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Uma Reddy

Battini Mohan Reddy, Uma Jyothi Kommoju, Shilpi Dasgupta, Pranavchand Rayabarapu
BACKGROUND & OBJECTIVES: Polycystic ovary syndrome (PCOS) is the most common reproductive endocrine disorder of premenopausal women. Given the phenotypic overlap between PCOS and type 2 diabetes mellitus (T2DM), this study was carried out to investigate whether genes implicated in T2DM were also involved in the susceptibility to PCOS among women from southern India. METHODS: A total of 248 women with PCOS and 210 healthy women as controls were genotyped for a panel of 15 single nucleotide polymorphisms (SNPs) from the nine T2DM genes, such as TCF7L2, IGF2BP2, SLC30A8, HHEX, CDKAL1, CDKN2A, IRS1, CAPN10 and PPARG, on Sequenom MassARRAY platform...
September 2016: Indian Journal of Medical Research
Sravanthi Devi Guggilapu, Guntuku Lalita, T Srinivasa Reddy, Santosh Kumar Prajapti, Atulya Nagarsenkar, Shymala Ramu, Uma Rani Brahma, Uppa Jaya Lakshmi, Ganga Modi Naidu Vegi, Suresh K Bhargava, Bathini Nagendra Babu
A series of C5-tethered Indolyl-3-glyoxylamide derivatives were synthesized and evaluated for their in vitro cytotoxic activity against DU145 (prostate), PC-3 (prostate), A549 (lung) and HCT-15 (colon) cancer cell lines by employing the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Among all the synthesized compounds, compound 7f displayed cytotoxicity of IC50 = 140 nM towards DU145 cancer cell line. The treatment of DU145 cells with 7f led to inhibition of cell migration ability...
January 22, 2017: European Journal of Medicinal Chemistry
K Obi Reddy, C Uma Maheswari, M S Dhlamini, B M Mothudi, Jinming Zhang, Jun Zhang, Rajini Nagarajan, A Varada Rajulu
In this study, we successfully extracted cellulose from borassus fruit fibers by chemical process. The extracted cellulose was dissolved in an ionic liquid 1-allyl-3-methylimidazolium chloride (AmimCl). Using this solution, regenerated cellulose films were prepared with water as the non solvent. The raw fruit fibers and extracted cellulose were characterized by chemical analysis. The results indicated that the content of the components other than cellulose was significantly decreased during the cellulose extraction process...
March 15, 2017: Carbohydrate Polymers
V V Robin, C K Vishnudas, Pooja Gupta, Frank E Rheindt, Daniel M Hooper, Uma Ramakrishnan, Sushma Reddy
BACKGROUND: A long-standing view of Indian biodiversity is that while rich in species, there are few endemics or in-situ radiations within the subcontinent. One exception is the Western Ghats biodiversity hotspot, an isolated mountain range with many endemic species. Understanding the origins of the montane-restricted species is crucial to illuminate both taxonomic and environmental history. RESULTS: With evidence from genetic, morphometric, song, and plumage data, we show that two songbird lineages endemic to the Western Ghats montane forest each have diversified into multiple distinct species...
January 23, 2017: BMC Evolutionary Biology
Michael W Varner, Madeline Murguia Rice, Mark B Landon, Brian M Casey, Uma M Reddy, Ronald J Wapner, Dwight J Rouse, Alan T N Tita, John M Thorp, Edward K Chien, George R Saade, Alan M Peaceman, Sean C Blackwell, J Peter Vandorsten
OBJECTIVE: To assess the association of subsequent pregnancy with subsequent metabolic syndrome and type II diabetes mellitus after a pregnancy complicated by mild gestational diabetes mellitus (GDM). METHODS: We conducted a prospective observational follow-up study of women with mild GDM randomized from 2002 to 2007 to usual care or dietary intervention and glucose self-monitoring. Women were evaluated 5-10 years after the parent study. Participants were grouped according to the number of subsequent pregnancies (group A, none [reference]; group B, one; group C, two or greater)...
February 2017: Obstetrics and Gynecology
Francesca L Facco, Corette B Parker, Uma M Reddy, Robert M Silver, Matthew A Koch, Judette M Louis, Robert C Basner, Judith H Chung, Chia-Ling Nhan-Chang, Grace W Pien, Susan Redline, William A Grobman, Deborah A Wing, Hyagriv N Simhan, David M Haas, Brian M Mercer, Samuel Parry, Daniel Mobley, Shannon Hunter, George R Saade, Frank P Schubert, Phyllis C Zee
OBJECTIVE: To estimate whether sleep-disordered breathing during pregnancy is a risk factor for the development of hypertensive disorders of pregnancy and gestational diabetes mellitus (GDM). METHODS: In this prospective cohort study, nulliparous women underwent in-home sleep-disordered breathing assessments in early (6-15 weeks of gestation) and midpregnancy (22-31 weeks of gestation). Participants and health care providers were blinded to the sleep test results...
