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https://www.readbyqxmd.com/read/27875410/should-we-use-driving-pressure-to-set-tidal-volume
#1
Domenico L Grieco, Lu Chen, Martin Dres, Laurent Brochard
PURPOSE OF REVIEW: Ventilator-induced lung injury (VILI) can occur despite use of tidal volume (VT) limited to 6 ml/kg of predicted body weight, especially in patients with a smaller aerated compartment (i.e. the baby lung) in which, indeed, tidal ventilation takes place. Because respiratory system static compliance (CRS) is mostly affected by the volume of the baby lung, the ratio VT/CRS (i.e. the driving pressure, ΔP) may potentially help tailoring interventions on VT setting. RECENT FINDINGS: Driving pressure is the ventilatory variable most strongly associated with changes in survival and has been shown to be the key mediator of the effects of mechanical ventilation on outcome in the acute respiratory distress syndrome...
November 19, 2016: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/27784322/spontaneous-breathing-trial-and-post-extubation-work-of-breathing-in-morbidly-obese-critically-ill-patients
#2
Martin Mahul, Boris Jung, Fabrice Galia, Nicolas Molinari, Audrey de Jong, Yannaël Coisel, Rosanna Vaschetto, Stefan Matecki, Gérald Chanques, Laurent Brochard, Samir Jaber
BACKGROUND: Predicting whether an obese critically ill patient can be successfully extubated may be specially challenging. Several weaning tests have been described but no physiological study has evaluated the weaning test that would best reflect the post-extubation inspiratory effort. METHODS: This was a physiological randomized crossover study in a medical and surgical single-center Intensive Care Unit, in patients with body mass index (BMI) >35 kg/m(2) who were mechanically ventilated for more than 24 h and underwent a weaning test...
October 27, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27768396/effort-to-breathe-with-various-spontaneous-breathing-trial-techniques-a-physiological-meta-analysis
#3
Michael C Sklar, Karen Burns, Nuttapol Rittayamai, Ashley Lanys, Michela Rauseo, Lu Chen, Martin Dres, Guang-Qiang Chen, Ewan C Goligher, Neill Kj Adhikari, Laurent Brochard, Jan O Friedrich
Introduction Spontaneous breathing trials (SBTs) are designed to simulate conditions following extubation and it is essential to understand the physiological impact of different methods. We conducted a systematic review and pooled measures reflecting patient respiratory effort among studies comparing SBT methods in a meta-analysis. Methods We searched Medline, EMBASE, and Web of Science from inception to January 2016 to identify randomized and non-randomized clinical trials reporting physiological measurements of respiratory effort (pressure-time product, PTP) or work of breathing during at least 2 SBT techniques...
October 21, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27757516/potentially-modifiable-factors-contributing-to-outcome-from-acute-respiratory-distress-syndrome-the-lung-safe-study
#4
John G Laffey, Giacomo Bellani, Tài Pham, Eddy Fan, Fabiana Madotto, Ednan K Bajwa, Laurent Brochard, Kevin Clarkson, Andres Esteban, Luciano Gattinoni, Frank van Haren, Leo M Heunks, Kiyoyasu Kurahashi, Jon Henrik Laake, Anders Larsson, Daniel F McAuley, Lia McNamee, Nicolas Nin, Haibo Qiu, Marco Ranieri, Gordon D Rubenfeld, B Taylor Thompson, Hermann Wrigge, Arthur S Slutsky, Antonio Pesenti
PURPOSE: To improve the outcome of the acute respiratory distress syndrome (ARDS), one needs to identify potentially modifiable factors associated with mortality. METHODS: The large observational study to understand the global impact of severe acute respiratory failure (LUNG SAFE) was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted in the winter of 2014 in a convenience sample of 459 ICUs from 50 countries across five continents...
October 18, 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/27753501/non-invasive-ventilation-of-patients-with-ards-insights-from-the-lung-safe-study
#5
Giacomo Bellani, John G Laffey, Tài Pham, Fabiana Madotto, Eddy Fan, Laurent Brochard, Andres Esteban, Luciano Gattinoni, Vesna Bumbasirevic, Lise Piquilloud, Frank van Haren, Anders Larsson, Daniel F McAuley, Philippe R Bauer, Yaseen M Arabi, Marco Ranieri, Massimo Antonelli, Gordon D Rubenfeld, B Taylor Thompson, Hermann Wrigge, Arthur S Slutsky, Antonio Pesenti
BACKGROUND: Non-invasive ventilation (NIV) is increasingly used in patients with Acute Respiratory Distress Syndrome (ARDS). Whether, during NIV, the categorization of ARDS severity based on the PaO2/FiO2 Berlin criteria is useful is unknown. The evidence supporting NIV use in patients with ARDS remains relatively sparse. METHODS: The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study described the management of patients with ARDS...
