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Markus O Scheinhardt, Tamara Lerman, Inke R König, Georg Griesinger
STUDY QUESTION: What is the performance of previously established regression models in predicting low and high ovarian response to 150 μg corifollitropin alfa/GnRH-antagonist ovarian stimulation in an independent dataset? SUMMARY ANSWER: The outcome of ovarian stimulation with 150 μg corifollitropin alfa in a fixed, multiple dose GnRH-antagonist protocol can be validly predicted using logistic regression models with AMH being of paramount importance. WHAT IS KNOWN ALREADY: Predictors of ovarian response have been identified in FSH/GnRH agonist protocols as well as ovarian stimulation with corifollitropin alfa/GnRH-antagonist...
July 10, 2018: Human Reproduction
Sabrina Elisa Oliveira, Pauliane Melo Costa, Sara Batista Nascimento, Whocely Victor Castro, Rosy Iara Maciel de Azambuja Ribeiro, Hélio Batista Santos, Ralph Gruppi Thomé
Atrazine is a herbicide that is banned in Europe but remains widely used on different types of crops in several countries in the American continent. Atrazine is known to be an endocrine disruptor and its effects on gonads have been extensively reported, but the toxic action on other organs is poorly documented. In this paper, we investigated the toxicity of atrazine on the gills and spleens of Nile tilapia (Oreochromis niloticus). The median lethal concentration (LC50 ), capable of killing one-half of the test animals was calculated, and sublethal concentrations of atrazine were used in a semistatic and subchronic assay...
July 2, 2018: Aquatic Toxicology
Kevin W Jackman, Nik Veldhoen, Rachel C Miliano, Bonnie J Robert, Linda Li, Azadeh Khojasteh, Xiaoyu Zheng, Tristan S M Zaborniak, Graham van Aggelen, Mary Lesperance, Wayne J Parker, Eric R Hall, Gregory G Pyle, Caren C Helbing
Thyroid hormones (THs) regulate vertebrate growth, development, and metabolism. Despite their importance, there is a need for effective detection of TH-disruption by endocrine disrupting chemicals (EDCs). The frog olfactory system substantially remodels during TH-dependent metamorphosis and the objective of the present study is to examine olfactory system gene expression for TH biomarkers that can evaluate the biological effects of complex mixtures such as municipal wastewater. We first examine classic TH-response gene transcripts using reverse transcription-quantitative real-time polymerase chain reaction (RT-qPCR) in the olfactory epithelium (OE) and olfactory bulb (OB) of premetamorphic Rana (Lithobates) catesbeiana tadpoles after 48 h exposure to biologically-relevant concentrations of the THs, 3,5,3'-triiodothyronine (T3 ) and L-thyroxine (T4 ), or 17-beta estradiol (E2 ); a hormone that can crosstalk with THs...
June 30, 2018: Aquatic Toxicology
Clemilson Berto-Júnior, Ana Paula Santos-Silva, Andrea Claudia Freitas Ferreira, Jones Bernades Graceli, Denise Pires de Carvalho, Paula Soares, Nelilma Correia Romeiro, Leandro Miranda-Alves
Bisphenol A (BPA) is a well-known endocrine disruptor with several effects on reproduction, development, and cancer incidence, and it is highly used in the plastic industry. Bisphenol S (BPS) was proposed as an alternative to BPA since it has a similar structure and can be used to manufacture the same products. Some reports show that BPA interferes with thyroid function, but little is known about the involvement of BPS in thyroid function or how these molecules could possibly modulate at the same time the principal genes involved in thyroid physiology...
July 13, 2018: Environmental Science and Pollution Research International
Franz J Legat
Phototherapy and photochemotherapy (PUVA) are important treatment modalities in inflammatory skin diseases such as psoriasis and atopic dermatitis as well as in cutaneous T‑cell lymphoma (e.g., mycosis fungoides/Sezary syndrome). Many of these skin diseases are accompanied by distracting pruritus. In addition, patients may suffer from intense pruritus in systemic diseases of the kidney and liver as well as of the endocrine and hematopoietic system. UV-light during phototherapy is capable of not only improving the inflammatory skin lesions but also of reducing the pruritus in skin and systemic diseases...
July 13, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
George B Stefano, Richard M Kream
Today's medical service delivery platforms provide everything from small urgent care 'offices' to large medical centers. Since 2007, an intermediate entity for care has been established, namely, the micro-hospital. Micro-hospitals are 24-hour, small inpatient facilities with an average of 2 to 10 beds, designed to provide a diversity of healthcare services consistent with community demands. In addition, they seek to combine a cost-effective healthcare vehicle with potential time-dependent triage/transfer capabilities to a nearby large medical center...
