keyword
https://read.qxmd.com/read/38309681/gdnf-facilitates-the-differentiation-of-adscs-to-schwann-cells-and-enhances-nerve-regeneration-through-gdnf-mta1-hes1-axis
#21
JOURNAL ARTICLE
Weixia Cai, Yang Liu, Ting Zhang, Peng Ji, Chenyang Tian, Jiaqi Liu, Zhao Zheng
Adipose tissue-derived stem cells (ADSCs) are a kind of stem cells with multi-directional differentiation potential, which mainly restore tissue repair function and promote cell regeneration. It can be directionally differentiated into Schwann-like cells to promote the repair of peripheral nerve injury. Glial cell line-derived neurotrophic factor (GDNF) plays an important role in the repair of nerve injury, but the underlying mechanism remains unclear, which seriously limits its further application.The study aimed to identify the molecular mechanism by which overexpression of glial cell line-derived neurotrophic factor (GDNF) facilitates the differentiation of ADSCs into Schwann cells, enhancing nerve regeneration after injury...
February 1, 2024: Archives of Biochemistry and Biophysics
https://read.qxmd.com/read/38285310/notch-signaling-regulates-th17-cells-differentiation-through-pi3k-akt-mtorc1-pathway-and-involves-in-the-thyroid-injury-of-autoimmune-thyroiditis
#22
JOURNAL ARTICLE
C He, Y Li, L Gan, Y Lin, B Zhang, L Ma, H Xue
PURPOSE: Autoimmune Thyroiditis (AIT) is the most common thyroid disease; however, there were no measures to prevent the progression of the disease. The present study attempts to identify that Notch signaling regulates the differentiation of T helper 17 (Th17) cells by activating downstream Phosphatidylinositol-3 kinase/protein kinase/mechanistic target of rapamycin complex 1 (PI3K/AKT/mTORC1) pathway participating in the thyroid injury of the experimental autoimmune thyroiditis (EAT)...
January 29, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38279763/non-coding-rnas-as-key-regulators-of-the-notch-signaling-pathway-in-glioblastoma-diagnostic-prognostic-and-therapeutic-targets
#23
JOURNAL ARTICLE
Seyed Hossein Shahcheraghi, Elmira Roshani Asl, Malihe Lotfi, Jamshid Ayatollahi, Seyed Hossein Khaleghinejad, Alaa A Aljabali, Hamid A Bakshi, Mohamed El-Tanani, Nitin Charbe, Ángel Serrano-Aroca, Vijay Mishra, Yachana Mishra, Rohit Goyal, Altijana Hromić-Jahjefendić, Vladimir N Uversky, Marzieh Lotfi, Murtaza M Tambuwala
Glioblastoma multiforme (GBM) is a highly invasive brain malignancy originating from astrocytes, accounting for approximately 30% of central nervous system malignancies. Despite advancements in therapeutic strategies including surgery, chemotherapy, and radiopharmaceutical drugs, the prognosis for GBM patients remains dismal. The aggressive nature of GBM necessitates the identification of molecular targets and the exploration of effective treatments to inhibit its proliferation. The Notch signaling pathway, which plays a critical role in cellular homeostasis, becomes deregulated in GBM, leading to increased expression of pathway target genes such as MYC, Hes1, and Hey1, thereby promoting cellular proliferation and differentiation...
January 24, 2024: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/38247878/tgf%C3%AE-and-hippo-signaling-pathways-coordinate-to-promote-acinar-to-ductal-metaplasia-in-human-pancreas
#24
JOURNAL ARTICLE
Michael Nipper, Yi Xu, Jun Liu, Xue Yin, Zhijie Liu, Zhengqing Ye, Jianmin Zhang, Yidong Chen, Pei Wang
BACKGROUND & AIMS: Acinar-to-ductal metaplasia (ADM) serves as a precursor event in the development of pancreatic ductal adenocarcinoma (PDAC) upon constitutive environmental and genetical stress. While the role of ADM in PDAC progression has been established, the molecular mechanisms underlying human ADM remain elusive. We previously demonstrated the induction of ADM in human acinar cells through the transforming growth factor beta (TGFβ) signaling pathway. We aim to investigate the interaction between TGFβ and Hippo pathways in mediating ADM...
