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adrenal incidentaloma

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https://www.readbyqxmd.com/read/29643654/role-of-endoscopic-ultrasound-guided-fine-needle-aspiration-in-adrenal-lesions-analysis-of-32-patients
#1
Rakesh K Gupta, Kaushik Majumdar, Ravindra K Saran, Siddharth Srivastava, Puja Sakhuja, Vineeta V Batra
Objective: Endoscopic ultrasound-guided fine-needle aspiration cytology (EUS-FNAC) is a precise and safe technique that provides both radiological and pathological diagnosis with a better diagnostic yield and minimal adverse events. EUS-FNAC led to the remarkable increase in the detection rate of incidentaloma found during radiologic staging or follow-up in various malignancy or unrelated conditions. Aims: We did this preliminary study with an aim to evaluate the role of EUS-FNA in diagnosing and classifying adrenal lesions, clinical impact, and compare the outcome with the previously published literature...
April 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29616752/adrenal-hemorrhage-a-single-center-experience-and-literature-review
#2
Izabela M Karwacka, Łukasz Obołończyk, Krzysztof Sworczak
BACKGROUND: Adrenal hemorrhage (AH) is a rare condition that can lead to acute adrenal insufficiency and may be fatal. The risk factors of AH include focal adrenal lesion, abdominal trauma and anticoagulation therapy. The clinical manifestation of AH varies widely; the symptoms may be related to adrenal insufficiency or may reflect multiple organ failure. However, in many cases, the course of AH is asymptomatic. OBJECTIVES: The study is a retrospective analysis of 23 cases of AH, whose aim is to discuss the etiology and the management of selected patients, as well as a literature review...
March 27, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29608696/serum-cortisol-levels-via-radioimmunoassay-vs-liquid-chromatography-mass-spectrophotometry-in-healthy-control-subjects-and-patients-with-adrenal-incidentalomas
#3
Martha K P Huayllas, Brian C Netzel, Ravinder J Singh, Claudio E Kater
Background: Adrenal incidentalomas (AIs) are present in 4% of adults. As many as 30% may secrete cortisol autonomously in the absence of specific signs of overt hypercortisolism, in a phenomenon called subclinical hypercortisolism (SH). Diagnosis of SH is established by serum cortisol resistance to dexamethasone suppression. Methods: We compared serum cortisol concentrations, as determined by radioimmunoassay (RIA) and liquid chromatography/tandem mass spectronomy (LC/MS-MS), in 73 patients with AI group (52 with unilateral AI) and 34 control subjects in 3 scenarios: basal; after 1-mg dexamethasone suppression; and after 0...
March 28, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/29606280/cardiovascular-mortality-in-patients-with-subclinical-cushing
#4
Valentina Morelli, Maura Arosio, Iacopo Chiodini
Patients with adrenal incidentaloma (AI) and subclinical hypercortisolism (SH) show a high prevalence of cardiovascular risk factors and an increased prevalence and incidence of cardiovascular events. Furthermore, some recent data suggest that in these patients, the cardiovascular mortality is also increased. Unfortunately, to date, the diagnosis of SH is still a matter of debate, and, therefore, it is still not possible to address the treatment of choice (i.e. surgical or conservative approach) in many AI patients...
March 29, 2018: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29561525/adrenal-hemangioma-definite-diagnosis-on-ct-mri-and-fdg-pet-in-a-patient-with-primary-lung-cancer
#5
Benjamin Wilson, Allison Becker, Thomas Estes, Jayanth Keshavamurthy, Darko Pucar
Distinguishing adrenal incidentalomas (5% of all abdominal CT scans) from metastasis is a frequent diagnostic challenge in primary malignancies with a propensity for adrenal spread, such as lung cancer. Adrenal myelolipoma and adenoma can be definitively characterized as benign by demonstrating gross and microscopic fat, respectively, on CT and MRI and an absence of abnormal uptake on PET. Unfortunately, adrenal sampling is frequently necessary in indeterminate cases for adequate staging of extra-adrenal primary malignancy...
