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https://www.readbyqxmd.com/read/28913990/association-between-sensitization-to-mold-and-impaired-pulmonary-function-in-children-with-asthma
#1
Jung Hye Byeon, Soohyun Ri, Oyuntulga Amarsaikhan, Eunji Kim, So Hyun Ahn, Ic Sun Choi, Hyung Jin Kim, SungChul Seo, Wonsuck Yoon, Young Yoo
PURPOSE: Recent data indicate that sensitization to mold contributes to the severity and persistence of asthma. In this study, we investigated the relationships between sensitization to mold and lung function parameters in children with asthma. METHODS: We retrospectively reviewed clinical data from 551 asthmatic subjects. We selected subjects who met clinical diagnostic criteria of asthma. Their spirometry, methacholine challenge tests, and measurements of blood eosinophils, serum IgE, eosinophil cationic protein (ECP) and fractional exhaled nitric oxide (FeNO) results were included...
November 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28904266/clinical-impact-of-main-pulmonary-artery-dilatation-on-outcome-in-pediatric-idiopathic-and-heritable-pulmonary-arterial-hypertension
#2
Satoshi Ikehara, Shinichi Takatsuki, Tomotaka Nakayama, Kazuyuki Naoi, Hiroyuki Matsuura, Tsutomu Saji
BACKGROUND: Few studies have investigated the clinical impact of pulmonary artery (PA) dilatation on outcomes in pediatric pulmonary arterial hypertension (PAH).Methods and Results:This study investigated the clinical outcomes of idiopathic or heritable PAH in 66 children aged <18 years at diagnosis. Main PA/thorax (MPA/T) ratio was measured on chest radiography in PAH patients. Patients were divided into 2 groups based on MPA/T ratio, and compared with a control group of 166 age- and gender-matched healthy children...
September 13, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28887056/quantification-of-volume-and-lipid-filling-of-intracellular-vesicles-carrying-the-abca3-transporter
#3
Stefanie Höppner, Susanna Kinting, Adriano A Torrano, Ulrike Schindlbeck, Christoph Bräuchle, Ralf Zarbock, Thomas Wittman, Matthias Griese
The ABCA3 lipid transporter is located in the limiting membrane of lamellar bodies (LBs) in type-II-pneumocytes. Mutations within the ABCA3 gene may functionally impair the transporter, causing lung diseases in newborns, children and adults. Assays to quantify volume and lipid filling of the LBs on the level of the vesicular structures and thereby assess the function of ABCA3 are still lacking. In the present study human influenza haemagglutinin- (HA-) tagged wild type and mutant ABCA3 proteins were stably expressed in lung A549 cells...
September 5, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28886594/elemental-sulfur-use-and-associations-with-pediatric-lung-function-and-respiratory-symptoms-in-an-agricultural-community-california-usa
#4
Rachel Raanan, Robert B Gunier, John R Balmes, Alyssa J Beltran, Kim G Harley, Asa Bradman, Brenda Eskenazi
BACKGROUND: Elemental sulfur, "the oldest of all pesticides," is the most heavily used agricultural pesticide in California and Europe. Sulfur is considered relatively safe and is used in both conventional and organic farming systems. Adverse respiratory effects have been reported in applicators and animals, but the effect on residential populations, and especially on children living in proximity to fields treated with elemental sulfur, is not known. OBJECTIVES: We evaluated associations between residential proximity to elemental sulfur applications and respiratory symptoms and spirometry of children living in an agricultural community...
August 10, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28881145/secondhand-tobacco-smoke-and-severity-in-wheezing-children-nasal-oxidant-stress-and-inflammation
#5
Ozge Yilmaz, Ahmet Turkeli, Ece Onur, Sema Bilge, Hasan Yuksel
OBJECTIVES: Prenatal and postnatal smoke exposures are associated with many lung diseases in children due to impaired lung function, increased inflammation, and oxidative stress. We aimed to determine the influence of secondhand tobacco smoke exposure on the levels of nasal glutathione, IL-8, IL-17, MMP-9, and TIMP-1, as well as serum surfactant protein-D (SP-D) in wheezy children. METHODS: We enrolled 150 children with recurrent wheezing and recorded wheezing characteristics at enrollment...