January 18, 2024: Cells
https://read.qxmd.com/read/38246005/role-of-cytokines-and-th17-tregs-imbalance-in-the-pathogenesis-of-otitis-media-with-effusion-modulation-of-notch1-hes1-mtorc1-s6k1-signalling-pathway-underlies-the-protective-effect-of-astaxanthin
#25
JOURNAL ARTICLE
Noura Mostafa Mohamed, Amira Mohamed Abdelhamid, Mohamed Aref, Marwa Abdelhafeez, Hadil Faris Alotabi, Doaa Sayed Mohammed Abdelrahman, Nisreen E Elwany
UNLABELLED: Otitis media with effusion (OME) is a recurrent middle ear inflammatory condition. It may be complicated by acquired hearing loss and speech impairment especially in children. Accordingly, the current study aimed to assess the role of cytokines and the imbalance of Th17/Tregs in the pathogenesis of OME. Additionally, the protective effect of astaxanthin and its mechanisms related to Notch1/ Hes1/mTORC1/S6K1 signalling were investigated. METHODS: Forty-eight children were grouped as follow: G1: control healthy group G2: acute otitis media (AOM) group, G3: OME group...
January 19, 2024: International Immunopharmacology
https://read.qxmd.com/read/38243869/linc-mir503hg-controls-sc-%C3%AE-cell-differentiation-and-insulin-production-by-targeting-cdh1-and-hes1
#26
JOURNAL ARTICLE
Yang Xu, Susu Mao, Haowen Fan, Jian Wan, Lin Wang, Mingyu Zhang, Shajun Zhu, Jin Yuan, Yuhua Lu, Zhiwei Wang, Bin Yu, Zhaoyan Jiang, Yan Huang
Stem cell-derived pancreatic progenitors (SC-PPs), as an unlimited source of SC-derived β (SC-β) cells, offers a robust tool for diabetes treatment in stem cell-based transplantation, disease modeling, and drug screening. Whereas, PDX1+ /NKX6.1+ PPs enhances the subsequent endocrine lineage specification and gives rise to glucose-responsive SC-β cells in vivo and in vitro. To identify the regulators that promote induction efficiency and cellular function maturation, single-cell RNA-sequencing is performed to decipher the transcriptional landscape during PPs differentiation...
January 20, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38242426/the-notch1-hes1-pathway-regulates-neuregulin-1-erbb4-and-participates-in-microglial-activation-in-rats-with-vpa-induced-autism
#27
JOURNAL ARTICLE
Yanan Deng, Liping Ma, Ziwei Du, Huixin Ma, Yuxi Xia, Liran Ping, Zhaoxing Chen, Yinghua Zhang
The core clinical characteristics of autism, which is a neurodevelopmental disease, involve repetitive behavior and impaired social interactions. Studies have shown that the Notch and Neuregulin1 (NRG1) signaling pathways are abnormally activated in autism, but the mechanism by which these two signaling pathways interact to contribute to the progression of autism has not been determined. Our results suggest that the levels of Notch1, Hes1, NRG1, and phosphorylated ErbB4 in the cerebellum (CB), hippocampus (HC), and prefrontal cortex (PFC) were increased in rats with valproic acid (VPA)-induced autism compared to those in the Con group...
January 17, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38228236/spindle-and-kinetochore-related-complex-subunit-3-has-a-protumour-function-in-osteosarcoma-by-activating-the-notch-pathway
#28
JOURNAL ARTICLE
Gaofeng Liang, Chaopeng Duan, June He, Liang Shi
Increasing expression of spindle and kinetochore-related complex subunit 3 (SKA3) is related to the progression of multiple malignancies. However, the role of SKA3 in osteosarcoma remains unexplored. The present study aimed to investigate the relevance of SKA3 in osteosarcoma. Preliminarily, SKA3 expression in osteosarcoma was assessed through The Cancer Genome Atlas (TCGA) analysis, which revealed high levels of SKA3 transcripts in osteosarcoma tissues. Subsequent examination of clinical tissues confirmed the abundant expression of SKA3 in osteosarcoma...
