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https://www.readbyqxmd.com/read/27928880/a-novel-clinical-score-intertak-diagnostic-score-to-differentiate-takotsubo-syndrome-from-acute-coronary-syndrome-results-from-the-international-takotsubo-registry
#1
Jelena R Ghadri, Victoria L Cammann, Stjepan Jurisic, Burkhardt Seifert, L Christian Napp, Johanna Diekmann, Dana Roxana Bataiosu, Fabrizio D'Ascenzo, Katharina J Ding, Annahita Sarcon, Elycia Kazemian, Tanja Birri, Frank Ruschitzka, Thomas F Lüscher, Christian Templin
AIMS: Clinical presentation of takotsubo syndrome (TTS) mimics acute coronary syndrome (ACS) and does not allow differentiation. We aimed to develop a clinical score to estimate the probability of TTS and to distinguish TTS from ACS in the acute stage. METHODS AND RESULTS: Patients with TTS were recruited from the International Takotsubo Registry ( www.takotsubo-registry.com) and ACS patients from the leading hospital in Zurich. A multiple logistic regression for the presence of TTS was performed in a derivation cohort (TTS, n = 218; ACS, n = 436)...
December 7, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27917309/deutetrabenazine-in-tics-associated-with-tourette-syndrome
#2
Joseph Jankovic, Joohi Jimenez-Shahed, Cathy Budman, Barbara Coffey, Tanya Murphy, David Shprecher, David Stamler
BACKGROUND: Deutetrabenazine, an inhibitor of vesicular monoamine transporter type 2 (VMAT2) depletes presynaptic dopamine and is useful in the treatment of hyperkinetic movement disorders. This study explored the safety, tolerability, and preliminary efficacy of deutetrabenazine in adolescents with moderate-to-severe tics associated with Tourette syndrome (TS). METHODS: In this open-label study of 12-18-year-old patients with TS-related tics, deutetrabenazine was titrated up to 36 mg/day over 6 weeks to adequately suppress tics without bothersome adverse effects (AEs), followed by maintenance at optimal dose for 2 weeks...
2016: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/27916698/cellular-mechanisms-of-noise-induced-hearing-loss
#3
Arwa Kurabi, Elizabeth M Keithley, Gary D Housley, Allen F Ryan, Ann C-Y Wong
Exposure to intense sound or noise can result in purely temporary threshold shift (TTS), or leave a residual permanent threshold shift (PTS) along with alterations in growth functions of auditory nerve output. Recent research has revealed a number of mechanisms that contribute to noise-induced hearing loss (NIHL). The principle cause of NIHL is damage to cochlear hair cells and associated synaptopathy. Contributions to TTS include reversible damage to hair cell (HC) stereocilia or synapses, while moderate TTS reflects protective purinergic hearing adaptation...
December 1, 2016: Hearing Research
https://www.readbyqxmd.com/read/27893698/influence-of-acoustic-overstimulation-on-the-central-auditory-system-an-functional-magnetic-resonance-imaging-fmri-study
#4
Tomasz Wolak, Katarzyna Cieśla, Mateusz Rusiniak, Adam Piłka, Monika Lewandowska, Agnieszka Pluta, Henryk Skarżyński, Piotr H Skarżyński
BACKGROUND The goal of the fMRI experiment was to explore the involvement of central auditory structures in pathomechanisms of a behaviorally manifested auditory temporary threshold shift in humans. MATERIAL AND METHODS The material included 18 healthy volunteers with normal hearing. Subjects in the exposure group were presented with 15 min of binaural acoustic overstimulation of narrowband noise (3 kHz central frequency) at 95 dB(A). The control group was not exposed to noise but instead relaxed in silence...