September 7, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28872938/laps-or-lengths-the-effects-of-different-exercise-programmes-on-asthma-control-in-children
#6
C Carew, Dw Cox
INTRODUCTION: Exercise training has been shown in numerous studies to improve lung function and asthma control in children with asthma. Swimming has been shown to be of benefit in children with asthma, but which form of exercise is better for asthmatics has not been determined to date. The aim of this study was to examine if swimming improved lung function and asthma symptoms in asthmatic children when compared with different forms of exercise and a control group. METHODS: Subjects with asthma were randomly assigned to either one of three different exercise training groups (swimming, football and basketball) or a control group...
September 5, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28871575/inert-gas-washout-background-and-application-in-various-lung-diseases
#7
Jakob Usemann, Sophie Yammine, Florian Singer, Philipp Latzin
Multiple breath inert gas washout (MBW) is a lung function technique to measure ventilation inhomogeneity. The technique was developed more than 60 years ago, but not much used for many decades. Technical improvements, easy protocols and higher sensitivity compared with standard lung function tests in some disease groups have led to a recent renaissance of MBW. The lung clearance index (LCI) is a common measure derived from MBW tests, and offers information on lung pathology complementary to that from conventional lung function tests such as spirometry...
September 5, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28867425/the-association-between-substantiated-childhood-maltreatment-asthma-and-lung-function-a-prospective-investigation
#8
Amanuel Alemu Abajobir, Steve Kisely, Gail Williams, Lane Strathearn, Sadasivam Suresh, Jake Moses Najman
BACKGROUND: Asthma reflects multiple and likely complex causal pathways. We investigate the possibility that childhood maltreatment is one such causal pathway. Childhood maltreatment can be interpreted as a form of early life adversity and like other life adversities may predict a range of negative health outcomes, including asthma. METHODS: A total of 3762 young adults (52.63% female) from the Mater Hospital-University of Queensland Study of Pregnancy (MUSP) participated in this study...
August 3, 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28866644/functional-phenotypes-determined-by-fluctuation-based-clustering-of-lung-function-measurements-in-healthy-and-asthmatic-cohort-participants
#9
Edgar Delgado-Eckert, Oliver Fuchs, Nitin Kumar, Juha Pekkanen, Jean-Charles Dalphin, Josef Riedler, Roger Lauener, Michael Kabesch, Maciej Kupczyk, Sven-Eric Dahlen, Erika von Mutius, Urs Frey
RATIONALE: Asthma is characterised by inflammation and reversible airway obstruction. However, these features are not always closely related. Fluctuations of daily lung function contain information on asthma phenotypes, exacerbation risk and response to long-acting β-agonists. OBJECTIVES: In search of subgroups of asthmatic participants with specific lung functional features, we developed and validated a novel clustering approach to asthma phenotyping, which exploits the information contained within the fluctuating behaviour of twice-daily lung function measurements...
September 2, 2017: Thorax
https://www.readbyqxmd.com/read/28866107/baseline-features-of-the-severe-asthma-research-program-sarp-iii-cohort-differences-with-age
#10
W Gerald Teague, Brenda R Phillips, John V Fahy, Sally E Wenzel, Anne M Fitzpatrick, Wendy C Moore, Annette T Hastie, Eugene R Bleecker, Deborah A Meyers, Stephen P Peters, Mario Castro, Andrea M Coverstone, Leonard B Bacharier, Ngoc P Ly, Michael C Peters, Loren C Denlinger, Sima Ramratnam, Ronald L Sorkness, Benjamin M Gaston, Serpil C Erzurum, Suzy A A Comhair, Ross E Myers, Joe Zein, Mark D DeBoer, Anne-Marie Irani, Elliot Israel, Bruce Levy, Juan Carlos Cardet, Wanda Phipatanakul, Jonathan M Gaffin, Fernando Holguin, Merritt L Fajt, Shean J Aujla, David T Mauger, Nizar N Jarjour
BACKGROUND: The effect of age on asthma severity is poorly understood. OBJECTIVES: The objective of this study was to compare the baseline features of severe and nonsevere asthma in the Severe Asthma Research Program (SARP) III cohort, and examine in cross section the effects of age on those features. METHODS: SARP III is a National Institutes of Health/National Heart Lung Blood Institute multisite 3-year cohort study conducted to investigate mechanisms of severe asthma...