October 18, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27748627/partial-neuromuscular-blockade-during-partial-ventilatory-support-in-sedated-patients-with-high-tidal-volumes
#6
Jonne Doorduin, Joeke L Nollet, Lisanne H Roesthuis, Hieronymus W H van Hees, Laurent J Brochard, Christer A Sinderby, Johannes G van der Hoeven, Leo M A Heunks
RATIONALE: Controlled mechanical ventilation is used to deliver lung-protective ventilation in patients with acute respiratory distress syndrome. Despite recognized benefits, such as preserved diaphragm activity, partial support ventilation modes may be incompatible with lung-protective ventilation due to high tidal volume and high transpulmonary pressure. As an alternative to high dose sedatives and controlled mechanical ventilation, pharmacologically induced neuromechanical uncoupling of the diaphragm should facilitate lung-protective ventilation under partial support modes...
October 17, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27747049/high-flow-nasal-cannula-in-postextubation-management
#7
COMMENT
Lu Chen, Hong-Liang Li, Laurent Brochard
No abstract text is available yet for this article.
September 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27736154/a-multicenter-randomized-trial-assessing-the-efficacy-of-helium-oxygen-in-severe-exacerbations-of-chronic-obstructive-pulmonary-disease
#8
Philippe Jolliet, Lamia Ouanes-Besbes, Fekri Abroug, Jalila Ben Khelil, Mohamed Besbes, Aude Garnero, Jean-Michel Arnal, Fabrice Daviaud, Jean-Daniel Chiche, Benoît Lortat-Jacob, Jean-Luc Diehl, Nicolas Lerolle, Alain Mercat, Keyvan Razazi, Christian Brun-Buisson, Isabelle Durand-Zaleski, Joëlle Texereau, Laurent Brochard
RATIONALE: During non-invasive ventilation (NIV) for COPD exacerbations, Helium/Oxygen (He/O2) reduces work of breathing and hypercapnia more than Air/O2 but impact on clinical outcome remains unknown. OBJECTIVE: To determine whether continuous administration of He/O2 for 72 hours, during and in-between NIV sessions, is superior to Air/O2 in reducing NIV failure (25% to 15%) in severe hypercapnic COPD exacerbations. METHODS: Prospective, randomized, open-label trial (16 intensive care units, 6 countries)...
October 13, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27686459/esicm-lives-2016-part-three-milan-italy-1-5-october-2016
#9
T Velasquez, G Mackey, J Lusk, U G Kyle, T Fontenot, P Marshall, L S Shekerdemian, J A Coss-Bu, A Nishigaki, T Yatabe, T Tamura, K Yamashita, M Yokoyama, J C Ruiz-Rodriguez, B Encina, R Belmonte, I Troncoso, P Tormos, M Riveiro, J Baena, A Sanchez, J Bañeras, J Cordón, N Duran, A Ruiz, J Caballero, X Nuvials, J Riera, J Serra, A M F Rutten, S N M van Ieperen, E P H M Der Kinderen, T Van Logten, L Kovacikova, P Skrak, M Zahorec, U G Kyle, A Akcan-Arikan, J C Silva, G Mackey, J Lusk, M Goldsworthy, L S Shekerdemian, J A Coss-Bu, D Wood, D Harrison, R Parslow, P Davis, J Pappachan, S Goodwin, P Ramnarayan, S Chernyshuk, H Yemets, V Zhovnir, S M Pulitano', S De Rosa, A Mancino, G Villa, F Tosi, P Franchi, G Conti, B Patel, H Khine, A Shah, D Sung, L Singer, S Haghbin, S Inaloo, Z Serati, M Idei, T Nomura, N Yamamoto, Y Sakai, T Yoshida, Y Matsuda, Y Yamaguchi, S Takaki, O Yamaguchi, T Goto, N Longani, S Medar, I R Abdel-Aal, A S El Adawy, H M E H Mohammed, A N Mohamed, S M Parry, L D Knight, L Denehy, N De Morton, C E Baldwin, D Sani, G Kayambu, V Z M da Silva, P Phongpagdi, Z A Puthucheary, C L Granger, J E Rydingsward, C M Horkan, K B Christopher, D McWilliams, C Jones, E Reeves, G Atkins, C Snelson, L M Aitken, J Rattray, J Kenardy, A M Hull, A Ullman, R Le Brocque, M Mitchell, C