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https://www.readbyqxmd.com/read/27861433/understanding-phenotypes-of-obstructive-sleep-apnea-applications-in-anesthesia-surgery-and-perioperative-medicine
#1
Yamini Subramani, Mandeep Singh, Jean Wong, Clete A Kushida, Atul Malhotra, Frances Chung
Obstructive sleep apnea (OSA) is a prevalent sleep-disordered breathing with potential long-term major neurocognitive and cardiovascular sequelae. The pathophysiology of OSA varies between individuals and is composed of different underlying mechanisms. Several components including the upper airway anatomy, effectiveness of the upper airway dilator muscles such as the genioglossus, arousal threshold of the individual, and inherent stability of the respiratory control system determine the pathogenesis of OSA...
November 17, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27668002/the-effects-of-nutritional-juice-supplementation-on-the-extent-of-climacteric-symptoms-an-observational-study
#2
Stefanie I Siebler, Ursula Gresser, Barbara M Richartz
Objective. This study aims to evaluate the effect of daily dietary nutritional supplement on somatic, psychological, and urogenital symptoms in postmenopausal women. Material and Methods. In this study 28 healthy, symptomatic, peri- and postmenopausal women of 47-67 years of age were allocated to use the nutritional supplement JuicePLUS+®. Primary research parameters: Menopause Rating Scale (MRS) was used to assess menopausal symptoms at baseline and after 8 and 16 weeks of treatment. Secondary parameters: proliferation behaviour of vaginal smear was scored at baseline and after treatment...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27605136/quality-of-life-priorities-in-patients-with-thyroid-cancer-a-multinational-european-organisation-for-research-and-treatment-of-cancer-phase-i-study
#3
Susanne Singer, Olga Husson, Iwona M Tomaszewska, Laura D Locati, Naomi Kiyota, Ulrike Scheidemann-Wesp, Dirk Hofmeister, Melanie Winterbotham, Christine Brannan, Cláudia Araújo, Eva M Gamper, Dagmara Kulis, Harald Rimmele, Guy Andry, Lisa Licitra
BACKGROUND: The objectives of this study were to determine quality of life (QoL) issues that are relevant to thyroid cancer patients cross-culturally, and to identify those with highest relevance to them in addition to the more general issues covered by the core European Organisation for Research and Treatment of Cancer QoL questionnaire (EORTC QLQ-C30). METHODS: A systematic literature search provided a list of potentially relevant QoL issues to supplement the core questionnaire EORTC QLQ-C30, which is widely used in research and in care and addresses QoL issues relevant to all groups of cancer patients...
October 12, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27580590/sleep-patterns-among-shift-working-flight-controllers-of-the-international-space-station-an-observational-study-on-the-jaxa-flight-control-team
#4
Koh Mizuno, Akiko Matsumoto, Tatsuya Aiba, Takashi Abe, Hiroshi Ohshima, Masaya Takahashi, Yuichi Inoue
BACKGROUND: Flight controllers of the International Space Station (ISS) are engaged in shift work to provide 24-h coverage to support ISS systems. The purpose of this study was to investigate the prevalence and associated factors of shift work sleep disorder (SWSD) among Japanese ISS flight controllers. METHODS: A questionnaire study was conducted using the Standard Shiftwork Index to evaluate sleep-related problems and possible associated variables. Among 52 respondents out of 73 flight controllers, 30 subjects were identified as night shift workers who worked 3 or more night shifts per month...
2016: Journal of Physiological Anthropology
https://www.readbyqxmd.com/read/27479478/nonpharmacological-alternatives-to-benzodiazepine-drugs-for-the-treatment-of-anxiety-in-outpatient-populations-a-literature-review
#5
Lois M Platt, Amy Irene Whitburn, Alexander G Platt-Koch, Ronald L Koch
Overuse of benzodiazepine drugs to treat anxiety, mood, and sleep disorders is a growing problem in clinical practice. GABAergic medications (benzodiazepine drugs in particular) have side effects, drug interactions, and the potential to create tolerance and dependence in users. GABA-enhancing dietary supplements have similar and unique risks. Natural, non-chemical, anxiolytic treatments exist and can be safely recommended to patients. Three such treatments have been the focus of study in the past 20 years: mindfulness, meditation, and yoga...
