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https://www.readbyqxmd.com/read/28720127/parasomnia-overlap-disorder-parkinson-s-disease-and-subthalamic-deep-brain-stimulation-three-case-reports
#1
Panagiotis Bargiotas, Julia Muellner, W M Michael Schuepbach, Claudio L Bassetti
BACKGROUND: Parasomnia overlap disorder (POD) is a distinct parasomnia and characterized by concomitant manifestation of rapid-eye-movement (REM)- and non-REM (NREM)-parasomnias. Although not uncommon among patients with Parkinson's disease, POD is often under-investigated. CASE PRESENTATION: This is the first report of patients with PD and features of POD that underwent deep brain stimulation. Our patients exhibited different outcomes of POD features after subthalamic deep brain stimulation...
July 18, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28716237/long-term-follow-up-on-quality-of-life-and-its-relationship-to-motor-and-cognitive-functions-in-parkinson-s-disease-after-deep-brain-stimulation
#2
Tatsuya Yamamoto, Tomoyuki Uchiyama, Yoshinori Higuchi, Masato Asahina, Shigeki Hirano, Yoshitaka Yamanaka, Liu Weibing, Satoshi Kuwabara
INTRODUCTION: We aimed to examine temporal changes in health-related quality of life (HRQOL) and its relationship with motor and cognitive functions in patients with Parkinson's disease (PD) after subthalamic nucleus deep brain stimulation (STN-DBS). METHODS: In total, 31 patients with PD were enrolled in this study (mean age: 66.7±0.9years; mean disease duration: 11.6±3.7years). Participants completed the Unified Parkinson's Disease Rating Scale and the Parkinson's Disease Questionnaire-39...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28712841/long-term-impact-of-subthalamic-stimulation-on-cognitive-function-in-patients-with-advanced-parkinson-s-disease
#3
M Acera, A Molano, B Tijero, G Bilbao, I Lambarri, R Villoria, J Somme, E Ruiz de Gopegui, I Gabilondo, J C Gomez-Esteban
OBJECTIVE: The aim of this study was to evaluate the effects of deep brain stimulation of the subthalamic nucleus (DBS-SN) on cognitive function in patients with Parkinson's disease (PD) 5 years after surgery. MATERIAL AND METHODS: We conducted a prospective study including 50 patients with PD who underwent DBS-SN (62.5% were men; mean age of 62.2±8.2 years; mean progression time of 14.1±6.3 years). All patients were assessed before the procedure and at one year after surgery; 40 patients were further followed up until the 5-year mark...
July 13, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/28711737/subthalamic-deep-brain-stimulation-sweet-spots-and-hyperdirect-cortical-connectivity-in-parkinson-s-disease
#4
Harith Akram, Stamatios N Sotiropoulos, Saad Jbabdi, Dejan Georgiev, Philipp Mahlknecht, Jonathan Hyam, Thomas Foltynie, Patricia Limousin, Enrico De Vita, Marjan Jahanshahi, Marwan Hariz, John Ashburner, Tim Behrens, Ludvic Zrinzo
OBJECTIVES: Firstly, to identify subthalamic region stimulation clusters that predict maximum improvement in rigidity, bradykinesia and tremor, or emergence of side-effects; and secondly, to map-out the cortical fingerprint, mediated by the hyperdirect pathways which predict maximum efficacy. METHODS: High angular resolution diffusion imaging in twenty patients with advanced Parkinson's disease was acquired prior to bilateral subthalamic nucleus deep brain stimulation...
July 12, 2017: NeuroImage
https://www.readbyqxmd.com/read/28706748/comparison-of-globus-pallidus-interna-and-subthalamic-nucleus-in-deep-brain-stimulation-for-parkinson-disease-an-institutional-experience-and-review
#5
REVIEW
Shazia Mirza, Umar Yazdani, Richard Dewey Iii, Neepa Patel, Richard B Dewey, Svjetlana Miocinovic, Shilpa Chitnis
Deep Brain Stimulation (DBS) has revolutionized the lives of patients of Parkinson disease, offering therapeutic options to those not benefiting entirely from medications alone. With its proven track record of outperforming the best medical management, the goal is to unlock the full potential of this therapy. Currently, the Globus Pallidus Interna (GPi) and Subthalamic Nucleus (STN) are both viable targets for DBS, and the choice of site should focus on the constellation of symptoms, both motor and nonmotor, which are key determinants to quality of life...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28705699/posterolateral-trajectories-favor-a-longer-motor-domain-in-stn-dbs-for-parkinson-s-disease
#6
Idit Tamir, Odeya Marmor-Levin, Renana Eitan, Hagai Bergman, Zvi Israel
OBJECTIVE: The clinical outcome of Parkinson's disease (PD) patients that undergo Subthalamic Nucleus Deep Brain Stimulation (STN DBS) is, in part, determined by the length of the electrode trajectory through the motor STN domain, the Dorso-Lateral Oscillatory Region (DLOR). Trajectory length has been found to correlate with the stimulation-related improvement in patients' motor function (estimated by part III of the United Parkinson's Disease Rating Score (UPDRS)). Therefore, it seems that ideally trajectories should have maximal DLOR length...
