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Mitral valve disease

Shahbaz Ali Malik, Samer Sayyed, Gregory Pavlides
The image presented is a still frame taken from a transesophageal echocardiogram of a 76-year-old male who was referred for evaluation of mitral valve disease. He was found to have a non-flow limiting membrane, dividing the left atrium into two sections, consistent with the diagnosis of cor triatriatum sinister.
May 2018: South Dakota Medicine: the Journal of the South Dakota State Medical Association
Jin-Tao Fu, Mohammad Sharif Popal, Yu-Qing Jiao, Hai-Bo Zhang, Shuai Zheng, Qiu-Ming Hu, Wei Han, Xu Meng
Background: Mobility and flexibility of anterior mitral leaflet (AML) are considered to be the important factor for mitral valve (MV) repair in rheumatic population, we try to use the bending angle of AML to quantify its' mobility and flexibility and investigate whether it can predict the success of rheumatic MV repair or not. Methods: Total 54 patients underwent rheumatic MV surgeries with mild lesions of subvalvular apparatus from August, 2017 to November, 2017 at the author institution, we divided the patients into MV repair and MV replacement groups which included directly MV replacement and repair attempt but failed repairing transfer to replacement intraoperatively...
May 2018: Journal of Thoracic Disease
Meng-Lin Lee, Thay-Hsiung Chen, Hsien-Da Huang, Shaw-Min Hou
Background: The optimal management of ischemic mitral regurgitation (IMR) is controversial. The aim of this study was to examine our eight years' experience of surgical treatment in patients with IMR, and to compare outcomes of mitral valve repair versus replacement with concomitant coronary artery bypass grafting (CABG). Methods: A retrospective, observational, cohort study was undertaken to collect data on consecutive patients with IMR and coronary artery disease who received CABG and mitral valve surgery in our hospital between January 2008 and December 2015...
May 2018: Journal of Thoracic Disease
Malik Saad Sultan, Nelson Costa Martins, Eva Costa, Diana Veiga, Manuel Joao Ferreira, Sandra Mattos, Miguel Tavares Coimbra
Rheumatic heart disease can result from repeated episodes of acute rheumatic fever, which damages the heart valves and reduces their functionality. Early manifestations of heart valve damage are visible in echocardiography in the form of valve thickening, shape changing and mobility reduction. The quantification of these features is important for a precise diagnosis and it is the main motivation for this work. The first step to make this quantification is to accurately identify and track the anterior mitral leaflet throughout the cardiac cycle...
January 30, 2018: IEEE Journal of Biomedical and Health Informatics
Marcell J Tjørnild, Søren N Skov, Diana M Røpcke, Christine Ilkjær, Jonas Rasmussen, Jean-Paul Couetil, Sten L Nielsen
OBJECTIVES: To develop and evaluate a novel mitral annuloplasty ring with selective flexibility for septal-lateral contraction and rigidity for septal-lateral dilatation in an acute porcine model. METHODS: The novel mitral annuloplasty ring was designed with slits in the luminal posterior segment and annular lateral segments. The slits were designed to allow inward motion during contraction and to block outward motion during dilation. The novel mitral annuloplasty ring was tested in vitro with a dedicated mechanical test bench, followed by in vivo characterization, using sonomicrometry and echocardiography for annular and leaflet geometry, in an acute porcine model...
July 9, 2018: Interactive Cardiovascular and Thoracic Surgery
Shin Watanabe, Olympia Bikou, Roger J Hajjar, Kiyotake Ishikawa
Mitral regurgitation (MR) is among the most common valvular heart diseases in clinics. MR induces volume overload of the heart and leads to heart failure (HF). Because physiological and molecular mechanisms in nonischemic HF are distinct from that of ischemic HF, a clinically relevant animal model of nonischemic HF is important for understanding the pathophysiology and developing new therapeutics targeting this HF phenotype. Additionally, the large animal model of MR provides opportunities to test new surgical and percutaneous approaches for correcting mitral valve insufficiency...
2018: Methods in Molecular Biology
Dae-Hee Kim, Brittan Morris, J Luis Guerrero, Suzanne M Sullivan, Judy Hung, Robert A Levine
Ischemic mitral regurgitation (IMR) is a common complication of ischemic heart disease that doubles mortality after myocardial infarction and is a major driving factor increasing heart failure. IMR is caused by left ventricular (LV) remodeling which displaces the papillary muscles that tether the mitral valve leaflets and restrict their closure. IMR frequently recurs even after surgical treatment. Failed repair associates with lack of reduction or increase in LV remodeling, and increased heart failure and related readmissions...