August 1, 2016: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/27435520/idiopathic-focal-epilepsies-the-lost-tribe
#6
Deb K Pal, Colin Ferrie, Laura Addis, Tomoyuki Akiyama, Giuseppe Capovilla, Roberto Caraballo, Anne de Saint-Martin, Natalio Fejerman, Renzo Guerrini, Khalid Hamandi, Ingo Helbig, Andreas A Ioannides, Katsuhiro Kobayashi, Dennis Lal, Gaetan Lesca, Hiltrud Muhle, Bernd A Neubauer, Tiziana Pisano, Gabrielle Rudolf, Caroline Seegmuller, Takashi Shibata, Anna Smith, Pasquale Striano, Lisa J Strug, Pierre Szepetowski, Thalia Valeta, Harumi Yoshinaga, Michalis Koutroumanidis
The term idiopathic focal epilepsies of childhood (IFE) is not formally recognised by the ILAE in its 2010 revision (Berg et al., 2010), nor are its members and boundaries precisely delineated. The IFEs are amongst the most commonly encountered epilepsy syndromes affecting children. They are fascinating disorders that hold many "treats" for both clinicians and researchers. For example, the IFEs pose many of the most interesting questions central to epileptology: how are functional brain networks involved in the manifestation of epilepsy? What are the shared mechanisms of comorbidity between epilepsy and neurodevelopmental disorders? How do focal EEG discharges impact cognitive functioning? What explains the age-related expression of these syndromes? Why are EEG discharges and seizures so tightly locked to slow-wave sleep? In the last few decades, the clinical symptomatology and the respective courses of many IFEs have been described, although they are still not widely appreciated beyond the specialist community...
September 1, 2016: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/27101340/zeigarnik-s-sleepless-nights-how-unfinished-tasks-at-the-end-of-the-week-impair-employee-sleep-on-the-weekend-through-rumination
#7
Christine J Syrek, Oliver Weigelt, Corinna Peifer, Conny H Antoni
It is almost common sense that work stress leads to sleep impairment, but the question of how work-related stressors impair employee sleep remains open. This study focuses on the role of rumination as the underlying mechanism for sleep impairment. Specifically, the authors contribute to recent research differentiating affective rumination from problem-solving pondering and examine the impact of both forms of rumination on the stressor-sleep relationship. Following theories of rumination and the Zeigarnik effect, they focus on unfinished tasks as a key onset for rumination...
April 21, 2016: Journal of Occupational Health Psychology
https://www.readbyqxmd.com/read/27057659/burden-of-illness-in-fibromyalgia-patients-with-comorbid-depression
#8
RANDOMIZED CONTROLLED TRIAL
Lucinda Bateman, Piercarlo Sarzi-Puttini, Claire L Burbridge, Jaren W Landen, Elizabeth T Masters, Pritha Bhadra Brown, Joseph M Scavone, Birol Emir, Richard S Vissing, Andrew G Clair, Lynne R Pauer
OBJECTIVES: To assess the burden of fibromyalgia (FM) in patients with FM taking antidepressant medication for comorbid depression. METHODS: Symptom burden, impact on work and activity, and healthcare resource utilisation (HCRU) was examined at randomisation in patients enrolled in a clinical trial. Symptom burden was estimated based on self-reported health status measures. The Work Productivity and Activity Impairment: Specific Health Problem scale adapted to FM and a separate HCRU questionnaire were completed...
March 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27015641/establishing-a-pragmatic-framework-to-optimise-health-outcomes-in-heart-failure-and-multimorbidity-arise-hf-a-multidisciplinary-position-statement
#9
Simon Stewart, Barbara Riegel, Cynthia Boyd, Yasmin Ahamed, David R Thompson, Louise M Burrell, Melinda J Carrington, Andrew Coats, Bradi B Granger, Julie Hides, William S Weintraub, Debra K Moser, Victoria Vaughan Dickson, Cressida J McDermott, Ashley K Keates, Michael W Rich
BACKGROUND: Multimorbidity in heart failure (HF), defined as HF of any aetiology and multiple concurrent conditions that require active management, represents an emerging problem within the ageing HF patient population worldwide. METHODS: To inform this position paper, we performed: 1) an initial review of the literature identifying the ten most common conditions, other than hypertension and ischaemic heart disease, complicating the management of HF (anaemia, arrhythmias, cognitive dysfunction, depression, diabetes, musculoskeletal disorders, renal dysfunction, respiratory disease, sleep disorders and thyroid disease) and then 2) a review of the published literature describing the association between HF with each of the ten conditions...
