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https://www.readbyqxmd.com/read/29902458/microrna-374b-promotes-the-proliferation-and-differentiation-of-neural-stem-cells-through-targeting-hes1
#1
Xiaoying Wu, Xiaojun Zhao, Xingyu Miao
Accumulating evidence has documented that microRNAs (miRNAs) are critical regulators of neural stem cell (NSC) proliferation and differentiation. MiRNA-374b (miR-374b) has been reported to play an important role in regulating various cellular processes, such as proliferation and differentiation. However, whether miR-374b is involved in NSC proliferation and differentiation remains unclear. In this study, we investigated the potential role of miR-374b in regulating NSC proliferation and differentiation to elucidate the underlying molecular mechanism...
June 11, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29897487/dietary-red-raspberry-reduces-colorectal-inflammation-and-carcinogenic-risk-in-mice-with-dextran-sulfate-sodium-induced-colitis
#2
Shima Bibi, Min Du, Mei-Jun Zhu
Background: Ulcerative colitis causes recurring intestinal mucosal injury and sustained inflammation, increasing the likelihood of colorectal cancer (CRC) development. Dietary red raspberry (RB) is a rich source of phytonutrients known to have anti-inflammatory activity; however, the role of RB on CRC prevention in chronic colitis has not been examined. Objective: This study examined the effects of dietary RB supplementation on inflammation, epithelium repair, and oncogenic signaling in dextran sulfate sodium (DSS)-induced chronic colitis in mice...
April 20, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29880864/author-correction-analysis-of-m%C3%A3-ller-glia-specific-genes-and-their-histone-modification-using-hes1-promoter-driven-egfp-expressing-mouse
#3
Kazuko Ueno, Toshiro Iwagawa, Genki Ochiai, Hideto Koso, Hiromitsu Nakauchi, Masao Nagasaki, Yutaka Suzuki, Sumiko Watanabe
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
June 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29879147/interrogation-of-transcriptomic-changes-associated-with-drug-induced-hepatic-sinusoidal-dilatation-in-colorectal-cancer
#4
Monika A Jarzabek, William R Proctor, Jennifer Vogt, Rupal Desai, Patrick Dicker, Gary Cain, Rajiv Raja, Jens Brodbeck, Dale Stevens, Eric P van der Stok, John W M Martens, Cornelis Verhoef, Priti S Hegde, Annette T Byrne, Jacqueline M Tarrant
Drug-related sinusoidal dilatation (SD) is a common form of hepatotoxicity associated with oxaliplatin-based chemotherapy used prior to resection of colorectal liver metastases (CRLM). Recently, hepatic SD has also been associated with anti-delta like 4 (DLL4) cancer therapies targeting the NOTCH pathway. To investigate the hypothesis that NOTCH signaling plays an important role in drug-induced SD, gene expression changes were examined in livers from anti-DLL4 and oxaliplatin-induced SD in non-human primate (NHP) and patients, respectively...
2018: PloS One
https://www.readbyqxmd.com/read/29874112/notch1-regulates-endothelial-apoptosis-via-erk-pathway-in-chronic-obstructive-pulmonary-disease
#5
Dandan Zong, Jinhua Li, Shan Cai, Shengdong He, Qingqing Liu, Jiehan Jiang, Shanshan Chen, Yingjiao Long, Yan Chen, Ping Chen, Ruoyun Ouyang
Notch signaling is a critical cell fate determinant of proliferation, differentiation, and apoptosis. In this current study we aimed to investigate whether Notch signaling is involved in cigarette smoke (CS) induced endothelial apoptosis in COPD. Surgical specimens were obtained from 10 patients with COPD and 10 control participants. Notch1, 2, 4 were expressed in endothelial cells, whereas, Notch3 was mainly localized in smooth muscle cells. Decreased Notch1, 3, 4 and the target gene Hes1 and Hes2, increased Notch2 and extracellular signal-regulated kinase (ERK)1/2 were found in COPD patients compared with controls, as well as in human pulmonary microvascular endothelial cells (HPMECs) when exposed to CS extract (CSE)...
