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https://www.readbyqxmd.com/read/29332197/identification-as-a-mutation-carrier-and-effects-on-life-according-to-experiences-of-finnish-male-brca1-2-mutation-carriers
#1
Outi Kajula, Outi Kuismin, Helvi Kyngäs
Earlier studies have explored post-identification experiences of male BRCA1/2 mutation carriers, but more detailed knowledge of both their experiences and effects of identification as a carrier on their lives is required to improve genetic counseling. Thus, the aim of this study was to acquire deeper and broader insights into their experiences. Qualitative data were collected from theme-based interviews with 31 men carrying BRCA1/2 mutations in Finland, and analyzed using inductive content analysis. Three categories of the participants' responses to identification as BRCA1/2 mutation carriers were identified (personal, offspring-related and related to other relatives), mainly concerning issues associated with cancer, hereditary transmission of their mutations, and life decisions...
January 13, 2018: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29332048/frequency-of-cardiovascular-genetic-risk-factors-in-a-calabrian-population-and-their-effects-on-dementia
#2
Raffaele Maletta, Nicoletta Smirne, Livia Bernardi, Maria Anfossi, Maura Gallo, Maria Elena Conidi, Rosanna Colao, Gianfranco Puccio, Sabrina A M Curcio, Valentina Laganà, Francesca Frangipane, Chiara Cupidi, Maria Mirabelli, Franca Vasso, Giusi Torchia, Maria G Muraca, Raffaele Di Lorenzo, Giuseppina Rose, Alberto Montesanto, Giuseppe Passarino, Amalia C Bruni
BACKGROUND: Several genetic variants playing a key role in cholesterol levels, blood pressure, and vascular dysfunction influence the risk of Alzheimer's disease (AD) and vascular dementia (VaD). The many meta-analysis studies carried out on large numbers of samples in different populations have not provided clear results to date, because a trans-ethnic shift of risk genotypes in different populations is often observed. OBJECTIVES: To determine genotypes allele frequencies of the polymorphisms most frequently identified to be correlated with cardio-cerebrovascular disease and AD in a Southern Italy population and to investigate their possible association with dementia...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29331992/effectiveness-of-interventions-for-reducing-non-occupational-sedentary-behaviour-in-adults-and-older-adults-a-systematic-review-and-meta-analysis
#3
REVIEW
Nipun Shrestha, Jozo Grgic, Glen Wiesner, Alexandra Parker, Hrvoje Podnar, Jason A Bennie, Stuart J H Biddle, Zeljko Pedisic
BACKGROUND: No systematic reviews of the effectiveness of interventions for reducing non-occupational sedentary behaviour are available. Therefore, the aim of this systematic review was to assess the effectiveness of interventions for reducing non-occupational sedentary behaviour in adults and older adults. METHODS: An electronic search of nine databases was performed. Randomised controlled trials (RCT) and cluster RCTs among adults testing the effectiveness of interventions aimed to reduce non-occupational sedentary behaviour were considered for inclusion...
January 13, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29331849/sociodemographic-lifestyle-and-health-determinants-of-suicidal-behaviour-in-malaysia
#4
Yong Kang Cheah, Mohd Azahadi, Siew Nooi Phang, Noor Hazilah Abd Manaf
Suicide has become a serious matter in both developed and developing countries. The objective of the present study is to examine the factors affecting suicidal behaviour among adults in Malaysia. A nationally representative data which consists of 10,141 respondents is used for analysis. A trivariate probit model is utilised to identify the probability of having suicide ideation, suicide plan and suicide attempt. Results of the regression analysis show that to ensure unbiased estimates, a trivariate probit model should be used instead of three separate probit models...
January 5, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29331276/analyzing-recommender-systems-for-health-promotion-using-a-multidisciplinary-taxonomy-a-scoping-review
#5
Santiago Hors-Fraile, Octavio Rivera-Romero, Francine Schneider, Luis Fernandez-Luque, Francisco Luna-Perejon, Anton Civit-Balcells, Hein de Vries
BACKGROUND: Recommender systems are information retrieval systems that provide users with relevant items (e.g., through messages). Despite their extensive use in the e-commerce and leisure domains, their application in healthcare is still in its infancy. These systems may be used to create tailored health interventions, thus reducing the cost of healthcare and fostering a healthier lifestyle in the population. OBJECTIVE: This paper identifies, categorizes, and analyzes the existing knowledge in terms of the literature published over the past 10 years on the use of health recommender systems for patient interventions...
