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JOURNAL ARTICLE
Yaning Wang, Zihao Wang, Xiaopeng Guo, Yaning Cao, Hao Xing, Yuekun Wang, Bing Xing, Yu Wang, Yong Yao, Wenbin Ma
BACKGROUND: Immune checkpoint inhibitors (ICIs) are a promising immunotherapy approach, but glioblastoma clinical trials have not yielded satisfactory results. OBJECTIVE: To screen glioblastoma patients who may benefit from immunotherapy. METHODS: Eighty-one patients receiving anti-PD1/PD-L1 treatment from a large-scale clinical trial and 364 patients without immunotherapy from The Cancer Genome Atlas (TCGA) were included. Patients in the ICI-treated cohort were divided into responders and nonresponders according to overall survival (OS), and the most critical responder-relevant features were screened using random forest (RF)...
May 2024: Cancer Medicine
#22
JOURNAL ARTICLE
Daniel Freinhofer, Philipp Schwartenbeck, Natasha Thon, Wolfgang Aichhorn, Melanie Lenger, Friedrich M Wurst, Martin Kronbichler
Impaired decision-making is often displayed by individuals suffering from gambling disorder (GD). Since there are a variety of different phenomena influencing decision-making, we focused in this study on the effects of GD on neural and behavioural processes related to loss aversion and choice difficulty. Behavioural responses as well as brain images of 23 patients with GD and 20 controls were recorded while they completed a mixed gambles task, where they had to decide to either accept or reject gambles with different amounts of potential gain and loss...
May 2024: Addiction Biology
#23
JOURNAL ARTICLE
Francisco García-Córdova, Antonio Guerrero-González, Fernando Hidalgo-Castelo
This article presents a study on the neurobiological control of voluntary movements for anthropomorphic robotic systems. A corticospinal neural network model has been developed to control joint trajectories in multi-fingered robotic hands. The proposed neural network simulates cortical and spinal areas, as well as the connectivity between them, during the execution of voluntary movements similar to those performed by humans or monkeys. Furthermore, this neural connection allows for the interpretation of functional roles in the motor areas of the brain...
May 3, 2024: Sensors
#24
JOURNAL ARTICLE
Manob Jyoti Saikia, Arar Salim Alkhader
Concussions, a prevalent public health concern in the United States, often result from mild traumatic brain injuries (mTBI), notably in sports such as American football. There is limited exploration of smart-textile-based sensors for measuring the head impacts associated with concussions in sports and recreational activities. In this paper, we describe the development and construction of a smart textile impact sensor (STIS) and validate STIS functionality under high magnitude impacts. This STIS can be inserted into helmet cushioning to determine head impact force...
May 3, 2024: Sensors
#25
JOURNAL ARTICLE
You Zhou, Pukun Chen, Yifan Fan, Yin Wu
Modern society increasingly recognizes brain fatigue as a critical factor affecting human health and productivity. This study introduces a novel, portable, cost-effective, and user-friendly system for real-time collection, monitoring, and analysis of physiological signals aimed at enhancing the precision and efficiency of brain fatigue recognition and broadening its application scope. Utilizing raw physiological data, this study constructed a compact dataset that incorporated EEG and ECG data from 20 subjects to index fatigue characteristics...
May 2, 2024: Sensors
#26
JOURNAL ARTICLE
Antonio Cuccaro, Angela Dell'Aversano, Bruno Basile, Maria Antonia Maisto, Raffaele Solimene
In this contribution, a wearable microwave imaging system for real-time monitoring of brain stroke in the post-acute stage is described and validated. The system exploits multistatic/multifrequency (only 50 frequency samples) data collected via a low-cost and low-complexity architecture. Data are collected by an array of only 16 antennas moved by pneumatic system. Phantoms, built from ABS material and filled with appropriate Triton X-100-based mixtures to mimic the different head human tissues, are employed for the experiments...
April 30, 2024: Sensors
#27
JOURNAL ARTICLE
Gaia Bonassi, Mingqi Zhao, Jessica Samogin, Dante Mantini, Roberta Marchese, Luciano Contrino, Paola Tognetti, Martina Putzolu, Alessandro Botta, Elisa Pelosin, Laura Avanzino
Walking encompasses a complex interplay of neuromuscular coordination and cognitive processes. Disruptions in gait can impact personal independence and quality of life, especially among the elderly and neurodegenerative patients. While traditional biomechanical analyses and neuroimaging techniques have contributed to understanding gait control, they often lack the temporal resolution needed for rapid neural dynamics. This study employs a mobile brain/body imaging (MoBI) platform with high-density electroencephalography (hd-EEG) to explore event-related desynchronization and synchronization (ERD/ERS) during overground walking...
