keyword
MENU ▼
Read by QxMD icon Read
search

dichloroacetate

keyword
https://www.readbyqxmd.com/read/27913098/succinyl-coa-synthetase-sucla2-deficiency-in-two-siblings-with-impaired-activity-of-other-mitochondrial-oxidative-enzymes-in-skeletal-muscle-without-mitochondrial-dna-depletion
#1
Xiaoping Huang, Jirair K Bedoyan, Didem Demirbas, David J Harris, Alexander Miron, Simone Edelheit, George Grahame, Suzanne D DeBrosse, Lee-Jun Wong, Charles L Hoppel, Douglas S Kerr, Irina Anselm, Gerard T Berry
Mutations in SUCLA2 result in succinyl-CoA ligase (ATP-forming) or succinyl-CoA synthetase (ADP-forming) (A-SCS) deficiency, a mitochondrial tricarboxylic acid cycle disorder. The phenotype associated with this gene defect is largely encephalomyopathy. We describe two siblings compound heterozygous for SUCLA2 mutations, c.985A>G (p.M329V) and c.920C>T (p.A307V), with parents confirmed as carriers of each mutation. We developed a new LC-MS/MS based enzyme assay to demonstrate the decreased SCS activity in the siblings with this unique genotype...
November 12, 2016: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/27874079/crosstalk-among-proteome-acetylome-and-succinylome-in-colon-cancer-hct116-cell-treated-with-sodium-dichloroacetate
#2
Danxi Zhu, Lidan Hou, Bin Hu, Hang Zhao, Jie Sun, Jianhua Wang, Xiangjun Meng
Protein lysine acetylation and succinylation play important regulatory roles in cells, both of which or each other has a close relationship. Dichloroacetate (DCA), a well-known pyruvate dehydrogenase kinase (PDK) inhibitor, has the potential to be used as anti-cancer drugs for several tumors including colorectal cancer. However, little is known about the potential mechanism of DCA-based cancer therapy by protein posttranslational modifications (PTM) including global proteome, acetylome and succinylome. Here the combinations with stable isotope labeling (SILAC), antibody affinity enrichment and high resolution LC-MS/MS analysis were performed in human colon cancer HCT116 cells...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27849909/267-dichloroacetic-acid-improves-neurologic-outcomes-in-a-rat-model-of-asphyxia-cardiac-arrest
#3
Peng Wang, Mingdi Chen, Zhengfei Yang, Jiali Lin, Zitong Huang, Wanchun Tang
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27803917/long-term-stabilization-of-stage-4-colon-cancer-using-sodium-dichloroacetate-therapy
#4
Akbar Khan, Douglas Andrews, Anneke C Blackburn
Oral dichloroacetate sodium (DCA) has been investigated as a novel metabolic therapy for various cancers since 2007, based on data from Bonnet et al that DCA can trigger apoptosis of human lung, breast and brain cancer cells. Response to therapy in human studies is measured by standard RECIST definitions, which define "response" by the degree of tumour reduction, or tumour disappearance on imaging. However, Blackburn et al have demonstrated that DCA can also act as a cytostatic agent in vitro and in vivo, without causing apoptosis (programmed cell death)...
October 16, 2016: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/27785718/detection-of-genotoxic-effects-of-drinking-water-disinfection-by-products-using-vicia-faba-bioassay
#5
Yu Hu, Li Tan, Shao-Hui Zhang, Yu-Ting Zuo, Xue Han, Na Liu, Wen-Qing Lu, Ai-Lin Liu
Plant-based bioassays have gained wide use among the toxicological and/or ecotoxicological assessment procedures because of their simplicity, sensitivity, low cost, and reliability. The present study describes the use of Vicia faba (V. faba) micronucleus (MN) test and V. faba comet assay in the evaluation of the genotoxic potential of disinfection by-products (DBPs) commonly found in chlorine-disinfected drinking water. Five haloacetic acids and three halogenated acetonitriles were chosen as representatives of DBPs in this study because they are of potentially great public health risk...
