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https://www.readbyqxmd.com/read/29682797/mouse-urothelial-genes-associated-with-voiding-behavior-changes-after-ovariectomy-and-bladder-lipopolysaccharide-exposure
#1
Marian Acevedo-Alvarez, Judy Yeh, Lery Alvarez-Lugo, Ming Lu, Nitin Sukumar, Warren G Hill, Toby C Chai
AIMS: Symptoms from overactive bladder (OAB) and cystitis secondary to urinary tract infection (UTI) can be similar in post-menopausal women. Effects of ovariectomy (OVX) on voiding behavior after lipopolysaccharide (LPS) intravesical exposure (surrogate for cystitis) in mice were measured. Urothelial genes associated with micturition changes were identified. METHODS: Female C57BL6/J mice underwent OVX or sham surgeries (n = 10 for each). Voiding spot assays (VSA) were performed prior to surgery, 4 weeks post-surgery, and each time after 3 consecutive days of transurethral instillation of LPS...
April 23, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29679383/shortened-courses-of-antibiotics-for-bacterial-infections-a-systematic-review-of-randomized-controlled-trials
#2
Alexandra M Hanretty, Jason C Gallagher
BACKGROUND: Commonly prescribed durations of therapy for many, if not most, bacterial infections are not evidence-based. Misunderstandings by clinicians and patients alike influence perspectives on antibiotic use, including duration of therapy and its role in antibiotic resistance. OBJECTIVE: To demonstrate that shorter durations of antibiotic therapy are as efficacious as longer durations for many infections. DATA SOURCES: A systematic review of English language articles using PubMed were identified for inclusion...
April 20, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29613835/therapeutic-exploitation-of-ipse-a-urogenital-parasite-derived-host-modulatory-protein-for-chemotherapy-induced-hemorrhagic-cystitis
#3
Evaristus C Mbanefo, Loc Le, Luke F Pennington, Justin I Odegaard, Theodore S Jardetzky, Abdulaziz Alouffi, Franco H Falcone, Michael H Hsieh
Chemotherapy-induced hemorrhagic cystitis (CHC) can be difficult to manage. Prior work suggests that IL-4 alleviates ifosfamide-induced hemorrhagic cystitis (IHC), but systemically administered IL-4 causes significant side effects. We hypothesized that the Schistosoma hematobium homolog of IL-4-inducing principle from Schistosoma mansoni eggs (H-IPSE), would reduce IHC and associated bladder pathology. IPSE binds IgE on basophils and mast cells, triggering IL-4 secretion by these cells. IPSE is also an "infiltrin," translocating into the host nucleus to modulate gene transcription...
April 3, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29574093/alisma-canaliculatum-ethanol-extract-suppresses-inflammatory-responses-in-lps-stimulated-macrophages-hcl-etoh-induced-gastritis-and-dss-triggered-colitis-by-targeting-src-syk-and-tak1-activities
#4
Han Gyung Kim, Mi Yeon Kim, Jae Youl Cho
ETHNOPHARMACOLOGICAL RELEVANCE: Alisma canaliculatum A.Braun & C.D.Bouché, distributed in Korea, Japan, China, and Taiwan, is a traditional medicine. In particular, the stem and root of Alisma canaliculatum A.Braun & C.D.Bouché are prescribed to relieve various inflammatory symptoms resulting from nephritis, cystitis, urethritis, and dropsy. AIM OF STUDY: However, the curative mechanism of Alisma canaliculatum A.Braun & C.D.Bouché with respect to inflammatory symptoms is poorly understood...
March 21, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29571237/an-approach-to-treating-a-patient-with-a-heartmate-ii%C3%A2-left-ventricularassist-device-in-a-multiplace-hyperbaric-chamber-a-case-report
#5
D Orwig, C Logue, S Hendriksen, B Westgard, J Walter, M Pullis, T Masters
Introduction: Left-ventricular assist devices (LVAD) are becoming a common therapy for end-stage heart failure. These devicesare not tested for pressurization in a hyperbaricchamber by the manufacturer. In this article, we present an approach to modify the power supply in order to safely treat a patient with an LVAD. Materials and Methods: Our patient had a HeartMateII™ LVAD and presented for hyperbaric oxygen treatments for severe radiation cystitis. In order to modify this patient's equipment to be compliant with NFPA6 safety standards we made several modifications...
