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https://www.readbyqxmd.com/read/28334851/the-modulatory-effect-of-adaptive-deep-brain-stimulation-on-beta-bursts-in-parkinson-s-disease
#1
Gerd Tinkhauser, Alek Pogosyan, Simon Little, Martijn Beudel, Damian M Herz, Huiling Tan, Peter Brown
Adaptive deep brain stimulation uses feedback about the state of neural circuits to control stimulation rather than delivering fixed stimulation all the time, as currently performed. In patients with Parkinson's disease, elevations in beta activity (13-35 Hz) in the subthalamic nucleus have been demonstrated to correlate with clinical impairment and have provided the basis for feedback control in trials of adaptive deep brain stimulation. These pilot studies have suggested that adaptive deep brain stimulation may potentially be more effective, efficient and selective than conventional deep brain stimulation, implying mechanistic differences between the two approaches...
February 13, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28334424/frequency-and-function-in-the-basal-ganglia-the-origins-of-beta-and-gamma-band-activity
#2
Alexander Blenkinsop, Sean Anderson, Kevin Gurney
Neural oscillations in the basal ganglia are well studied yet remain poorly understood. Behavioural correlates of spectral activity are well described, yet a quantitative hypothesis linking time domain dynamics and spectral properties to basal ganglia function has been lacking. We show, for the first time, that a unified description is possible by interpreting previously ignored structure in data describing GPi responses to cortical stimulation. These data were used to expose a pair of distinctive neuronal responses to the stimulation...
March 23, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28323092/the-effect-of-deep-brain-stimulation-of-the-subthalamic-nucleus-on-executive-functions-impaired-verbal-fluency-and-intact-updating-planning-and-conflict-resolution-in-parkinson-s-disease
#3
Gyula Demeter, István Valálik, Péter Pajkossy, Agnes Szőllősi, Ágnes Lukács, Ferenc Kemény, Mihály Racsmány
Although the improvement of motor symptoms in Parkinson's disease (PD) after Deep Brain Stimulation (DBS) of the subthalamic nucleus (STN) is well documented, there are open questions regarding its impact on cognitive functions. The aim of the present study was to assess the effect of bilateral DBS of the STN on executive functions in PD patients using a DBS wait-listed PD control group. Ten PD patients with DBS implantation (DBS group) and ten PD wait-listed patients (Clinical control group) participated in the study...
March 18, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28303790/design-of-robust-adaptive-controller-and-feedback-error-learning-for-rehabilitation-in-parkinson-s-disease-a-simulation-study
#4
Korosh Rouhollahi, Mehran Emadi Andani, Seyed Mahdi Karbassi, Iman Izadi
Deep brain stimulation (DBS) is an efficient therapy to control movement disorders of Parkinson's tremor. Stimulation of one area of basal ganglia (BG) by DBS with no feedback is the prevalent opinion. Reduction of additional stimulatory signal delivered to the brain is the advantage of using feedback. This results in reduction of side effects caused by the excessive stimulation intensity. In fact, the stimulatory intensity of controllers is decreased proportional to reduction of hand tremor. The objective of this study is to design a new controller structure to decrease three indicators: (i) the hand tremor; (ii) the level of delivered stimulation in disease condition; and (iii) the ratio of the level of delivered stimulation in health condition to disease condition...
