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https://www.readbyqxmd.com/read/27918377/utility-of-emergency-department-observation-units-for-neurologically-intact-children-with-head-ct-abnormalities-secondary-to-acute-closed-head-injury
#1
Roxanna Lefort, Jill V Hunter, Andrea T Cruz, A Chantal Caviness, Thomas G Luerssen, Aderonke Adekunle-Ojo
OBJECTIVE: The aim of the study was to evaluate the utility of the emergency department observation unit (EDOU) for neurologically intact children with closed head injuries (CHIs) and computed tomography (CT) abnormalities. METHODS: A retrospective cohort study of children aged 0 to 18 years with acute CHI, abnormal head CT, and a Glasgow Coma Scales score of 14 or higher admitted to the EDOU of a tertiary care children's hospital from 2007 to 2010. Children with multisystem trauma, nonaccidental trauma, and previous neurosurgical or coagulopathic conditions were excluded...
December 1, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27906054/is-radical-surgery-of-an-inverted-papilloma-of-the-maxillary-sinus-obsolete-a-case-report
#2
Vedat Yildirim, Niels Christian Pausch, Dirk Halama, Heinz-Theo Lübbers, Ayhan Yildirim
BACKGROUND: Sinonasal inverted papilloma is a locally aggressive tumor arising from the Schneiderian membrane which lines the nasal cavity and paranasal sinuses. Aggressive surgical approaches, such as lateral rhinotomy, were used until recently for complete removal of the inverted papilloma. Currently, endoscopic resection is the gold standard in the treatment of inverted papilloma. However, there are situations that justify an open approach. For example there are studies that report a higher postoperative recurrence rate after endonasal endoscopic resection, particularly in the treatment of recurrent diseases...
December 1, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27893551/mid-face-degloving-an-alternate-approach-to-extended-osteotomies-of-the-midface
#3
Anantanarayanan Parameswaran, Naveen Kumar Jayakumar, Manikandhan Ramanathan, Hermann F Sailer
Extended osteotomies for mid-face advancement require generous exposure of the anterior maxilla, nasal bones, infraorbital rims, orbital floor, zygoma, and the anterior third of the zygomatic arches. This cannot be obtained with an exclusive transoral approach. Hence, the surgeon is usually compelled to utilize supplemental cutaneous incisions that are a compromise on the purpose behind a cosmetic surgery. In order to alleviate the need for such compromise, the authors advocate the mid face degloving approach for extended osteotomies at Lefort II and Lefort III levels...
November 23, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27852744/integrin-cross-talk-regulates-the-human-neutrophil-response-to-fungal-%C3%AE-glucan-in-the-context-of-the-extracellular-matrix-a-prominent-role-for-vla3-in-the-antifungal-response
#4
Courtney M Johnson, Xian M O'Brien, Angel S Byrd, Valentina E Parisi, Alex J Loosely, Wei Li, Hadley Witt, Hafeez M Faridi, Craig T Lefort, Vineet Gupta, Minsoo Kim, Jonathan S Reichner
Candida albicans infection produces elongated hyphae resistant to phagocytic clearance compelling alternative neutrophil effector mechanisms to destroy these physically large microbial structures. Additionally, all tissue-based neutrophilic responses to fungal infections necessitate contact with the extracellular matrix (ECM). Neutrophils undergo a rapid, ECM-dependent mechanism of homotypic aggregation and NETosis in response to C. albicans mediated by the β2 integrin, complement receptor 3 (CR3, CD11b/CD18, αMβ2)...
November 16, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27833055/le-fort-i-osteotomy-to-enucleation-of-grand-proportions-fissural-cyst-presentation-of-case-report
#5
Rafael Correia Cavalcante, Fernanda Durski, Tatiana Miranda Deliberador, Allan Fernando Giovanini, Nelson Luís Barbosa Rebellato, Delson João da Costa, Leandro Eduardo Klüppel, Rafaela Scariot
Fissural cysts (FC) are caused by entraped epithelium between nasal and maxilar processes. They are commonly treated with surgical enucleation precedded or not by marsupialization depending on the cyst size. Biopsy of lesion is recommended due to confirm radiographic evaluation. It is rare to observe Le Fort I surgical approach to this type of injury. This study reports the case of an uncommon grand proportions fissural cyst in a female patient, 53, that was referred to the Oral and Maxillofacial Surgery Departament of Hospital XV presenting volume increase in maxilla associated with numbness of palate...