December 28, 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29330845/the-association-between-smoking-and-cancer-incidence-in-brca1-and-brca2-mutation-carriers
#6
Kwang-Pil Ko, Shana J Kim, Tomasz Huzarski, Jacek Gronwald, Jan Lubinski, Henry T Lynch, Susan Armel, Sue K Park, Beth Karlan, Christian F Singer, Susan L Neuhausen, Steven A Narod, Joanne Kotsopoulos
Tobacco smoke is an established carcinogen, but the association between tobacco smoking and cancer risk in BRCA mutation carriers is not clear. The aim of this study was to evaluate prospectively the association between tobacco smoking and cancer incidence in a cohort of BRCA1 and BRCA2 mutation carriers. The study population consisted of unaffected BRCA mutation carriers. Information on lifestyle including smoking histories, reproductive factors, and past medical histories was obtained through questionnaires...
January 13, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29330839/peripheral-blood-brain-derived-neurotrophic-factor-as-a-biomarker-of-alzheimer-s-disease-are-there-methodological-biases
#7
REVIEW
Marta Balietti, Cinzia Giuli, Fiorenzo Conti
Mounting evidence that alterations in brain-derived neurotrophic factor (BDNF) levels and signaling may be involved in the etiopathogenesis of Alzheimer's disease (AD) has suggested that its blood levels could be used as a biomarker of the disease. However, higher, lower, or unchanged circulating BDNF levels have all been described in AD patients compared to healthy controls. Although the reasons for such different findings are unclear, methodological issues are likely to be involved. The heterogeneity of participant recruitment criteria and the lack of control of variables that influence circulating BDNF levels regardless of dementia (depressive symptoms, medications, lifestyle, lack of overlap between serum and plasma, and experimental aspects) are likely to bias result and prevent study comparability...
January 13, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29330707/effects-of-periodontal-treatment-on-carotid-intima-media-thickness-in-patients-with-lifestyle-related-diseases-japanese-prospective-multicentre-observational-study
#8
Chieko Kudo, Wee Soo Shin, Nobuhiro Sasaki, Kazuo Harai, Kai Kato, Hiroaki Seino, Eiji Goke, Takemasa Fujino, Nobuichi Kuribayashi, Youko Onuki Pearce, Masato Taira, Ryoji Matsushima, Masato Minabe, Shogo Takashiba
Atherosclerosis, a chronic inflammatory disease in arterial blood vessels, is one of the major causes of death in worldwide. Meanwhile, periodontal disease is a chronic inflammatory disease caused by infection with periodontal pathogens such as P. gingivalis (Porphyromonas gingivalis). Several studies have reported association between periodontal infection and atherosclerosis, but direct investigation about the effects of periodontal treatment on atherosclerosis has not been reported. We have planned Japanese local clinics to determine the relationship between periodontal disease and atherosclerosis under collaborative with medical and dental care...
January 12, 2018: Odontology
https://www.readbyqxmd.com/read/29330695/glucosuria-and-all-cause-mortality-among-general-screening-participants
#9
Kunitoshi Iseki, Tsuneo Konta, Koichi Asahi, Kunihiro Yamagata, Shouichi Fujimoto, Kazuhiko Tsuruya, Ichiei Narita, Masato Kasahara, Yugo Shibagaki, Toshiki Moriyama, Masahide Kondo, Chiho Iseki, Tsuyoshi Watanabe
BACKGROUND: Dipstick urine tests are used for general health screening in Japan, but how the test results (e.g., glucosuria) relate to mortality is unknown. METHODS: Subjects participated in a nationwide screening in 2008 in six districts in Japan. We identified those who might have died using the national database of death certificates from 2008 to 2012 (total registered ~ 6 million) and verified candidates with the regional National Health Insurance Agency and public health nurses...
January 12, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29330694/volatile-compounds-from-beneficial-or-pathogenic-bacteria-differentially-regulate-root-exudation-transcription-of-iron-transporters-and-defense-signaling-pathways-in-sorghum-bicolor
#10
Erasto Hernández-Calderón, Maria Elizabeth Aviles-Garcia, Diana Yazmín Castulo-Rubio, Lourdes Macías-Rodríguez, Vicente Montejano Ramírez, Gustavo Santoyo, José López-Bucio, Eduardo Valencia-Cantero
Our results show that Sorghum bicolor is able to recognize bacteria through its volatile compounds and differentially respond to beneficial or pathogens via eliciting nutritional or defense adaptive traits. Plants establish beneficial, harmful, or neutral relationships with bacteria. Plant growth promoting rhizobacteria (PGPR) emit volatile compounds (VCs), which may act as molecular cues influencing plant development, nutrition, and/or defense. In this study, we compared the effects of VCs produced by bacteria with different lifestyles, including Arthrobacter agilis UMCV2, Bacillus methylotrophicus M4-96, Sinorhizobium meliloti 1021, the plant pathogen Pseudomonas aeruginosa PAO1, and the commensal rhizobacterium Bacillus sp...