January 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29530925/changes-in-the-neuronal-control-of-the-urinary-bladder-in-a-model-of-radiation-cystitis
#6
Daniel Giglio, Lucie Podmolikova, Gunnar Tobin
Currently, we have assessed the neuronal control of the urinary bladder in radiation cystitis and whether interstitial cells contribute to the condition. Fourteen days following bladder irradiation (20 Gy) rats were sedated and the urinary bladder was cut in two sagittal halves where electrical field stimulation (EFS; 5-20 Hz) was applied on the pelvic nerve afferents or stretch (80 mN) on one half of the urinary bladder, while contractions were registered on the contralateral half of the urinary bladder in the absence and presence of increasing doses of imatinib (1-10 mg/kg; inhibitor of c-kit+ interstitial cells), atropine (1 mg/kg; to block muscarinic M3 receptors) or PPADS (2 mg/kg; to block P2X1 purinoceptors)...
March 12, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29526581/-the-dimethyl-sulfoxide-under-general-anesthesia-an-alternative-after-failure-without-anesthesia-in-the-painful-bladder-syndrome-interstitial-cystitis
#7
M Gaullier, T Tricard, P Mouracade, C Saussine
INTRODUCTION: The intravesical instillation of dimethyl sulfoxide (iDMSO), performed without anesthestic, is a therapeutic option for the painful bladder syndrome/interstial cystitis (PBS/IC). Some patients are against those iDMSO because of bad tolerance. Our study evaluates the tolerance and the outcome of the iDMSO under general anesthetic (GA) after the failure of the iDMSO without anesthetic. PATIENTS AND METHODS: From May 2013 to April 2016, 11 patients with a PBS, 9 women (81...
March 8, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29518863/-clinical-study-of-low-cytomegalovirus-viral-load-thresholds-for-preemptive-antiviral-therapy-in-hematopoietic-cell-transplant-recipients
#8
L Li, Y Wang, C H Yan, X J Huang
Objective: To investigate the threshold of cytomegalovirus (CMV) DNAemia for preemptive antiviral therapy in patients with allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods: Viral load between 1×10(3) copies/ml and 5×10(3) copies/ml was defined as low viral load by real time Q-PCR. Clinical data and outcome were collected. Results: A total of 95 allo-HSCT recipients with low viral load from September 2014 to February 2015 were recruited in this study. The control group included 37 patients who received preemptive initial antiviral therapy...
March 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29501360/depression-and-coping-behaviors-are-key-factors-in-understanding-pain-in-interstitial-cystitis-bladder-pain-syndrome
#9
Abi Muere, Dean A Tripp, J Curtis Nickel, Kerri-Lynn Kelly, Robert Mayer, Michel Pontari, Robert Moldwin, Lesley K Carr, Claire C Yang, Jorgen Nordling
Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a urologic chronic pelvic pain syndrome with suboptimal treatment outcomes. Catastrophizing is an empirically supported risk factor for greater IC/BPS pain. In this study, a moderated multiple mediation model is tested in which several additional psychosocial risk factors (depression, illness and wellness-focused behavioral coping strategies) are proposed as mediators or moderators in the existing relationship between catastrophizing and IC/BPS pain. The present questionnaire study employed a cross-sectional design...
February 28, 2018: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/29464752/voluntary-wheel-running-attenuates-urinary-bladder-hypersensitivity-and-dysfunction-following-neonatal-maternal-separation-in-female-mice
#10
Angela N Pierce, Olivia C Eller-Smith, Julie A Christianson
AIMS: Patients with interstitial cystitis/painful bladder syndrome (IC/PBS) commonly suffer from widespread pain and mood disorder, which has been attributed to improper functioning of the hypothalamic-pituitary-adrenal (HPA) axis. Voluntary exercise has been shown to improve HPA axis function, therefore we are determining whether voluntary wheel running can attenuate urological pain and dysfunction following neonatal maternal separation (NMS) in female mice. METHODS: Mice underwent NMS for 3 h/day from postnatal Day 1-21, were caged with free access to running wheels at 4 weeks of age, and assessed 4 weeks later for bladder sensitivity, micturition, reward behavior, mast cell degranulation, and HPA axis-related in vitro analysis...