January 14, 2024: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/38227267/bhlh-transcription-factors-hes1-ascl1-and-oligo2-exhibit-different-expression-patterns-in-the-process-of-physiological-electric-fields-induced-neuronal-differentiation
#29
JOURNAL ARTICLE
Zhe Li, Hai Li, Xiyao Yu, Jiaying Zhou, Zhi Yong Dong, Xiaoting Meng
BACKGROUND: Recent studies have shown that the expression of bHLH transcription factors Hes1, Ascl1, and Oligo2 has an oscillating balance in neural stem cells (NSCs) to maintain their self-proliferation and multi-directional differentiation potential. This balance can be disrupted by exogenous stimulation. Our previous work has identified that electrical stimulation could induce neuronal differentiation of mouse NSCs. METHODS: To further evaluate if physiological electric fields (EFs)-induced neuronal differentiation is related to the expression patterns of bHLH transcription factors Hes1, Ascl1, and Oligo2, mouse embryonic brain NSCs were used to investigate the expression changes of Ascl1, Hes1 and Oligo2 in mRNA and protein levels during EF-induced neuronal differentiation...
January 16, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38205203/does-subtyping-of-high-grade-pulmonary-neuroendocrine-carcinomas-have-an-impact-on-therapy-selection
#30
JOURNAL ARTICLE
Helmut Popper, Luka Brcic, Sylvia Eidenhammer
BACKGROUND: Small cell lung cancer (SCLC) and large cell neuroendocrine carcinomas (LCNEC) are characterized by a rapid progressive course. Therapy for SCLC has not much changed for decades, and in LCNEC controversies exist, favoring either SCLC-like or non-small cell lung cancer (NSCLC)-like therapy. Three subtypes of SCLC identified in cell cultures, namely ASCL1, NeuroD1, and POU2F3 have been confirmed by immunohistochemistry. The fourth type based on the expression of YAP1 was questioned, and another type, inflamed SCLC, was proposed...
December 26, 2023: Translational Lung Cancer Research
https://read.qxmd.com/read/38186196/studies-on-the-effect-and-mechanism-of-cd147-on-melanoma-stem-cells
#31
JOURNAL ARTICLE
Yuan Jiang, Renyi Liang, Liqun Li, Jian Guan
BACKGROUND: Melanoma is the most aggressive form of skin cancer. Melanoma stem cells (MSCs) are one of the driving forces of melanoma invasion and metastasis. Therefore, it is of great significance to explore the mechanisms that maintain the stemness of MSCs. In this study, CD147-positive (CD147+) MSCs derived from A375 cell line were characterized. METHODS: Side population (SP) and non-SP cells were sorted from A375 cells. Quantitative real-time polymerase chain reaction and Western blot analysis were conducted to determine the expression of CD147 in SP and non-SP cells...
2024: Allergologia et Immunopathologia
https://read.qxmd.com/read/38159855/notch2-promotes-osteoclast-maturation-and-metabolism-and-modulates-the-transcriptome-profile-during-osteoclastogenesis
#32
JOURNAL ARTICLE
Ernesto Canalis, Lauren Schilling, Jungeun Yu, Emily Denker
Notch signaling plays a key regulatory role in bone remodeling and NOTCH2 enhances osteoclastogenesis, an effect that is mostly mediated by its target gene Hes1. In the present study, we explored mechanisms responsible for the enhanced osteoclastogenesis in bone marrow derived macrophages (BMM) from Notch2tm1.1Ecan , harboring a NOTCH2 gain-of-function mutation, and control mice. Notch2tm1.1Ecan mice are osteopenic and have enhanced osteoclastogenesis. Bulk RNA-Seq and gene set enrichment analysis (GSEA) of Notch2tm1...
