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https://www.readbyqxmd.com/read/29675269/translation-of-remote-control-regenerative-technologies-for-bone-repair
#1
Hareklea Markides, Jane S McLaren, Neil D Telling, Noura Alom, E'atelaf A Al-Mutheffer, Richard O C Oreffo, Andrew Zannettino, Brigitte E Scammell, Lisa J White, Alicia J El Haj
The role of biomechanical stimuli, or mechanotransduction, in normal bone homeostasis and repair is understood to facilitate effective osteogenesis of mesenchymal stem cells (MSCs) in vitro. Mechanotransduction has been integrated into a multitude of in vitro bone tissue engineering strategies and provides an effective means of controlling cell behaviour towards therapeutic outcomes. However, the delivery of mechanical stimuli to exogenous MSC populations, post implantation, poses a significant translational hurdle...
2018: NPJ Regenerative Medicine
https://www.readbyqxmd.com/read/29666653/mesenchymal-stem-cells-in-oriented-plga-acecm-composite-scaffolds-enhance-structure-specific-regeneration-of-hyaline-cartilage-in-a-rabbit-model
#2
Weimin Guo, Xifu Zheng, Weiguo Zhang, Mingxue Chen, Zhenyong Wang, Chunxiang Hao, Jingxiang Huang, Zhiguo Yuan, Yu Zhang, Mingjie Wang, Jiang Peng, Aiyuan Wang, Yu Wang, Xiang Sui, Wenjing Xu, Shuyun Liu, Shibi Lu, Quanyi Guo
Articular cartilage lacks a blood supply and nerves. Hence, articular cartilage regeneration remains a major challenge in orthopedics. Decellularized extracellular matrix- (ECM-) based strategies have recently received particular attention. The structure of native cartilage exhibits complex zonal heterogeneity. Specifically, the development of a tissue-engineered scaffold mimicking the aligned structure of native cartilage would be of great utility in terms of cartilage regeneration. Previously, we fabricated oriented PLGA/ACECM (natural, nanofibrous, articular cartilage ECM) composite scaffolds...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29665068/osteoporosis-and-hip-fracture-risk-from-routine-computed-tomography-scans-the-fracture-osteoporosis-and-ct-utilization-study-focus
#3
Annette L Adams, Heidi Fischer, David L Kopperdahl, David C Lee, Dennis M Black, Mary L Bouxsein, Shireen Fatemi, Sundeep Khosla, Eric S Orwoll, Ethel S Siris, Tony M Keaveny
Methods now exist for analyzing previously taken clinical computed tomography (CT) scans to measure a dual-energy X-ray absorptiometry (DXA)-equivalent bone mineral density (BMD) at the hip and a finite element analysis-derived femoral strength. We assessed the efficacy of this "biomechanical CT" (BCT) approach for identifying patients at high risk of incident hip fracture in a large clinical setting. Using a case-cohort design sampled from 111,694 women and men aged 65 or older who had a prior hip CT scan, a DXA within 3 years of the CT, and no prior hip fracture, we compared those with subsequent hip fracture (n = 1959) with randomly selected sex-stratified controls (n = 1979) and analyzed their CT scans blinded to all other data...
April 17, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29664955/efficacy-of-a-biomechanically-based-yoga-exercise-program-in-knee-osteoarthritis-a-randomized-controlled-trial
#4
Alexander B Kuntz, Jaclyn N Chopp-Hurley, Elora C Brenneman, Sarah Karampatos, Emily G Wiebenga, Jonathan D Adachi, Michael D Noseworthy, Monica R Maly
OBJECTIVE: Certain exercises could overload the osteoarthritic knee. We developed an exercise program from yoga postures with a minimal knee adduction moment for knee osteoarthritis. The purpose was to compare the effectiveness of this biomechanically-based yoga exercise (YE), with traditional exercise (TE), and a no-exercise attention-equivalent control (NE) for improving pain, self-reported physical function and mobility performance in women with knee osteoarthritis. DESIGN: Single-blind, three-arm randomized controlled trial...
