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Acute decompensated CHF

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https://www.readbyqxmd.com/read/28645802/comparative-effects-of-long-and-short-acting-loop-diuretics-on-mortality-in-patients-with-chronic-heart-failure
#1
Shu Kasama, Takuji Toyama, Masahiko Kurabayashi
BACKGROUND: We previously reported that the long-acting loop diuretic azosemide improves cardiac sympathetic nerve activity (CSNA) in patients with chronic heart failure (CHF), compared with short-acting furosemide. However, its influence on mortality has not been determined. METHODS: The present study was a further analysis of our previously published study in which azosemide showed improved (123)I-metaiodobenzylguanidine scintigraphic findings compared with furosemide in CHF patients with reduced left ventricular ejection fraction (LVEF)...
June 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28625318/prognostic-value-of-different-allelic-polymorphism-of-aldosterone-synthase-receptor-in-a-congestive-heart-failure-european-continental-ancestry-population
#2
Mauro Feola, Martino Monteverde, Daniela Vivenza, Marzia Testa, Laura Leto, Valentina Astesana, Francesco Mussapi, Antonello Vado, Marco Merlano, Cristiana Lo Nigro
Aldosterone synthase (CYP11B2) is as an 9-exon gene on chromosome 8q22 and exists as a common single nucleotide polymorphism C-T transition for position -344. The aim of this study was to assess the -344T/C polymorphism of the aldosterone synthase promoter in a European continental ancestry congestive heart failure (CHF) population. METHODS: Patients discharged after an acute decompensation were enrolled and underwent echocardiography, determination of BNP, evaluation of non-invasive cardiac outputs and determination of -344 T/C SNP in the aldosterone synthase gene...
February 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28598569/heart-failure-in-patients-admitted-for-acute-coronary-syndromes-a-report-from-a-large-national-registry
#3
Raban V Jeger, Otmar Pfister, Dragana Radovanovic, Franz R Eberli, Hans Rickli, Philip Urban, Giovanni Pedrazzini, Jean-Christophe Stauffer, Jörg Nossen, Paul Erne
BACKGROUND: Data on temporal trends of heart failure (HF) in acute coronary syndrome (ACS) are scarce. HYPOTHESIS: Improved treatment options may have led to lower case-fatality rates (CFRs) during the last years in ACS complicated by HF. METHODS: Patients of the nationwide Acute Myocardial Infarction in Switzerland (AMIS)-Plus ACS registry were analyzed from 2000 to 2014. RESULTS: Of 36 366 ACS patients, 3376 (9.3%) had acute or chronic HF, 2111 (5...
June 9, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28583677/how-trialists-and-pharmaceutical-sponsors-have-failed-us-by-thinking-that-acute-heart-failure-is-a-48-hour-illness
#4
EDITORIAL
Peter A McCullough
Trials of novel therapies for acute heart failure (HF) have followed a convention of short term, most commonly a 48-hour infusion of parenteral therapy compared with placebo or an active drug in a randomized, double-blind study design. Such trials include OPTIME-CHF, SURVIVE, VERITAS, PROTECT, ASCEND-HF, TRUE-HF, and RELAX-AHF-2. This article reviews how this practice in trials began and summarizes the reasons why such a brief exposure of any novel therapy has failed to reduce the end points of rehospitalization or death...
August 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28290905/-therapy-of-high-risk-patients-after-decompensation-of-heart-failure-under-nt-probnp-control-main-results
#5
A A Skvortsov, D E Koshkina, O Yu Narusov, V N Protasov, V P Masenko, S N Tereshchenko
AIM: to compare efficacy of treatment of high risk patients after acute decompensation (AD) of chronic heart failure (CHF) based on monitoring of NT-proBNP concentration and standard treatment. MATERIAL AND METHODS: Patients (n=100) with class III-IV CHF and left ventricular ejection fraction (LV EF) <40% due to ischemic heart disease (IHD), dilated cardiomyopathy (DCMP), or arterial hypertension (AH) after compensation of HF before discharge were distributed into groups of low (NT-proBNP <1400 picog/ml, n=30) or high (NT-proBNP more or equal 1400 picog/ml, n=70) risk...