December 28, 2023: Journal of Biological Chemistry
https://read.qxmd.com/read/38133658/carvedilol-attenuates-inflammatory-reactions-of-lipopolysaccharide-stimulated-bv2-cells-and-modulates-m1-m2-polarization-of-microglia-via-regulating-nlrp3-notch-and-ppar-%C3%AE-signaling-pathways
#33
JOURNAL ARTICLE
Mohammadjavad Khoshnavay Foumani, Keyvan Amirshahrokhi, Zeinab Namjoo, Ali Niapour
Microglial cells coordinate immune responses in the central nervous system. Carvedilol (CVL) is a non-selective β-blocker with anti-inflammatory and anti-oxidant effects. This study aims to investigate the anti-inflammatory effects and the underlying mechanisms of CVL on lipopolysaccharide (LPS)-induced inflammation in microglial BV2 cells. BV2 cells were stimulated with LPS, and the protective effects of CVL were investigated via measurement of cell viability, reactive oxygen species (ROS), and interleukin (IL)-1β liberation...
December 22, 2023: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38125020/scfas-switch-stem-cell-fate-through-hdac-inhibition-to-improve-barrier-integrity-in-3d-intestinal-organoids-from-patients-with-obesity
#34
JOURNAL ARTICLE
Mona Farhadipour, Kaline Arnauts, Mathias Clarysse, Theo Thijs, Kathrin Liszt, Bart Van der Schueren, Laurens J Ceulemans, Ellen Deleus, Matthias Lannoo, Marc Ferrante, Inge Depoortere
Stem cells are a keystone of intestinal homeostasis, but their function could be shifted during energy imbalance or by crosstalk with microbial metabolites in the stem cell niche. This study reports the effect of obesity and microbiota-derived short-chain fatty acids (SCFAs) on intestinal stem cell (ISC) fate in human crypt-derived intestinal organoids (enteroids). ISC fate decision was impaired in obesity, resulting in smaller enteroids with less outward protruding crypts. Our key finding is that SCFAs switch ISC commitment to the absorptive enterocytes, resulting in reduced intestinal permeability in obese enteroids...
December 15, 2023: IScience
https://read.qxmd.com/read/38116559/nbp-cytoprotective-effects-promoting-neuronal-differentiation-in-bmscs-by-inhibiting-the-p65-hes1-pathway
#35
JOURNAL ARTICLE
Eryi Zhao, Peijian Huang, Zhongyan Zhao, Shixiong Huang, Shijun Hu, Ling Xie, Jie Lin, Daimei Wang
BACKGROUND: Bone marrow-derived mesenchymal stem cell (BMSC) transplantation has become an effective method for treating neurodegenerative diseases. OBJECTIVES: This study investigated the effect of 3-N-butylphthalide (NBP) on the neuronal differentiation of BMSCs and its potential mechanism. METHODS: In this study, a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was performed to detect cell proliferation and terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) staining was conducted to detect the apoptosis of BMSCs...
2023: Iranian Journal of Pharmaceutical Research: IJPR
https://read.qxmd.com/read/38101160/ectopic-expression-of-tumor-suppressive-mir-181c-5p-downregulates-oncogenic-notch-signaling-in-mda-mb-231-cells
#36
JOURNAL ARTICLE
Mohd Shuaib, Shashank Kumar
Triple negative breast cancer (TNBC) is a very invasive subtype of breast cancer (BCa), this is accounted for 15-20% of all BCa cases. TNBC patients have very limited therapy option due to lack of effective targets and patients shows the worse survival. Therefore, present study has tried to introduce the target based therapy by studying the tumor suppressive role of miR-181c-5p on oncogenic Notch1 signaling. Transient transfection, bioinformatics, qRT-PCR, Notch1 luciferase assay and western blotting techniques were utilized to study the effect of induced expression of miR-181c-5p on oncogenic Notch1 signaling in MDA-MB-231 cells...