April 30, 2024: Sensors
#28
REVIEW
Gayathree Thenuwara, Bilal Javed, Baljit Singh, Furong Tian
Glioblastoma, an aggressive primary brain tumor, poses a significant challenge owing to its dynamic and intricate tumor microenvironment. This review investigates the innovative integration of biosensor-enhanced organ-on-a-chip (OOC) models as a novel strategy for an in-depth exploration of glioblastoma tumor microenvironment dynamics. In recent years, the transformative approach of incorporating biosensors into OOC platforms has enabled real-time monitoring and analysis of cellular behaviors within a controlled microenvironment...
April 30, 2024: Sensors
#29
JOURNAL ARTICLE
Tustanah Phukhachee, Suthathip Maneewongvatana, Chayapol Chaiyanan, Keiji Iramina, Boonserm Kaewkamnerdpong
Being motivated has positive influences on task performance. However, motivation could result from various motives that affect different parts of the brain. Analyzing the motivation effect from all affected areas requires a high number of EEG electrodes, resulting in high cost, inflexibility, and burden to users. In various real-world applications, only the motivation effect is required for performance evaluation regardless of the motive. Analyzing the relationships between the motivation-affected brain areas associated with the task's performance could limit the required electrodes...
April 30, 2024: Sensors
#30
JOURNAL ARTICLE
Lucía Penalba-Sánchez, Gabriel Silva, Mark Crook-Rumsey, Alexander Sumich, Pedro Miguel Rodrigues, Patrícia Oliveira-Silva, Ignacio Cifre
Understanding and classifying brain states as a function of sleep quality and age has important implications for developing lifestyle-based interventions involving sleep hygiene. Current studies use an algorithm that captures non-linear features of brain complexity to differentiate awake electroencephalography (EEG) states, as a function of age and sleep quality. Fifty-eight participants were assessed using the Pittsburgh Sleep Quality Inventory (PSQI) and awake resting state EEG. Groups were formed based on age and sleep quality (younger adults n = 24, mean age = 24...
April 28, 2024: Sensors
#31
JOURNAL ARTICLE
Qirui Zhang, Ruixuan Wei, Songlin Huang
A highly intelligent system often draws lessons from the unique abilities of humans. Current humanlike models, however, mainly focus on biological behavior, and the brain functions of humans are often overlooked. By drawing inspiration from brain science, this article shows how aspects of brain processing such as sensing, preprocessing, cognition, obstacle learning, behavior, strategy learning, pre-action, and action can be melded together in a coherent manner with cognitive control architecture. This work is based on the notion that the anti-collision response is activated in sequence, which starts from obstacle sensing to action...
April 27, 2024: Sensors
#32
JOURNAL ARTICLE
Takahiro Kawaguchi, Koki Ono, Hiroomi Hikawa
Brain-computer interfaces (BCIs) allow information to be transmitted directly from the human brain to a computer, enhancing the ability of human brain activity to interact with the environment. In particular, BCI-based control systems are highly desirable because they can control equipment used by people with disabilities, such as wheelchairs and prosthetic legs. BCIs make use of electroencephalograms (EEGs) to decode the human brain's status. This paper presents an EEG-based facial gesture recognition method based on a self-organizing map (SOM)...
April 25, 2024: Sensors
#33
REVIEW
Freiser Eceomo Cruz Mosquera, Santiago Lizcano Martinez, Yamil Liscano
In this study, a systematic review of randomized clinical trials conducted from January 2000 to December 2023 was performed to examine the efficacy of psychobiotics-probiotics beneficial to mental health via the gut-brain axis-in adults with psychiatric and cognitive disorders. Out of the 51 studies involving 3353 patients where half received psychobiotics, there was a notably high measurement of effectiveness specifically in the treatment of depression symptoms. Most participants were older and female, with treatments commonly utilizing strains of Lactobacillus and Bifidobacteria over periods ranging from 4 to 24 weeks...
April 30, 2024: Nutrients
#34
REVIEW
Hind Moukham, Alessia Lambiase, Giovanni Davide Barone, Farida Tripodi, Paola Coccetti
Natural products from mushrooms, plants, microalgae, and cyanobacteria have been intensively explored and studied for their preventive or therapeutic potential. Among age-related pathologies, neurodegenerative diseases (such as Alzheimer's and Parkinson's diseases) represent a worldwide health and social problem. Since several pathological mechanisms are associated with neurodegeneration, promising strategies against neurodegenerative diseases are aimed to target multiple processes. These approaches usually avoid premature cell death and the loss of function of damaged neurons...
April 26, 2024: Nutrients
#35
JOURNAL ARTICLE
Xuejing Sun, Cui Zhou, Mengwei Ju, Wenjing Feng, Zhiting Guo, Chengyan Qi, Kexin Yang, Rong Xiao
The abnormality in N6-methyladenosine (m6A) methylation is involved in the course of Alzheimer's disease (AD), while the intervention of 27-Hydroxycholesterol (27-OHC) can affect the m6A methylation modification in the brain cortex. Disordered gut microbiota is a key link in 27-OHC leading to cognitive impairment, and further studies have found that the abundance of Roseburia intestinalis in the gut is significantly reduced under the intervention of 27-OHC. This study aims to investigate the association of 27-OHC, Roseburia intestinalis in the gut, and brain m6A modification in the learning and memory ability injury...
