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https://www.readbyqxmd.com/read/28105664/visceral-and-somatic-pain-modalities-reveal-nav-1-7-independent-visceral-nociceptive-pathways
#1
James R F Hockley, Rafael González-Cano, Sheridan McMurray, Miguel A Tejada-Giraldez, Cian McGuire, Antonio Torres, Anna L Wilbrey, Vincent Cibert-Goton, Francisco R Nieto, Thomas Pitcher, Charles H Knowles, José Manuel Baeyens, John N Wood, Wendy J Winchester, David C Bulmer, Cruz Miguel Cendán, Gordon McMurray
Voltage-gated sodium channel NaV 1.7 is required for acute and inflammatory pain in mice and humans but its significance for visceral pain is unknown. Here we examine the role of NaV 1.7 in visceral pain processing and the development of referred hyperalgesia using a conditional nociceptor-specific NaV 1.7 knockout mouse (NaV 1.7(Nav1.8) ) and selective small-molecule NaV 1.7 antagonist PF-5198007. NaV 1.7(Nav1.8) mice showed normal nociceptive behaviours to intracolonic application of either capsaicin or mustard oil, stimuli known to evoke sustained nociceptor activity and sensitization following tissue damage, respectively...
January 20, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28096911/depression-and-catastrophizing-predict-suicidal-ideation-in-tertiary-care-patients-with-interstitial-cystitis-bladder-pain-syndrome
#2
Dean A Tripp, J Curtis Nickel, Adrijana Krsmanovic, Michel Pontari, Robert Moldwin, Robert Mayer, Lesley K Carr, Claire C Yang, Jorgen Nordling
INTRODUCTION: We sought to evaluate psychosocial factors as predictors of suicidal ideation (SI) in a tertiary care outpatient sample of women suffering from interstitial cystitis/bladder pain syndrome (IC/BPS). METHODS: The patients are women managed at tertiary care centres (n=190). Controls were recruited from the community (n=117). Both groups completed questionnaires on demographics, pain (McGill Pain Questionnaire), IC/BPS symptoms, and psychological variables...
November 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28093307/the-impact-of-baseline-functional-bladder-capacity-on-short-term-neuromodulation-outcomes
#3
Kim A Killinger, Priyanka Gupta, Jason P Gilleran, Jamie Bartley, Michael Ehlert, Judith A Boura, Kenneth M Peters
OBJECTIVES: To evaluate the impact of functional bladder capacity (FBC) on clinical outcomes after a staged neuromodulation procedure. METHODS: Adults in our prospective neuromodulation database were evaluated. Data were collected from medical records, voiding diaries (FBC defined as average volume per void), Interstitial Cystitis Symptom/Problem Indices (ICSI-PI), Overactive Bladder Questionnaires (OAB-q), and Global Response Assessments over 3 months. Descriptive statistics, Pearson's Chi-square tests, Wilcoxon rank sum tests, logistic regression, repeated measures analyses and Spearman Correlation Coefficients were performed...
January 13, 2017: Urology
https://www.readbyqxmd.com/read/28052786/preferential-use-of-nitrofurantoin-over-fluoroquinolones-for-acute-uncomplicated-cystitis-and-outpatient-escherichia-coli-resistance-in-an-integrated-healthcare-system
#4
Rebecca L Pedela, Katherine C Shihadeh, Bryan C Knepper, Michelle K Haas, William J Burman, Timothy C Jenkins
OBJECTIVES To evaluate changes in outpatient fluoroquinolone (FQ) and nitrofurantoin (NFT) use and resistance among E. coli isolates after a change in institutional guidance to use NFT over FQs for acute uncomplicated cystitis. DESIGN Retrospective preintervention-postintervention study. SETTING Urban, integrated healthcare system. PATIENTS Adult outpatients treated for acute cystitis. METHODS We compared 2 time periods: January 2003-June 2007 when FQs were recommended as first-line therapy, and July 2007-December 2012, when NFT was recommended...