Davis, B Macfarlane, J C Azevedo, L L Rocha, F F M De Freitas, A M Cavalheiro, N M Lucinio, M S Lobato, G Ebeling, A Kraegpoeth, E Laerkner, I De Brito-Ashurst, C White, S Gregory, L G Forni, E Flowers, A Curtis, C A Wood, K Siu, K Venkatesan, J B H Muhammad, L Ng, E Seet, N Baptista, A Escoval, E Tomas, R Agrawal, R Mathew, A Varma, E Dima, E Charitidou, E Perivolioti, M Pratikaki, C Vrettou, A Giannopoulos, S Zakynthinos, C Routsi, E Atchade, S Houzé, S Jean-Baptiste, G Thabut, C Genève, S Tanaka, B Lortat-Jacob, P Augustin, M Desmard, P Montravers, F J González de Molina, S Barbadillo, R Alejandro, F Álvarez-Lerma, J Vallés, R M Catalán, E Palencia, A Jareño, R M Granada, M L Ignacio, N Cui, D Liu, H Wang, L Su, H Qiu, R Li, K Jaffal, A Rouzé, J Poissy, B Sendid, S Nseir, E Paramythiotou, M Rizos, F Frantzeskaki, A Antoniadou, S Vourli, L Zerva, A Armaganidis, J Riera, J Gottlieb, M Greer, O Wiesner, M Martínez, M Acuña, J Rello, T Welte, E Atchade, T Mignot, S Houzé, S Jean-Baptiste, G Thabut, B Lortat-Jacob, S Tanaka, P Augustin, M Desmard, P Montravers, S Soussi, E Dudoignon, A Ferry, M Chaussard, M Benyamina, A Alanio, S Touratier, M Chaouat, M Lafaurie, M Mimoun, A Mebazaa, M Legrand, M A Sheils, C Patel, L Mohankumar, N Akhtar, S K Pacheco Noriega, N Navarrete Aldana, J L Ávila León, J Durand Baquero, F Fernández Bernal, E Ahmadnia, J S Hadley, M Millar, D Hall, H Hewitt, H Yasuda, M Sanui, T Komuro, S Kawano, K Andoh, H Yamamoto, E Noda, J Hatakeyama, N Saitou, H Okamoto, A Kobayashi, T Takei, S Matsukubo, H B Rotzel, A Serrano Lázaro, D Aguillón Prada, M Rodriguez Gimillo, O Diaz Barinas, M L Blasco Cortes, J Ferreres Franco, J M Segura Roca, A Carratalá, B Gonçalves, R Turon, A Mendes, F Miranda, P J Mata, D Cavalcanti, N Melo, P Lacerda, P Kurtz, C Righy, L E de la Cruz Rosario, S P Gómez Lesmes, J C García Romero, A N García Herrera, E D Díaz Pertuz, M J Gómez Sánchez, E Regidor Sanz, J Barado Hualde, A Ansotegui Hernández, J M Guergué Irazabal, V Spatenkova, O Bradac, P Suchomel, T Urli, E Heusch Lazzeri, R Aspide, M Zanello, L Perez-Borrero, J M Garcia-Alvarez, M D Arias-Verdu, E Aguilar-Alonso, R Rivera-Fernandez, J Mora-Ordoñez, C De La Fuente-Martos, E Castillo-Lorente, F Guerrero-Lopez, S P Gómez Lesmes, L E De la Cruz Rosario, E D Díaz Pertuz, A Ansotegui Hernández, J C García Romero, M J Gómez Sánchez, A N García Herrera, J Roldán Ramírez, E Regidor Sanz, J Barado Hualde, J P Tirapu León, L Navarro-Guillamón, S Cordovilla-Guardia, A Iglesias-Santiago, F Guerrero-López, E Fernández-Mondéjar, A Vidal, M Perez, A Juez, N Arias, L Colino, J L Perez, H Pérez, P Calpe, M A Alcala, D Robaglia, C Perez, S K Lan, M M Cunha, T Moreira, F Santos, E Lafuente, M J Fernandes, J G Silva, L E de la Cruz Rosario, S P Gómez Lesmes, A N García Herrera, J C García Romero, E D Díaz Pertuz, M J Gómez Sánchez, E Regidor Sanz, J G Armando Echeverría, A Ansotegui Hernández, J Barado Hualde, V Podlepich, E Sokolova, E Alexandrova, K Lapteva, P Kurtz, C Shuinotsuka, L Rabello, G Vianna, A Reis, C Cairus, J Salluh, F Bozza, J C Barrios Torres, N J Fernández Araujo, P García-Olivares, E Keough, M Dalorzo, L K Tang, I De Sousa, M Díaz, L J Marcos-Zambrano, J E Guerrero, S E Zamora Gomez, G D Hernandez Lopez, A I Vazquez Cuellar, O R Perez Nieto, J A Castanon Gonzalez, D Bhasin, S Rai, H Singh, O Gupta, M K Bhattal, S Sampley, K Sekhri, R Nandha, F A Aliaga, F Olivares, F Appiani, P Farias, F Alberto, A Hernández, S Pons, R Sonneville, L Bouadma, M Neuville, E Mariotte, A Radjou, J Lebut, S Chemam, G Voiriot, M P Dilly, B Mourvillier, R Dorent, P Nataf, M Wolff, J F Timsit, O