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Cynthia Gyamfi-Bannerman

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https://www.readbyqxmd.com/read/27729253/association-between-change-in-cervical-length-and-spontaneous-preterm-birth-in-twin-pregnancies
#1
Leslie A Moroz, Clifton O Brock, Shravya Govindappagari, Denise L Johnson, Elizabeth H Leopold, Cynthia Gyamfi-Bannerman
BACKGROUND: There is a lack of consensus on the optimal transvaginal cervical length (TVCL) for determining risk for spontaneous preterm (SPTB) in twin pregnancies. Change in TVCL over time may reflect early activation of the parturition process, as has been demonstrated in singleton pregnancies. The association between change in TVCL and the risk for SPTB has not yet been described in the population of women with diamniotic twin pregnancies. OBJECTIVES: Our primary objective is to determine whether rate of change in TVCL in the midtrimester is associated with SPTB in twin gestations...
October 8, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27500933/comparison-of-respiratory-outcomes-between-preterm-small-for-gestational-age-and-appropriate-for-gestational-age-infants
#2
Amy L Turitz, Cynthia Gyamfi-Bannerman
Objective This study aims to determine whether preterm infants who are small for gestational age (SGA) are more likely to have respiratory distress syndrome (RDS) compared with appropriate-for-gestational-age infants. Methods Secondary analysis of a multicenter trial evaluating magnesium for neuroprotection. Nonanomalous, singleton gestations delivered between 22 (0/7) and 36 (6/7) weeks were included. Large-for-gestational-age infants were excluded. We performed a nested case-control study. Cases were infants with RDS; controls were infants without RDS...
August 8, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27262971/a-prediction-model-of-vaginal-birth-after-cesarean-in-the-preterm-period
#3
Anne H Mardy, Cande V Ananth, William A Grobman, Cynthia Gyamfi-Bannerman
BACKGROUND: A validated model exists that predicts the probability of vaginal birth after cesarean delivery in patients at term who are undergoing a trial of labor after cesarean delivery. However, a model that predicts the success of a vaginal birth after cesarean delivery in the preterm period has not been developed. OBJECTIVE: We sought to develop and validate a predictive model for vaginal birth after cesarean delivery for women undergoing a trial of labor after cesarean delivery during the preterm period...
October 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27177525/proximity-of-magnesium-exposure-to-delivery-and%C3%A2-neonatal%C3%A2-outcomes
#4
Amy L Turitz, Gloria T Too, Cynthia Gyamfi-Bannerman
BACKGROUND: In infants delivered preterm, magnesium sulfate reduces cerebral palsy in survivors. The benefit of magnesium given remote from delivery is unclear. OBJECTIVE: Our objective was to evaluate the association of time from last exposure to magnesium with cerebral palsy. STUDY DESIGN: This was a secondary analysis of a multicenter trial evaluating magnesium for neuroprotection. For this study, we included women with live, nonanomalous, singleton gestations who received magnesium...
October 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27126296/what-we-have-learned-about-antenatal-corticosteroid-regimens
#5
REVIEW
Ronald J Wapner, Cynthia Gyamfi-Bannerman, Elizabeth A Thom
Administration of antenatal corticosteroids has been standard of care for women between 24 and 34 weeks of gestation who are at risk for preterm delivery for more than 20 years longer in other parts of the world. Although the benefit of steroids in this population has been confirmed, there remain many questions including the frequency of dosing and whether it is possible to expand the gestational age criteria to women likely to deliver before 24 weeks or after 34 weeks. The MFMU Network has played a major role in answering some of these questions...
August 2016: Seminars in Perinatology
https://www.readbyqxmd.com/read/26953657/prenatal-and-perinatal-determinants-of-lung-health-and-disease-in-early-life-a-national-heart-lung-and-blood-institute-workshop-report
#6
Tracy A Manuck, Philip T Levy, Cynthia Gyamfi-Bannerman, Alan H Jobe, Carol J Blaisdell
Human lung growth and development begins with preconception exposures and continues through conception and childhood into early adulthood. Numerous environmental exposures (both positive and negative) can affect lung health and disease throughout life. Infant lung health correlates with adult lung function, but significant knowledge gaps exist regarding the influence of preconception, perinatal, and postnatal exposures on general lung health throughout life. On October 1 and 2, 2015, the National Heart, Lung, and Blood Institute convened a group of extramural investigators to develop their recommendations for the direction(s) for future research in prenatal and perinatal determinants of lung health and disease in early life and to identify opportunities for scientific advancement...
