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Cystitis C

Ines Ambite, Manoj Puthia, Karoly Nagy, Caterina Cafaro, Aftab Nadeem, Daniel S C Butler, Gustav Rydström, Nina A Filenko, Björn Wullt, Thomas Miethke, Catharina Svanborg
The clinical studies were approved by the Human Ethics Committee at Lund University (approval numbers LU106-02, LU236-99 and Clinical Trial Registration RTP-A2003, International Committee of Medical Journal Editors,
October 2016: PLoS Pathogens
Véronique Livet, Paul Pillard, Isabelle Goy-Thollot, David Maleca, Quentin Cabon, Denise Remy, Didier Fau, Éric Viguier, Céline Pouzot, Claude Carozzo, Thibaut Cachon
OBJECTIVES: The purpose of this study was to describe the perioperative and postoperative complications as well as short-term and long-term outcomes in cats with ureteral obstructions treated by placement of a subcutaneous ureteral bypass (SUB) device without imaging control. The second objective of this study was to compare cats treated by SUB device with cats treated by traditional surgical intervention. METHODS: Data were obtained retrospectively from the medical records (2014-2016) of cats that underwent SUB placement (SUB cats) and cats that underwent traditional ureteral surgery (C cats)...
September 30, 2016: Journal of Feline Medicine and Surgery
J C Rosa-E-Silva, C Pazin, Apm Silva, A M Mitidieri, M B Gurian
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
C Duployez, C Loiez, C Cattoen, D Descamps, F Wallet, A Vachée
OBJECTIVES: Pivmecillinam is a safe beta-lactam for use in pregnancy. It has been widely used for the treatment of lower urinary tract infections (UTIs) in the Nordic countries where its efficacy, minor impact on the microbiota, and low level of resistance among the Escherichia coli strains have been proven. However, susceptibility data related to E. coli involved in asymptomatic bacteriuria and lower UTIs in pregnant women is lacking. We aimed to support the 2015 recommendations issued by the French Infectious Diseases Society (SPILF) on gestational UTI, with a particular focus on pivmecillinam...
September 5, 2016: Médecine et Maladies Infectieuses
I García-Cadenas, I Rivera, R Martino, A Esquirol, P Barba, S Novelli, G Orti, J Briones, S Brunet, D Valcarcel, J Sierra
This study aimed to characterize the incidence, etiology and outcome of infectious episodes in patients with steroid refractory acute GvHD (SR-GvHD). The cohort included 127 adults treated with inolimomab (77%) or etanercept (23%) owing to acute 2-4 SR-GvHD, with a response rate of 43% on day +30 and a 4-year survival of 15%. The 1-year cumulative incidences of bacterial, CMV and invasive fungal infection were 74%, 65% and 14%, respectively. A high rate (37%) of enterococcal infections was observed. Twenty patients (15...
September 5, 2016: Bone Marrow Transplantation
Gregory Kanter, Katherine A Volpe, Gena C Dunivan, Sara B Cichowski, Peter C Jeppson, Rebecca G Rogers, Yuko M Komesu
INTRODUCTION: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a poorly understood source of chronic pain causing significant morbidity, with variable treatment success. Despite the need to understand patient perspectives in chronic pain, there is a paucity of qualitative data for IC/BPS. We aimed to acquire information regarding patient experience with IC/BPS symptoms and with their medical care to elicit suggestions to improve patient satisfaction with that care. METHODS: Fifteen women with IC/PBS participated in a total of four focus groups...
August 31, 2016: International Urogynecology Journal
Prashant R Gore, Chaitali P Prajapati, Umesh B Mahajan, Sameer N Goyal, Sateesh Belemkar, Shreesh Ojha, Chandragouda R Patil
Cyclophosphamide (CYP) induced hemorrhagic cystitis is a dose-limiting side effect involving increased oxidative stress, inflammatory cytokines and suppressed activity of nuclear factor related erythroid 2-related factor (Nrf2). Thymoquinone (TQ), an active constituent of Nigella sativa seeds, is reported to increase the expression of Nrf2, exert antioxidant action, and anti-inflammatory effects in the experimental animals. The present study was designed to explore the effects of TQ on CYP-induced hemorrhagic cystitis in Balb/c mice...