Ediboglu, S Ataman, H Ozkarakas, C Kirakli, A Vakalos, V Avramidis, O Obukhova, I A Kurmukov, S Kashiya, E Golovnya, V N Baikova, T Ageeva, T Haritydi, E V Kulaga, J J Rios-Toro, L Perez-Borrero, E Aguilar-Alonso, M D Arias-Verdu, J M Garcia-Alvarez, C Lopez-Caler, C De La Fuente-Martos, S Rodriguez-Fernandez, M Gomez Sanchez-Orézzoli, F Martin-Gallardo, J Nikhilesh, V Joshi, E Villarreal, J Ruiz, M Gordon, A Quinza, J Gimenez, M Piñol, A Castellanos, P Ramirez, Y D Jeon, W Y Jeong, M H Kim, I Y Jeong, M Y Ahn, J Y Ahn, S H Han, J Y Choi, Y G Song, J M Kim, N S Ku, H Shah, F Kellner, F Rezai, N Mistry, P Yodice, V Ovnanian, K Fless, E Handler, R Martínez Alejos, J D Martí Romeu, D González Antón, A Quinart, A Torres Martí, M Llaurado-Serra, A Lobo-Civico, A Ventura-Rosado, A Piñol-Tena, M Pi-Guerrero, C Paños-Espinosa, M Peralvo-Bernat, J Marine-Vidal, R Gonzalez-Engroba, N Montesinos-Cerro, M Treso-Geira, A Valeiras-Valero, L Martinez-Reyes, A Sandiumenge, M F Jimenez-Herrera, S Helyar, P Riozzi, A Noon, G Hallows, H Cotton, J Keep, P A Hopkins, A Taggu, S Renuka, S Sampath, P J T Rood, T Frenzel, R Verhage, M Bonn, P Pickkers, J G van der Hoeven, M van den Boogaard, F Corradi, L Melnyk, F Moggia, R Pienovi, G Adriano, C Brusasco, L Mariotti, M Lattuada, M J Bloomer, M Coombs, K Ranse, R Endacott, B Maertens, K Blot, S Blot, M P van Nieuw Amerongen, E S van der Heiden, J W R Twisk, A R J Girbes, J J Spijkstra, P Riozzi, S Helyar, H Cotton, G Hallows, A Noon, C Bell, K Peters, A Feehan, J Keep, P A Hopkins, K Churchill, K Hawkins, R Brook, N Paver, R Endacott, N Maistry, A van Wijk, N Rouw, T van Galen, S Evelein-Brugman, A Taggu, B Krishna, S Sampath, A Putzu, M Fang, M Boscolo Berto, A Belletti, T Cassina, L Cabrini, M Mistry, Y Alhamdi, I Welters, S T Abrams, C H Toh, H S Han, E M Gil, D S Lee, C M Park, S Winder-Rhodes, R Lotay, J Doyle, M W Ke, W C Huang, C H Chiang, W T Hung, C C Cheng, K C Lin, S C Lin, K R Chiou, S R Wann, C W Shu, P L Kang, G Y Mar, C P Liu, S Dubó, A Aquevedo, M Jibaja, D Berrutti, C Labra, R Lagos, M F García, V Ramirez, M Tobar, F Picoita, C Peláez, D Carpio, L Alegría, C Hidalgo, K Godoy, J Bakker, G Hernández, Y Sadamoto, K Katabami, T Wada, Y Ono, K Maekawa, M Hayakawa, A Sawamura, S Gando, H Marin-Mateos, J L Perez-Vela, R Garcia-Gigorro, M A Corres Peiretti, M J Lopez-Gude, S Chacon-Alves, E Renes-Carreño, J C Montejo-González, K L Parlevliet, H R W Touw, M Beerepoot, C Boer, P W G Elbers, P R Tuinman, S A Abdelmonem, T A Helmy, I El Sayed, S Ghazal, S H Akhlagh, M Masjedi, K Hozhabri, E Kamali, I Zýková, B Paldusová, P Sedlák, D Morman, A M Youn, Y Ohta, M Sakuma, D Bates, T Morimoto, P L Su, W Y Chang, W C Lin, C W Chen, F Facchin, F Zarantonello, G Panciera, A De Cassai, A Venrdramin, A Ballin, T Tonetti, P Persona, C Ori, L Del Sorbo, S Rossi, G Vergani, M Cressoni, D Chiumello, C Chiurazzi, M Brioni, I Algieri, T Tonetti, M Guanziroli, A Colombo, I Tomic, A Colombo, F Crimella, E Carlesso, V Gasparovic, L Gattinoni, A Serpa Neto, M Schmidt, T Pham, A Combes, M Gama de Abreu, P Pelosi, M J Schultz, B H Katira, D Engelberts, R E Giesinger, C Ackerley, T Yoshida, D Zabini, G Otulakowski, M Post, W M Kuebler, P J McNamara, B P Kavanagh, R Pirracchio, M Resche Rigon, M Carone, S Chevret, D Annane, S Eladawy, M El-Hamamsy, N Bazan, M Elgendy, G De Pascale, M S Vallecoccia, S L Cutuli, V Di Gravio, M A Pennisi, G Conti, M Antonelli, D T Andreis, W Khaliq, M Singer, J Hartmann, S Harm, S Alcantara Carmona, P Matia Almudevar, A Naharro Abellán, J Veganzones Ramos, L Pérez Pérez, B Lobo Valbuena, N Martínez Sanz, I Fernández Simón, M Arrigo, E