August 30, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28865973/recovery-of-pulmonary-function-after-allogeneic-hematopoietic-cell-transplantation-in-children-is-associated-with-improved-survival
#11
Ashok Srinivasan, Anusha Sunkara, William Mitchell, Sudeep Sunthankar, Guolian Kang, Dennis C Stokes, Saumini Srinivasan
Abnormal pulmonary function is prevalent in survivors of allogeneic hematopoietic cell transplantation. Post-transplant recovery of pulmonary function, and its effect on survival in children is not known. This is a retrospective cohort study of 308 children followed for 10 years after transplantation at a single institution. There were 2 groups of patients. Group 1 included 188 patients with 3 or more pulmonary function test (PFT) results, of which at least 1 was abnormal, group 2 included 120 patients with 3 or more PFTs, all of which were normal...
August 30, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28861397/modulation-of-host-immunity-by-human-respiratory-syncytial-virus-virulence-factors-a-synergic-inhibition-of-both-innate-and-adaptive-immunity
#12
REVIEW
Gisela Canedo-Marroquín, Orlando Acevedo-Acevedo, Emma Rey-Jurado, Juan M Saavedra, Margarita K Lay, Susan M Bueno, Claudia A Riedel, Alexis M Kalergis
The Human Respiratory Syncytial Virus (hRSV) is a major cause of acute lower respiratory tract infections (ARTIs) and high rates of hospitalizations in children and in the elderly worldwide. Symptoms of hRSV infection include bronchiolitis and pneumonia. The lung pathology observed during hRSV infection is due in part to an exacerbated host immune response, characterized by immune cell infiltration to the lungs. HRSV is an enveloped virus, a member of the Pneumoviridae family, with a non-segmented genome and negative polarity-single RNA that contains 10 genes encoding for 11 proteins...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28858191/maximal-respiratory-muscle-strength-and-vital-capacity-in-children-with-early-onset-scoliosis
#13
Gregory Redding, O Henry Mayer, Klane White, Viviana Bompadre, Julia Emerson, Walter Krengel, Robert Campbell
STUDY DESIGN: Descriptive Cross-Sectional Study. OBJECTIVE: To measure respiratory muscle function in children with EOS, determine the frequency of respiratory muscle weakness, and correlate these measures with Vital Capacity, Body Mass Index, and Cobb angle. SUMMARY OF BACKGROUND DATA: Progressive restrictive respiratory disease is common among children with moderate to severe Early Onset Scoliosis (EOS). Reduced respiratory muscle strength is associated with the loss of lung function in adolescents and adults with scoliosis...
August 29, 2017: Spine
https://www.readbyqxmd.com/read/28858095/the-influence-of-inhaled-corticosteroid-discontinuation-in-children-with-well-controlled-asthma
#14
Shengkun Zheng, Qiying Yu, Xiangyan Zeng, Wangming Sun, Yan Sun, Mengrong Li
Asthma is a chronic inflammatory disease that requires adherence to both preventative and therapeutic interventions in disease management. Children with asthma are likely to discontinue inhaled corticosteroids (ICS), especially when symptoms are under control. We aimed to investigate the impact of ICS adherence in children whose symptoms were under control.The study is cohort study; 35 children with controlled asthma that had undergone 3 years of follow-up were included. Serum eosinophil count, serum total IgE (tIgE), and lung function (FEV1, FEV1/FVC, PEF, FEF20-75%, and PC20) were evaluated at the beginning and end of the follow-up...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28837221/tailored-interventions-based-on-sputum-eosinophils-versus-clinical-symptoms-for-asthma-in-children-and-adults
#15
REVIEW
Helen L Petsky, Albert Li, Anne B Chang
BACKGROUND: Asthma severity and control can be measured both subjectively and objectively. Sputum analysis for evaluation of percentage of sputum eosinophilia directly measures airway inflammation, and is one method of objectively monitoring asthma. Using sputum analysis to adjust or tailor asthma medications is potentially superior to traditional methods based on symptoms and spirometry. OBJECTIVES: To evaluate the efficacy of tailoring asthma interventions based on sputum analysis in comparison to traditional methods (usually symptom-based with or without spirometry/peak flow) for asthma-related outcomes in children and adults...