November 28, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27884332/thoracostomy-tube-function-not-trajectory-dictates-reintervention
#5
Nathan W Kugler, Thomas W Carver, Paul Knechtges, David Milia, Lawrence Goodman, Jasmeet S Paul
BACKGROUND: Hemothorax and/or pneumothorax can be managed successfully managed with tube thoracostomy (TT) in the majority of cases. Improperly placed tubes are common with rates near 30%. This study aimed to determine whether TT trajectory affects the rate of secondary intervention. METHODS: A retrospective review of all adult trauma patients undergoing TT placement over a 4-y period was performed. TT trajectory was classified as ideal, nonideal, or kinked-based on anterior-posterior chest x-ray...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27877065/poor-adhesion-of-fentanyl-transdermal-patches-may-mimic-end-of-dosage-failure-after-48-hours-and-prompt-early-patch-replacement-in-hospitalized-cancer-pain-patients
#6
Isabelle Arnet, Sabrina Schacher, Eva Balmer, Dieter Koeberle, Kurt E Hersberger
CONTEXT: Renewal of fentanyl transdermal patch (transdermal therapeutic system [TTS]) should occur every 3 days (72 hours) according to manufacturer's guidelines. Some studies mentioned patients reporting end-of-dose failure, and thus, some authors recommend shortening the interval of application to 2 days (48 hours). However, reasons for early replacement are mostly unknown. OBJECTIVES: The objectives of this study were to assess the prevalence of early replacement of fentanyl TTS in a cancer center in Basel, Switzerland, and to assess the reasons for early replacement in stationary patients...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27865983/transdermal-therapeutic-systems-for-memantine-delivery-comparison-of-passive-and-iontophoretic-transport
#7
S Del Río-Sancho, C E Serna-Jiménez, M Sebastián-Morelló, M A Calatayud-Pascual, C Balaguer-Fernández, A Femenía-Font, Y N Kalia, V Merino, A López-Castellano
Memantine is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist used in the treatment of moderate to severe dementia including the symptoms of Alzheimer's disease (AD). It is administered orally but compliance, swallowing problems and the routine use of multiple medications in elderly AD patients means that an alternative route of administration would be of interest. The aim of the present study was to develop memantine hydrochloride occlusive transdermal therapeutic systems (TTS) for passive and iontophoretic delivery across the skin...
November 16, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27855351/targeted-therapy-and-elderly-people-a-review
#8
REVIEW
Amaury Daste, Camille Chakiba, Charlotte Domblides, Marine Gross-Goupil, Amandine Quivy, Alain Ravaud, Pierre Soubeyran
The use of targeted therapy (TT) has radically changed the outcome of various cancers and introduces the era of personalised medicine. Elderly patients (≥65 years) represent the majority of cancer diagnoses and deaths by age group with an increase expected over the next decade. This group of patients is heterogeneous with three categories of patients: fit, vulnerable and frail, with specific treatment for each subgroup. In this review, we assess safety and efficacy of TT in elderly patients, principally from data of pivotal clinical trials with subgroup analysis, but elderly people represented a small percentage of the total number of patients...
November 14, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27849127/commentary-on-the-regulatory-implications-of-noise-induced-cochlear-neuropathy
#9
Robert A Dobie, Larry E Humes
OBJECTIVE: A discussion on whether recent research on noise-induced cochlear neuropathy in rodents justifies changes in current regulation of occupational noise exposure. DESIGN: Informal literature review and commentary, relying on literature found in the authors' files. No formal literature search was performed. STUDY SAMPLE: Published literature on temporary threshold shift (TTS) and cochlear pathology, in humans and experimental animals, as well as the regulations of the US Occupational Safety and Health Administration (OSHA)...
November 16, 2016: International Journal of Audiology
https://www.readbyqxmd.com/read/27847675/an-orthopedic-hospitalist-comanaged-hip-fracture-service-reduces-inpatient-length-of-stay
#10
Daniel N Bracey, Tunc C Kiymaz, David C Holst, Kamran S Hamid, Johannes F Plate, Erik C Summers, Cynthia L Emory, Riyaz H Jinnah
INTRODUCTION: Hip fractures are common in the elderly patients with an incidence of 320 000 fractures/year in the United States, representing a health-care cost of US$9 to 20 billion. Hip fracture incidence is projected to increase dramatically. Hospitals must modify clinical models to accommodate this growing burden. Comanagement strategies are reported in the literature, but few have addressed orthopedic-hospitalist models. An orthopedic-hospitalist comanagement (OHC) service was established at our hospital to manage hip fracture patients...
