keyword
https://read.qxmd.com/read/38460093/progranulin-facilitates-corneal-repair-through-dual-mechanisms-of-inflammation-suppression-and-regeneration-promotion
#21
JOURNAL ARTICLE
Dan Yan, Yunuo Zhang, Yuhan Huang, Weijie Ouyang
The cornea serves as a vital protective barrier for the eye; however, it is prone to injury and damage that can disrupt corneal epithelium and nerves, triggering inflammation. Therefore, understanding the biological effects and molecular mechanisms involved in corneal wound healing and identifying drugs targeting these pathways is crucial for researchers in this field. This study aimed to investigate the therapeutic potential of progranulin (PGRN) in treating corneal injuries. Our findings demonstrated that PGRN significantly enhanced corneal wound repair by accelerating corneal re-epithelialization and re-innervation...
March 9, 2024: Inflammation
https://read.qxmd.com/read/38448976/interleukin-4-from-curcumin-activated-oecs-emerges-as-a-central-modulator-for-increasing-m2-polarization-of-microglia-macrophage-in-oec-anti-inflammatory-activity-for-functional-repair-of-spinal-cord-injury
#22
JOURNAL ARTICLE
Jianbin Guo, Xiangwen Tang, Peng Deng, Hao Hui, Bo Chen, Jing An, Gaorong Zhang, Kuohao Shi, Jinchao Wang, Yuqing He, Dingjun Hao, Hao Yang
Microglia/macrophages are major contributors to neuroinflammation in the central nervous system (CNS) injury and exhibit either pro- or anti-inflammatory phenotypes in response to specific microenvironmental signals. Our latest in vivo and in vitro studies demonstrated that curcumin-treated olfactory ensheathing cells (aOECs) can effectively enhance neural survival and axonal outgrowth, and transplantation of aOECs improves the neurological outcome after spinal cord injury (SCI). The therapeutic effect is largely attributed to aOEC anti-inflammatory activity through the modulation of microglial polarization from the M1 to M2 phenotype...
March 6, 2024: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/38441922/postsynaptic-%C3%AE-1%C3%A2-spectrin-maintains-na-channels-at-the-neuromuscular-junction
#23
JOURNAL ARTICLE
Ozlem Sert, Xiaoyun Ding, Chuansheng Zhang, Ruifa Mi, Ahmet Hoke, Matthew N Rasband
Spectrins function together with actin as obligatory subunits of the submembranous cytoskeleton. Spectrins maintain cell shape, resist mechanical forces, and stabilize ion channel and transporter protein complexes through binding to scaffolding proteins. Recently, pathogenic variants of SPTBN4 (β4 spectrin) were reported to cause both neuropathy and myopathy. Although the role of β4 spectrin in neurons is mostly understood, its function in skeletal muscle, another excitable tissue subject to large forces, is unknown...
March 5, 2024: Journal of Physiology
https://read.qxmd.com/read/38427495/mono-and-biallelic-inactivation-of-huntingtin-gene-in-patient-specific-induced-pluripotent-stem-cells-reveal-htt-roles-in-striatal-development-and-neuronal-functions
#24
JOURNAL ARTICLE
Morgane Louessard, Michel Cailleret, Margot Jarrige, Julie Bigarreau, Sophie Lenoir, Noëlle Dufour, Maria Rey, Frédéric Saudou, Nicole Deglon, Anselme L Perrier
BACKGROUND: Mutations in the Huntingtin (HTT) gene cause Huntington's disease (HD), a neurodegenerative disorder. As a scaffold protein, HTT is involved in numerous cellular functions, but its normal and pathogenic functions during human forebrain development are poorly understood. OBJECTIVE: To investigate the developmental component of HD, with a specific emphasis on understanding the functions of wild-type and mutant HTT alleles during forebrain neuron development in individuals carrying HD mutations...
February 24, 2024: Journal of Huntington's Disease
https://read.qxmd.com/read/38421469/unravelling-the-road-to-recovery-mechanisms-of-wnt-signalling-in-spinal-cord-injury
#25
REVIEW
Suchita Ganesan, Arun Dharmarajan, G Sudhir, Lakshmi R Perumalsamy
Spinal cord injury (SCI) is a complex neurodegenerative pathology that consistently harbours a poor prognostic outcome. At present, there are few therapeutic strategies that can halt neuronal cell death and facilitate functional motor recovery. However, recent studies have highlighted the Wnt pathway as a key promoter of axon regeneration following central nervous system (CNS) injuries. Emerging evidence also suggests that the temporal dysregulation of Wnt may drive cell death post-SCI. A major challenge in SCI treatment resides in developing therapeutics that can effectively target inflammation and facilitate glial scar repair...