June 6, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29867921/acetylation-dependent-regulation-of-notch-signaling-in-macrophages-by-sirt1-affects-sepsis-development
#6
Xiaozhi Bai, Ting He, Yang Liu, Julei Zhang, Xiaoqiang Li, Jihong Shi, Kejia Wang, Fu Han, Wei Zhang, Yijie Zhang, Weixia Cai, Dahai Hu
SIRT1 is reported to participate in macrophage differentiation and affect sepsis, and Notch signaling is widely reported to influence inflammation and macrophage activation. However, the specific mechanisms through which SIRT1 regulates sepsis and the relationship between SIRT1 and Notch signaling remain poorly elucidated. In this study, we found that SIRT1 levels were decreased in sepsis both in vitro and in vivo and that SIRT1 regulation of Notch signaling affected inflammation. In lipopolysaccharide (LPS)-induced sepsis, the levels of Notch signaling molecules, including Notch1, Notch2, Hes1, and intracellular domain of Notch (NICD), were increased...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29858025/alterations-of-notch-pathway-in-patients-with-adenoid-cystic-carcinoma-of-the-trachea-and-its-impact-on-survival
#7
Mian Xie, Shenhai Wei, Xiaojun Wu, Xiaoxiang Li, You You, Chaosheng He
INTRODUCTION: Adenoid cystic carcinoma (ACC) of the trachea lacks of well-characterized molecular markers. There is currently no specific treatment for metastatic ACC of the trachea. This study aimed to identify genomic mutations of Notch pathway and investigate the efficacy of NOTCH inhibitor in ACC of the trachea. METHODS: 73 Patients with ACC of the trachea at four institutions from 2008 to 2016 were identified. Analysis of hotspot mutations in cancer-related genes of Notch pathway was performed using next generation sequencing...
July 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29802140/notch-inhibitor-screening-reveals-an-unexpected-hes1-heterodimer
#8
Krizia Rohena-Rivera, Neil A Bhowmick
Notch signaling plays critical roles in cancer progression, motivating efforts to identify inhibitors of this pathway. Perron et al. report a small-molecule screen intended to discover compounds that could interfere with the downstream transcription factor HES1. Target validation of their compounds unexpectedly identified a novel HES1-interacting protein, prohibitin 2. This highlights a new mechanism to block Notch signaling and prompting further exploration of HES1 biology.
May 25, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29785394/notch-signaling-pathway-is-inhibited-in-the-development-of-barrett-s-esophagus-an-in-vivo-and-in-vitro-study
#9
Yun-Cang Wang, Zhi-Qiang Wang, Yong Yuan, Tao Ren, Peng-Zhi Ni, Long-Qi Chen
Objective: To explore the role of Notch signaling in the development of Barrett's esophagus. Methods: Patients with esophagectomy and gastric interposition were recruited as a human model of gastroesophageal reflux disease. The expressions of Notch signaling genes in normal esophagus from surgical specimen and columnar metaplasia in the esophageal remnant after esophagectomy were evaluated by real time quantitative Polymerase Chain Reaction (RT-qPCR) and immunohistochemistry (IHC)...
2018: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29780306/spontaneous-hair-cell-regeneration-is-prevented-by-increased-notch-signaling-in-supporting-cells
#10
Melissa M McGovern, Luyi Zhou, Michelle R Randle, Brandon C Cox
During embryonic development, differentiation of cochlear progenitor cells into hair cells (HCs) or supporting cells (SCs) is partially controlled through Notch signaling. Many studies have shown that inhibition of Notch signaling allows SCs to convert into HCs in both normal and drug damaged neonatal mouse cochleae. This mechanism is also implicated during HC regeneration in non-mammalian vertebrates; however, the mechanism of spontaneous HC regeneration in the neonatal mouse cochlea is less understood. While inhibition of Notch signaling can force SCs to convert into HCs and increase the number of regenerated HCs, it is currently unknown whether this pathway is involved in spontaneous HC regeneration observed in vivo ...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29769415/upregulation-of-microrna-340-promotes-osteosarcoma-cell-apoptosis-while-suppressing-proliferation-migration-and-invasion-by-inactivating-the-ctnnb1-mediated-notch-signaling-pathway
#11
Bao-Long Pan, Ling Wu, Li Pan, Yu-Xi Yang, Hu-Huan Li, Yan-Juan Dai, Zi-Qian He, Ling Tan, You-Guang Huang, Zong-Wu Tong, Jun-Long Liao
Osteosarcoma (OS) is the most common histological form of primary bone cancer. It is most prevalent in teenagers and young adults. This study aims at exploring the regulatory effect of microRNA-340 (miR-340) on OS cell proliferation, invasion, migration and apoptosis via regulating the Notch signaling pathway by targeting CTNNB1. OS tissues belonging to 45 patients and normal femoral head tissues of 45 amputees were selected. Cells were allocated to different groups. In Situ hybridization was performed to determine the positive rate of miR-340 expression while immunohistochemistry was used to determine that of CTNNB1 and B-cell lymphoma 2 (Bcl-2)...
