Chunqing Wang, Xin Huang, Ziyan Tang, Yizhi Zhang, Meng Wei, Shumin Du, Xingshuang Song, Yanping Wu, Qiang Chi, Xiaomei Zhuang, Du Lina, Yiguan Jin
Sleep disorders are one of the most common acute reactions on the plateau, which can cause serious complications. However, there is no effective and safe treatment currently available. Nimodipine (NMD) is a dihydropyridine calcium channel blocker with neuroprotective and vasodilating activity, mainly used for the treatment of ischemic brain injury. Commercial oral or injectable NMD formulations are not a good option for central neuron diseases due to their poor brain delivery. In this study, nimodipine dissolving microneedles (NDMNs) were prepared for the prevention of sleep disorders caused by hypoxia...
April 16, 2024: Pharmaceutical Development and Technology