October 26, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27774434/fatal-liver-and-bone-marrow-toxicity-by-combination-treatment-of-dichloroacetate-and-artesunate-in-a-glioblastoma-multiforme-patient-case-report-and-review-of-the-literature
#6
Martin Uhl, Stefan Schwab, Thomas Efferth
A 52-year-old male patient was treated with standard radiochemotherapy with temozolomide for glioblastoma multiforme (GBM). After worsening of his clinical condition, further tumor-specific treatment was unlikely to be successful, and the patient seeked help from an alternative practitioner, who administered a combination of dichloroacetate (DCA) and artesunate (ART). A few days later, the patient showed clinical and laboratory signs of liver damage and bone marrow toxicity (leukopenia, thrombocytopenia). Despite successful restoration of laboratory parameters upon symptomatic treatment, the patient died 10 days after the infusion...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27771434/therapeutic-applications-of-dichloroacetate-and-the-role-of-glutathione-transferase-zeta-1
#7
REVIEW
Margaret O James, Stephan C Jahn, Guo Zhong, Marci G Smeltz, Zhiwei Hu, Peter W Stacpoole
Dichloroacetate (DCA) has several therapeutic applications based on its pharmacological property of inhibiting pyruvate dehydrogenase kinase. DCA has been used to treat inherited mitochondrial disorders that result in lactic acidosis, as well as pulmonary hypertension and several different solid tumors, the latter through its ability to reverse the Warburg effect in cancer cells and restore aerobic glycolysis. The main clinically limiting toxicity is reversible peripheral neuropathy. Although administration of high doses to rodents can result in liver cancer, there is no evidence that DCA is a human carcinogen...
October 19, 2016: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27760379/a-combined-biochemical-and-computational-studies-of-the-rho-class-glutathione-s-transferase-sll1545-of-synechocystis-pcc-6803
#8
Tripti Pandey, Rohit Shukla, Harish Shukla, Amit Sonkar, Timir Tripathi, Arvind Kumar Singh
Peroxides are one of the most important radicals that cause oxidative stress. Certain Glutathione S-transferases (GSTs) have been reported to show peroxidase activity. We report a novel peroxidase activity of Synechocystis GST- sll1545. The recombinant protein was purified to homogeneity and characterized. Low Km (0.109μM) and high Vmax (0.663μmolmin(-1)) values suggest a high preference of sll1545 for cumenehydroperoxide. Disc inhibition assay confirmed the ability of the enzyme to protect cells against peroxide-induced damage...
October 17, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27757958/dichloroacetate-induces-regulatory-t-cell-differentiation-and-suppresses-th17-cell-differentiation-by-pyruvate-dehydrogenase-kinase-independent-mechanism
#9
Naoyuki Makita, Jun Ishiguro, Keisuke Suzuki, Futoshi Nara
OBJECTIVES: Recently, there has been a growing interest in the mechanism of action of dichloroacetate (DCA) for T-cell differentiation; however, this mechanism has not been elucidated in detail. Therefore, this study aimed to investigate the mechanism of action of DCA for Treg and Th17 differentiation with pyruvate dehydrogenase kinase (PDHK) inhibitor (AZD7545) and PDHK knockdown. METHODS: Inhibitory activity of DCA and AZD7545 against recombinant PDHK and intracellular PDH phosphorylation was measured...
October 19, 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27748833/the-effect-of-dichloroacetate-in-canine-prostate-adenocarcinomas-and-transitional-cell-carcinomas-in-vitro
#10
Tatjana Harting, Mandy Stubbendorff, Saskia Willenbrock, Siegfried Wagner, Patrik Schadzek, Anaclet Ngezahayo, Hugo Murua Escobar, Ingo Nolte
The Warburg effect describes the ability of cancer cells to produce energy via aerobic glycolysis instead of oxidative phosphorylation of pyruvate. This deviation in mitochondrial metabolism inhibits apoptosis, allowing increased proliferation under conditions of reduced oxygen levels. Dichloroacetate (DCA) was successfully used in several human cancer cell lines to reactivate oxidative phosphorylation in mitochondria. The aim of this study was the characterization and response of canine cancer cell lines after DCA exposure...
