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https://www.readbyqxmd.com/read/29464752/voluntary-wheel-running-attenuates-urinary-bladder-hypersensitivity-and-dysfunction-following-neonatal-maternal-separation-in-female-mice
#1
Angela N Pierce, Olivia C Eller-Smith, Julie A Christianson
AIMS: Patients with interstitial cystitis/painful bladder syndrome (IC/PBS) commonly suffer from widespread pain and mood disorder, which has been attributed to improper functioning of the hypothalamic-pituitary-adrenal (HPA) axis. Voluntary exercise has been shown to improve HPA axis function, therefore we are determining whether voluntary wheel running can attenuate urological pain and dysfunction following neonatal maternal separation (NMS) in female mice. METHODS: Mice underwent NMS for 3 h/day from postnatal Day 1-21, were caged with free access to running wheels at 4 weeks of age, and assessed 4 weeks later for bladder sensitivity, micturition, reward behavior, mast cell degranulation, and HPA axis-related in vitro analysis...
February 21, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29460790/protein-and-micronutrient-deficiencies-in-patients-with-radiation-cystitis-and-outcome-after-hyperbaric-oxygen-therapy
#2
Valérie Platzer, Guillaume Perez, Anne Galinier, Michèle Genestal, Béatrice Riu-Poulenc, Leslie Gonzalez, Eric Huyghe, Sylvie Caspar-Bauguil
BACKGROUND & AIMS: Haemorrhagic radiation cystitis (HRC) is a late complication of pelvic radiotherapy. Severe cases are difficult to treat due to persistent or recurrent bleeding, despite urological and hyperbaric oxygen therapy (HBOT). However, wound healing requires a good nutritional status. In this respect, we aimed at analysing the nutritional status of patients with HRC prior to the onset of HBOT and at highlighting predictive nutritional factors of outcome. METHODS: Data were retrospectively collected from a cohort of 179 patients with HRC (between 2011 and 2015)...
February 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29417760/fosfomycin-as-a-potential-therapy-for-the-treatment-of-systemic-infections-a-population-pharmacokinetic-model-to-simulate-multiple-dosing-regimens
#3
Natalia V Ortiz Zacarías, Anneke C Dijkmans, Jacobus Burggraaf, Johan W Mouton, Erik B Wilms, Cees van Nieuwkoop, Daan J Touw, Ingrid M C Kamerling, Jasper Stevens
Fosfomycin has emerged as a potential therapy for multidrug-resistant bacterial infections. In most European countries, the oral formulation is only approved as a 3 g single dose for treatment of uncomplicated cystitis. However, for the treatment of complicated systemic infections, this dose regimen is unlikely to reach efficacious serum and tissue concentrations. This study aims to investigate different fosfomycin-dosing regimens to evaluate its rationale for treatment of systemic infections. Serum concentration-time profiles of fosfomycin were simulated using a population pharmacokinetic model based on published pharmacokinetic parameter values, their uncertainty, inter-individual variability and covariates...
February 2018: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/29402306/sustainable-reduction-of-antibiotic-induced-antimicrobial-resistance-arena-in-german-ambulatory-care-study-protocol-of-a-cluster-randomised-trial
#4
Martina Kamradt, Petra Kaufmann-Kolle, Edith Andres, Tonia Brand, Anja Klingenberg, Katharina Glassen, Regina Poß-Doering, Lorenz Uhlmann, Katharina Hees, Dorothea Weber, Andreas Gutscher, Veit Wambach, Joachim Szecsenyi, Michel Wensing
BACKGROUND: Despite many initiatives to enhance the rational use of antibiotics, there remains substantial room for improvement. The overall aim of this study is to optimise the appropriate use of antibiotics in German ambulatory care in patients with acute non-complicated infections (respiratory tract infections, such as bronchitis, sinusitis, tonsillitis and otitis media), community-acquired pneumonia and non-complicated cystitis, in order to counter the advancing antimicrobial resistance development...