2018: PloS One
https://www.readbyqxmd.com/read/29662756/effect-of-capsaicin-sensitive-sensory-neurons-on-bone-architecture-and-mechanical-properties-in-the-rat-hindlimb-suspension-model
#5
Zong-Kang Zhang, Xia Guo, Jie Lao, Yi-Xian Qin
Background/Objective: The participation of sensory neural regulation in bone metabolism has been widely studied. However, the physiological role of sensory neural regulation in the functional adaptation to weight bearing is not clear. This study was conducted to investigate the effect of capsaicin-induced sensory neuron lesions on cancellous architecture properties in a hindlimb suspension (HLS) model. Methods: Thirty-two female rats were randomly assigned to four groups...
July 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29658661/-biomechanical-and-biocompatible-enhancement-of-reinforced-calcium-phosphate-cement-via-rgd-peptide-grafted-chitosan-nanofibers
#6
Yang Huang, Jinsong Kong, Xiaokang Gong, Xin Zheng, Haibao Wang, Jianwei Ruan
<b>Objective:</b> To analysis the biomechanical and biocompatible properties of calcium phosphate cement (CPC) enhanced by chitosan short nanofibers(CSNF) and Arg-Gly-Asp (RGD). <b>Methods:</b> Chitosan nanofibers were prepared by electrospinning, and cut into short fibers by high speed dispersion. CPC with calcium phosphorus ratio of 1.5:1 was prepared by Biocement D method. The composition and structure of CPC, CSNF, RGD modified CSNF (CSNF-RGD), CSNF enhanced CPC (CPC-CSNF), RGD modified CPC-CSNF (CPC-CSNF-RGD) were observed by infrared spectrum, X-ray diffraction (XRD) and scan electron microscopy (SEM)...
May 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/29658659/-effect-of-resveratrol-on-peak-bone-mass-in-growing-rats
#7
Huirong Xi, Yuhai Gao, Fangfang Yang, Wenyuan Li, Huiping Ma, Keming Chen
<b>Objective:</b> To investigate the effect of resveratrol on peak bone mineral density and bone mass in growing rats. <b>Methods:</b> Thirty-six female healthy Wistar rats were randomly divided into control group, icariin group and resveratrol group with 12 rats in each group. Icariin (25 mg·kg<sup>-1</sup>·d<sup>-1</sup>), resveratrol (8.4 mg·kg<sup>-1</sup>·d<sup>-1</sup>) or equal volume of distilled water were given by gavage to icariin group, resveratrol group and control group, respectively...
May 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/29658519/biomechanical-evaluation-of-tendon-connection-with-novel-suture-techniques
#8
Zhe Chen, Jun Wang, Jia-Sen Wei, Zhao-Yang Hou, Min Li, Qi-Xin Chen
PURPOSE: Achilles tendon rupture is a severe injury with poor curative effect due to its anatomical characteristic and mechanical peculiarity. Internal fixation of limited loop (IFLL) with steel-wire has been applied on patients with tendon rupture to fix the broken ends before physical rehabilitation. The purpose of this study is to investigate the biomechanical property and radiological characteristic of such suture technique for the repairment of tendon rupture. METHODS: Tendons of pigs' hint feet were separated for the biomechanical study...
2018: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/29658148/biochemical-and-biomechanical-characterization-of-equine-cervical-facet-joint-cartilage
#9
S A O'Leary, J L White, J C Hu, K A Athanasiou
BACKGROUND: The equine cervical facet joint is a site of significant pathology. Located bilaterally on the dorsal spine, these diarthrodial joints work in conjunction with the intervertebral disc to facilitate appropriate spinal motion. Despite the high prevalence of pathology in this joint, the facet joint is understudied and thus lacking in viable treatment options. OBJECTIVE: The goal of this study was to characterise equine facet joint cartilage and provide a comprehensive database describing the morphological, histological, biochemical, and biomechanical properties of this tissue...
April 15, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29657842/repair-of-syndesmosis-injury-in-ankle-fractures-current-state-of-the-art
#10
May Fong Mak, Richard Stern, Mathieu Assal
Conventional treatment of syndesmosis injuries in rotationally unstable ankle fractures is associated with an unacceptably high rate of malreduction, and this has led to a paradigm shift in the approach to a newer concept of anatomical repair.In the anatomical approach, the principle is to 'directly fix what is broken and repair what is torn'. The approach is effective in reducing the rate of syndesmosis malreduction, increasing the biomechanical strength of syndesmosis fixation and avoiding the need for trans-syndesmotic fixation and its secondary removal...