Feliot, N Deye, A Cariou, B Guidet, S Jaber, M Leone, M Resche-Rigon, A Vieillard Baron, M Legrand, E Gayat, A Mebazaa, M Balik, I Kolnikova, M Maly, P Waldauf, G Tavazzi, J Kristof, A Herpain, F Su, E Post, F Taccone, J L Vincent, J Creteur, C Lee, F Hatib, Z Jian, S Buddi, M Cannesson, S Fileković, M Turel, R Knafelj, V Gorjup, R Stanić, P Gradišek, O Cerović, T Mirković, M Noč, J Tirkkonen, H Hellevuo, K T Olkkola, S Hoppu, K C Lin, W T Hung, C C Chiang, W C Huang, W C Juan, S C Lin, C C Cheng, P H Lin, K Y Fong, D S Hou, P L Kang, S R Wann, Y S Chen, G Y Mar, C P Liu, M Paul, W Bougouin, G Geri, F Dumas, B Champigneulle, S Legriel, J Charpentier, J P Mira, C Sandroni, A Cariou, J Zimmerman, E Sullivan, M Noursadeghi, B Fox, D Sampson, L McHugh, T Yager, S Cermelli, T Seldon, S Bhide, R A Brandon, R B Brandon, J Zwaag, R Beunders, P Pickkers, M Kox, F Gul, M K Arslantas, D Genc, N Zibandah, L Topcu, T Akkoc, I Cinel, E Greco, M P Lauretta, D T Andreis, M Singer, I Palacios Garcia, M Cordero, A Diaz Martin, T Aldabó Pallás, J Garnacho Montero, J Revuelto Rey, L Roman Malo, A A Tanaka Montoya, A D C Amador Martinez, L Y Delgado Ayala, E Monares Zepeda, J Franco Granillo, J Aguirre Sanchez, G Camarena Alejo, A Rugerio Cabrera, A Pedraza Montenegro, T Pham, G Beduneau, F Schortgen, L Piquilloud, E Zogheib, M Jonas, F Grelon, I Runge, N Terzi, S Grangé, G Barberet, P G Guitard, J P Frat, A Constan, J M Chrétien, J Mancebo, A Mercat, J C M Richard, L Brochard, E Soilemezi, E Koco, S Savvidou, C Nouris, D Matamis, R Di Mussi, S Spadaro, C A Volta, M Mariani, A Colaprico, C Antonio, F Bruno, S Grasso, A Rodriguez, I Martín-Loeches, E Díaz, J R Masclans, F Gordo, J Solé-Violán, M Bodí, F X Avilés-Jurado, S Trefler, M Magret, L F Reyes, J Marín-Corral, J C Yebenes, A Esteban, A Anzueto, S Aliberti, M I Restrepo, J Skytte Larsson, B Redfors, S E Ricksten, R Haines, J Powell-Tuck, H Leonard, M Ostermann, R E Berthelsen, T S Itenov, A Perner, J U Jensen, M Ibsen, A E K Jensen, M H Bestle, T Bucknall, J Dixon, F Boa, I MacPhee, B J Philips, J Doyle, F Saadat, T Samuels, S Huddart, B McCormick, R DeBrunnar, J Preece, M Swart, C Peden, S Richardson, L Forni, P Kalfon, K Baumstarck, P Estagnasie, M A Geantot, A Berric, G Simon, B Floccard, T Signouret, M Boucekine, M Fromentin, M Nyunga, A Sossou, M Venot, R Robert, A Follin, A Renault, M Garrouste, O Collange, Q Levrat, I Villard, D Thévenin, J Pottecher, R G Patrigeon, N Revel, C Vigne, O Mimoz, P Auquier, S Pawar, T Jacques, K Deshpande, R Pusapati, B Wood, R A Pulham, J Wray, K Brown, C Pierce, S Nadel, P Ramnarayan, J R Azevedo, W S Montenegro, D P Rodrigues, S C Sousa, V F Araujo, A L Leitao, P H Prazeres, A V Mendonca, M P Paula, A Das Neves, C I Loudet, M Busico, D Vazquez, D Villalba, A Lischinsky, M Veronesi, M Emmerich, E Descotte, A Juliarena, M Carboni Bisso, M Grando, A Tapia, M Camargo, D Villani Ulla, L Corzo, H Placido Dos Santos, A Ramos, J A Doglia, E Estenssoro, M Carbonara, S Magnoni, C L Mac Donald, J S Shimony, V Conte, F Triulzi, F Stretti, M Macrì, A Z Snyder, N Stocchetti, D L Brody, V Podlepich, V Shimanskiy, I Savin, K Lapteva, A Chumaev, M C Tjepkema-Cloostermans, J Hofmeijer, A Beishuizen, H Hom, M J Blans, M J A M van Putten, L Longhi, B Frigeni, M Curinga, D Mingone, S Beretta, A Patruno, L Gandini, A Vargiolu, F Ferri, R Ceriani, M R Rottoli, L Lorini, G Citerio, S 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Regidor Sanz, M J Gómez Sánchez, S Aldunate Calvo, A N García Herrera, J Barado Hualde, O Agudo Pascual, J P Tirapu León, A Corona, C Ruffini, A Spazzadeschi, F Marrazzo, A Gandola, R Sciurti, C