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M Vailati-Riboni, Z Zhou, C B Jacometo, A Minuti, E Trevisi, D N Luchini, J J Loor
Methionine, together with Lys, is the most limiting AA for milk production in dairy cows. Besides its crucial role in milk production, Met and its derivate metabolites (e.g., glutathione, taurine, polyamines) are well-known immunonutrients in nonruminants, helping support and boost immune function and activity. In the present study, the effects of Met or choline, as its precursor, were investigated using an ex vivo whole blood challenge. The study involved 33 multiparous Holstein cows (from a larger cohort with a factorial arrangement of treatments) assigned from d -21 to +30 relative to parturition to a basal control (CON) diet, CON plus rumen-protected Met (MET, Smartamine M, Adisseo NA, Alpharetta, GA) at a rate of 0...
May 2017: Journal of Dairy Science
María Del Carmen Manzanares Campillo, Jesús Martín Fernández, Mariano Amo Salas, Daniel Casanova Rituerto
BACKGROUND: The use of enteral formulas with immunonutrients in patients with gastrointestinal malignancies susceptible to surgery can reduce postoperative morbidity, at the expense of reduced infectious complications, with the consequent reduction in hospital stay and health care costs. MATERIAL AND METHODS: Prospective randomized study. 84 patients operated on a scheduled basis for resectable colorectal cancer were recruited. In the group YES IN Impact © Oral was administered for 8 days (3 sachets a day), compared with the NOT IN group who did not receive it...
December 9, 2016: Cirugia y Cirujanos
Martin D Rosenthal, Phillip W Carrott, Jayshil Patel, Laszlo Kiraly, Robert G Martindale
Arginine supplementation has the potential to improve the health of patients. Its use in hospitalized patients has been a controversial topic in the nutrition literature, especially concerning supplementation of septic patients. In this article, we review the relevant literature both for and against the use of arginine in critically ill, surgical, and hospitalized patients. The effect of critical illness on arginine metabolism is reviewed, as is its use in septic and critically ill patients. Although mounting evidence supports immunonutrition, there are only a few studies that suggest that this is safe in patients with severe sepsis...
December 2016: Journal of Nutrition
Vance L Albaugh, Carolina Pinzon-Guzman, Adrian Barbul
Arginine is an important player in numerous biologic processes and studies have demonstrated its importance for cellular growth that becomes limiting in states of rapid turnover (e.g., malignancy). Thus, arginine deprivation therapy is being examined as an adjuvant cancer therapy, however, arginine is also necessary for immune destruction of malignant cells. Herein we review the data supporting arginine deprivation or supplementation in cancer treatment and the currently registered trials aimed at understanding these divergent strategies...
March 2017: Journal of Surgical Oncology
Jemma S Cleminson, Stefan P Zalewski, Nicholas D Embleton
PURPOSE OF REVIEW: The increasing recognition of the role of nutritional care for preterm infants continues to result in a proliferation of review articles, systematic reviews, observational studies and trials. In this article, we review a selection of important studies published in the last 12–18 months. RECENT FINDINGS: The selected studies demonstrate the potential importance of light protecting parenteral nutrition solutions, the benefits of standardized concentrated parenteral nutrition solutions and the importance of insulin-like growth factor I in early life...
May 2016: Current Opinion in Clinical Nutrition and Metabolic Care
Harshitha Kota, Ronald S Chamberlain
INTRODUCTION: Graft-versus-host disease (GVHD) is a serious complication of bone marrow transplantation (BMT), requiring higher doses of glucocorticoids or immunosuppressive therapies and further straining transplant recipients. Immunonutrition, such as vitamins and amino acid supplements, increase immunity and decrease inflammation and oxidative stress. This meta-analysis examines the impact of immunonutrition on the incidence of GVHD and postoperative infections among BMT recipients...
August 8, 2016: JPEN. Journal of Parenteral and Enteral Nutrition
Pedro Moya, Leticia Soriano-Irigaray, Jose Manuel Ramirez, Alessandro Garcea, Olga Blasco, Francisco Javier Blanco, Carlo Brugiotti, Elena Miranda, Antonio Arroyo
To compare immunonutrition versus standard high calorie nutrition in patients undergoing elective colorectal resection within an Enhanced Recovery After Surgery (ERAS) program.Despite progress in recent years in the surgical management of patients with colorectal cancer (ERAS programs), postoperative complications are frequent. Nutritional supplements enriched with immunonutrients have recently been introduced into clinical practice. However, the extent to which the combination of ERAS protocols and immunonutrition benefits patients undergoing colorectal cancer surgery is unknown...