March 20, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29534610/annals-express-development-of-a-rapid-lc-ms-ms-method-for-the-quantitation-of-serum-dexamethasone-and-its-clinical-verification
#6
James M Hawley, Laura J Owen, Miguel De Bono, John Newell-Price, Brian G Keevil
BACKGROUND: Measurement of serum dexamethasone during the overnight dexamethasone-suppression test (ONDST) has been recommended to reduce false positive results when investigating Cushing's syndrome or increasingly commonly found adrenal incidentalomas. Despite this, there remains a paucity of well-validated dexamethasone methods currently available. Here, we describe the development of a rapid and sensitive LC-MS/MS serum dexamethasone assay and validate its utility in a cohort of postmenopausal females...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29510982/cardiovascular-features-of-possible-autonomous-cortisol-secretion-in-patients-with-adrenal-incidentalomas
#7
Emilia Sbardella, Marianna Minnetti, Denise D'Aluisio, Laura Rizza, Maria Rosaria Di Giorgio, Fabio Vinci, Riccardo Pofi, Elisa Giannetta, Mary Anna Venneri, Annarita Vestri, Sergio Morelli, Andrea Lenzi, Andrea M Isidori
BACKGROUND: Low-grade incomplete post-dexamethasone cortisol suppression in patients with adrenal incidentalomas -recently defined as possible autonomous cortisol secretion (pACS)- has been associated with increased cardiovascular events and mortality. However, prospective studies documenting cardiac abnormalities in these patients are lacking. SUBJECTS AND METHODS: Between July 2016 and September 2017, 71 consecutive patients with adrenal lesions were prospectively screened for hypercortisolism by dexamethasone suppression test (NCT02611258)...
March 6, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29498083/chemical-shift-magnetic-resonance-imaging-could-predict-subclinical-cortisol-production-from-an-incidentally-discovered-adrenal-mass
#8
Serkan Yener, Mustafa Secil, Omer Demir, Basak Ozgen, Kutsal Yorukoglu
CONTEXT: To investigate whether any association between chemical shift magnetic resonance (MRI) findings, cortisol secretion and pathological findings exist that could predict subclinical hypercortisolism (SCH) in patients with adrenal incidentalomas (AI). DESIGN: Retrospective, cross sectional study in a tertiary centre. PATIENTS: Sixty-eight subjects with AIs and 13 patients with Cushing's syndrome (CS). Patients with AIs were categorized according to cortisol levels post 1mg dexamethasone (post-DST)...
March 1, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29495350/the-role-of-insulin-resistance-hyperinsulinism-on-the-rising-trend-of-thyroid-and-adrenal-nodular-disease-in-the-current-environment
#9
REVIEW
Agathocles Tsatsoulis
Thyroid follicular cells, as well as adrenocortical cells, are endowed by an intrinsic heterogeneity regarding their growth potential, in response to various stimuli. This heterogeneity appears to constitute the underlying cause for the focal cell hyperplasia and eventually the formation of thyroid and adrenal nodules, under the influence of growth stimulatory factors. Among the main stimulatory factors are the pituitary tropic hormones, thyroid-stimulating hormone (TSH) or thyrotropin and adrenocorticotropic hormone (ACTH), which regulate the growth and function of their respective target cells, and the insulin/insulin-like growth factor system, that, through its mitogenic effects, can stimulate the proliferation of these cells...
February 26, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29467231/diagnostic-accuracy-of-computed-tomography-to-identify-adenomas-and-benign-tumors-amongst-adrenal-incidentalomas-in-an-endocrinological-population
#10
Marie Marty, Delphine Gaye, Paul Perez, Claire Auder, Marie-Laure Nunes, Amandine Ferriere, Magalie Haissaguerre, Antoine Tabarin
CONTEXT: the recent recommendations of the European endocrine society states that the performance of computed tomography (CT) to characterize true adrenal incidentalomas (AIs) remains debatable. OBJECTIVE: to determine relevant thresholds for usual CT parameters for the diagnosis of benign tumors using robust reference standard amongst a large series of "true" AIs recruited in an endocrinological setting. DESIGN: retrospective study of 253 AIs in 233 consecutive patients explored in a single university hospital: 183 adenomas, 33 pheochromocytomas, 23 adrenocortical carcinomas, 5 other malignant tumors and 9 other benign tumors...