December 6, 2023: Pathology, Research and Practice
https://read.qxmd.com/read/38096983/a-complex-interplay-between-notch-effectors-and-%C3%AE-catenin-signaling-in-morular-differentiation-of-endometrial-carcinoma-cells
#37
JOURNAL ARTICLE
Ako Yokoi, Akari Murayama, Miki Hashimura, Yasuko Oguri, Yohei Harada, Naomi Fukagawa, Misato Hayashi, Mototsugu Ono, Kensuke Ohhigata, Makoto Saegusa
Notch signaling contributes to tissue development and homeostasis, but little is known about its roles in morular differentiation of endometrial carcinoma (Em Ca) cells. The current study focused on crosstalk between Notch and β-catenin signaling in Em Ca with morules. Promoters of hairy and enhancer of split 1 (Hes1) and mastermind-like 2 (MAML2) were activated by Notch intracellular domain 1 but not β-catenin; we also observed a positive feedback loop between Hes1 and MAML2. Immunoreactivities for nuclear β-catenin, Hes1, and MAML2, as well as the interaction between β-catenin and Hes1 or MAML2, were significantly higher in morular lesions compared with surrounding carcinoma in Em Ca...
December 12, 2023: American Journal of Pathology
https://read.qxmd.com/read/37983663/transplantation-of-wnt3a-modified-neural-stem-cells-promotes-neural-regeneration-and-functional-recovery-after-spinal-cord-injury-via-wnt-gli2-pathway
#38
JOURNAL ARTICLE
Jiezhao Lin, Yucong Lin, Shuangfang Zhu, Jinzhou Luo, Chusong Zhou
Neural stem cell (NSCs) transplantation has great potential in the treatment of spinal cord injury (SCI). Previous studies have indicated that the Wnt pathway could regulate the expression of basic helix-loop-helix (bHLH) family factor Hes5 and Mash1 in NSCs, but not through the notch intracellular domain. This suggests that there are other signals involved in this process. The aim of this study was to investigate the role of Wnt-Gli2 pathway in the treatment of SCI by transplanting neural stem cells. NSCs were isolated from the striata of embryonic day 14 mice...
January 3, 2024: Neuroreport
https://read.qxmd.com/read/37971144/defining-the-relationship-of-salivary-gland-malignancies-to-novel-cell-subpopulations-in-human-salivary-glands-using-single-nucleus-rna-sequencing
#39
JOURNAL ARTICLE
Takuya Nakagawa, Jessica Santos, Chanond A Nasamran, Prakriti Sen, Sayed Sadat, Abdula Monther, Joseph Bendik, Koji Ebisumoto, Jingjing Hu, Sebastian Preissl, Theresa Guo, Vera Vavinskaya, Kathleen M Fisch, Joseph A Califano
Salivary glands have essential roles in maintaining oral health, mastication, taste and speech, by secreting saliva. Salivary glands are composed of several types of cells, and each cell type is predicted to be involved in the carcinogenesis of different types of cancers including adenoid cystic carcinoma (ACC), acinic cell carcinoma (AciCC), salivary duct carcinoma (SDC), myoepithelial carcinoma (MECA) and other histology. In our study, we performed single nucleus RNA-seq on three human salivary gland samples to clarify the gene expression profile of each complex cellular component of the salivary glands and related these expression patterns to expression found in salivary gland cancers (SGC) to infer cell of origin...
November 16, 2023: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/37957183/hes1-promotes-aerobic-glycolysis-and-cancer-progression-of-colorectal-cancer-via-igf2bp2-mediated-glut1-m6a-modification
#40
JOURNAL ARTICLE
Jiayu Wang, Mengxin Zhu, Jinghan Zhu, Juntao Li, Xingchao Zhu, Kun Wang, Kanger Shen, Kexi Yang, Xiangyu Ni, Xin Liu, Guangbo Zhang, Qinhua Xi, Tongguo Shi, Weichang Chen
Aerobic glycolysis has been shown to play a key role in tumor cell proliferation and metastasis. However, how it is directly regulated is largely unknown. Here, we found that HES1 expression was significantly higher in CRC tissues than that in adjacent normal tissues. Moreover, high HES1 expression is associated with poor survival in CRC patients. HES1 knockdown markedly inhibited cell growth and metastasis both in vitro and in vivo. Additionally, silencing of HES1 suppressed aerobic glycolysis of CRC cells...
November 13, 2023: Cell Death Discovery
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