January 12, 2018: Plant Molecular Biology
https://www.readbyqxmd.com/read/29330591/changes-in-the-lipopolysaccharide-of-proteus-mirabilis-9b-m-o11a-clinical-strain-in-response-to-planktonic-or-biofilm-type-of-growth
#11
Agnieszka Zabłotni, Dominik Matusiak, Nikolay P Arbatsky, Magdalena Moryl, Anna Maciejewska, Anna N Kondakova, Alexander S Shashkov, Czesław Ługowski, Yuriy A Knirel, Antoni Różalski
The impact of planktonic and biofilm lifestyles of the clinical isolate Proteus mirabilis 9B-m on its lipopolysaccharide (O-polysaccharide, core region, and lipid A) was evaluated. Proteus mirabilis bacteria are able to form biofilm and lipopolysaccharide is one of the factors involved in the biofilm formation. Lipopolysaccharide was isolated from planktonic and biofilm cells of the investigated strain and analyzed by SDS-PAGE with silver staining, Western blotting and ELISA, as well as NMR and matrix-assisted laser desorption ionization time-of-flight mass spectrometry techniques...
January 12, 2018: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/29330237/-the-hand-on-the-doorknob-visit-agenda-setting-by-complex-patients-and-their-primary-care-physicians
#12
Christine P Kowalski, Deanna B McQuillan, Neetu Chawla, Courtney Lyles, Andrea Altschuler, Connie S Uratsu, Elizabeth A Bayliss, Michele Heisler, Richard W Grant
BACKGROUND: Choosing which issues to discuss in the limited time available during primary care visits is an important task for complex patients with chronic conditions. DESIGN, SETTING, AND PARTICIPANTS: We conducted sequential interviews with complex patients (n = 40) and their primary care physicians (n = 17) from 3 different health systems to investigate how patients and physicians prepare for visits, how visit agendas are determined, and how discussion priorities are established during time-limited visits...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29330101/telephone-based-weight-loss-support-for-patients-with-knee-osteoarthritis-a-pragmatic-randomized-controlled-trial
#13
Kate M O'Brien, John Wiggers, Amanda Williams, Elizabeth Campbell, Rebecca K Hodder, Luke Wolfenden, Sze Lin Yoong, Emma K Robson, Robin Haskins, Steven J Kamper, Chris Rissel, Christopher M Williams
OBJECTIVE: To determine the effectiveness of telephone-based weight loss support in reducing the intensity of knee pain in patients with knee osteoarthritis, who are overweight or obese, compared to usual care. DESIGN: We conducted a parallel randomized controlled trial (RCT), embedded within a cohort multiple RCT of patients on a waiting list for outpatient orthopaedic consultation at a tertiary referral hospital in NSW, Australia. Patients with knee osteoarthritis, classified as overweight or obese (body mass index between ≥27kg/m2 and <40kg/m2) were randomly allocated to receive referral to an existing non-disease specific government funded 6-month telephone-based weight management and healthy lifestyle service or usual care...
January 9, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29330029/association-of-100-fruit-juice-consumption-and-3-year-weight-change-among-postmenopausal-women-in-the-in-the-women-s-health-initiative
#14
Brandon J Auerbach, Alyson J Littman, James Krieger, Bessie A Young, Joseph Larson, Lesley Tinker, Marian L Neuhouser
The association between drinking 100% fruit juice and long-term weight gain is controversial and has been investigated in few studies. We examined whether 100% fruit juice consumption was associated with weight change in a large prospective cohort of postmenopausal women. We analyzed data from 49,106 postmenopausal women in the United States enrolled in the Women's Health Initiative between 1993 and 1998. Food frequency questionnaires at baseline and year 3 assessed food and beverage intake. Body weight was measured at in-person clinic visits...
January 9, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29330002/choosing-a-healthy-and-sustainable-diet-a-three-level-approach-for-understanding-the-drivers-of-the-italians-dietary-regime-over-time
#15
Ilaria Benedetti, Tiziana Laureti, Luca Secondi
Dietary patterns play key roles in health promotion and in preserving the environment. A growing number of studies show the importance of individual factors on food consumption choices, such as socio-economic status, lifestyle variables and contextual and social factors that characterize the geographical area in which individuals reside. The Mediterranean Diet is a sustainable diet that respects the environment, thus reducing per capita emissions from food production in respect to less sustainable diet. The aim of this paper is to determine the Italians' prevailing food patterns using a composite indicator and to identify which factors determine a higher adherence to the Mediterranean Diet in Italy...
