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https://www.readbyqxmd.com/read/29470800/landiolol-a-review-in-tachyarrhythmias
#1
Yahiya Y Syed
Intravenous landiolol [Rapibloc® (EU)], an ultra short-acting highly cardioselective β1 -blocker, is approved in the EU for the rapid short-term control of tachyarrhythmias in the perioperative and intensive care settings. It has long been used in Japan to treat perioperative tachyarrhythmias. The efficacy of landiolol has been demonstrated in a large number of randomized controlled clinical trials. Landiolol significantly reduced heart rate in patients with postoperative or intraoperative supraventricular tachycardia relative to placebo and in those with atrial fibrillation/flutter and left ventricular dysfunction relative to digoxin...
February 22, 2018: Drugs
https://www.readbyqxmd.com/read/29468829/disease-progression-and-variation-in-clinical-practice-for-isolated-bicuspid-aortic-valve-in-children
#2
Melissa S W Yamauchi, Michael D Puchalski, Hsin Ti Weng, Nelangi M Pinto, Susan P Etheridge, Angela P Presson, Lloyd Y Tani, L LuAnn Minich, Richard V Williams
BACKGROUND: Disease progression of an isolated bicuspid aortic valve (BAV) in children is poorly understood and adult management guidelines may not be applicable. Thus, we sought to evaluate disease progression of pediatric isolated BAV and its relationship to current management practices. METHODS: Children with a BAV and ≤mild aortic stenosis (AS) and/or aortic regurgitation (AR) at the time of initial evaluation were included in this retrospective cohort study (1/2005-12/2014)...
February 21, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29467678/structural-immaturity-of-human-ipsc-derived-cardiomyocytes-in-silico-investigation-of-effects-on-function-and-disease-modeling
#3
Jussi T Koivumäki, Nikolay Naumenko, Tomi Tuomainen, Jouni Takalo, Minna Oksanen, Katja A Puttonen, Šárka Lehtonen, Johanna Kuusisto, Markku Laakso, Jari Koistinaho, Pasi Tavi
Background: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have emerged as a promising experimental tool for translational heart research and drug development. However, their usability as a human adult cardiomyocyte model is limited by their functional immaturity. Our aim is to analyse quantitatively those characteristics and how they differ from adult CMs. Methods and Results: We have developed a novel in silico model with all essential functional electrophysiology and calcium handling features of hiPSC-CMs...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29466214/-sudden-cardiac-death-in-patients-with-ischemic-heart-disease-from-mechanisms-to-clinical-practice
#4
E Z Golukhova, O I Gromova, N I Bulaeva, L A Bokeria
Ischemic heart disease (IHD) and acute coronary syndrome are the main cause of sudden cardiac death (SCD). Incidence of SCD in patients after myocardial infarction (MI) is 4-6-fold higher than in general population. The review focuses on electrophysiological changes during acute myocardial ischemia and mechanisms of myocardial electromechanical remodeling in remote period after MI. Current data on arrhythmia substrates and triggers are presented. Nowadays, the main guide for implantable cardioverter-defibrillator (ICD) use for primary prevention of SCD is reduced left ventricular ejection fraction...
December 2017: Kardiologiia
https://www.readbyqxmd.com/read/29465559/cardiac-rehabilitation-in-acute-myocardial-infarction-patients-after-percutaneous-coronary-intervention-a-community-based-study
#5
Yong Zhang, HongXia Cao, Pin Jiang, HaiQin Tang
BACKGROUND: Acute myocardial infarction (AMI) is one of the leading causes of death and physical disability worldwide. However, the development of community- based cardiac rehabilitation (CR) in AMI patients is hysteretic. Here, we aimed to evaluate the safety and efficacy of CR applied in the community in AMI patients who underwent percutaneous coronary intervention (PCI). METHODS: A total of 130 ST-segment elevated myocardial infarction (STEMI) patients after PCI were randomly divided into 2 groups in the community, rehabilitation group (n = 65) and control group (n = 65)...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29465292/an-unusual-case-of-sudden-cardiac-death-during-sexual-intercourse
#6
Cristina Mondello, Elvira Ventura Spagnolo, Luigi Cardia, Orazio Ventura Spagnolo, Patrizia Gualniera, Antonina Argo
The most common cause of sudden death during sexual intercourse in adults is heart disease, and it is usually the male, whereas the death of the woman is unusual. Generally, in these cases, death occurs as a result of cardiovascular disease. The authors report an unusual case of the sudden death of a young woman during sexual intercourse. The post-mortem investigations (autopsy, cardiac nuclear magnetic resonance and cardiac histology) demonstrated a previously undiagnosed arrhythmogenic right ventricular cardiomyopathy...
