keyword
https://read.qxmd.com/read/38406032/rhizarthrosis-part-i-a-literature-review
#21
REVIEW
Saverio Colonna, Corrado Borghi
Rhizarthrosis (RA), or trapeziometacarpal osteoarthritis, is an arthritic degenerative process that affects the first joint of the thumb. The objective of this work is to provide therapists with an overview of the fundamental issues related to the therapeutic management of trapeziometacarpal joint instability. Prevalent in females, especially post-menopause, and linked to age, RA involves ligament and muscle structures, with causes ranging from hormonal influences to mechanical factors. Understanding the biomechanics, stability, and factors contributing to RA is crucial for effective intervention...
January 2024: Curēus
https://read.qxmd.com/read/38406019/dysphagia-in-a-patient-with-lewy-body-dementia-and-incidental-anterior-cervical-osteophyte-a-case-report
#22
Gurjot Singh, Didar Singh, Gurleen Kaur, Piyush Puri, Tanya Ratnani, Ridhi Bhagat
One of the common problems affecting the elderly is dysphagia, which can be brought on by several things, including the presence of anterior cervical osteophytes. In this case study, a patient with Lewy body dementia is shown to have a case of dysphagia. The patient's primary complaint was dysphagia, which prompted questions regarding the development of underlying Lewy body dementia combined with gradual cognitive deterioration and motor control problems. An upper GI endoscopy was conducted during the patient's hospitalization after a barium swallow suggested esophageal obstruction but found no internal obstruction or any other abnormalities...
January 2024: Curēus
https://read.qxmd.com/read/38401343/unicompartmental-knee-arthroplasty-questionnaire-uniq-study-unknown-is-unloved
#23
JOURNAL ARTICLE
Stephan J van Langeveld, Iris Koenraadt-van Oost, Sander Spruijt, Stefan J M Breugem, Gino M M J Kerkhoffs, Rutger C I van Geenen
BACKGROUND: Almost 50% of the patients requiring knee replacement are suitable for medial unicompartmental knee arthroplasty (UKA). However, national registries have shown a use far below 50%. AIM: The aim of this study was to identify the factors that could influence the use of UKA. METHODS: A questionnaire was conducted among practicing knee surgeons of the Dutch Orthopedic Association. The questionnaire was classified into three domains: surgeon, patient selection, and professional opinion...
February 23, 2024: Knee
https://read.qxmd.com/read/38396204/transcript-dependent-effects-of-the-calca-gene-on-the-progression-of-post-traumatic-osteoarthritis-in-mice
#24
JOURNAL ARTICLE
Shan Jiang, Weixin Xie, Paul Richard Knapstein, Antonia Donat, Lilly-Charlotte Albertsen, Jan Sevecke, Cordula Erdmann, Jessika Appelt, Melanie Fuchs, Alexander Hildebrandt, Tazio Maleitzke, Karl-Heinz Frosch, Anke Baranowsky, Johannes Keller
Osteoarthritis represents a chronic degenerative joint disease with exceptional clinical relevance. Polymorphisms of the CALCA gene, giving rise to either a procalcitonin/calcitonin (PCT/CT) or a calcitonin gene-related peptide alpha (αCGRP) transcript by alternative splicing, were reported to be associated with the development of osteoarthritis. The objective of this study was to investigate the role of both PCT/CT and αCGRP transcripts in a mouse model of post-traumatic osteoarthritis (ptOA). WT, αCGRP-/- and CALCA-/- mice were subjected to anterior cruciate ligament transection (ACLT) to induce ptOA of the knee...
