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Elbert E Vaca, Sergey Y Turin, Arun K Gosain
Difficulty with speech intelligibility in Mobius syndrome patients due to bilabial incompetence is common yet rarely discussed. We present a patient with Mobius syndrome who underwent counterclockwise LeFort I impaction to improve her labial competence. In addition, we present a literature review of management strategies for labial incompetence correction in Mobius patients. At 7-year follow-up after LeFort 1 impaction, the patient reports improvement in speech intelligibility, specifically regarding the ability to pronounce bilabial consonants...
January 1, 2018: Cleft Palate-craniofacial Journal
Thibaut Bila, Pierre-Éric Schwartzbrod, Paul-Vincent Martin, Yvan Fronty, Hugues Lefort
No abstract text is available yet for this article.
March 2018: Revue de L'infirmière
Elizabeth G Mann, Margaret B Harrison, Sandra LeFort, Elizabeth G VanDenKerkhof
Individuals with chronic pain with neuropathic characteristics (CPNC) describe a different pain experience compared with those with chronic pain without neuropathic characteristics (CP). The aim of this study was to describe and compare pain, self-management strategies, and satisfaction with ability to control pain between adults with CPNC versus CP. Seven hundred and ten community-dwelling adults with chronic pain participated in a cross-sectional survey. CPNC was defined as a score ≥12 on the Self-Report Leeds Assessment of Neuropathic Symptoms and Signs Pain Scale...
March 1, 2018: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
Sophie Carter, Stéphanie Miard, Alexandre Caron, Sandrine Sallé-Lefort, Philippe St-Pierre, Fernando Forato Anhê, Emilie Lavoie-Charland, Pascale Blais-Lecours, Marie-Claude Drolet, Julie S Lefebvre, Julie Lacombe, Yves Deshaies, Jacques Couet, Mathieu Laplante, Mathieu Ferron, Yohan Bossé, André Marette, Denis Richard, David Marsolais, Frédéric Picard
The current demographic shift toward an aging population has led to a robust increase in the prevalence of age-associated metabolic disorders. Interestingly, recent studies have demonstrated that the etiology of obesity-related insulin resistance developed upon aging differs from that induced by high-calorie diets. Whereas the role of adaptive immunity on the changes in energy metabolism driven by nutritional challenges has gained attention in the past years, its impact upon aging remains mostly unknown. Here, we found that follicular B2 lymphocytes and expression levels of the B cell-specific transcriptional coactivator OcaB increase with age in spleen and in intra-abdominal epididymal white adipose tissue (eWAT), concomitantly with higher circulating levels of immunoglobulin G (IgG) and impaired glucose homeostasis...
March 1, 2018: Diabetes
Florence Zylbersztejn, Mario Flores-Violante, Thibault Voeltzel, Franck-Emmanuel Nicolini, Sylvain Lefort, Véronique Maguer-Satta
The microenvironment (niche) governs the fate of stem cells (SC) by balancing self-renewal and differentiation. Increasing evidence indicates that the tumor niche plays an active role in cancer but its (important) properties for tumor initiation progression and resistance remain to be identified. Clinical data show that leukemic stem cells (LSC) survival is responsible for disease persistence and drug resistance probably due to their sustained interactions with the tumor niche. The Bone Morphogenetic Protein (BMP) signaling is a key pathway controlling stem cells and their niche, such as BMP2 and BMP4 important in both normal and cancer context...
February 22, 2018: Experimental Hematology
David Drexler, Kilian Bertho, Patrick Walkoviak, Clément Derkenne, Hugues Lefort
No abstract text is available yet for this article.
January 2018: Soins; la Revue de Référence Infirmière
Ingrid Lefebvre de Plinval, Justine Josnard, Myriam Honnorat, Hugues Lefort, Romain Kedzierewicz
Frostbites are cold-freezing injuries of the extremities due to the exposure to temperatures below 0°C. The risk, in the absence of treatment, is the amputation of frostbitten areas which become gangrenous. Victims of frostbite must be treated and evacuated urgently. Nurses play an active role in the secondary long-term treatment.
February 2018: Revue de L'infirmière
D Séblain, J Bourlet, R H Khonsari, P Roy, A Gleizal, J Chauvel Picard
OBJECTIVE: Compare literature-reported efficiency and complications of the standard maxillary advancement surgery with those of a minimally invasive mucosal approach in patients with CL/P requiring Le Fort 1 osteotomy. DESIGN: Meta-analysis vs. retrospective analysis of 18 consecutive cases. SETTING: Department of maxillofacial surgery at a tertiary-level public general hospital. PARTICIPANTS: The meta-analysis encompassed Medline, Embase, and Cochrane, years 1990 to 2014, inclusive...
