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https://www.readbyqxmd.com/read/29665790/the-oncogenic-effects-of-hes1-on-salivary-adenoid-cystic-carcinoma-cell-growth-and-metastasis
#1
Xiao-Yu Huang, Rui-Huan Gan, Jian Xie, Lin She, Yong Zhao, Lin-Can Ding, Bo-Hua Su, Da-Li Zheng, You-Guang Lu
BACKGROUND: Our previous study demonstrated a close relationship between NOTCH signaling pathway and salivary adenoid cystic carcinoma (SACC). HES1 is a well-known target gene of NOTCH signaling pathway. The purpose of the present study was to further explore the molecular mechanism of HES1 in SACC. METHODS: Comparative transcriptome analyses by RNA-Sequencing (RNA-Seq) were employed to reveal NOTCH1 downstream gene in SACC cells. Immunohistochemical staining was used to detect the expression of HES1 in clinical samples...
April 17, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29658965/a-comprehensive-transcriptome-analysis-of-skeletal-muscles-in-two-polish-pig-breeds-differing-in-fat-and-meat-quality-traits
#2
Katarzyna Piórkowska, Kacper Żukowski, Katarzyna Ropka-Molik, Mirosław Tyra, Artur Gurgul
Pork is the most popular meat in the world. Unfortunately, the selection pressure focused on high meat content led to a reduction in pork quality. The present study used RNA-seq technology to identify metabolic process genes related to pork quality traits and fat deposition. Differentially expressed genes (DEGs) were identified between pigs of Pulawska and Polish Landrace breeds for two the most important muscles (semimembranosus and longissimus dorsi). A total of 71 significant DEGs were reported: 15 for longissimus dorsi and 56 for semimembranosus muscles...
January 2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29620169/lutein-inhibits-proliferation-invasion-and-migration-of-hypoxic-breast-cancer-cells-via-downregulation-of-hes1
#3
Yuan Li, Yuekun Zhang, Xiaosa Liu, Mingchen Wang, Peng Wang, Jianbo Yang, Shanfeng Zhang
An intratumoral hypoxic microenvironment is frequently observed in solid tumors, including breast cancer. Lutein, a plant-derived compound and non-vitamin A carotenoid, has been demonstrated to possess multiple protective properties including anti-inflammation, anti-oxidative stress and antitumor effects. The main objective of the present research was to elucidate the involvement of lutein in the production of reactive oxygen species (ROS) under hypoxia, the activation of hairy and enhancer of split 1 (HES1), and the proliferation, invasion and migration of breast cancer cells...
March 23, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29619065/-lycium-barbarum-polysaccharide-promotes-maturation-of-dendritic-cell-via-notch-signaling-and-strengthens-dendritic-cell-mediated-t-lymphocyte-cytotoxicity-on-colon-cancer-cell-ct26-wt
#4
Wei Wang, Mingxing Liu, Yang Wang, Tao Yang, Dongsheng Li, Feng Ding, Hongzhi Sun, Guang Bai, Qing Li
Lycium barbarum polysaccharide (LBP) is the major function component of Lycium barbarum L. and has been previously reported to induce the phenotypic and functional maturation of dendritic cells (DCs) as well as activating T lymphocytes. In the current study, the immunologic cytotoxicity promoting effect of LBP was assessed and the underlying mechanism was explored. The impact of LBP on the phenotype, maturation, and immunogenicity of DCs was assessed. The activity of Notch pathway which is involved in the regulation of LBP on DCs was detected...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29615468/intrahepatic-bile-ducts-guide-establishment-of-the-intrahepatic-nerve-network-in-developing-and-regenerating-mouse-liver
#5
Naoki Tanimizu, Norihisa Ichinohe, Toshihiro Mitaka
Epithelial organs consist of multiple tissue structures such as epithelial sheets, blood vessels, and nerves, which are spatially organized to achieve optimal physiological functions. The hepatic nervous system has been implicated in physiological functions and regeneration of the liver. However, the processes of development and reconstruction of the intrahepatic nerve network and its underlying mechanisms remain unknown. Here we demonstrate that class III β-tubulin (TUBB3)+ nerve fibers are not distributed in intrahepatic tissue at embryonic day 17...
