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https://www.readbyqxmd.com/read/27898687/effects-of-chronologic-age-and-young-child-exposure-on-respiratory-syncytial-virus-disease-among-us-preterm-infants-born-at-32-to-35-weeks-gestation
#1
Eric A F Simões, Evan J Anderson, Xionghua Wu, Christopher S Ambrose
OBJECTIVE: To estimate the incidence of respiratory syncytial virus (RSV) disease as a function of chronologic age and exposure to young children in US preterm infants. METHODS: In the RSV Respiratory Events among Preterm Infants Outcomes and Risk Tracking (REPORT) study, preterm infants born at 32-35 weeks gestational age (wGA) were enrolled from 188 US clinics and followed September-May of 2009-2010 or 2010-2011. Infants with medically-attended acute respiratory illness had nasal/pharyngeal swabs collected for viral testing...
2016: PloS One
https://www.readbyqxmd.com/read/27893060/association-between-allergen-exposure-in-inner-city-schools-and-asthma-morbidity-among-students
#2
William J Sheehan, Perdita Permaul, Carter R Petty, Brent A Coull, Sachin N Baxi, Jonathan M Gaffin, Peggy S Lai, Diane R Gold, Wanda Phipatanakul
Importance: Home aeroallergen exposure is associated with increased asthma morbidity in children, yet little is known about the contribution of school aeroallergen exposures to such morbidity. Objective: To evaluate the effect of school-specific aeroallergen exposures on asthma morbidity among students, adjusting for home exposures. Design, Setting, and Participants: The School Inner-City Asthma Study was a prospective cohort study evaluating 284 students aged 4 to 13 years with asthma who were enrolled from 37 inner-city elementary schools in the northeastern United States between March 1, 2008, and August 31, 2013...
November 21, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27888993/identifying-biomarkers-for-asthma-diagnosis-using-targeted-metabolomics-approaches
#3
William Checkley, Maria P Deza, Jost Klawitter, Karina M Romero, Jelena Klawitter, Suzanne L Pollard, Robert A Wise, Uwe Christians, Nadia N Hansel
BACKGROUND: The diagnosis of asthma in children is challenging and relies on a combination of clinical factors and biomarkers including methacholine challenge, lung function, bronchodilator responsiveness, and presence of airway inflammation. No single test is diagnostic. We sought to identify a pattern of inflammatory biomarkers that was unique to asthma using a targeted metabolomics approach combined with data science methods. METHODS: We conducted a nested case-control study of 100 children living in a peri-urban community in Lima, Peru...
December 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27888986/relationship-between-birth-weight-maternal-smoking-during-pregnancy-and-childhood-and-adolescent-lung-function-a-path-analysis
#4
Pallavi Balte, Wilfried Karmaus, Graham Roberts, Ramesh Kurukulaaratchy, Frances Mitchell, Hasan Arshad
BACKGROUND: Low birth weight and gestational maternal smoking have been linked with reduced lung function in children in many cross sectional studies. However, these associations have not yet been assessed with repeated measurements of lung function. Our aim was to investigate the effects of birth weight, gestational age, and gestational maternal smoking on lung function in children at age 10 and 18 years. METHODS: In the Isle of Wight birth cohort spirometry was performed at age 10 and 18 years...
December 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27884144/assessment-of-serology-and-spirometry-and-the-combination-of-both-to-complement-microbiological-isolation-for-earlier-detection-of-pseudomonas-aeruginosa-infection-in-children-with-cystic-fibrosis
#5
Ana Kotnik Pirš, Uroš Krivec, Saša Simčič, Katja Seme
BACKGROUND: The aim of this study was to assess whether serology and spirometry and the combination of both can complement culture-based detection for earlier recognition of Pseudomonas aeruginosa infection in children with cystic fibrosis. METHODS: A 4 year longitudinal prospective study that included 67 Slovenian children with cystic fibrosis with a mean age of 10.5 years was conducted. Serology, spirometry and a scoring system combining serology and spirometry were assessed and compared...