February 23, 2024: Communications Biology
https://read.qxmd.com/read/38395992/piezo1-expression-in-chondrocytes-controls-endochondral-ossification-and-osteoarthritis-development
#25
JOURNAL ARTICLE
Laura J Brylka, Assil-Ramin Alimy, Miriam E A Tschaffon-Müller, Shan Jiang, Tobias Malte Ballhause, Anke Baranowsky, Simon von Kroge, Julian Delsmann, Eva Pawlus, Kian Eghbalian, Klaus Püschel, Astrid Schoppa, Melanie Haffner-Luntzer, David J Beech, Frank Timo Beil, Michael Amling, Johannes Keller, Anita Ignatius, Timur A Yorgan, Tim Rolvien, Thorsten Schinke
Piezo proteins are mechanically activated ion channels, which are required for mechanosensing functions in a variety of cell types. While we and others have previously demonstrated that the expression of Piezo1 in osteoblast lineage cells is essential for bone-anabolic processes, there was only suggestive evidence indicating a role of Piezo1 and/or Piezo2 in cartilage. Here we addressed the question if and how chondrocyte expression of the mechanosensitive proteins Piezo1 or Piezo2 controls physiological endochondral ossification and pathological osteoarthritis (OA) development...
February 23, 2024: Bone Research
https://read.qxmd.com/read/38386579/pathological-priors-inspired-network-for-vertebral-osteophytes-recognition
#26
JOURNAL ARTICLE
Junzhang Huang, Xiongfeng Zhu, Ziyang Chen, Guoye Lin, Meiyan Huang, Qianjin Feng
Automatic vertebral osteophyte recognition in Digital Radiography is of great importance for the early prediction of degenerative disease but is still a challenge because of the tiny size and high inter-class similarity between normal and osteophyte vertebrae. Meanwhile, common sampling strategies applied in Convolution Neural Network could cause detailed context loss. All of these could lead to an incorrect positioning predicament. In this paper, based on important pathological priors, we define a set of potential lesions of each vertebra and propose a novel Pathological Priors Inspired Network (PPIN) to achieve accurate osteophyte recognition...
February 22, 2024: IEEE Transactions on Medical Imaging
https://read.qxmd.com/read/38386060/bone-deformity-in-sports-related-elbow-osteoarthritis-influence-of-osteochondritis-dissecans-of-the-capitellum-a-cross-sectional-study
#27
JOURNAL ARTICLE
Ko Temporin, Yuji Miyoshi, Satoshi Miyamura, Kozo Shimada
INTRODUCTION: Sports activity can cause elbow osteoarthritis, which subsequently induces bone deformity. Osteochondritis dissecans (OCD) of the capitellum develops defects of articular surfaces and can exacerbate bone deformity. This study aimed to investigate whether OCD exacerbates deformities in sports-related elbow osteoarthritis. MATERIALS AND METHODS: Twenty-one patients who underwent bilateral computed tomography preoperatively followed by surgery for sports-related elbow osteoarthritis were included...
February 22, 2024: Archives of Orthopaedic and Trauma Surgery
https://read.qxmd.com/read/38362483/three-dimensional-reconstruction-of-computed-tomography-imaging-is-not-reliable-in-assessing-acetabular-rim-osteophytes-or-acetabular-rim-pathology-in-patients-with-femoroacetabular-impingement
#28
JOURNAL ARTICLE
Hanmei Dong, Maihemuti Maimaitimin, Chenbo Jiao, Yuhao Liu, Guanying Gao, Tongchuan He, Yan Xu
PURPOSE: To determine the reliability of 3-dimensional (3D) reconstruction of computed tomography (CT) imaging in evaluating acetabular rim morphology or acetabular rim osteophyte (ARO) existence and to group patients with femoroacetabular impingement (FAI) by ARO extent on coronal sections of CT and further compare clinical differences among groups. METHODS: Patients who underwent primary hip arthroscopy for FAI by the same surgeon between August 2016 and December 2018 with minimum 2-year follow-up were enrolled...