November 2, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27817836/transient-right-bundle-branch-block-in-a-patient-with-acute-pulmonary-embolism
#6
Jonathan Gonzva, François-Valéry Viard, Daniel Jost, Hugues Lefort, Jean-Pierre Tourtier
We report the case of an 86-year-old man found at home with acute chest pain and dyspnea. He presented some episodes of left chest pain combined with dyspnea. The physical examination revealed crackling sounds on the bases of the lungs without other anomalies. Electrocardiograms revealed a transient and complete right bundle branch block with inverted T waves in leads V1, V2, and V3. He was diagnosed with a proximal bilateral acute pulmonary embolism without acute cor pulmonale. We describe a case of a transient bundle branch block, without tachycardia or acute cor pulmonale, revealing a pulmonary embolism...
October 21, 2016: Journal of Electrocardiology
https://www.readbyqxmd.com/read/27797357/reprogramming-of-dna-methylation-is-critical-for-nodule-development-in-medicago-truncatula
#7
Carine Satgé, Sandra Moreau, Erika Sallet, Gaëlle Lefort, Marie-Christine Auriac, Céline Remblière, Ludovic Cottret, Karine Gallardo, Céline Noirot, Marie-Françoise Jardinaud, Pascal Gamas
The legume-Rhizobium symbiosis leads to the formation of a new organ, the root nodule, involving coordinated and massive induction of specific genes. Several genes controlling DNA methylation are spatially regulated within the Medicago truncatula nodule, notably the demethylase gene, DEMETER (DME), which is mostly expressed in the differentiation zone. Here, we show that MtDME is essential for nodule development and regulates the expression of 1,425 genes, some of which are critical for plant and bacterial cell differentiation...
October 31, 2016: Nature Plants
https://www.readbyqxmd.com/read/27795260/whole-genome-sequence-of-pseudomonas-graminis-strain-uasws1507-a-potential-biological-control-agent-and-biofertilizer-isolated-in-switzerland
#8
Julien Crovadore, Gautier Calmin, Romain Chablais, Bastien Cochard, Torsten Schulz, François Lefort
We report here the whole-genome shotgun sequence of the strain UASWS1507 of the species Pseudomonas graminis, isolated in Switzerland from an apple tree. This is the first genome registered for this species, which is considered as a potential and valuable resource of biological control agents and biofertilizers for agriculture.
October 6, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27795259/whole-genome-sequence-of-bradyrhizobium-elkanii-strain-uasws1016-a-potential-symbiotic-biofertilizer-for-agriculture
#9
Julien Crovadore, Gautier Calmin, Romain Chablais, Bastien Cochard, Torsten Schulz, François Lefort
Bradyrhizobium elkanii UASWS1016 has been isolated from a wet oxidation sewage plant in Italy. Fully equipped for ammonia assimilation, heavy metal resistances, and aromatic compounds degradation, it carries a large type IV secretion system, specific of plant-associated microbes. Deprived of toxins, it could be considered for agricultural and environmental uses.
October 6, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27793995/identifying-patients-at-risk-for-pre-hospital-sudden-cardiac-arrest-at-the-early-phase-of-myocardial-infarction-the-e-must-study
#10
Nicole Karam, Sophie Bataille, Eloi Marijon, Olivier Giovanetti, Muriel Tafflet, Dominique Savary, Hakim Benamer, Christophe Caussin, Philippe Garot, Jean-Michel Juliard, Virginie Pires, Thévy Boche, François Dupas, Gaelle Lebail, Lionel Lamhaut, François-Xavier Laborne, Hugues Lefort, Mireille B Mapouata, Frédéric Lapostolle, Christian Spaulding, Jean-Philippe Empana, Xavier Jouven, Yves Lambert
BACKGROUND: -In-hospital mortality of ST-Segment Elevation Myocardial Infarction (STEMI) has decreased drastically. In contrast pre-hospital mortality by Sudden Cardiac Arrest (SCA) remains high and difficult to reduce. Identification of the STEMI patients at higher risk for pre-hospital SCA could facilitate rapid triage and intervention in the field. METHODS: - Using a prospective population-based study evaluating all STEMI patients managed by Emergency Medical Services (EMS) in the Greater Paris Area (11...