June 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/26938543/reduction-of-endogenous-melatonin-accelerates-cognitive-decline-in-mice-in-a-simulated-occupational-formaldehyde-exposure-environment
#10
Yufei Mei, Chunli Duan, Xiaoxiao Li, Yun Zhao, Fenghua Cao, Shuai Shang, Shumao Ding, Xiangpei Yue, Ge Gao, Hui Yang, Luxi Shen, Xueyan Feng, Jianping Jia, Zhiqian Tong, Xu Yang
Individuals afflicted with occupational formaldehyde (FA) exposure often suffer from abnormal behaviors such as aggression, depression, anxiety, sleep disorders, and in particular, cognitive impairments. Coincidentally, clinical patients with melatonin (MT) deficiency also complain of cognitive problems associated with the above mental disorders. Whether and how FA affects endogenous MT metabolism and induces cognitive decline need to be elucidated. To mimic occupational FA exposure environment, 16 healthy adult male mice were exposed to gaseous FA (3 mg/m³) for 7 consecutive days...
March 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/26889894/commentary-thinking-outside-the-box-about-children-s-sleep-a-commentary-on-gregory-and-sadeh-2016
#11
COMMENT
Gregory Stores
This commentary is intended to supplement the accompanying review of sleep problems in childhood psychiatric disorders by Gregory and Sadeh. A number of considerations are outlined because of their relevance to both clinical practice and research concerning assessment and treatment of sleep disturbance in children in general and especially those with psychiatric and/or neurological conditions. These considerations (which illustrate the importance of combined medical and psychological involvement) are as follows: the importance of screening for sleep disturbance which otherwise may well be overlooked; the need to specify sleep disorders rather than simply nonspecific sleep problems as this will guide choice of appropriate advice and treatment; the risk of sleep disorders being misdiagnosed because of clinicians' unfamiliarity with the sleep disorders field; the possibility that a child's sleep disturbance is of multiple aetiology; a wide range of treatments for disturbed sleep is now described from which a choice is possible given an accurate diagnosis; sleep problems may be intensified if a child's condition is complicated by intellectual disability but the same principles of assessment and management apply as in other children in the expectation that treatment can be effective...
March 2016: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/26867698/the-efficacy-of-the-appetite-suppressant-diethylpropion-is-dependent-on-both-when-it-is-given-day-vs-night-and-under-conditions-of-high-fat-dietary-restriction
#12
B Kalyanasundar, Jessica Solorio, Claudia I Perez, Carlos Hoyo-Vadillo, Sidney A Simon, Ranier Gutierrez
Obesity is a public health problem caused by excessive consumption of high caloric diets and/or lack of physical activity. Although treatments for obesity include low caloric diets and exercise programs, these activities frequently are supplemented with appetite suppressants. For the short-term treatment of weight loss, diethylpropion (DEP) is a commonly used appetite suppressant. However, little is known with regard to how to improve its weight loss efficacy. We therefore evaluated, in rats, two administration protocols where the animals received daily injections of DEP...
May 1, 2016: Appetite
https://www.readbyqxmd.com/read/26799351/management-of-sleep-disorders-in-children-with-neurodevelopmental-disorders-a-review
#13
REVIEW
Allison Beck Blackmer, James A Feinstein
Neurodevelopmental disorders (NDDs) are defined as a group of disorders caused by changes in early brain development, resulting in behavioral and cognitive alterations in sensory and motor systems, speech, and language. NDDs affect approximately 1-2% of the general population. Up to 80% of children with NDDs are reported to have disrupted sleep; subsequent deleterious effects on daytime behaviors, cognition, growth, and overall development of the child are commonly reported. Examples of NDDs discussed in this review include autism spectrum disorder, cerebral palsy, Rett syndrome, Angelman syndrome, Williams syndrome, and Smith-Magenis syndrome...
January 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/26779860/pharmacotherapy-for-mental-health-problems-in-people-with-intellectual-disability
#14
REVIEW
Na Young Ji, Robert L Findling
PURPOSE OF REVIEW: Psychotropic medications are commonly prescribed to people with intellectual disability. We reviewed current evidence-based pharmacotherapy options and recent updates to guide clinicians in their medication management plans. RECENT FINDINGS: Antipsychotics, particularly risperidone, appear to be effective in reducing problem behaviors in children with intellectual disability. Evidence in adults is inconclusive. Methylphenidate appears to be effective, and α-agonists appear promising in reducing attention-deficit hyperactivity disorder symptoms...
March 2016: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/26569624/melatonin-supplementation-for-children-with-atopic-dermatitis-and-sleep-disturbance-a-randomized-clinical-trial
#15
RANDOMIZED CONTROLLED TRIAL
Yung-Sen Chang, Ming-Hung Lin, Jyh-Hong Lee, Pei-Lin Lee, Yang-Shia Dai, Kuan-Hua Chu, Chi Sun, Yu-Tsan Lin, Li-Chieh Wang, Hsin-Hui Yu, Yao-Hsu Yang, Chun-An Chen, Kong-Sang Wan, Bor-Luen Chiang
IMPORTANCE: Sleep disturbance is common in children with atopic dermatitis (AD), but effective clinical management for this problem is lacking. Reduced levels of nocturnal melatonin were found to be associated with sleep disturbance and increased disease severity in children with AD. Melatonin also has sleep-inducing and anti-inflammatory properties and therefore might be useful for the management of AD. OBJECTIVE: To evaluate the effectiveness of melatonin supplementation for improving the sleep disturbance and severity of disease in children with AD...