January 5, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28048092/su-g-iep1-10-permeability-evaluation-of-interstitial-cystitis-by-dce-mri-of-the-bladder
#5
D Wu, J Vo, J North, R Towner, R Hurst
PURPOSE: Interstitial cystitis (IC) is a chronic and painful condition that can lead to bladder pain syndrome (BPS) in women. IC and BPS have been known to manifest after physiological changes after giving birth. In this project, we pioneered and advanced a new clinical utility using DCE-MRI to assess bladder permeability. At first IC/BPS perfusion methods were with ratio signal evaluation, we now incorporate pharmacokinetics techniques to allow for further assessment. METHODS: In this pilot study, female patients and volunteers (IC=4, Control=3) underwent imaging with a clinical GE 3T 750W MRI system...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043762/the-comeback-of-trimethoprim-in-france
#6
REVIEW
F Caron, V Wehrle, M Etienne
Already used in various countries, trimethoprim (TMP) was withdrawn from the French market in 1990, but should be soon available again. This article reviews the experience of TMP use around the world and its current use in Europe. Label use and guidelines only recommend the use of TMP for the treatment of urinary tract infections (UTI). Compared with co-trimoxazole (Co-T), a combination of TMP and sulfamethoxazole (SMX), TMP has (a) a similar resistance rate among Escherichia coli strains (estimated between 10 and 20% in uncomplicated cystitis), (b) a similar clinical efficacy for cystitis prevention and treatment, (c) a lower toxicity (as severe toxicity adverse effects of Co-T come from its sulfonamide component), (d) limited data for the treatment of pyelonephritis and male UTIs, and (e) an important impact on the microbiota...
December 30, 2016: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/28031194/azithromycin-ciprofloxacin-impregnated-urinary-catheters-avert-bacterial-colonization-biofilm-formation-and-inflammation-in-a-murine-model-of-foreign-body-associated-urinary-tract-infections-caused-by-pseudomonas-aeruginosa
#7
Hina Saini, Anitha Vadekeetil, Sanjay Chhibber, Kusum Harjai
Pseudomonas aeruginosa is a multifaceted pathogen causing a variety of biofilm-mediated infections including catheter-associated urinary tract infections (CAUTIs). High prevalence of CAUTIs in hospitals, their clinical manifestations like urethritis, cystitis, pyelonephritis, meningitis, urosepsis, death; and economic challenges underscore the need for management of these infections. Biomaterial modification of urinary catheters with dual drugs seems an interesting approach to combat CAUTIs by inhibiting biofilm...
December 28, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27992393/manipulating-the-extracellular-matrix-an-animal-model-of-the-bladder-pain-syndrome
#8
Ifeoma Offiah, Athanasios Didangelos, Barry A OʼReilly, Stephen B McMahon
Bladder pain syndrome (BPS) is associated with breakdown of the protective uroepithelial barrier of the urinary bladder allowing urinary constituents access to bladder sensory neurons. Although there are several animal models of cystitis, none specifically relates to BPS. Here, we aimed to create such a model using enzymatic digestion of the barrier proteoglycans (PGs) in the rat. Twenty female Wistar rats were anaesthetized and transurethrally catheterized. Ten animals were treated with 0.25IU of intravesical chondroitinase ABC and heparanase III to digest chondroitin sulphate and heparin sulphate PGs, respectively...
January 2017: Pain
https://www.readbyqxmd.com/read/27930554/pulsed-radiofrequency-treatment-of-the-superior-hypogastric-plexus-in-an-interstitial-cystitis-patient-with-chronic-pain-and-symptoms-refractory-to-oral-and-intravesical-medications-and-bladder-hydrodistension-a-case-report
#9
Jong Hae Kim, Eugene Kim, Bong Il Kim
RATIONALE: A variety of therapeutic modalities are available for the treatment of interstitial cystitis. However, among them, the less invasive therapies are usually ineffective, whereas the invasive ones carry potential risks of serious side effects and complications. Pulsed radiofrequency (PRF) treatment of the superior hypogastric plexus may be an alternative to conventional treatments, as it provides nondestructive neuromodulation to the superior hypogastric plexus, which transmits the majority of pain signals from the pelvic viscera...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27855473/-tobacco-use-and-utilization-of-medical-services-in-adolescence-an-analysis-of-the-kiggs-data
#10
A M Fassmer, A Luque Ramos, C Boiselle, S Dreger, S Helmer, H Zeeb
Objective: In Germany, there is a lack of information on the correlation between tobacco use by adolescents and their utilization of medical care. The aim of this article is to identify possible early consequences of adolescent smoking. Methods: We conducted a re-analysis of cross-sectional data of the baseline wave (2003-2006) of the German Health Survey for Children and Adolescents (KiGGS). To examine the association between current smoking status and utilization of medical care during the 12 months before the interview, prevalence of selected diseases was calculated, and stratified by smoking status...