February 21, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29460790/protein-and-micronutrient-deficiencies-in-patients-with-radiation-cystitis-and-outcome-after-hyperbaric-oxygen-therapy
#11
Valérie Platzer, Guillaume Perez, Anne Galinier, Michèle Genestal, Béatrice Riu-Poulenc, Leslie Gonzalez, Eric Huyghe, Sylvie Caspar-Bauguil
BACKGROUND & AIMS: Haemorrhagic radiation cystitis (HRC) is a late complication of pelvic radiotherapy. Severe cases are difficult to treat due to persistent or recurrent bleeding, despite urological and hyperbaric oxygen therapy (HBOT). However, wound healing requires a good nutritional status. In this respect, we aimed at analysing the nutritional status of patients with HRC prior to the onset of HBOT and at highlighting predictive nutritional factors of outcome. METHODS: Data were retrospectively collected from a cohort of 179 patients with HRC (between 2011 and 2015)...
February 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29417760/fosfomycin-as-a-potential-therapy-for-the-treatment-of-systemic-infections-a-population-pharmacokinetic-model-to-simulate-multiple-dosing-regimens
#12
Natalia V Ortiz Zacarías, Anneke C Dijkmans, Jacobus Burggraaf, Johan W Mouton, Erik B Wilms, Cees van Nieuwkoop, Daan J Touw, Ingrid M C Kamerling, Jasper Stevens
Fosfomycin has emerged as a potential therapy for multidrug-resistant bacterial infections. In most European countries, the oral formulation is only approved as a 3 g single dose for treatment of uncomplicated cystitis. However, for the treatment of complicated systemic infections, this dose regimen is unlikely to reach efficacious serum and tissue concentrations. This study aims to investigate different fosfomycin-dosing regimens to evaluate its rationale for treatment of systemic infections. Serum concentration-time profiles of fosfomycin were simulated using a population pharmacokinetic model based on published pharmacokinetic parameter values, their uncertainty, inter-individual variability and covariates...
February 2018: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/29402306/sustainable-reduction-of-antibiotic-induced-antimicrobial-resistance-arena-in-german-ambulatory-care-study-protocol-of-a-cluster-randomised-trial
#13
Martina Kamradt, Petra Kaufmann-Kolle, Edith Andres, Tonia Brand, Anja Klingenberg, Katharina Glassen, Regina Poß-Doering, Lorenz Uhlmann, Katharina Hees, Dorothea Weber, Andreas Gutscher, Veit Wambach, Joachim Szecsenyi, Michel Wensing
BACKGROUND: Despite many initiatives to enhance the rational use of antibiotics, there remains substantial room for improvement. The overall aim of this study is to optimise the appropriate use of antibiotics in German ambulatory care in patients with acute non-complicated infections (respiratory tract infections, such as bronchitis, sinusitis, tonsillitis and otitis media), community-acquired pneumonia and non-complicated cystitis, in order to counter the advancing antimicrobial resistance development...
February 5, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29394134/chronic-cystitis-associated-with-plesiochorus-cymbiformis-rudolphi-1819-looss-1901-digenea-gorgoderidae-in-a-loggerhead-turtle-caretta-caretta-linnaeus-1758-testudines-cheloniidae-from-brazil
#14
Max Rondon Werneck, Adriana Mastrangelli, Renato Velloso, Hassan Jerdy, Eulógio C Q Carvalho
This paper reports the first discovery of Plesiochorus cymbiformis (Digenea: Gorgoderidae) from a loggerhead turtle [Caretta caretta (Testudines, Cheloniidae)] in Brazil and describes the histological findings of related injuries to the urinary bladder.
February 2, 2018: Journal of Parasitology
https://www.readbyqxmd.com/read/29358784/-uncomplicated-urinary-tract-infections-antimicrobial-susceptibility-study-in-navarre
#15
A Aguinaga, A Gil-Setas, A Mazón Ramos, A Alvaro, J J García-Irure, A Navascués, C Ezpeleta Baquedano
BACKGROUND: Urinary tract infection (UTI) is a high prevalence infection at the community level. In order to improve the adequacy of the empirical therapy, we evaluated the etiology and the resistance pattern of the main uropathogens responsible for community acquired UTI in Navarre. METHODS: Retrospective study (2014-2016) in which we included microorganisms recovered with significant counts from samples of patients with community-acquired UTI. The global etiology and etiology according to age and sex was analyzed...