December 2016: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/27834492/single-and-combined-effects-of-beetroot-crystals-and-sodium-bicarbonate-on-4-km-cycling-time-trial-performance
#11
Marcus J Callahan, Evelyn B Parr, John A Hawley, Louise M Burke
When ingested alone, beetroot juice and sodium bicarbonate are ergogenic for high-intensity exercise performance. This study sought to determine the independent and combined effects of these supplements. Eight endurance trained (V̇O2max 65 mL·kg·min(-1)) male cyclists completed four x 4-km time trials (TT) in a double-blind Latin square design supplementing with beetroot crystals (BC) for 3 days (15 g.day(-1) + 15 g 1 h prior to TT, containing 300 mg nitrate per 15 g), bicarbonate (Bi 0.3 g·kg(-1) body mass [BM] in 5 doses every 15 min from 2...
November 11, 2016: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/27794299/low-frequency-temporary-threshold-shift-not-observed-in-spotted-or-ringed-seals-exposed-to-single-air-gun-impulses
#12
Colleen Reichmuth, Asila Ghoul, Jillian M Sills, Andrew Rouse, Brandon L Southall
Underwater hearing thresholds were measured at 100 Hz in trained spotted (Phoca largha) and ringed seals (Pusa hispida) before and immediately following voluntary exposure to impulsive noise from a seismic air gun. Auditory responses were determined from psychoacoustic data and behavioral responses were scored from video recordings. Four successive exposure conditions of increasing level were tested, with received unweighted sound exposure levels from 165 to 181 dB re 1 μPa(2) s and peak-to-peak sound pressures from 190 to 207 dB re 1 μPa...
October 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27793416/impact-of-time-to-surgery-after-neoadjuvant-chemotherapy-in-operable-breast-cancer-patients
#13
C Omarini, G Guaitoli, S Noventa, A Andreotti, A Gambini, E Palma, S Papi, G Tazzioli, S Balduzzi, M Dominici, S Cascinu, F Piacentini
BACKGROUND: The optimal time interval between the end of neoadjuvant systemic therapy (NST) and breast surgery is still unclear. It is not known if a delay in surgery might influence the benefit of primary chemotherapy. The aim of this study is to evaluate the relationship between time to surgery (TTS) and survival outcomes. PATIENTS AND METHODS: According to TTS, women with diagnosis of BC treated with NST were divided into two cohorts: group A = 21 days or fewer and group B = longer than 21 days...
October 20, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27734078/transanal-tube-for-the-prevention-of-anastomotic-leakage-after-rectal-cancer-surgery-a-systematic-review-and-meta-analysis
#14
Wen-Tao Zhao, Ning-Ning Li, Dan He, Jin-Yan Feng
BACKGROUND: Transanal tubes (TTs) have been used to prevent and reduce anastomotic leakage after rectal cancer surgery. The aim of this review was to investigate the efficacy and safety of the TT. METHODS: A systematic literature search was performed to identify randomized controlled trials and controlled clinical trials assessing the clinical efficacy and safety of TTs in rectal cancer surgery. RESULTS: Seven trials with 1609 participants were included...
October 12, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27713701/improvements-in-cycling-time-trial-performance-are-not-sustained-following-the-acute-provision-of-challenging-and-deceptive-feedback
#15
Hollie S Jones, Emily L Williams, David Marchant, S Andy Sparks, Craig A Bridge, Adrian W Midgley, Lars R Mc Naughton
The provision of performance-related feedback during exercise is acknowledged as an influential external cue used to inform pacing decisions. The provision of this feedback in a challenging or deceptive context allows research to explore how feedback can be used to improve performance and influence perceptual responses. However, the effects of deception on both acute and residual responses have yet to be explored, despite potential application for performance enhancement. Therefore, this study investigated the effects of challenging and deceptive feedback on perceptual responses and performance in self-paced cycling time trials (TT) and explored whether changes in performance are sustained in a subsequent TT following the disclosure of the deception...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27692531/identification-and-quantification-of-nuisance-odors-at-a-trash-transfer-station
#16
Jane Curren, Samantha A Hallis, Cherie Cher L Snyder, Irwin Mel H Suffet
The objective of this study was to evaluate the effectiveness of a modified Odor Profile Method (OPM) at a trash transfer station (TTS). An updated Landfill Odor Wheel was used to define odor character and distinguish among odor sources. The Flavor Profile Analysis (FPA) intensity scale was used to rank the relative intensity of the various odor characters defined by the odor wheel and to understand how each odor profile changed off site. Finally, the odor wheel was used to select the appropriate chemical analysis to identify the odorants causing the odors identified by the human panelists...
