Nanami Ohyama, Ayako Furugen, Riko Sawada, Ryoichi Aoyagi, Ayako Nishimura, Takeshi Umazume, Katsuya Narumi, Masaki Kobayashi
The placenta is a critical organ for fetal development and a healthy pregnancy, and has multifaceted functions (e.g., substance exchange and hormone secretion). Syncytialization of trophoblasts is important for maintaining placental functions. Epilepsy is one of the most common neurological conditions worldwide. Therefore, this study aimed to reveal the influence of antiepileptic drugs, including valproic acid (VPA), carbamazepine, lamotrigine, gabapentin, levetiracetam, topiramate, lacosamide, and clobazam, at clinically relevant concentrations on syncytialization using in vitro models of trophoblasts...
June 27, 2023: Toxicology and Applied Pharmacology