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https://www.readbyqxmd.com/read/29666565/postnatal-vitamin-d-intake-modulates-hippocampal-learning-and-memory-in-adult-mice
#1
Qiujuan Liang, Chunhui Cai, Dongxia Duan, Xinyu Hu, Wanhao Hua, Peicheng Jiang, Liu Zhang, Jun Xu, Zhengliang Gao
Vitamin D (VD) is a neuroactive steroid crucial for brain development, function and homeostasis. Its deficiency is associated with numerous brain conditions. As such, VD and its variants are routinely taken by a broad of groups with/without known VD deficiency. In contrast, the harmful effects of VD overdose have been poorly studied. Similarly, the developmental stage-specific VD deficiency and overdose have been rarely explored. In the present work, we showed that postnatal VD supplementation enhanced the motor function transiently in the young adult, but not in the older one...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29665586/-working-conditions-and-mental-health-among-salaried-physicians-a-nationwide-comparison-with-a-representative-sample-of-employees
#2
Uwe Rose, Grit Müller, Gabriele Freude, Norbert Kersten
AIM: Do the amount of workload, strain and the association between both differ between employed physician and other employees subject to social security contributions? This is investigated in this present study by comparing two representative samples. METHODS: Psycho-social working conditions were by assessed computer-assisted personal interviews and supplemented by questions about burnout and depressive symptoms. The associations were investigated by linear regression analysis including moderating effects due to differences between occupations...
April 17, 2018: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29664551/socio-demographic-and-psychological-determinants-of-exclusive-breastfeeding-after-six-months-postpartum-a-polish-case-cohort-study
#3
Karolina Maria Maliszewska, Mariola Bidzan, Małgorzata Świątkowska-Freund, Krzysztof Preis
OBJECTIVES: The purpose of this study was to explore the socio-demographic and psychological factors connected with exclusive breastfeeding after 6 months postpartum. MATERIAL AND METHODS: A total of 251 women filled in questionnaires in the first week postpartum, then again after 3 and 6 months. The questionnaires included socio-demographic and medical questions, as well as psychological tools: the NEO-FFI Personality Inventory, the Berlin Social Support Scales (BSSS), and the Edinburgh Postnatal Depression Scale (EPDS)...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29663652/a-longitudinal-study-of-serum-insulin-like-growth-factor-i-igf-i-levels-over-six-years-in-a-large-cohort-of-children-and-adolescents-with-type-1-diabetes-mellitus-a-marker-reflecting-diabetic-retinopathy
#4
Daniel Öberg, Jenny Salemyr, Eva Örtqvist, Anders Juul, Peter Bang
OBJECTIVE: To evaluate longitudinal serum IGF-I in a large cohort of children and adolescents with type 1 diabetes in relation to HbA1c, age, diabetes duration, and BMI, its association to height and retinopathy, and in comparison with healthy subject references. RESEARCH DESIGN AND METHODS: A total of 2,683 serum IGF-I values were obtained from 806 children and adolescents with T1DM, from annual blood samples for up to 6 consecutive years. RESULTS: In a multiple regression analysis IGF-I values were negatively correlated to HbA1c and diabetes duration, and positively correlated to BMI (p<0...
April 16, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29657562/mental-health-disorder-therapeutic-modalities-modified-for-the-gms
#5
REVIEW
Tipsuda Sumneangsanor, Sararud Vuthiarpa, Chomchueun Somprasert
Background: Mental health disorders can affect physical and psychological behaviors. The people of the Greater Mekong Subregion (GMS) have a high risk of mental health disorders, such as depression, stress, and substance abuse be-cause the people in this region are trafficked for forced sex work and various forms of forced labor. In these situations, vic-tims often endure violence and abuse from trafficking recruiters, employers, and other individuals. The purposes of this study were to identify the elements characterizing mental health disorders, especially in terms of depression, stress, and sub-stance abuse, and to identify the treatment modalities for mental health disorders in the GMS...
