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https://www.readbyqxmd.com/read/28060370/diagnosing-the-most-common-odontogenic-cystic-and-osseous-lesions-of-the-jaws-for-the-practicing-pathologist
#1
Robert A Robinson
Odontogenic cysts and osseous lesions are often seen as challenging diagnostic lesions but the majority of them are easily classified. This article outlines the diagnostic features required for separating the most common of odontogenic cysts and select osseous lesions of the jaws. Clinical and radiographic findings of these jaw lesions often lead to a differential diagnosis that only the histologic findings will clarify. Dentigerous cyst, keratocystic odontogenic tumor, and certain ameloblastomas that have cystic change, may have identical radiographic findings, with only separation by their specific histologic features leading to the significantly different treatments required for each...
January 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28054463/kallikrein-related-peptidase-expression-in-odontogenic-cysts-and-tumors-an-immunohistochemical-comparative-study
#2
Mark Roger Darling, Rebecca Woodford, Karl Kevin Cuddy, Linda Jackson-Boeters, Alyssa Hayter, Jeyanth Inkaran, Eleftherios P Diamandis, Zia Khan
AIM: The aim of the present study was to profile the expression of human kallikrein (KLK)-related peptidases (KLK) in odontogenic lesions. METHODS: Paraffin-embedded, formalin-fixed, non-odontogenic (control) and odontogenic lesions were stained for KLK using a standard immunohistochemical technique. The intensity and proportion of epithelial cells stained was scored. Reverse transcription-polymerase chain reaction was utilized to evaluate KLK 1-15 mRNA expression in ameloblastomas...
January 4, 2017: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/28025428/expression-of-p73-and-trail-in-odontogenic-cysts-and-tumors
#3
Marco Mascitti, Andrea Santarelli, Antonio Zizzi, Maurizio Procaccini, Lorenzo Lo Muzio, Corrado Rubini
Odontogenic tumors are a group of lesions arising from the odontogenic apparatus. Although the mechanism of oncogenesis and tumor progression in these lesions remains unknown, certain proteins, such as those involved in apoptosis, seem to be involved in the differentiation and proliferation of odontogenic epithelial cells. The aim of this study was to analyze the expression of p73 and TNF-related apoptosis-inducing ligand (TRAIL) in odontogenic tumors and cysts, and to clarify changes in the expression of these proteins...
2016: Journal of Oral Science
https://www.readbyqxmd.com/read/28011178/recurrence-probability-for-keratocystic-odontogenic-tumors-an-analysis-of-6427-cases
#4
Bruno Ramos Chrcanovic, Ricardo Santiago Gomez
PURPOSE: To investigate and compare the probability of recurrence of keratocystic odontogenic tumors (KCOTs) for different variables and treatment protocols. MATERIALS AND METHODS: An electronic search was undertaken in April 2016 that included clinical series of KCOTs reporting recurrences. Untransformed proportions and meta-analyses were performed to estimate the probability/risk of recurrence, according to several variables. RESULTS: A total of 94 publications were included (6427 KCOTs, 1464 recurrences)...
November 19, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27992735/morphological-classification-of-odontogenic-keratocysts-using-bouligand-minkowski-fractal-descriptors
#5
Joao B Florindo, Odemir M Bruno, Gabriel Landini
The Odontogenic keratocyst (OKC) is a cystic lesion of the jaws, which has high growth and recurrence rates compared to other cysts of the jaws (for instance, radicular cyst, which is the most common jaw cyst type). For this reason OKCs are considered by some to be benign neoplasms. There exist two sub-types of OKCs (sporadic and syndromic) and the ability to discriminate between these sub-types, as well as other jaw cysts, is an important task in terms of disease diagnosis and prognosis. With the development of digital pathology, computational algorithms have become central to addressing this type of problem...
December 8, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/27957281/malignant-changes-developing-from-odontogenic-cysts-a-systematic-review
#6
REVIEW
Jordi Borrás-Ferreres, Alba Sánchez-Torres, Cosme Gay-Escoda
The aim of this study was to systematically review scientific literature in orderto describe the characteristics and prognosis of malignant entities developing from odontogenic cysts. A search in Pubmed (MEDLINE) and Cochrane databases was conducted. The inclusion criteria were articles published in English related to the malignisation of odontogenic cysts in humans. The exclusion criteria were articles that do not specify the type of odontogenic cyst, malignisation of parakeratinised keratocysts, the presence of an ameloblastic carcinoma and metastasis from distant primary tumours...