April 2024: Arthroscopy, sports medicine, and rehabilitation
https://read.qxmd.com/read/38358041/near-infrared-responsive-gold-nanorods-attenuate-osteoarthritis-progression-by-targeting-trpv1
#29
JOURNAL ARTICLE
Weitong Li, Zhongyang Lv, Peng Wang, Ya Xie, Wei Sun, Hu Guo, Xiaoyu Jin, Yuan Liu, Ruiyang Jiang, Yuxiang Fei, Guihua Tan, Huiming Jiang, Xucai Wang, Zizheng Liu, Zheng Wang, Nuo Xu, Wenli Gong, Rui Wu, Dongquan Shi
Osteoarthritis (OA) is the most common degenerative joint disease worldwide, with the main pathological manifestation of articular cartilage degeneration. It have been investigated that pharmacological activation of transient receptor potential vanilloid 1 (TRPV1) significantly alleviated cartilage degeneration by abolishing chondrocyte ferroptosis. In this work, in view of the thermal activated feature of TRPV1, Citrate-stabilized gold nanorods (Cit-AuNRs) is conjugated to TRPV1 monoclonal antibody (Cit-AuNRs@Anti-TRPV1) as a photothermal switch for TRPV1 activation in chondrocytes under near infrared (NIR) irradiation...
February 15, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38345195/%C3%AE-solanine-attenuates-chondrocyte-pyroptosis-to-improve-osteoarthritis-via-suppressing-nf-%C3%AE%C2%BAb-pathway
#30
JOURNAL ARTICLE
Jinyi Zhou, Jinting Wu, Fangda Fu, Sai Yao, Wenbiao Zheng, Weibin Du, Huan Luo, Hongting Jin, Peijian Tong, Chengliang Wu, Hongfeng Ruan
α-Solanine has been shown to exhibit anti-inflammatory and anti-tumour properties; however, its efficacy in treating osteoarthritis (OA) remains ambiguous. The study aimed to evaluate the therapeutic effects of α-solanine on OA development in a mouse OA model. The OA mice were subjected to varying concentrations of α-solanine, and various assessments were implemented to assess OA progression. We found that α-solanine significantly reduced osteophyte formation, subchondral sclerosis and OARSI score...
February 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38344621/physiotherapeutic-approach-for-paraparesis-resulting-from-l2-s1-disc-bulge-along-with-diabetic-neuropathy-a-case-report
#31
Reva Rajurkar, Pallavi Harjpal, Priya Tikhile
A degenerative disc disease is characterized by osteophytes, disc space reduction, nerve compression and discomfort are all symptoms of disc bulging. Diabetic neuropathy, a condition leading to significant health issues, involves a sensory dysfunction initiating in the lower extremities and progressing to pain. In the present case, a 61-year-old retired physical training teacher came to the hospital with complaints of difficulty in walking, sitting, and standing in the past two years. The patient also complained of a tingling sensation in the upper and lower limbs, low back pain, and body stiffness...
January 2024: Curēus
https://read.qxmd.com/read/38343826/development-of-primary-osteoarthritis-during-aging-in-genetically-diverse-um-het3-mice
#32
Sher Bahadur Poudel, Ryan R Ruff, Gozde Yildirim, Richard A Miller, David E Harrison, Randy Strong, Thorsten Kirsch, Shoshana Yakar
Background Primary osteoarthritis (OA) occurs without identifiable underlying causes such as previous injuries or specific medical conditions. Age is a major contributing factor to OA, and as one ages, various joint tissues undergo gradual change, including degeneration of the articular cartilage, alterations in subchondral bone (SCB) morphology, and inflammation of the synovium. Methods We investigated the prevalence of primary OA in aged, genetically diverse UM-HET3 mice. Articular cartilage (AC) integrity and SCB morphology were assessed in 182 knee joints of 22-25 months old mice using the Osteoarthritis Research Society International (OARSI) scoring system and micro-CT, respectively...