May 16, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29750292/microrna%C3%A2-381-hes1-is-a-potential-therapeutic-target-for-spinal-cord-injury
#12
Wendong Ruan, Guangzhi Ning, Shiqing Feng, Shijie Gao, Yan Hao
The aim of the present study was to investigate whether microRNA‑381 is a potential therapeutic target for spinal cord injury (SCI) and its possible mechanism. Reverse transcription quantitative polymerase chain reaction (qPCR) for mRNA expression was used to analyze the changes of microRNA-381 expression. Cell viability and cell apoptosis were measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and flow cytometry. Caspase‑3 activity was measured using caspase‑3 activity kit, and western blot analysis was used to measure the protein expression of neurogenic locus notch homolog protein 1 (Notch1), notch 1 intracellular domain (NICD) and transcription factor HES-1 (Hes1)...
August 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29727574/reconstitution-of-an-ultradian-oscillator-in-mammalian-cells-by-a-synthetic-biology-approach
#13
Marco Santorelli, Daniela Perna, Akihiro Isomura, Immacolata Garzilli, Francesco Annunziata, Lorena Postiglione, Barbara Tumaini, Ryoichiro Kageyama, Diego di Bernardo
The Notch effector gene Hes1 is an ultradian clock exhibiting cyclic gene expression in several progenitor cells, with a period of a few hours. Because of the complexity of studying Hes1 in the endogenous setting, and the difficulty of imaging these fast oscillations in vivo, the mechanism driving oscillations has never been proven. Here, we applied a "build it to understand it" synthetic biology approach to construct simplified 'hybrid' versions of the Hes1 ultradian oscillator combining synthetic and natural parts...
May 4, 2018: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29717634/notch-signaling-enhances-stemness-by-regulating-metabolic-pathways-through-modifying-p53-nf-%C3%AE%C2%BAb-and-hif-1%C3%AE
#14
Hiroyuki Moriyama, Mariko Moriyama, Toshiyuki Ozawa, Daisuke Tsuruta, Taro Iguchi, Satoshi Tamada, Tatsuya Nakatani, Koichi Nakagawa, Takao Hayakawa
Human adipose-derived stromal cells (hASCs) are attractive for regenerative medicine, but their limited in vitro lifespan limits their therapeutic applicability. Recent data demonstrate that hypoxia may benefit the ex vivo culture of stem cells. Such cells exhibit a high level of glycolytic metabolism under hypoxic conditions. However, the physiological role of glycolytic activation and its underlying regulatory mechanism are incompletely understood. We have shown that when activated under conditions of 5% O<sub>2</sub>, Notch signaling dramatically increases the rate of glycolysis, improves proliferation efficiency, prevents senescence, and maintains the multipotency of hASCs...
May 2, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29703138/transcriptional-profiling-of-human-bronchial-epithelial-cell-beas-2b-exposed-to-diesel-and-biomass-ultrafine-particles
#15
Andrea Grilli, Rossella Bengalli, Eleonora Longhin, Laura Capasso, Maria Carla Proverbio, Mattia Forcato, Silvio Bicciato, Maurizio Gualtieri, Cristina Battaglia, Marina Camatini
BACKGROUND: Emissions from diesel vehicles and biomass burning are the principal sources of primary ultrafine particles (UFP). The exposure to UFP has been associated to cardiovascular and pulmonary diseases, including lung cancer. Although many aspects of the toxicology of ambient particulate matter (PM) have been unraveled, the molecular mechanisms activated in human cells by the exposure to UFP are still poorly understood. Here, we present an RNA-seq time-course experiment (five time point after single dose exposure) used to investigate the differential and temporal changes induced in the gene expression of human bronchial epithelial cells (BEAS-2B) by the exposure to UFP generated from diesel and biomass combustion...