January 23, 2018: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/29288643/a-case-crossover-study-of-urological-chronic-pelvic-pain-syndrome-flare-triggers-in-the-mapp-research-network
#16
Siobhan Sutcliffe, Thomas Jemielita, H Henry Lai, Gerald L Andriole, Catherine S Bradley, J Quentin Clemens, Robert Gallop, Thomas M Hooton, Karl J Kreder, John N Krieger, John W Kusek, Jennifer Labus, M Scott Lucia, Sean Mackey, Bruce D Naliboff, Nancy A Robinson, Larissa V Rodriguez, Alisa Stephens-Shields, Adrie van Bokhoven, Kathleen Y Wolin, Yan Yan, Claire C Yang, J Richard Landis, Graham A Colditz
PURPOSE: Although many factors have been proposed to trigger symptom exacerbations (flares) in patients with interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome, few studies have investigated these factors empirically. Therefore, we embedded a case-crossover study in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain longitudinal study to evaluate a range of patient reported triggers. MATERIALS AND METHODS: We assessed exposure to proposed triggers, including diet, physical activities, sedentary behaviors, stress, sexual activities, infection-like symptoms and allergies, by questionnaire a maximum of 3 times when participants reported flares and at 3 randomly selected times...
December 27, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29277656/unmasking-of-urinary-pubic-symphysis-fistula-after-implantation-of-artificial-urinary-sphincter-in-prostate-cancer-survivors-user-beware
#17
Arman A Kahokehr, Andrew C Peterson
OBJECTIVE: To describe the dramatic and rapid unmasking of urinary-pubic symphysis fistula (UPF) and chronic osteomyelitis after artificial urinary sphincter (AUS) implantation. This has never been reported as UPF is usually an insidious sequelae of radiotherapy or energy ablation for prostate cancer. METHODS: We prospectively identified men who underwent rapid clinical decline due to UPF soon after AUS implantation at our institution in the previous 24 months. Chart and imaging was reviewed to assess preoperative and postoperative factors...
December 23, 2017: Urology
https://www.readbyqxmd.com/read/29249972/pathophysiological-role-of-transient-receptor-potential-ankyrin-1-in-a-mouse-long-lasting-cystitis-model-induced-by-an-intravesical-injection-of-hydrogen-peroxide
#18
Shohei Oyama, Koji Dogishi, Mizuki Kodera, Masashi Kakae, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko
Chronic inflammatory bladder disorders, such as interstitial cystitis/bladder pain syndrome, are associated with poor quality of life. The exact pathological processes remain unclear, but accumulating evidence suggests that reactive oxidative species (ROS) are involved in urinary bladder disorders. Transient receptor potential ankyrin 1 (TRPA1), the most sensitive TRP channel to ROS, was shown to be responsible for urinary bladder abnormalities and hyperalgesia in an acute cystitis model. However, the roles of TRPA1 in chronic inflammatory bladder are not fully understood...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29226304/successful-medical-management-of-pseudomembranous-cystitis-in-three-cats-with-lower-urinary-tract-obstruction
#19
A Vila, R Movilla, J Castro, C Mallol, R Novellas, Y Espada, X Roura
CASE REPORT: The present case series describes the clinical course and outcome of three cats diagnosed with pseudomembranous cystitis. This is an uncommon presentation of lower urinary tract obstruction but can be easily be identified by ultrasonography, revealing severe bladder wall thickening and thin hyperechoic luminal strips. The condition can be secondary to severe bacterial urinary tract infection. All cats were successfully treated with medical management only, mainly based on antimicrobials and individualised supportive therapy...
January 2018: Australian Veterinary Journal
https://www.readbyqxmd.com/read/29198679/treatment-of-a-pediatric-case-of-severe-hemorrhagic-cystitis-case-report-and-review-of-literature
#20
L Yang, Y Zha, J Feng, H Dong, C Zong, X Lei, N Liang, X Wang, G Gao, X Bai
Hemorrhagic cystitis is one of the complications of allogeneic hematopoietic stem cell transplantation. Treatment of hemorrhagic cystitis is difficult, especially in pediatric patients. A pediatric case of severe hemorrhagic cystitis after hematopoietic stem cell transplantation was treated in our hospital with arterial embolization combined with corticosteroid therapy because the conventional therapy was invalid for him. After the treatment, hemorrhagic cystitis was cured. During follow-up, the patient was in stable condition, with normal urine, blood cells returned to normal, bone marrow was in complete remission state, and disease-free survival for more than 8 months...
December 2017: Transplantation Proceedings
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