February 2, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
Daniela Garib, Marília Yatabe, Renato André de Souza Faco, Leonardo Gregório, Lucia Cevidanes, Hugo de Clerck
Sagittal maxillary deficiency is frequently observed in patients with operated unilateral complete cleft of the lip and palate. Treatment for moderate to severe Class III malocclusion usually relies on LeFort I surgery for maxillary advancement after the end of growth. This case report describes bone-anchored maxillary protraction in a 10-year-old white boy with unilateral complete cleft of the lip and palate. His interarch relationship was diagnosed as GOSLON index 5 before treatment with a negative overjet of 3...
February 2018: American Journal of Orthodontics and Dentofacial Orthopedics
Abdolreza Jamilian, Rahman Showkatbakhsh, Mohammad Behnaz, Alireza Ghassemi, Zinat Kamalee, Letizia Perillo
BACKGROUND: Distraction osteogenesis (DO) is rapidly becoming a mainstream surgical technique for correction of maxillary deficiency. The aim of this study was to compare the effectiveness of a newly designed tooth-borne osteogenic distraction device with conventional LeFort 1 osteotomy in maxillary advancement of cleft lip and palate patients. METHODS: The DO group consisted of 10 subjects (7 males, 3 females) with a mean age of 21.2 (SD 4.2) years. In these patients, the newly designed distraction device which exerted force anteroposteriorly was cemented after mobilization of the maxilla...
January 31, 2018: Minerva Stomatologica
Sung Chan Kim, Kyunghyun Min, Woo Shik Jeong, Soon Man Kwon, Kyung S Koh, Jong Woo Choi
INTRODUCTION: LeFort III midface advancement using the distraction technique became the standard method for the correction of various craniofacial syndromes accompanied by the midface retrusion. Midface hypoplasia is known to be related to the imbalance in facial aesthetics, malocclusion, and the airway problem. This study aimed to evaluate the change in airway volume after performing a LeFort III midface advancement with the distraction techniques. PATIENTS AND METHODS: Between April 2008 and February 2013, 7 patients aged 5 to 7 years underwent standard LeFort III osteotomy, followed by distraction with a rigid external distractor with or without internal distractor...
January 24, 2018: Annals of Plastic Surgery
Elodie Bosc, Jhennifer Nastri, Valérie Lefort, Fernando Contiguiba da Silva, Renan Pioli, Maysa Furlan, Vanderlan da Silva Bolzani, Chahrazade El Amri, Michèle Reboud-Ravaux
The natural small molecule piperlongumine A is toxic selectively to cancer cells in vitro and in vivo. This toxicity has been correlated with cancer cell ROS, DNA damage and apoptotic cell death increases. We demonstrate here a new mechanistic property of piperlongumine: it inhibits selectively human immunoproteasome with no noticeable inhibition of human constitutive proteasome. This result suggests that immunoproteasome inhibition, a mechanism independent of ROS elevation, may also partly play a role in the anticancer effects observed with piperlongumine...
January 17, 2018: Biochemical and Biophysical Research Communications
Isabelle Moran, Satnam Virdee, Ian Sharp, Jagdeep Sulh
OBJECTIVE: To investigate the postoperative complication rates of LeFort 1 maxillary advancement surgery in cleft patients when performed by a single surgeon over a 5-year period. DESIGN: A retrospective case note review of 79 cleft palate patients. SETTING: All surgery was performed by a single oral and maxillofacial surgeon in a tertiary care center. PARTICIPANTS: All cleft palate patients over 17 years of age who opted for surgical correction of maxillary hypoplasia with a LeFort 1 between 2010 and 2015...
February 2018: Cleft Palate-craniofacial Journal
Benjamin Rossi, Maria Ludovica Gasperini, Véronique Leflon-Guibout, Alice Gioanni, Victoire de Lastours, Geoffrey Rossi, Safi Dokmak, Maxime Ronot, Olivier Roux, Marie-Hélène Nicolas-Chanoine, Bruno Fantin, Agnès Lefort
Liver abscesses containing hypervirulent Klebsiella pneumoniae have emerged during the past 2 decades, originally in Southeast Asia and then worldwide. We hypothesized that hypervirulent K. pneumoniae might also be emerging in France. In a retrospective, monocentric, cohort study, we analyzed characteristics and outcomes for 199 consecutive patients in Paris, France, with liver abscesses during 2010-2015. We focused on 31 patients with abscesses containing K. pneumoniae. This bacterium was present in most (14/27, 52%) cryptogenic liver abscesses...
