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https://www.readbyqxmd.com/read/27909665/autologous-osteophyte-grafting-for-open-wedge-high-tibial-osteotomy
#1
Takenori Akiyama, Ken Okazaki, Taro Mawatari, Satoshi Ikemura, Shunsuke Nakamura
Osteophytes are physiological bony outgrowths that develop at the margins of the articular surfaces during the progression of osteoarthritis; they are associated with active endochondral bone formation processes and expressions of various growth factors. We believe they could be a source of bone grafts as a result of a potentially strong osteoinductive effect. Moreover, osteophytes can be easily harvested by arthroscopy in patients undergoing open-wedge high tibial osteotomy (OW-HTO) for medial unicompartmental knee osteoarthritis...
October 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/27906853/surgical-management-of-dysphagia-due-to-anterior-cervical-osteophytes
#2
Ömer Erdur, Hamdi Taşli, Bahtiyar Polat, Fuad Sofiyev, Fuat Tosun, Bahar Çolpan, Hakan Birkent, Kayhan Öztürk
PURPOSE: The present study was performed to share personal experiences and to discuss the advantages and disadvantages of anterior cervical osteophytes surgical procedures. METHODS: The operative records of anterior cervical osteophytes patients who did not benefit from conventional treatments and underwent osteophytectomy were analyzed retrospectively. Transoral and transcervical anterolateral methods were applied, considering both the localization of the osteophyte and the patient's preference...
November 30, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27900195/knee-osteoarthritis-in-traumatic-knee-symptoms-in-general-practice-6-year-cohort-study
#3
Marlous Kastelein, Pim A J Luijsterburg, Ingrid M Koster, Jan A N Verhaar, Bart W Koes, Dammis Vroegindeweij, Sita M A Bierma-Zeinstra, Edwin H G Oei
AIM: To identify degenerative knee abnormalities using MRI and radiography 6 years after knee trauma, their relation with persistent knee symptoms and baseline prognostic factors. METHODS: Adults (18-65 years) with incident traumatic knee symptoms visiting their general practitioner were followed up for 6 years and underwent baseline MRI and 6-year follow-up MRI and radiography. Logistic regression was used to analyse associations between various degenerative abnormalities on 6-year MRI and radiography, persistent knee symptoms and baseline prognostic factors for knee osteoarthritis (OA) on 6-year MRI...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27896816/altered-pharyngeal-structure-and-dynamics-among-patients-with-cervical-kyphosis
#4
Derrick R Randall, E Brandon Strong, Peter C Belafsky
OBJECTIVES/HYPOTHESIS: Deformities of the anterior cervical spine are an established cause of dysphagia. Whereas osteophytes and spinal fusion hardware have been reported to alter bolus flow and contribute to swallowing dysfunction, the relationship between abnormal spine curvature and swallowing dysfunction is not established. The purpose of this investigation was to evaluate the association between cervical kyphosis and objective measures of swallowing dysfunction on videofluoroscopy...
November 29, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27891363/giant-cervical-osteophyte-an-unusual-cause-of-dysphagia
#5
Sudhir Kumar Srivastava, Sunil Krishna Bhosale, Tanvi Anoop Lohiya, Rishi Anil Aggarwal
Dysphagia due to skeletal causes is a rare entity. A large cervical osteophyte can cause mechanical compression of the pharyngo-oesophageal segment leading to dysphagia. Large cervical osteophytes can occur in cervical spondylosis, ankylosing spondylitis or Diffuse Idiopathic Skeletal Hyperostosis (DISH). A 60-year-old female came with progressive dysphagia due to a giant cervical osteophyte anterior to C4 and C5 vertebral bodies causing compression of the pharyngo-oesophageal segment. The patient was treated by surgical excision of the osteophyte by orthopaedic surgeons...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27890763/positional-occlusion-of-vertebral-artery-due-to-cervical-spondylosis-as-rare-cause-of-wake-up-stroke-report-of-2-cases
#6
Hirofumi Nishikawa, Fumitaka Miya, Yotaro Kitano, Genshin Mori, Shigetoshi Shimizu, Hidenori Suzuki
BACKGROUND: Positional compression of the vertebral artery (VA) due to cervical spondylosis is an uncommon cause of stroke. We report two cases of cervical spondylosis causing wake-up stroke, which is extremely rare. CASE DESCRIPTION: The first case was a 78-year-old woman who presented with vertigo and vomiting lasting from waking up. Magnetic resonance (MR) images and angiography documented right cerebellar infarction, and stenosis of the right cervical VA. Dynamic angiography revealed that the right VA was occluded when her neck was extended or rotated to the right...
November 24, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27884778/expression-of-adipokines-in-osteoarthritis-osteophytes-and-their-effect-on-osteoblasts
#7
Susann Junker, Klaus W Frommer, Grit Krumbholz, Lali Tsiklauri, Rüdiger Gerstberger, Stefan Rehart, Jürgen Steinmeyer, Markus Rickert, Sabine Wenisch, Georg Schett, Ulf Müller-Ladner, Elena Neumann
OBJECTIVE: Osteophyte formation in osteoarthritis (OA) is mediated by increased osteoblast activity, which is -in turn- regulated by the Wnt signaling pathway. Obesity is regarded a risk factor in OA, yet little is known about the interaction between adipose tissue-derived factors, the adipokines, and bone formation, although adipokines are associated with the pathogenesis of OA. Therefore, the effect of adipokines on bone and cartilage forming cells and osteophyte development was analyzed...
