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https://www.readbyqxmd.com/read/28110071/living-nano-micro-fibrous-woven-fabric-hydrogel-composite-scaffolds-for-heart-valve-engineering
#1
Shaohua Wu, Bin Duan, Xiaohong Qin, Jonathan T Butcher
: Regeneration and repair of injured or diseased heart valves remains a clinical challenge. Tissue engineering provides a promising treatment approach to facilitate living heart valve repair and regeneration. Three-dimensional (3D) biomimetic scaffolds that possess heterogeneous and anisotropic features that approximate those of native heart valve tissue are beneficial to the successful in vitro development of tissue engineered heart valves (TEHV). Here we report the development and characterization of a novel composite scaffold consisting of nano- and micro-scale fibrous woven fabrics and 3D hydrogels by using textile techniques combined with bioactive hydrogel formation...
January 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28109557/does-cutting-a-plaster-window-weaken-its-strength
#2
Nimesh Patel, Lance Wilson, Guy Wansbrough
INTRODUCTION: A plaster window is usually created over a pressure area, or in some cases a wound or suture line. This can relieve pressure at the site, and provide an opportunity to change dressings, check on drainage, and inspect a wound or ulcer. There is concern that this can have an effect on its function to provide fracture stability, and weakens the plaster. The biomechanical effects of windowing on plaster strength were therefore investigated, as it has not previously been reported...
January 16, 2017: Injury
https://www.readbyqxmd.com/read/28108403/risk-of-cement-leakage-and-pulmonary-embolism-by-bone-cement-augmented-pedicle-screw-fixation-of-the-thoracolumbar-spine
#3
Insa Janssen, Yu-Mi Ryang, Jens Gempt, Stefanie Bette, Julia Gerhardt, Jan Kirschke, Bernhard Meyer
BACKGROUND: Cement augmented pedicle screw instrumentation (CAPSI) of the thoracolumbar spine is indicated in osteoporosis or osteopenia to improve pullout strength and biomechanical stability of pedicle screws (PS). Only few studies report on the incidence of pulmonary cement embolism or other complications associated with CAPSI. PURPOSE: Aim of this retrospective study was to assess the rate of CAPSI associated complications. STUDY DESIGN: Retrospective cohort study...
January 17, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28106071/development-of-an-efficient-screening-system-to-identify-novel-bone-metabolism-related-genes-using-the-exchangeable-gene-trap-mutagenesis-mouse-models
#4
Syuji Kurogi, Tomohisa Sekimoto, Taro Funamoto, Tomomi Ota, Shihoko Nakamura, Takuya Nagai, Mai Nakahara, Kumiko Yoshinobu, Kimi Araki, Masatake Araki, Etsuo Chosa
Despite numerous genetic studies on bone metabolism, understanding of the specific mechanisms is lacking. We developed an efficient screening system to identify novel genes involved in bone metabolism using mutant mouse strains registered with the Exchangeable Gene Trap Clones (EGTC) database. From 1278 trap clones in the EGTC database, 52 candidate lines were selected in the first screening, determined based on "EST profile", "X-gal", "Related article", and "Novel gene". For the second screening, bone morphometric analysis, biomechanical strength analysis, bone X-gal staining, etc...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28104260/robot-guided-ankle-sensorimotor-rehabilitation-of-patients-with-multiple-sclerosis
#5
Yunju Lee, Kai Chen, Yupeng Ren, Jongsang Son, Bruce A Cohen, James A Sliwa, Li-Qun Zhang
BACKGROUND: People with multiple sclerosis (MS) often develop symptoms including muscle weakness, spasticity, imbalance, and sensory loss in the lower limbs, especially at the ankle, which result in impaired balance and locomotion and increased risk of falls. Rehabilitation strategies that improve ankle function may improve mobility and safety of ambulation in patients with MS. This pilot study investigated effectiveness of a robot-guided ankle passive-active movement training in reducing motor and sensory impairments and improving balance and gait functions...
