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Vaginal progesterone

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https://www.readbyqxmd.com/read/28729911/vaginal-progesterone-to-reduce-preterm-birth-among-hiv-infected-pregnant-women-in-zambia-a-feasibility-study-protocol
#1
Joan T Price, Katie R Mollan, Nurain M Fuseini, Bethany L Freeman, Helen B Mulenga, Amanda H Corbett, Bellington Vwalika, Jeffrey S A Stringer
BACKGROUND: Women infected with HIV have a risk of preterm birth (PTB) that is twice that among uninfected women, and treatment with antiretroviral therapy (ART) may further increase this risk. Progesterone supplementation reduces the risk of preterm delivery in women who have a shortened cervix in the midtrimester. We propose to study the feasibility of a trial of vaginal progesterone (VP) to prevent PTB among HIV-infected women receiving ART in pregnancy. Given low adherence among women self-administering vaginal study product in recent microbicide trials, we plan to investigate whether adequate adherence to VP can be achieved prior to launching a full-scale efficacy trial...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28708535/comparison-of-estrus-synchronization-by-controlled-internal-drug-release-device-cidr-and-adhesive-transdermal-progestin-patch-in-postpartum-beef-cows
#2
Jatuporn Kajaysri, Chaiwat Chumchoung, Supphathat Wutthiwitthayaphong, Wanvipa Suthikrai, Praphai Sangkamanee
Estrous synchronization with progesterone based protocols has been essentially used in cattle industry. Although intravaginal devices have been commonly used, this technique may induce vaginitis. This study aimed at examining the efficiency of novel transdermal progestin patch on follicle development and comparing the progestin patch versus CIDR device on estrous synchronization, complication at treated site and pregnancy in beef cattle. In experiment 1, seven beef cows were treated with an adhesive transdermal progestin patch on the ventral surface of the proximal part of the tail for 7 days...
June 6, 2017: Theriogenology
https://www.readbyqxmd.com/read/28708519/relationships-between-uterine-health-and-metabolism-in-dairy-cows-with-different-dry-period-lengths
#3
J Chen, N M Soede, G J Remmelink, R M Bruckmaier, B Kemp, A T M van Knegsel
The first objective of this study was to evaluate effects of dry period (DP) length and dietary energy source on ovarian activity, uterine health status, pregnancy rate, and days open in dairy cows in the second subsequent lactation after implementation of DP length and dietary treatments. The second objective was to determine relationships of uterine health status with ovarian activity, milk yield, energy balance (EB), and metabolic status in dairy cows. Holstein-Friesian dairy cows (n = 167) were assigned randomly to 1 of 3 DP lengths (0-, 30-, or 60-d) and 1 of 2 early lactation diets (glucogenic or lipogenic diet) for 2 subsequent lactations...
June 13, 2017: Theriogenology
https://www.readbyqxmd.com/read/28707771/effect-of-vaginal-progesterone-in-tocolytic-therapy-during-preterm-labor-in-twin-pregnancies-secondary-analysis-of-a-placebo-controlled-randomized-trial
#4
Wagner R Hernandez, Rossana P V Francisco, Roberto E Bittar, Ursula T Gomez, Marcelo Zugaib, Maria L Brizot
AIM: Our aim was to investigate the effect of the prophylactic use of vaginal progesterone on the latency period from the initiation of tocolytic therapy to delivery in twin pregnancies with preterm labor. METHODS: This study was a secondary analysis of a randomized, double-blind, placebo-controlled trial of twin pregnancies in mothers who were exposed to a 200 mg vaginal progesterone ovule or a placebo ovule daily from 18 to 34 weeks gestation. Patients who were administered tocolysis with Atosiban because of preterm labor were included...
July 14, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28596011/emmenagogue-properties-of-milicia-excelsa-welw-c-c-berg-moraceae-based-at-least-in-part-on-its-ability-to-correlate-the-activity-of-the-hypothalamic-pituitary-axis-to-that-of-the-ovaries
#5
Marie Alfrede Mvondo, Aude Jaelle Touomo Sakock, Sylvin Benjamin Ateba, Charline Florence Awounfack, Telesphore Nanbo Gueyo, Dieudonné Njamen
ETHNOPHARMACOLOGICAL RELEVANCE: Milicia excelsa (Welw.) C.C. Berg (Moraceae) is a medicinal plant recommended over tropical Africa as a cure for several ailments including amenorrhea. This is the hallmark of an ovarian lesion or a dysfunction of the hypothalamic-pituitary-ovarian axis which may lead to infertility, osteoporosis or endometrial cancer. However, regardless these traditional claims, no scientific report dealing with emmenagogue properties has been reported yet. AIM OF THE STUDY: To bring scientific evidence to the curative action of the plant, we proposed evaluating the effects of a root aqueous extract of Milicia excelsa on female Wistar rat sexual maturation...