November 17, 2016: Das Gesundheitswesen
https://www.readbyqxmd.com/read/27805245/active-schistosomiasis-severe-hypereosinophilia-and-rapid-progression-of-chronic-endomyocardial-fibrosis
#11
A O Mocumbi, C Goncalves, A Damasceno, C Carrilho
Endomyocardial fibrosis (EMF) is a neglected restrictive cardiomyopathy of unknown aetiology and unclear natural history, which causes premature deaths in endemic areas. We present the case of a 13-year-old boy from a highly endemic area, presenting with concurrent signs of chronic EMF and severe hypereosinophilia associated with active schistosomal cystitis. We discuss the possible role of this parasitic infection in determining the progression of EMF in endemic areas for both conditions.
October 23, 2016: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/27795253/draft-genome-sequence-of-brazilian-escherichia-coli-uropathogenic-strain-e2
#12
Thiago G S Paim, Luiza Pieta, Janira Prichula, Gustavo E Sambrano, Renata Soares, Juliana Caierão, Jeverson Frazzon, Pedro A d'Azevedo
Escherichia coli is a common pathogen recovered from cystitis infections. In this report, we announce the draft genome sequence of strain E2 isolated from the urine specimen from a female patient in South Brazil. The genome assembly has 5,081,209 bp, a G+C content of 50.57%, and virulence factors associated with both enteroaggregative and uropathogenic E. coli strains.
October 6, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27788495/evaluating-the-efficacy-and-safety-of-intravesical-chemotherapies-for-non-muscle-invasive-bladder-cancer-a-network-meta-analysis
#13
Chuanjun Zhuo, Xubin Li, Hongqing Zhuang, Shunli Tian, Hailong Cui, Ronghuan Jiang, Chuanxin Liu, Ran Tao, Xiaodong Lin
Various intravesical therapies have been introduced into clinical practices for controlling non-muscle invasive bladder cancer (NMIBC). However, evidence with respect to the efficacy and safety of those intravesical therapies is very limited. Hence, we present a network meta-analysis in order to address this limitation in the current literature. The primary outcomes were the risk of tumor recurrence (TR), tumor progression (TP) and disease-specific mortality (DM). Secondary outcomes included the risk of fever, cystitis and haematuria...
October 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27732661/molecular-basis-of-acute-cystitis-reveals-susceptibility-genes-and-immunotherapeutic-targets
#14
Ines Ambite, Manoj Puthia, Karoly Nagy, Caterina Cafaro, Aftab Nadeem, Daniel S C Butler, Gustav Rydström, Nina A Filenko, Björn Wullt, Thomas Miethke, Catharina Svanborg
The clinical studies were approved by the Human Ethics Committee at Lund University (approval numbers LU106-02, LU236-99 and Clinical Trial Registration RTP-A2003, International Committee of Medical Journal Editors, www.clinicaltrials.gov).
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27694368/placement-of-subcutaneous-ureteral-bypasses-without-fluoroscopic-guidance-in-cats-with-ureteral-obstruction-19-cases-2014-2016
#15
Véronique Livet, Paul Pillard, Isabelle Goy-Thollot, David Maleca, Quentin Cabon, Denise Remy, Didier Fau, Éric Viguier, Céline Pouzot, Claude Carozzo, Thibaut Cachon
OBJECTIVES: The purpose of this study was to describe the perioperative and postoperative complications as well as short-term and long-term outcomes in cats with ureteral obstructions treated by placement of a subcutaneous ureteral bypass (SUB) device without imaging control. The second objective of this study was to compare cats treated by SUB device with cats treated by traditional surgical intervention. METHODS: Data were obtained retrospectively from the medical records (2014-2016) of cats that underwent SUB placement (SUB cats) and cats that underwent traditional ureteral surgery (C cats)...