January 1, 2018: Medico-legal Journal
https://www.readbyqxmd.com/read/29465201/-pulse-wave-transit-time-one-more-attempt-of-non-invasive-cardiac-output-measurement
#7
B A Akselrod, L A Tolstova, T A Pshenichniy, S V Fedulova
BACKGROUND: Estimated continuous cardiac output (esCCOTM) based on pulse wave transit time is one of alternative non-invasive CO measurement techniques. METHODS: Randomized study included 23 scheduled patients operated upon due to cardiovascular diseases. Cardiac index (CI) was measured Comparative analyses of esCCO and others CO measurement methods used intraoperative was carried out. In the first group (n = 9) esCCO was compared with transpulmonary thermodilution (PiCCO-plus); in the second group (n = 8) - with pulmonary artery thermodilution; in the third group (n = 6) - with transoesophageal echocardiography (velocity-time integral)...
September 2017: Anesteziologiia i Reanimatologiia
https://www.readbyqxmd.com/read/29464142/decreased-renal-function-is-associated-with-elevated-cha2ds2vasc-and-r2chads2-scores-in-non-valvular-atrial-fibrillation-patients-presenting-with-stroke
#8
Mohinder Vindhyal, Shravani R Vindhyal, Travis Haneke, Paul M Ndunda, Freidy Eid, K James Kallail
Introduction Atrial fibrillation (AF), the most common cardiac arrhythmia, affects approximately 2.3 million patients in the United States, costing around $26 billion. Atrial fibrillation is associated with a two- to seven-fold increased risk of stroke, one of the most serious complications. Chronic kidney disease affects approximately 13% of the US population and has been associated with higher rates of AF than the general population. In patients with chronic kidney disease (CKD), the risk of stroke increases as the glomerular filtration rate (GFR) decreases, especially in CKD stages three and four...
December 11, 2017: Curēus
https://www.readbyqxmd.com/read/29461006/left-ventricular-geometric-patterns-in-end-stage-kidney-disease-determinants-and-course-over-time
#9
Menso J Nubé, Tiny Hoekstra, Volkan Doganer, Michiel L Bots, Peter J Blankestijn, Marinus van den Dorpel, Otto Kamp, Piet M Ter Wee, Camiel L M de Roij van Zuijdewijn, Muriel P C Grooteman
INTRODUCTION: While concentric left ventricular hypertrophy (cLVH) predominates in non-dialysis-dependent chronic kidney disease (CKD), eccentric left ventricular hypertrophy (eLVH) is most prevalent in dialysis-dependent CKD stage 5 (CKD5D). In these patients, the risk of sudden death is 5× higher than in individuals with cLVH. Currently, it is unknown which factors determine left ventricular (LV) geometry and how it changes over time in CKD5D. METHODS: Data from participants of the CONvective TRAnsport Study who underwent serial transthoracic echocardiography were used...
February 20, 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29460602/kardial-sarkoidose
#10
Jens Vikse, Stein Ørn, Bas Jeroen de Romijn, Ole Jacob Greve, Katrine Brække Norheim
Sarcoidosis is characterised by granulomatous inflammation in one or more organs, including the heart. Cardiac sarcoidosis generally has non-specific symptoms, and the disease is often diagnosed at a late stage. The condition is associated with cardiomyopathy and arrhythmia and may be fatal.