December 2017: Current Psychiatry Reviews
https://www.readbyqxmd.com/read/29651640/characteristics-of-new-onset-and-chronic-sleep-medication-users-among-older-adults-a-retrospective-study-of-a-us-medigap-plan-population-using-propensity-score-matching
#6
Shirley Musich, Shaohung S Wang, Luke B Slindee, Lynn Saphire, Ellen Wicker
BACKGROUND: Prescription sleep medications are often utilized to manage sleep problems among older adults even though these drugs are associated with multiple risks. OBJECTIVE: The aim was to determine the prevalence and characteristics of new-onset compared to chronic sleep medication users and to examine factors associated with the conversion from new to chronic use. A secondary objective was to investigate the impact of sleep medications on health outcomes of injurious falls and patterns of healthcare utilization and expenditures...
April 12, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29649036/association-between-alexithymia-and-risk-of-incident-cardiovascular-diseases-in-the-suppl%C3%A3-mentation-en-vitamines-et-min%C3%A3-raux-antioxydants-su-vi-max-cohort
#7
Emmanuel Wiernik, Cédric Lemogne, Léopold Fezeu, Nathalie Arnault, Serge Hercberg, Emmanuelle Kesse-Guyot, Pilar Galan
OBJECTIVE: Although alexithymia has been suggested to be associated with cardiovascular diseases, studies are scarce and a causal relationship is questionable. This study explored the prospective association between alexithymia and cardiovascular events in middle-aged participants without cardiovascular history at baseline. METHODS: The 26-item Toronto Alexithymia Scale (TAS-26) was completed by 5,586 participants of the French Supplémentation en Vitamines et Minéraux AntioXydants (SU...
April 11, 2018: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29628849/pectoralis-blocks-for-insertion-of-an-implantable-cardioverter-defibrillator-in-two-patients-with-duchenne-muscular-dystrophy
#8
Alexander B Froyshteter, Tarun Bhalla, Joseph D Tobias, Gregory S Cambier, Christopher T Mckee
Patients with Duchenne muscular dystrophy (DMD) often have systemic manifestations with comorbid involvement of the cardiac and respiratory systems that increase the risk of anesthetic and perioperative morbidity. These patients frequently develop progressive myocardial involvement with cardiomyopathy, depressed cardiac function, and arrhythmias. The latter may necessitate the placement of an automatic implantable cardioverter defibrillator (AICD) insertion. As a means of avoiding the need for general anesthesia and its inherent potential of morbidity, regional anesthesia may be used in specific cases...
April 2018: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/29628065/modulating-emotion-perception-opposing-effects-of-inhibitory-and-excitatory-prefrontal-cortex-stimulation
#9
Swantje Notzon, Christian Steinberg, Peter Zwanzger, Markus Junghöfer
BACKGROUND: Excitatory repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (dlPFC) is approved by the U.S. Food and Drug Administration for the treatment of adult patients with treatment-resistant major depressive disorder (MDD). This stimulation is supposed to restore excitability of prefrontal cortex regions that exhibit diminished regulation of emotion-generative systems in MDD. Based on the valence lateralization hypothesis, inhibitory rTMS of the right dlPFC has also been applied in MDD...
April 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29626640/differential-responses-to-cd-stress-induced-by-exogenous-application-of-cu-zn-or-ca-in-the-medicinal-plant-catharanthus-roseus
#10
Qi Chen, Xueyan Lu, Xiaorui Guo, Yajie Pan, Bofan Yu, Zhonghua Tang, Qingxi Guo
Cd(II) is one of the most widespread and toxic heavy metals and seriously threatens plant growth, furthermore negatively affecting human health. For survival from this metal stress, plants always fight with Cd(II) toxicity by themselves or using other external factors. The effects of second metals copper (Cu(II)), zinc (Zn(II)) and calcium (Ca(II)) on the Cd(II)-affected root morphology, Cd(II) translocation and metabolic responses in Catharanthus roseus were investigated under hydroponic conditions. We found that the Cd-stressed plants displayed the browning and rot root symptom, excess H2 O2 content, lipid peroxidation and Cd(II) accumulation in plants...