February 5, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29394134/chronic-cystitis-associated-with-plesiochorus-cymbiformis-rudolphi-1819-looss-1901-digenea-gorgoderidae-in-a-loggerhead-turtle-caretta-caretta-linnaeus-1758-testudines-cheloniidae-from-brazil
#5
Max Rondon Werneck, Adriana Mastrangelli, Renato Velloso, Hassan Jerdy, Eulógio C Q Carvalho
This paper reports the first discovery of Plesiochorus cymbiformis (Digenea: Gorgoderidae) from a loggerhead turtle [Caretta caretta (Testudines, Cheloniidae)] in Brazil and describes the histological findings of related injuries to the urinary bladder.
February 2, 2018: Journal of Parasitology
https://www.readbyqxmd.com/read/29358784/-uncomplicated-urinary-tract-infections-antimicrobial-susceptibility-study-in-navarre
#6
A Aguinaga, A Gil-Setas, A Mazón Ramos, A Alvaro, J J García-Irure, A Navascués, C Ezpeleta Baquedano
BACKGROUND: Urinary tract infection (UTI) is a high prevalence infection at the community level. In order to improve the adequacy of the empirical therapy, we evaluated the etiology and the resistance pattern of the main uropathogens responsible for community acquired UTI in Navarre. METHODS: Retrospective study (2014-2016) in which we included microorganisms recovered with significant counts from samples of patients with community-acquired UTI. The global etiology and etiology according to age and sex was analyzed...
January 23, 2018: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/29288643/a-case-crossover-study-of-urologic-chronic-pelvic-pain-syndrome-flare-triggers-in-the-mapp-research-network
#7
Siobhan Sutcliffe, Thomas Jemielita, H Henry Lai, Gerald L Andriole, Catherine S Bradley, J Quentin Clemens, Robert Gallop, Thomas M Hooton, Karl J Kreder, John N Krieger, John W Kusek, Jennifer Labus, M Scott Lucia, Sean Mackey, Bruce D Naliboff, Nancy A Robinson, Larissa V Rodriguez, Alisa Stephens-Shields, Adrie van Bokhoven, Kathleen Y Wolin, Yan Yan, Claire C Yang, J Richard Landis, Graham A Colditz
PURPOSE: Although many factors have been proposed to trigger symptom exacerbations ("flares") in patients with interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome, few studies have investigated these factors empirically. Therefore, we embedded a case-crossover study in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain longitudinal study to evaluate a range of patient-reported triggers. MATERIALS AND METHODS: Exposure to proposed triggers (diet, physical activities, sedentary behaviors, stress, sexual activities, infection-like symptoms, and allergies) was assessed by questionnaire a maximum of three times when participants reported flares and at three randomly-selected times...
December 27, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29277656/unmasking-of-urinary-pubic-symphysis-fistula-upf-after-implantation-of-artificial-urinary-sphincter-in-prostate-cancer-survivors-user-beware-url-d-17-02187
#8
Arman A Kahokehr, Andrew C Peterson
OBJECTIVE: To describe the dramatic and rapid unmaking of Urinary pubic symphysis fistula and chronic osteomyelitis (UPF) following artificial urinary sphincter implantation (AUS). This has never been reported as UPF is usually an insidious sequelae of radiotherapy/energy ablation for prostate cancer (PCa). METHODS: We prospectively identified men who underwent rapid clinical decline due to UPF soon after AUS implantation at our institution in the previous 24 months...
December 22, 2017: Urology
https://www.readbyqxmd.com/read/29249972/pathophysiological-role-of-transient-receptor-potential-ankyrin-1-in-a-mouse-long-lasting-cystitis-model-induced-by-an-intravesical-injection-of-hydrogen-peroxide
#9
Shohei Oyama, Koji Dogishi, Mizuki Kodera, Masashi Kakae, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko
Chronic inflammatory bladder disorders, such as interstitial cystitis/bladder pain syndrome, are associated with poor quality of life. The exact pathological processes remain unclear, but accumulating evidence suggests that reactive oxidative species (ROS) are involved in urinary bladder disorders. Transient receptor potential ankyrin 1 (TRPA1), the most sensitive TRP channel to ROS, was shown to be responsible for urinary bladder abnormalities and hyperalgesia in an acute cystitis model. However, the roles of TRPA1 in chronic inflammatory bladder are not fully understood...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29226304/successful-medical-management-of-pseudomembranous-cystitis-in-three-cats-with-lower-urinary-tract-obstruction
#10
A Vila, R Movilla, J Castro, C Mallol, R Novellas, Y Espada, X Roura
CASE REPORT: The present case series describes the clinical course and outcome of three cats diagnosed with pseudomembranous cystitis. This is an uncommon presentation of lower urinary tract obstruction but can be easily be identified by ultrasonography, revealing severe bladder wall thickening and thin hyperechoic luminal strips. The condition can be secondary to severe bacterial urinary tract infection. All cats were successfully treated with medical management only, mainly based on antimicrobials and individualised supportive therapy...
