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Psychosis and sleep

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https://www.readbyqxmd.com/read/28239920/neuropsychiatric-symptoms-in-south-east-asian-patients-with-mild-cognitive-impairment-and-dementia-prevalence-subtypes-and-risk-factors
#1
Chathuri Yatawara, Shaun Hiu, Laura Tan, Nagaendran Kandiah
BACKGROUND: The subtypes and risk factors of neuropsychiatric symptoms remain largely unexplored in South-East Asian populations. OBJECTIVE: We investigated the prevalence, subtypes, and risk factors, namely, demographic, medical morbidity, and cognitive impairment associated with neuropsychiatric symptoms in a South-East Asian cohort of patients with mild cognitive impairment (MCI) and dementia. METHODS: A clinical cohort of 38 MCI and 198 mild-moderate dementia patients were assessed using the Neuropsychiatric Inventory-Questionnaire...
February 27, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28169087/adolescents-at-clinical-high-risk-for-psychosis-circadian-rhythm-disturbances-predict-worsened-prognosis-at-1-year-follow-up
#2
Jessica R Lunsford-Avery, Bruno da Silva Brandão Gonçalves, Elisa Brietzke, Rodrigo A Bressan, Ary Gadelha, Randy P Auerbach, Vijay A Mittal
BACKGROUND: Individuals with psychotic disorders experience disruptions to both the sleep and circadian components of the sleep/wake cycle. Recent evidence has supported a role of sleep disturbances in emerging psychosis. However, less is known about how circadian rhythm disruptions may relate to psychosis symptoms and prognosis for adolescents with clinical high-risk (CHR) syndromes. The present study examines circadian rest/activity rhythms in CHR and healthy control (HC) youth to clarify the relationships among circadian rhythm disturbance, psychosis symptoms, psychosocial functioning, and the longitudinal course of illness...
February 4, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28145912/possible-opioid-shopping-and-its-correlates
#3
Alexander M Walker, Lisa B Weatherby, M Soledad Cepeda, Daniel Bradford, Yingli Yuan
BACKGROUND: We created an operational definition of possible opioid shopping in US commercial health insurance data and examined its correlates. METHODS: The population consisted of 264,204 treatment courses in persons with a fill for an opioid or diuretic prescription in 2012 and a second within 18 months. We examined counts of prescribers and pharmacies and the numbers of fills and overlaps for ability to discriminate courses of opioids from diuretics, which were a negative control...
January 31, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28141710/the-curse-of-the-dolphins-cognitive-decline-and-psychosis
#4
Randall Phelps, Anne Tsai, Arlene Hagen, Joseph Pinter, Raegan Smith, Martin T Stein
Isela is an 11-year-old Mexican-American girl with mild intellectual disability. During a vacation with her family, she went swimming with dolphins. A few days later, Isela awoke at night with laughing spells; during the day, she was pacing, aggressive, and had a decline in self-care and communication skills. Her parents attributed the symptoms to the dolphins. She was evaluated by a pediatric neurologist. The sleep-deprived electroencephalogram, brain magnetic resonance imaging, lumbar puncture, and thyroid function tests were normal...
February 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28126579/sleep-disturbances-in-individuals-at-clinical-high-risk-for-psychosis
#5
Sarah-Lucy Poe, Gary Brucato, Nicolina Bruno, Leigh Y Arndt, Shelly Ben-David, Kelly E Gill, Tiziano Colibazzi, Joshua T Kantrowitz, Cheryl M Corcoran, Ragy R Girgis
There has been recent interest in understanding the role that sleep disturbance plays in patients at Clinical High Risk for psychosis (CHR). We assessed sleep disturbance in 194 CHR patients and 66 healthy control subjects and their relationship to symptoms (positive, negative and general functioning). Patients experienced significantly more sleep disturbance than healthy control subjects and their sleep disturbance was related to greater positive and negative symptoms and worse overall functioning. Targeting sleep disturbance in CHR individuals may provide alternative means of treating the CHR syndrome...