July 2016: Kardiologiia
https://www.readbyqxmd.com/read/28262214/hospital-management-of-acute-decompensated-heart-failure
#6
REVIEW
Ashraf S Abdo
Heart failure (HF) is one of the leading causes of hospitalizations for elderly adults in the United States. One in 5 Americans will be >65 years of age by 2050. Because of the high prevalence of HF in this group, the number of Americans requiring hospitalization for this disorder is expected to rise significantly. We reviewed the most recent and ongoing studies and recommendations for the management of patients hospitalized due to decompensated HF. The Acute Decompensated Heart Failure National Registry, together with the 2013 American College of Cardiology Foundation and American Heart Association heart failure guidelines, earlier retrospective and prospective studies including the Diuretic Optimization Strategies Evaluation (DOSE), the Trial of Intensified vs Standard Medical Therapy in the Elderly Patients With Congestive Heart Failure (TIME-CHF), the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF), the Rapid Emergency Department Heart Failure Outpatient Trial (REDHOT) and the Comparison of Medical, Pacing and Defibrillation Therapies in Heart Failure (COMPANION) trial were reviewed for current practices pertaining to these patients...
March 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27788390/inflammation-versus-mechanical-stretch-biomarkers-over-time-in-acutely-decompensated-heart-failure-with-reduced-ejection-fraction
#7
M Boulogne, M Sadoune, J M Launay, M Baudet, A Cohen-Solal, D Logeart
Heart failure can be associated with inflammation but it is unclear if inflammation is directly related to hemodynamic worsening or is an independent pathway. Our aim was to investigate inflammation and mechanical stress using serial measurements of biomarkers in acute and chronic heart failure with reduced ejection fraction (AHF and CHF). METHOD: The following biomarkers were measured on admission, at discharge and one month after discharge: B-type natriuretic peptide (BNP), high-sensitivity C-Reactive protein (hsCRP), Tumour Necrosis Factor alpha (TNFα), interleukin 6 (IL6), myeloperoxidase (MPO), suppression of tumorigenicity 2 (ST2), mid-regional pro-adrenomedullin (MR-proADM), galectin 3 (Gal3), Growth differentiating factor 15 (GDF15) and procalcitonin (PCT)...
January 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27782093/effects-of-hyponatremia-normalization-on-the-short-term-mortality-and-rehospitalizations-in-patients-with-recent-acute-decompensated-heart-failure-a-retrospective-study
#8
Renato De Vecchis, Marco Di Maio, Giuseppina Di Biase, Carmelina Ariano
Background: Several studies have shown that hyponatremia is associated with increased risk of rehospitalization and death in patients with heart failure. In these studies, chronic heart failure (CHF) patients with persistent hyponatremia were compared only with CHF patients with a normal sodium level at hospital admission. Aims: In the present retrospective study, conducted in a cohort of patients with recent acute decompensated heart failure (ADHF), all with hyponatremia ascertained at the time of hospital admission, we aimed to evaluate the effect of the normalization of serum sodium on the composite endpoint of short-term rehospitalization and mortality...
October 22, 2016: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/27755944/natriuretic-peptides-and-their-therapeutic-potential-in-heart-failure-treatment-an-updated-review
#9
REVIEW
M Namdari, A Eatemadi, B Negahdari
Brain natriuretic peptide (BNP), also known as a B-type natriuretic peptide, is one of the important biomarkers with a proven role in the diagnosis of congestive heart failure (CHF). Researchers from the different clinical field have researched into the performance features of BNP testing in the acute care set-up to assist and improve in diagnosing CHF and in predicting future morbidity and mortality rates. The potency of BNP has also been researched into in cases like myocardial ischemia and infarction, cor pulmonale, and acute pulmonary embolism (PE)...
September 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27741422/newly-diagnosed-and-decompensated-congestive-heart-failure-is-associated-with-increased-rates-of-pneumonia-reintubation-and-death-following-laparoscopic-cholecystectomy-a-nsqip-database-review-of-143-761-patients
#10
Chad M Hall, Daniel C Jupiter, Justin L Regner
BACKGROUND: Laparoscopic cholecystectomy (LC) is routinely performed as an outpatient operation. NSQIP tracks acute or symptomatic congestive heart failure (CHF) within 30 days of the index operation. This study aims to quantify adverse events after LC and determine if patients with CHF may benefit from pre-operative optimization or post-operative admission. MATERIALS AND METHODS: This is a retrospective NSQIP database review of all adults undergoing LC between 2008 and 2012...