September 27, 2016: Waste Management
https://www.readbyqxmd.com/read/27679934/development-and-validation-of-a-simple-integer-risk-score-for-prediction-of-in-hospital-mortality-following-takotsubo-syndrome
#17
Ahmed N Mahmoud, Mohammad Al-Ani, Marwan Saad, Akram Y Elgendy, Islam Y Elgendy
BACKGROUND: Data regarding the characteristics associated with worse outcomes in Takotsubo syndrome (TTS) patients is lacking. METHODS AND OBJECTIVES: The National Inpatient Sample (NIS) 2012 database was utilized to calculate a risk score for in-hospital mortality following TTS that was internally and externally validated in both 2012 and 2013 databases, respectively. RESULTS: The incidences of in-hospital mortality in the 2012 development sample were 0...
September 24, 2016: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/27678209/incidence-and-predictors-of-stroke-during-the-index-event-in-an-ethnically-diverse-takotsubo-cardiomyopathy-population
#18
A Dias, E Franco, S Janzer, Nikoloz Koshkelashvili, V Bhalla, Manolo Rubio, Sarah Amanullah, Kathy Hebert, Vincent M Figueredo
Takotsubo cardiomyopathy (TTS) is a peculiar clinical condition often affecting postmenopausal women after a stressful trigger. The underlying mechanisms have not been completely elucidated but several hypotheses have been advanced, with catecholamine cardiotoxicity, microvascular dysfunction and coronary artery spasm each suggested to play a role. The incidence of stroke after TTS appears to range from 0% to 7.7%, and interestingly TTS has been described as both a cause and a complication of stroke. We sought to assess the incidence and predictors of stroke during the index event (peri-index event stroke) in a heterogeneous TTS population...
July 2016: Functional Neurology
https://www.readbyqxmd.com/read/27671703/clinical-implications-of-hepatobiliary-scintigraphy-and-ultrasound-in-the-diagnosis-of-acute-cholecystitis
#19
Limael E Rodriguez, Luis E Santaliz-Ruiz, Gabriel De La Torre-Bisot, Giovanni Gonzalez, Miguel A Serpa, Felipe Sanchez-Gaetan, Jorge L Martinez-Trabal, Julio A Peguero-Rivera, Guillermo Bolanos-Avila
BACKGROUND: We assess the performance of ultrasound (US) and hepatobiliary scintigraphy (HIDA) as confirmatory studies in acute cholecystitis (AC) and demonstrate our current imaging protocol's impact on outcomes. STUDY DESIGN: Between January 2013 to July 2014, 117 patients were admitted through the emergency room with a preliminary diagnosis of AC. Overall, 106/117 (91%) of the patients received US preadmission and 34/117 (29%) received a HIDA post admission. Primary end points included: 1) diagnostic test reliability for AC, and 2) outcome and quality measures (time to surgery, LOS, costs, etc...
November 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27666410/incidence-and-predictors-of-stroke-during-the-index-event-in-an-ethnically-diverse-takotsubo-cardiomyopathy-population
#20
A Dias, E Franco, S Janzer, Nikoloz Koshkelashvili, V Bhalla, Manolo Rubio, Sarah Amanullah, Kathy Hebert, Vincent M Figueredo
Takotsubo cardiomyopathy (TTS) is a peculiar clinical condition often affecting postmenopausal women after a stressful trigger. The underlying mechanisms have not been completely elucidated but several hypotheses have been advanced, with catecholamine cardiotoxicity, microvascular dysfunction and coronary artery spasm each suggested to play a role. The incidence of stroke after TTS appears to range from 0% to 7.7%, and interestingly TTS has been described as both a cause and a complication of stroke. We sought to assess the incidence and predictors of stroke during the index event (peri-index event stroke) in a heterogeneous TTS population...
September 26, 2016: Functional Neurology
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