2016: International Journal of Biological Sciences
Cheng-Huang Shen, Shou-Chieh Wang, Shou-Tsung Wang, Shu-Mei Lin, Jiann-Der Wu, Chang-Te Lin, Yi-Wen Liu
Long-term ketamine abuse has been shown to affect the lower urinary tract and result in interstitial cystitis-like syndrome. However, the causative mechanism of ketamine-induced dysfunction remains unclear. The present study aimed to investigate the physiological, histological and molecular changes on ketamine‑associated cystitis (KC) in a mouse model. Both male and female Balb/c mice were separately distributed into the control group (normal saline) and ketamine group, which received ketamine hydrochloride (100 mg/kg/day) daily by intraperitoneal injection for a total period of 20 weeks...
September 2016: Molecular Medicine Reports
A Rimondo, R Crocchiolo, J El-Cheikh, S Bramanti, A Granata, S Furst, B Sarina, L Morabito, R Devillier, S Harbi, B Mohty, R Mineri, C Faucher, C Chabannon, A Santoro, D Blaise, L Castagna
No abstract text is available yet for this article.
July 18, 2016: Bone Marrow Transplantation
L Domenici, M Monti, C Bracchi, M Giorgini, V Colagiovanni, L Muzii, P Benedetti Panici
OBJECTIVE: Urinary tract infections still represent a significant bother for women and result in high costs to the health system. D-mannose is a simple sugar; it seems able to hinder bacteria adhesion to the urothelium. The present study aimed to determine whether D-mannose alone is effective in treating acute urinary tract infections in women and its possible utility in the management of recurrences. PATIENTS AND METHODS: This is a pilot study, performed between April 2014 and July 2015 at Department of Gynaecological Obstetrics and Urologic Sciences of "Sapienza" University of Rome...
July 2016: European Review for Medical and Pharmacological Sciences
Sophie Y Leclercq, Matthew J Sullivan, Deepak S Ipe, Joshua P Smith, Allan W Cripps, Glen C Ulett
Streptococcus agalactiae can cause urinary tract infection (UTI) including cystitis and asymptomatic bacteriuria (ABU). The early host-pathogen interactions that occur during S. agalactiae UTI and subsequent mechanisms of disease pathogenesis are poorly defined. Here, we define the early interactions between human bladder urothelial cells, monocyte-derived macrophages, and mouse bladder using uropathogenic S. agalactiae (UPSA) 807 and ABU-causing S. agalactiae (ABSA) 834 strains. UPSA 807 adhered, invaded and killed bladder urothelial cells more efficiently compared to ABSA 834 via mechanisms including low-level caspase-3 activation, and cytolysis, according to lactate dehydrogenase release measures and cell viability...
2016: Scientific Reports
Natalie J Gauld, C McGuinness, Irene Sl Zeng, Rosemary B Ikram, Mark G Thomas, Stephen A Buetow
AIMS: To describe prescribing for women with suspected urinary tract infections, including suspected uncomplicated cystitis, in New Zealand. METHODS: Randomly selected community pharmacies participated in the study. Women attending the pharmacy in a 2-week period in 2012 for prescribed or non-prescription treatment of symptoms suggesting a urinary tract infection, or prophylaxis of a urinary tract infection, were invited to self-complete a questionnaire. Analysis focused on prescribing for women with symptoms of cystitis without complicating features...
2016: New Zealand Medical Journal
Lana Sundac, Samantha J Dando, Matthew J Sullivan, Petra Derrington, John Gerrard, Glen C Ulett
Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are common infections in humans. Despite the substantial healthcare cost represented by these infections, the human immune response associated with the infection immediately following the onset of symptoms in patients remains largely undefined. We performed a prospective study aimed at defining the milieu of urinary cytokines in adult inpatients in the 24-48 h period immediately following hospital admission for acute cystitis due to UPEC...
August 2016: Pathogens and Disease
S Espenel, C Raffoux, A Vallard, M-A Garcia, J-B Guy, C Rancoule, M Ben Mrad, J Langrand-Escure, J-C Trone, G Pigne, P Diao, N Magné
Worldwide, more than a million people receive each year a curative radiotherapy. While local control and overall survival are steadily increasing, 5 to 15% of patients still develop above grade 2 late toxicities. Late toxicities treatments are complex. Hyperbaric oxygenation was shown to induce revascularization and healing of injured tissues, but indications are still debated. Through a literature review, we summarized the hyperbaric oxygenation indications in radiation-induced late toxicities. We also studied the knowledge and practice of French local radiation therapists...