May 2, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/26936188/maternal-microbiome-a-pathway-to-preterm-birth
#7
REVIEW
Angela E Vinturache, Cynthia Gyamfi-Bannerman, Joseph Hwang, Indira U Mysorekar, Bo Jacobsson
Despite great medical advances in preventing maternal and infant mortality in the past century, one issue remains unresolved: why do so many women give birth prematurely? A major new field of human microbiome studies has begun to shed light on the impact of microbes (of both the commensal and pathogen varieties) on pregnancy outcomes. Recent advances in next-generation sequencing and metagenomic analysis have revealed that maternal microbiomes at a variety of niches including the oral, vaginal, gut, cervical, and even the placenta itself govern pregnancy outcomes...
April 2016: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26930156/late-preterm-neonatal-morbidity-in-hypertensive-versus-normotensive-women
#8
Victoria M Fratto, Cande V Ananth, Cynthia Gyamfi-Bannerman
OBJECTIVE: We estimated risks of late preterm (LP, 34°(/7)-36(6/7) weeks) delivery and neonatal respiratory and non-respiratory morbidity in women with mild and severe hypertension, in both low-risk and high-risk (history of chronic hypertension, preeclampsia (PE), or insulin-dependent diabetes in current pregnancy) cohorts. STUDY DESIGN: This is a secondary analysis of two Maternal-Fetal Medicine Units Network randomized trials of aspirin to prevent PE. Women with non-anomalous singleton gestations delivered at ≥34 weeks were divided into three groups: normotensive, mild PE/gestational hypertension (GH), and severe PE/GH...
May 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/26924744/a-comparison-of-prevaginal-and-postvaginal-manipulation-fetal-fibronectin
#9
Amy L Turitz, Christina M Ackerman, Denise L Johnson, Tracy C Bank, Jimmy K Duong, Shing M Lee, Cynthia Gyamfi-Bannerman
BACKGROUND: Fetal fibronectin (fFN) is used as a biomarker for preterm delivery. Currently, its use is discouraged if there has been vaginal manipulation in the previous 24 hours. OBJECTIVE: Our objective is to determine if there are differences between fFN results before and after vaginal manipulation in the form of sterile vaginal exam or transvaginal ultrasound. STUDY DESIGN: This was a prospective observational cohort study at a single center of women between 22-33 6/7 weeks at risk for preterm delivery due to: (1) a history of preterm delivery, short cervix, or multifetal gestation; or (2) symptoms of preterm labor...
May 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26906337/prediction-and-prevention-of-preterm-birth-and-its-sequelae
#10
EDITORIAL
Kim Boggess, Cynthia Gyamfi-Bannerman
No abstract text is available yet for this article.
April 2016: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26902990/diagnosis-and-antenatal-management-of-congenital-cytomegalovirus-infection
#11
Brenna L Hughes, Cynthia Gyamfi-Bannerman
Congenital cytomegalovirus (CMV) is the most common viral infection, affecting nearly 40,000 infants each year in the United States. Of seronegative women, 1-4% will acquire a primary infection during pregnancy, and the majority of these women will be asymptomatic. Prior maternal exposure to CMV does not preclude neonatal infection. The purpose of this document is to review diagnosis of primary maternal CMV infection, diagnosis of fetal CMV infection, and whether antenatal therapy is warranted. We recommend the following: (1) that women with a diagnosis of primary CMV infection in pregnancy be advised that the risk of congenital infection is 30-50%, on average, and that the severity of infection varies widely (Best Practice); (2) for women suspected of having primary CMV infection in pregnancy, we recommend that diagnosis should be either by IgG seroconversion or with positive CMV IgM, positive IgG, and low IgG avidity (grade 1B); (3) amniocentesis is the best option as a prenatal diagnostic tool to detect fetal congenital CMV infection, performed >21 weeks of gestation and >6 weeks from maternal infection (grade 1C); (4) we do not recommend routine screening of all pregnant women for evidence of primary CMV infection at this time (grade 1B); and (5) we do not recommend antenatal treatment with ganciclovir or valacyclovir; and we recommend that any antenatal therapy, either with antivirals or CMV hyperimmune globulin, should only be offered as part of a research protocol (Best Practice)...