December 2016: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/27957261/p53-p63-and-p73-expression-and-angiogenesis-in-keratocystic-odontogenic-tumors
#7
Soranun Chandrangsu, Kraisorn Sappayatosok
BACKGROUND: Keratocystic odontogenic tumors (KCOTSs) are odontogenic tumors previously referred to as odontogenic keratocysts. Several studies have reported that KCOT behavior is more like that of a benign neoplasm than a cyst. KCOTs are locally destructive and exhibit a high recurrence rate. The objective of this study is to characterize the expression of p53, p63 and p73 in KCOTs together with the relationship between their expression and KCOT angiogenesis and recurrence. MATERIAL AND METHODS: Standard indirect immunohistochemistry using monoclonal antibodies specific to human p53, p63, p73 and CD105 was performed in formalin-fixed paraffin-embedded tissue sections of 39 KCOT samples...
December 2016: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/27955959/what-surgical-treatment-has-the-lowest-recurrence-rate-following-the-management-of-keratocystic-odontogenic-tumor-a-large-systematic-review-and-meta-analysis
#8
Essam Ahmed Al-Moraissi, Ayed Ali Dahan, Mohamed Salah Alwadeai, Fadekemi Olufunmilayo Oginni, Jamil Mohammed Al-Jamali, Ahmed Saleh Alkhutari, Nashwan Hamid Al-Tairi, Abdulrazaq Ahmed Almaweri, Jaber Saleh Al-Sanabani
PURPOSE: Among the different surgical treatments for keratocystic odontogenic tumors (KOTs), there is no single method associated with a zero recurrence rate (RR). Thus, this study aimed to seek the best surgical treatment with the least RR using a weighted event rated meta-analysis. MATERIALS AND METHODS: To address our study purpose, a systematic review and meta-analysis based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guideline was performed...
January 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27935113/fak-is-overexpressed-in-keratocystic-odontogenic-tumor-a-preliminary-study
#9
Sachin C Sarode, Gargi S Sarode, Shakira Choudhary, Shankargouda Patil
BACKGROUND: Focal adhesion kinase (FAK) is an important mediator of cell adhesion, growth proliferation, survival, angiogenesis, and migration. FAK is over expressed in many locally invasive and malignant lesions including oral cancer. Looking at the tumorigenic nature of keratocystic odontogenic tumor (KCOT), which involves local invasion, proliferation, and recurrence, we hypothesized strong expression of FAK in the epithelial lining of KCOT. MATERIALS AND METHODS: 34 KCOTs, 11 orthokeratinized odontogenic cysts (OOCs), 25 radicular cysts (RCs), 17 dentigerous cysts (DCs) and 25 dental follicles (DFs) were retrieved from archives and subjected to the immunohistochemical analysis using FAK antibody...
December 9, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27873145/use-of-refrigerant-spray-of-a-propane-butane-isobutane-gas-mixture-in-the-management-of-keratocystic-odontogenic-tumors-a-preliminary-study
#10
Eduardo Luis de Souza Cruz, Ana Karla da Silva Tabosa, Aline Semblano Carreira Falcão, Talita Tartari, Lucas Machado de Menezes, Edmar Tavares da Costa, José Thiers Carneiro Júnior
PURPOSE: Keratocystic odontogenic tumor (KCOT) is an aggressive benign tumor and the management by complete enucleation followed by cryotherapy maintains the inorganic bone matrix, resulting in better repair and reduces the rates of recurrence. A refrigerant spray with a propane/butane/isobutane gas mixture has been pointed to as an alternative to liquid nitrogen, because the device is easy to handle and contain within the cavity, providing better control and lower risk of injury to the adjacent soft tissue...
