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https://www.readbyqxmd.com/read/29349847/increased-pain-sensitivity-in-migraine-and-tension-type-headache-coexistent-with-low-back-pain-a-cross-sectional-population-study
#1
S Ashina, R B Lipton, L Bendtsen, N Hajiyeva, D C Buse, A C Lyngberg, R Jensen
BACKGROUND: Low back pain is common in the general population and in individuals with primary headaches. We assessed the relative frequency of self-reported back pain in persons with and without primary headaches and examined pain sensitivity. METHOD: A population of 796 individuals completed a headache interview based on ICHD criteria and provided data of interest in a self-administered questionnaire. Headache cases were classified into chronic (≥15) (CH) or episodic (<15 headache days/month) (EH)...
January 19, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29346679/risk-stratification-in-takotsubo-syndrome-a-role-of-mitral-annular-plane-systolic-excursion
#2
Ibrahim El-Battrawy, Uzair Ansari, Siegfried Lang, Christian Fastner, Xiaobo Zhou, Martin Borggrefe, Ibrahim Akin
Aims: Takotsubo syndrome (TTS) patients have a higher mortality rate than the general population. Our study was conducted to determine the short- and long-term outcome of TTS patients associated with a significantly compromised mitral annular plane systolic excursion (MAPSE) on hospital admission. Methods and results: Our institutional database constituted a collective of 53 patients diagnosed with TTS between 2003 and 2016. The patients were classified into two groups based on the MAPSE, with those presenting with a MAPSE <1 cm on admission categorized into one group (n = 20, 38%) and those presenting with MAPSE ≥1 cm (n = 33, 62%) categorized into another group...
January 15, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29334328/different-durations-within-the-method-of-best-practice-affect-the-parameters-of-the-speed-duration-relationship
#3
Christoph Triska, Bettina Karsten, Chris Beedie, Bernhard Koller-Zeisler, Alfred Nimmerichter, Harald Tschan
The aim of the study was to determine whether estimates of the speed-duration relationship are affected using different time-trial (TT) field-based testing protocols, where exhaustive times were located within the generally recommended durations of 2-15 min. Ten triathletes (mean ± SD age: 31.0 ± 5.7 years; height: 1.81 ± 0.05 m; body mass: 76.5 ± 6.8 kg) performed two randomly assigned field tests to determine critical speed (CS) and the total distance covered above CS (D´). CS and D´ were obtained using two different protocols comprising three TT that were interspersed by 60 min passive rest...
January 15, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29332067/incidence-of-and-risk-factors-for-residual-anastomoses-in-twin-twin-transfusion-syndrome-treated-with-laser-surgery-a-15-year-single-center-experience
#4
P J C Knijnenburg, F Slaghekke, L S A Tollenaar, J M van Klink, D P Zhao, J M Middeldorp, M C Haak, F J Klumper, D Oepkes, E Lopriore
OBJECTIVES: To evaluate the incidence of residual anastomoses (RA) after laser therapy for twin-twin transfusion syndrome (TTS) and investigate risk factors for incomplete laser surgery. MATERIAL AND METHODS: All available TTS placentas treated with laser at our center between 2002 and 2016 were injected with color dye to assess the presence of RA. We evaluated the incidence of RA over the past 15 years by dividing the cohort into three time periods, and studied the association with risk factors and neonatal outcome...
January 12, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29320303/time-of-day-and-short-duration-high-intensity-exercise-influences-on-coagulation-and-fibrinolysis
#5
Emma Kate Zadow, Cecilia Marie Kitic, Sam Shi Xuan Wu, James William Fell, Murray John Adams
Exercise has been demonstrated to have considerable effects upon haemostasis, with activation dependent upon the duration and intensity of the exercise bout. In addition, markers of coagulation and fibrinolysis have been shown to possess circadian rhythms, peaking within the morning (0600-1200 h). Therefore, the time of day in which exercise is performed may influence the activation of the coagulation and fibrinolytic systems. This study aimed to examine coagulation and fibrinolytic responses to short-duration high-intensity exercise when completed at different times of the day...