January 2018: EFORT Open Reviews
https://www.readbyqxmd.com/read/29657450/current-advances-in-the-treatment-of-medial-and-lateral-epicondylitis
#11
REVIEW
Sandip P Tarpada, Matthew T Morris, Jayson Lian, Sina Rashidi
Despite advances elucidating the causes of lateral and medial epicondylitis, the standard of care remains conservative management with NSAIDs, physical therapy, bracing, and rest. Scar tissue formation provoked by conservative management creates a tendon lacking the biomechanical properties and mechanical strength of normal tendon. The following review analyzes novel therapies to regenerate tendon and regain function in patients with epicondylitis. These treatments include PRP injection, BMAC, collagen-producing cell injection, and stem cell treatments...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29657449/analysis-of-glenoid-inter-anchor-distance-with-an-all-suture-anchor-system
#12
Jonathan D Kramer, Sean Robinson, Connor Purviance, William Montgomery
Background: All-suture anchors used in arthroscopic shoulder stabilization employ small diameter anchors, which allow greater placement density on narrow surfaces such as the glenoid. There is no consensus in the literature about how close to one another two anchors may be implanted. Purpose: The purpose of the present study is to compare the strength characteristics of two all-suture anchors placed in cadaveric human glenoid at variable distances to one another, in order to determine the minimum distance required for optimal strength...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29652192/achilles-pullout-strength-after-open-calcaneoplasty-for-haglund-syndrome
#13
Glenn Pfeffer, Tyler Gonzalez, Matthew Zapf, Trevor J Nelson, Melodie F Metzger
BACKGROUND: Haglund syndrome involves a prominent posterior superior prominence of the calcaneus. If nonoperative management fails, operative management with calcaneoplasty is often needed. No study has assessed Achilles tendon pullout strength after an open calcaneoplasty for Haglund syndrome. The purpose of this study was to investigate those changes in a cadaveric model and provide objective data upon which to base postoperative recovery. METHODS: Seven matched pairs of cadaveric specimens (mid-tibia to toes) were divided into 2 cohorts: (1) intact/untreated and (2) open resection...
April 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29649957/tissue-engineered-neo-urinary-conduit-from-decellularized-trachea
#14
Anirudha Anirudhasingh Gmail Com Singh, David Lee, Harrison Jeong, Christine Yu, Jiuru Li, ChenHao Fang, Praveena Sabnekar, Xiaopu Liu, Takahiro Yoshida, Nikolai Sopko, Trinity Bivalacqua
Decellularized tissues have been increasingly popular for constructing scaffolds for tissue engineering applications due to their beneficial biological compositions and mechanical properties. It is therefore natural to consider decellularized trachea for construction of tissue-engineered trachea as well as other tubular organs. A neo-urinary conduit (NUC) is such a tubular organ that works as a passage for urine removal in bladder cancer patients who need a urinary diversion after their diseased bladder is removed...
April 13, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29649498/the-wakefulness-promoting-drug-modafinil-causes-adenosine-receptor-mediated-upregulation-of-receptor-activator-of-nuclear-factor-%C3%AE%C2%BAb-ligand-in-osteoblasts-negative-impact-of-the-drug-on-peak-bone-accrual-in-rats
#15
Shyamsundar Pal China, Subhashis Pal, Sourav Chattopadhyay, Konica Porwal, Monika Mittal, Sabyasachi Sanyal, Naibedya Chattopadhyay
Modafinil is primarily prescribed for treatment of narcolepsy and other sleep-associated disorders. However, its off-prescription use as a cognition enhancer increased considerably, specially among youths. Given its increasing use in young adults the effect of modafinil on peak bone accrual is an important issue but has never been investigated. Modafinil treatment to young male rats caused trabecular and cortical bone loss in tibia and femur, and reduction in biomechanical strength. Co-treatment of modafinil with alendronate (a drug that suppresses bone resorption) reversed the trabecular bone loss but failed to prevent cortical loss...