January 2017: Obstetrics and Gynecology
Carla M Bann, Corette B Parker, William A Grobman, Marian Willinger, Hyagriv N Simhan, Deborah A Wing, David M Haas, Robert M Silver, Samuel Parry, George R Saade, Ronald J Wapner, Michal A Elovitz, Emily S Miller, Uma M Reddy
OBJECTIVE: To examine the psychometric properties of three measures, the perceived stress scale (PSS), pregnancy experience scale (PES), and state trait anxiety inventory (STAI), for assessing stress and anxiety during pregnancy among a large sample of nulliparous women. METHODS: The sample included 10,002 pregnant women participating in the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nMoM2b). Internal consistency reliability was assessed with Cronbach's alpha and factorial validity with confirmatory factor analyses...
November 10, 2016: Journal of Psychosomatic Obstetrics and Gynaecology
Sean C Blackwell, Mark B Landon, Lisa Mele, Uma M Reddy, Brian M Casey, Ronald J Wapner, Michael W Varner, Dwight J Rouse, John M Thorp, Anthony Sciscione, Patrick Catalano, George Saade, Steve N Caritis, Yoram Sorokin, William A Grobman
OBJECTIVE: To evaluate the relationships among excessive gestational weight gain, neonatal adiposity, and adverse obstetric outcomes in women with mild gestational diabetes mellitus. METHODS: This is a secondary analysis of a multicenter randomized clinical trial of women with mild gestational diabetes mellitus. Based on self-reported prepregnancy body weight, gestational weight gain was categorized as excessive if it was greater than 2009 Institute of Medicine guidelines...
December 2016: Obstetrics and Gynecology
Tetsuya Kawakita, Katherine L Grantz, Uma M Reddy, Anthony C Sciscione
No abstract text is available yet for this article.
November 2016: Obstetrics and Gynecology
Lynn M Yee, Grecio Sandoval, Jennifer Bailit, Uma M Reddy, Ronald J Wapner, Michael W Varner, Steve N Caritis, Mona Prasad, Alan T N Tita, George Saade, Yoram Sorokin, Dwight J Rouse, Sean C Blackwell, Jorge E Tolosa
OBJECTIVE: To describe factors associated with delayed pushing and evaluate the relationship between delayed pushing and perinatal outcomes in nulliparous women with singleton term gestations. METHODS: This was a secondary analysis of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Assessment of Perinatal Excellence cohort of 115,502 women and their neonates born in 25 U.S. hospitals from 2008 to 2011. Nulliparous women with singleton, cephalic, nonanomalous term births who achieved 10-cm cervical dilation were included...
November 2016: Obstetrics and Gynecology
P Lakshmi Raghavendra, Uma Ma, Srinivasa Rao, Yjv Reddy
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
B G Rohit, Srinivasa Rao, Uma, Harish, Yjv Reddy
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Riffat John, Uma Ganeshan, Badri N Singh, Tanushri Kaul, Malireddy K Reddy, Sudhir K Sopory, Manchikatla V Rajam
Topoisomerases are unique enzymes having an ability to remove or add DNA supercoils and untangle the snarled DNA. They can cut, shuffle, and religate DNA strands and remove the torsional stress during DNA replication, transcription or recombination events. In the present study, we over-expressed topoisomerase II (TopoII) in tobacco (Nicotiana tabaccum) and examined its role in growth and development as well as salt (NaCl) stress tolerance. Several putative transgenic plants were generated and the transgene integration and expression was confirmed by PCR and Southern blot analyses, and RT-PCR analysis respectively...
2016: Frontiers in Plant Science
William A Grobman, Corette Parker, Pathik D Wadhwa, Marian Willinger, Hyagriv Simhan, Bob Silver, Ron J Wapner, Samuel Parry, Brian Mercer, David Haas, Alan M Peaceman, Shannon Hunter, Deborah Wing, Steve Caritis, Sean Esplin, Matt Hoffman, Jack Ludmir, Jay Iams, Emily Long, George Saade, Uma M Reddy
Background The aim of this study was to determine whether racial/ethnic differences in psychosocial measures, independent of economic status, exist among a large population of pregnant nulliparas. Methods Between October 2010 and September 2013, nulliparous women at eight U.S. medical centers were followed longitudinally during pregnancy and completed validated instruments to quantify several psychosocial domains: Cohen Perceived Stress Scale, trait subscale of the Spielberger Anxiety Inventory, Connor-Davidson Resilience Scale, Multidimensional Scale of Perceived Social Support, Krieger Racism Scale, Edinburgh Postnatal Depression Scale, and the Pregnancy Experience Scale...