April 4, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29625166/neuroprotective-effect-of-a-physiological-ratio-of-testosterone-and-estradiol-on-corticosterone-induced-apoptosis-in-pc12-cells-via-traf6-tak1-pathway
#11
Rui Peng, Wen Dai, Yan Li
Clinical and experimental studies suggested that testosterone or estradiol alone supplementation may have antidepressant-like effects. However, the synergistic effect of testosterone/estradiol on the treatment of depression and the underlying mechanism remain largely unknown. Here, we hypothesized that an appropriate dosage of testosterone combined with estradiol may became a new therapeutic strategy in depression. Our results indicated that an appropriate testosterone/estradiol ratio of 10:1 (10-8  mol/L testosterone and 10-9  mol/L estradiol) was found, which has a significant synergistic anti-apoptotic effect on PC12 cells injury stimulated by corticosterone...
April 3, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29619936/intravenous-iron-treatment-in-the-puerperium
#12
Charlotte Holm
Iron deficiency and anaemia in the puerperium are associated with several important clinical consequences, most prominently physical fatigue. Current treatment practice with oral iron supplementation is associated with gastrointestinal side-effects and subsequent poor compliance. Red blood cell transfusion is also widely used to treat severe postpartum anaemia, though accumulating evidence questions its risk-benefit ratio. Intravenous iron has in previous studies been associated with fast improvement of haemoglobin and iron biochemical markers in the treatment of postpartum anaemia, but there is a lack of studies on patient reported outcomes...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29615976/higher-prevalence-of-low-t3-syndrome-in-patients-with-chronic-fatigue-syndrome-a-case-control-study
#13
Begoña Ruiz-Núñez, Rabab Tarasse, Emar F Vogelaar, D A Janneke Dijck-Brouwer, Frits A J Muskiet
Chronic fatigue syndrome (CFS) is a heterogeneous disease with unknown cause(s). CFS symptoms resemble a hypothyroid state, possibly secondary to chronic (low-grade) (metabolic) inflammation. We studied 98 CFS patients (21-69 years, 21 males) and 99 age- and sex-matched controls (19-65 years, 23 males). We measured parameters of thyroid function, (metabolic) inflammation, gut wall integrity and nutrients influencing thyroid function and/or inflammation. Most remarkably, CFS patients exhibited similar thyrotropin, but lower free triiodothyronine (FT3) (difference of medians 0...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29611892/mlc901-neuroaid-ii-%C3%A2-for-cognition-after-traumatic-brain-injury-a-pilot-randomised-clinical-trial
#14
Alice Theadom, Suzanne Barker-Collo, Kelly M Jones, Priya Parmar, Rohit Bhattacharjee, Valery L Feigin
BACKGROUND: Treatments to facilitate recovery after traumatic brain injury (TBI) are urgently needed. To examine the safety and potential effects of herbal supplement MLC901 (NeuroAiD IITM ) on cognitive functioning following TBI, we conducted a nine-month pilot, randomised placebo-controlled clinical trial. METHODS: Adults aged 18-65 years, 1-12-months post-mild or moderate TBI, were randomised to receive MLC901 (0.8g capsules/day) or placebo for 6-months. The primary outcome was cognitive functioning assessed by the CNS-Vital Signs online neuropsychological test...
April 3, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29603100/relationship-of-dietary-and-serum-zinc-with-depression-score-in-iranian-adolescent-girls
#15
Kayhan Gonoodi, Alireza Moslem, Mahsa Ahmadnezhad, Susan Darroudi, Zahra Mazloum, Maryam Tayefi, Seyed Amir Tabatabaeizadeh, Saeid Eslami, Mojtaba Shafiee, Zahra Khashayarmanesh, Hamideh Moalemzadeh Haghighi, Gordon A Ferns, Majid Ghayour-Mobarhan
Zinc deficiency, which is common among Iranian populations, is believed to play a crucial role in the onset and progression of mood disorders such as depression in different stages of life. We have therefore investigated the relationship between serum/dietary zinc status and depression scores among adolescent girls living in northeastern Iran. Serum zinc was measured by flame atomic absorption (Varian AA240FS) and the mean zinc intake was assessed using 3-day food record. A validated Persian version of the Beck Depression Inventory (BDI) was used to determine the severity of depressive symptoms for all subjects...