July 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28701941/rapid-alleviation-of-parkinson-s-disease-symptoms-via-electrostimulation-of-intrinsic-auricular-muscle-zones
#7
Yusuf O Cakmak, Hülya Apaydin, Güneş Kiziltan, Ayşegül Gündüz, Burak Ozsoy, Selim Olcer, Hakan Urey, Ozgur O Cakmak, Yasemin G Ozdemir, Sibel Ertan
Background: Deep brain stimulation of the subthalamic nucleus (STN-DBS) and the pedunculopontine nucleus (PPN) significantly improve cardinal motor symptoms and postural instability and gait difficulty, respectively, in Parkinson's disease (PD). Objective and Hypothesis: Intrinsic auricular muscle zones (IAMZs) allow the potential to simultaneously stimulate the C2 spinal nerve, the trigeminal nerve, the facial nerve, and sympathetic and parasympathetic nerves in addition to providing muscle feedback and control areas including the STN, the PPN and mesencephalic locomotor regions...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28701061/subthalamic-nucleus-and-globus-pallidus-internus-stimulation-for-the-treatment-of-parkinson-s-disease-a-systematic-review
#8
Hao Xu, Feng Zheng, Boris Krischek, Wanhai Ding, Chi Xiong, Xin Wang, Chaoshi Niu
Objective Deep brain stimulation (DBS) for treatment of advanced Parkinson's disease (PD) has two anatomical targets: the subthalamic nucleus (STN) and the globus pallidus internus (GPI). The clinical effectiveness of these two stimulation targets was compared in the present study. Methods A systematic review and meta-analysis was performed to evaluated the postoperative changes in the United Parkinson's Disease Rating Scale (UPDRS) on- and off-phase, on-stimulation motor scores; activities of daily living score (ADLS); and levodopa equivalent dose (LED) after STN and GPI stimulation...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28699067/intraoperative-clinical-testing-overestimates-the-therapeutic-window-of-the-permanent-dbs-electrode-in-the-subthalamic-nucleus
#9
Josefine Blume, J Schlaier, E Rothenfußer, J Anthofer, F Zeman, A Brawanski, U Bogdahn, M Lange
BACKGROUND: Intraoperative test stimulation is established to optimize target localization in STN DBS, but requires a time-consuming awake surgery in off-medication state. The aim of this study was to compare the thresholds of stimulation-induced effects of test stimulation and the permanent electrode. METHODS: Fifty-nine PD patients receiving bilateral STN DBS were clinically examined with stepwise increasing monopolar stimulation during surgery and DBS programming at matched stimulation depths...
July 12, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28693077/-influence-of-subthalamic-nucleus-deep-brain-stimulation-on-cognition-and-acetylcholine-in-a-rat-model-of-parkinson-s-disease
#10
Y Xie, X B Du, J Y Liang, J S Xiao, J J Zhang
Objective: To illustrate the effect of subthalamic nucleus deep brain stimulation (STN-DBS)on cognitionand its underlying mechanisms in a rat model of Parkinson's disease (PD). Methods: Thirty healthy male Sprague-Dawley rats were randomly divided into 3 groups: control group (healthy rats, n=10), model group (PD rats, n=10), and stimulation group (PD rats receiving high frequency stimulation, n=10). The cognitive functionof rats was tested through Morris water maze and acetylcholine levels in cortex, hippocampus and striatum have been examined through ELISA...
