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https://www.readbyqxmd.com/read/29153508/patient-characteristics-in-variable-left-ventricular-recovery-from-takotsubo-syndrome
#1
Jae I Kim, Charan Yerasi, Alaa Azzouqa, Edward Koiffman, Gaby Weissman, Zuyue Wang, John Moran, Rebecca Torguson, Lowell F Satler, Augusto D Pichard, Ron Waksman, Joseph Lindsay, Itsik Ben-Dor
BACKGROUND: Takotsubo syndrome (TTS) is a heart failure syndrome which is usually reversible. Factors associated with degree of recovery of left ventricular systolic function in TTS are poorly understood. MATERIALS AND METHODS: We conducted a retrospective analysis of 90 TTS patients treated at our institution from 2006 to 2014. Patients were grouped based on recovery of left ventricular ejection fraction (LVEF) on follow-up transthoracic echocardiogram as left ventricular ejection fraction <50% (partial group) or preserved ejection fraction ≥50% (full group)...
October 5, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29150306/a-proposal-for-a-noninvasive-monitoring-of-sympathetic-nerve-activity-in-patients-with-takotsubo-syndrome
#2
John E Madias
The pathophysiology of takotsubo syndrome (TTS) is still elusive; many hypotheses of its cause have been proposed with a heightened activity of the peripheral autonomic sympathetic nervous system (PASNS) via local norepinephrine release, and direct cardiomyocyte toxicity mediated by blood-borne catecholamines, being among the most currently entertained. Monitoring of PASNS during hospitalization will provide a metric which could be of immense value in unraveling of the pathophysiology and aiding in the management of the patients with TTS by predicting in-hospital complications, long-term outcome, and its recurrence...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29147922/the-effect-of-head-to-head-competition-on-behavioural-thermoregulation-thermophysiological-strain-and-performance-during-exercise-in-the-heat
#3
Jo Corbett, Danny K White, Martin J Barwood, Christopher R D Wagstaff, Michael J Tipton, Terry McMorris, Joseph T Costello
BACKGROUND: It has been suggested that pacing is a thermoregulatory behaviour. We investigated the effect of competition on pacing, performance and thermophysiological strain during exercise in the heat and the psychological factors mediating competition effects. METHOD: Eighteen males (maximum oxygen uptake [V O 2max] 3.69 [0.44] L min(-1)) undertook a preliminary 20-km cool (wet-bulb globe temperature [WBGT] 12 °C) cycling time trial (TT) and three experimental 20-km trials (balanced order): (i) cool TT (CoolSolo); (ii) hot (WBGT 26 °C) TT (HotSolo); (iii) hot head-to-head competition (HotH2H)...
November 17, 2017: Sports Medicine
https://www.readbyqxmd.com/read/29103522/a-systematical-rheological-study-of-polysaccharide-from-sophora-alopecuroides-l-seeds
#4
Yan Wu, Rui Guo, Nannan Cao, Xiangjun Sun, Zhongquan Sui, Qingbin Guo
The rheological properties of polysaccharide (SAP) from Sophora alopecuroides L. seeds were systematically investigated by fitting different models. The steady flow testing indicated that SAP exhibited shear-thinning behaviors, which were enhanced with increasing concentration and decreasing temperature. This was demonstrated quantitatively by Williamson and Arrhenius models. According to the generalized Morris equation, SAP exhibited random coil conformation with the potential to form weak gel-like network...
January 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29092610/temporary-hearing-threshold-shift-in-a-harbor-porpoise-phocoena-phocoena-after-exposure-to-multiple-airgun-sounds
#5
Ronald A Kastelein, Lean Helder-Hoek, Shirley Van de Voorde, Alexander M von Benda-Beckmann, Frans-Peter A Lam, Erwin Jansen, Christ A F de Jong, Michael A Ainslie
In seismic surveys, reflected sounds from airguns are used under water to detect gas and oil below the sea floor. The airguns produce broadband high-amplitude impulsive sounds, which may cause temporary or permanent threshold shifts (TTS or PTS) in cetaceans. The magnitude of the threshold shifts and the hearing frequencies at which they occur depend on factors such as the received cumulative sound exposure level (SELcum), the number of exposures, and the frequency content of the sounds. To quantify TTS caused by airgun exposure and the subsequent hearing recovery, the hearing of a harbor porpoise was tested by means of a psychophysical technique...