January 10, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29317356/comparative-proteomics-of-the-larval-and-adult-stages-of-the-model-cestode-parasite-mesocestoides-corti
#6
Jeferson Camargo de Lima, Karina Mariante Monteiro, Tatiana Noel Basika Cabrera, Gabriela Prado Paludo, Hercules Moura, John R Barr, Arnaldo Zaha, Henrique Bunselmeyer Ferreira
Mesocestoides corti is a widely used model for the study of cestode biology, and its transition from the larval tetrathyridium (TT) stage to the strobilated, adult worm (ST) stage can be induced and followed in vitro. Here, a proteomic approach was used to describe and compare M. corti TT and ST protein repertories. Overall, 571 proteins were identified, 238 proteins in TT samples and 333 proteins in ST samples. Among the identified proteins, 207 proteins were shared by TTs and STs, while 157 were stage-specific, being 31 exclusive from TTs, and 126 from STs...
January 6, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29312758/the-link-between-spontaneous-coronary-artery-dissection-and-takotsubo-cardiomyopathy-analysis-of-the-published-cases
#7
REVIEW
Dario Buccheri, Giulia Zambelli
Spontaneous coronary artery dissection (SCAD) and takotsubo cardiomyopathy (TTS) are two non-atherosclerotic causes of myocardial infarction. They share several common features. Firstly, they have a predilection for the female gender and, in both, the exact mechanism has yet to be fully established. Both they could be responsible for an acute coronary syndrome. Hence, we want to do further consideration based on pathophysiology, literature review, and cases presented affected by both entities up today.
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29281013/characterization-of-a-novel-miia-domain-containing-protein-mdce-in-bradyrhizobium-spp
#8
David Durán, Juan Imperial, José Palacios, Tomás Ruiz-Argüeso, Michael Göttfert, Susanne Zehner, Luis Rey
Several genes coding for proteins with metal ion-inducible autocleavage (MIIA) domains were identified in type III secretion system tts gene clusters from draft genomes of recently isolated Bradyrhizobium spp. MIIA domains have been first described in the effectors NopE1 and NopE2 of Bradyrhizobium diazoefficiens USDA 110. All identified genes are preceded by tts box promoter motifs. The identified proteins contain one or two MIIA domains. A phylogenetic analysis of 35 MIIA domain sequences from 16 Bradyrhizobium strains revealed four groups...
December 21, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29279414/t-tubule-remodeling-and-increased-heterogeneity-of-calcium-release-during-the-progression-to-heart-failure-in-intact-rat-ventricle
#9
Jasleen K Singh, Varderes Barsegyan, Nikhil Bassi, William Marszalec, Shannon Tai, Shruthi Mothkur, Maaz Mulla, Elsa Nico, Yohannes Shiferaw, Gary L Aistrup, John Andrew Wasserstrom
A highly organized transverse-tubule (TT) system is essential to normal Ca2+ cycling and cardiac function. We explored the relationship between the progressive disruption of TTs and resulting Ca2+ cycling during the development of heart failure (HF). Confocal imaging was used to measure Ca2+ transients and 2-D z-stack images in left ventricular epicardial myocytes of intact hearts from spontaneously hypertensive rats (SHR) and Wistar-Kyoto control rats. TT organization was measured as the organizational index (OI) derived from a fast Fourier transform of TT organization...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29251174/reliability-and-validity-of-a-modified-3-minute-all-out-swimming-test-in-elite-swimmers
#10
Lachlan J G Mitchell, David B Pyne, Philo U Saunders, Ben Rattray
Critical speed (CS) testing is useful in monitoring training in swimmers, however, completing a series of time trials (TTs) regularly is time-consuming. The 3-minute test may be a solution with positive initial findings. This investigation examined whether a modified 3-minute test (12 × 25 m) could assess CS and supra-CS distance capacity (D') in swimmers. A series of 12 × 25 m intervals were completed unpaced at maximal effort, interspersed with 5 s rest periods. The model speed = aebt + c was fitted to the data and integrated to calculate D'...