June 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26855093/chorioamnionitis-and-neurocognitive-development-at-age-2-years
#12
Emilie Vander Haar, Cynthia Gyamfi-Bannerman
OBJECTIVE: To evaluate whether chorioamnionitis is associated with decreased Bayley II scores at age 2 years. METHODS: We conducted an observational cohort study of women and their offspring enrolled in the Eunice Kennedy Shriver National Institute of Child Health and Development's Maternal-Fetal Medicine Units Network multicenter, randomized controlled trial of magnesium for cerebral palsy prevention in pregnancies at high risk for early preterm delivery. We included nonanomalous singleton gestations and excluded pregnancies missing outcome or exposure data...
March 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26842679/antenatal-betamethasone-for-women-at-risk-for-late-preterm-delivery
#13
RANDOMIZED CONTROLLED TRIAL
Cynthia Gyamfi-Bannerman, Elizabeth A Thom, Sean C Blackwell, Alan T N Tita, Uma M Reddy, George R Saade, Dwight J Rouse, David S McKenna, Erin A S Clark, John M Thorp, Edward K Chien, Alan M Peaceman, Ronald S Gibbs, Geeta K Swamy, Mary E Norton, Brian M Casey, Steve N Caritis, Jorge E Tolosa, Yoram Sorokin, J Peter VanDorsten, Lucky Jain
BACKGROUND: Infants who are born at 34 to 36 weeks of gestation (late preterm) are at greater risk for adverse respiratory and other outcomes than those born at 37 weeks of gestation or later. It is not known whether betamethasone administered to women at risk for late preterm delivery decreases the risks of neonatal morbidities. METHODS: We conducted a multicenter, randomized trial involving women with a singleton pregnancy at 34 weeks 0 days to 36 weeks 5 days of gestation who were at high risk for delivery during the late preterm period (up to 36 weeks 6 days)...
April 7, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/26640166/future-directions-in-preterm-birth-research
#14
REVIEW
Joses Jain, Cynthia Gyamfi-Bannerman
The problem of preterm birth continues to pose one of the most significant research challenges that we face due to its immense scope and complexity. With evidence that 95% of cases of spontaneous preterm birth are intractable to current interventions, our best hope in resolving this problem may lie in new, innovative ideas. Novel approaches to researching preterm birth are currently underway, building upon our prior discoveries and probing into the unknown on multiple fronts. Here we discuss some of the major focuses of future investigation that provide a promising outlook for discovery, including advanced techniques to evaluate the cervix, new strategies to identify the role of the microbiome, and advances in molecular and epigenetic-based research...
April 2016: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26595801/prolonged-latency-of-preterm-premature-rupture-of-membranes-and-risk-of-cerebral-palsy
#15
Daphnie Drassinower, Alexander M Friedman, Sarah G Običan, Heather Levin, Cynthia Gyamfi-Bannerman
OBJECTIVE: To determine whether prolonged latency after preterm premature rupture of membranes (PPROM) is associated with an increased risk of death or moderate-to-severe cerebral palsy (CP). STUDY DESIGN: This secondary analysis of the randomized controlled trial of magnesium sulfate for the prevention of CP evaluated whether the time interval between diagnosis of PPROM and delivery was associated with increased risk for CP. Prolonged latency was defined as an interval of ≥4 weeks, latency time was also categorized by week of latency for further analysis...