February 21, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29467230/unenhanced-ct-imaging-is-highly-sensitive-to-exclude-pheochromocytoma-a-multicenter-study
#11
Edward Buitenwerf, Tijmen Korteweg, Anneke Visser, Charlotte Msc Haag, Richard A Feelders, Henri J Timmers, Letizia Canu, H R Haak, Peter H Bisschop, E Marelise W Eekhoff, Eleonora Pm van der Kleij-Corssmit, Nanda C Krak, Elise Rasenberg, Janneke van den Bergh, Jaap Stoker, Marcel Jw Greuter, Robin P F Dullaart, Thera P Links, Michiel N Kerstens
BACKGROUND: A substantial proportion of all pheochromocytomas is currently detected during the evaluation of an adrenal incidentaloma. Recently it has been suggested that biochemical testing to rule out pheochromocytoma is unnecessary in case of an adrenal incidentaloma with an unenhanced attenuation value ≤10 Hounsfield Units (HU) at computed tomography (CT). OBJECTIVES: We aimed to determine the sensitivity of the 10 HU threshold value to exclude a pheochromocytoma...
February 21, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29444898/significant-prevalence-of-nr3c1-mutations-in-incidentally-discovered-bilateral-adrenal-hyperplasia-results-of-the-french-muta-gr-study
#12
Geraldine Vitellius, Séverine Trabado, Christine Hoeffel-Fornes, Jerome Bouligand, Antoine Bennet, Frédéric Castinetti, Bénédicte Decoudier, Anne Guiochon-Mantel, Marc Lombes, Brigitte Delemer
Recently discovered mutations of NR3C1 gene, encoding for the Glucocorticoid Receptor (GR), in patients with glucocorticoid resistance and bilateral adrenal incidentalomas prompted us to investigate whether GR mutations might be associated with adrenal hyperplasia. OBJECTIVE: The multicenter French Clinical Research Program (Muta-GR) was set up to determine the prevalence of GR mutations and polymorphisms in patients harboring bilateral adrenal incidentalomas associated with hypertension and/or biological hypercortisolism without clinical Cushing's signs...
February 14, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29442478/a-clinical-audit-diagnostic-and-epidemiological-evaluation-of-the-adrenal-incidentaloma-ai
#13
Vincenzo Nuzzo, Tiziana Attardo, Giuseppe Augello, Davide Brancato, Salvatore Camerlingo, Clelia Canale, Federica Coretti, Alessandro Franco, Francesco Giacometti, Maurizio Gambacorta, Massimo Loreno, Ada Maffettone, Vincenzo Provenzano, Alfonso Zuccoli
Audit is a clinical instrument of government characterized by a whole process of evaluation inter pares to improve medical behaviors in the clinical practice. Different endocrinopathies are underestimated in the clinical and diagnostics practice but they can be a real problem in patients admitted in the departments of Internal Medicine. The Adrenal Incidentaloma (AI) is an accidental discovery with an incidence equal to 4% in radiologic studies but it's rarely considereted in the internal disorders. In the departments of Internal Medicine are hospitalized each year approximately 1...
February 13, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29348428/evaluation-of-quantitative-parameters-for-distinguishing-pheochromocytoma-from-other-adrenal-tumors
#14
Youichi Ohno, Masakatsu Sone, Daisuke Taura, Toshinari Yamasaki, Katsutoshi Kojima, Kyoko Honda-Kohmo, Yorihide Fukuda, Koji Matsuo, Toshihito Fujii, Akihiro Yasoda, Osamu Ogawa, Nobuya Inagaki
Adrenal tumors are increasingly found incidentally during imaging examinations. It is important to distinguish pheochromocytomas from other adrenal tumors because of the risk of hypertensive crisis. Although catecholamines and their metabolites are generally used to diagnose pheochromocytoma, false-positive test results are common. An effective screening method to distinguish pheochromocytoma from adrenal incidentalomas is needed. We analyzed 297 consecutive patients with adrenal incidentalomas. Our findings included 162 non-functioning tumors, 47 aldosterone-producing adenomas, 26 metastases, 22 cases of subclinical Cushing's syndrome, 21 pheochromocytomas, 12 cases of Cushing's syndrome, and 7 adrenocortical cancers...