October 28, 2016: Circulation
https://www.readbyqxmd.com/read/27768771/silencing-of-asc-in-cutaneous-squamous-cell-carcinoma
#11
Katharina Meier, Stefan K Drexler, Franziska C Eberle, Karine Lefort, Amir S Yazdi
Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is an important adaptor protein for inflammasome activation, mediating the secretion of protumorigenic innate cytokines. However, ASC is also known to trigger apoptosis in tumor cells, acting as a tumor-suppressor gene, which is lost in several human cancers. The aim of this study was to evaluate the clinical significance of ASC in human cutaneous squamous cell carcinoma (SCC). Initially, ASC expression was immunohistochemically evaluated in non-metastic and metastatic SCC...
2016: PloS One
https://www.readbyqxmd.com/read/27755425/jaw-in-a-day-state-of-the-art-in-maxillary-reconstruction
#12
Christopher M Runyan, Vishal Sharma, David A Staffenberg, Jamie P Levine, Lawrence E Brecht, Leonard H Wexler, David L Hirsch
BACKGROUND: Reconstruction of maxillary defects following tumor extirpation is challenging because of combined aesthetic and functional roles of the maxilla. One-stage reconstruction combining osseous free flaps with immediate osseointegrated implants are becoming the standard for mandibular defects, and have similar potential for maxillary reconstruction. METHODS: A woman with maxillary Ewing sarcoma successfully treated at age 9 with neoadjuvant chemotherapy, right hemimaxillectomy, and obturator prosthetic reconstruction presented for definitive reconstruction, complaining of poor obturator fit, and hypernasality...
October 14, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27738612/ectopic-ciliated-cyst-in-the-mandible-secondary-to-genioplasty-and-lefort-after-two-years-a-case-report-and-literature-review
#13
Safoura Seifi, Shabnam Sohanian, Oveis Khakbaz, Farida Abesi, Fatemeh Aliakbarpour, Arezoo Rayani
INTRODUCTION: The ectopic ciliated cyst is a rare non-odontogenic cyst which occurs as a delayed complication after maxillary sinus radical surgery; this lesion emerges due to the destruction of the sinus mucosa during the surgery and entrapment of the respiratory epithelium in the region. This lesion has been observed in very rare cases following genioplasty and bimaxillary orthognathic surgery. CASE REPORT: We reported a case of the ectopic ciliated cyst in in the mandible of a 37-year-old Iranian woman following genioplasty and Lefort 1 surgery after 2 years...
September 2016: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/27738050/whole-genome-sequence-of-mesorhizobium-hungaricum-sp-nov-strain-uasws1009-a-potential-resource-for-agricultural-and-environmental-uses
#14
Julien Crovadore, Bastien Cochard, Gautier Calmin, Romain Chablais, Torsten Schulz, François Lefort
We report here the whole-genome shotgun sequences of the strain UASWS1009 of the species Mesorhizobium hungaricum sp. nov., which are different from any other known Mesorhizobium species. This is the first genome registered for this new species, which could be considered as a potential resource for agriculture and environmental uses.
October 13, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27738044/whole-genome-sequence-of-pseudomonas-xanthomarina-strain-uasws0955-a-potential-biological-agent-for-agricultural-and-environmental-uses
#15
Julien Crovadore, Bastien Cochard, Gautier Calmin, Romain Chablais, Torsten Schulz, François Lefort
We report here the whole-genome shotgun sequence of the strain UASWS0955 of the species Pseudomonas xanthomarina, isolated from sewage sludge. This genome was obtained with an Illumina MiniSeq and is the second genome registered for this species, which is considered as a promising resource for agriculture and bioremediation of contaminated soils.