March 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28102229/the-neurosteroidogenic-enzyme-5%C3%AE-reductase-mediates-psychotic-like-complications-of-sleep-deprivation
#6
Roberto Frau, Valentina Bini, Alessio Soggiu, Simona Scheggi, Alessandra Pardu, Silvia Fanni, Paola Roncada, Monica Puligheddu, Francesco Marrosu, Donatella Caruso, Paola Devoto, Marco Bortolato
Acute sleep deprivation (SD) can trigger or exacerbate psychosis- and mania-related symptoms; the neurobiological basis of these complications, however, remains elusive. Given the extensive involvement of neuroactive steroids in psychopathology, we hypothesized that the behavioral complications of SD may be contributed by 5α-reductase (5αR), the rate-limiting enzyme in the conversion of progesterone into the neurosteroid allopregnanolone. We first tested whether rats exposed to SD may exhibit brain-regional alterations in 5αR isoenzymes and neuroactive steroid levels; then, we assessed whether the behavioral and neuroendocrine alterations induced by SD may be differentially modulated by the administration of the 5αR inhibitor finasteride, as well as progesterone and allopregnanolone...
January 19, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28089250/pathology-of-behavior-in-pd-what-is-known-and-what-is-not
#7
REVIEW
Kaylena A Ehgoetz Martens, Simon J G Lewis
Abnormal behavior in Parkinson's disease (PD) stems from a complex orchestration of impaired neural networks that result from PD-related neurodegeneration across multiple levels. Typically, cellular and tissue abnormalities generate neurochemical changes and disrupt specific regions of the brain, in turn creating impaired neural circuits and dysfunctional global networks. The objective of this chapter is to provide an overview of the array of pathological changes that have been linked to different behavioral symptoms of PD such as depression, anxiety, apathy, fatigue, impulse control disorders, psychosis, sleep disorders and dementia...
March 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28079675/recent-advances-in-the-management-of-neuropsychiatric-symptoms-in-dementia
#8
Orestes V Forlenza, Júlia Cunha Loureiro, Marcos Vasconcelos Pais, Florindo Stella
PURPOSE OF REVIEW: The present article addresses intriguing questions related to the clinical intervention in distinct neuropsychiatric syndromes of patients with dementia. RECENT FINDINGS: We reviewed 154 articles published between 2015 and 2016 targeting psychopharmacological and nonpharmacological interventions, and safety-tolerability concerns. We selected 115 articles addressing the purpose of this study. Of these, 33 were chosen because they were dedicated to subtopics: agitation (42), depression (33), apathy (18), sleep disorders/anxiety (8), and psychosis (4)...
March 2017: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/27988426/the-association-between-sleep-dysfunction-and-psychosis-like-experiences-among-college-students
#9
Nicole D Andorko, Vijay Mittal, Elizabeth Thompson, Danielle Denenny, Gregory Epstein, Caroline Demro, Camille Wilson, Shuyan Sun, Elizabeth A Klingaman, Jordan DeVylder, Hans Oh, Teodor T Postolache, Gloria M Reeves, Jason Schiffman
Sleep problems are prominent and pervasive clinical issues experienced by many people with psychotic disorders, often causing distress and functional impairment. Sleep problems are also related to psychosis-like experiences (PLE; non-diagnosable phenomenon such as transient perceptual disturbances, unusual thoughts, periodic suspiciousness) in epidemiological studies. Prior studies in this field have used brief measures that precluded the ability to test (1) whether risk for psychosis-like experiences are related to specific sub-types of sleep disturbance, and (2) whether sleep disturbance is specifically related to clinically significant (i...
February 2017: Psychiatry Research
https://www.readbyqxmd.com/read/27969065/cross-cultural-variations-in-psychiatrists-perception-of-mental-illness-a-tool-for-teaching-culture-in-psychiatry
#10
COMPARATIVE STUDY
Jhilam Biswas, B N Gangadhar, Matcheri Keshavan
A frequent debate in psychiatry is to what extent major psychiatric diagnoses are universal versus unique across cultures. We sought to identify cultural variations between psychiatrists' diagnostic practices of mental illness in Boston Massachusetts and Bangalore, India. We surveyed psychiatrists to identify differences in how frequently symptoms appear in major mental illness in two culturally and geographically different cities. Indian psychiatrists found somatic symptoms like pain, sleep and appetite to be significantly more important in depression and violent and aggressive behavior to be significantly more common in mania than did American psychiatrists...