February 29, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38421133/serum-response-factor-promoting-axonal-regeneration-by-activating-the-ras-raf-cofilin-signaling-pathway-after-the-spinal-cord-injury
#26
JOURNAL ARTICLE
Limin Gao, Chen Zhang, Yonglin Zhu, Naili Zhang, Chunlei Zhang, Shuai Zhou, Guoying Feng, Fei Huang, Luping Zhang
INTRODUCTION: Serum response factor (SRF) is important in muscle development, tissue repair, and neuronal regulation. OBJECTIVES: This research aims to thoroughly examine the effects of SRF on spinal cord injury (SCI) and its ability to significantly impact the recovery and regeneration of neuronal axons. METHODS: The researchers created rat models of SCI and scratch injury to primary spinal cord neurons to observe the expression of relevant factors after neuronal injury...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38421080/emerging-roles-of-nerve-bone-axis-in-modulating-skeletal-system
#27
REVIEW
Jingya Li, Zhuoyuan Zhang, Jinru Tang, Zeyu Hou, Longjiang Li, Bo Li
Over the past decades, emerging evidence in the literature has demonstrated that the innervation of bone is a crucial modulator for skeletal physiology and pathophysiology. The nerve-bone axis sparked extensive preclinical and clinical investigations aimed at elucidating the contribution of nerve-bone crosstalks to skeleton metabolism, homeostasis, and injury repair through the perspective of skeletal neurobiology. To date, peripheral nerves have been widely reported to mediate bone growth and development and fracture healing via the secretion of neurotransmitters, neuropeptides, axon guidance factors, and neurotrophins...
February 29, 2024: Medicinal Research Reviews
https://read.qxmd.com/read/38414797/anisotropic-microtopography-surface-of-chitosan-scaffold-regulating-skin-precursor-derived-schwann-cells-towards-repair-phenotype-promotes-neural-regeneration
#28
JOURNAL ARTICLE
Meng Cong, Xia Wu, Lingjie Zhu, Guohao Gu, Fei Ding, Guicai Li, Haiyan Shi
For repairing peripheral nerve and spinal cord defects, biomaterial scaffold-based cell-therapy was emerged as an effective strategy, requiring the positive response of seed cells to biomaterial substrate and environment signals. Previous work highlighted that the imposed surface properties of scaffold could provide important guidance cues to adhered cells for polarization. However, the insufficiency of native Schwann cells and unclear cellular response mechanisms remained to be addressed. Given that, this study aimed to illuminate the micropatterned chitosan-film action on the rat skin precursor-derived Schwann cells (SKP-SCs)...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38411258/comparative-analysis-of-supercritical-fluid-based-and-chemical-based-decellularization-techniques-for-nerve-tissue-regeneration
#29
JOURNAL ARTICLE
Beom-Seok Kim, Jeong-Uk Kim, Jae Woo Lee, Kyung Min Ryu, Rachel H Koh, Kyoung-Ha So, Nathaniel S Hwang
Axon regeneration and Schwann cell proliferation are critical processes in the repair and functional recovery of damaged neural tissues. Biomaterials can play a crucial role in facilitating cell proliferative processes that can significantly impact the target tissue repair. Chemical decellularization and supercritical fluid-based decellularization methods are similar approaches that eliminate DNA from native tissues for tissue-mimetic biomaterial production by using different solvents and procedures to achieve the final products...
February 27, 2024: Biomaterials Science
https://read.qxmd.com/read/38408580/injectable-self-healing-hyaluronic-acid-based-hydrogels-for-spinal-cord-injury-repair
#30
JOURNAL ARTICLE
Penghui Fan, Shangzhi Li, Junfeng Yang, Kaidan Yang, Ping Wu, Qi Dong, Yingshan Zhou
The cystic cavity that develops following spinal cord injury is a major obstacle for repairing spinal cord injury (SCI). The injectable self-healing biomaterials treatment is a promising strategy to enhance tissue repair after traumatic spinal cord injury. Herein, a natural extracellular matrix (ECM) biopolymer hyaluronic acid-based hydrogel was developed based on multiple dynamic covalent bonds. The hydrogels exhibited excellent injectable and self-healing properties, could be effectively injected into the injury site, and filled the lesion cavity to accelerate the tissue repair of traumatic SCI...