Savi, E Catena, M W Ke, C C Cheng, W C Huang, C H Chiang, W T Hung, K C Lin, S C Lin, S R Wann, K R Chiou, C J Tseng, P L Kang, G Y Mar, C P Liu, P Bertini, F De Sanctis, F Guarracino, P Bertini, R Baldassarri, F Guarracino, S H Buitinck, P H J van der Voort, J Oto, E Nakataki, Y Tsunano, M Izawa, N Tane, M Onodera, M Nishimura, S Ghosh, A Gupta, A De Gasperi, E Mazza, R Limuti, M Prosperi, N Bissenova, A Yergaliyeva, L Talan, G Yılmaz, G Güven, F Yoruk, N D Altıntas, D N Mukherjee, L K Agarwal, K Mandal, M Palomar, B Balsera, M Vallverdu, M Martinez, M Garcia, D Castellana, R Lopez, F Barcenilla, G E Kaminsky, R Carreño, A Escribá, M Fuentes, V Gálvez, R Del Olmo, B Nieto, C Vaquerizo, J Alvarez, M A De la Torre, E Torres, E Bogossian, S Aranha Nouer, D Ribeiro Salgado, S Carvalho Brugger, G Jiménez Jiménez, M Miralbés Torner, M Vallverdú Vidal, B Balsera Garrido, X Nuvials Casals, F Barcenilla Gaite, J Trujillano Cabello, M Palomar Martínez, M Doganci, S Izdes, S Guzeldag Besevli, A Alkan, B Kayaaslan, C Sánchez Ramírez, L Caipe Balcázar, M Cabrera Santana, M A Hernández Viera, S Hípola Escalada, C F Lübbe Vázquez, S M Marrero Penichet, F Artiles Campelo, M A De La Cal López, P Saavedra Santana, S Ruíz Santana, X Repessé, M Artiguenave, S Paktoris-Papine, F Espinasse, A Dinh, F El Sayed, C Charron, G Géri, A Vieillard-Baron, K Marmanidou, M Oikonomou, C Nouris, K Dimitroulakis, E Soilemezi, D Matamis, A Ferré, M Guillot, J L Teboul, D Lichtenstein, G Mézière, C Richard, X Monnet, T Pham, G Beduneau, F Schortgen, L Piquilloud, E Zogheib, M Jonas, F Grelon, I Runge, N Terzi, S Grangé, G Barberet, P G Guitard, J P Frat, A Constan, J M Chrétien, J Mancebo, A Mercat, J C M Richard, L Brochard, S Prīdāne, O Sabeļņikovs, F Mojoli, A Orlando, I Bianchi, F Torriglia, S Bianzina, M Pozzi, G A Iotti, A Braschi, G Beduneau, T Pham, F Schortgen, L Piquilloud, E Zogheib, M Jonas, F Grelon, I Runge, N Terzi, S Grangé, G Barberet, P G Guitard, J P Frat, A Constan, J M Chrétien, J Mancebo, A Mercat, J C M Richard, L Brochard, E Kondili, C Psarologakis, S Kokkini, V Amargianitakis, D Babalis, A Chytas, I Chouvarda, K Vaporidi, D Georgopoulos, O Trapp, A Kalenka, F Mojoli, A Orlando, I Bianchi, F Torriglia, S Bianzina, M Pozzi, G A Iotti, A Braschi, J A Benítez Lozano, P Carmona Sánchez, J E Barrueco Francioni, F Ruiz Ferrón, J M Serrano Simón, S Spadaro, D S Karbing, A Gioia, F Moro, F Dalla Corte, T Mauri, C A Volta, S E Rees, M V Petrova, R Mohan, A V Butrov, S D Beeharry, M V Vatsik, F I Sakieva, F Gobert, H Yonis, R Tapponnier, R Fernandez, M A Labaune, J F Burle, J Barbier, B Vincent, M Cleyet, J C Richard, C Guérin, C Righy Shinotsuka, J Creteur, F S Taccone, S Törnblom, S Nisula, S Vaara, M Poukkanen, S Andersson, V Pettilä, E Pesonen, Z Xie, X Liao, Y Kang, J Zhang, K Kubota, M Egi, S Mizobuchi, S Hegazy, A El-Keraie, E El Sayed, M Abd El Hamid, N J Rodrigues, M Pereira, I Godinho, J Gameiro, M Neves, J Gouveia, Z Costa E Silva, J A Lopes, J Mckinlay, M Kostalas, G Kooner, G Dudas, A Horton, C Kerr, N Karanjia, B Creagh-Brown, L Forni, A Yamazaki, M Sanz Ganuza, J A Martinez Molina, F Hidalgo Martinez, M T Chiquito Freile, N Garcia Fernandez, P Medrano Travieso, A Bandert, R Frithiof, M Lipcsey, D Smekal, P Schlaepfer, J D Durovray, V Plouhinec, C Chiappa, R Bellomo, A G Schneider, S Mitchell, J Durrant, H Street, E Dunthorne, J Shears, C Hernandez Caballero, R Hutchison, S Schwarze, S Ghabina, E Thompson, J R Prowle, C J Kirwan, C A Gonzalez, J L Pinto, V Orozco, J A Patiño, P K Garcia, K M Contreras, P Rodriguez, J E Echeverri
No abstract text is available yet for this article.