April 9, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29623650/multi-scale-approach-for-the-evaluation-of-bone-mineralization-in-strontium-ranelate-treated-diabetic-rats
#16
Pedro Álvarez-Lloret, Juan Manuel Fernández, María Silvina Molinuevo, Agustina Berenice Lino, José Luis Ferretti, Ricardo Francisco Capozza, Ana María Cortizo, Antonio Desmond McCarthy
Long-term diabetes mellitus can induce osteopenia and osteoporosis, an increase in the incidence of low-stress fractures, and/or delayed fracture healing. Strontium ranelate (SrR) is a dual-action anti-osteoporotic agent whose use in individuals with diabetic osteopathy has not been adequately evaluated. In this study, we studied the effects of an oral treatment with SrR and/or experimental diabetes on bone composition and biomechanics. Young male Wistar rats (half non-diabetic, half with streptozotocin/nicotinamide-induced diabetes) were either untreated or orally administered 625 mg/kg/day of SrR for 6 weeks...
April 5, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29623537/glutaraldehyde-cross-linking-modification-of-decellularized-rat-kidney-scaffolds
#17
Yaling Yu, Li Liu, Jianse Zhang, Zairong Wei, Jin Mei
The decellularized (DC) scaffolds retain three-dimensional structures for the stimulation of cell growth, with components of the extracellular matrix (ECM) relatively conserved between species. The strategy based on decellularized scaffolds provides a new way for organ regeneration, with a number of prominent advances having been reported in the past few years. While their lack of biomechanical strength and excessive degradation limit the clinical applications, therefore it is urgent to modify the DC scaffolds to improve the performance...
April 6, 2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29620913/into-tunnel-repair-versus-onto-surface-repair-for-rotator-cuff-tears-in-a-rabbit-model
#18
Xiaoxi Li, Peng Shen, Wei Su, Song Zhao, Jinzhong Zhao
BACKGROUND: Clinically, onto-surface repair is commonly used for rotator cuff tears. The retear rate after rotator cuff repair (RCR) is relatively high, with failure occurring mostly at the tendon-bone connection site. For anterior cruciate ligament (ACL) reconstruction, into-tunnel reconstruction is commonly employed. The retear rate after ACL reconstruction is relatively low, with retears seldom occurring at the tendon-bone interface. No study on into-tunnel RCR has been conducted. HYPOTHESIS: Into-tunnel RCR could promote fibrocartilage regeneration at the tendon-bone interface and has biomechanical advantage over onto-surface repair in a rabbit rotator cuff tear model...
April 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29619886/assessment-of-conduit-assisted-primary-nerve-repair-strength-with-varying-suture-size-number-and-location
#19
Nikola Babovic, Derek Klaus, Matthew J Schessler, Patrick J Schimoler, Alexander Kharlamov, Mark C Miller, Peter Tang
BACKGROUND: Outcomes following digital nerve repair are suboptimal despite much research and various methods of repair. Increased tensile strength of the repair and decreased suture material at the repair site may be 2 methods of improving biologic and biomechanical outcomes, and conduit-assisted repair can aid in achieving both of these goals. METHODS: Ninety-nine fresh-frozen digital nerves were equally divided into 11 different groups. Each group uses a different combination of number of sutures at the coaptation site and number of sutures at each end of the nerve-conduit junction, as well as 2 calibers of nylon suture...
April 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29618611/fam210a-is-a-novel-determinant-of-bone-and-muscle-structure-and-strength
#20
Ken-Ichiro Tanaka, Yingben Xue, Loan Nguyen-Yamamoto, John A Morris, Ippei Kanazawa, Toshitsugu Sugimoto, Simon S Wing, J Brent Richards, David Goltzman
Osteoporosis and sarcopenia are common comorbid diseases, yet their shared mechanisms are largely unknown. We found that genetic variation near FAM210A was associated, through large genome-wide association studies, with fracture, bone mineral density (BMD), and appendicular and whole body lean mass, in humans. In mice, Fam210a was expressed in muscle mitochondria and cytoplasm, as well as in heart and brain, but not in bone. Grip strength and limb lean mass were reduced in tamoxifen-inducible Fam210a homozygous global knockout mice ( TFam210a -/- ), and in tamoxifen-inducible Fam210 skeletal muscle cell-specific knockout mice ( TFam210aMus -/- )...
April 4, 2018: Proceedings of the National Academy of Sciences of the United States of America
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