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https://www.readbyqxmd.com/read/28731342/a-formal-synthesis-of-perhydrohistrionicotoxin-using-a-cross-metathesis-hydrogenation-approach
#1
Nicolas Daniel Spiccia, James V Burnley, Kamani Subasinghe, Christopher Perry, Laurent Lefort, W Roy Jackson, Andrea J Robinson
The development of an efficient, high yielding six-step convergent synthesis of the semi-synthetic alkaloid (-)- perhydrohistrionicotoxin is described. The key transformations include the cross metathesis of a Brønsted- acid masked primary homoallylic amine with a vinyl cyclohexenone and a regioselective palladium catalysed hydrogenation. This sequence generated the advanced Winterfeldt spirocyclic precursor in 47% overall yield, with a longest linear sequence of five steps.
July 21, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28729275/whole-genome-sequences-of-14-strains-of-bradyrhizobium-canariense-and-1-strain-of-bradyrhizobium-japonicum-isolated-from-lupinus-spp-in-algeria
#2
Djamel Chekireb, Julien Crovadore, Andreas Brachmann, Romain Chablais, Bastien Cochard, François Lefort
We report here the whole-genome sequences of 14 strains of Bradyrhizobium canariense, isolated from root nodules of Lupinus microanthus and Lupinus angustifolius, and 1 strain of Bradyrhizobium japonicum isolated from root nodules from Lupinus angustifolius in Algeria. These sequences add to the known diversity of this agronomically important genus.
July 20, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28712451/6-10-constituer-une-trousse-de-gestion-des%C3%A2-h%C3%A3-morragies
#3
Christophe Clémence, René Bihannic, Michael Lemaire, Hugues Lefort, Jean-Pierre Tourtier
No abstract text is available yet for this article.
July 2017: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/28705570/la-pose-de-voie-veineuse-p%C3%A3-diatrique-par-les-%C3%A3-quipes-de-smur-adultes
#4
REVIEW
Frédéric Lemoine, Hugues Lefort, Sabine Lemoine, Benoît Frattini, Daniel Jost
Paediatric perfusion during pre-hospital care is a major issue in the event of life-threatening emergencies. Access, often restricted, to backup specialising in paediatrics, implies the existence of practices on protocols for the adult mobile emergency and intensive care service (Smur) in partnership with paediatricians. Paediatric perfusion practices were assessed in these teams. The results show the presence of a paediatric protocol in the adult Smur teams is not very common. Nursing practices seem to be evolving towards the recommendations, thanks to technological advances such as the use of the intraosseous device...
July 2017: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/28700117/infrared-neural-stimulation-induces-intracellular-ca-2-release-mediated-by-phospholipase-c
#5
David Moreau, Claire Lefort, Jolien Pas, Sylvia M Bardet, Philippe Leveque, Rodney P O'Connor
The influence of infrared laser pulses on intracellular Ca(2+) signaling was investigated in neural cell lines with fluorescent live cell imaging. The probe Fluo-4 was used to measure Ca(2+) in HT22 mouse hippocampal neurons and non-electrically excitable U87 human glioblastoma cells exposed to 50-500 ms infrared pulses at 1470 nm. Fluorescence recordings of Fluo-4 demonstrated that infrared stimulation induced an instantaneous intracellular Ca(2+) transient with similar dose-response characteristics in hippocampal neurons and glioblastoma cells (half-maximal effective energy density EC50 of around 58 J...
July 12, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28665842/variations-in-current-procedural-terminology-coding-for-craniofacial-surgery-a-need-for-review-and-change
#6
Ember L Ewings, Petros Konofaos, Robert D Wallace
BACKGROUND: A survey was utilized to study the coding practices of surgeons performing craniofacial procedures, in order to determine whether coding for these procedures might be standardized or expanded. METHODS: An online survey was designed with 6 sample cases to cover a variety of procedures encountered in the field of craniofacial surgery which was sent to members of 3 professional organizations centered around the practice of craniofacial/maxillofacial surgery...
June 29, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28648201/5-10-gestion-d%C3%A2-une-h%C3%A3-morragie-en-situation-de-crise
#7
Frédéric Lemoine, Alexandre Poirot, Isabelle Klein, Hugues Lefort, Jean-Pierre Tourtier
No abstract text is available yet for this article.
June 2017: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/28648187/-role-of-the-nurse-in-the-case-of-complex-hand-wounds
#8
REVIEW
Camille Choufani, Laurent Mathieu, Naklan Ouattara, Hugues Lefort
The initial assessment and care determine the quality of the secondary surgical treatment of complex hand wounds. The caregiver providing this initial care plays a critical role. The analysis of the management of these traumas in exceptional situations enables the key stages of the initial treatment to be identified: bleeding control, infection prevention and an accurate assessment of the injury. These measures thereby help to optimise the patient's transfer towards a specialised unit.