April 3, 2018: Development
https://www.readbyqxmd.com/read/29599482/the-notch-inhibitor-cowanin-accelerates-nicastrin-degradation
#6
Midori A Arai, Ryuta Akamine, Anna Tsuchiya, Tatsuro Yoneyama, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi
Aberrant activation of Notch signaling contributes to the pathogenesis of several different types of cancer, and Notch pathway inhibitors may have significant therapeutic potential. Using a unique cell-based assay system, we isolated twelve compounds, including one new natural product from Garcinia speciosa, that inhibit the Notch signaling pathway. HES1 and HES5 are target genes of the Notch cascade, and compound 2, referred to as cowanin, decreased the protein levels of HES1 and HES5 in assay cells. Furthermore, cowanin (2) showed potent cytotoxicity against human leukemic HPB-ALL cells...
March 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29593575/dai-zong-fang-a-traditional-chinese-herbal-formula-ameliorates-insulin-resistance-in-db-db-mice
#7
Lili Zhu, Xiaoyun Zhu, Guibo Sun, Xiangbao Meng, Min Wang, Hanming Cui, Jialong Wang, Yadong Zhai, Ke Yang, Yang Tang, Xiaobo Sun, Ximing Liu
Intricate health problems, such as insulin resistance (IR) and its associated diseases, call for multi-targeted therapies with few side effects. Based on traditional Chinese medicine (TCM), Dai-Zong-Fang (DZF) is an herbal formula mainly composed of Rhizoma Coptidis (Huanglian) and Fructus Aurantii Immaturus (Zhishi), of which berberine and naringin are the main constituents. Though DZF has been clinically used for treatment of IR and metabolic syndrome for decades, its mechanism in vivo remains unknown. In the present study, we observed that both DZF and metformin, the first-line drug for type 2 diabetes, ameliorated insulin resistance with significant improvement of oral glucose tolerance test (OGTT) and homeostasis model assessment of IR (HOMA-IR) level in diabetic C57BL/Ksj-Lepr db -/- ( db/db ) mice...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29578180/effect-of-lenalidomide-on-the-human-gastric-cancer-cell-line-sgc7901-vincristine-notch-signaling
#8
Wanjun Ding, Tao Zeng, Weiping Tao, Wei Ge, Junjian Deng, Hongbo Lei, Yong Xiao, Fei Liao
Aim of Study: To examine the function of lenalidomide (LEN) on the human multidrug resistance (MDR)-type gastric cancer line SGC7901/vincristine (VCR) via regulating Notch signaling. Materials and Methods: Quantitative polymerase chain reaction was used for checking the genes of Notch, DNA methyltransferase (DNMT), RBP-J, Hes1/5, Deltex1, MDR/multidrug resistant protein (MRP); the cell proliferation and cell death were detected by cell counting kit-8 (CCK8) staining, Ki-67 expression, and propidium-iodide staining, and methylated DNA immunoprecipitation assay (MeDIP) was used for checking the 5 mC enrichment, indicating the DNA methylation of the Notch2 gene loci...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29562732/indole-3-carbinol-promotes-goblet-cell-differentiation-regulating-wnt-and-notch-signaling-pathways-ahr-dependently
#9
Joo-Hung Park, Jeong-Min Lee, Eun-Jin Lee, Won-Bhin Hwang, Da-Jeong Kim
Using an in vitro model of intestinal organoids derived from intestinal crypts, we examined effects of indole-3-carbinol (I3C), a phytochemical that has anticancer and aryl hydrocarbon receptor (AhR)-activating abilities and thus is sold as a dietary supplement, on the development of intestinal organoids and investigated the underlying mechanisms. I3C inhibited the in vitro development of mouse intestinal organoids. Addition of α-naphthoflavone, an AhR antagonist or AhR siRNA transfection, suppressed I3C function, suggesting that I3C-mediated interference with organoid development is AhR-dependent...
March 21, 2018: Molecules and Cells
https://www.readbyqxmd.com/read/29557377/hyperhomocysteinemia-induces-injury-in-olfactory-bulb-neurons-by-downregulating-hes1-and-hes5-expression
#10
Jing-Wen Zhang, Bo Pang, Qi Zhao, Yue Chang, Yi-Li Wang, Yi-Deng Jiang, Li Jing
Hyperhomocysteinemia has been shown to be associated with neurodegenerative diseases; however, lesions or histological changes and mechanisms underlying homocysteine-induced injury in olfactory bulb neurons remain unclear. In this study, hyperhomocysteinemia was induced in apolipoprotein E-deficient mice with 1.7% methionine. Pathological changes in the olfactory bulb were observed through hematoxylin-eosin and Pischingert staining. Cell apoptosis in the olfactory bulb was determined through terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) staining...