October 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29092598/why-is-auditory-frequency-weighting-so-important-in-regulation-of-underwater-noise
#6
Jakob Tougaard, Michael Dähne
A key question related to regulating noise from pile driving, air guns, and sonars is how to take into account the hearing abilities of different animals by means of auditory frequency weighting. Recordings of pile driving sounds, both in the presence and absence of a bubble curtain, were evaluated against recent thresholds for temporary threshold shift (TTS) for harbor porpoises by means of four different weighting functions. The assessed effectivity, expressed as time until TTS, depended strongly on choice of weighting function: 2 orders of magnitude larger for an audiogram-weighted TTS criterion relative to an unweighted criterion, highlighting the importance of selecting the right frequency weighting...
October 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29092538/effects-of-exposure-to-sonar-playback-sounds-3-5-4-1%C3%A2-khz-on-harbor-porpoise-phocoena-phocoena-hearing
#7
Ronald A Kastelein, Lean Helder-Hoek, Shirley Van de Voorde
Safety criteria for naval sonar sounds are needed to protect harbor porpoise hearing. Two porpoises were exposed to sequences of AN/SQS-53C sonar playback sounds (3.5-4.1 kHz, without significant harmonics), at a mean received sound pressure level of 142 dB re 1 μPa, with a duty cycle of 96% (almost continuous). Behavioral hearing thresholds at 4 and 5.7 kHz were determined before and after exposure to the fatiguing sound, in order to quantify temporary threshold shifts (TTSs) and hearing recovery...
October 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29079778/exercise-dependent-formation-of-new-junctions-that-promote-stim1-orai1-assembly-in-skeletal-muscle
#8
Simona Boncompagni, Antonio Michelucci, Laura Pietrangelo, Robert T Dirksen, Feliciano Protasi
Store-operated Ca(2+) entry (SOCE), a ubiquitous mechanism that allows recovery of Ca(2+) ions from the extracellular space, has been proposed to limit fatigue during repetitive skeletal muscle activity. However, the subcellular location for SOCE in muscle fibers has not been unequivocally identified. Here we show that exercise drives a significant remodeling of the sarcotubular system to form previously unidentified junctions between the sarcoplasmic reticulum (SR) and transverse-tubules (TTs). We also demonstrate that these new SR-TT junctions contain the molecular machinery that mediate SOCE: stromal interaction molecule-1 (STIM1), which functions as the SR Ca(2+) sensor, and Orai1, the Ca(2+)-permeable channel in the TT...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29074282/clinical-characteristics-of-patients-with-takotsubo-syndrome-diagnosed-without-coronary-artery-evaluation-a-retrospective-nationwide-study
#9
Toshiaki Isogai, Hiroki Matsui, Hiroyuki Tanaka, Kiyohide Fushimi, Hideo Yasunaga
BACKGROUND: Although the current diagnostic criteria require that culprit coronary artery disease be ruled out before the diagnosis of Takotsubo syndrome (TTS) is made, performing coronary artery evaluation (CAE) in patients with serious backgrounds is sometimes challenging. METHODS: We conducted a retrospective cohort study using the Diagnosis Procedure Combination database in Japan. We identified patients in whom TTS was diagnosed at Japanese Circulation Society board-certified teaching hospitals from April 2011 to March 2014 and divided eligible patients into those who underwent CAE (coronary angiography or coronary computed tomography angiography) during hospitalization and those who did not...
October 23, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29060667/tonguetospeech-tts-wearable-wireless-assistive-device-for-augmented-speech
#10
Nicholas Marjanovic, Giacomo Piccinini, Kevin Kerr, Hananeh Esmailbeigi
Speech is an important aspect of human communication; individuals with speech impairment are unable to communicate vocally in real time. Our team has developed the TongueToSpeech (TTS) device with the goal of augmenting speech communication for the vocally impaired. The proposed device is a wearable wireless assistive device that incorporates a capacitive touch keyboard interface embedded inside a discrete retainer. This device connects to a computer, tablet or a smartphone via Bluetooth connection. The developed TTS application converts text typed by the tongue into audible speech...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29054252/methodology-on-quantification-of-sonication-duration-for-safe-application-of-mr-guided-focused-ultrasound-for-liver-tumour-ablation
#11
Senay Mihcin, Ioannis Karakitsios, Nhan Le, Jan Strehlow, Daniel Demedts, Michael Schwenke, Sabrina Haase, Tobias Preusser, Andreas Melzer
BACKGROUND AND OBJECTIVE: Magnetic Resonance Guided Focused Ultrasound (MRgFUS) for liver tumour ablation is a challenging task due to motion caused by breathing and occlusion due the ribcage between the transducer and the tumour. To overcome these challenges, a novel system for liver tumour ablation during free breathing has been designed. METHODS: The novel TRANS-FUSIMO Treatment System (TTS, EUFP7) interacts with a Magnetic Resonance (MR) scanner and a focused ultrasound transducer to sonicate to a moving target in liver...