April 26, 2024: Nutrients
#36
JOURNAL ARTICLE
Fusheng Cui, Huihui Li, Yi Cao, Weijing Wang, Dongfeng Zhang
Few studies have examined dietary protein intake and sources, in combination with longitudinal changes in brain structure markers. Our study aimed to examine the association between dietary protein intake and different sources of dietary protein, with the longitudinal rate of change in brain structural markers. A total of 2723 and 2679 participants from the UK Biobank were separately included in the analysis. The relative and absolute amounts of dietary protein intake were calculated using a 24 h dietary recall questionnaire...
April 25, 2024: Nutrients
#37
JOURNAL ARTICLE
Yu Mu, Yalin Yang, Shuang Jiang, Chilu Liu, Yanxing Han, Jiandong Jiang, Yuhong Wang
Metabolic syndrome (MetS) is a cluster of risk factors for cardiovascular diseases (CVDs) that has become a global public health problem. Puerarin (PUE), the principal active compound of Pueraria lobata, has the effects of regulating glucose and lipid metabolism and protecting against cardiovascular damage. This study aimed to investigate whether dietary supplementation with PUE could ameliorate MetS and its associated cardiovascular damage. Rats were randomly divided into three groups: the normal diet group (NC), the high-fat/high-sucrose diet group (HFHS), and the HFHS plus PUE diet group (HFHS-PUE)...
April 25, 2024: Nutrients
#38
REVIEW
Kinga Borowicz-Reutt, Marlena Krawczyk, Julia Czernia
Epilepsy is one of the most disabling neurological diseases. Despite proper pharmacotherapy and the availability of 2nd and 3rd generation antiepileptic drugs, deep brain stimulation, and surgery, up to 30-40% of epilepsy patients remain drug-resistant. Consequences of this phenomenon include not only decreased a quality of life, and cognitive, behavioral, and personal disorders, but also an increased risk of death, i.e., in the mechanism of sudden unexpected death in epilepsy patients (SUDEP). The main goals of epilepsy treatment include three basic issues: achieving the best possible seizure control, avoiding the undesired effects of treatment, and maintaining/improving the quality of patients' lives...
April 24, 2024: Nutrients
#39
JOURNAL ARTICLE
Marc Dörner, Katharina Seebach, Michael T Heneka, Inga Menze, Roland von Känel, Sebastian Euler, Frank Schreiber, Philipp Arndt, Katja Neumann, Annkatrin Hildebrand, Anna-Charlotte John, Anthony Tyndall, Johannes Kirchebner, Pawel Tacik, Robin Jansen, Alexander Grimm, Solveig Henneicke, Valentina Perosa, Sven G Meuth, Oliver Peters, Julian Hellmann-Regen, Lukas Preis, Josef Priller, Eike Jakob Spruth, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Frank Jessen, Ayda Rostamzadeh, Wenzel Glanz, Jan Ben Schulze, Sarah Lavinia Florence Schiebler, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, Matthias H Munk, Annika Spottke, Nina Roy-Kluth, Michael Wagner, Ingo Frommann, Falk Lüsebrink, Peter Dechent, Stefan Hetzer, Klaus Scheffler, Luca Kleineidam, Melina Stark, Matthias Schmid, Ersin Ersözlü, Frederic Brosseron, Michael Ewers, Björn H Schott, Emrah Düzel, Gabriel Ziegler, Hendrik Mattern, Stefanie Schreiber, Jose Bernal
Inferior frontal sulcal hyperintensities (IFSHs) on fluid-attenuated inversion recovery (FLAIR) sequences have been proposed to be indicative of glymphatic dysfunction. Replication studies in large and diverse samples are nonetheless needed to confirm them as an imaging biomarker. We investigated whether IFSHs were tied to Alzheimer's disease (AD) pathology and cognitive performance. We used data from 361 participants along the AD continuum, who were enrolled in the multicentre DELCODE study. The IFSHs were rated visually based on FLAIR magnetic resonance imaging...
April 30, 2024: Diagnostics
#40
JOURNAL ARTICLE
Radina Kirkova, Svetla Dineva, Elisa Stradiotto, Ivan Tanev, Alessandra Di Maria
A 77-year-old-man with arterial hypertension, diabetes mellitus type II presented at our clinic for a routine ophthalmological exam. He complained of intermittent double vision. The ophthalmic examination revealed paralysis of III (n. oculomotorius) and VI (n. abducens) cranial nerves with ptosis, deficit in elevation and abduction of the left eye. The patient underwent urgent MRI imaging of the brain/orbits and paranasal sinuses, and urgent neurological assessment. MRI revealed a volume-occupying process, starting from the posterior wall of the left maxillary sinus with perineural diffusion and involvement of the homolateral trigeminal nerve, intracranial spread in the medial cranial fossa and involvement of the cavernous, sphenoidal sinuses and the orbital apex on the left side...
April 29, 2024: Diagnostics
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