January 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28103859/treatment-with-soluble-activin-type-iib-receptor-improves-bone-mass-and-strength-in-a-mouse-model-of-duchenne-muscular-dystrophy
#6
Tero Puolakkainen, Hongqian Ma, Heikki Kainulainen, Arja Pasternack, Timo Rantalainen, Olli Ritvos, Kristiina Heikinheimo, Juha J Hulmi, Riku Kiviranta
BACKGROUND: Inhibition of activin/myostatin pathway has emerged as a novel approach to increase muscle mass and bone strength. Duchenne muscular dystrophy (DMD) is a neuromuscular disorder that leads to progressive muscle degeneration and also high incidence of fractures. The aim of our study was to test whether inhibition of activin receptor IIB ligands with or without exercise could improve bone strength in the mdx mouse model for DMD. METHODS: Thirty-two mdx mice were divided to running and non-running groups and to receive either PBS control or soluble activin type IIB-receptor (ActRIIB-Fc) once weekly for 7 weeks...
January 19, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28100817/mechanical-sensitivity-and-the-dynamics-of-evolutionary-rate-shifts-in-biomechanical-systems
#7
Martha M Muñoz, Philip S L Anderson, S N Patek
The influence of biophysical relationships on rates of morphological evolution is a cornerstone of evolutionary theory. Mechanical sensitivity-the correlation strength between mechanical output and the system's underlying morphological components-is thought to impact the evolutionary dynamics of form-function relationships, yet has rarely been examined. Here, we compare the evolutionary rates of the mechanical components of the four-bar linkage system in the raptorial appendage of mantis shrimp (Order Stomatopoda)...
January 25, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28099193/the-effect-of-peripheral-nerve-stimulation-on-shoulder-biomechanics-a-randomized-controlled-trial-in-comparison-to-physical-therapy
#8
Richard D Wilson, Jayme S Knutson, Maria E Bennett, John Chae
OBJECTIVE: To establish the effects on shoulder biomechanics from a peripheral nerve stimulation (PNS) treatment compared to physical therapy (PT) in stroke survivors with chronic hemiplegic shoulder pain. DESIGN: Single-site, pilot, randomized controlled trial for adults with chronic shoulder pain after stroke. Participants were randomized to receive a 3-week treatment of single-lead PNS or physical therapy (PT). The outcomes included isometric shoulder abduction strength, pain-free shoulder external rotation range of motion (ROM), delay in initiation and termination of shoulder abduction electromyogram (EMG) activity, and the Fugl-Meyer Motor Assessment (upper extremity section)...
January 17, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28095516/effect-of-nanofeatured-topography-on-ceria-stabilized-zirconia-alumina-nanocomposite-on-osteogenesis-and-osseointegration
#9
Yoko Oshima, Fuminori Iwasa, Keita Tachi, Kazuyoshi Baba
PURPOSE: The objective of this study was to evaluate the osteogenic and osseointegration capability of the Ce-tetragonal zirconia polycrystal (TZP)-based nanostructured zirconia/alumina composite (Ce-TZP/Al₂O₃) that was treated with hydrofluoric acid (HF). MATERIALS AND METHODS: Osteogenic MC3T3-E1 cells were cultured on acid-etched titanium (AETi) disks and Ce-TZP/Al₂O₃ disks without HF treatment (Zr[0%]), with 4% HF treatment (Zr[4%]), or with 55% HF treatment (Zr[55%]) for 24 hours, and biologic responses were compared among four conditions in vitro...
January 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28095515/effects-of-ultraviolet-photofunctionalization-on-bone-augmentation-and-integration-capabilities-of-titanium-mesh-and-implants
#10
Makoto Hirota, Takayuki Ikeda, Masako Tabuchi, Tomomichi Ozawa, Iwai Tohnai, Takahiro Ogawa
PURPOSE: Ultraviolet (UV)-mediated photofunctionalization has earned considerable attention for the enhancement of the biologic capabilities of titanium. The effects of photofunctionalization on bone augmentation and gap closure were examined using titanium implants and mesh in a rat femur model. MATERIALS AND METHODS: An acid-etched titanium implant (4-mm length, 1-mm diameter) was placed in the gluteal tuberosity that resembles a knife-edge-like edentulous ridge...