December 17, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/29242100/takotsubo-is-not-a-cardiomyopathy
#11
Francesco Pelliccia, Gianfranco Sinagra, Perry Elliott, Guido Parodi, Cristina Basso, Paolo G Camici
Unraveling the mechanisms underlying Takotsubo (TTS) leads to question the current inclusion of the condition within the spectrum of cardiomyopathies. Indeed, the clinical presentation and pathophysiology of TTS clearly differ from cardiomyopathies, i.e. diseases of heart muscle unexplained by abnormal loading conditions or coronary artery disease, which cannot recover spontaneously and may cause sudden death often in minimally symptomatic individuals or result in a gradual deterioration in ventricular function and end-stage heart failure...
December 9, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29231047/cost-effectiveness-analysis-of-treatments-involving-radioembolization-in-intermediate-stage-hepatocellular-carcinoma
#12
Carla Rognoni, Oriana Ciani, Silvia Sommariva, Rosanna Tarricone
AIM: We evaluated two treatment sequences, transarterial radioembolization followed by transarterial chemoembolization and possibly sorafenib (=TTS) versus transarterial radioembolization followed by sorafenib alone (=TS), to identify the most cost-effective pathway to treat intermediate-stage hepatocellular carcinoma from the Italian healthcare system perspective. MATERIALS & METHODS: A Markov model was developed to project costs and health outcomes for TTS and TS over a lifetime horizon...
December 12, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/29222118/purine-and-pyrimidine-triple-helix-forming-oligonucleotides-recognize-qualitatively-different-target-sites-at-the-ribosomal-dna-locus
#13
Rodrigo Maldonado, Michael Filarsky, Ingrid Grummt, Gernot Längst
Triplexes are non-canonical DNA structures, which are functionally associated with regulation of gene expression through ncRNA targeting to chromatin. Based on the rules of Hoogsteen base pairing, poly-purine sequences of a duplex can potentially form triplex structures with single-stranded oligonucleotides. Prediction of triplex-forming sequences by bioinformatics analyses have revealed enrichment of potential triplex targeting sites (TTS) at regulatory elements, mainly in promoters and enhancers, suggesting a potential function of RNA-DNA triplexes in transcriptional regulation...
December 8, 2017: RNA
https://www.readbyqxmd.com/read/29220311/quantifying-the-effects-of-acute-hypoxic-exposure-on-exercise-performance-and-capacity-a-systematic-review-and-meta-regression
#14
Sanjoy K Deb, Daniel R Brown, Lewis A Gough, Christopher P McLellan, Paul A Swinton, S Andy Sparks, Lars R McNaughton
OBJECTIVE: To quantify the effects of acute hypoxic exposure on exercise capacity and performance, which includes continuous and intermittent forms of exercise. DESIGN: A systematic review was conducted with a three-level mixed effects meta-regression. The ratio of means method was used to evaluate main effects and moderators providing practical interpretations with percentage change. DATA SOURCES: A systemic search was performed using three databases (Google scholar, PubMed and SPORTDiscus)...
December 8, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/29212452/the-effectiveness-of-physiologically-based-early-warning-or-track-and-trigger-systems-after-triage-in-adult-patients-presenting-to-emergency-departments-a-systematic-review
#15
Francesca Wuytack, Pauline Meskell, Aislinn Conway, Fiona McDaid, Nancy Santesso, Fergal G Hickey, Paddy Gillespie, Adam J N Raymakers, Valerie Smith, Declan Devane
BACKGROUND: Changes to physiological parameters precede deterioration of ill patients. Early warning and track and trigger systems (TTS) use routine physiological measurements with pre-specified thresholds to identify deteriorating patients and trigger appropriate and timely escalation of care. Patients presenting to the emergency department (ED) are undiagnosed, undifferentiated and of varying acuity, yet the effectiveness and cost-effectiveness of using early warning systems and TTS in this setting is unclear...
December 6, 2017: BMC Emergency Medicine
https://www.readbyqxmd.com/read/29198979/bone-volume-fraction-and-structural-parameters-for-estimation-of-mechanical-stiffness-and-failure-load-of-human-cancellous-bone-samples-in-vitro-comparison-of-ultrasound-transit-time-spectroscopy-and-x-ray-%C3%AE-ct
#16
Ali Hamed Alomari, Marie-Luise Wille, Christian M Langton
Conventional mechanical testing is the 'gold standard' for assessing the stiffness (N mm-1) and strength (MPa) of bone, although it is not applicable in-vivo since it is inherently invasive and destructive. The mechanical integrity of a bone is determined by its quantity and quality; being related primarily to bone density and structure respectively. Several non-destructive, non-invasive, in-vivo techniques have been developed and clinically implemented to estimate bone density, both areal (dual-energy X-ray absorptiometry (DXA)) and volumetric (quantitative computed tomography (QCT))...