October 5, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27734577/elevated-acetyl-coa-by-amino-acid-recycling-fuels-microalgal-neutral-lipid-accumulation-in-exponential-growth-phase-for-biofuel-production
#11
Lina Yao, Hui Shen, Nan Wang, Jaspaul Tatlay, Liang Li, Tin Wee Tan, Yuan Kun Lee
Microalgal neutral lipids [mainly in the form of triacylglycerols (TAGs)], feasible substrates for biofuel, are typically accumulated during the stationary growth phase. To make microalgal biofuels economically competitive with fossil fuels, generating strains that trigger TAG accumulation from the exponential growth phase is a promising biological approach. The regulatory mechanisms to trigger TAG accumulation from the exponential growth phase (TAEP) are important to be uncovered for advancing economic feasibility...
October 13, 2016: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/27726087/tio2-structures-doped-with-noble-metals-and-or-graphene-oxide-to-improve-the-photocatalytic-degradation-of-dichloroacetic-acid
#12
Paula Ribao, Maria J Rivero, Inmaculada Ortiz
Noble metals have been used to improve the photocatalytic activity of TiO2. Noble metal nanoparticles prevent charge recombination, facilitating electron transport due to the equilibration of the Fermi levels. Furthermore, noble metal nanoparticles show an absorption band in the visible region due to a high localized surface plasmon resonance (LSPR) effect, which contributes to additional electron movements. Moreover, systems based on graphene, titanium dioxide, and noble metals have been used, considering that graphene sheets can carry charges, thereby reducing electron-hole recombination, and can be used as substrates of atomic thickness...
October 11, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27685525/2-deoxy-d-glucose-enhances-dichloroacetate-antitumor-action-against-lewis-lung-carcinoma
#13
O N Pyaskovskaya, D L Kolesnik, A G Fedorchuk, I V Prokhorova, G I Solyanik
UNLABELLED: Aerobic glycolysis that supports high proliferation rate and survival of tumor cells in unfavorable conditions is among fundamental features of tumor metabolism. The search for active modulators of energetic metabolism capable of suppressing tumor growth and metastasis could result in higher effectiveness of anticancer therapy. AIM: To study antitumor and antimetastatic activity of the modulators of energetic metabolism dichloroacetate (DCA) and 2-deoxy-D-glucose (2DG) used in combination treatment of Lewis lung carcinoma (LLC)...
September 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27669387/toxicity-of-2-6-dichloro-1-4-benzoquinone-and-five-regulated-drinking-water-disinfection-by-products-for-the-caenorhabditis-elegans-nematode
#14
Yu-Ting Zuo, Yu Hu, Wei-Wei Lu, Jing-Jing Cao, Fan Wang, Xue Han, Wen-Qing Lu, Ai-Lin Liu
Scarce toxicological data are available for 2,6-dichloro-1,4-benzoquinone (DCBQ), an emerging water disinfection by-product (DBP) that is of potential public health concern. This study investigated the effects of DCBQ on the lethality, respiration rate, and DNA damage in the Caenorhabditis elegans nematode. Meanwhile, the toxic effects of five regulated DBPs, dichloroacetic acid (DCA), trichloroacetic acid (TCA), monobromoacetic acid (MBA), dibromoacetic acid (DBA), and N-nitrosodimethylamine (NDMA), have also been evaluated...
September 17, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27668346/transport-of-haloacids-across-biological-membranes
#15
REVIEW
Xianbin Su, Ruihong Li, Ka-Fai Kong, Jimmy S H Tsang
Haloacids are considered to be environmental pollutants, but some of them have also been tested in clinical research. The way that haloacids are transported across biological membranes is important for both biodegradation and drug delivery purposes. In this review, we will first summarize putative haloacids transporters and the information about haloacids transport when studying carboxylates transporters. We will then introduce MCT1 and SLC5A8, which are respective transporter for antitumor agent 3-bromopyruvic acid and dichloroacetic acid, and monochloroacetic acid transporters Deh4p and Dehp2 from a haloacids-degrading bacterium...