August 24, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28834381/small-airway-oscillometry-indices-repeatability-and-bronchodilator-responsiveness-in-young-children
#16
Hanna Knihtilä, Anne Kotaniemi-Syrjänen, Anna S Pelkonen, Satu Kalliola, Mika J Mäkelä, Leo Pekka Malmberg
INTRODUCTION: The impulse oscillometry (IOS) indices absolute and relative difference between respiratory resistance at 5 and 20 Hz (R5-20 and R5-20%, respectively) and the area under the reactance curve (AX) are postulated to reflect small airway function. Data on their cutoff values to evaluate bronchodilator responsiveness (BDR) or between-visit changes after interventions are limited in young children. METHODS: We evaluated the BDR of 103 healthy children aged 2-7 years, who received either salbutamol (n = 84) or placebo (n = 19) in order to determine cutoff values for BDR of R5-20, R5-20%, and AX...
August 18, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28833810/features-of-asthma-which-provide-meaningful-insights-for-understanding-the-disease-heterogeneity
#17
Matea Deliu, Tolga S Yavuz, Matthew Sperrin, Danielle Belgrave, Umit M Sahiner, Cansin Sackesen, Omer Kalayci, Adnan Custovic
BACKGROUND: Data-driven methods such as hierarchical clustering (HC) and principal component analysis (PCA) have been used to identify asthma subtypes, with inconsistent results. OBJECTIVE: To develop a framework for the discovery of stable and clinically meaningful asthma subtypes. METHODS: We performed HC in a rich dataset from 613 asthmatic children, using 45 clinical variables (Model 1), and after PCA dimensionality reduction (Model 2)...
August 22, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28831262/predictive-value-of-respiratory-symptoms-for-the-diagnosis-of-pollen-induced-seasonal-asthma-among-children-and-adults-in-inner-mongolia
#18
Ting Ting Ma, Yan Zhuang, Hai Ying Gong, Anthony Chauang Yii, Xue Yan Wang, Huan Zhong Shi
BACKGROUND: The diagnosis of asthma is made on the basis of variable respiratory symptoms and supported by objective evidence of variable airflow limitation. However, spirometry and bronchoprovocation tests may not be routinely available in resource-scarce settings or in the context of large-scale epidemiological studies. There is a gap in knowledge about the predictive value of respiratory symptoms for the diagnosis of pollen-induced asthma. OBJECTIVE: The aim of this study was to investigate the predictive value of self-reported respiratory symptoms for diagnosing pollen-induced asthma...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28831038/caesarean-section-is-associated-with-reduced-perinatal-cytokine-response-increased-risk-of-bacterial-colonization-in-the-airway-and-infantile-wheezing
#19
Sui-Ling Liao, Ming-Han Tsai, Tsung-Chieh Yao, Man-Chin Hua, Kuo-Wei Yeh, Chih-Yung Chiu, Kuan-Wen Su, Shih-Yin Huang, Chuan-Chi Kao, Shen-Hao Lai, Jing-Long Huang
The relationship between cesarean section (CS) and allergic disorders such as asthma and wheezing has been inconsistent, and the mechanisms for their connection remained largely unknown. We aimed to investigate whether CS is associated with infantile wheeze and to explore the connection between CS and several risk factors known to correlate with allergy development. Mononuclear cells were isolated from cord blood and assessed for cytokine responses by ELISA. Bacteria from nasopharyngeal specimens were identified with traditional culture methods...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28828295/role-of-vitamin-d-in-cystic-fibrosis-and-non-cystic-fibrosis-bronchiectasis
#20
REVIEW
Maria Moustaki, Ioanna Loukou, Kostas N Priftis, Konstantinos Douros
Bronchiectasis is usually classified as cystic fibrosis (CF) related or CF unrelated (non-CF); the latter is not considered an orphan disease any more, even in developed countries. Irrespective of the underlying etiology, bronchiectasis is the result of interaction between host, pathogens, and environment. Vitamin D is known to be involved in a wide spectrum of significant immunomodulatory effects such as down-regulation of pro-inflammatory cytokines and chemokines. Respiratory epithelial cells constitutively express 1α-hydroxylase leading to the local transformation of the inactive 25(OH)-vitamin D to the active 1,25(OH)2-vitamin D...
August 8, 2017: World Journal of Clinical Pediatrics
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