January 22, 2024: Research Square
https://read.qxmd.com/read/38343165/how-does-resorption-differ-amongst-single-and-multi-level-lumbar-disc-herniations-a-prospective-multi-imaging-and-clinical-phenotype-study
#33
JOURNAL ARTICLE
Alexander L Hornung, Samuel S Rudisill, J Nicolas Barajas, Garrett Harada, Ashlyn A Fitch, Skylar F Leonard, Ashley C Roberts, Howard S An, Hanne B Albert, Alexander Tkachev, Dino Samartzis
STUDY DESIGN: Prospective, Case Series. OBJECTIVE: To identify and characterize any differences in specific patient factors, MRI findings, features of spontaneous disc resorption, and outcomes between patients with single- and multi-level LDH. BACKGROUND: Lumbar disc herniation (LDH) is one of the most common spinal pathologies worldwide. Though many cases of LDH resolve by spontaneous resorption, the mechanism underlying this "self-healing" phenomenon remains poorly understood, particularly in the context of multi-level herniations...
February 12, 2024: Spine
https://read.qxmd.com/read/38327918/an-anatomorphometric-study-of-occipital-spurs-and-their-association-with-dental-occlusion
#34
JOURNAL ARTICLE
Fatma Çağlayan, Berfin Polat, Hatice L Tugluoglu Dalci, Esra Oncu, Nida Kuzey, Hatice Guller
Background and objective The occipital spur (OS) can be described as an abnormal elongation of the external occipital protuberance (EOP); its etiology is multifactorial and may involve biomechanical, immunological, and/or genetic factors. This study aimed to determine the frequency and characteristics of elongated EOP or OS as well as the relationship of OS with occlusion in a group of Turkish dental patients. Materials and methods Lateral cephalometric radiographs of 1925 patients taken in 2022 were retrospectively analyzed...
January 2024: Curēus
https://read.qxmd.com/read/38323840/deep-learning-based-detection-of-osteophytes-in-radiographs-and-magnetic-resonance-imagings-of-the-knee-using-2d-and-3d-morphology
#35
JOURNAL ARTICLE
Mitra Daneshmand, Egor Panfilov, Neslihan Bayramoglu, Rami K Korhonen, Simo Saarakkala
In this study, we investigated the discriminative capacity of knee morphology in automatic detection of osteophytes defined by the Osteoarthritis Research Society International atlas, using X-ray and magnetic resonance imaging (MRI) data. For the X-ray analysis, we developed a deep learning (DL) based model to segment femur and tibia. In case of MRIs, we utilized previously validated segmentations of femur, tibia, corresponding cartilage tissues, and menisci. Osteophyte detection was performed using DL models in four compartments: medial femur (FM), lateral femur (FL), medial tibia (TM), and lateral tibia (TL)...
February 7, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38312293/influence-of-acromioclavicular-joint-arthritis-on-outcomes-after-reverse-total-shoulder
#36
JOURNAL ARTICLE
Bryce S Schneider, Kevin A Hao, Jeremy K Taylor, Jonathan O Wright, Thomas W Wright, Marissa Pazik, Bradley S Schoch, Joseph J King
BACKGROUND: Although substantial motion at the acromioclavicular joint (ACJ) occurs during overhead shoulder motion, the influence of ACJ arthritis on postoperative outcomes of patients undergoing reverse total shoulder arthroplasty (rTSA) is unclear. We assessed the influence of ACJ arthritis, defined by degenerative radiographic changes, and its severity on clinical outcomes after primary rTSA. METHODS: We conducted a retrospective review of a prospectively collected shoulder arthroplasty database of patients that underwent primary rTSA with a minimum 2-year clinical follow-up...