July 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28594783/progestogens-for-maintenance-tocolysis-in-women-with-a-short-cervix-a-randomized-controlled-trial
#6
Fabio Facchinetti, Patrizia Vergani, Mariarosaria Di Tommaso, Luca Marozio, Barbara Acaia, Roberto Vicini, Lucrezia Pignatti, Anna Locatelli, Marina Spitaleri, Chiara Benedetto, Barbara Zaina, Roberto DʼAmico
OBJECTIVE: To assess the efficacy of progestogens for maintenance tocolysis in women undelivered after their first preterm labor episode. METHODS: Women with singleton pregnancies between 22 0/7 and 31 6/7 weeks of gestation with arrested preterm labor and a cervical length 25 mm or less at hospital discharge were eligible. Patients with a previous preterm birth were excluded. In a randomized controlled trial conducted in five university hospitals, women were randomized to receive vaginal progesterone (200 mg per day) or intramuscular 17α-hydroxyprogesterone caproate (341 mg per week) or to an observation groups (control group)...
July 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28586127/cervical-stitch-cerclage-for-preventing-preterm-birth-in-singleton-pregnancy
#7
REVIEW
Zarko Alfirevic, Tamara Stampalija, Nancy Medley
BACKGROUND: Cervical cerclage is a well-known surgical procedure carried out during pregnancy. It involves positioning of a suture (stitch) around the neck of the womb (cervix), aiming to give mechanical support to the cervix and thereby reduce risk of preterm birth. The effectiveness and safety of this procedure remains controversial. This is an update of a review last published in 2012. OBJECTIVES: To assess whether the use of cervical stitch in singleton pregnancy at high risk of pregnancy loss based on woman's history and/or ultrasound finding of 'short cervix' and/or physical exam improves subsequent obstetric care and fetal outcome...
June 6, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28585136/effect-and-underlying-mechanism-of-bu-shen-an-tai-recipe-on-ovarian-apoptosis-in-mice-with-controlled-ovarian-hyperstimulation-implantation-dysfunction
#8
Wen-Wen Ma, Jing Xiao, Yu-Fan Song, Jia-Hui Ding, Xiu-Juan Tan, Kun-Kun Song, Ming-Min Zhang
The effect and underlying mechanism of Bu-Shen-An-Tai recipe on ovarian apoptosis in mice with controlled ovarian hyperstimulation (COH) implantation dysfunction were studied. The COH implantation dysfunction model in mice was established by intraperitoneal injection of 7.5 IU pregnant mare's serum gonadotrophin (PMSG), followed by 7.5 IU human chorionic gonadotrophin (HCG) 48 h later. Then the female mice were mated with male at a ratio of 2:1 in the same cage at 6:00 p.m. The female mice from normal group were injected intraperitoneally with normal saline and mated at the corresponding time...
June 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28549981/early-pregnancy-vaginal-microbiome-trends-and-preterm%C3%A2-birth
#9
Molly J Stout, Yanjiao Zhou, Kristine M Wylie, Phillip I Tarr, George A Macones, Methodius G Tuuli
BACKGROUND: Despite decades of attempts to link infectious agents to preterm birth, an exact causative microbe or community of microbes remains elusive. Nonculture 16S ribosomal RNA gene sequencing suggests important racial differences and pregnancy specific changes in the vaginal microbial communities. A recent study examining the association of the vaginal microbiome and preterm birth documented important findings but was performed in a predominantly white cohort. Given the important racial differences in bacterial communities within the vagina as well as persistent racial disparities in preterm birth, it is important to examine cohorts with varied demographic compositions...
May 23, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28536048/cell-free-dna-inflammation-and-the-initiation-of%C3%A2-spontaneous-term-labor
#10
Christina A Herrera, Jay Stoerker, John Carlquist, Gregory J Stoddard, Marc Jackson, Sean Esplin, Nancy C Rose
BACKGROUND: Hypomethylated cell-free DNA from senescent placental trophoblasts may be involved in the activation of the inflammatory cascade to initiate labor. OBJECTIVE: To determine the changes in cell-free DNA concentrations, the methylation ratio, and inflammatory markers between women in labor at term vs women without labor. STUDY DESIGN: In this prospective cohort study, eligible participants carried a nonanomalous singleton fetus. Women with major medical comorbidity, preterm labor, progesterone use, aneuploidy, infectious disease, vaginal bleeding, abdominal trauma, or invasive procedures during the pregnancy were excluded...