February 24, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38397420/calcium-associated-proteins-in-neuroregeneration
#31
REVIEW
Malwina Lisek, Julia Tomczak, Tomasz Boczek, Ludmila Zylinska
The dysregulation of intracellular calcium levels is a critical factor in neurodegeneration, leading to the aberrant activation of calcium-dependent processes and, ultimately, cell death. Ca2+ signals vary in magnitude, duration, and the type of neuron affected. A moderate Ca2+ concentration can initiate certain cellular repair pathways and promote neuroregeneration. While the peripheral nervous system exhibits an intrinsic regenerative capability, the central nervous system has limited self-repair potential...
February 2, 2024: Biomolecules
https://read.qxmd.com/read/38396709/role-of-oxygen-and-its-radicals-in-peripheral-nerve-regeneration-from-hypoxia-to-physoxia-to-hyperoxia
#32
REVIEW
Dominik André-Lévigne, Rodrigue Pignel, Sylvain Boet, Vincent Jaquet, Daniel F Kalbermatten, Srinivas Madduri
Oxygen is compulsory for mitochondrial function and energy supply, but it has numerous more nuanced roles. The different roles of oxygen in peripheral nerve regeneration range from energy supply, inflammation, phagocytosis, and oxidative cell destruction in the context of reperfusion injury to crucial redox signaling cascades that are necessary for effective axonal outgrowth. A fine balance between reactive oxygen species production and antioxidant activity draws the line between physiological and pathological nerve regeneration...
February 7, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38390643/neuromuscular-ultrasound-changes-in-unilateral-symptomatic-subacute-lumbosacral-radiculopathy-a-prospective-simple-blinded-cohort-study
#33
JOURNAL ARTICLE
David Cuendet, Daniele Valsecchi, Hugo Najberg, Gianluca Maestretti, Friedrich Medlin
INTRODUCTION/AIMS: Lumbosacral radiculopathy (LR) is a common disorder. Neuromuscular ultrasound (NMU) is a rapidly evolving technique for the investigation of peripheral nerve and muscle disorders, but studies using NMU in LR are lacking. The aim of the present study was to investigate ultrasonographic neuromuscular changes distant from root compression in patients with subacute to chronic compressive LR with motor impairment. METHODS: Patients with unilateral subacute to chronic L4, L5, or S1 radiculopathy with motor impairment and confirmed by magnetic resonance imaging were included...
February 23, 2024: Muscle & Nerve
https://read.qxmd.com/read/38388774/genes-in-axonal-regeneration
#34
REVIEW
Wenshuang Wu, Jing Zhang, Yu Chen, Qianqian Chen, Qianyan Liu, Fuchao Zhang, Shiying Li, Xinghui Wang
This review explores the molecular and genetic underpinnings of axonal regeneration and functional recovery post-nerve injury, emphasizing its significance in reversing neurological deficits. It presents a systematic exploration of the roles of various genes in axonal regrowth across peripheral and central nerve injuries. Initially, it highlights genes and gene families critical for axonal growth and guidance, delving into their roles in regeneration. It then examines the regenerative microenvironment, focusing on the role of glial cells in neural repair through dedifferentiation, proliferation, and migration...
February 22, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38385458/contralesional-anodal-transcranial-direct-current-stimulation-promotes-intact-corticospinal-tract-axonal-sprouting-and-functional-recovery-after-traumatic-brain-injury-in-mice
#35
JOURNAL ARTICLE
Beike Chen, Qiang Tan, Hongyan Zhang, Weihua Chu, Huizhong Wen, Xuelong Tian, Yang Yang, Weina Li, Wenyan Li, Yujie Chen, Hua Feng
BACKGROUND: Anodal transcranial direct current stimulation (AtDCS), a neuromodulatory technique, has been applied to treat traumatic brain injury (TBI) in patients and was reported to promote functional improvement. We evaluated the effect of contralesional AtDCS on axonal sprouting of the intact corticospinal tract (CST) and the underlying mechanism in a TBI mouse model to provide more preclinical evidence for the use of AtDCS to treat TBI. METHODS: TBI was induced in mice by a contusion device...