December 2016: American Journal of Perinatology
Rosemary J Froehlich, Grecio Sandoval, Jennifer L Bailit, William A Grobman, Uma M Reddy, Ronald J Wapner, Michael W Varner, John M Thorp, Mona Prasad, Alan T N Tita, George Saade, Yoram Sorokin, Sean C Blackwell, Jorge E Tolosa
OBJECTIVE: To evaluate the association between documentation of estimated fetal weight, and its value, with cesarean delivery. METHODS: This was a secondary analysis of a multicenter observational cohort of 115,502 deliveries from 2008 to 2011. Data were abstracted by trained and certified study personnel. We included women at 37 weeks of gestation or greater attempting vaginal delivery with live, nonanomalous, singleton, vertex fetuses and no history of cesarean delivery...
September 2016: Obstetrics and Gynecology
Tetsuya Kawakita, Uma M Reddy, Sara N Iqbal, Helain J Landy, Chun-Chih Huang, Matthew Hoffman, Anthony C Sciscione, Katherine L Grantz
OBJECTIVE: To compare maternal and neonatal outcomes based on length of the latent phase during induction with rupture of membranes before 6 cm dilation. METHODS: This is a retrospective cohort study using data from the Consortium of Safe Labor study, including 9,763 nulliparous and 8,379 multiparous women with singleton, term pregnancies undergoing induction at 2 cm dilation or less with rupture of membranes before 6 cm dilation after which the latent phase ended...
August 2016: Obstetrics and Gynecology
Robert M Silver, Leslie Myatt, John C Hauth, Kenneth J Leveno, Alan M Peaceman, Susan M Ramin, Philip Samuels, George Saade, Yoram Sorokin, Rebecca G Clifton, Uma M Reddy
Objective The objective of this study was to assess the relationship between first trimester cell-free total and fetal DNA in maternal plasma and the subsequent development of preeclampsia. Study Design Nested case-control study of patients enrolled in the Combined Antioxidant and Preeclampsia Prediction Studies prediction study of 175 women who did and 175 women who did not develop preeclampsia. The predictive values of cell-free total and fetal DNA and the subsequent development of preeclampsia were measured using receiver operating characteristic curves...
January 2017: American Journal of Perinatology
Uma Jyothi Kommoju, Subburaj Kadarkarai Samy, Jayaraj Maruda, Kumuda Irgam, Jaya Prasad Kotla, Lakshmi Velaga, Battini Mohan Reddy
BACKGROUND & OBJECTIVES: The genome-wide association studies (GWAS) have shown an association of type 2 diabetes mellitus (T2DM) with several novel genes. We report here the findings on the pattern of genetic association of three genes (CDKAL1, CDKN2A/B and HHEX) with T2DM in the population of Hyderabad, south India. METHODS: A sample of 1379 individuals (758 T2DM cases and 621 controls) from Hyderabad, India, were genotyped for five single nucleotide polymorphisms (SNPs) of CDKAL1 (rs7754840, rs7756992) CDKN2A/B (rs10811661) and HHEX (rs1111875, rs7923837) genes on Sequenom Mass Array platform...
April 2016: Indian Journal of Medical Research
Elizabeth A Thom, Madeline Murguia Rice, George R Saade, Uma M Reddy
For nearly 30 years the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network has been conducting randomized trials in pregnant women, many of which have changed clinical practice. Since 1986, the MFMU Network has conducted 29 randomized trials, of which the 17 trials started or completed since 2003 are described here. Study design choices are described including decisions regarding the fundamental questions to be answered and the rationale behind choices of primary and secondary outcomes...
August 2016: Seminars in Perinatology
P G Jacobs, J El Youssef, R Reddy, N Resalat, D Branigan, J Condon, N Preiser, K Ramsey, M Jones, C Edwards, K Kuehl, J Leitschuh, U Rajhbeharrysingh, J R Castle
AIMS: To test whether adjusting insulin and glucagon in response to exercise within a dual-hormone artificial pancreas (AP) reduces exercise-related hypoglycaemia. MATERIALS AND METHODS: In random order, 21 adults with type 1 diabetes (T1D) underwent three 22-hour experimental sessions: AP with exercise dosing adjustment (APX); AP with no exercise dosing adjustment (APN); and sensor-augmented pump (SAP) therapy. After an overnight stay and 2 hours after breakfast, participants exercised for 45 minutes at 60% of their maximum heart rate, with no snack given before exercise...
November 2016: Diabetes, Obesity & Metabolism
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