July 4, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28691164/pick-s-disease-with-neuronal-four-repeat-tau-accumulation-in-the-basal-ganglia-brain-stem-nuclei-and-cerebellum
#11
Chikako Ikeda, Osamu Yokota, Tomoko Miki, Shintaro Takenoshita, Hideki Ishizu, Yoko Mori, Kiyohiro Yamazaki, Yuki Ozaki, Shu-Ichi Ueno, Takeshi Ishihara, Masato Hasegawa, Seishi Terada, Norihito Yamada
It is very rare that cases of Pick's disease, a representative three-repeat (3R) tauopathy, also have significant four-repeat (4R) tau accumulation. Here, we report a Pick's disease case that clinically showed behavioral variant frontotemporal dementia without motor disturbance during the course, and pathologically had 3R tau-positive Pick bodies as well as numerous 4R tau-positive neuronal cytoplasmic inclusions (NCIs). Abundant 3R tau-positive 4R tau-negative spherical or horseshoe-shaped Pick bodies were found in the frontotemporal cortex, limbic region, striatum and pontine nucleus...
July 9, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28684915/effects-of-subthalamic-nucleus-deep-brain-stimulation-on-emotional-working-memory-capacity-and-mood-in-patients-with-parkinson-s-disease
#12
Angela Merkl, Eva Röck, Tanja Schmitz-Hübsch, Gerd-Helge Schneider, Andrea A Kühn
BACKGROUND: In Parkinson's disease (PD), cognitive symptoms and mood changes may be even more distressing for the patient than motor symptoms. OBJECTIVE: Our aim was to determine the effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on working memory (WM) and mood. METHODS: Sixteen patients with PD were assessed with STN-DBS switched on (DBS-ON) and with dopaminergic treatment (Med-ON) compared to switched off (DBS-OFF) and without dopaminergic treatment (Med-OFF)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28676842/subthalamic-nucleus-deep-brain-stimulation-in-early-stage-parkinson-s-disease-is-not-associated-with-increased-body-mass-index
#13
Sarah H Millan, Mallory L Hacker, Maxim Turchan, Anna L Molinari, Amanda D Currie, David Charles
Previous studies suggest that deep brain stimulation of the subthalamic nucleus (STN-DBS) for Parkinson's disease (PD) leads to weight gain. This study analyzes changes in body mass index (BMI) in 29 subjects from a prospective, single-blind trial of DBS in early stage PD (age 50-75, Hoehn & Yahr stage II off medication, treated with antiparkinsonian medications for ≥6 months but <4 years, and without a history of motor fluctuations, dyskinesias, or dementia). Subjects were randomized to DBS plus optimal drug therapy (DBS+ODT; n = 15) or ODT (n = 14) and followed for 24 months...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28676738/the-multiple-correspondence-analysis-method-and-brain-functional-connectivity-its-application-to-the-study-of-the-non-linear-relationships-of-motor-cortex-and-basal-ganglia
#14
Clara Rodriguez-Sabate, Ingrid Morales, Alberto Sanchez, Manuel Rodriguez
The complexity of basal ganglia (BG) interactions is often condensed into simple models mainly based on animal data and that present BG in closed-loop cortico-subcortical circuits of excitatory/inhibitory pathways which analyze the incoming cortical data and return the processed information to the cortex. This study was aimed at identifying functional relationships in the BG motor-loop of 24 healthy-subjects who provided written, informed consent and whose BOLD-activity was recorded by MRI methods. The analysis of the functional interaction between these centers by correlation techniques and multiple linear regression showed non-linear relationships which cannot be suitably addressed with these methods...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28676310/an-investigation-into-the-effects-and-prognostic-factors-of-cognitive-decline-following-subthalamic-nucleus-stimulation-in-patients-with-parkinson-s-disease
#15
Taro Nimura, Ken-Ichi Nagamatsu, Tadashi Ando, Arifumi Matsumoto, Kinya Hisanaga, Teiji Tominaga
We retrospectively investigated the effects of subthalamic nucleus stimulation (STN-DBS) on new postoperative onset of cognitive decline and prognostic factors for advanced Parkinson's disease (PD). We studied 39 PD patients who had received bilateral STN-DBS. Clinical symptoms, cognitive function, psychiatric function, and health-related quality of life (HRQOL) were assessed before and six months after surgery. Based on the results of neuropsychological examinations six months after the surgery, the subjects were divided into those with and those without cognitive decline...