October 13, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27709238/body-composition-and-anti-neoplastic-treatment-in-adult-and-older-subjects-a-systematic-review
#16
S Gérard, D Bréchemier, A Lefort, S Lozano, G Abellan Van Kan, T Filleron, L Mourey, C Bernard-Marty, M E Rougé-Bugat, V Soler, B Vellas, M Cesari, Y Rolland, L Balardy
BACKGROUND: The estimation of the risk of poor tolerance and overdose of antineoplastic agents protocols represents a major challenge in oncology, particularly in older patients. We hypothesize that age-related modifications of body composition (i.e. increased fat mass and decreased lean mass) may significantly affect tolerance to chemotherapy. METHOD: We conducted a systematic review for the last 25 years (between 1990 and 2015), using US National library of Medicine Medline electronic bibliographic database and Embase database of cohorts or clinical trials exploring (i) the interactions of body composition (assessed by Dual X-ray Absorptiometry, Bioelectrical Impedance Analyses, or Computerized Tomography) with pharmacokinetics parameters, (ii) the tolerance to chemotherapy, and (iii) the consequences of chemotherapies or targeted therapies on body composition...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27669438/cxcr4-inhibitors-could-benefit-to-her2-but-not-to-triple-negative-breast-cancer-patients
#17
S Lefort, A Thuleau, Y Kieffer, P Sirven, I Bieche, E Marangoni, A Vincent-Salomon, F Mechta-Grigoriou
The CXCR4 receptor and its ligand CXCL12 (also named stromal cell-derived factor 1, SDF1) have a critical role in chemotaxis and homing, key steps in cancer metastasis. Although myofibroblasts expressing CXCL12 are associated with the presence of axillary metastases in HER2 breast cancers (BC), the therapeutic interest of targeting CXCR4/CXCL12 axis in the different BC subtypes remains unclear. Here, we investigate this question by testing antitumor activity of CXCR4 inhibitors in patient-derived xenografts (PDX), which faithfully reproduce human tumor properties...
September 26, 2016: Oncogene
https://www.readbyqxmd.com/read/27669022/a-cross-modal-genetic-framework-for-the-development-and-plasticity-of-sensory-pathways
#18
Laura Frangeul, Gabrielle Pouchelon, Ludovic Telley, Sandrine Lefort, Christian Luscher, Denis Jabaudon
Modality-specific sensory inputs from individual sense organs are processed in parallel in distinct areas of the neocortex. For each sensory modality, input follows a cortico-thalamo-cortical loop in which a 'first-order' exteroceptive thalamic nucleus sends peripheral input to the primary sensory cortex, which projects back to a 'higher order' thalamic nucleus that targets a secondary sensory cortex. This conserved circuit motif raises the possibility that shared genetic programs exist across sensory modalities...
September 26, 2016: Nature
https://www.readbyqxmd.com/read/27639909/-liver-abscess
#19
G Rossi, E Lafont, L Gasperini, S Dokmak, M Ronot, B Rossi, V Zarrouk, B Fantin, A Lefort
Liver abscess is a rare and severe infection. Incidence increases because of aging of population, advances in liver and biliary surgery including liver transplantation, and immunodeficiency factors. Diagnosis depends mainly on imaging and needle aspiration for microbiological identification. Treatment is based on antibiotics, percutaneous or surgical drainage, and control of the primary source.
September 14, 2016: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/27614813/surgical-correction-without-bone-grafts-of-maxillofacial-asymmetric-deformities-in-patients-treated-for-unilateral-temporomandibular-joint-ankylosis
#20
Yao Liu, Wen Du, Jing Hu, Chuhang Liao, Wei Fei, En Luo
OBJECTIVE: With the inclusion criteria of patients confirmed and the therapeutic effects and stability evaluated, this article presents the clinical value of bimaxillary orthognathic surgery without bone graft of maxillofacial asymmetric deformities in patients treated for unilateral temporomandibular joint (TMJ) ankylosis. STUDY DESIGN: From 2008 to 2012, 12 patients with dentomaxillofacial asymmetric deformities secondary to unilateral TMJ ankylosis who had undergone TMJ reconstruction as the primary surgery were included in the study...
November 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
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