January 9, 2018: Appetite
https://www.readbyqxmd.com/read/29329975/risk-of-suicide-and-non-fatal-self-harm-after-bariatric-surgery-results-from-two-matched-cohort-studies
#16
Martin Neovius, Gustaf Bruze, Peter Jacobson, Kajsa Sjöholm, Kari Johansson, Fredrik Granath, Johan Sundström, Ingmar Näslund, Claude Marcus, Johan Ottosson, Markku Peltonen, Lena M S Carlsson
BACKGROUND: Bariatric surgery reduces mortality, but might have adverse effects on mental health. We assessed the risk of suicide and self-harm after bariatric surgery compared with non-surgical obesity treatment. METHODS: Suicide and non-fatal self-harm events retrieved from nationwide Swedish registers were examined in two cohorts. The non-randomised, prospective Swedish Obese Subjects (SOS) study compared bariatric surgery (n=2010; 1369 vertical-banded gastroplasty, 376 gastric banding, and 265 gastric bypass) with usual care (n=2037; recruitment 1987-2001)...
January 9, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29329898/-prognostic-of-older-age-for-patients-with-invasive-muscle-bladder-cancer-and-treated-by-radical-cystectomy
#17
Y Dehayni, M Tetou, Y Khdach, A Janane, M Alami, A Ameur
INTRODUCTION: Bladder tumor is a disease of older persons, but can also occur in young adults, because certainly an influence of environmental factors and a change of lifestyle. The aim of our retrospective analysis is to assess and evaluate the extent of the prognostic impact of age on the carcinological prognosis of invasive-muscle-bladder cancer treated by total cystotomy. METHODS: To evaluate the association of patient age with pathological characteristics and recurrence-free and disease survival, we retrospectively reviewed 345 patients with invasive bladder cancer between January 2000 and January 2015...
January 9, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29329572/socio-demographic-and-lifestyle-determinants-of-dietary-patterns-in-french-speaking-switzerland-2009-2012
#18
Pedro Marques-Vidal, Gérard Waeber, Peter Vollenweider, Idris Guessous
BACKGROUND: Food intake is a complex behaviour which can be assessed using dietary patterns. Our aim was to characterize dietary patterns and associated factors in French-speaking Switzerland. METHODS: Cross-sectional study conducted between 2009 and 2012 in the city of Lausanne, Switzerland, including 4372 participants (54% women, 57.3 ± 10.3 years). Food consumption was assessed using a validated food frequency questionnaire. Dietary patterns were assessed by principal components analysis...
January 12, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29329063/seasonality-of-depressive-symptoms-in-women-but-not-in-men-a-cross-sectional-study-in-the-uk-biobank-cohort
#19
Laura M Lyall, Cathy A Wyse, Carlos A Celis-Morales, Donald M Lyall, Breda Cullen, Daniel Mackay, Joey Ward, Nicholas Graham, Rona J Strawbridge, Jason M R Gill, Amy Ferguson, Mark E S Bailey, Jill P Pell, Annie M Curtis, Daniel J Smith
BACKGROUND: We examined whether seasonal variations in depressive symptoms occurred independently of demographic and lifestyle factors, and were related to change in day length and/or outdoor temperature. METHODS: In a cross-sectional analysis of >150,000 participants of the UK Biobank cohort, we used the cosinor method to assess evidence of seasonality of a total depressive symptoms score and of low mood, anhedonia, tenseness and tiredness scores in women and men...
January 4, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29329059/amyloid-burden-and-incident-depressive-symptoms-in-preclinical-alzheimer-s-disease
#20
Stephanie Perin, Karra D Harrington, Yen Ying Lim, Kathryn Ellis, David Ames, Robert H Pietrzak, Adrian Schembri, Stephanie Rainey-Smith, Olivier Salvado, Simon M Laws, Ralph N Martins, Victor L Villemagne, Christopher C Rowe, Colin L Masters, Paul Maruff
BACKGROUND: Relationships between depression and Alzheimer's disease (AD) may become clearer if studied in preclinical AD where dementia is not present. METHOD: The aim of this study was to evaluate prospectively, relationships between brain amyloid-β (Aβ), depressive symptoms and screen positive depression in cognitively normal (CN) older adults. Depressive symptoms were measured with the Geriatric Depression Inventory (GDS-15) in CN adults from the Australian Imaging Biomarkers and Lifestyle (AIBL) study without depression at baseline and classified as having abnormally high (Aβ+; n = 136) or low (Aβ-; n = 449) Aβ according to positron emission tomography at 18-month intervals over 72 months...
January 3, 2018: Journal of Affective Disorders
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