February 2017: IET Systems Biology
https://www.readbyqxmd.com/read/28303202/effects-of-deep-brain-stimulation-on-vocal-fold-immobility-in-parkinson-s-disease
#5
Elsa V Arocho-Quinones, Michael J Hammer, Jonathan M Bock, Peter A Pahapill
BACKGROUND: Vocal fold (VF) immobility is a rare, potentially fatal complication of advanced Parkinson's disease (PD). Previous reports suggest that subthalamic nucleus deep brain stimulation (STN-DBS) may influence laryngeal function, yet the role of STN-DBS on VF immobility remains unexplored. CASE DESCRIPTION: We report a case of a patient with advanced PD and bilateral VF immobility ultimately requiring a tracheostomy. To assess the effects of STN-DBS on vocal cord function and to correlate these effects with peripheral motor symptoms at different stimulation settings, the patient was evaluated before and after initiation of bilateral STN-DBS...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28293179/disynaptic-subthalamic-input-to-the-posterior-cerebellum-in-rat
#6
Saad Jwair, Patrice Coulon, Tom J H Ruigrok
In the last decade, the interplay between basal ganglia and cerebellar functions has been increasingly advocated to explain their joint operation in both normal and pathological conditions. Yet, insight into the neuroanatomical basis of this interplay between both subcortical structures remains sparse and is mainly derived from work in primates. Here, in rodents, we have studied the existence of a potential disynaptic connection between the subthalamic nucleus (STN) and the cerebellar cortex as has been demonstrated earlier for the primate...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28292695/neurosurgical-relevance-of-the-dissection-of-the-diencephalic-white-matter-tracts-using-the-klingler-technique
#7
Susana M Silva, Diogo Cunha-Cabral, José Paulo Andrade
OBJECTIVE: The Klingler fiber dissection technique is a relevant and reliable method for neurosurgery to identify with accuracy the fine structure of the brain anatomy highlighting white matter tracts. In order to demonstrate the significance of the application of this technique, we aimed to observe the course and relations of the mammillothalamic and habenulo-interpeduncular tracts as there are very few papers showing these important diencephalic tracts. MATERIAL AND METHODS: Twelve formalin-fixed brains were dissected using the Klingler technique in order to expose the medial diencephalic surface...
March 2, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28283867/postoperative-neuroimaging-analysis-of-drt-deep-brain-stimulation-revision-surgery-for-complicated-essential-tremor
#8
Volker Arnd Coenen, Balint Varkuti, Yaroslav Parpaley, Sabine Skodda, Thomas Prokop, Horst Urbach, Meng Li, Peter Christoph Reinacher
BACKGROUND: We report a patient who received conventional bilateral deep brain stimulation of the ventral intermediate nucleus of thalamus (Vim) for the treatment of medication refractory essential tremor (ET). After initial beneficial effects, therapeutic efficacy was lost due to a loss of control of his proximal trunkal and extremity tremor. The patient received successful diffusion tensor magnetic resonance imaging fiber tractographic (DTI FT)-assisted DBS revision surgery targeting the dentato-rubro-thalamic tract (DRT) in the subthalamic region (STR)...
March 10, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28282816/my-25-stimulating-years-with-dbs-in-parkinson-s-disease
#9
Marwan Hariz
The year 2017 marks the 30th anniversary of the birth of modern deep brain stimulation (DBS), which was introduced by Benabid, Pollak et al. in 1987, initially targeting the motor thalamus to treat tremor, and subsequently targeting the subthalamic nucleus (STN) for treatment of symptoms of advanced Parkinson's disease (PD). STN DBS is undoubtedly "the most important discovery since levodopa", as stated by David Marsden in 1994. In 2014, The Lasker- DeBakey Clinical Medical Research Award to "honor two scientists who developed deep brain stimulation of the subthalamic nucleus", was bestowed upon Benabid and DeLong...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28275542/parkinson-s-disease-diffusion-mri-is-not-affected-by-acute-antiparkinsonian-medication
#10
Jae Woo Chung, Roxana G Burciu, Edward Ofori, Priyank Shukla, Michael S Okun, Christopher W Hess, David E Vaillancourt