November 25, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27873442/forced-deflation-pulmonary-function-test-a-novel-method-to-evaluate-lung-function-in-infants-and-young-children
#6
Rakesh K Goyal, Azada Ibrahimova, Maria L Escolar, Paul Szabolcs, Mark Vander Lugt, Randy M Windreich, Daniel J Weiner
We describe the safety and feasibility of a forced deflation pulmonary function test (dPFT) in infants and young children. Fifty-two dPFT studies were performed in 26 patients (median age, 1.4 years). Forced vital capacity (FVC) and forced expiratory flow (FEF75 ) were normal in all except one case, but respiratory system compliance (Crs) was reduced in 24% patients. There were no significant differences in pre-blood and marrow transplantation FVC, FEF75 , and Crs between those patients who did and those who did not have posttransplant pulmonary complications...
November 22, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27873431/hypoglycemia-is-common-in-children-with-cystic-fibrosis-and-seen-predominantly-in-females
#7
Belma Haliloglu, Yasemin Gokdemir, Zeynep Atay, Saygin Abali, Tulay Guran, Fazilet Karakoc, Refika Ersu, Bulent Karadag, Serap Turan, Abdullah Bereket
OBJECTIVE: To determine the prevalence of hypoglycemia in children and adolescents with cystic fibrosis (CF) in 2-hour oral glucose tolerance test (OGTT) and continuous glucose monitoring (CGM) under free-living conditions. RESEARCH DESIGN AND METHODS: Height, weight, body mass index (BMI), hemoglobin A1c (HbA1c), and Forced expiratory volume (FEV1%) were measured in children with CF (aged 5-18 years). Following OGTT, CGM was installed for 3 days. The total hypoglycemic and hyperglycemic time (%) during 3 days was measured...
November 22, 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/27872847/strengths-pitfalls-and-lessons-from-longitudinal-childhood-asthma-cohorts-of-children-followed-up-into-adult-life
#8
REVIEW
Andrew Tai
Asthma is a common problem worldwide and longitudinal studies of children followed up into adult life enable the assessment of clinical outcomes, examine the pattern of lung function outcomes, and importantly provide insight into aetiology and prognosis for patients with asthma. The aim of this review is to examine the major childhood asthma cohort studies which have continued into adult life, describing the strengths and weaknesses and the lessons that can be learnt regarding pathophysiology and potential future directions for research...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27870589/results-of-a-prospective-study-evaluating-a-non-invasive-method-of-hemoglobin-adjustment-for-determining-the-diffusing-capacity-of-the-lung
#9
Karla E Foster, Rashmi D Sahay, Nanhua Zhang, William D Hardie
RATIONALE: Measurement of the lung diffusing capacity for carbon monoxide (DLCO) is significantly influenced by the pulmonary capillary blood volume. Consequently, measurements require adjustment for blood hemoglobin concentration (DLCOADJ) to allow meaningful clinical interpretation. Noninvasive point-of-care devices that measure hemoglobin transcutaneously provide immediate values for hemoglobin that may be useful in pulmonary function laboratories for determining DLCOADJ. OBJECTIVES: To test the hypothesis that DLCOADJ determinations obtained using a commerciallyavailable device for noninvasive, point-of-care measurement of blood hemoglobin concentrations are not importantly different from determinations obtained using hemoglobin concentrations measured conventionally on venous blood samples...
November 21, 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27869239/polish-mother-and-child-cohort-study-repro_pl-methodology-of-the-follow-up-of-the-children-at-the-age-of-7
#10
REVIEW
Kinga Polańska, Wojciech Hanke, Anna Król, Adrianna Potocka, Małgorzata Waszkowska, Aleksandra Jacukowicz, Jolanta Gromadzińska, Wojciech Wąsowicz, Joanna Jerzyńska, Włodzimierz Stelmach, Iwona Stelmach
Effects of environmental exposures in utero and in the first years of life on early life health and development is a growing research area with major public health implications. The main aim of this work has been to provide an overview of the next step of the Polish Mother and Child Cohort Study (REPRO_PL) covering exposure, health and neurodevelopment assessments of children at 7 years of age. Details regarding methodology of the follow-up of the children are crucial for cross-cohort collaboration and a full understanding of the future research questions...
