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Safoura Seifi, Shabnam Sohanian, Oveis Khakbaz, Farida Abesi, Fatemeh Aliakbarpour, Arezoo Rayani
INTRODUCTION: The ectopic ciliated cyst is a rare non-odontogenic cyst which occurs as a delayed complication after maxillary sinus radical surgery; this lesion emerges due to the destruction of the sinus mucosa during the surgery and entrapment of the respiratory epithelium in the region. This lesion has been observed in very rare cases following genioplasty and bimaxillary orthognathic surgery. CASE REPORT: We reported a case of the ectopic ciliated cyst in in the mandible of a 37-year-old Iranian woman following genioplasty and Lefort 1 surgery after 2 years...
September 2016: Iranian Journal of Otorhinolaryngology
Julien Crovadore, Bastien Cochard, Gautier Calmin, Romain Chablais, Torsten Schulz, François Lefort
We report here the whole-genome shotgun sequences of the strain UASWS1009 of the species Mesorhizobium hungaricum sp. nov., which are different from any other known Mesorhizobium species. This is the first genome registered for this new species, which could be considered as a potential resource for agriculture and environmental uses.
October 13, 2016: Genome Announcements
Julien Crovadore, Bastien Cochard, Gautier Calmin, Romain Chablais, Torsten Schulz, François Lefort
We report here the whole-genome shotgun sequence of the strain UASWS0955 of the species Pseudomonas xanthomarina, isolated from sewage sludge. This genome was obtained with an Illumina MiniSeq and is the second genome registered for this species, which is considered as a promising resource for agriculture and bioremediation of contaminated soils.
October 13, 2016: Genome Announcements
S Gérard, D Bréchemier, A Lefort, S Lozano, G Abellan Van Kan, T Filleron, L Mourey, C Bernard-Marty, M E Rougé-Bugat, V Soler, B Vellas, M Cesari, Y Rolland, L Balardy
BACKGROUND: The estimation of the risk of poor tolerance and overdose of antineoplastic agents protocols represents a major challenge in oncology, particularly in older patients. We hypothesize that age-related modifications of body composition (i.e. increased fat mass and decreased lean mass) may significantly affect tolerance to chemotherapy. METHOD: We conducted a systematic review for the last 25 years (between 1990 and 2015), using US National library of Medicine Medline electronic bibliographic database and Embase database of cohorts or clinical trials exploring (i) the interactions of body composition (assessed by Dual X-ray Absorptiometry, Bioelectrical Impedance Analyses, or Computerized Tomography) with pharmacokinetics parameters, (ii) the tolerance to chemotherapy, and (iii) the consequences of chemotherapies or targeted therapies on body composition...
2016: Journal of Nutrition, Health & Aging
S Lefort, A Thuleau, Y Kieffer, P Sirven, I Bieche, E Marangoni, A Vincent-Salomon, F Mechta-Grigoriou
The CXCR4 receptor and its ligand CXCL12 (also named stromal cell-derived factor 1, SDF1) have a critical role in chemotaxis and homing, key steps in cancer metastasis. Although myofibroblasts expressing CXCL12 are associated with the presence of axillary metastases in HER2 breast cancers (BC), the therapeutic interest of targeting CXCR4/CXCL12 axis in the different BC subtypes remains unclear. Here, we investigate this question by testing antitumor activity of CXCR4 inhibitors in patient-derived xenografts (PDX), which faithfully reproduce human tumor properties...
September 26, 2016: Oncogene
Laura Frangeul, Gabrielle Pouchelon, Ludovic Telley, Sandrine Lefort, Christian Luscher, Denis Jabaudon
Modality-specific sensory inputs from individual sense organs are processed in parallel in distinct areas of the neocortex. For each sensory modality, input follows a cortico-thalamo-cortical loop in which a 'first-order' exteroceptive thalamic nucleus sends peripheral input to the primary sensory cortex, which projects back to a 'higher order' thalamic nucleus that targets a secondary sensory cortex. This conserved circuit motif raises the possibility that shared genetic programs exist across sensory modalities...
September 26, 2016: Nature
G Rossi, E Lafont, L Gasperini, S Dokmak, M Ronot, B Rossi, V Zarrouk, B Fantin, A Lefort
Liver abscess is a rare and severe infection. Incidence increases because of aging of population, advances in liver and biliary surgery including liver transplantation, and immunodeficiency factors. Diagnosis depends mainly on imaging and needle aspiration for microbiological identification. Treatment is based on antibiotics, percutaneous or surgical drainage, and control of the primary source.