May 2016: Medicine (Baltimore)
Pedro Moya, Elena Miranda, Leticia Soriano-Irigaray, Antonio Arroyo, Maria-Del-Mar Aguilar, Marta Bellón, Jose-Luis Muñoz, Fernando Candela, Rafael Calpena
OBJECTIVE: To determine whether the joint implementation of immunonutrition and a laparoscopic approach improves morbidity, mortality, and length of stay (LOS) compared with dietary advice. BACKGROUND: Despite progress in recent years in the surgical management of patients with colorectal cancer, postoperative complications are frequent. Nutritional supplements enriched with immunonutrients have recently been introduced into clinical practice. However, the immunonutrition benefits in patients undergoing colorectal laparoscopic surgery are unknown...
March 2, 2016: Surgical Endoscopy
Naveena B Janakiram, Altaf Mohammed, Venkateshwar Madka, Gaurav Kumar, Chinthalapally V Rao
Epidemiological and laboratory data support the protective effects of bioactive nutrients in our diets for various diseases. Along with various factors, such as genetic history, alcohol, smoking, exercise, and dietary choices play a vital role in affecting an individual's immune responses toward a transforming cell, by either preventing or accelerating a neoplastic transformation. Ample evidence suggests that dietary nutrients control the inflammatory and protumorigenic responses in immune cells. Immunoprevention is usually associated with the modulation of immune responses that help in resolving the inflammation, thus improving clinical outcome...
June 2016: Molecular Nutrition & Food Research
Lucilene Rezende Anastácio, Maria Isabel Toulson Davisson Correia
Managing malnutrition before liver transplantation (LTx) while on the waiting list and, excessive weight gain/metabolic disturbances in post-surgery are still a challenge in LTx care. The aim of this review is to support an interdisciplinary nutrition approach of these patients. Cirrhotic patients are frequently malnourished before LTx and this is associated with a poor prognosis. Although the relation between nutritional status versus survival, successful operation and recovery after LTx is well established, prevalence of malnutrition before the operation is still very high...
January 28, 2016: World Journal of Gastroenterology: WJG
Faïza Khemissa, Laurent Mineur, Caroline Amsellem, Eric Assenat, Mohamed Ramdani, Patrick Bachmann, Chloé Janiszewski, Isabelle Cristiani, Fideline Collin, Julie Courraud, Hélène de Forges, Pierre Dechelotte, Pierre Senesse
BACKGROUND: Patients with gastrointestinal (GI) cancer are exposed to cachexia, which is highly correlated with chemotherapy-induced side effects. Research suggests that specific immunonutrients could prevent such toxicities. AIMS: The primary objective of this phase III study was to evaluate the efficacy of glutamine and transforming growth factor-β2 (TGF-β2) in the prevention of grade 3-4 non-hematological toxicities induced by chemotherapy in patients with GI cancer...
March 2016: Digestive and Liver Disease
Rémy F Meier, Alastair Forbes
Nutrition is a basic requirement for life and plays an important role in health and in disease prevention, but malnutrition is a common event and a cause of increased morbidity and mortality, particularly in patients with disease-related malnutrition showing inflammation and a catabolic state. Malnutrition is often overlooked, and deterioration in the nutritional status following admission to hospital is common. It should be actively pursued by a ubiquitous system of nutrition screening, and full nutritional assessment is required for those found to be at risk...
2015: Nestlé Nutrition Institute Workshop Series
Mustafa Sit, Ahmet S Ilgun, Oguz Catal, Ferda N Koksoy, Gülali Aktas, Alper Cihan
OBJECTIVES: Complications after colorectal surgery have not been reduced in recent years. Anastomotic leakage is responsible for nearly all morbidity in colonic surgery and for about one third of the mortality. MATERIAL AND METHODS: For the study, 34 albino Wistar rats (about 155-190 g in weight) were divided into four experimental groups. Each of the rats underwent an abdominal incision and resection of the colon 4 cm distal to the cecum to form a colo-colonic anastomosis...