April 27, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29702280/crosstalk-between-toll-like-receptor-3-and-notch-signaling-contributes-to-cd14-monocytes-activity-in-enterovirus-71-infected-hand-foot-and-mouth-disease
#16
Jie Hao, Peiling Li, Yunjiao Tian, Yanhua Wang, Suqing Li, Lina Wang, Shujun Li
Interaction between Toll-like receptor (TLR) and Notch signaling contributes to inflammatory response in nephropathy and fungicidal infection, however, the role of this crosstalk remains not fully elucidated in enterovirus 71 (EV71)-induced hand, foot, and mouth disease (HFMD). The aim of this study was to investigate the crosstalk between TLR and Notch in inflammatory regulation in EV71 infection. Thirty-seven EV-71-indcued HFMD (16 mild and 21 severe cases) and eleven normal control (NC) were enrolled. CD14+ monocytes were purified, and were stimulated with either TLR3/4 agonists [poly(I: C) or LPS] or Notch signaling inhibitor...
April 24, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29693393/the-notch-inhibitors-isolated-from-nerium-indicum
#17
Midori A Arai, Ryuta Akamine, Narumi Hayashi, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi
Notch signaling plays a crucial role in differentiation and cell maintenance, but once aberrantly activated, it contributes to cancer progression. Notch inhibitors were isolated from plant extracts and tested using an originally constructed cell-based assay system. We isolated eight compounds from Nerium indicum that showed inhibition of the Notch signaling pathway. HES1 and HES5 are target genes of the Notch signaling pathway, and oleandrin (1) decreased the protein levels of HES1 and HES5 in assay cells. Oleandrin (1) showed potent cytotoxicity against HPB-ALL cells and decreased HES1 and the Notch intracellular domain in these cells...
May 25, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29680697/regeneration-of-cochlear-hair-cells-and-hearing-recovery-through-hes1-modulation-with-sirna-nanoparticles-in-adult-guinea-pigs
#18
Xiaoping Du, Qunfeng Cai, Matthew B West, Ibrahima Youm, Xiangping Huang, Wei Li, Weihua Cheng, Don Nakmali, Donald L Ewert, Richard D Kopke
Deafness is commonly caused by the irreversible loss of mammalian cochlear hair cells (HCs) due to noise trauma, toxins, or infections. We previously demonstrated that small interfering RNAs (siRNAs) directed against the Notch pathway gene, hairy and enhancer of split 1 (Hes1), encapsulated within biocompatible poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) could regenerate HCs within ototoxin-ablated murine organotypic cultures. In the present study, we delivered this sustained-release formulation of Hes1 siRNA (siHes1) into the cochleae of noise-injured adult guinea pigs...
May 2, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29672732/novel-genes-ancient-genes-and-gene-co-option-contributed-to-the-genetic-basis-of-the-radula-a-molluscan-innovation
#19
Leon Hilgers, Stefanie Hartmann, Michael Hofreiter, Thomas von Rintelen
The radula is the central foraging organ and apomorphy of the Mollusca. However, in contrast to other innovations, including the mollusk shell, genetic underpinnings of radula formation remain virtually unknown. Here, we present the first radula formative tissue transcriptome using the viviparous freshwater snail Tylomelania sarasinorum and compare it to foot tissue and the shell-building mantle of the same species. We combine differential expression, functional enrichment, and phylostratigraphic analyses to identify both specific and shared genetic underpinnings of the three tissues as well as their dominant functions and evolutionary origins...
July 1, 2018: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29665790/the-oncogenic-effects-of-hes1-on-salivary-adenoid-cystic-carcinoma-cell-growth-and-metastasis
#20
Xiao-Yu Huang, Rui-Huan Gan, Jian Xie, Lin She, Yong Zhao, Lin-Can Ding, Bo-Hua Su, Da-Li Zheng, You-Guang Lu
BACKGROUND: Our previous study demonstrated a close relationship between NOTCH signaling pathway and salivary adenoid cystic carcinoma (SACC). HES1 is a well-known target gene of NOTCH signaling pathway. The purpose of the present study was to further explore the molecular mechanism of HES1 in SACC. METHODS: Comparative transcriptome analyses by RNA-Sequencing (RNA-Seq) were employed to reveal NOTCH1 downstream gene in SACC cells. Immunohistochemical staining was used to detect the expression of HES1 in clinical samples...
April 17, 2018: BMC Cancer
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