July 14, 2018: Medical Science Monitor Basic Research
Vince Kornél Grolmusz, Annamária Kövesdi, Katalin Borka, Peter Igaz, Attila Patocs
Objective Pancreatic neuroendocrine neoplasms (PanNENs) are rare tumors arising from the endocrine pancreas, however their prognosis differs significantly upon their proliferative state which is characterized by histopathological grading. MiRNAs are small, noncoding RNAs posttranscriptionally regulating gene expression. Our aim was to identify miRNAs with altered expression upon proliferation which can be used as prognostic biomarkers in PanNENs. Methods MiRNA expression profiles of 40 PanNENs were downloaded from Gene Expression Omnibus and were reanalyzed upon tumor grades (discovery cohort)...
July 13, 2018: European Journal of Endocrinology
Nicolas Nicolaides, George Chrousos
Glucocorticoids signal through their cognate, ubiquitously expressed glucocorticoid receptor (GR), which influences the transcription of a large number of target genes. Several genetic defects, including point mutations, deletions or insertions in the NR3C1 gene that encodes the GR, have been associated with familial or sporadic generalized glucocorticoid resistance or Chrousos syndrome. One of the clinical manifestations of this rare endocrine condition is bilateral adrenal hyperplasia due to compensatory elevations of plasma ACTH concentrations...
July 13, 2018: European Journal of Endocrinology
Peter Day, Richard M Green, Melanie Gross, Lennart Weltje, James R Wheeler
The ongoing debate concerning the regulation of endocrine disruptors, has increasingly led to questions concerning the current testing of chemicals and whether this is adequate for the assessment of potential endocrine disrupting effects. This paper describes the current testing approaches for plant protection product (PPP) active substances in the European Union and the United States and how they relate to the assessment of endocrine disrupting properties for human and environmental health. This includes a discussion of whether the current testing approaches cover modalities other than the estrogen, androgen, thyroid and steroidogenesis (EATS) pathways, sensitive windows of exposure, adequate assessment of human endocrine disorders and wildlife species, and the determination of thresholds for endocrine disruption...
July 10, 2018: Toxicology Letters
Dongdong Xu, Qiaochu You, Changfeng Chi, Shengyu Luo, Hongbin Song, Bao Lou, Yutaka Takeuchi
The yellow drum (Nibea albiflora) is an economically important maricultured fish in China, but the aquaculture of this species is severely affected by overwinter mortality associated with cold stress. Characterization of the molecular mechanisms underlying the susceptibility of the yellow drum to cold might increase our understanding of how this fish adapts to environmental challenges. Here, the transcriptional response of the yellow drum to cold stress (7.5 °C) was investigated with RNA-Seq analysis. We compared brain and muscle transcriptomes among cold-tolerant (Tol) fish that survived the cold treatment, cold-sensitive (Sen) fish that were killed by the cold treatment, and control (Con) fish that were not subjected to cold...
July 7, 2018: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
Xiaoxia Bai, Lu Yan, Chenyang Ji, Quan Zhang, Xiaowu Dong, An Chen, Meirong Zhao
Computational toxicology is widely applied to screen tens and thousands of potential environmental endocrine disruptors (EDCs) for its great efficiency and rapid evaluation in recent years. Polychlorinated biphenyls (PCBs) with 209 congeners have not been comprehensively tested for their ability to interact with the thyroid receptor (TR), which is one of the most extensively studied targets related to the effects of EDCs. In this study, we aimed to determine the thyroid-disrupting mechanisms of 209 PCBs through the combination of a novel computational ternary classification model and luciferase reporter gene assay...
July 6, 2018: Chemosphere
A Ramzi, T R Gireeshkumar, K Habeeb Rahman, Mohan Manu, K K Balachandran, Jacob Chacko, N Chandramohanakumar
Phthalic acid esters (PAEs) are a group of endocrine-disrupting chemicals listed as priority pollutants by United States Environmental Protection Agency (USEPA, 2009). This study provides baseline information on seasonal distribution and contamination status of six phthalic acid esters (∑6 PAEs) in sediments of a tropical estuary (Cochin-India). In general, the sediments accumulated more PAEs during the post monsoon (mean 2325 ngg-1 ; between 1402 and 3121 ngg-1 ) and monsoon (mean 1372 ngg-1 ; between 331 and 4015 ngg-1 ) periods indicating land run off as the major transport pathway...
July 2, 2018: Chemosphere
Xian Wang, Shan Huang, Xiaocan Li, Dongrui Jiang, Hongzhen Yu, Qiang Wu, Chaobing Gao, Zhengsheng Wu
Papillary thyroid carcinoma (PTC) is the most common endocrine cancer with a significantly increase of the incidence recently. Several cytokines, such as thyroid peroxidase (TPO), cluster of differentiation 56 (CD56), Galectin-3, mesothelial cell (MC), cytokeratin 19 (CK19) and BRAF (B-raf) were recommended to be tested by immunohistochemistry (IHC) for a definitive diagnosis, but were still limited in clinical use because of their relative lower sensitivity and specificity. MicroRNA (miRNA), as a new molecular biomarkers, however, has not been reported yet so far...