December 10, 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/29198679/treatment-of-a-pediatric-case-of-severe-hemorrhagic-cystitis-case-report-and-review-of-literature
#11
L Yang, Y Zha, J Feng, H Dong, C Zong, X Lei, N Liang, X Wang, G Gao, X Bai
Hemorrhagic cystitis is one of the complications of allogeneic hematopoietic stem cell transplantation. Treatment of hemorrhagic cystitis is difficult, especially in pediatric patients. A pediatric case of severe hemorrhagic cystitis after hematopoietic stem cell transplantation was treated in our hospital with arterial embolization combined with corticosteroid therapy because the conventional therapy was invalid for him. After the treatment, hemorrhagic cystitis was cured. During follow-up, the patient was in stable condition, with normal urine, blood cells returned to normal, bone marrow was in complete remission state, and disease-free survival for more than 8 months...
December 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29169704/cumulative-incidence-and-predictive-factors-of-radiation-cystitis-in-patients-with-localized-prostate-cancer
#12
D Afonso-João, L Pacheco-Figueiredo, T Antunes-Lopes, L A Morgado, V Azevedo, L Vendeira, J Silva, C Martins-Silva
PURPOSE: To determine the cumulative incidence of overall and severe radiation cystitis in a high volume cohort of patients and to investigate its potential predictive factors. METHODS: We have performed a retrospective analysis of clinical data from patients diagnosed with localized prostate cancer and treated with radiotherapy at our institution (June 2005-January 2013), and quantified the cumulative incidence of radiation cystitis. Cox regression analysis and Kaplan-Meier curves were computed to evaluate the determinants of radiation cystitis...
November 20, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29132932/apoptotic-effect-as-biomarker-of-disease-severity-and-follow-up-in-interstitial-cystitis
#13
C Di Capua-Sacoto, A Sanchez-Llopis, J E Oconnor, A Martinez-Romero, J L Ruiz-Cerdá
OBJECTIVE: To determine whether the apoptotic effect test could serve as a biomarker of severity in bladder pain syndrome/interstitial cystitis. MATERIAL AND METHODS: A prospective study was conducted between January 2010 and January 2015, which included 57 patients diagnosed with interstitial cystitis and 49 diagnosed with chronic pelvic pain of gynaecological origin. The urine was exposed to cell cultures, and the urine's capacity for inducing apoptosis in the cultures was analysed...
November 10, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29118019/acyloxyacyl-hydrolase-modulates-pelvic-pain-severity
#14
Wenbin Yang, Ryan E Yaggie, Mingchen C Jiang, Charles N Rudick, Joseph D Done, Charles J Heckman, John M Rosen, Anthony J Schaeffer, David J Klumpp
Chronic pelvic pain causes significant patient morbidity and is a bane to clinicians. Using a murine neurogenic cystitis model that recapitulates key aspects of interstitial cystitis/bladder pain syndrome (IC), we recently showed that pseudorabies virus (PRV) induces severe pelvic allodynia in BALB/c mice, relative to C57BL/6 mice. Here, we report that a quantitative trait locus (QTL) analysis of PRV-induced allodynia in F2CxB progeny identified a polymorphism on chromosome 13, rs6314295, significantly associated with allodynia (LOD=3...
November 8, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29101714/changes-in-healthcare-spending-after-diagnosis-of-comorbidities-among-endometriosis-patients-a-difference-in-differences-analysis
#15
Andrew J Epstein, Ahmed M Soliman, Matthew Davis, Scott J Johnson, Michael C Snabes, Eric S Surrey
INTRODUCTION: We sought to characterize changes in healthcare spending associated with the onset of 22 endometriosis-related comorbidities. METHODS: Women aged 18-49 years with endometriosis (N = 180,278) were extracted from 2006-2015 de-identified Clinformatics(®) DataMart claims data. For 22 comorbidities, comorbidity patients were identified on the basis of having a first comorbidity diagnosis after their initial endometriosis diagnosis. Controls were identified on the basis of having no comorbidity diagnosis and were matched 1:1 to comorbidity patients on demographics and baseline spending...