October 2016: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/27967238/a-refill-for-the-brain-mineralocorticoid-receptor-the-benefit-of-cortisol-add-on-to-dexamethasone-therapy
#11
Onno C Meijer, E Ronald de Kloet
Some serious medical conditions require life-saving treatment with high doses of synthetic glucocorticoids such as dexamethasone. A substantial number of patients subjected to this treatment develops psychosis, mood disturbance or sleep problems. A recent clinical trial demonstrated that dexamethasone therapy of young patients suffering from acute lymphoblastic leukemia (ALL) caused in about 30% of these patients severe adverse psychological effects and sleep disturbances. These side effects were ameliorated by co-administration of a low dose of the naturally occurring glucocorticoid hormone cortisol...
December 14, 2016: Endocrinology
https://www.readbyqxmd.com/read/27911311/risk-factors-and-pathological-substrates-associated-with-agitation-aggression-in-alzheimer-s-disease-a-preliminary-study-using-nacc-data
#12
Simrin Sennik, Tom A Schweizer, Corinne E Fischer, David G Munoz
BACKGROUND: Neuropsychiatric symptoms are common manifestations of Alzheimer's disease (AD). A number of studies have targeted psychosis, i.e., hallucinations and delusions in AD, but few have assessed agitation/aggression in AD. OBJECTIVE: To investigate the risk factors and pathological substrates associated with presence [A(+)] and absence [A(-)] of agitation/aggression (A) in autopsy-confirmed AD. METHODS: Data was collected from the UDS data as of 2015 on the NACC database...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27824625/intolerance-of-dolutegravir-containing-combination-antiretroviral-therapy-regimens-in-real-life-clinical-practice
#13
Mark G J de Boer, Guido E L van den Berk, Natasja van Holten, Josephine E Oryszcyn, Willemien Dorama, Daoud Ait Moha, Kees Brinkman
OBJECTIVE: Dolutegravir (DGV) is one of the preferred antiretroviral agents in first-line combination antiretroviral therapy (cART). Though considered to be a well tolerated drug, we aimed to determine the actual rate, timing and detailed motivation of stopping DGV in a real-life clinical setting. DESIGN: A cohort study including all patients who started DGV in two HIV treatment centers in The Netherlands. METHODS: All cART-naïve and cART-experienced patients who had started DGV were identified from the institutional HIV databases...
November 28, 2016: AIDS
https://www.readbyqxmd.com/read/27817827/do-depressive-symptoms-predict-paranoia-or-vice-versa
#14
Steffen Moritz, Anja S Göritz, Benjamin McLean, Stefan Westermann, Jeannette Brodbeck
BACKGROUND AND OBJECTIVES: Affective versus nonaffective psychoses are today no longer regarded as mutually exclusive disorders. Theorists have recently highlighted the role of affective symptoms in the formation of paranoid beliefs, particularly negative beliefs about the self, interpersonal sensitivity, sleep disturbances, and worrying, which exist along a continuum in the general population. For the present study, we tested the bidirectional causal relationships between paranoia and affect...
October 18, 2016: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/27796261/the-epidemiology-of-back-pain-and-its-relationship-with-depression-psychosis-anxiety-sleep-disturbances-and-stress-sensitivity-data-from-43-low-and-middle-income-countries
#15
Brendon Stubbs, Ai Koyanagi, Trevor Thompson, Nicola Veronese, Andre F Carvalho, Marco Solomi, James Mugisha, Patricia Schofield, Theodore Cosco, Nicky Wilson, Davy Vancampfort
BACKGROUND: Back pain (BP) is a leading cause of global disability. However, population-based studies investigating its impact on mental health outcomes are lacking, particularly among low- and middle-income countries (LMICs). Thus, the primary aims of this study were to: (1) determine the epidemiology of BP in 43 LMICs; (2) explore the relationship between BP and mental health (depression spectrum, psychosis spectrum, anxiety, sleep disturbances and stress). METHODS: Data on 190,593 community-dwelling adults aged ≥18 years from the World Health Survey (WHS) 2002-2004 were analyzed...