September 30, 2016: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/27679168/treatment-of-bladder-pain-syndrome-and-interstitial-cystitis-a-systematic-review
#16
J C Rosa-E-Silva, C Pazin, Apm Silva, A M Mitidieri, M B Gurian
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27609597/in-vitro-susceptibility-to-mecillinam-of-escherichia-coli-strains-isolated-from-the-urine-of-pregnant-women
#17
C Duployez, C Loiez, C Cattoen, D Descamps, F Wallet, A Vachée
OBJECTIVES: Pivmecillinam is a safe beta-lactam for use in pregnancy. It has been widely used for the treatment of lower urinary tract infections (UTIs) in the Nordic countries where its efficacy, minor impact on the microbiota, and low level of resistance among the Escherichia coli strains have been proven. However, susceptibility data related to E. coli involved in asymptomatic bacteriuria and lower UTIs in pregnant women is lacking. We aimed to support the 2015 recommendations issued by the French Infectious Diseases Society (SPILF) on gestational UTI, with a particular focus on pivmecillinam...
December 2016: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/27595281/patterns-of-infection-and-infection-related-mortality-in-patients-with-steroid-refractory-acute-graft-versus-host-disease
#18
I García-Cadenas, I Rivera, R Martino, A Esquirol, P Barba, S Novelli, G Orti, J Briones, S Brunet, D Valcarcel, J Sierra
This study aimed to characterize the incidence, etiology and outcome of infectious episodes in patients with steroid refractory acute GvHD (SR-GvHD). The cohort included 127 adults treated with inolimomab (77%) or etanercept (23%) owing to acute 2-4 SR-GvHD, with a response rate of 43% on day +30 and a 4-year survival of 15%. The 1-year cumulative incidences of bacterial, CMV and invasive fungal infection were 74%, 65% and 14%, respectively. A high rate (37%) of enterococcal infections was observed. Twenty patients (15...
January 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/27581769/important-role-of-physicians-in-addressing-psychological-aspects-of-interstitial-cystitis-bladder-pain-syndrome-ic-bps-a-qualitative-analysis
#19
Gregory Kanter, Katherine A Volpe, Gena C Dunivan, Sara B Cichowski, Peter C Jeppson, Rebecca G Rogers, Yuko M Komesu
INTRODUCTION: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a poorly understood source of chronic pain causing significant morbidity, with variable treatment success. Despite the need to understand patient perspectives in chronic pain, there is a paucity of qualitative data for IC/BPS. We aimed to acquire information regarding patient experience with IC/BPS symptoms and with their medical care to elicit suggestions to improve patient satisfaction with that care. METHODS: Fifteen women with IC/PBS participated in a total of four focus groups...
August 31, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/27489498/protective-effect-of-thymoquinone-against-cyclophosphamide-induced-hemorrhagic-cystitis-through-inhibiting-dna-damage-and-upregulation-of-nrf2-expression
#20
Prashant R Gore, Chaitali P Prajapati, Umesh B Mahajan, Sameer N Goyal, Sateesh Belemkar, Shreesh Ojha, Chandragouda R Patil
Cyclophosphamide (CYP) induced hemorrhagic cystitis is a dose-limiting side effect involving increased oxidative stress, inflammatory cytokines and suppressed activity of nuclear factor related erythroid 2-related factor (Nrf2). Thymoquinone (TQ), an active constituent of Nigella sativa seeds, is reported to increase the expression of Nrf2, exert antioxidant action, and anti-inflammatory effects in the experimental animals. The present study was designed to explore the effects of TQ on CYP-induced hemorrhagic cystitis in Balb/c mice...
2016: International Journal of Biological Sciences
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