June 2017: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/28643931/clinical-effectiveness-of-late-maxillary-protraction-in-cleft-lip-and-palate-a-methods-paper
#9
M K Lee, C Lane, F Azeredo, M Landsberger, H Kapadia, B Sheller, S L Yen
OBJECTIVES: A prospective parallel cohort trial was conducted to compare outcomes of patients treated with maxillary protraction vs LeFort 1 maxillary advancement surgery. SETTING AND SAMPLE POPULATION: The primary site for the clinical trial is Children's Hospital Los Angeles; the satellite test site is Seattle Children's Hospital. All patients have isolated cleft lip and palate and a skeletal Class III malocclusion. MATERIAL AND METHODS: A total of 50 patients, ages 11-14, will be recruited for the maxillary protraction cohort...
June 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28619798/metagenomes-of-soil-samples-from-an-established-perennial-cropping-system-of-asparagus-treated-with-biostimulants-in-southern-france
#10
Julien Crovadore, Ali Asaff Torres, Raúl Rodríguez Heredia, Bastien Cochard, Romain Chablais, François Lefort
We report here the metagenomes of soil samples from a perennial cropping system of asparagus that was treated with two biostimulants. Two treatments were compared to an untreated control. Control soil samples were taken at the beginning and at end of the experiment.
June 15, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28619630/hilar-fat-infiltration-a-new-prognostic-factor-in-metastatic-clear-cell-renal-cell-carcinoma-with-first-line-sunitinib-treatment
#11
Solène-Florence Kammerer-Jacquet, Angelique Brunot, Karim Bensalah, Boris Campillo-Gimenez, Mathilde Lefort, Sahar Bayat, Alain Ravaud, Frantz Dupuis, Mokrane Yacoub, Gregory Verhoest, Benoit Peyronnet, Romain Mathieu, Alexandra Lespagnol, Jean Mosser, Julien Edeline, Brigitte Laguerre, Jean-Christophe Bernhard, Nathalie Rioux-Leclercq
INTRODUCTION: The selection of patients with metastatic clear cell renal cell carcinoma (ccRCC) who may benefit from targeted tyrosine kinase inhibitors has been a challenge, even more so now with the advent of new therapies. Hilar fat infiltration (HFI) is a validated prognostic factor in nonmetastatic ccRCC (TNM 2009 staging system) but has never been studied in metastatic patients. We aimed to assess its phenotype and prognostic effect in patients with metastatic ccRCC treated with first-line sunitinib...
June 12, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28602449/what-are-the-barriers-and-facilitators-for-the-self-management-of-chronic-pain-with-and-without-neuropathic-characteristics
#12
Elizabeth G Mann, Margaret B Harrison, Sandra LeFort, Elizabeth G VanDenKerkhof
Chronic pain requires affected individuals to self-manage their health. This study compared barriers and facilitators of self-management in two groups of people with chronic pain: those with and without neuropathic characteristics. A cross-sectional survey study of community-dwelling Canadians was conducted. The sample (n = 710) included randomly selected participants who reported chronic pain. The Self-Report Leeds Assessment of Neuropathic Symptoms and Signs was used to screen for neuropathic characteristics...
June 8, 2017: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/28574619/ucp2-upregulation-promotes-plc%C3%AE-1-signaling-during-skin-cell-transformation
#13
Annapoorna Sreedhar, Julia Lefort, Petra Petruska, Xin Gu, Runhua Shi, Sumitra Miriyala, Manikandan Panchatcharam, Yunfeng Zhao
Uncoupling protein 2 (UCP2), whose physiological role is to decrease mitochondrial membrane potential and reactive oxygen species (ROS) production, is often overexpressed in human cancers. UCP2 upregulation has recently been proposed as a novel survival mechanism for cancer cells. However, until now, how exactly UCP2 promotes tumorigenesis remains inconclusive. Based on a widely used skin cell transformation model, our data demonstrated that UCP2 differentially regulated ROS. UCP2 upregulation decreased superoxide whereas it increased hydrogen peroxide production with concomitant increase in the expression and activity of manganese superoxide dismutase (MnSOD), the primary mitochondrial antioxidant enzyme...