February 19, 2018: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/29460366/ejection-fraction-as-a-statistical-index-of-left-ventricular-systolic-function-the-first-full-allometric-scrutiny-of-its-appropriateness-and-accuracy
#11
Lorenzo Lolli, Alan M Batterham, Greg Atkinson
Left ventricular ejection fraction (EF) is a ratio that is deemed to accurately normalize stroke volume (SV) to end-diastolic volume (EDV). Ratios are now well-recognized for not normalizing the numerator, in this case SV, consistently for the denominator, EDV. We aimed to provide the first allometric-based scrutiny of the conventional assumptions that underpin the EF ratio. We allometrically modelled untransformed SV and EDV measurements from 112 preclinical heart failure patients in the Multi-Ethnic Study of Atherosclerosis (MESA), and 864 chronic heart failure patients in the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) study...
February 20, 2018: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/29460150/ph-modulation-of-voltage-gated-sodium-channels
#12
Colin H Peters, Mohammad-Reza Ghovanloo, Cynthia Gershome, Peter C Ruben
Changes in blood and tissue pH accompany physiological and pathophysiological conditions including exercise, cardiac ischemia, ischemic stroke, and cocaine ingestion. These conditions are known to trigger the symptoms of electrical diseases in patients carrying sodium channel mutations. Protons cause a diverse set of changes to sodium channel gating, which generally lead to decreases in the amplitude of the transient sodium current and increases in the fraction of non-inactivating channels that pass persistent currents...
February 20, 2018: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/29459363/the-failing-heart-stimulates-tumor-growth-by-circulating-factors
#13
Wouter C Meijers, Manuel Maglione, Stephan J L Bakker, Rupert Oberhuber, Lyanne M Kieneker, Steven de Jong, Bernhard J Haubner, Wouter B Nagengast, Alexander R Lyon, Bert van der Vegt, Dirk J van Veldhuisen, B Daan Westenbrink, Peter van der Meer, Herman H W Silljé, Rudolf A de Boer
Background -Heart failure (HF) survival has improved and nowadays many patients with HF die from non-cardiac causes, including cancer. Our aim was to investigate whether a causal relationship exists between HF and the development of cancer. Methods -HF was induced by inflicting large anterior myocardial infarction (MI) in APCmin mice, which are prone to develop precancerous intestinal tumors, and tumor growth was measured. In addition, to rule out hemodynamic impairment, a heterotopic heart transplantation model was employed, where an infarcted or sham-operated heart was transplanted into a recipient mouse, while the native heart was left in situ...
February 19, 2018: Circulation
https://www.readbyqxmd.com/read/29457116/a-spinal-cord-infarction-that-occurred-after-laparoscopic-gastrectomy-performed-under-general-anesthesia-and-epidural-analgesia
#14
Kei Houri, Shinichi Hamasaki, Takatoshi Tsujimoto, Tomohisa Uchida, Tatsushige Iwamoto, Toru Shirai, Shinichi Nakao
Background: Spinal cord infarction (SCI) after epidural anesthesia is quite rare. Although most cases of perioperative SCI are associated with aortic, cardiac, or spinal surgery, and/or abnormal preoperative conditions, such as spinal stenosis or hypercoagulopathy, intraoperative events, such as severe hypotension or epidural puncture and catheterization, can be contributory factors. Case presentation: A 52-year-old male was underwent laparoscopic gastrectomy. Before induction of general anesthesia, an epidural catheter was placed without any problems...