November 21, 2016: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27857903/orthokeratinized-odontogenic-cyst-masquerading-as-dentigerous-cyst
#11
Devi Charan Shetty, Ajit Singh Rathore, Anshi Jain, Natasha Thokchom, Neha Khurana
The orthokeratinized odontogenic cyst (OOC) is a rare developmental odontogenic cyst that has been considered as a variant of the keratocystic odontogenic tumor until Wright (1981) defined it as a different entity. Recognition of OOC as a unique entity has long been due, yet its inexplicable clinical, radiographic presentation resembling dentigerous cyst due to its association to an impacted tooth, and its histological features makes it rather perplexing. This is the report of a case of OOC in relation to an impacted maxillary canine and its immunohistochemical analysis with Ki-67...
October 2016: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/27857042/odontogenic-keratocysts-in-the-basal-cell-nevus-gorlin-goltz-syndrome-associated-with-paresthesia-of-the-lower-jaw-case-report-retrospective-analysis-of-a-representative-czech-cohort-and-recommendations-for-the-early-diagnosis
#12
Milan Hubacek, Tereza Kripnerova, Michaela Nemcikova, Anna Krepelová, Alena Puchmajerova, Marcela Malikova, Markéta Havlovicová, Jana Cadova, Roman Kodet, Milan Macek, Tatjana Dostalova
OBJECTIVES: Identification of early presenting signs of the Basal Cell Nevus (BCNS; synonyme Gorlin-Goltz) syndrome, which is associated with a principal triad of multiple basal cell nevi, jaw odontogenic keratocysts, and skeletal anomalies, in stomatological and neurological practices. Proposal of multidisciplinary diagnostic algorithm comprising other medical specialists, including pathology, imaging, laboratory and molecular analyses based on the study outcomes. DESIGN: Case report of a male patient reporting paresthesia of their lower jaw, with right facial asymmetry (maxilla and mandible) and radiological detection of large osteolytic lesions in both jaws, including a retrospective analysis of a representative Czech cohort with BCNS from within the last decade...
September 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/27853924/retrospective-analysis-of-nonendodontic-periapical-lesions-misdiagnosed-as-endodontic-apical-periodontitis-lesions-in-a-population-of-taiwanese-patients
#13
Hsun-Yu Huang, Yuk-Kwan Chen, Edward Cheng-Chuan Ko, Fu-Hsiung Chuang, Ping-Ho Chen, Ching-Yi Chen, Wen-Chen Wang
OBJECTIVE: We aimed to evaluate nonendodontic periapical lesions clinically misdiagnosed as endodontic periapical pathoses in a population of Taiwanese patients. MATERIALS AND METHODS: Cases (2000-2014) of histopathological diagnoses of nonendodontic periapical lesions were retrieved from all cases with a clinical diagnosis of radicular cyst, apical granuloma, or apical periodontitis in the institution. These cases were regarded as misdiagnosed nonendodontic periapical lesions, of which the types and frequencies, in addition to the demographic data, were determined...
November 16, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27847737/treatment-of-nevoid-basal-cell-carcinoma-syndrome-a-case-report
#14
Dong-Uk Seo, Su-Gwan Kim, Ji-Su Oh, Jae-Seek You
Nevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin syndrome, is characterized by various embryological deformities and carcinoma formation. It is caused by PTCHI gene mutations and is autosomal dominantly inherited. Some of the main symptoms of NBCCS are multiple basal cell carcinomas, multiple keratocystic odontogenic tumors (KCOTs) of the mandible, hyperkeratosis of the palmar and plantar, skeletal deformity, calcification of the falx cerebri, and facial defomity. Recurrent KCOT is the main symptom of NBCCS and is present in approximately 90% of patients...
October 2016: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/27843260/gorlin-goltz-syndrome-a-rare-case-report-of-a-11-year-old-child
#15
Sandeep Tandon, Yashwant Chauhan, Meenakshi Sharma, Manish Jain
: Gorlin-Goltz Syndrome, also known as nevoid basal cell carcinoma syndrome (NBCCS), is an autosomal dominant trait caused due to mutations in the patched tumor suppressor gene (PTCH) gene found on the long arm of chromosome 9. The syndrome is characterized by the presence of odontogenic keratocysts (OKCs), basal cell carcinomas, and skeletal malformations. Early diagnosis of the syndrome can be done by pedodontist as OKC is one of the early manifestations of the syndrome. Early diagnosis and treatment is important for long-term prognosis of the syndrome by reducing the severity of cutaneous carcinomas and deformities due to jaw cyst...