May 20, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28502186/effectiveness-of-dydrogesterone-17-oh-progesterone-and-micronized-progesterone-in-prevention-of-preterm-birth-in-women-with-a-short-cervix
#11
Olga Pustotina
OBJECTIVE: To compare the efficacy of dydrogesterone, 17-OH progesterone (17OHP) and oral or vaginal micronized progesterone with cerclage for the prevention of preterm birth in women with a short cervix. METHODS: The study included 95 women with singleton gestation and cervical length (CL) ≤ 25 mm. Among these, 35 women were asymptomatic at 15-24 weeks and 60 had symptoms of threatened late miscarriage (LM) or preterm delivery (PD) at 15-32 weeks. Patients were randomized to receive dydrogesterone, 17OHP or oral/vaginal micronized progesterone; after one week of therapy 15 women underwent cerclage...
May 29, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28501869/intramuscular-versus-vaginal-progesterone-administration-in-medicated-frozen-embryo-transfer-cycles-a-randomized-clinical-trial-assessing-sub-endometrial-contractions
#12
Anat Hershko Klement, Nivin Samara, Amir Weintraub, Frederic Mitri, Yaakov Bentov, Paul Chang, Dan Nayot, Robert F Casper
OBJECTIVE: The study aimed to assess whether sub-endometrial contractility is reduced by the use of intramuscular (IM) progesterone. DESIGN: This is a randomized clinical trial. Patients assigned to a medicated day 5 frozen embryo transfer (FET) were randomly allocated to "vaginal progesterone" or "IM progesterone": patients randomized to the vaginal arm were treated with 200 mg micronized progesterone 3 times daily while patients randomized into the IM progesterone arm were treated with a single daily injection of 50 mg progesterone in oil...
May 13, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28484835/effectiveness-of-the-contemporary-treatment-of-preterm-labor-a-comparison-with-a-historical-cohort
#13
Philipp Wagner, Jiri Sonek, Harald Abele, Loefler Sarah, Markus Hoopmann, Sara Brucker, Qinging Wu, Karl Oliver Kagan
OBJECTIVE: To compare the effectiveness of contemporary treatment of preterm labor to a historical cohort. STUDY DESIGN: Retrospective matched case-control study to compare the outcomes of patients that were treated for preterm labor at the University Hospital of Tuebingen, Germany in 2014/2015 (current treatment cohort) and 2006/2007 (historical cohort). The study included women with singleton gestations who were admitted with the diagnosis of preterm labor between 24 + 0 and 34 + 0 weeks' gestation and a cervical length of ≤15 mm...
July 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28473770/pharmacokinetic-properties-of-three-forms-of-vaginal-progesterone-administered-in-either-single-or-multiple-dose-regimen-in-healthy-post-menopausal-chinese-women
#14
Guolan Wu, Junchun Chen, Xingjiang Hu, Huili Zhou, Jian Liu, Duo Lv, Lihua Wu, Jianzhong Shentu
Objective: A generic vaginal progesterone gel has recently been developed in China. Little is known about its pharmacokinetic properties in Chinese subjects. The purpose of our study was to investigate the pharmacokinetics of three forms of vaginal progesterone gel (test formulations at 4 and 8% strength vs. a reference formulation: Crinone 8%) in Chinese healthy post-menopausal women. Methods: This study consisted of two parts study. The part 1 study was a single-center, open-label, 3-period study. Twelve healthy post-menopausal women were to evaluate the safety and pharmacokinetics of 45 mg vaginal progesterone gel (Test 4%) following single dose and multiple doses administered once every other day (q...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28463909/fibroadenoma-like-lesion-of-the-vagina-a-description-of-2-cases-of-a-previously-unreported-entity
#15
Michelle Moore, Michael McKenna, Srinivas Mandavilli, W Glenn McCluggage
We report 2 cases of a previously undescribed vaginal lesion, which we term "fibroadenoma-like lesion of the vagina" because of the close morphologic resemblance to breast fibroadenoma. Both lesions arose in the upper vagina and exhibited a biphasic appearance with benign epithelial and stromal elements. The glandular epithelium comprised a double layer of luminal and basal cells with focal squamous differentiation in 1 case. The stromal component was fibroblastic and morphologically bland for the most part, although occasional atypical symplastic-like cells were present in 1 case...