November 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27669547/role-of-isolated-ultrafiltration-in-the-management-of-chronic-refractory-and-acute-decompensated-heart-failure
#11
Mayank K Mittal, Natraj Katta, Martin A Alpert
Chronic congestive heart failure (CHF) and acute decompensated heart failure (ADHF) refractory to medical therapy represent therapeutic challenges. In such patients, attempts to reduce pulmonary and systemic congestion frequently produce deterioration of renal function. In studies of patients with chronic severe CHF refractory to medical therapy (including loop diuretics), isolated ultrafiltration was frequently able to relieve congestive symptoms by precise removal of extracellular water and sodium, and in some cases was able to restore responsiveness to loop diuretics...
October 2016: Hemodialysis International
https://www.readbyqxmd.com/read/27568891/adherence-to-positive-airway-pressure-therapy-in-hospitalized-patients-with-decompensated-heart-failure-and-sleep-disordered-breathing
#12
Sunil Sharma, Anasua Chakraborty, Anindita Chowdhury, Umer Mukhtar, Leslee Willes, Stuart F Quan
STUDY OBJECTIVES: Sleep-disordered breathing (SDB) has been implicated as a risk factor for the development of several adverse cardiovascular outcomes, but can be mitigated with positive airway pressure therapy (PAP). The nonadherence of patients with SDB on PAP in the outpatient setting ranges from 29% to 84%. However, adherence of PAP in patients with congestive heart failure (CHF) admitted for decompensated CHF and in whom SDB has been diagnosed in the hospital setting is not known...
December 15, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/27401733/right-ventricular-dysfunction-as-predictor-of-longer-hospital-stay-in-patients-with-acute-decompensated-heart-failure-a-prospective-study-in-indonesian-population
#13
Paskariatne Probo Dewi Yamin, Sunu Budhi Raharjo, Vebiona Kartini Prima Putri, Nani Hersunarti
BACKGROUND: Hospital length of stay (LOS) is a key determinant of heart failure hospitalization costs. Longer LOS is associated with lower quality of care measures and higher rates of readmission and mortality. Right ventricular (RV) dysfunction predicted poor outcomes in patients with stable chronic heart failure (CHF), however, its prognostic value in the acute decompensated heart failure (ADHF) patients has not been sufficiently clarified. This study investigated the prognostic value of RV dysfunction in predicting longer LOS in ADHF patients...
July 11, 2016: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/27379611/betawin-ahf-study-effect-of-beta-blocker-withdrawal-during-acute-decompensation-in-patients-with-chronic-heart-failure
#14
MULTICENTER STUDY
Òscar Miró, Christian Müller, Francisco Javier Martín-Sánchez, Héctor Bueno, Alexander Mebazaa, Pablo Herrero, Javier Jacob, Víctor Gil, Rosa Escoda, Pere Llorens
OBJECTIVE: To evaluate the effects of discontinuing chronic beta-blocker (BB) treatment on short-term outcome in patients with chronic heart failure (CHF) during acute decompensation. METHODS: We selected all the patients previously diagnosed with CHF and currently on BB and attended for acute heart failure (AHF) in one of the 35 Spanish emergency departments participating in the EAHFE registry. Patients were classified according to BB maintenance or withdrawal (BBM or BBW, respectively) during the episode...
December 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/27279845/clinical-factors-associated-with-early-readmission-among-acutely-decompensated-heart-failure-patients
#15
Bredy Pierre-Louis, Shareen Rodriques, Vanessa Gorospe, Achuta K Guddati, Wilbert S Aronow, Chul Ahn, Maurice Wright
INTRODUCTION: Congestive heart failure (CHF) is a common cause of hospital readmission. MATERIAL AND METHODS: A retrospective study was conducted at Harlem Hospital in New York City. Data were collected for 685 consecutive adult patients admitted for decompensated CHF from March, 2009 to December, 2012. Variables including patient demographics, comorbidities, laboratory studies, and medical therapy were compared between CHF patient admissions resulting in early CHF readmission and not resulting in early CHF readmission...