February 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29556333/upregulation-of-hes1-promotes-cell-proliferation-and-invasion-in-breast-cancer-as-a-prognosis-marker-and-therapy-target-via-the-akt-pathway-and-emt-process
#11
Xiaoying Li, Yu Cao, Mu Li, Feng Jin
HES1 is a transcriptional repressor involved in cell differentiation and proliferation as well as in various cancer developments, but its expression pattern and biological roles in breast cancer have not been examined. In this study, we assessed HES1 expression in breast cancer tissues using immunohistochemistry and Western blot analyses and investigated HES1 function using MTT and Matrigel invasion assays. Significant relationships were observed between HES1 upregulation and advanced TNM stage (p=0.011), node metastasis (p=0...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29533972/high-notch1-mrna-expression-is-associated-with-better-survival-in-hnscc
#12
Markus Wirth, Daniel Jira, Armin Ott, Guido Piontek, Anja Pickhard
The clinical impact of the expression of NOTCH1 signaling components in squamous cell carcinoma of the pharynx and larynx has only been evaluated in subgroups. The aim of this study was therefore to evaluate NOTCH1 expression in head and neck squamous cell cancer (HNSCC) patient tissue and cell lines. We analyzed tissue from 195 HNSCCs and tissue from 30 normal patients for mRNA expression of NOTCH1, NOTCH3, HES1, HEY1, and JAG1 using quantitative real-time PCR. Association of expression results and clinical orpathological factors was examined with multivariate Cox regression...
March 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29532851/microrna-30e-protects-the-heart-against-ischemia-and-reperfusion-injury-through-autophagy-and-the-notch1-hes1-akt-signaling-pathway
#13
Jianjie Zheng, Jing Li, Bo Kou, Qiuyue Yi, Tao Shi
The aim of the present study was to determine the cardioprotective mechanisms by which micro (mi)RNA-30e protects the heart from myocardial ischemia/reperfusion injury (MI/R) and to explore the signaling pathways that may confer protection for the heart and be potential therapeutic targets. It was demonstrated that miRNA‑30e expression was decreased in patients with MI/R. In H9C2 cells, silencing (si)miRNA‑30e significantly inhibited cellular apoptosis, the expression of apoptosis regulator BAX (Bax) and caspase‑3 activity...
March 7, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29523683/small-molecule-screening-yields-a-compound-that-inhibits-the-cancer-associated-transcription-factor-hes1-via-the-phb2-chaperone
#14
Amelie Perron, Yoshihiro Nishikawa, Jun Iwata, Hiromi Shimojo, Junichiro Takaya, Kumiko Kobayashi, Itaru Imayoshi, Naasson Mbambi Mbenza, Mihoko Takenoya, Ryoichiro Kageyama, Yuzo Kodama, Motonari Uesugi
The transcription factor Hes family bHLH transcription factor 1 (Hes1) is a downstream effector of Notch signaling and plays a crucial role in orchestrating developmental processes during the embryonic stage. However, its aberrant signaling in adulthood is linked to the pathogenesis of cancer. In the present study, we report the discovery of small organic molecules (JI051 and JI130) that impair the ability of Hes1 to repress transcription. Hes1 interacts with the transcriptional corepressor transducing-like enhancer of split 1 (TLE1) via an interaction domain comprising two tryptophan residues, prompting us to search a chemical library of 1,800 small molecules enriched for indole-like π-electron-rich pharmacophores for a compound that blocks Hes1-mediated transcriptional repression...
March 9, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29511449/hdac-inhibitors-suppressed-small-cell-lung-cancer-cell-growth-and-enhanced-the-suppressive-effects-of-receptor-targeting-cytotoxins-via-upregulating-somatostatin-receptor-ii
#15
Lichun Sun, Quanyong He, Cheguo Tsai, Jun Lei, Jing Chen, Lily Vienna Makcey, David H Coy
Small cell lung cancer (SCLC) is a malignant human cancer and patients have very limited benefit from traditional anticancer treatments, with a poor five-year survival rate being 10% less. In present study, we observed that Notch signalling activation induced SCLC cell growth suppression via overexpressing Notch active fragments (ICN1, ICN2, ICN3 and ICN4), implying its tumor suppressive role. The histone deacetylase (HDAC) inhibitors also displayed their suppressive effects. Valproic acid (VPA) as a HDAC inhibitor was found to suppress SCLC cell growth and cell cycle arrest at phase G1, and observed to decrease HDAC4 and increase acetylation of histone H4 (AcH4) while activating Notch signalling with an increase of Notch1, Notch target gene HES1 and p21...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29507758/a-personalized-multiomics-approach-identifies-genes-involved-in-cardiac-hypertrophy-and-heart-failure
#16
Marc Santolini, Milagros C Romay, Clara L Yukhtman, Christoph D Rau, Shuxun Ren, Jeffrey J Saucerman, Jessica J Wang, James N Weiss, Yibin Wang, Aldons J Lusis, Alain Karma
A traditional approach to investigate the genetic basis of complex diseases is to identify genes with a global change in expression between diseased and healthy individuals. However, population heterogeneity may undermine the effort to uncover genes with significant but individual contribution to the spectrum of disease phenotypes within a population. Here we investigate individual changes of gene expression when inducing hypertrophy and heart failure in 100 + strains of genetically distinct mice from the Hybrid Mouse Diversity Panel (HMDP)...