2018: Methods in Molecular Biology
Lisette J M E van der Does, Frans B S Oei, Paul Knops, Ad J J C Bogers, Natasja M S de Groot
Mapping of the unorganized activation patterns of atrial fibrillation requires a high-resolution mapping approach to diagnose substrate-mediated pathophysiological mechanisms. At present, epicardial mapping is the only approach that is able to acquire electrograms of >200 high-density sites simultaneously. This study introduces a technique to perform high-resolution mapping in minimally invasive surgery. In 3 patients with mitral valve disease, epicardial mapping of the right atrium, Bachmann's bundle and parts of the left atrium was safely performed via minimal right thoracotomy...
July 6, 2018: Interactive Cardiovascular and Thoracic Surgery
Gregory Y H Lip, Martin Jensen, Line Melgaard, Flemming Skjøth, Peter Brønnum Nielsen, Torben Bjerregaard Larsen
Aims: Substantial interest has been directed towards stroke risk stratification in patients with atrial fibrillation (AF) but prior studies have focused on AF without significant valvular heart disease (VHD), so-called 'non-valvular AF'. A formal validation exercise addressing stroke risks in relation to the CHA2DS2-VASc risk factor(s) in AF patients with VHD is lacking. Also, the use of the HAS-BLED score in anticoagulated patients with VHD has not been previously studied. The aim of this study was to investigate stroke and bleeding rates in AF patients with VHD in relation to the CHA2DS2-VASc and HAS-BLED scores...
July 6, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Sonia A El-Saiedi, Hala M Agha, Mohamed F Shaltoot, Hayat H Nassar, Amal M El Sisi, Wael A Attia, Yasser M Sedky
Objective: Real-time three-dimensional echocardiography, using both reconstruction methods and RT3D, has been used as an extra helping tool in several forms of congenital heart diseases. Our aim was to understand the relation of the ASD device to all surrounding structures by 3-dimensional echocardiography (3D). Methods: This prospective study included 37 patients diagnosed as ASD secundum by transthoracic (TTE) and transesophageal echocardiography (TEE) referred for transcatheter closure from October 2013 to July 2016...
July 2018: Journal of the Saudi Heart Association
Tiffany Chen, Victor A Ferrari, Frank E Silvestry
Chronic mitral regurgitation (MR), whether due to valve degeneration or secondary to myocardial disease, affects an increasing proportion of the aging population. Percutaneous mitral valve interventions, including edge-to-edge repair, are emerging as feasible and effective therapy for patients with severe MR at high or prohibitive surgical risk. Imaging with echocardiography is crucial for patient selection by evaluating mitral anatomy, the mechanism of dysfunction, and MR severity. In this article, the authors review the imaging characteristics for identifying and quantifying degenerative and functional MR for transcatheter mitral valve repair...
July 2018: Interventional cardiology clinics
Begum Uygur, Omer Celik, Fethi Emre Ustabasioglu, Okan Akinci, Mehmet Erturk
AIM: Rheumatic heart disease is a common cause of valvular disease, especially in developing countries. Echocardiography is the gold standard investigation modality for cardiac valves. In rheumatic mitral stenosis (MS), three-dimensional transesophageal echocardiography (3D TEE) provides better alignment of the image plane at the mitral tips and more accurate and reproducible planimetric measurement of mitral valve area (MVA). Cardiac magnetic resonance (CMR) is a new method that provides evaluation of cardiac anatomy and function noninvasively...
July 7, 2018: Echocardiography
James J Miller, Kazuhiro Aoki, Carly A Mascari, Angela K Beltrame, Olayemi Sokumbi, Paula E North, Michael Tiemeyer, Alison J Kriegel, Nancy M Dahms
Fabry disease is an X-linked lysosomal storage disease caused by α-galactosidase A (α-Gal A) deficiency. Kidney and heart failure are frequent complications in adulthood and greatly contribute to patient morbidity and mortality. Because α-Gal A-deficient mouse models do not recapitulate cardiorenal findings observed in patients, a nonmouse model may be beneficial to our understanding of disease pathogenesis. In this study, we evaluated disease processes in a recently generated Fabry rat model. We found that male Fabry rats weighed significantly less than wild-type (WT) males, whereas female Fabry rats weighed significantly more than WT females...
July 6, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Magdalena Garncarz, Marta Parzeniecka-Jaworska, Magdalena Hulanicka, Michał Jank, Olga Szaluś-Jordanow, Anna Kurek
Introduction: Older small breed dogs are considered at risk for heart failure secondary to chronic mitral valve disease. However, few data are available on the onset of this disease in such dogs. This study was performed to determine if auscultation alone can be used to eliminate clinically relevant mitral valve regurgitation seen in echocardiography in Dachshund dogs. Material and Methods: Clinical and echocardiographic data were obtained from 107 dogs without heart murmurs...