November 18, 2016: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/27859825/do-children-with-cystic-fibrosis-receiving-outreach-care-have-poorer-clinical-outcomes-than-those-treated-at-a-specialist-cystic-fibrosis-centre
#11
Heinrich C Weber, Philip F Robinson, Nicole Saxby, Sean A Beggs, Ingrid Els, Rodney I Ehrlich
INTRODUCTION: Although cystic fibrosis (CF) centre care is generally considered ideal, children living in regional Australia receive outreach care supported by the academic CF centres. METHODS: This is a retrospective database review of children with CF treated at the Royal Children's Hospital in Melbourne and its outreach clinics in Albury (Victoria), and Tasmania. The aim was to compare the outcomes of children with CF managed at an academic centre with that of outreach care, using lung function, nutritional status and Pseudomonas aeruginosa colonisation...
November 17, 2016: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/27856821/determinants-of-early-life-lung-function-in-african-infants
#12
Diane Gray, Lauren Willemse, Ane Visagie, Dorottya Czövek, Polite Nduru, Aneesa Vanker, Dan J Stein, Nastassja Koen, Peter D Sly, Zoltán Hantos, Graham L Hall, Heather J Zar
BACKGROUND: Low lung function in early life is associated with later respiratory illness. There is limited data on lung function in African infants despite a high prevalence of respiratory disease. AIM: To assess the determinants of early lung function in African infants. METHOD: Infants enrolled in a South African birth cohort, the Drakenstein child health study, had lung function measured at 6-10 weeks of age. Measurements, made with the infant breathing via a facemask during natural sleep, included tidal breathing, sulfur hexafluoride multiple breath washout and the forced oscillation technique...
November 17, 2016: Thorax
https://www.readbyqxmd.com/read/27854286/-english-disease-historical-notes-on-rickets-the-bone-lung-link-and-child-neglect-issues
#13
REVIEW
Mingyong Zhang, Fan Shen, Anna Petryk, Jingfeng Tang, Xingzhen Chen, Consolato Sergi
Nutritional or classical rickets (here labeled as "rickets") is a worldwide disease involving mostly infants and young children having inadequate sunlight exposure, often associated with a low dietary intake of Vitamin D. Rickets targets all layers of society independently of economic status with historical information spanning more than two millennia. Vitamin D is critical for the absorption of calcium and prevention of rickets in children as well as osteomalacia in adults. The initial and misleading paradigm of the 19th and 20th centuries that rickets may have been the consequence of infection has been, indeed, reversed following the identification of the Vitamin D molecule's important role in the function of the immune system...
November 15, 2016: Nutrients
https://www.readbyqxmd.com/read/27849230/primary-hypogammaglobulinemia-the-impact-of-early-diagnosis-in-lung-complications
#14
Mayra de Barros Dorna, Cristiane de Jesus Nunes Dos Santos, Ana Paula Beltran Moschione Castro, Luiz Antônio Nunes de Oliveira, Lisa Suzuki, Andrea Langone Ferme, Magda Maria Sales Carneiro-Sampaio, Antonio Carlos Pastorino
Objective: To describe clinical features, tomographic findings and pulmonary function in pediatric patients with primary hypogammaglobulinemia (PH). Method: A retrospective cohort study of children with PH who received intravenous immunoglobulin (IVIG) and prophylactic antibiotics between 2005 and 2010. Epidemiological and clinical features, computed tomography (CT) findings, and spirometric data were compared, assuming a 5% significance level. Results: We evaluated 30 patients with PH...