March 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29288564/luteinizing-hormone-and-insulin-resistance-in-menopausal-patients-with-adrenal-incidentalomas-the-cause-effect-relationship
#15
Ljiljana V Marina, Miomira Ivović, Milina Tančić-Gajić, Zorana Arizanović, Dragana Raković, Jelena Milin-Lazović, Aleksandra Kendereški, Dragan Micić, Svetlana Vujović
OBJECTIVE: A high prevalence of insulin resistance (IR) has proven to manifest in patients with adrenal incidentalomas (AI). It has been demonstrated that an increase in IR is related to the size of tumourous masses; additionally, luteinizing hormone (LH)-dependent adrenal pathologies are well documented in patients with LH-responsive adrenal tumours occurring under conditions of physiologically elevated LH. We hypothesized that an association between LH and insulin might play a role in adrenal tumourigenesis and steroidogenesis...
April 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29276876/a-pheochromocytoma-case-diagnosed-as-adrenal-incidentaloma
#16
Doğuş Vurallı, Nurgün Kandemir, Graeme Clark, Diclehan Orhan, Ayfer Alikaşifoğlu, Nazlı Gönç, Saniye Ekinci, Alev Özön
Vurallı D, Kandemir N, Clark G, Orhan D, Alikaşifoğlu A, Gönç N, Ekinci S, Özön A. A pheochromocytoma case diagnosed as adrenal incidentaloma. Turk J Pediatr 2017; 59: 200-206. There are two problems that needs to be addressed in cases of an adrenal incidentaloma. The first is to decide whether the adrenal mass is benign or malignant, and the second is to determine whether the mass is hormonally active or not. A 17-year-old male was admitted with the complaint of progressive weight gain. Abdominal ultrasonography was performed for elevation in transaminases which revealed a hypoechoic mass located in the left adrenal gland...
2017: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/29275606/-diagnostic-value-of-urinary-free-cortisol-in-the-subclinical-cushing-s-syndrome-in-patients-with-adrenal-incidentaloma
#17
L L Li, L Zhao, J T Dou, G Q Yang, W J Gu, Z H Lü, J M Ba, Y M Mu
Objective: To evaluate the efficacy of 24 h urinary free cortisol (24 h UFC) in the diagnosis of subclinical Cushing's syndrome (SCS), and explore the best diagnostic cut-off value. Methods: The clinical data of patients with adrenal incidentaloma in Chinese PLA General Hospital between January 2008 and December 2016 was retrospectively reviewed and analyzed. All SCS patients were diagnosed based on the current Cushing's syndrome (CS) guidelines and confirmed by histopathology and then treated as study group, and additional patients with non-functional adrenal adenoma (NFA) were enrolled as control group...
December 12, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29241951/european-recommendations-for-the-management-of-adrenal-incidentalomas-a-debate-on-patients-follow-up
#18
LETTER
Stéphanie Espiard, Kanza Benomar, Camille Loyer, Claire Vahé, Marie-Christine Vantyghem
No abstract text is available yet for this article.
February 2018: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29223281/human-studies-on-hypothalamo-pituitary-adrenal-hpa-axis
#19
REVIEW
Kamani Liyanarachchi, Richard Ross, Miguel Debono
The daily rhythm of the hypothalamo-pituitary-adrenal (HPA) axis is regulated by the central clock in the suprachiasmatic nucleus. Cortisol, a glucocorticoid, acts as a secondary messenger between the central clock and the peripheral tissues. Changes in clock time, as seen in shift workers, alters the HPA axis and results in metabolic disturbances associated with ill health. Depression, anorexia nervosa and obstructive sleep apnoea, are associated with cortisol rhythm phase shifts and increased cortisol exposure...
October 2017: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29217652/initial-clinical-presentation-and-spectrum-of-pheochromocytoma-a-study-of-94-cases-from-a-single-center
#20
Henrik Falhammar, Magnus Kjellman, Jan Calissendorff
BACKGROUND: With the increasing access to imaging more pheochromocytomas are diagnosed in the workup of adrenal incidentalomas. This may have changed the occurrence of the classic presentation with hypertension and the classic triad (headaches, sweating and palpitation). METHODS: We reviewed 94 consecutive cases of pheochromocytomas. Two cases of ectopic ACTH-syndrome were subsequently excluded. RESULTS: Of the 92 cases included 64% had presented as an incidentaloma, 32% as a suspected pheochromocytoma and 4% had been screened because of previously diagnosed MEN2A...
January 2018: Endocrine Connections
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