July 1, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28669542/opposite-effects-of-l-dopa-and-dbs-stn-on-saccadic-eye-movements-in-advanced-parkinson-s-disease
#16
Małgorzata Dec-Ćwiek, Marcin Tutaj, Jean-Michel Gracies, Jens Volkmann, Monika Rudzińska, Agnieszka Słowik, Andrzej Szczudlik
OBJECTIVE: To assess the effects of l-dopa and deep brain stimulation of the subthalamic nucleus (DBS-STN) on saccadic eye movements in patients with Parkinson's disease (PD). METHODS: Visually and internally guided horizontal saccades were evaluated using a saccadometer in 64 patients with advanced PD and 48 healthy controls. Forty-four pharmacologically treated patients were assessed in their "med-off" (OFF) and "med-on" (ON) status, whereas 20 DBS-STN treated patients were assessed in their "med-off, stim-off" (OFF) and "med-off, stim-on" (ON) status...
June 24, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28665252/deep-brain-stimulation-for-parkinson-s-disease-meta-analysis-of-results-of-randomized-trials-at-varying-lengths-of-follow-up
#17
Alireza Mansouri, Shervin Taslimi, Jetan H Badhiwala, Christopher D Witiw, Farshad Nassiri, Vincent J J Odekerken, Rob M A De Bie, Suneil K Kalia, Mojgan Hodaie, Renato P Munhoz, Alfonso Fasano, Andres M Lozano
OBJECTIVE Deep brain stimulation (DBS) is effective in the management of patients with advanced Parkinson's disease (PD). While both the globus pallidus pars interna (GPi) and the subthalamic nucleus (STN) are accepted targets, their relative efficacy in randomized controlled trials (RCTs) has not been established beyond 12 months. The objective of this study was to conduct a meta-analysis of RCTs to compare outcomes among adults with PD undergoing DBS of GPi or STN at various time points, including 36 months of follow-up...
June 30, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28664016/delayed-onset-eye-opening-apraxia-due-to-progression-of-brain-atrophy-following-subthalamic-nucleus-deep-brain-stimulation-a-case-report
#18
Takashi Morishita, Masa-Aki Higuchi, Yoshio Tsuboi, Kazuhiro Samura, Tooru Inoue
Eye opening apraxia (EOA) has been described in literature as a complication of deep brain stimulation (DBS), especially after electrode implantation in the subthalamic nucleus (STN). EOA can be either worsened or alleviated by DBS depending on the etiology. Herein, we report a rare case where the progression of brain atrophy may have contributed to the delayed onset of EOA. The patient, a 73-year-old woman, had previously undergone bilateral STN-DBS for advanced Parkinson's disease (PD), which was performed by another DBS team, at the age of 68 years...
January 2017: NMC Case Rep J
https://www.readbyqxmd.com/read/28663091/locomotion-in-intact-and-in-brain-cortex-ablated-cats
#19
José Roberto López Ruiz, Luis Castillo Hernández, Braniff De la Torre Valdovinos, Nancy Elizabeth Franco Rodríguez, Judith Marcela Dueñas Jiménez, Alejandro Dueñas Jiménez, Jorge David Rivas-Carrillo, Sergio Horacio Dueñas Jiménez
The current decerebration procedures discard the role of the thalamus in the motor control and decortication only rules out the brain cortex part, leaving a gap between the brain cortex and the subthalamic motor regions. In here we define a new preparation denominated Brain Cortex-Ablated Cat (BCAC), in which the frontal and parietal brain cortices as well as the central white matter beneath them were removed, this decerebration process may be considered as suprathalamic, since the thalamus remained intact...
June 27, 2017: Neuroscience
https://www.readbyqxmd.com/read/28643887/personality-dopamine-and-parkinson-s-disease-insights-from-subthalamic-stimulation
#20
Eugénie Lhommée, François Boyer, Maxime Wack, Pierre Pélissier, Hélène Klinger, Emmanuelle Schmitt, Amélie Bichon, Valérie Fraix, Stéphan Chabardès, Patrick Mertens, Anna Castrioto, Andrea Kistner, Emmanuel Broussolle, Stéphane Thobois, Paul Krack
BACKGROUND: Subthalamic stimulation improves the motor and neuropsychiatric symptoms of Parkinson's disease. However, the impact of this treatment on impulse control and personality is the subject of heavy debate. The objective of this study was to investigate personality changes after subthalamic stimulation. METHODS: Using Cloninger's biosocial model, we assessed personality in 73 Parkinson's disease patients before and 12 months after subthalamic stimulation accompanied by a drastic reduction in dopaminergic medication...
June 23, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
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