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https://www.readbyqxmd.com/read/28234024/effects-of-prenatal-exposure-to-endocrine-disruptors-and-toxic-metals-on-the-fetal-epigenome
#1
Paige A Bommarito, Elizabeth Martin, Rebecca C Fry
Exposure to environmental contaminants during pregnancy has been linked to adverse outcomes at birth and later in life. The link between prenatal exposures and latent health outcomes suggests that these exposures may result in long-term epigenetic reprogramming. Toxic metals and endocrine disruptors are two major classes of contaminants that are ubiquitously present in the environment and represent threats to human health. In this review, we present evidence that prenatal exposures to these contaminants result in fetal epigenomic changes, including altered global DNA methylation, gene-specific CpG methylation and microRNA expression...
March 2017: Epigenomics
https://www.readbyqxmd.com/read/28233726/penetrating-neck-injury-collaterals-for-another-life-after-ligation-of-common-carotid-artery-and-subclavian-artery
#2
Annu Babu, Harshit Garg, Sushma Sagar, Amit Gupta, Subodh Kumar
Neck, being not protected by skeleton, is vulnerable to external trauma and injury which involves blood vessels, trachea, esophagus and other endocrine and nervous system organs. Vascular injuries can not only cause potentially life-threatening hemorrhage but also need profound surgical expertise in management. Development of collateral circulation in neck is well known; however, there is scarcity of literature on the role of collateral formation in neck trauma. Here, we present a unique case of penetrating gunshot injury to neck with right common carotid and right subclavian artery injury with hemorrhagic shock managed with ligation of these vessels as a life-saving procedure...
September 6, 2016: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/28233694/prenatal-and-lactational-bisphenol-a-exposure-does-not-alter-serotonergic-neurons-morphologically-in-the-murine-dorsal-raphe-nucleus
#3
Shoko Goto, Hiroshi Ogi, Shinji Fushiki, Kyoko Itoh
OBJECTIVE: There is concern that bisphenol A (BPA), an endocrine-disrupting chemical, affects brain development when exposed to a fetus and/or infant. We previously reported that increased serotonin (5-HT) and its metabolite (5-HIAA) in the dorsal raphe nucleus (DRN) in murine adult brains when they were prenatally exposed to low doses of BPA. This study investigates the morphological alteration of the dorsal raphe nucleus (DRN) in order to explain the disrupted serotonergic system after prenatal and lactational exposure to bisphenol A (BPA)...
February 20, 2017: Brain & Development
https://www.readbyqxmd.com/read/28233510/endocrine-and-metabolic-aspects-of-tuberculosis
#4
Christopher Vinnard, Emily A Blumberg
Endocrine and metabolic derangements are infrequent in patients with tuberculosis, but they are important when they occur. The basis for these abnormalities is complex. While Mycobacterium tuberculosis has been described to infect virtually every endocrine gland, the incidence of gland involvement is low, especially in the era of effective antituberculosis therapy. Furthermore, endocrine and metabolic abnormalities do not always reflect direct infection of the gland but may result from physiological response or as a consequence of therapy...
January 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28233342/four-cases-of-pediatric-deep-seated-subcutaneous-pyogenic-granuloma-review-of-literature-and-differential-diagnosis
#5
Juan Putra, Beth Rymeski, A Carl Merrow, Roshni Dasgupta, Anita Gupta
BACKGROUND: Pyogenic granulomas are benign, reactive, typically superficial vascular lesions that can be idiopathic or arise secondary to trauma, underlying vascular malformations, infections, physiologic or pathologic endocrine changes, and hormone therapy. Deep-seated/subcutaneous pyogenic granulomas (DSPG) are rarely seen in any age group. Pediatric DSPGs can be a clinical and pathologic challenge because these lesions mimic other vascular lesions, including kaposiform hemangioendothelioma, infantile hemangiomas, and vascular malformations...
February 23, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28233247/the-gh-igf-1-axis-in-a-critical-period-early-in-life-determines-cellular-dna-repair-capacity-by-altering-transcriptional-regulation-of-dna-repair-related-genes-implications-for-the-developmental-origins-of-cancer
#6
Andrej Podlutsky, Marta Noa Valcarcel-Ares, Krysta Yancey, Viktorija Podlutskaya, Eszter Nagykaldi, Tripti Gautam, Richard A Miller, William E Sonntag, Anna Csiszar, Zoltan Ungvari
Experimental, clinical, and epidemiological findings support the concept of developmental origins of health and disease (DOHAD), suggesting that early-life hormonal influences during a sensitive period around adolescence have a powerful impact on cancer morbidity later in life. The endocrine changes that occur during puberty are highly conserved across mammalian species and include dramatic increases in circulating GH and IGF-1 levels. Importantly, patients with developmental IGF-1 deficiency due to GH insensitivity (Laron syndrome) do not develop cancer during aging...