January 2024: JSES international
https://read.qxmd.com/read/38312277/effect-of-osteophyte-removal-on-simulated-range-of-motion-using-3-dimensional-preoperative-planning-software-for-reverse-total-shoulder-arthroplasty
#37
JOURNAL ARTICLE
Joseph J Ruzbarsky, Annalise M Peebles, Lauren Watkins, Amelia R Kruse, Brendan M Lilley, Stephanie K Eble, Patrick J Denard, Anthony A Romeo, Matthew T Provencher
BACKGROUND: Glenohumeral osteophytes (OPs) can adversely influence postoperative range of motion (ROM) following shoulder arthroplasty due to mechanical impingement. Though commercial three-dimensional preoperative planning software (3D PPS) is available to simulate ROM before and after OP resection, little is known about the magnitude of effect OPs and their subsequent removal have on simulated glenohumeral ROM. METHODS: Included patients were 1) indicated for reverse total shoulder arthroplasty (rTSA) using 3D PPS and 2) presented with glenoid and/or humeral head OPs on preoperative two-dimensional computed tomography (2D-CT) imaging...
January 2024: JSES international
https://read.qxmd.com/read/38312262/a-cross-sectional-observational-study-comparing-individuals-with-a-symptomatic-full-thickness-rotator-cuff-tear-with-age-matched-controls
#38
JOURNAL ARTICLE
Marianne Roos, Michaël Bertrand-Charette, Marc-Olivier Dubé, Jean Tittley, Mélanie Brisson, Luc Chau, Jackie L Whittaker, François Desmeules, Catherine Mercier, Jean-Sébastien Roy
BACKGROUND: A full-thickness rotator cuff tear (FTRCT) is defined as a complete tear of one of the four rotator cuff muscle tendons (supraspinatus, infraspinatus, subscapularis or teres minor). This condition can lead to pain and reduced function. However, not all FTRCT are symptomatic. A better understanding of the characteristics that lead some individuals with FTRCT to experience pain is fundamental to improve strategies used to manage this condition. This level II descriptive study aimed to explore potential sociodemographic, anatomical, psychosocial, pain sensitivity, biomechanical and neuromuscular variables that may differ between individuals with symptomatic FTRCT and age-matched individuals with asymptomatic shoulders...
January 2024: JSES international
https://read.qxmd.com/read/38310093/5-aminosalicylic-acid-suppresses-osteoarthritis-through-the-oscar-ppar%C3%AE-axis
#39
JOURNAL ARTICLE
Jihee Kim, Gina Ryu, Jeongmin Seo, Miyeon Go, Gyungmin Kim, Sol Yi, Suwon Kim, Hana Lee, June-Yong Lee, Han Sung Kim, Min-Chan Park, Dong Hae Shin, Hyunbo Shim, Wankyu Kim, Soo Young Lee
Osteoarthritis (OA) is a progressive and irreversible degenerative joint disease that is characterized by cartilage destruction, osteophyte formation, subchondral bone remodeling, and synovitis. Despite affecting millions of patients, effective and safe disease-modifying osteoarthritis drugs are lacking. Here we reveal an unexpected role for the small molecule 5-aminosalicylic acid (5-ASA), which is used as an anti-inflammatory drug in ulcerative colitis. We show that 5-ASA competes with extracellular-matrix collagen-II to bind to osteoclast-associated receptor (OSCAR) on chondrocytes...
February 3, 2024: Nature Communications
https://read.qxmd.com/read/38309612/casticin-ameliorates-osteoarthritic-cartilage-damage-in-rats-through-pi3k-akt-hif-1%C3%AE-signaling
#40
JOURNAL ARTICLE
Deren Liu, Wei Mei, Junfeng Kang, Taiyang Liao, Yibao Wei, Lishi Jie, Lei Shi, Peimin Wang, Jun Mao, Peng Wu
Knee osteoarthritis (KOA) is a chronic, disabling knee joint lesion in which degeneration and defects in articular cartilage are the most important features. Casticin (CAS) is a flavonoid extracted from the Chinese herb Vitex species that has anti-inflammatory and antitumor effects. The aim of this study was to investigate the therapeutic and mechanistic effects of CAS on cartilage damage in KOA. A KOA rat model was established by anterior cruciate ligament transection (ACLT), and cartilage morphological changes were assessed by histological analysis and micro-CT scans...
February 1, 2024: Chemico-biological Interactions
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