2018: PloS One
Huy Q Truong, Edinson Najera, Robert Zanabria-Ortiz, Emrah Celtikci, Xicai Sun, Hamid Borghei-Razavi, Paul A Gardner, Juan C Fernandez-Miranda
OBJECTIVE The endoscopic endonasal approach has become a routine corridor to the suprasellar region. The superior hypophyseal arteries (SHAs) are intimately related to lesions in the suprasellar space, such as craniopharyngiomas and meningiomas. Here the authors investigate the surgical anatomy and variations of the SHA from the endoscopic endonasal perspective. METHODS Thirty anatomical specimens with vascular injection were used for endoscopic endonasal dissection. The number of SHAs and their origin, course, branching, anastomoses, and areas of supply were collected and analyzed...
July 13, 2018: Journal of Neurosurgery
M A Shamila, P Somasekhara Reddy
Mixed endocrine-nonendocrine neoplasms are rare tumors and pose challenges in diagnosis and management. Neurofibromatosis-1 (NF-1) patients are known to develop malignancies. Although neuroendocrine tumors and gastro-intestinal stromal tumors are seen in NF-1, its association with adenocarcinoma is rare. The existence of these three entities with NF-1 is extremely rare. NF1 patients presenting with symptoms suggestive of malignancies should alert the physician for a detailed clinical work up. Diagnosis of these malignancies often requires a meticulous histopathological and immunohistochemical examination...
July 2018: Indian Journal of Pathology & Microbiology
Daphne Fonseca, Srutimala Bhuyan, Sudha S Murthy, Vishal Rao, Chandrasekhara Rao, K V V N Raju, Challa Sundaram
Objective: The objective of this study is to retrospectively evaluate follicular variant of papillary thyroid carcinoma (FVPTC) and reclassify encapsulated FVPTC as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) according to the criteria proposed by The Endocrine Pathology Society working group in 2015 to correlate with outcome. Materials and Methods: Retrospective review of case records of all patients diagnosed as carcinoma of thyroid between 2015 and 2016 was done for the histologic subtype...
July 2018: Indian Journal of Pathology & Microbiology
B Umayal, S N Jayakody, N V Chandrasekharan, W S S Wijesundera, C N Wijeyaratne
Context: Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder affecting young women. Kisspeptins are a family of closely related peptides encoded by Kiss1 gene that controls the hypothalamic-pituitary-gonadal axis by binding to its receptor (GPR54) expressed in gonadotropin-releasing hormone (GnRH) neurons and releases GnRH. Since GnRH secretion is deregulated in PCOS, we hypothesized that dysregulated gonadotropin secretion in PCOS is reflected by kisspeptin levels. Aim: We aimed to measure serum kisspeptin levels of subjects with well-characterized PCOS versus controls and explore any correlation between kisspeptin and PCOS-related reproductive and metabolic disturbances...
July 13, 2018: Journal of Postgraduate Medicine
Kadri Altundag
No abstract text is available yet for this article.
May 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Esther Rosenkranz, Andrea Thissen, Sonja Siegel, Marc Piroth, Hans Clusmann, Judith Gebauer, Georg Brabant, Ilonka Kreitschmann-Andermahr
OBJECTIVE: Cranial irradiation for brain tumours or leukaemias has been related to cognitive, endocrine and psychosocial late effects as well as sleep disturbances and increased daytime sleepiness. Studies suggest that cranial irradiation might impact on pineal melatonin secretion. Melatonin is an important regulator in human circadian rhythms and the sleep-wake cycle. The study's objective was to investigate melatonin secretion, subjective sleep parameters and their interplay in a cohort of cranially irradiated head and brain tumour and leukaemia survivors at least 3 years after radiotherapy...
July 13, 2018: Clinical Endocrinology
Luzie Jessl, Rebecca Lenz, Fabian G Massing, Jessica Scheider, Jörg Oehlmann
Since it is known that environmental contaminants have the potential to cause endocrine disorders in humans and animals, there is an urgent need for in vivo tests to assess possible effects of these endocrine disrupting chemicals (EDCs). Although there is no standardized guideline, the avian embryo has proven to be particularly promising as it responds sensitively to a number of EDCs preferentially impacting the reproductive axis. In the present study we examined the effects of in ovo exposure to fulvestrant and tamoxifen as antiestrogenic model compounds and co-exposure to both substances and the potent estrogen 17α-ethinylestradiol (EE2 ) regarding sex differentiation and embryonic development of the domestic fowl ( Gallus gallus domesticus )...
2018: PeerJ
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