February 23, 2017: Geroscience
https://www.readbyqxmd.com/read/28233015/-endocrinology-and-interdisciplinary-consultation-in-internal-medicine-illustrated-using-the-example-of-polyglandular-autoimmune-syndrome
#7
G J Kahaly, J Zimmermann, M P Hansen, F Gundling, F Popp, M Welcker
Polyglandular autoimmune syndromes encompass several endocrine and nonendocrine autoimmune disorders with variable onset and phenotype. Rheumatoid and gastroenterological symptoms in patients with autoimmune polyglandular syndromes are suggestive of additional rheumatoid gastrointestinal and hepatological autoimmune diseases. Autoimmune gastritis, celiac disease, autoimmune hepatitis, rheumatoid arthritis, Sjögren syndrome, and systemic Lupus erythematodus are of particular clinical relevance. In addition, unspecific rheumatoid and gastrointestinal attendant symptoms of the existing autoimmune endocrinopathy must be considered...
February 23, 2017: Der Internist
https://www.readbyqxmd.com/read/28232650/-novel-role-of-skeletal-muscle-in-systemic-energy-homeostasis-mechano-metabo-coupling-via-muscle-liver-fat-signaling-axis
#8
Hirotoshi Tanaka, Noriaki Shimizu
Skeletal muscle has a pleiotropic role in organismal energy metabolism, for example, by storing protein as an energy source, or by excreting endocrine hormones. Muscle proteolysis is an active process tightly controlled by specific signaling pathways and transcriptional programs, involving ubiquitin-proteasome and autophagy machineries. Glucocorticoid receptor(GR)transcriptionally controls expression levels of components in the both machineries, and modulates muscle-liver-fat signaling axis. This skeletal muscle-liver-fat signaling axis controls organismal energy distribution and may serve as a target for the development of therapies against various metabolic diseases, including obesity...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28232613/pet-imaging-for-endocrine-malignancies-from-woe-to-go
#9
David Taïeb, Rodney Hicks, Karel Pacak
No abstract text is available yet for this article.
February 23, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28232597/multidisciplinary-management-of-breast-cancer-during-pregnancy
#10
Shlomit Strulov Shachar, Kristalyn Gallagher, Kandace McGuire, Timothy M Zagar, Aimee Faso, Hyman B Muss, Raeshall Sweeting, Carey K Anders
BACKGROUND: Although breast cancer during pregnancy (BCDP) is rare (occurring with only 0.4% of all BC diagnoses in female patients aged 16-49 years), management decisions are challenging to both the patient and the multidisciplinary team. MATERIALS AND METHODS: Experts in breast cancer at the University of North Carolina conducted a targeted literature search regarding the multidisciplinary treatment approaches to BCDP: medical, surgical, and radiation oncology...
February 23, 2017: Oncologist
https://www.readbyqxmd.com/read/28232376/gangliocytoma-outcome-of-a-rare-silent-pituitary-tumour
#11
Bruno Donadille, Chiara Villa, Stephan Gaillard, Sophie Christin-Maitre
The most common finding in front of a pituitary incidentaloma is a silent pituitary adenoma. We describe a 59 years old woman with a pituitary gangliocytoma and her follow-up after 1 year. Hormonal exploration only evidenced partial corticotropic insufficiency. A trans-sphenoidal surgery was performed due to the tumour's suprasellar expansion. Gangliocytoma is a benign tumour of unknown prevalence, belonging to central nervous system tumour with neuronal differentiation, and 129 cases have been reported in the literature...
February 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28232372/late-effects-of-blood-and-marrow-transplantation
#12
Yoshihiro Inamoto, Stephanie J Lee
Hematopoietic cell transplantation is a curative treatment for a variety of hematologic diseases. Advances in transplantation technology have reduced early transplant-related mortality and expanded application of transplantation to older patients and to a wider variety of diseases. Management of late effects after transplantation is increasingly important for a growing number of long-term survivors that is estimated to be half a million worldwide. Many studies have shown that transplant survivors suffer from significant late effects that adversely affect morbidity, mortality, working status and quality of life...
February 23, 2017: Haematologica
https://www.readbyqxmd.com/read/28232301/rationale-and-design-of-a-genetic-study-on-cardiometabolic-risk-factors-protocol-for-the-tehran-cardiometabolic-genetic-study-tcgs
#13
Maryam S Daneshpour, Mohammad-Sadegh Fallah, Bahareh Sedaghati-Khayat, Kamran Guity, Davood Khalili, Mehdi Hedayati, Ahmad Ebrahimi, Farhad Hajsheikholeslami, Parvin Mirmiran, Fahimeh Ramezani Tehrani, Amir-Abbas Momenan, Arash Ghanbarian, Atieh Amouzegar, Parisa Amiri, Fereidoun Azizi
BACKGROUND: Cardiometabolic risk factors comprise cardiovascular diseases and/or diabetes, and need to be evaluated in different fields. OBJECTIVE: The primary aim of the Tehran Cardiometabolic Genetic Study (TCGS) is to create a comprehensive genome-wide database of at least 16,000 Tehranians, who are participants of the ongoing Tehran Lipid and Glucose Study (TLGS) cohort. METHODS: TCGS was designed in collaboration with the Research Institute for Endocrine Sciences and the genetic company deCODE...