OBJECTIVE: A prior longitudinal study demonstrates that free-water diffusion magnetic resonance imaging (dMRI) tracks progression in the substantia nigra (Ofori et al., 2015b). Here, we test the acute effects of antiparkinsonian medication on this established imaging progression marker for the first time. METHODS: Fifteen PD patients underwent dMRI OFF and ON-medication one day apart. ON-medication, patients were tested approximately 45 min after their usual dose of antiparkinsonian medication...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28269510/network-effects-and-pathways-in-deep-brain-stimulation-in-parkinson-s-disease
#11
N Koirala, V Fleischer, O Granert, G Deuschl, M Muthuraman, S Groppa
Deep brain stimulation of subthalamic nucleus (STN-DBS) became a standard therapeutic option in Parkinson's disease (PD), even though the underlying modulated network of STN-DBS is still poorly described. Probabilistic tractography and connectivity analysis as derived from diffusion tensor imaging (DTI) were performed together with modelling of implanted electrode positions and linked postoperative clinical outcome. Fifteen patients with idiopathic PD without dementia were selected for DBS treatment. After pre-processing, probabilistic tractography was run from cortical and subcortical seeds of the hypothesized network to targets represented by the positions of the active DBS contacts...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269504/synchronization-of-brain-activity-during-induction-of-propofol-anesthesia-comparison-of-methods
#12
Tarmo Lipping, Jaanika Saareleht, Elzbieta Olejarczyk, Eila Sonkajarvi, Tuomo Ylinen, Ville Jantti
Synchrony patterns between the EEG measured from the subthalamic nucleus and scalp are analyzed during induction of propofol anesthesia. Various methods such as Coherence, Phase Locking Value, Partial Directed Coherence, Mutual Information, and Transfer Entropy are applied. The results indicate that, in general, the synchrony patterns seen in the depth-scalp electrode pair are similar to those seen between two scalp electrodes of opposite hemispheres. A clear change of state is revealed at about 10 minutes before burst suppression; this event is revealed by linear (Coherence) as well as nonlinear (Phase Locking Value) and information theoretic (Mutual Information and Transfer Entropy) measures...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268500/a-multiple-kernel-learning-approach-for-human-behavioral-task-classification-using-stn-lfp-signal
#13
Hosein M Golshan, Adam O Hebb, Sara J Hanrahan, Joshua Nedrud, Mohammad H Mahoor
Deep Brain Stimulation (DBS) has gained increasing attention as an effective method to mitigate Parkinson's disease (PD) disorders. Existing DBS systems are open-loop such that the system parameters are not adjusted automatically based on patient's behavior. Classification of human behavior is an important step in the design of the next generation of DBS systems that are closed-loop. This paper presents a classification approach to recognize such behavioral tasks using the subthalamic nucleus (STN) Local Field Potential (LFP) signals...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268291/comparison-of-imaging-modalities-and-source-localization-algorithms-in-locating-the-induced-activity-during-deep-brain-stimulation-of-the-stn
#14
K G Mideksa, A Singh, N Hoogenboom, H Hellriegel, H Krause, A Schnitzler, G Deuschl, J Raethjen, G Schmidt, M Muthuraman
One of the most commonly used therapy to treat patients with Parkinson's disease (PD) is deep brain stimulation (DBS) of the subthalamic nucleus (STN). Identifying the most optimal target area for the placement of the DBS electrodes have become one of the intensive research area. In this study, the first aim is to investigate the capabilities of different source-analysis techniques in detecting deep sources located at the sub-cortical level and validating it using the a-priori information about the location of the source, that is, the STN...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28264233/striatal-glutamate-and-gaba-after-high-frequency-subthalamic-stimulation-in-parkinsonian-rat
#15
Kyung Jin Lee, Insop Shim, Jae Hoon Sung, Jae Taek Hong, Il Sup Kim, Chul Bum Cho
OBJECTIVE: High frequency stimulation (HFS) of the subthalamic nucleus (STN) is recognized as an effective treatment of advanced Parkinson's disease. However, the neurochemical basis of its effects remains unknown. The aim of this study is to investigate the effects of STN HFS in intact and 6-hydroxydopamine (6-OHDA)-lesioned hemiparkinsonian rat model on changes of principal neurotransmitters, glutamate, and gamma-aminobutyric acid (GABA) in the striatum. METHODS: The authors examined extracellular glutamate and GABA change in the striatum on sham group, 6-OHDA group, and 6-OHDA plus deep brain stimulation (DBS) group using microdialysis methods...
