seifert, L Christian Napp, Johanna Diekmann, Dana Roxana Bataiosu, Fabrizio D'Ascenzo, Katharina J Ding, Annahita Sarcon, Elycia Kazemian, Tanja Birri, Frank Ruschitzka, Thomas F Lüscher, Christian Templin
AIMS: Clinical presentation of takotsubo syndrome (TTS) mimics acute coronary syndrome (ACS) and does not allow differentiation. We aimed to develop a clinical score to estimate the probability of TTS and to distinguish TTS from ACS in the acute stage. METHODS AND RESULTS: Patients with TTS were recruited from the International Takotsubo Registry ( www.takotsubo-registry.com) and ACS patients from the leading hospital in Zurich. A multiple logistic regression for the presence of TTS was performed in a derivation cohort (TTS, n = 218; ACS, n = 436)...
December 7, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27917309/deutetrabenazine-in-tics-associated-with-tourette-syndrome
#14
Joseph Jankovic, Joohi Jimenez-Shahed, Cathy Budman, Barbara Coffey, Tanya Murphy, David Shprecher, David Stamler
BACKGROUND: Deutetrabenazine, an inhibitor of vesicular monoamine transporter type 2 (VMAT2) depletes presynaptic dopamine and is useful in the treatment of hyperkinetic movement disorders. This study explored the safety, tolerability, and preliminary efficacy of deutetrabenazine in adolescents with moderate-to-severe tics associated with Tourette syndrome (TS). METHODS: In this open-label study of 12-18-year-old patients with TS-related tics, deutetrabenazine was titrated up to 36 mg/day over 6 weeks to adequately suppress tics without bothersome adverse effects (AEs), followed by maintenance at optimal dose for 2 weeks...
2016: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/27916698/cellular-mechanisms-of-noise-induced-hearing-loss
#15
Arwa Kurabi, Elizabeth M Keithley, Gary D Housley, Allen F Ryan, Ann C-Y Wong
Exposure to intense sound or noise can result in purely temporary threshold shift (TTS), or leave a residual permanent threshold shift (PTS) along with alterations in growth functions of auditory nerve output. Recent research has revealed a number of mechanisms that contribute to noise-induced hearing loss (NIHL). The principle cause of NIHL is damage to cochlear hair cells and associated synaptopathy. Contributions to TTS include reversible damage to hair cell (HC) stereocilia or synapses, while moderate TTS reflects protective purinergic hearing adaptation...
December 2, 2016: Hearing Research
https://www.readbyqxmd.com/read/27893698/influence-of-acoustic-overstimulation-on-the-central-auditory-system-an-functional-magnetic-resonance-imaging-fmri-study
#16
Tomasz Wolak, Katarzyna Cieśla, Mateusz Rusiniak, Adam Piłka, Monika Lewandowska, Agnieszka Pluta, Henryk Skarżyński, Piotr H Skarżyński
BACKGROUND The goal of the fMRI experiment was to explore the involvement of central auditory structures in pathomechanisms of a behaviorally manifested auditory temporary threshold shift in humans. MATERIAL AND METHODS The material included 18 healthy volunteers with normal hearing. Subjects in the exposure group were presented with 15 min of binaural acoustic overstimulation of narrowband noise (3 kHz central frequency) at 95 dB(A). The control group was not exposed to noise but instead relaxed in silence...
November 28, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27884332/thoracostomy-tube-function-not-trajectory-dictates-reintervention
#17
Nathan W Kugler, Thomas W Carver, Paul Knechtges, David Milia, Lawrence Goodman, Jasmeet S Paul
BACKGROUND: Hemothorax and/or pneumothorax can be managed successfully managed with tube thoracostomy (TT) in the majority of cases. Improperly placed tubes are common with rates near 30%. This study aimed to determine whether TT trajectory affects the rate of secondary intervention. METHODS: A retrospective review of all adult trauma patients undergoing TT placement over a 4-y period was performed. TT trajectory was classified as ideal, nonideal, or kinked-based on anterior-posterior chest x-ray...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27877065/poor-adhesion-of-fentanyl-transdermal-patches-may-mimic-end-of-dosage-failure-after-48-hours-and-prompt-early-patch-replacement-in-hospitalized-cancer-pain-patients
#18
Isabelle Arnet, Sabrina Schacher, Eva Balmer, Dieter Koeberle, Kurt E Hersberger
CONTEXT: Renewal of fentanyl transdermal patch (transdermal therapeutic system [TTS]) should occur every 3 days (72 hours) according to manufacturer's guidelines. Some studies mentioned patients reporting end-of-dose failure, and thus, some authors recommend shortening the interval of application to 2 days (48 hours). However, reasons for early replacement are mostly unknown. OBJECTIVES: The objectives of this study were to assess the prevalence of early replacement of fentanyl TTS in a cancer center in Basel, Switzerland, and to assess the reasons for early replacement in stationary patients...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27865983/transdermal-therapeutic-systems-for-memantine-delivery-comparison-of-passive-and-iontophoretic-transport
#19
S Del Río-Sancho, C E Serna-Jiménez, M Sebastián-Morelló, M A Calatayud-Pascual, C Balaguer-Fernández, A Femenía-Font, Y N Kalia, V Merino, A López-Castellano
Memantine is a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist used in the treatment of moderate to severe dementia including the symptoms of Alzheimer's disease (AD). It is administered orally but compliance, swallowing problems and the routine use of multiple medications in elderly AD patients means that an alternative route of administration would be of interest. The aim of the present study was to develop memantine hydrochloride occlusive transdermal therapeutic systems (TTS) for passive and iontophoretic delivery across the skin...
January 30, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27855351/targeted-therapy-and-elderly-people-a-review
#20
REVIEW
Amaury Daste, Camille Chakiba, Charlotte Domblides, Marine Gross-Goupil, Amandine Quivy, Alain Ravaud, Pierre Soubeyran
The use of targeted therapy (TT) has radically changed the outcome of various cancers and introduces the era of personalised medicine. Elderly patients (≥65 years) represent the majority of cancer diagnoses and deaths by age group with an increase expected over the next decade. This group of patients is heterogeneous with three categories of patients: fit, vulnerable and frail, with specific treatment for each subgroup. In this review, we assess safety and efficacy of TT in elderly patients, principally from data of pivotal clinical trials with subgroup analysis, but elderly people represented a small percentage of the total number of patients...
November 14, 2016: European Journal of Cancer
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