July 2016: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/27833347/treatment-of-keratocystic-odontogenic-tumours-a-prospective-study-of-30-cases
#16
Ashish Gupta, Pankaj Bansal, Rahul Sharma, Sneha D Sharma
AIM: This prospective study aimed at presenting different treatment modalities and its association with the recurrence rate of KCOT. MATERIAL AND METHOD: The study was conducted on 30 patients diagnosed with KCOT between March 2009 and 2012. The patients were followed up for a period of at least 1 year. The clinical, radiographic and demographic data were recorded and four different treatment modalities were followed to assess the recurrence of the tumour. RESULTS: In the study, KCOT showed male predominance with a male: female ratio of 23:7...
December 2016: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/27818958/giant-keratocystic-odontogenic-tumor-a-challenging-diagnosis
#17
Rachna Kaushik, Kumar Pushpanshu, Silky Rajesh Punyani, Vineet Raj
The keratocystic odontogenic tumor, although a benign lesion, is peculiarly aggressive with a high recurrence rate. Its involvement with the maxillary antrum is atypical. We report the unusual case of a 20-year-old male patient with an extensive antral tumor associated with an impacted third molar, which was initially misdiagnosed as a dentigerous cyst. Clinical, radiographic, and histopathologic aspects were analyzed to provide useful information for the correct diagnosis, treatment, and prognosis within a multidisciplinary approach...
July 2016: Autopsy & case reports
https://www.readbyqxmd.com/read/27789270/topical-5-fluorouracil-is-a-novel-targeted-therapy-for-the-keratocystic-odontogenic-tumor
#18
Nicholas J Ledderhof, Marco F Caminiti, Grace Bradley, David K Lam
PURPOSE: The antimetabolite drug, 5-fluorouracil (5-FU), is used in the treatment of various cancers, including basal cell carcinomas (BCCs). The authors hypothesized that keratocystic odontogenic tumors (KOTs) would respond to 5-FU treatment because of their similarities to BCCs in molecular etiopathogenesis. MATERIALS AND METHODS: An ambispective cohort study of the treatment efficacy of topical 5-FU on KOTs was conducted. Independent variables included the topical application of 5% 5-FU or modified Carnoy solution (MC) after enucleation and peripheral ostectomy at the University of Toronto from 2006 through 2014...
September 30, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27747382/clinicopathological-and-cell-proliferation-evaluation-of-ameloblastomas-and-keratocystic-odontogenic-tumors-a-10%C3%A2-year-retrospective-study
#19
Leorik Pereira da Silva, Marianna Sampaio Serpa, Thalita Santana, George João Ferreira do Nascimento, Emanuel Sávio de Souza Andrade, Ana Paula Veras Sobral
Odontogenic tumors (OTs) are important lesions of the gnathic bones due to their clinicopathological heterogeneity and variable biological behavior; therefore, epidemiological studies are needed to outline the incidence and behavior of these tumors. To evaluate the incidence and epidemiological profile of ameloblastoma (AMB) and keratocystic odontogenic tumor (KCOT) from an oral pathology service, and correlate morphological findings of these tumors with the immunoexpression of a cellular proliferation marker (Ki-67), a retrospective study (2002-2012) was conducted to characterize demographic, clinical, radiological, and morphological data of AMBs and KCOTs...
October 17, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27723645/keratocystic-odontogenic-tumor-with-ossification-and-calcification-a-case-report-with-unusual-histological-findings
#20
Swati Shrikant Gotmare, Avinash Tamgadge, Treville Pereira, Anusha Shetty
The keratocystic odontogenic tumor (KCOT), formerly known as odontogenic keratocyst, is a benign developmental odontogenic tumor with many distinguishing clinical and histologic features. Hard tissue deposits, which usually take the form of dystrophic calcifications, cartilaginous tissue, or dentinoid, are uncommon findings in the connective tissue capsule of the KCOT. We report a case of a 33-year-old female with KCOT showing osseous tissue and calcified deposits close to its epithelial lining, which is an extremely rare occurrence...
July 2016: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
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