2018: NPJ Systems Biology and Applications
https://www.readbyqxmd.com/read/29496446/notch1-regulates-pten-expression-to-exacerbate-renal-tubulointerstitial-fibrosis-in-diabetic-nephropathy-by-inhibiting-autophagy-via-interactions-with-hes1
#17
XingMei Liu, YingYing Zhang, MingJun Shi, YuanYuan Wang, Fan Zhang, Rui Yan, LingLing Liu, Ying Xiao, Bing Guo
Diabetic nephropathy (DN) is a serious clinical microvascular complication of diabetes mellitus. DN is characterized by the accumulation of extracellular matrix, resulting in progressive fibrosis leading to the loss of renal function. Notch1 and phosphatase and tensin homolog deleted on chromosome ten (PTEN) signaling have been associated with fibrosis. Autophagy serves as an essential regulator of tubular cellular homeostasis. However, how these molecules control the balance between fibrosis and autophagy, the main homeostatic mechanism regulating fibrosis, is not well understood...
February 26, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29491143/hairy-and-enhancer-of-split-1-hes1-protects-cells-from-endoplasmic-reticulum-stress-induced-apoptosis-through-repression-of-gadd34
#18
Ji Eun Lee, William Morrison, Julie Hollien
Disruption in endoplasmic reticulum (ER) function, termed ER stress, occurs in many diseases, including neurodegenerative disorders, diabetes, and cancer. Cells respond to ER stress with the unfolded protein response (UPR), which triggers a broad transcriptional program to restore and enhance ER function. Here, we found that ER stress upregulates the mRNA encoding the developmentally regulated transcriptional repressor hairy and enhancer of split 1 ( HES1 ), in a variety cell types. Depletion of HES1 increased cell death in response to ER stress in mouse and human cells, in a manner that was dependent on the pro-apoptotic gene Growth arrest and DNA damage-inducible protein GADD34 (also known as Protein phosphatase 1 regulatory subunit 15A , or MyD116 )...
February 28, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29476947/in-vivo-maternal-and-in-vitro-bpa-exposure-effects-on-hypothalamic-neurogenesis-and-appetite-regulators
#19
Mina Desai, Monica G Ferrini, Guang Han, Juanita K Jellyman, Michael G Ross
In utero exposure to the ubiquitous plasticizer, bisphenol A (BPA) is associated with offspring obesity. As food intake/appetite is one of the critical elements contributing to obesity, we determined the effects of in vivo maternal BPA and in vitro BPA exposure on newborn hypothalamic stem cells which form the arcuate nucleus appetite center. For in vivo studies, female rats received BPA prior to and during pregnancy via drinking water, and newborn offspring primary hypothalamic neuroprogenitor (NPCs) were obtained and cultured...
February 21, 2018: Environmental Research
https://www.readbyqxmd.com/read/29472102/modeling-human-pancreatic-beta-cell-dedifferentiation
#20
Marc Diedisheim, Masaya Oshima, Olivier Albagli, Charlotte Wennberg Huldt, Ingela Ahlstedt, Maryam Clausen, Suraj Menon, Alexander Aivazidis, Anne-Christine Andreasson, William G Haynes, Piero Marchetti, Lorella Marselli, Mathieu Armanet, Fabrice Chimienti, Raphael Scharfmann
OBJECTIVE: Dedifferentiation could explain reduced functional pancreatic β-cell mass in type 2 diabetes (T2D). METHODS: Here we model human β-cell dedifferentiation using growth factor stimulation in the human β-cell line, EndoC-βH1, and human pancreatic islets. RESULTS: Fibroblast growth factor 2 (FGF2) treatment reduced expression of β-cell markers, (INS, MAFB, SLC2A2, SLC30A8, and GCK) and activated ectopic expression of MYC, HES1, SOX9, and NEUROG3...
February 8, 2018: Molecular Metabolism
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