2018: JA Clin Rep
https://www.readbyqxmd.com/read/29456629/acute-vitamin-c-improves-cardiac-function-not-exercise-capacity-in-adults-with-type-2-diabetes
#15
Rebecca L Scalzo, Timothy A Bauer, Kylie Harrall, Kerrie Moreau, Cemal Ozemek, Leah Herlache, Shawna McMillin, Amy G Huebschmann, Jennifer Dorosz, Jane E B Reusch, Judith G Regensteiner
Background: People with type 2 diabetes (T2D) have impaired exercise capacity, even in the absence of complications, which is predictive of their increased cardiovascular mortality. Cardiovascular dysfunction is one potential cause of this exercise defect. Acute infusion of vitamin C has been separately shown to improve diastolic and endothelial function in prior studies. We hypothesized that acute vitamin C infusion would improve exercise capacity and that these improvements would be associated with improved cardiovascular function...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29455769/prevention-of-sudden-cardiac-death-in-athletes-sportspersons-and-marathoners-in-india
#16
REVIEW
Amit Vora, Nitin Burkule, Ashish Contractor, Kartikeya Bhargava
The annual incidence of sudden cardiac death (SCD) in athletes is significantly lower than the general population. However, when SCD occurs in an athlete during sporting event or training, it sends shockwaves in the society and raises questions about cardiovascular effects of sports and exercise. This document reviews the causes and mechanism of SCD in sports and exercise in young and older athletes. In the Indian context, we suggest a 'pre-participation screening' of young and older athletes and consider a 'supervised, graded exercise regime' for the uninitiated, older sports participant...
January 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29455061/relationship-between-nurse-staffing-level-and-adult-nursing-sensitive-outcomes-in-tertiary-hospitals-of-korea-retrospective-observational-study
#17
Chul-Gyu Kim, Kyun-Seop Bae
BACKGROUND: Nurse staffing level is an important factor on nursing sensitive outcome. The relationships of nurse staffing level with nursing sensitive outcomes such as mortality, upper gastrointestinal bleeding and pressure ulcer have been explored in the United States, Canada, Australia, and New Zealand. Lower level of hospital nurse staffing seems associated with more adverse outcomes, especially mortality. However, there is insufficient evidence of the nurse staffing level-outcome relationship in other indicators...
January 2, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29454656/rhythm-and-orthopedics-the-effect-of-music-therapy-in-cast-room-procedures-a-prospective-clinical-trial
#18
Tolga Tolunay, Vedat Bicici, Hatice Tolunay, Mehmet Orcun Akkurt, Arslan Kagan Arslan, Ali Aydogdu, Izzet Bingol
INTRODUCTION: Cast room procedures generally cause anxiety in patients. Anxiety complicates the procedure as well as increases the risk of a complication. Listening to music was found to be the safest and most common non-drug treatment method. The aim of this study is to evaluate the effect of listening to music on adult patients in cast room procedures. This study points out the relation between anxiety and anxiety relevant cardiac arrhythmia. MATERIALS AND METHODS: The study was performed on 199 patients with stable general condition, aged above 18...
February 7, 2018: Injury
https://www.readbyqxmd.com/read/29454286/the-vasodilatory-effect-of-allopurinol-mediates-its-antihypertensive-effect-effects-on-calcium-movement-and-cardiac-hemodynamics
#19
Hany M El-Bassossy, Mona F Mahmoud, Basma G Eid
Despite the reported reduction in blood pressure in hypertensive patients treated with allopurinol, the mechanism of the allopurinol hypotensive effect is still unclear. In the current study, the hypotensive effect of allopurinol has been fully investigated in hypertensive rats. Hypertension was induced in rats by angiotensin II (120 ng/min/kg) infusion for two weeks. Rats were then subjected to real-time recording of blood pressure, left ventricular pressure and volume and surface ECG. After 10 min of basal recording, allopurinol was slowly injected into the femoral vein with a dose of 10 μmole/kg...
February 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29452806/steroid-administration-after-anaesthetic-induction-with-etomidate-does-not-reduce-in-hospital-mortality-or-cardiovascular-morbidity-after-non-cardiac-surgery
#20
R Komatsu, J You, S Rajan, Y Kasuya, D I Sessler, A Turan
BACKGROUND: We tested the primary hypothesis that corticosteroid administration after etomidate exposure reduces a composite of in-hospital mortality and cardiovascular morbidity after non-cardiac surgery. METHODS: We evaluated ASA physical status III and IV patients who had non-cardiac surgery with general anaesthesia at the Cleveland Clinic. Amongst 4275 patients in whom anaesthesia was induced with etomidate, 804 were also given steroid intraoperatively, mostly dexamethasone at a median dose of 6 mg...
March 2018: British Journal of Anaesthesia
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