December 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27644545/synthesis-of-highly-polymerized-water-soluble-cellulose-acetate-by-the-side-reaction-in-carboxylate-ionic-liquid-1-ethyl-3-methylimidazolium-acetate
#16
Jinhui Pang, Xin Liu, Jun Yang, Fachuang Lu, Bo Wang, Feng Xu, Mingguo Ma, Xueming Zhang
In the present study, we describe a novel one-step method to prepare water-soluble cellulose acetate (WSCA) with higher degree of polymerization values (DP = 650-680) by in situ activation of carboxyl group in ionic liquid. First of all, cellulose was dissolved in 1-ethyl-3-methylimidazolium acetate (EmimAc) and reacted with dichloroacetyl chloride (Cl2AcCl) in order to make cellulose dichloroacetate. Under various conditions, a series of water soluble products were produced. Elemental analysis and NMR results confirmed that they were cellulose acetate with DS (degree of substitution) values in the range from 0...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27626688/diisopropylamine-dichloroacetate-enhances-radiosensitization-in-esophageal-squamous-cell-carcinoma-by-increasing-mitochondria-derived-reactive-oxygen-species-levels
#17
Gaochao Dong, Qiang Chen, Feng Jiang, Decai Yu, Qixing Mao, Wenjie Xia, Run Shi, Jie Wang, Lin Xu
Radiotherapy is generally applied in the treatment of esophageal squamous cell carcinoma (ESCC). However, the radioresistance of ESCC still remains an obstacle for the curative effect of this treatment. We hypothesized that diisopropylamine dichloroacetate (DADA), an inhibitor of pyruvate dehydrogenase kinase (PDK), might enhance radiosensitizationin resistant ESCC. The clonogenic survival assay revealed that DADA sensitized ESCC cells to radiotherapy in vitro; furthermore, the combination of DADA and radiotherapy increased the expression of γ-H2AX, which is a hallmark of DNA double-strand breaks...
September 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/27619376/use-of-zea-mays-l-in-phytoremediation-of-trichloroethylene
#18
Emanuele Moccia, Adriano Intiso, Angela Cicatelli, Antonio Proto, Francesco Guarino, Patrizia Iannece, Stefano Castiglione, Federico Rossi
Trichloroethylene (TCE) is a chlorinated aliphatic organic compound often detected as pollutant in soils and ground water. "Green technologies" based on phytoremediation were proven to be effective to reclaim organic pollutants (e.g. TCE) and heavy metals from different environmental matrices. In this work, we use Zea mays L. for the removal of high TCE concentrations from medium cultures. In particular, we investigated a sealed bioreactor where the growth medium was contaminated with an increasing amount of TCE, in the range 55-280 mg/L; the removal capability of the maize plants was assessed by means of GC-MS and LC-MS analyses...
September 13, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27585279/pilot-plant-evaluation-of-tio2-and-tio2-based-hybrid-photocatalysts-for-solar-treatment-of-polluted-water
#19
Luminita Andronic, Luminita Isac, Sara Miralles-Cuevas, Maria Visa, Isabel Oller, Anca Duta, Sixto Malato
Materials with photocatalytic and adsorption properties for advanced wastewater treatment targeting reuse were studied. Making use of TiO2 as a well-known photocatalyst, Cu2S as a Vis-active semiconductor, and fly ash as a good adsorbent, dispersed mixtures/composites were prepared to remove pollutants from wastewater. X-ray diffraction, scanning electron microscopy, energy-dispersive X-Ray spectroscopy, atomic force microscopy, band gap energy, point of zero charge (pHpzc) and BET porosity were used to characterize the substrates...
December 15, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27582548/superior-anti-tumor-efficacy-of-diisopropylamine-dichloroacetate-compared-with-dichloroacetate-in-a-subcutaneous-transplantation-breast-tumor-model
#20
Lei Su, Hailin Zhang, Chen Yan, Aiping Chen, Gang Meng, Jiwu Wei, Decai Yu, Yitao Ding
Dichloroacetate (DCA), an inhibitor of pyruvate dehydrogenase kinase, has anti-tumor properties in various carcinoma models. Diisopropylamine dichloroacetate (DADA), an over-the-counter drug for chronic liver disease, is a derivative of DCA. To date, few studies have evaluated the anticancer potential of DADA in breast cancer. In this study, MDA-MB-231 cells, a breast adenocarcinoma cell line, were used in in vitro and in vivo experiments to evaluate the anti-tumor efficacy of DADA and DCA. The half maximal inhibitory concentration (IC50) of DADA (7...
August 25, 2016: Oncotarget
keyword
keyword
51967
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"