September 14, 2016: La Revue de Médecine Interne
Yao Liu, Wen Du, Jing Hu, Chuhang Liao, Wei Fei, En Luo
OBJECTIVE: With the inclusion criteria of patients confirmed and the therapeutic effects and stability evaluated, this article presents the clinical value of bimaxillary orthognathic surgery without bone graft of maxillofacial asymmetric deformities in patients treated for unilateral temporomandibular joint (TMJ) ankylosis. STUDY DESIGN: From 2008 to 2012, 12 patients with dentomaxillofacial asymmetric deformities secondary to unilateral TMJ ankylosis who had undergone TMJ reconstruction as the primary surgery were included in the study...
July 14, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Laurence Balas, Justine Bertrand-Michel, Fanny Viars, Julien Faugere, Corinne Lefort, Sylvie Caspar-Bauguil, Dominique Langin, Thierry Durand
An efficient regiospecific total synthesis of several branched fatty acyl hydroxyl-fatty acids (FAHFA) has been achieved from available terminal alkenes and alkynes. The key steps feature a boron trifluoride mediated epoxide ring opening with acetylide carbanions, followed by hydrogenation of the alkyne function. The carboxylic acid of the hydroxylated chains is introduced at the last step of the synthesis to allow the esterification of the branched hydroxyl group by fatty acids beforehand. The chemical syntheses of a "linear" FAHFA and a branched FAHFA analog containing a Z-olefin in the hydroxyl-fatty acid chain are also reported...
October 14, 2016: Organic & Biomolecular Chemistry
Daoud Dounia, Battison Andrea, Natalie Lefort, Jordana Lynne Van Geest
In Atlantic Canada and other salmon-growing regions, treatment of sea lice infestations in salmon aquaculture is necessary to protect fish health. The product Salmosan®, which contains the organophosphate azamethiphos as the active ingredient, is a pesticide presently used for treatment against sea lice. It is applied as a bath treatment and then released into the surrounding seawater. The potential for lethality to non-target species following acute and chronic exposures to Salmosan® has been studied over the past decade, however, the potential for sublethal effects on lobsters remains a concern...
September 1, 2016: Ecotoxicology and Environmental Safety
David Grégoire, Laura Verdon, Vincent Lefort, Peter Grassl, Jacqueline Saliba, Jean-Pierre Regoin, Ahmed Loukili, Gilles Pijaudier-Cabot
The purpose of this paper is to analyse the development and the evolution of the fracture process zone during fracture and damage in quasi-brittle materials. A model taking into account the material details at the mesoscale is used to describe the failure process at the scale of the heterogeneities. This model is used to compute histograms of the relative distances between damaged points. These numerical results are compared with experimental data, where the damage evolution is monitored using acoustic emissions...
October 25, 2015: International Journal for Numerical and Analytical Methods in Geomechanics
Erica Kristen Ludi, Saurabh Rohatgi, Matthew E Zygmont, Faisal Khosa, Tarek N Hanna
OBJECTIVE: The objective of the present study is to examine the concordance of facial fracture classifications in patients with trauma who underwent surgery and to assess the epidemiologic findings associated with facial trauma. MATERIALS AND METHODS: Patients with trauma who underwent facial CT examination and inpatient operative intervention during a 1-year period were retrospectively analyzed. Patient demographic characteristics, the mechanism of injury, the radiology report, the surgical diagnosis, and clinical indications were reviewed...
August 24, 2016: AJR. American Journal of Roentgenology
Sujeet Dutta, Ronan Lefort, Denis Morineau, Ramona Mhanna, Odile Merdrignac-Conanec, Arnaud Saint-Jalmes, Théo Leclercq
MCM-41 nanoporous silicas show a very high selectivity for monoalcohols over aprotic molecules during adsorption of a binary mixture in the gas phase. We present here an original use of gravimetric vapour sorption isotherms to characterize the role played by the alcohol hydrogen-bonding network in the adsorption process. Beyond simple selectivity, vapour sorption isotherms measured for various compositions help to completely unravel at the molecular level the step by step adsorption mechanism of the binary system in the nanoporous solid, from the first monolayers to the complete liquid condensation...