September 2016: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27626833/mechanical-ventilation-to-minimize-progression-of-lung-injury-in-acute-respiratory-failure
#10
Laurent Brochard, Arthur Slutsky, Antonio Pesenti
Mechanical Ventilation (MV) is used to sustain life in patients with acute respiratory failure. A major concern in mechanically ventilated patients is the risk of Ventilator-Induced Lung Injury (VILI), which is partially prevented by lung protective ventilation. Spontaneously breathing, non-intubated, patients with acute respiratory failure may have a high respiratory drive and breathe with large tidal volumes and potentially injurious transpulmonary pressure swings. In patients with existing lung injury, regional forces generated by the respiratory muscles may lead to injurious effects on a regional level...
September 14, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27626706/epidemiology-of-weaning-outcome-according-to-a-new-definition-the-wind-study
#11
Gaëtan Béduneau, Tài Pham, Frédérique Schortgen, Lise Piquilloud, Elie Zogheib, Maud Jonas, Fabien Grelon, Isabelle Runge, Nicolas Terzi, Steven Grangé, Guillaume Barberet, Pierre-Gildas Guitard, Jean-Pierre Frat, Adrien Constan, Jean-Marie Chretien, Jordi Mancebo, Alain Mercat, Jean-Christophe M Richard, Laurent Brochard
RATIONALE: The weaning process concerns all patients receiving mechanical ventilation. A previous classification into simple, prolonged and difficult weaning ignored weaning failure and presupposed the use of spontaneous breathing trials. OBJECTIVES: To describe the weaning process defined as starting with any attempt at separation from mechanical ventilation and its prognosis, according to a new operational classification working for all patients under ventilation...
September 14, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27609843/multivariable-fractional-polynomial-interaction-to-investigate-continuous-effect-modifiers-in-a-meta-analysis-on-higher-versus-lower-peep-for-patients-with-ards
#12
Benjamin Kasenda, Willi Sauerbrei, Patrick Royston, Alain Mercat, Arthur S Slutsky, Deborah Cook, Gordon H Guyatt, Laurent Brochard, Jean-Christophe M Richard, Thomas E Stewart, Maureen Meade, Matthias Briel
OBJECTIVES: A recent individual patient data (IPD) meta-analysis suggested that patients with moderate or severe acute respiratory distress syndrome (ARDS) benefit from higher positive end-expiratory pressure (PEEP) ventilation strategies. However, thresholds for continuous variables (eg, hypoxaemia) are often arbitrary and linearity assumptions in regression approaches may not hold; the multivariable fractional polynomial interaction (MFPI) approach can address both problems. The objective of this study was to apply the MFPI approach to investigate interactions between four continuous patient baseline variables and higher versus lower PEEP on clinical outcomes...
September 8, 2016: BMJ Open
https://www.readbyqxmd.com/read/27586996/associations-between-ventilator-settings-during-extracorporeal-membrane-oxygenation-for-refractory-hypoxemia-and-outcome-in-patients-with-acute-respiratory-distress-syndrome-a-pooled-individual-patient-data-analysis-mechanical-ventilation-during-ecmo
#13
Ary Serpa Neto, Matthieu Schmidt, Luciano C P Azevedo, Thomas Bein, Laurent Brochard, Gernot Beutel, Alain Combes, Eduardo L V Costa, Carol Hodgson, Christian Lindskov, Matthias Lubnow, Catherina Lueck, Andrew J Michaels, Jose-Artur Paiva, Marcelo Park, Antonio Pesenti, Tài Pham, Michael Quintel, V Marco Ranieri, Michael Ried, Roberto Roncon-Albuquerque, Arthur S Slutsky, Shinhiro Takeda, Pier Paolo Terragni, Marie Vejen, Steffen Weber-Carstens, Tobias Welte, Marcelo Gama de Abreu, Paolo Pelosi, Marcus J Schultz
PURPOSE: Extracorporeal membrane oxygenation (ECMO) is a rescue therapy for patients with acute respiratory distress syndrome (ARDS). The aim of this study was to evaluate associations between ventilatory settings during ECMO for refractory hypoxemia and outcome in ARDS patients. METHODS: In this individual patient data meta-analysis of observational studies in adult ARDS patients receiving ECMO for refractory hypoxemia, a time-dependent frailty model was used to determine which ventilator settings in the first 3 days of ECMO had an independent association with in-hospital mortality...
September 1, 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/27453169/prevalence-and-characteristics-of-acid-gastro-oesophageal-reflux-disease-in-jackhammer-oesophagus
#14
Anne-Laure Mallet, Alain Ropert, Guillaume Bouguen, Laurent Siproudhis, Dominique Boutroux, Jean-François Bretagne, Charlène Brochard
BACKGROUND: An association between acid gastro-oesophageal reflux disease (GERD) and Jackhammer oesophagus has been suggested. AIM: To assess the prevalence and characteristics of acid-GERD in Jackhammer oesophagus and the efficacy of proton pump inhibitors. METHODS: Data and outcomes of patients with Jackhammer oesophagus were assessed. Two groups were compared: (i) GERD, defined by endoscopic oesophagitis or by an increase in acid exposure time or by an acid-hypersensitive oesophagus and (ii) non-GERD defined by normal oesophageal acid exposure without acid-hypersensitive oesophagus...