January 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28095094/female-age-related-differences-in-biomechanics-and-muscle-activity-during-descents-on-the-outstretched-arms
#11
Lauren Jane Lattimer, Joel Lanovaz, Jon Farthing, Stéphanie Madill, Soo Kim, Stephen Robinovitch, Cathy Arnold
The purposes of this study were to examine female age differences in: 1) upper extremity (UE) and trunk muscle activity, elbow joint moment, loading force and UE energy absorption during a controlled forward body descent and 2) UE muscle strength. Twenty young (mean 24.8±3.4 yrs.) and 20 older (68.4±5.7 yrs.) women were assessed via dynamometry for isometric, concentric and eccentric UE strength and performed forward descents on force plates at three body lean angles (60, 45, and 30° from horizontal). Significant differences (p < ...
January 17, 2017: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/28093375/biomechanical-strength-and-failure-mechanism-of-different-tubercula-refixation-methods-within-the-framework-of-an-arthroplasty-for-shoulder-fracture
#12
Jörg Fleischer, Alexandra Schleyer, Roman Nassutt, Ulrike Grittner, Ishaq Ojodu, Sascha Jörg Hopp
BACKGROUND: Tuberosity repair in shoulder fracture prosthesis implantation still remains a challenge often leading to poor functional outcomes, despite a variety of materials and suggested suture patterns. We aimed to evaluate, which forces currently used suture and cerclage materials withstand and to assess whether they are useful with regard to stability of reconstruction of tuberosities and which failure modes they display. MATERIAL AND METHODS: Using sheep infraspinatus tendons with attached tuberosities three different suture materials (suture 1: Ethibond size 2; suture 2: Orthocord size 2; suture 3: Fiberwire size 5) and a 0...
January 13, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28092968/effect-of-suture-caliber-and-number-of-core-strands-on-repair-of-acute-achilles-ruptures
#13
Jonathon D Backus, Daniel Cole Marchetti, Erik L Slette, Kimi D Dahl, Travis Lee Turnbull, Thomas O Clanton
BACKGROUND: Controversy exists regarding the ideal Achilles rupture treatment; however, operative treatment is considered for athletes and active patients. The ideal repair construct is evolving, and the effect of suture caliber or number of core strands has not been studied. METHODS: Simulated mid-substance Achilles ruptures were performed in 24 cadavers. Specimens were randomized to three 6-core-strand style repair constructs: (1) 4 No. 2 sutures and two 2-mm tapes (2T); (2) 2 No...
January 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28090744/effects-of-different-hierarchical-hybrid-micro-nanostructure-surfaces-on-implant-osseointegration
#14
Bingkun Cheng, Qiang Niu, Yajun Cui, Wei Jiang, Yunzhuan Zhao, Liang Kong
BACKGROUND: Hierarchical hybrid micro/nanostructure implant surfaces are considered to better mimic the hierarchical structure of bone and the nanostructures substantively influence osseointegration through managing cell behaviors. PURPOSE: To enhance implant osseointegration for further clinical application, we evaluated the material properties and osseointegration effects of hierarchical surfaces with different nano-morphologies, using a rat model. MATERIALS AND METHODS: Two representative surface fabrication methods, hydrofluoric (HF) acid etching combined with anodization (HF + AN) or magnetron sputtering (HF + MS), were selected...
January 15, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28089826/comparison-of-histologic-healing-and-biomechanical-characteristics-between-repair-techniques-for-a-delaminated-rotator-cuff-tear-in-rabbits
#15
Sang-Jin Cheon, Jung-Han Kim, Heui-Chul Gwak, Chang-Wan Kim, Jeon-Kyo Kim, Ji-Hwan Park
BACKGROUND: The purpose of this study was to compare histologic healing and biomechanical characteristics between 2 repair techniques (layer by layer, repair of each layer to bone separately; and whole layer, repair of each layer to the bone en masse) for delaminated rotator cuff tear. MATERIALS AND METHODS: Rabbits were used as subjects and classified into 2 groups: group A, right side, the layer-by-layer repair group; and group B, left side, the whole-layer repair group...