March 2024: Neurorehabilitation and Neural Repair
https://read.qxmd.com/read/38385233/-experimental-study-of-m2-microglia-transplantation-promoting-spinal-cord-injury-repair-in-mice
#36
JOURNAL ARTICLE
Jing Zhang, Xiaoyue Zhang, Qi Jiang, Di Qu, Yusheng Hu, Chao Qi, Haitao Fu
OBJECTIVE: To investigate the effect of M2 microglia (M2-MG) transplantation on spinal cord injury (SCI) repair in mice. METHODS: Primary MG were obtained from the cerebral cortex of 15 C57BL/6 mice born 2-3 days old by pancreatic enzyme digestion and identified by immunofluorescence staining of Iba1. Then the primary MG were co-cultured with interleukin 4 for 48 hours (experimental group) to induce into M2 phenotype and identified by immunofluorescence staining of Arginase 1 (Arg-1) and Iba1...
February 15, 2024: Chinese Journal of Reparative and Reconstructive Surgery
https://read.qxmd.com/read/38384987/development-of-ovalbumin-implants-with-different-spatial-configurations-for-treatment-of-peripheral-nerve-injury
#37
JOURNAL ARTICLE
Tiantian Zheng, Hongxia Gao, Yaqiong Liu, Shaolan Sun, Wenchao Guan, Linliang Wu, Yumin Yang, Guicai Li
Peripheral nerve injury (PNI) seriously affects the health and life of patients, and is an urgent clinical problem that needs to be resolved. Nerve implants prepared from various biomaterials have played a positive role in PNI, but the effect should be further improved and thus new biomaterials is urgently needed. Ovalbumin (OVA) contains a variety of bioactive components, low immunogenicity, tolerance, antimicrobial activity, non-toxicity and biodegradability, and has the ability to promote wound healing, cell growth and antimicrobial properties...
May 2024: Bioactive Materials
https://read.qxmd.com/read/38380783/annexin-a6-mitigates-neurological-deficit-in-ischemia-reperfusion-injury-by-promoting-synaptic-plasticity
#38
JOURNAL ARTICLE
Yilin Wang, Zhenhong Yang, Rongliang Wang, Yangmin Zheng, Ziping Han, Junfen Fan, Feng Yan, Ping Liu, Yumin Luo
AIMS: Alleviating neurological dysfunction caused by acute ischemic stroke (AIS) remains intractable. Given Annexin A6 (ANXA6)'s potential in promoting axon branching and repairing cell membranes, the study aimed to explore ANXA6's potential in alleviating AIS-induced neurological dysfunction. METHODS: A mouse middle cerebral artery occlusion model was established. Brain and plasma ANXA6 levels were detected at different timepoints post ischemia/reperfusion (I/R)...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38377534/bioadhesive-hyaluronic-acid-based-hydrogels-for-spinal-cord-injury
#39
JOURNAL ARTICLE
Diogo Duarte, Cátia Correia, Rui L Reis, Iva Pashkuleva, Daniela Peixoto, Natália M Alves
Spinal cord injuries (SCI) have devastating physical, psychological, and psychosocial consequences for patients. One challenge of nerve tissue repair is the lack of a natural extracellular matrix (ECM) that guides the regenerating axons. Hyaluronic acid (HA) is a major ECM component and plays a fundamental role in facilitating lesion healing. Herein, we developed HA-based adhesive hydrogels by modification of HA with dopamine, a mussel-inspired compound with excellent adhesive properties in an aqueous environment...
February 20, 2024: Biomacromolecules
https://read.qxmd.com/read/38373567/fabrication-of-multifunctional-silk-nanofibril-hyaluronic-acid-scaffold-for-spinal-cord-repair
#40
JOURNAL ARTICLE
Ao Huang, Ying Huang, Wenjing Yang, Lu Wang, Renchuan You, Jiannan Wang, Shuqin Yan, Qiang Zhang
Bioactive scaffolds accurately mimicking the structure and composition of the extracellular matrix have garnered significant interest in tissue engineering. In this study, we developed a platform utilizing natural silk nanofibrils, hyaluronic acid, and basic fibroblast growth factor for the purpose of promoting spinal cord regeneration by creating an optimal microenvironment. The bioactive scaffold exhibited notable characteristics such as high porosity and hydrophilicity, attributed to its unique nanostructure, high connectivity, and polysaccharide composition...
February 17, 2024: International Journal of Biological Macromolecules
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