June 2, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28572315/deeper-insight-in-beehives-metagenomes-of-royal-jelly-pollen-and-honey-from-lavender-chestnut-and-fir-honeydew-and-epiphytic-and-endophytic-microbiota-of-lavender-and-rose-flowers
#14
Julien Crovadore, François Gérard, Romain Chablais, Bastien Cochard, Karl Kristian Bergman Jensen, François Lefort
Microbiota of beehive products are very little known. We report here for the first time six metagenomes of royal jelly, pollen, and different types of honey from wild and cultivated lavender, chestnut, and fir honeydew. Four metagenomes of epiphytic and endophytic microbiota of lavender and rose flowers are also reported.
June 1, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28550914/self-drilling-and-self-tapping-miniscrews-for-osteosynthesis-fixture-after-lefort-i-osteotomy-an-ex%C3%A2-vivo-trial-for-primary-stability-and-a-randomized-clinical-study
#15
Irina Bolm, Elisabeth Goetze, Peer W Kämmerer, Robert Sader, Michelle Klos, Constantin Landes, Bilal Al-Nawas
BACKGROUND: Self-drilling osteosynthesis screws (SDS) have a potential higher primary stability together with clinical advantages such as less time effort compared to self-tapping screws (STS). The aims of the study were to compare the primary stability of SDS and STS ex vivo and to analyze of the time-saving effect in vivo. MATERIALS AND METHODS: Ex vivo, both screws were placed in porcine bone. Torque was measured for insertion and removal. Four specimens were kept in bone for histologic bone-to-implant-contact examination...
May 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28546481/metagenomes-and-metatranscriptomes-of-activated-sludge-from-a-sewage-plant-with-or-without-aerobic-granule-enrichment
#16
Julien Crovadore, Vice Soljan, Gautier Calmin, Romain Chablais, Bastien Cochard, François Lefort
We report here the metagenomes and metatranscriptomes of activated sludge bioreactors, enriched or not enriched with aerobic granules, at an initial state and after 1 month of incubation. Data showed that the added granular biomass expressed higher levels of expression of genes involved in ammonia elimination.
May 25, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28518042/autochthonous-case-of-eosinophilic-meningitis-caused-by-angiostrongylus-cantonensis-france-2016
#17
Yann Nguyen, Benjamin Rossi, Nicolas Argy, Catherine Baker, Beatrice Nickel, Hanspeter Marti, Virginie Zarrouk, Sandrine Houzé, Bruno Fantin, Agnès Lefort
We report a case of a 54-year-old Moroccan woman living in France diagnosed with eosinophilic meningitis caused by Angiostrongylus cantonensis. Diagnosis was based on clinical symptoms and confirmed by testing of serum and cerebrospinal fluid samples. Physicians should consider the risk for A. cantonensis infection outside of endemic areas.
June 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28483229/use-of-three-dimensional-cad-cam-assisted-virtual-surgical-simulation-and-planning-in-the-pediatric-craniofacial-population
#18
Rachel Gray, Alexander Gougoutas, Vinh Nguyen, Jesse Taylor, Nicholas Bastidas
OBJECTIVE: Virtual Surgical Planning (VSP) and computer-aided design/computer-aided manufacturing (CAD/CAM) have recently helped improve efficiency and accuracy in many different craniofacial surgeries. Research has mainly focused on the use in the adult population with the exception of the use for mandibular distractions and cranial vault remodeling in the pediatric population. This study aims to elucidate the role of VSP and CAD/CAM in complex pediatric craniofacial cases by exploring its use in the correction of midface hypoplasia, orbital dystopia, mandibular reconstruction, and posterior cranial vault expansion...
June 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28473374/metagenome-assembled-genome-sequence-of-rhodopseudomonas-palustris-strain-eli-1980-commercialized-as-a-biostimulant
#19
Julien Crovadore, Shoutao Xu, Romain Chablais, Bastien Cochard, Delvia Lukito, Gautier Calmin, François Lefort
We report here the draft genome sequence of strain ELI 1980 of Rhodopseudomonas palustris, commercialized as a biostimulant for agriculture. The genome was reconstructed from the metagenome of a commercial product containing this strain as its major component.
May 4, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28472384/sms-smart-model-selection-in-phyml
#20
Vincent Lefort, Jean-Emmanuel Longueville, Olivier Gascuel
Model selection using likelihood-based criteria (e.g. AIC) is one of the first steps in phylogenetic analysis. One must select both a substitution matrix and a model for rates across sites. A simple method is to test all combinations and select the best one. We describe heuristics to avoid these extensive calculations. Runtime is divided by ∼2 with results remaining nearly the same, and the method performs well compared to ProtTest and jModelTest2. Our software, "Smart Model Selection" (SMS), is implemented in the PhyML environment and available using two interfaces: command-line (to be integrated in pipelines) and a web server (http://www...
May 2, 2017: Molecular Biology and Evolution
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