Wenshuang Wu, Jing Zhang, Yu Chen, Qianqian Chen, Qianyan Liu, Fuchao Zhang, Shiying Li, Xinghui Wang
This review explores the molecular and genetic underpinnings of axonal regeneration and functional recovery post-nerve injury, emphasizing its significance in reversing neurological deficits. It presents a systematic exploration of the roles of various genes in axonal regrowth across peripheral and central nerve injuries. Initially, it highlights genes and gene families critical for axonal growth and guidance, delving into their roles in regeneration. It then examines the regenerative microenvironment, focusing on the role of glial cells in neural repair through dedifferentiation, proliferation, and migration...
February 22, 2024: Molecular Neurobiology