September 2017: Journal of veterinary research
Sophie Korzan, Evan Jones, Rahul Mutneja, Prashant Grover
Severe mitral valve stenosis caused by rheumatic heart disease presenting initially as massive hemoptysis has become a rare occurrence in contemporary western medicine. Massive hemoptysis can be due to multiple disease processes including airway diseases such as bronchiectasis, pulmonary parenchymal disease of infectious or autoimmune etiology, pulmonary AVM's, hematologic disorders, and numerous drugs and iatrogenic injuries. It is less associated with congestion from rheumatic heart disease due to the earlier detection and subsequent management of cardiac valve disease preventing the sequela of more severe disease...
2018: Respiratory Medicine Case Reports
Inna Kaminecki, Renuka Verma, Jacqueline Brunetto, Loyda I Rivera
While the incidence of acute rheumatic fever (ARF) in the United States has declined over the past years, the disease remains one of the causes of severe cardiovascular morbidity in children. The index of suspicion for ARF in health care providers may be low due to decreasing incidence of the disease and clinical presentation that can mimic other conditions. We present the case of a 5-year-old boy with a history of intermittent fevers, fatigue, migratory joint pain, and weight loss following group A Streptococcus pharyngitis...
2018: Case Reports in Pediatrics
Seyyed-Reza Sadat-Ebrahimi, Neda Parnianfard, Nafiseh Vahed, Hossein Babaei, Morteza Ghojazadeh, Sydney Tang, Amir Azarpazhooh
PURPOSE: Lisinopril is one of the angiotensin-converting-enzyme inhibitors that is largely being administered for its off-label uses. This study aims to provide a comprehensive review of off-label uses of lisinopril to aid physicians to make evidence-based decisions. METHODS: The following bibliographic databases were searched from inception until 30 March 2017: PubMed, EMBASE, the Cochrane Library, Cochrane Central Register of Controlled Trials, Scopus, Ovid, and Proquest...
July 3, 2018: British Journal of Clinical Pharmacology
Mahmut Yesin, Süleyman Karakoyun, Macit Kalçık, Mustafa Ozan Gürsoy, Sabahattin Gündüz, Mehmet Ali Astarcıoğlu, Emrah Bayam, Sinan Cerşit, Ahmet Güner, Mehmet Özkan
Coronary thromboembolism (CE) is a rare cause of prosthetic valve derived complications. This study investigates the diagnosis and treatment strategies for non-ST elevation acute coronary syndrome (NSTEACS) in patients with prosthetic heart valves. Forty-eight NSTEACS patients with prosthetic heart valves (mitral:27; aortic:14; mitral+aortic:7) were included in this study. All patients underwent transthoracic and transesophageal echocardiographic examination and coronary angiography. Normal coronary angiographic findings, or visible trombus in one of the coronary arteries, international normalized ratio <2, concomitant prosthetic valve thrombosis (PVT) and absence of multivessel atherosclerotic disease favored CE rather than atherothrombosis...
May 11, 2018: American Journal of Cardiology
Sherri Schwaninger, John Musuku, Mark E Engel, Patrick Musonda, Joyce Chipili Lungu, Elizabeth Machila, Agnes Mtaja, Evans Mulendele, Dorothy Kavindele, Jonathan Spector, Brigitta Tadmor, Marcelo M Gutierrez, Joris Van Dam, Laurence Colin, Aidan Long, Mark C Fishman, Bongani M Mayosi, Liesl J Zühlke
BACKGROUND: The large global burden of rheumatic heart disease (RHD) has come to light in recent years following robust epidemiologic studies. As an operational research component of a broad program aimed at primary and secondary prevention of RHD, we sought to determine the current prevalence of RHD in the country's capital, Lusaka, using a modern imaging-based screening methodology. In addition, we wished to evaluate the practicality of training local radiographers in echocardiography screening methods...
July 3, 2018: BMC Cardiovascular Disorders
Damiano Regazzoli, Antonio Mangieri, Ozan Demir, Marco B Ancona, Giuseppe Lanzillo, Francesco Giannini, Pier P Leone, Antonio Colombo, Azeem Latib
Tricuspid valve regurgitation has a high prevalence and, when severe, is associated with poor outcomes. Nevertheless, surgical repair or replacement (isolated or as a part of a combined procedure) is rarely performed due to high surgical risk. Therefore, there is a significant unmet clinical need for percutaneous transcatheter-based treatments. Significant development in percutaneous therapies for both aortic and mitral valve disease has been accomplished over the last two decades, while transcatheter therapies for the tricuspid valve are still at an early stage...
June 29, 2018: Minerva Cardioangiologica
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