March 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28263159/-dyskinesia-in-parkinson-s-disease-an-update-on-new-neuroimaging-methods-and-treatment-possibilities
#16
Birgitte Liang Chen Thomsen, Damian Marc Herz, Hartwig Roman Siebner, Annemette Løkkegaard
Levodopa-induced dyskinesia (LID) represents a severe adverse effect of long-term treatment of Parkinson's disease with levodopa. Neuroimaging studies have contributed to our understanding of LID and may help to identify patients at risk of developing LID. Amantadine can be used for the treatment of LID, and novel drugs are under development. Deep brain stimulation of the subthalamic nucleus and globus pallidus internus alleviates LID, the former indirectly by reducing levodopa intake, the latter through direct effects...
March 6, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28262813/effects-of-dbs-in-parkinsonian-patients-depend-on-the-structural-integrity-of-frontal-cortex
#17
Muthuraman Muthuraman, Günther Deuschl, Nabin Koirala, Christian Riedel, Jens Volkmann, Sergiu Groppa
While deep brain stimulation of the subthalamic nucleus (STN-DBS) has evolved to an evidence-based standard treatment for Parkinson's disease (PD), the targeted cerebral networks are poorly described and no objective predictors for the postoperative clinical response exist. To elucidate the systemic mechanisms of DBS, we analysed cerebral grey matter properties using cortical thickness measurements and addressed the dependence of structural integrity on clinical outcome. Thirty one patients with idiopathic PD without dementia (23 males, age: 63...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28259880/modified-fluorodeoxyglucose-metabolism-in-motor-circuitry-by-subthalamic-deep-brain-stimulation
#18
Chunyan Cao, Huiwei Zhang, Dianyou Li, Shikun Zhan, Jing Zhang, Xiaoxiao Zhang, Chuantao Zuo, Bomin Sun
BACKGROUND: Adjustment of the motor circuitry has been described in the treatment of Parkinson disease (PD). OBJECTIVES: To evaluate the modulation of the motor circuitry of PD patients by subthalamic deep brain stimulation (STN DBS) using 18F-fluorodeoxyglucose (FDG) and positron emission tomography (PET). METHODS: Resting-state brain 18F-FDG PET imaging was performed for 8 PD patients before surgery and also 1 year after STN DBS treatment; changes in regional glucose metabolism were identified...
March 4, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28258925/parkinsonian-gait-improves-with-bilateral-subthalamic-nucleus-deep-brain-stimulation-during-cognitive-multi-tasking
#19
Gaurav Chenji, Melissa L Wright, Kelvin L Chou, Rachael D Seidler, Parag G Patil
BACKGROUND: Gait impairment in Parkinson's disease reduces mobility and increases fall risk, particularly during cognitive multi-tasking. Studies suggest that bilateral subthalamic deep brain stimulation, a common surgical therapy, degrades motor performance under cognitive dual-task conditions, compared to unilateral stimulation. OBJECTIVE: To measure the impact of bilateral versus unilateral subthalamic deep brain stimulation on walking kinematics with and without cognitive dual-tasking...
February 24, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28246572/impact-of-combined-subthalamic-nucleus-and-substantia-nigra-stimulation-on-neuropsychiatric-symptoms-in-parkinson-s-disease-patients
#20
U Hidding, A Gulberti, A Horn, C Buhmann, W Hamel, J A Koeppen, M Westphal, A K Engel, C Gerloff, D Weiss, C K E Moll, M Pötter-Nerger
The goal of the study was to compare the tolerability and the effects of conventional subthalamic nucleus (STN) and combined subthalamic nucleus and substantia nigra (STN+SNr) high-frequency stimulation in regard to neuropsychiatric symptoms in Parkinson's disease patients. In this single center, randomized, double-blind, cross-over clinical trial, twelve patients with advanced Parkinson's disease (1 female; age: 61.3 ± 7.3 years; disease duration: 12.3 ± 5.4 years; Hoehn and Yahr stage: 2.2 ± 0.39) were included...
2017: Parkinson's Disease
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