February 2018: Emerging Infectious Diseases
Marine Coué, Valentin Barquissau, Pauline Morigny, Katie Louche, Corinne Lefort, Aline Mairal, Christian Carpéné, Nathalie Viguerie, Peter Arner, Dominique Langin, Mikael Rydén, Cedric Moro
Robust associations between low plasma level of natriuretic peptides (NP) and increased risk of type 2 diabetes (T2D) have been recently reported in humans. Adipose tissue (AT) is a known target of NP. However it is unknown whether NP signalling in human AT relates to insulin sensitivity and modulates glucose metabolism. We here show in two European cohorts that the NP receptor guanylyl cyclase-A (GC-A) expression in subcutaneous AT was down-regulated as a function of obesity grade while adipose NP clearance receptor (NPRC) was up-regulated...
January 18, 2018: Scientific Reports
Maxime Palazzo, Bertrand Napoléon, Rodica Gincul, Mathieu Pioche, Bertrand Pujol, Christine Lefort, Fabien Fumex, Vincent Hautefeuille, Monique Fabre, Jérome Cros, Michèle Felce, Anne Couvelard, Alain Sauvanet, Philippe Lévy, Philippe Ruszniewski, Laurent Palazzo
BACKGROUND AND AIM: Contrast-harmonic EUS (CH-EUS) has the ability to depict a tumor microvasculature. Decreased microvascular density has been identified as a factor associated with tumor aggressiveness. We aimed to study the accuracy of CH-EUS for the prediction of pancreatic neuroendocrine tumor (PNET) aggressiveness. METHODS: Between June 2009 and March 2015, all consecutive patients with histology-proven PNETs and CH-EUS examination were included. Nine endosonographers analyzed blindly all the videos...
January 8, 2018: Gastrointestinal Endoscopy
Sunil Richardson, Shreya Krishna, Rakshit V Khandeparker
AIM: To describe a comprehensive management protocol to treat cleft maxillary hypoplasia specific to the patient's age, degree of hypoplasia and presence or absence of velopharyngeal incompetence (VPI). MATERIALS AND METHODS: A total of 359 patients suffering from cleft maxillary hypoplasia were retrospectively studied from January 2004 till June 2015. Lateral cephalograms were taken to assess the degree of deformity and advancement achieved at three intervals. Patients were treated by four treatment modalities: Facemask therapy, Anterior maxillary advancement, Total maxillary osteogenesis and LeFort I advancement...
February 2018: Journal of Cranio-maxillo-facial Surgery
Diane S Lazard, Héloïse Bergeret-Cassagne, Muriel Lefort, Laurence Leenhardt, Gilles Russ, Frédérique Frouin, Christophe Trésallet
BACKGROUND: Transcutaneous laryngeal ultrasonography (TLUS) was recently developed to assess recurrent nerve palsy after thyroid/parathyroid surgery, with variable rates of efficiency. The aim of the current study was to evaluate this technique using subjective estimation and post-processing quantitative data. METHODS: Fifty subjects presenting with a recurrent nerve palsy and 50 "controls" presenting with voice, swallowing, or breathing disorders following thyroid/parathyroid surgery were prospectively included...
January 3, 2018: World Journal of Surgery
Guillaume Chassagnon, Bruno Lefort, Mathilde Meot, Elodie Carpentier, Dominique Sirinelli, Alain Chantepie, Baptiste Morel
BACKGROUND: In our practice, we noticed an increased frequency of tracheobronchial branching abnormalities (TBAs) in patients with tetralogy of Fallot (ToF). This study aimed to determine whether an association exists between congenital TBAs and ToF with or without pulmonary atresia. METHODS AND RESULTS: The frequency of TBAs on chest computed tomography was assessed in 55 patients with ToF without pulmonary atresia, 34 patients with ToF with pulmonary arteria, and 100 control patients...
December 29, 2017: Journal of the American Heart Association
Andrey Petrikovets, Theresa Fisher, Christina Krudy, David Sheyn, Jeffrey Mangel, Sangeeta T Mahajan
INTRODUCTION AND HYPOTHESIS: LeFort colpocleisis is a minimally invasive surgical option for patients with pelvic organ prolapse who no longer desire sexual activity. Pelvic surgeons have limited exposure to this procedure during their training, and are therefore less likely to offer this procedure to their patients. METHODS: We use a split screen live action surgery, side by side with a low cost 3D model of a prolapse to describe a LeFort colpocleisis step by step...
December 26, 2017: International Urogynecology Journal
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