October 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27420486/first-investigation-of-the-noise-and-modulation-properties-of-the-carrier-envelope-offset-in-a-modelocked-semiconductor-laser
#15
Pierre Brochard, Nayara Jornod, Stéphane Schilt, Valentin J Wittwer, Sargis Hakobyan, Dominik Waldburger, Sandro M Link, Cesare G E Alfieri, Matthias Golling, Laurent Devenoges, Jacques Morel, Ursula Keller, Thomas Südmeyer
We present the first characterization of the noise properties and modulation response of the carrier-envelope offset (CEO) frequency in a semiconductor modelocked laser. The CEO beat of an optically-pumped vertical external-cavity surface-emitting laser (VECSEL) at 1030 nm was characterized without standard f-to-2f interferometry. Instead, we used an appropriate combination of signals obtained from the modelocked oscillator and an auxiliary continuous-wave laser to extract information about the CEO signal. The estimated linewidth of the free-running CEO beat is approximately 1...
July 15, 2016: Optics Letters
https://www.readbyqxmd.com/read/27334266/esophageal-and-transpulmonary-pressure-in-the-clinical-setting-meaning-usefulness-and-perspectives
#16
REVIEW
Tommaso Mauri, Takeshi Yoshida, Giacomo Bellani, Ewan C Goligher, Guillaume Carteaux, Nuttapol Rittayamai, Francesco Mojoli, Davide Chiumello, Lise Piquilloud, Salvatore Grasso, Amal Jubran, Franco Laghi, Sheldon Magder, Antonio Pesenti, Stephen Loring, Luciano Gattinoni, Daniel Talmor, Lluis Blanch, Marcelo Amato, Lu Chen, Laurent Brochard, Jordi Mancebo
PURPOSE: Esophageal pressure (Pes) is a minimally invasive advanced respiratory monitoring method with the potential to guide management of ventilation support and enhance specific diagnoses in acute respiratory failure patients. To date, the use of Pes in the clinical setting is limited, and it is often seen as a research tool only. METHODS: This is a review of the relevant technical, physiological and clinical details that support the clinical utility of Pes. RESULTS: After appropriately positioning of the esophageal balloon, Pes monitoring allows titration of controlled and assisted mechanical ventilation to achieve personalized protective settings and the desired level of patient effort from the acute phase through to weaning...
September 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/27316915/french-intensive-care-society-international-congress-r%C3%A3-animation-2016
#17
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27310484/coexistence-and-impact-of-limb-muscle-and-diaphragm-weakness-at-time-of-liberation-from-mechanical-ventilation-in-medical-icu-patients
#18
Martin Dres, Bruno-Pierre Dubé, Julien Mayaux, Julie Delemazure, Danielle Reuter, Laurent Brochard, Thomas Similowski, Alexandre Demoule
BACKGROUND: Intensive care unit (ICU) and mechanical ventilation (MV) acquired limb muscle and diaphragm dysfunction may both be associated with longer length of stay and worse outcome. Whether they are two aspects of the same entity or whether they have a different prevalence and prognostic impact remains unclear. This study was designed to quantify the prevalence and coexistence of these two forms of ICU-acquired weakness and their impact on outcome. METHODS: In patients undergoing a first spontaneous breathing trial (SBT) after at least 24 h of MV, diaphragm dysfunction was evaluated using twitch tracheal pressure in response to bilateral anterior magnetic phrenic nerve stimulation (a pressure <11 cmH2O defined dysfunction) and ultrasonography (thickening fraction (TFdi) and excursion)...
June 16, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27245914/effect-of-non-invasive-oxygenation-strategies-in-immunocompromised-patients-with-severe-acute-respiratory-failure-a-post-hoc-analysis-of-a-randomised-trial
#19
Jean-Pierre Frat, Stéphanie Ragot, Christophe Girault, Sébastien Perbet, Gwénael Prat, Thierry Boulain, Alexandre Demoule, Jean-Damien Ricard, Rémi Coudroy, René Robert, Alain Mercat, Laurent Brochard, Arnaud W Thille
BACKGROUND: The use of non-invasive ventilation is controversial in immunocompromised patients with acute respiratory failure, whereas the use of high-flow nasal cannula oxygen therapy is growing as an alternative to standard oxygen. We aimed to compare outcomes of immunocompromised patients with acute respiratory failure treated with standard oxygen with those treated with high-flow nasal cannula oxygen alone or high-flow nasal cannula oxygen associated with non-invasive ventilation...
August 2016: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/27216909/a-review-of-the-ultrasound-assessment-of-diaphragmatic-function-in-clinical-practice
#20
Giuseppe Francesco Sferrazza Papa, Giulia Michela Pellegrino, Fabiano Di Marco, Gianluca Imeri, Laurent Brochard, Ewan Goligher, Stefano Centanni
Ultrasonography is the only non-invasive, non-ionizing imaging technique widely available to directly assess diaphragmatic function. Two different sonographic approaches permit the assessment of muscle thickening in the zone of apposition and excursion of the dome of the diaphragm. Thanks to the new hand-held ultrasound instruments, the morphology and function of the diaphragm can be assessed in different settings, such as outpatient clinic, pulmonary function test laboratory, hospital department and intensive care unit, and under different conditions...
2016: Respiration; International Review of Thoracic Diseases
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