November 2016: General Hospital Psychiatry
https://www.readbyqxmd.com/read/27785919/pharmacotherapies-for-parkinson-s-disease-symptoms-related-to-cholinergic-degeneration
#16
REVIEW
Santiago Perez-Lloret, María Cecilia Peralta, Francisco J Barrantes
Dopamine depletion is one of the most important features of Parkinson's Disease (PD). However, insufficient response to dopaminergic replacement therapy suggests the involvement of other neurotransmitter systems in the pathophysiology of PD. Cholinergic degeneration contributes to gait impairments, cognitive impairment, psychosis, and REM-sleep disturbances, among other symptoms. Areas covered: In this review, we explore the idea that enhancing cholinergic tone by pharmacological or neurosurgical procedures could be a first-line therapeutic strategy for the treatment of symptoms derived from cholinergic degeneration in PD...
December 2016: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/27721206/the-cortical-thickness-correlates-of-clinical-manifestations-in-the-mid-stage-sporadic-parkinson-s-disease
#17
Xia Deng, Chun-Yan Tang, Jie Zhang, Lei Zhu, Zun-Chun Xie, Hong-Han Gong, Xiang-Zuo Xiao, Ren-Shi Xu
The cortical thickness has gained an extensive attention as a pathological alteration of sporadic Parkinson's disease (sPD), the alteration of pathological cortical thickness may distinctly contribute to the consistent clinical manifestations. Therefore, we investigated the cortical thickness correlates of clinical manifestations in the mid-stage sPD from the Han population of Chinese mainland (HPCM). A sample of 67 mid-stage sPD patients and 35 matched controls from HPCM were performed a corticometry of magnetic resonance imaging (MRI) and the assessment of clinical manifestations including the demographic and disease-related characteristics, and underwent the final analysis of the cortical thickness correlates with the clinical manifestations...
October 28, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27681148/adverse-drug-reactions-associated-with-antiretroviral-therapy-in-south-africa
#18
Sumeshni Birbal, Mukesh Dheda, Elizabeth Ojewole, Frasia Oosthuizen
South Africa has one of the highest prevalences of HIV and AIDS in the world. HIV/AIDS patients face countless challenges, one of which is the risk of adverse drug reactions (ADRs). This study aimed to describe the ADRs reported in South Africa with reference to the type of ADRs, antiretrovirals (ARVs) implicated, seriousness of the ADRs and patient demographics associated with specific ADRs. A retrospective quantitative study was carried out using ADR reports submitted to the National Department of Health (NDoH) from 1 January 2010 to 31 December 2014...
September 2016: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/27677169/intolerance-of-dolutegravir-containing-cart-regimens-in-real-life-clinical-practice
#19
Mark de Boer, Guido van den Berk, Natasja van Holten, Josephine Oryszczyn, Willemien Dorama, Daoud Ait Moha, Kees Brinkman
OBJECTIVE: Dolutegravir (DGV) is one of the preferred antiretroviral agents in first line cART. Though considered a well-tolerated drug, we aimed to determine the actual rate, timing, and detailed motivation of stopping DGV in a real life clinical setting. DESIGN: a cohort study including all patients that started DGV in two HIV treatment centers in the Netherlands. METHODS: All cART-naïve and cART-experienced patients who had started DGV were identified from the institutional HIV-databases...
September 24, 2016: AIDS
https://www.readbyqxmd.com/read/27647317/association-between-resting-state-microstates-and-ratings-on-the-amsterdam-resting-state-questionnaire
#20
Evaldas Pipinis, Sigita Melynyte, Thomas Koenig, Lina Jarutyte, Klaus Linkenkaer-Hansen, Osvaldas Ruksenas, Inga Griskova-Bulanova
There is a gap in understanding on how physiologically observed activity is related to the subjective, internally oriented experience during resting state. Microstate analysis is a frequent approach to evaluate resting-state EEG. But the relationship of commonly observed resting-state microstates to psychological domains of resting is not clear. The Amsterdam Resting-State Questionnaire (ARSQ) was recently introduced, offering an effective way to quantify subjective states after a period of resting and associate these quantifiers to psychological and physiological variables...
September 19, 2016: Brain Topography
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