December 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29051615/time-controllable-nkcc1-knockdown-replicates-reversible-hearing-loss-in-postnatal-mice
#12
Takahisa Watabe, Ming Xu, Miho Watanabe, Junichi Nabekura, Taiga Higuchi, Karin Hori, Mitsuo P Sato, Fumiaki Nin, Hiroshi Hibino, Kaoru Ogawa, Masatsugu Masuda, Kenji F Tanaka
Identification of the causal effects of specific proteins on recurrent and partially reversible hearing loss has been difficult because of the lack of an animal model that provides reversible gene knockdown. We have developed the transgenic mouse line Actin-tTS::Nkcc1 (tetO/tetO) for manipulatable expression of the cochlear K(+) circulation protein, NKCC1. Nkcc1 transcription was blocked by the binding of a tetracycline-dependent transcriptional silencer to the tetracycline operator sequences inserted upstream of the Nkcc1 translation initiation site...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29039623/the-challenge-of-takotsubo-syndrome-heterogeneity-of-clinical-features
#13
Susanne Anna Schlossbauer, Jelena-Rima Ghadri, Frank Scherff, Christian Templin
Takotsubo syndrome (TTS) was first described in 1991 as a rare, spontaneous and completely reversible left ventricular regional systolic dysfunction. Today the incidence of TTS is estimated at 2% in patients with an initial diagnosis of acute coronary syndrome (ACS). Notably, the incidence can be as high as 5.9 to 7.5% in female patients. TTS occurs predominantly in postmenopausal women, but both sexes may be affected, at any age. Acute chest pain or dyspnoea is a characteristic symptom of TTS, but initial presentation can also include more severe disease manifestation such as acute heart failure with pulmonary oedema or haemodynamic instability, especially in an in-hospital setting...
October 17, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29035591/effect-of-intensified-endurance-training-on-pacing-and-performance-in-4000m-cycling-time-trials
#14
Alice M Wallett, Amy L Woods, Nathan G Versey, Laura A Garvican-Lewis, Marijke Welvaert, Kevin G Thompson
Studies examining pacing strategies during 4000m cycling time-trials (TTs) typically ensure participants are not pre-fatigued, however competitive cyclists often undertake TTs when already pre-fatigued. This study aimed to determine how TT pacing strategies and sprint characteristics of cyclists change during an intensified training period (mesocycle). Thirteen cyclists, regularly competing in A and B grade cycling races and consistently training (>10 h·wk-1 for 4±1 years), completed a six-week training mesocycle...