July 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Jonathan D Tward, Stephanie Jarosek, Haitao Chu, Cameron Thorpe, Dennis C Shrieve, Sean Elliott
PURPOSE: Severe urinary adverse events (UAEs) include surgical treatment of urethral stricture, urinary incontinence, and radiation cystitis. We compared the incidence of grade 3 UAEs, according to the Common Terminology Criteria for Adverse Events, after low-dose-rate (LDR) and high-dose-rate (HDR) brachytherapy, as well as after LDR plus external beam radiation therapy (EBRT) and HDR plus EBRT. METHODS AND MATERIALS: Men aged >65 years with nonmetastatic prostate cancer were identified from the Surveillance, Epidemiology, and End Results-Medicare database who were treated with LDR (n=12,801), HDR (n=685), LDR plus EBRT (n=8518), or HDR plus EBRT (n=2392)...
August 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Massimo Tonolini, Sonia Ippolito
Complicated urinary tract infections (C-UTIs) are those associated with structural or functional genitourinary abnormalities or with conditions that impair the host defence mechanisms, leading to an increased risk of acquiring infection or failing therapy. C-UTIs occur in patients with risk factors such as neurogenic dysfunction, bladder outlet obstruction, obstructive uropathy, bladder catheterisation, urologic instrumentation or indwelling stent, urinary tract post-surgical modifications, chemotherapy- or radiation-induced damage, renal impairment, diabetes and immunodeficiency...
October 2016: Insights Into Imaging
Supram Hosuru Subramanya, Deependra Hamal, Niranjan Nayak, Shishir Gokhale
Candida parapsilosis is emerging as a potential pathogen for onychomycosis. A 4-year-old male child with perimembranous ventricular septal defect (VSD) was admitted with features of cystitis and was treated with broad spectrum antibiotics. Two weeks later, he developed yellowish discoloration of nails of both hands. The sloughed out nail, on microscopy, showed numerous yeast forms that were identified as Candida parapsilosis by both phenotypic and genotypic methods. Antifungal sensitivity testing of the isolate was performed by microbroth dilution method in accordance with CLSI guidelines...
2016: Case Reports in Pediatrics
A Braundmeier-Fleming, Nathan T Russell, Wenbin Yang, Megan Y Nas, Ryan E Yaggie, Matthew Berry, Laurie Bachrach, Sarah C Flury, Darlene S Marko, Colleen B Bushell, Michael E Welge, Bryan A White, Anthony J Schaeffer, David J Klumpp
Interstitial cystitis/bladder pain syndrome (IC) is associated with significant morbidity, yet underlying mechanisms and diagnostic biomarkers remain unknown. Pelvic organs exhibit neural crosstalk by convergence of visceral sensory pathways, and rodent studies demonstrate distinct bacterial pain phenotypes, suggesting that the microbiome modulates pelvic pain in IC. Stool samples were obtained from female IC patients and healthy controls, and symptom severity was determined by questionnaire. Operational taxonomic units (OTUs) were identified by16S rDNA sequence analysis...
2016: Scientific Reports
C Di Capua-Sacoto, A Sanchez-Llopis, E O'Connor, A Martinez, J L Ruiz-Cerdá
INTRODUCTION: The main objective of the study was to assess the apoptotic effect of urine from patients with interstitial cystitis (IC) in cell cultures and to study its value as a diagnostic biomarker for IC. MATERIAL AND METHODS: A prospective study was conducted between January 2010 and January 2015 and included 57 patients diagnosed with IC and 50 healthy patients from the Hospital Clinic of Barcelona and the La Paz University Hospital. The urine of these patients was exposed to cell cultures, and its ability to induce apoptosis in the cultures was analysed...
May 9, 2016: Actas Urologicas Españolas
Mariana G de Oliveira, Fabiano B Calmasini, Eduardo C Alexandre, Gilberto De Nucci, Fabíola Z Mónica, Edson Antunes
Activators of soluble guanylyl cyclase (sGC) interact directly with its prosthetic heme group, enhancing the enzyme responsiveness in pathological conditions. This study aimed to evaluate the effects of the sGC activator BAY 58-2667 on voiding dysfunction, protein expressions of α1 and β1 sGC subunits and cGMP levels in the bladder tissues after cyclophosphamide (CYP) exposure. Female C57BL/6 mice (20-25 g) were injected with CYP (300 mg/kg ip) to induce cystitis. Mice were pretreated or not with BAY 58-2667 (1 mg/kg, gavage), given 1 h before CYP injection...
July 1, 2016: American Journal of Physiology. Renal Physiology
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