January 12, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28089497/biomechanical-comparison-of-standard-and-linked-single-row-rotator-cuff-repairs-in-a-human-cadaver-model
#16
Adam F Meisel, Heath B Henninger, F Alan Barber, Mark H Getelman
PURPOSE: The purpose of this study was to evaluate the time zero cyclic and failure loading properties of a linked single-row rotator cuff repair compared with a standard simple suture single-row repair using triple-loaded suture anchors. METHODS: Eighteen human cadaveric shoulders from 9 matched pairs were dissected, and full-thickness supraspinatus tears were created. The tendon cross-sectional area was recorded. In each pair, one side was repaired with a linked single-row construct and the other with a simple suture single-row construct, both using 2 triple-loaded suture anchors...
January 12, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28069517/fast-estimation-of-colles-fracture-load-of-the-distal-section-of-the-radius-by-homogenized-finite-element-analysis-based-on-hr-pqct
#17
Hadi S Hosseini, Andreas Dünki, Jonas Fabech, Martin Stauber, Nicolas Vilayphiou, Dieter Pahr, Michael Pretterklieber, Jasmin Wandel, Bert van Rietbergen, Philippe K Zysset
Fractures of the distal section of the radius (Colles' fractures) occur earlier in life than other osteoporotic fractures. Therefore, they can be interpreted as a warning signal for later, more deleterious fractures of vertebral bodies or the femoral neck. In the past decade, the advent of HR-pQCT allowed a detailed architectural analysis of the distal radius and an automated but time-consuming estimation of its strength with linear micro-finite element (μFE) analysis. Recently, a second generation of HR-pQCT scanner (XtremeCT II, SCANCO Medical, Switzerland) with a resolution beyond 61 μm became available for even more refined biomechanical investigations in vivo...
January 7, 2017: Bone
https://www.readbyqxmd.com/read/28067614/experimental-determination-of-rupture-pressure-and-stress-of-adventitia-of-human-middle-cerebral-arteries
#18
Adam Piechna, Leszek Lombarski, Bogdan Ciszek, Krzysztof Cieslicki
Background Intracranial arterial dissections might be attributed to the particular biomechanical properties of their specific layers. Also, knowledge of adventitia properties would be crucial in the context of intracranial balloon angioplasty. Aims The purpose of this work was to determine the rupture pressure of separated adventitia and compare it to intact cerebral arterial segments. Methods Brain specimens were harvested from 14 autopsy subjects (age range from 23 to 86 years). Pressure-inflation tests were conducted on proximal segments of middle cerebral arteries and separated adventitia layers from contralateral arteries to assess the rupture pressure values...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28066520/gait-training-interventions-for-lower-extremity-amputees-a-systematic-literature-review
#19
M Jason Highsmith, Casey R Andrews, Claire Millman, Ashley Fuller, Jason T Kahle, Tyler D Klenow, Katherine L Lewis, Rachel C Bradley, John J Orriola
Lower extremity (LE) amputation patients who use prostheses have gait asymmetries and altered limb loading and movement strategies when ambulating. Subsequent secondary conditions are believed to be associated with gait deviations and lead to long-term complications that impact function and quality of life as a result. The purpose of this study was to systematically review the literature to determine the strength of evidence supporting gait training interventions and to formulate evidence statements to guide practice and research related to therapeutic gait training for lower extremity amputees...
September 2016: Technology and Innovation
https://www.readbyqxmd.com/read/28057631/ultimate-fracture-load-of-cadaver-proximal-humeri-correlates-more-strongly-with-mean-combined-cortical-thickness-than-with-areal-cortical-index-dexa-density-or-canal-to-calcar-ratio
#20
J G Skedros, C S Mears, W Z Burkhead
OBJECTIVES: This investigation sought to advance the work published in our prior biomechanical study (Journal of Orthopaedic Research, 2016). We specifically sought to determine whether there are additional easy-to-measure parameters on plain radiographs of the proximal humerus that correlate more strongly with ultimate fracture load, and whether a parameter resembling the Dorr strength/quality characterisation of proximal femurs can be applied to humeri. MATERIALS AND METHODS: A total of 33 adult humeri were used from a previous study where we quantified bone mineral density of the proximal humerus using radiographs and dual-energy x-ray absorptiometry (DEXA), and regional mean cortical thickness and cortical index using radiographs...
January 2017: Bone & Joint Research
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