May 2015: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Ping Zhou, Yanqi Li, Li-Ya Ma, Hung-Chih Lin
Necrotizing enterocolitis (NEC) is a critical intestinal emergency condition, which mainly occurs in preterm very low birth weight (PVLBW) infants. Despite remarkable advances in the care of PVLBW infants, with considerable improvement of the survival rate in recent decades, the incidence of NEC and NEC-related mortality have not declined accordingly. The fast progression from nonspecific signs to extensive necrosis also makes primary prevention the first priority. Recently, increasing evidence has indicated the important role of several nutrients in primary prevention of NEC...
August 28, 2015: Nutrients
Maria G Annetta, Mauro Pittiruti, Pietro Vecchiarelli, Davide Silvestri, Anselmo Caricato, Massimo Antonelli
Modulation of inflammatory and immune response to critical illness has been the goal of much research in the last decade and a variety of drugs and nutrients (so called "immunonutrients") have been tested in experimental models with promising results. Though, in the clinical setting of intensive care, their efficacy have been inconsistently proven, most likely because the effects of each drug may vary in relation to the timing, the dose, the route of administration, the interaction with other nutrients, the severity of illness and many other factors...
March 2016: Minerva Anestesiologica
Maísa Mota Antunes, Paola Caroline Lacerda Leocádio, Lílian Gonçalves Teixeira, Alda Jusceline Leonel, Denise Carmona Cara, Gustavo Batista Menezes, Simone de Vasconcelos Generoso, Valbert Nascimento Cardoso, Jacqueline Isaura Alvarez-Leite, Maria Isabel Toulson Davisson Correia
BACKGROUND: Mucositis is a common complication in patients undergoing radiotherapy and chemotherapy. It is associated with pain, poor quality of life, and malnutrition, leading to an increased number of hospital admissions and prolonged hospitalization. The use of immunonutrients may be an alternative treatment option, which may help to improve patient outcome. OBJECTIVE: Here we assessed the impact of L-citrulline (CIT) on a murine model of 5-fluorouracil (5FU)-induced mucositis...
February 2016: JPEN. Journal of Parenteral and Enteral Nutrition
Hannah B Tan, Stefan Danilla, Alexandra Murray, Ramón Serra, Regina El Dib, Tom O W Henderson, Jason Wasiak
BACKGROUND: With burn injuries involving a large total body surface area (TBSA), the body can enter a state of breakdown, resulting in a condition similar to that seen with severe lack of proper nutrition. In addition, destruction of the effective skin barrier leads to loss of normal body temperature regulation and increased risk of infection and fluid loss. Nutritional support is common in the management of severe burn injury, and the approach of altering immune system activity with specific nutrients is termed immunonutrition...
2014: Cochrane Database of Systematic Reviews
J Wesley Alexander, Dorothy M Supp
Significance: Only a few decades ago, the primary focus of nutritional supplementation was to prevent deficiencies of essential nutrients. It is now recognized that, at higher than essential levels, selected nutrients can have a pharmacologic effect to prevent or treat disease. Recent Advances: Two of the most important pharmaconutrients, arginine, and the omega-3 polyunsaturated fatty acids in fish oil, have been shown to have profound effects on wound healing and infections. Critical Issues: Both arginine and fish oils have independent benefits, but the combination appears to be much more effective...
November 1, 2014: Advances in Wound Care
Iára Kallyanna Cavalcante Ferreira
BACKGROUND AND OBJECTIVES: The purpose of this review is to approach the main necessary aspects for the accomplishment of safety and efficient nutritional therapy to the critically ill patient. CONTENTS: Bibliographical survey with didactic books and scientific articles was made in Portuguese, English and Spanish with results of the last 20 years. Nutritional support is an integrant part in the care of patients in intensive care units. The success of the nutritional therapy involves the stages of nutritional assessment, determines the route of diet infusion and the calories and nutrients needs...
March 2007: Revista Brasileira de Terapia Intensiva
Dan-Hua Wang
The Global Consensus for Feeding the Preterm Infant was published in the Journal of Pediatrics 3 supplement, 2013. The content of the consensus includes recommended nutrient intake for different gestational age preterm infants, identifying appropriate growth curves, the use of breast milk, nutritional recommendations for the late-preterm infant and the preterm infant after hospital discharge, nutritional requirements and feeding recommendations for small gestation age infants, reconsideration of the importance of vitamin A and vitamin D for immature infants, recommendations for immunonutrients, and the association of feeding of preterm infants with later metabolic and cardiovascular outcomes...
July 2014: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
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