September 21, 2016: Physical Chemistry Chemical Physics: PCCP
María-Victoria Alvarez-Sanchez, Inés Oria, Olivia B Luna, Jean Pialat, Rodica Gincul, Christine Lefort, Raphael Bourdariat, Fabien Fumex, Vincent Lepilliez, Jean Yves Scoazec, Angel Salgado-Barreira, Anne Isabelle Lemaistre, Bertrand Napoléon
BACKGROUND: The therapeutic role of endoscopic papillectomy (EP) for early ampullary cancer (AC) is still controversial. The aim of the present study was to evaluate the curative potential of EP for early AC and to identify predictors of lymph node metastases (LNMs). METHODS: We retrospectively reviewed 173 patients who were prospectively included in a database and who underwent EP between 1999 and 2013. Adenocarcinoma was present in 28 resected specimens. An additional surgery was proposed in cases of duodenal submucosal infiltration, duct ingrowth, R1 resection or lymphovascular invasion...
August 16, 2016: Surgical Endoscopy
Mohamed Touati, Ludovic Lamarsalle, Stéphane Moreau, Françoise Vergnenègre, Sophie Lefort, Catherine Brillat, Laetitia Jeannet, Aline Lagarde, Annick Daulange, Arnaud Jaccard, Alain Vergnenègre, Dominique Bordessoule
At home injectable chemotherapy for patients receiving treatment for hematological diseases is still in debate. Given the expense of new innovative medicines, at home treatment has been proposed as a suitable option for improving patient quality of life and decreasing treatment costs. We decided to assess the cost of bortezomib administration in France among multiple myeloma patients from an economic standpoint. Patients in this study were treated within a regional hematological network combining outpatient hospital care and Hospital care at Home administration...
August 15, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
S Al-Hajj, A Heraud, C Lefort, L Lamendour, I Kazma, P Gatault, M Buchler, C Baron, J-M- Halimi
OBJECTIVE: Excessive salt intake may result in the development of hypertension. Recent studies indicated that high sodium concentrations polarize the T-cell immune response toward TH17. Moreover, high salt diet increases interstitial sodium concentration (up to 180 mol/L) and skin macrophage and dendritic cell (DC) density. Furthermore, hypertension was shown to be transferable from hypertensive to normotensive animals through infusion of DC from hypertensive animals. However, the effects of high sodium concentration on DC function remain unknown...
September 2016: Journal of Hypertension
Claire Pellot-Barakat, Linda Chami, Jean Michel Correas, Muriel Lefort, Olivier Lucidarme
This study was undertaken to evaluate the impact of free-breathing (FB) vs. Apnea on Shear-wave elastography (SWE) measurements. Quantitative liver-stiffness measurements were obtained during FB and Apnea for 97 patients with various body-morphologies and liver textures. Quality indexes of FB and Apnea elasticity maps (percentage of non-filling (PNF), temporal (TV) and spatial (SV) variabilities) were computed. SWE measurements were also obtained from an homogeneous phantom at rest and during a mechanically-induced motion...
September 2016: European Journal of Radiology
Sandrine Sallé-Lefort, Stéphanie Miard, Marc-André Nolin, Louise Boivin, Marie-Ève Paré, Richard Debigaré, Frédéric Picard
Increased expression levels of the long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (Malat1) have been associated with enhanced proliferation and metastasis of several cancer cell types. Hypoxia, a hallmark characteristic of solid tumors, has been linked to an increase in the activity of the ATP-generating AMPK protein. Since Malat1 was recently shown to be upregulated during hypoxia, the objective of this study was to determine the contribution of AMPK in the mechanistic pathways regulating Malat1 expression in low oxygen conditions...
October 2016: International Journal of Oncology
Hakim Benamer, Sophie Bataille, Muriel Tafflet, Patricia Jabre, François Dupas, François X Laborne, Frédéric Lapostolle, Hugues Lefort, Jean-Michel Juliard, Jean-Yves Letarnec, Lionel Lamhaut, Gaelle Lebail, Thevy Boche, Aurélie Loyeau, Christophe Caussin, Mireille Mapouata, Nicole Karam, Xavie Jouven, Christian Spaulding, Yves Lambert
AIMS: The mortality rate in patients with STEMI is higher in women than in men. This higher mortality rate is partly accounted for by certain known characteristics inherent in the female population (age, diabetes). Using data from the e-MUST registry on STEMI patients in the Greater Paris area, we assessed the differences between men and women treated with reperfusion strategies. METHODS AND RESULTS: Patients presenting within 24 hours of pain onset between 2006 and 2010 were included in the study...
2016: EuroIntervention
E Lafont, L Gasperini, G Rossi, V Zarrouk, B Fantin, A Lefort
No abstract text is available yet for this article.
June 2016: Médecine et Maladies Infectieuses
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