Weitong Li, Zhongyang Lv, Peng Wang, Ya Xie, Wei Sun, Hu Guo, Xiaoyu Jin, Yuan Liu, Ruiyang Jiang, Yuxiang Fei, Guihua Tan, Huiming Jiang, Xucai Wang, Zizheng Liu, Zheng Wang, Nuo Xu, Wenli Gong, Rui Wu, Dongquan Shi
Osteoarthritis (OA) is the most common degenerative joint disease worldwide, with the main pathological manifestation of articular cartilage degeneration. It have been investigated that pharmacological activation of transient receptor potential vanilloid 1 (TRPV1) significantly alleviated cartilage degeneration by abolishing chondrocyte ferroptosis. In this work, in view of the thermal activated feature of TRPV1, Citrate-stabilized gold nanorods (Cit-AuNRs) is conjugated to TRPV1 monoclonal antibody (Cit-AuNRs@Anti-TRPV1) as a photothermal switch for TRPV1 activation in chondrocytes under near infrared (NIR) irradiation...
February 15, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)