September 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/27848934/considering-spatial-heterogeneity-in-the-distributed-lag-non-linear-model-when-analyzing-spatiotemporal-data
#15
Lung-Chang Chien, Yuming Guo, Xiao Li, Hwa-Lung Yu
The distributed lag non-linear (DLNM) model has been frequently used in time series environmental health research. However, its functionality for assessing spatial heterogeneity is still restricted, especially in analyzing spatiotemporal data. This study proposed a solution to take a spatial function into account in the DLNM, and compared the influence with and without considering spatial heterogeneity in a case study. This research applied the DLNM to investigate non-linear lag effect up to 7 days in a case study about the spatiotemporal impact of fine particulate matter (PM2...
November 16, 2016: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/27834336/evaluation-of-symptoms-spirometry-in-children-treated-for-asthma
#16
Shobi Anandi, Milind S Tullu, Keya Lahiri
BACKGROUND & OBJECTIVES: Spirometry plays an important role in the assessment and long term monitoring of patients with asthma. Difficulty in performing spirometry in children has resulted in a paucity of Indian studies using spirometry regularly for research in the paediatric population. This study was undertaken to assess the clinical improvement and changes in spirometric measurements with treatment in children with newly diagnosed asthma and to compare the changes in the symptom score and spirometric measurements...
July 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27831801/high-success-rate-of-lung-function-testing-in-healthy-unsedated-1-and-2-year-old-south-african-children
#17
Lauren Willemse, Ane Visagie, Carvern Denver Jacobs, Heather J Zar, Graham L Hall, Diane M Gray
No abstract text is available yet for this article.
November 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27825189/exhaled-nitric-oxide-levels-to-guide-treatment-for-children-with-asthma
#18
REVIEW
Helen L Petsky, Kayleigh M Kew, Anne B Chang
BACKGROUND: Asthma guidelines aim to guide health practitioners to optimise treatment for patients to minimise symptoms, improve or maintain good lung function, and prevent acute exacerbations. The principle of asthma guidelines is based on a step-up or step-down regimen of asthma medications to maximise health using minimum doses. Fractional exhaled nitric oxide (FeNO) is a marker of eosinophilic inflammation and tailoring asthma medications in accordance to airway eosinophilic levels may improve asthma outcomes such as indices of control or reduce exacerbations, or both...
November 9, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27810156/pulmonary-arterial-capacitance-index-is-a-strong-predictor-for-adverse-outcome-in-children-with-idiopathic-and-heritable-pulmonary-arterial-hypertension
#19
Shinichi Takatsuki, Tomotaka Nakayama, Satoshi Ikehara, Hiroyuki Matsuura, David Dunbar Ivy, Tsutomu Saji
OBJECTIVES: To evaluate the clinical utility of pulmonary artery capacitance index (PACi) in the assessment of disease severity and prognostic value in children with idiopathic and heritable pulmonary arterial hypertension (PAH). STUDY DESIGN: PACi is defined as the ratio of stroke volume index over pulmonary pulse pressure. A retrospective study was performed to compare PACi, brain natriuretic peptide (BNP), 6-minute walk distance, New York Heart association (NYHA) functional class, and adverse outcomes (hospitalization due to heart failure, lung transplantation, and cardiac mortality) in 72 Japanese children (10 ± 3...
October 31, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27801711/diagnostic-challenges-of-childhood-asthma
#20
Arzu Bakirtas
PURPOSE OF REVIEW: Diagnosis of asthma in childhood is challenging. Both underdiagnosis and overdiagnosis of asthma are important issues. The present review gives information about challenging factors for an accurate diagnosis of childhood asthma. RECENT FINDINGS: Although underdiagnosis of asthma in childhood has always been the most important diagnostic problem, overdiagnosis of asthma has also been increasingly recognized. This is probably due to diagnosis of asthma based on symptoms and signs alone...
January 2017: Current Opinion in Pulmonary Medicine
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