March 30, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29596118/treatment-of-depression-with-duloxetine-in-mitochondrial-encephalopathy-lactic-acidosis-and-stroke-like-episodes
#16
Brittany Cozart, Jesus Diaz Vera, James D Denham, William L Whiting
The mitochondrial cytopathies are a heterogeneous group of diseases characterized by heteroplasmic maternal transmission and selective dysfunction of tissues and organs highly dependent on aerobic respiration (eg, skeletal muscle, cardiac muscle, and brain). Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) is a specific subtype of mitochondrial cytopathy that is commonly associated with mood disturbances in individuals who survive until adulthood. Because of the altered cellular metabolism inherent in MELAS, it is often difficult to determine drug dosing, drug choice, and treatment response in patients with this rare disease...
March 28, 2018: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29576358/a-lecithin-phosphatidylserine-and-phosphatidic-acid-complex-pas-reduces-symptoms-of-the-premenstrual-syndrome-pms-results-of-a-randomized-placebo-controlled-double-blind-clinical-trial
#17
Katja Schmidt, Nicole Weber, Meir Steiner, Nadin Meyer, Anne Dubberke, David Rutenberg, Juliane Hellhammer
BACKGROUND & AIMS: Many women experience emotional and physical symptoms around the time of ovulation and more so before menstruation interfering with their daily normal life also known as premenstrual syndrome (PMS). Recent observational data suggest that supplementation with Lipogen's phosphatidylserine (PS) and phosphatidic acid (PA) complex (PAS) alleviates these PMS symptoms. The aim of this study was to confirm these observations on the effects of PAS on PMS symptom severity within a controlled clinical trial setting...
April 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29575441/lactobacillus-plantarum-mtcc-9510-supplementation-protects-from-chronic-unpredictable-and-sleep-deprivation-induced-behaviour-biochemical-and-selected-gut-microbial-aberrations-in-mice
#18
Jatinder Dhaliwal, Dhirendra Pratap Singh, Shashank Singh, P Anil Kumar, Ravneet Kaur Boparai, Mahendra Bishnoi, Kanthi Kiran Kondepudi, Kanwaljit Chopra
AIM: Here we evaluated any beneficial effects of a potential probiotic bacterial strain (Lactobacillus plantarum MTCC 9510) in two different stress paradigms in mice. METHODS AND RESULTS: L. plantarum MTCC 9510 (2×1010 CFU per mice) was supplemented to male Swiss albino mice either subjected to chronic unpredictable mild stress or sleep deprivation stress. Various behavioral and biochemical tests along with selected gut bacterial abundances were determined. L. plantarum MTCC 9510 supplementation prevented stress-induced behavioral despair (depression, anxiety, learning and memory, stereotypic behavior), oxidative stress markers, and inflammatory cytokines in brain and serum...
March 25, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29569323/real-world-observational-results-from-a-database-of-48-million-men-in-the-united-states-relationship-of-cardiovascular-disease-diabetes-mellitus-and-depression-with-age-and-erectile-dysfunction
#19
Irwin Goldstein, Richard Chambers, WingYu Tang, Vera Stecher, Tarek Hassan
AIMS: To evaluate the relationship of comorbidities (cardiovascular disease [CVD], diabetes mellitus [DM] and depression) with erectile dysfunction (ED) and age using real-world claims data from 48 million men in the United States. METHODS: This was a cross-sectional, non-interventional study in men aged ≥18 years using data from the Truven Health MarketScan® and Medicare Supplemental Research Databases from January 2010 to December 2015, with an observational period of January 2011 to December 2014 to allow for 12 months pre- and post-index...
March 22, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29567335/effect-of-family-nursing-therapeutic-conversations-on-health-related-quality-of-life-self-care-and-depression-among-outpatients-with-heart-failure-a-randomized-multi-centre-trial
#20
Birte Østergaard, Romy Mahrer-Imhof, Lis Wagner, Torben Barington, Lars Videbæk, Jørgen Lauridsen
OBJECTIVE: To evaluate the short-term (3 months) effects of family nursing therapeutic conversations (FNTC) on health-related quality of life, self-care and depression in outpatients with Heart failure (HF). METHODS: A randomised multi-centre trial was conducted in three Danish HF clinics. The control group (n = 167) received usual care, and the intervention group (n = 180) received FNTCs as supplement to usual care. Primary outcome was clinically significant changes (6 points) in Kansas City Cardiomyopathy Questionnaire (KCCQ) summary score between groups...
March 7, 2018: Patient Education and Counseling
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