February 23, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28232162/body-mass-index-and-the-risk-of-infection-from-underweight-to-obesity
#14
REVIEW
Jochen Dobner, Susanne Kaser
BACKGROUND: Nutritional status is a well-known risk factor for metabolic and endocrine disorders. Recent studies suggest that dietary intake also affects immune function and as a consequence infection risk. AIMS: This reviews aims to give an overview on the effect of body weight on infection rate in different periods of life. SOURCES: Clinically relevant prospective, cross-sectional and case-control community-based studies are summarized. CONTENT: In children and adolescents underweight is a significant risk factor of infection especially in developing countries, probably reflecting malnutrition and poor hygienic standard...
February 20, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28232102/endocrine-disruptors-data-based-survey-of-in-vivo-tests-predictive-models-and-the-adverse-outcome-pathway
#15
Romualdo Benigni, Chiara Laura Battistelli, Cecilia Bossa, Alessandro Giuliani, Olga Tcheremenskaia
The protection from endocrine disruptors is a high regulatory priority. Key issues are the characterization of in vivo assays, and the identification of reference chemicals to validate alternative methods. In this exploration, publicly available databases for in vivo assays for endocrine disruption were collected and compared: Rodent Uterotrophic, Rodent Repeated Dose 28-day Oral Toxicity, 21-Day Fish, and Daphnia magna reproduction assays. Only the Uterotrophic and 21-Day Fish assays results correlated with each other...
February 20, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28231890/-pancreatic-infringement-exocrine-and-endocrine-in-cystic-fibrosis
#16
L Kessler, M Abély
The exocrine pancreatic insufficiency affects more than 80% of cystic fibrosis (CF) infants. Pancreatic insufficiency is diagnosed by low levels of fecal elastase. An optimal caloric intake, a pancreatic enzyme treatment are the keys to maintain a good nutritional status. The fat soluble vitamins supplementation will be associated with pancreatic enzymes treatment and will be adapted to plasma levels. Iron and oligo-element deficiency such as zinc is common. The pancreatic enzymes function is not optimal in the proximal bowel: the intraluminal intestinal pH is low because of the absence of bicarbonate release by the pancreas...
December 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28231873/trends-in-analytical-methodologies-for-the-determination-of-alkylphenols-and-bisphenol-a-in-water-samples
#17
REVIEW
N Salgueiro-González, S Muniategui-Lorenzo, P López-Mahía, D Prada-Rodríguez
In the last decade, the impact of alkylphenols and bisphenol A in the aquatic environment has been widely evaluated because of their high use in industrial and household applications as well as their toxicological effects. These compounds are well-known endocrine disrupting compounds (EDCs) which can affect the hormonal system of humans and wildlife, even at low concentrations. Due to the fact that these pollutants enter into the environment through waters, and it is the most affected compartment, analytical methods which allow the determination of these compounds in aqueous samples at low levels are mandatory...
April 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28231723/risk-of-endocrine-adverse-events-in-cancer-patients-treated-with-pd-1-inhibitors-a-systematic-review-and-meta-analysis
#18
Yan Hong Shang, Yu Zhang, Jing Hua Li, Peng Li, Xi Zhang
AIM: We conducted this meta-analysis to investigate the overall incidence and risk of endocrine complications in cancer patients treated with PD-1 inhibitors. METHODS: Pubmed, Embase and oncology conference proceedings were searched for relevant studies. RESULTS: In comparison with chemotherapy or everolimus or cetuximab control, PD-1 inhibitors significantly increased the risk of all grade hypothyroidism (relative risk: 6.38; 95% CI: 3.78-10...
March 2017: Immunotherapy
https://www.readbyqxmd.com/read/28231576/molecular-markers-involved-in-tumorigenesis-of-thyroid-carcinoma-focus-on-aggressive-histotypes
#19
Gustavo C Penna, Fernanda Vaisman, Mario Vaisman, Manuel Sobrinho-Simões, Paula Soares
Thyroid cancer derived from follicular cells (TCDFC) comprises well-differentiated (papillary and follicular) carcinoma, poorly differentiated carcinoma, and anaplastic carcinoma. Papillary thyroid carcinoma is the most common endocrine cancer, and its incidence is steadily increasing. Lethality and aggressiveness of TCDFC is inversely correlated with differentiation degree. In this review, an emphasis has been put on molecular markers involved in tumorigenesis of thyroid carcinoma with a focus on aggressive histotypes and the role of such biomarkers in predicting thyroid cancer outcome...
February 24, 2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/28231547/nonmonotonic-responses-to-low-doses-of-xenoestrogens-a-review
#20
REVIEW
Zhixiang Xu, Jun Liu, Xinhao Wu, Bin Huang, Xuejun Pan
Xenoestrogens (XEs) mimic or block the synthesis, metabolism and transport of normal endogenous hormones, disturbing normal endocrine function. The available data on the nonmonotonic estrogenic effects of low doses of many XEs are reviewed, covering in vitro, in vivo and epidemiological studies. The observed nonmonotonic patterns of the dose-response curves are discussed, along with possible underlying mechanisms. This review is intended to provide guidance for harm predication and to suggest prevention measures...
February 20, 2017: Environmental Research
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