October 16, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29033847/a-monetary-reward-alters-pacing-but-not-performance-in-competitive-cyclists
#15
Sabrina Skorski, Kevin G Thompson, Richard J Keegan, Tim Meyer, Chris R Abbiss
Money has frequently been used as an extrinsic motivator since it is assumed that humans are willing to invest more effort for financial reward. However, the influence of a monetary reward on pacing and performance in trained athletes is not well-understood. Therefore, the aim of this study was to analyse the influence of a monetary reward in well-trained cyclists on their pacing and performance during short and long cycling time trials (TT). Twentythree cyclists (6 ♀, 17 ♂) completed 4 self-paced time trials (TTs, 2 short: 4 km and 6 min; 2 long: 20 km and 30 min); in a randomized order...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29026366/trigeminal-trophic-syndrome-associated-with-the-use-of-synthetic-marijuana
#16
Fawad A Khan, Rinu Manacheril, Robin Ulep, Julie E Martin, Anil Chimakurthy
BACKGROUND: Trigeminal trophic syndrome (TTS) is an uncommon disorder of the trigeminal nerve tract and trigeminal brainstem nucleus. The syndrome is characterized by a triad of unilateral crescentic ulcers with anesthesia and paresthesias of the involved trigeminal dermatomes. CASE REPORT: A 24-year-old right-handed black female presented to our emergency department with a 4-week history of rapidly progressive painless desquamation/denudation of skin over her right face and scalp...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29022364/fast-wandering-takotsubo-syndrome-atypical-mixed-evolution-from-apical-to-mid-ventricular-ballooning
#17
Grazia Casavecchia, Stefano Zicchino, Matteo Gravina, Guglielmo Maulucci, Vincenzo Manuppelli, Nicola Tarantino, Antonio Ruggiero, Dolores Russo, Francesco Santoro, Luca Macarini, Matteo Di Biase, Natale Daniele Brunetti
We report the case of a 53-year-old woman admitted for typical chest pain and a diagnosis of Takotsubo syndrome (TTS). Initial echocardiographic presentation was characterized by apical and mid-ventricular akinesis and basal hyper-kinesis. Unexpectedly, later after admission, echocardiography showed recovered apical akinesis with an apparent 'migration' of systolic dysfunction to mid-ventricular segment and hyper-kinesis of apical and basal segments. One week after admission, left ventricular contractility completely recovered and cardiac magnetic resonance imaging did not show signs of subendocardial late-enhancement and myocardial edema...
October 12, 2017: Future Cardiology
https://www.readbyqxmd.com/read/28989094/impact-of-time-to-surgery-in-the-outcome-of-patients-with-liver-resection-for-bclc-0-a-stage-hepatocellular-carcinoma
#18
Chetana Lim, Prashant Bhangui, Chady Salloum, Concepción Gómez-Gavara, Eylon Lahat, Alain Luciani, Philippe Compagnon, Julien Calderaro, Cyrille Feray, Daniel Azoulay
BACKGROUND & AIMS: The Barcelona Clinic Liver Cancer (BCLC) guidelines recommend resection for very early and early single hepatocellular carcinoma (HCC) patients. It is not known whether a delay in resection from the time of diagnosis (the time to surgery [TTS], i.e. the elapsed time from diagnosis to surgery) affects outcomes. We aim to evaluate the impact of TTS on recurrence and survival outcomes in patients with HCC. METHODS: All patients resected for BCLC stage 0-A single HCC from 2006 to 2016 were studied to evaluate the impact of TTS on recurrence rate, recurrence-free survival (RFS), transplantability following recurrence, and intention-to-treat overall survival (ITT-OS)...
October 6, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28988016/characterisation-of-the-immune-related-transcriptome-in-resected-biliary-tract-cancers
#19
Michele Ghidini, Luciano Cascione, Pietro Carotenuto, Andrea Lampis, Francesco Trevisani, Maria Chiara Previdi, Jens C Hahne, Ian Said-Huntingford, Maya Raj, Alessandro Zerbi, Claudia Mescoli, Umberto Cillo, Massimo Rugge, Massimo Roncalli, Guido Torzilli, Lorenza Rimassa, Armando Santoro, Nicola Valeri, Matteo Fassan, Chiara Braconi
Although biliary tract cancers (BTCs) are known to have an inflammatory component, a detailed characterisation of immune-related transcripts has never been performed. In these studies, nCounter PanCancer Immune Profiling Panel was used to assess the expression of 770 immune-related transcripts in the tumour tissues (TTs) and matched adjacent tissues (ATs) of resected BTCs. Cox regression analysis and Kaplan-Meier methods were used to correlate findings with relapse-free survival (RFS). The first analysis in the TT and AT of an exploratory set (n = 22) showed deregulation of 39 transcripts associated with T-cell activation...
October 5, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28975517/the-effects-of-hyperoxia-on-sea-level-exercise-performance-training-and-recovery-a-meta-analysis
#20
REVIEW
Matthew M Mallette, Desmond G Stewart, Stephen S Cheung
BACKGROUND: Acute exercise performance can be limited by arterial hypoxemia, such that hyperoxia may be an ergogenic aid by increasing tissue oxygen availability. Hyperoxia during a single bout of exercise performance has been examined using many test modalities, including time trials (TTs), time to exhaustion (TTE), graded exercise tests (GXTs), and dynamic muscle function tests. Hyperoxia has also been used as a long-term training stimulus or a recovery intervention between bouts of exercise...
October 3, 2017: Sports Medicine
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