April 29, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28462399/can-letrozole-plus-hmg-protocol-improve-pregnancy-outcomes-in-frozen-thawed-embryo-transfer-an-rct
#16
Ashraf Aleyasin, Marzieh Aghahosseini, Leili Safdarian, Maryam Noorzadeh, Parvin Fallahi, Zahra Rezaeian, Sedighe Hoseinimosa
BACKGROUND: There are different methods in endometrial preparation for frozen-thawed embryo transfer (FET). OBJECTIVE: The purpose of this study was to compare the live birth rate in the artificial FET protocol (estradiol/ progesterone with GnRH-agonist) with stimulated cycle FET protocol (letrozole plus HMG). MATERIALS AND METHODS: This randomized clinical trial included 100 women (18-42 years) randomly assigned to two groups based on Bernoulli distribution...
February 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28446940/a-case-of-disseminated-peritoneal-leiomyomatosis-after-two-laparoscopic-procedures-due-to-uterine-fibroids
#17
Michał Ciebiera, Aneta Słabuszewska-Jóźwiak, Kornelia Zaręba, Grzegorz Jakiel
Disseminated peritoneal leiomyomatosis (DPL) is a rare disorder characterized by the presence of multifocal nodules and tumors composed of proliferating smooth muscle tissue, spread throughout the peritoneum. Estrogens and progesterone are considered to be the main factors initiating the formation of disseminated leiomyomatosis. Disseminated peritoneal leiomyomatosis is often asymptomatic, and acyclic vaginal bleeding or pain in the lower abdomen is associated with leiomyomatous rebuilt uterus corpus. Disseminated peritoneal leiomyomatosis can have other ambiguous presentation...
2017: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/28444869/assessment-of-the-usage-of-biodegradable-polymeric-matrix-in-vaginal-devices-to-sustain-progesterone-release-in-cows
#18
José Rodrigo Valim Pimentel, Milton Maturana Filho, Lucio Cardozo-Filho, José Augusto M Agnelli, Jefter Nascimento, Ed Hoffmann Madureira
The usage of timed artificial insemination (TAI) at a low cost leading to better reproductive rates has been the aim of several research groups in the field. Usually during TAI protocols, sustained progesterone (P4 ) release devices are employed. Most devices are constituted of a nylon skeleton covered with a silicon layer with P4 . A device based on biopolymers was developed in order to reduce costs and decrease its environmental impact. In this study, we compared the kinetics of sustained progesterone release among devices manufactured with a polymeric blend made of polyhydroxybutyrate-valerate (PHBV) and poly-ε-caprolactone (PCL) (DISP) which were compared with DIB® (Internal Bovine Device) used as the control...
April 25, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28443690/vitrified-warmed-blastocyst-transfer-on-the-5th-or-7th-day-of-progesterone-supplementation-in-an-artificial-cycle-a-randomised-controlled-trial
#19
A van de Vijver, P Drakopoulos, N P Polyzos, L Van Landuyt, S Mackens, S Santos-Ribeiro, V Vloeberghs, H Tournaye, C Blockeel
Prospective studies comparing different durations of progesterone supplementation before transfer of vitrified-warmed blastocysts in an artificial cycle are lacking. However, in oocyte donation programmes, the sporadic available evidence demonstrates considerable differences in clinical pregnancy rates according to the duration of progesterone administration. This randomised controlled trial (RCT), included 303 patients undergoing a frozen-thawed embryo transfer (FET) of one or two vitrified-warmed blastocyst(s) in an artificial cycle...
April 26, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28439292/effects-of-bushen-tianjing-recipe-in-a-rat-model-of-tripterygium-glycoside-induced-premature-ovarian-failure
#20
Xiaofeng Xu, Yong Tan, Guorong Jiang, Xuanyi Chen, Rensheng Lai, Lurong Zhang, Guoqiang Liang
BACKGROUND: Bushen Tianjing Recipe (BTR) is a traditional Chinese herbal medicine that has been prescribed for premature ovarian failure (POF) for decades in China. Nevertheless, little is known regarding its underlying molecular mechanism. In the present study, we investigated the effects of BTR in a tripterygium glycoside (TG)-induced-POF rat model. METHODS: Three doses of BTR were administered via intragastric gavage to adult female Sprague-Dawley (SD) rats with TG-induced POF...
2017: Chinese Medicine
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