January 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/26205312/treatment-of-creatine-transporter-slc6a8-deficiency-with-oral-s-adenosyl-methionine-as-adjunct-to-l-arginine-glycine-and-creatine-supplements
#16
Sravan Jaggumantri, Mary Dunbar, Vanessa Edgar, Cristina Mignone, Theresa Newlove, Rajavel Elango, Jean Paul Collet, Michael Sargent, Sylvia Stockler-Ipsiroglu, Clara D M van Karnebeek
BACKGROUND: Creatine transporter (SLC6A8) deficiency is an X-linked inborn error of metabolism characterized by cerebral creatine deficiency, behavioral problems, seizures, hypotonia, and intellectual developmental disability. A third of patients are amenable to treatment with high-dose oral creatine, glycine, and L-arginine supplementation. METHODS: Given the limited treatment response, we initiated an open-label observational study to evaluate the effect of adjunct S-adenosyl methionine to further enhance intracerebral creatine synthesis...
October 2015: Pediatric Neurology
https://www.readbyqxmd.com/read/26180776/baseline-subjective-memory-complaints-associate-with-increased-risk-of-incident-dementia-the-preadvise-trial
#17
E L Abner, R J Kryscio, A M Caban-Holt, F A Schmitt
BACKGROUND: Subjective memory complaints reflect patient-identified deficits in memory and have been linked to increased risk of future dementia in nondemented (including cognitively intact) older adults. OBJECTIVES: To assess the risk of incident dementia during follow-up for participants in the Prevention of Alzheimer's Disease with Vitamin E and Selenium (PREADVISE) study who reported memory complaints at baseline. DESIGN: Double-blind, placebo controlled 2×2 randomized controlled trial that transformed into an observational cohort following discontinuation of supplementation in the SELECT parent trial...
March 2015: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/26134878/mds-updrs-to-assess-non-motor-symptoms-after-stn-dbs-for-parkinson-s-disease
#18
Nickey Jafari, Rajesh Pahwa, Jules M Nazzaro, Paul M Arnold, Kelly E Lyons
OBJECTIVE: To determine if the non-motor sections of the Movement Disorder Society's (MDS) version of the Unified Parkinson's Disease Rating Scale (UPDRS) could supplement the original UPDRS as a patient completed assessment of changes in non-motor symptoms in Parkinson's disease (PD) patients after bilateral subthalamic nucleus (STN) deep brain stimulation (DBS). METHODS: Thirty PD patients who underwent bilateral STN DBS were assessed using the total UPDRS and the non-motor sections of the MDS-UPDRS prior to surgery and one year following surgery...
2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/26109383/using-non-invasive-bi-level-positive-airway-pressure-ventilator-via-tracheostomy-in-children-with-congenital-central-hypoventilation-syndrome-two-case-reports
#19
Aroonwan Preutthipan, Teeradej Kuptanon, Harutai Kamalaporn, Anchalee Leejakpai, Malinee Nugboon, Duangrurdee Wattanasirichaigoon
INTRODUCTION: Due to the economic downturn in Thailand, two baby girls with congenital central hypoventilation syndrome had to wait for several months to obtain definite diagnosis and long-term mechanical ventilation. Genetic investigation later revealed 20/25 polyalanine expansion of PHOX2B gene in both girls. In this report we highlight the use of non-invasive bi-level positive airway pressure ventilators via tracheostomy, overnight end-tidal carbon dioxide trend graphs and outcomes of the patients whose diagnosis and treatment were delayed...
2015: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/26103557/inter-relationships-of-the-chronobiotic-melatonin-with-leptin-and-adiponectin-implications-for-obesity
#20
REVIEW
Karolina Szewczyk-Golec, Alina Woźniak, Russel J Reiter
Obesity and its medical complications represent a significant problem throughout the world. In recent decades, mechanisms underlying the progression of obesity have been intensively examined. The involvement of both the behavioral aspects, such as calorie-rich diet, low physical activity and sleep deprivation, and the intrinsic factors, including adipose tissue deregulation, chronic inflammation, oxidative stress, and chronodisruption, has been identified. The circadian disturbances of the adipose tissue endocrine function have been correlated with obesity...
October 2015: Journal of Pineal Research
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