September 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26512741/trial-of-labor-after-cesarean-versus-repeat-cesarean-in-women-with-small-for-gestational-age-neonates-a-secondary-analysis
#16
Amy L Turitz, Alexander M Friedman, Cynthia Gyamfi-Bannerman
OBJECTIVE: The objective of this study was to determine whether trial of labor after cesarean (TOLAC) is associated with increased risk of adverse outcomes for small-for-gestational-age (SGA) neonates. METHODS: This secondary analysis of a multicenter prospective observational study evaluated SGA neonates born to women with a single prior cesarean delivery. Nonanomalous, singleton pregnancies delivered at 24-41 weeks were included. The primary exposure was whether women underwent planned cesarean versus attempted TOLAC...
September 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26215326/does-the-clinical-presentation-of-a-prior-preterm-birth-predict-risk-in-a-subsequent-pregnancy
#17
Daphnie Drassinower, Sarah G Običan, Zainab Siddiq, Danielle Heller, Cynthia Gyamfi-Bannerman, Alexander M Friedman
OBJECTIVE: The objective of the study was to determine whether risk of recurrent preterm birth differs based on the clinical presentation of a prior spontaneous preterm birth (SPTB): advanced cervical dilatation (ACD), preterm premature rupture of membranes (PPROM), or preterm labor (PTL). STUDY DESIGN: This retrospective cohort study included singleton pregnancies from 2009 to 2014 complicated by a history of prior SPTB. Women were categorized based on the clinical presentation of their prior preterm delivery as having ACD, PPROM, or PTL...
November 2015: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26144412/surgical-speed-and-risk-for-maternal-operative-morbidity-in-emergent-repeat-cesarean-delivery
#18
MULTICENTER STUDY
Leslie Moroz, Marianne DiNapoli, Mary D'Alton, Cynthia Gyamfi-Bannerman
OBJECTIVE: The purpose of this study was to determine whether surgical speed is associated with maternal outcomes in women who have a history of previous cesarean delivery (CD) and who require emergent delivery. STUDY DESIGN: This is a secondary analysis of a multicenter, prospective observational study of women with a history of previous CD. Women who attempted a vaginal birth after CD and required emergent CD were dichotomized into those with a skin incision-to-fetal delivery time of ≤2 min (I-D ≤2) or >2 min (I-D >2), based on the mode I-D...
October 2015: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26116869/mode-of-delivery-at-periviability-and-early-childhood-neurodevelopment
#19
Sarah G Običan, Alyson Small, Devin Smith, Heather Levin, Daphnie Drassinower, Cynthia Gyamfi-Bannerman
OBJECTIVE: Little is known regarding the impact of mode of delivery in the periviable period. Even less is understood regarding the effect of mode of delivery on neurodevelopment. Our objective is to determine if the mode of delivery at time of periviability impacts Bayley II scores at 2 years of age. STUDY DESIGN: This is a secondary analysis of a randomized, controlled trial of magnesium sulfate for the prevention of cerebral palsy, a multicenter trial where women at imminent risk for delivery were assigned to receive magnesium sulfate or placebo...
October 2015: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26026919/does-magnesium-exposure-affect-neonatal-resuscitation
#20
RANDOMIZED CONTROLLED TRIAL
Daphnie Drassinower, Alexander M Friedman, Heather Levin, Sarah G Običan, Cynthia Gyamfi-Bannerman
OBJECTIVE: Research on immediate neonatal resuscitation suggests that maternal magnesium exposure may be associated with increased risk of low Apgar scores, hypotonia, and neonatal intensive care unit admission. However, not all studies support these associations. Our objective was to determine whether exposure to magnesium at the time of delivery affects initial neonatal resuscitation. STUDY DESIGN: This is a secondary analysis of the Randomized Controlled Trial of Magnesium Sulfate for the Prevention of Cerebral Palsy that evaluated whether the study drug (magnesium or placebo) that was administered at the time of delivery was associated with increased risk for a composite adverse neonatal resuscitation outcome (5-minute Apgar score <7, oxygen administration in the delivery room, intubation, chest compressions, hypotension, and hypotonicity)...
September 2015: American Journal of Obstetrics and Gynecology
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