November 30, 2017: Bone
https://www.readbyqxmd.com/read/29197194/the-role-of-self-expandable-metallic-stents-as-bridge-to-surgery-for-the-treatment-of-acute-malignant-colorectal-obstruction-our-experience
#17
Gianpasquale Gallo, Giuseppe Sammarco, Alessandro Paolo Chiriatti, Ferdinando Calabria, Rosario Sacco
INTRODUCTION: Despite the widespread use of screening programs, the colorectal cancer occurs in 7-29% of cases with a bowel obstruction, needing an immediate decompression treatment by emergency surgery; unfortunately, the emergency surgery is characterized by high morbidity and mortality rates. The endoscopic placement of self-expandable metallic stents can be a useful alternative, allowing to decompress the acute obstruction in a short time, in order to correct dehydration, electrolytic imbalance and to improve the overall clinical conditions prior to adequately plan the intervention of elective surgery...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29186682/control-of-gene-expression-in-senescence-through-transcriptional-read-through-of-convergent-protein-coding-genes
#18
Lisa Muniz, Maharshi Krishna Deb, Marion Aguirrebengoa, Sandra Lazorthes, Didier Trouche, Estelle Nicolas
Antisense RNAs are non-coding RNAs that can regulate their corresponding sense RNAs and are generally produced from specific promoters. We uncover here a family of antisense RNAs, named START RNAs, produced during cellular senescence by transcriptional read-through at convergent protein-coding genes. Importantly, START RNAs repress the expression of their corresponding sense RNAs. In proliferative cells, we found that the Pol II elongation rate is limited downstream of TTS at START loci, allowing transcription termination to occur before Pol II reaches the convergent genes, thus preventing antisense RNA production and interference with the expression of the convergent genes...
November 28, 2017: Cell Reports
https://www.readbyqxmd.com/read/29180264/impact-of-persistent-st-elevation-on-outcome-in-patients-with-takotsubo-syndrome-results-from-the-german-italian-stress-cardiomyopathy-geist-registry
#19
Francesco Santoro, Thomas Stiermaier, Nicola Tarantino, Francesca Guastafierro, Tobias Graf, Christian Möller, Luigi F M Di Martino, Holger Thiele, Matteo Di Biase, Ingo Eitel, Natale Daniele Brunetti
BACKGROUND: Potential predictors of clinical complications of Takotsubo syndrome (TTS) are poorly known. Persistent ST-segment elevation (PSTE) may have an impact on outcome similar as previously reported in acute coronary syndrome. The aim of this study was to assess the prevalence and prognostic relevance of PSTE in patients with TTS. METHODS: Two-hundred-sixty-nine consecutive patients were enrolled in an international multicenter registry. PSTE was defined as the documentation of ST-elevation at least for the first 48h of hospitalization...
November 22, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29179734/an-integrated-digital-clinical-approach-to-smoking-cessation-in-lung-cancer-screening-study-protocol-for-a-randomized-controlled-trial
#20
Amanda L Graham, Michael V Burke, Megan A Jacobs, Sarah Cha, Ivana T Croghan, Darrell R Schroeder, James P Moriarty, Bijan J Borah, Donna F Rasmussen, M Jody Brookover, Dale B Suesse, David E Midthun, J Taylor Hays
BACKGROUND: Delivering effective tobacco dependence treatment that is feasible within lung cancer screening (LCS) programs is crucial for realizing the health benefits and cost savings of screening. Large-scale trials and systematic reviews have demonstrated that digital cessation interventions (i.e. web-based and text message) are effective, sustainable over the long-term, scalable, and cost-efficient. Use of digital technologies is commonplace among older adults, making this a feasible approach within LCS programs...
November 28, 2017: Trials
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