Xiaowei Zhang, Zhenhua Zheng, Bo Shu, Xijuan Liu, Zhenfeng Zhang, Yan Liu, Bingke Bai, Qinxue Hu, Panyong Mao, Hanzhong Wang
Enteroviruses can frequently target the human central nervous system to induce a variety of neurological diseases. Although enteroviruses are highly cytolytic, emerging evidence has shown that these viruses can establish persistent infections both in vivo and in vitro. Here, we investigated the susceptibility of three human brain cell lines, CCF-STTG1, T98G, and SK-N-SH, to infection with three enterovirus serotypes: coxsackievirus B3 (CVB3), enterovirus 71, and coxsackievirus A9. Persistent infection was observed in CVB3-infected CCF-STTG1 cells, as evidenced by prolonged detection of infectious virions, viral RNA, and viral antigens...
November 2013: Journal of Virology