November 3, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/29078739/effects-of-a-new%C3%A2-combination-of%C3%A2-plant-extracts-plus-d-mannose-for-the-management-of-uncomplicated-recurrent-urinary-tract-infections
#16
Carlo Genovese, Sergio Davinelli, Katia Mangano, Gianna Tempera, Daria Nicolosi, Salvatore Corsello, Franca Vergalito, Edoardo Tartaglia, Giovanni Scapagnini, Roberto Di Marco
Urinary tract infections (UTIs) are an economic burden for public health. The increasing prevalence of resistant bacteria which cause UTIs may be related to the inappropriate prescription of antibiotics. The aim of this preliminary study was to evaluate whether three different combinations of plant extracts plus d-mannose are effective in preventing the recurrence of UTIs. Three groups of patients received three combinations of plant extracts in conjunction with d-mannose. These were: berberine, arbutin and birch (group A); berberine, arbutin, birch and forskolin (group B); and proanthocyanidins (group C)...
October 27, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29072568/eosinophilic-cystitis-presenting-as-a-bladder-mass-in-an-11-year-old-girl
#17
Elsa Bey, Youssef Teklali, Pierre-Yves Rabattu, Simon Grandjean Lapierre, C Piolat
No abstract text is available yet for this article.
November 11, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29057994/effects-of-herpes-simplex-virus-vectors-encoding-poreless-trpv1-or-protein-phosphatase-1%C3%AE-in-a-rat-cystitis-model-induced-by-hydrogen-peroxide
#18
S Takai, T Majima, B Reinhart, W F Goins, Y Funahashi, M Gotoh, P Tyagi, J C Glorioso, N Yoshimura
Enhanced afferent excitability is considered to be an important pathophysiological basis of interstitial cystitis/bladder pain syndrome (IC/BPS). In addition, transient receptor potential vanilloid-1 (TRPV1) receptors are known to be involved in afferent sensitization. Animals with hydrogen peroxide (HP)-induced cystitis have been used as a model exhibiting pathologic characteristics of chronic inflammatory condition of the bladder. This study investigated the effect of gene therapy with replication-defective herpes simplex virus (HSV) vectors encoding poreless TRPV1 (PL) or protein phosphatase 1 α (PP1α), a negative regulator of TRPV1, using a HP-induced rat model of cystitis...
January 2018: Gene Therapy
https://www.readbyqxmd.com/read/29048491/simultaneous-quantification-of-eight-marker-compounds-in-yongdamsagan-tang-using-a-high-performance-liquid-chromatography-equipped-with-photodiode-array-detector
#19
Chang-Seob Seo, Hyeun-Kyoo Shin
Yongdamsagan-tang (YDSGT) has been used clinically for the treatment of acute- and chronic-urethritis, cystitis, orchitis and hypertension in Korea. In this study, a powerful method based on high-performance liquid chromatography (HPLC) with photodiode array (PDA) detection was established and validated for the quantitative analysis of eight components: chlorogenic acid, gentiopicroside, liquiritin apioside, liquiritin, nodakenin, baicalin, wogonoside and glycyrrhizin in YDSGT extract. The compounds were separated with a Gemini C18 analytical column (column temperature: 40°C; mobile phase: 0...
October 1, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29038902/-urinary-tract-infections-what-has-been-confirmed-in-therapy
#20
REVIEW
J Marcon, C G Stief, G Magistro
Urinary tract infections (UTIs) affect approximately 150 million people worldwide per year, causing annual health costs of over three billion dollars just in the USA. Every second woman experiences at least one UTI in her lifetime, with every one in four experiencing recurrence. Uncomplicated infections like single or recurrent cystitis and pyelonephritis can be distinguished from complicated disease. UTIs in men can spread to the male glands, causing prostatitis and epididymitis. Antibiotic therapy is the standard procedure for UTIs...
December 2017: Der Internist
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