June 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/26991036/prognostic-incremental-role-of-right-ventricular-function-in-acute-decompensation-of-advanced-chronic-heart-failure
#16
Simone Frea, Stefano Pidello, Virginia Bovolo, Cristina Iacovino, Erica Franco, Francesco Pinneri, Alessandro Galluzzo, Alessandra Volpe, Massimiliano Visconti, Andrea Peirone, Mara Morello, Serena Bergerone, Fiorenzo Gaita
AIMS: The purpose of this study was to evaluate the additional prognostic value of echocardiography in acute decompensation of advanced chronic heart failure (CHF), focusing on right ventricular (RV) dysfunction and its interaction with loading conditions. Few data are available on the prognostic role of echocardiography in acute HF and on the significance of pulmonary hypertension in patients with severe RV failure. METHODS AND RESULTS: A total of 265 NYHA IV patients admitted for acute decompensation of advanced CHF (EF 22 ± 7%, systolic blood pressure 107 ± 20 mmHg) were prospectively enrolled...
May 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/26872673/the-role-of-inflammation-and-cell-death-in-the-pathogenesis-progression-and-treatment-of-heart-failure
#17
REVIEW
Alexandros Briasoulis, Emmanuel Androulakis, Theodoros Christophides, Dimitris Tousoulis
Chronic inflammation underlies a variety of seemingly unrelated conditions including coronary artery disease. The interest in exploring the role of inflammation in heart failure (CHF) arises from earlier observations that circulating pro-inflammatory biomarker levels are elevated in patients with both ischaemic and non-ischaemic cardiomyopathies and correlate with severity of disease and prognosis (McMurray et al. in Eur Heart J 33:1787-1847, 2012; Mosterd and Hoes in Heart 93:1137-1146, 2007; Owan et al. in New Engl J Med 355:251-259, 2006)...
March 2016: Heart Failure Reviews
https://www.readbyqxmd.com/read/26870386/comparative-effects-of-long-acting-and-short-acting-loop-diuretics-on-cardiac-sympathetic-nerve-activity-in-patients-with-chronic-heart-failure
#18
Yae Matsuo, Shu Kasama, Takuji Toyama, Ryuichi Funada, Noriaki Takama, Norimichi Koitabashi, Shuichi Ichikawa, Yasuyuki Suzuki, Naoya Matsumoto, Yuichi Sato, Masahiko Kurabayashi
OBJECTIVE: Short-acting loop diuretics are known to enhance cardiac sympathetic nerve activity (CSNA) in patients with chronic heart failure (CHF). The effects of two loop diuretics-long-acting azosemide and short-acting furosemide-on CSNA were evaluated using (123)I-metaiodobenzylguanidine (MIBG) scintigraphy in patients with CHF. METHODS: The present study was a subanalysis of our previously published study, which had reported that serial (123)I-MIBG studies were the most useful prognostic indicator in patients with CHF...
2016: Open Heart
https://www.readbyqxmd.com/read/26663664/flow-reduction-in-high-flow-arteriovenous-fistulas-improve-cardiovascular-parameters-and-decreases-need-for-hospitalization
#19
Saravanan Balamuthusamy, Nishant Jalandhara, Anand Subramanian, Arvindselvan Mohanaselvan
High output heart failure (HF) and pulmonary hypertension have been demonstrated in patients with prevalent arteriovenous (AV) fistulas. Fistulas with flow >2000 mL/minutes are more likely to induce changes in cardiac geometry and pulmonary artery pressure. The effects of reducing flow in AV access and its implications on HF decompensation and hospitalizations have not been studied. Retrospective analysis of 12 patients who needed hospitalization for acute Congestive Heart Failure (CHF) decompensation with AV access flow of 2 L/minutes (as defined by Kidney Disease Outcomes Quality Initiative (KDOQI)) or more were included in the study...
July 2016: Hemodialysis International
https://www.readbyqxmd.com/read/26615619/-first-open-study-of-syndrome-of-acute-decompensation-of-heart-failure-and-concomitant-diseases-in-russian-federation-independent-registry-orakul
#20
MULTICENTER STUDY
A G Arutyunov, D O Dragunov, G P Arutyunov, A K Rylova, D D Pashkevich, K V Viter
Aim of the study was to assess mortality and rate of repetitive hospital admissions on days 30, 90, 180, 360, of observation as well as prevalence of concomitant diseases in patients with congestive heart failure (CHF). The register was formed in 41 centers of 20 cities of Russian Federation. Number of included patients with signs of chronic heart failure (CHF) was 2498. Data on 2404 was available for final analysis. Rehospitalization rate was 31, 11, 11, and 9.5% during 30 days, and during periods 31-90, 91-180, 181-360 days after discharge from hospital, respectively...
2015: Kardiologiia
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