November 21, 2016: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/27863927/concomitant-injury-of-the-annular-ligament-in-fractures-of-the-coronoid-process-and-the-supinator-crest
#8
Tim Leschinger, Lars Peter Müller, Michael Hackl, Martin Scaal, Kay Schmidt-Horlohé, Kilian Wegmann
BACKGROUND: Fractures of the coronoid process or the supinator crest, as well as arthroscopic resection of osteophytes around the coronoid process, can endanger the attachment of the annular ligament (AL) to the proximal ulna. The purpose of this study was to investigate the corresponding insertional areas of the AL within this context. METHODS: In 30 embalmed human cadaveric elbow specimens, the insertional area of the AL at the anterior and posterior margin of the sigmoid notch was characterized...
November 15, 2016: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/27863890/normal-values-of-cervical-vertebral-measurements-according-to-age-and-sex-in-ct
#9
Serhad Omercikoglu, Erhan Altunbas, Haldun Akoglu, Ozge Onur, Arzu Denizbasi
INTRODUCTION: Atlantodental interval (ADI), basion-dental interval (BDI) and the thickness of prevertebral soft tissue (TOPST) measured in lateral cervical radiographs were reported to be useful indicators and indirect signs of underlying cervical spine injuries. However, cervical computed tomography (MDCT) is the first method of imaging used in all trauma patients and upper normal limits (UNLs) of cervical distances according to age and sex are undetermined. Therefore, we aimed to calculate these metrics...
November 9, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27856294/role-of-the-c-c-chemokine-receptor-2-in-a-murine-model-of-injury-induced-osteoarthritis
#10
L Longobardi, J D Temple, L Tagliafierro, H Willcockson, A Esposito, N D'Onofrio, E Stein, T Li, T J Myers, H Ozkan, M L Balestrieri, V Ulici, R F Loeser, A Spagnoli
OBJECTIVE: We previously found in our embryonic studies that proper regulation of the chemokine CCL12 through its sole receptor CCR2, is critical for joint and growth plate development. In the present study, we examined the role of CCR2 in injury-induced-osteoarthritis (OA). METHOD: We used a murine model of injury-induced-OA (destabilization of medial meniscus, DMM), and systemically blocked CCR2 using a specific antagonist (RS504393) at different times during disease progression...
November 14, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27844478/erratum-osteophytes-may-be-a-rare-cause-of-recurrent-pleural-effusions
#11
K Psathakis, V Skouras, F Chatzivasiloglou, K Tsintiris
This corrects the article published on Monaldi Archives for Chest Disease 2013;79(2):87-89.
November 15, 2016: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/27832809/histological-evaluation-of-symptomatic-ossification-of-the-anterior-longitudinal-ligament-treated-with-etidronate-disodium-a-case-report
#12
Yusuke Sugimura, Naohisa Miyakoshi, Yuji Kasukawa, Michio Hongo, Yoichi Shimada
BACKGROUND: Here we report the first autopsied case involving pathological examination after two resections of symptomatic ossification of the anterior longitudinal ligament with anterior osteophytes and etidronate treatment with more than 8 years of follow-up. CASE PRESENTATION: A 51-year-old Japanese man complained of severe dysphagia due to esophageal compression by ossification of his anterior longitudinal ligament with anterior cervical osteophytes. Although surgical removal of the anterior cervical osteophytes was performed following etidronate treatment (800 mg/day for 6 months), dysphagia occurred secondary to recurrent ossification of his anterior longitudinal ligament with anterior osteophytes 7 years after the initial resection...
November 10, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27832771/semi-quantitative-mri-biomarkers-of-knee-osteoarthritis-progression-in-the-fnih-biomarkers-consortium-cohort%C3%A2-%C3%A2-methodologic-aspects-and-definition-of-change
#13
Frank W Roemer, Ali Guermazi, Jamie E Collins, Elena Losina, Michael C Nevitt, John A Lynch, Jeffrey N Katz, C Kent Kwoh, Virginia B Kraus, David J Hunter
BACKGROUND: To describe the scoring methodology and MRI assessments used to evaluate the cross-sectional features observed in cases and controls, to define change over time for different MRI features, and to report the extent of changes over a 24-month period in the Foundation for National Institutes of Health Osteoarthritis Biomarkers Consortium study nested within the larger Osteoarthritis Initiative (OAI) Study. METHODS: We conducted a nested case-control study...
November 10, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27830485/lateral-compartment-osteophytes-are-not-associated-with-lateral-compartment-cartilage-degeneration-in-arthritic-varus-knees
#14
Wenzel Waldstein, Maximilian F Kasparek, Martin Faschingbauer, Reinhard Windhager, Friedrich Boettner
BACKGROUND: Progression of arthritis in the lateral compartment is one of the main failure modes of unicompartmental knee arthroplasty (UKA). The decision regarding whether to perform a medial UKA sometimes is made based on whether lateral-compartment osteophytes are visible on plain radiographs obtained before surgery, but it is not clear whether the presence of lateral-compartment osteophytes signifies that the cartilage in the lateral compartment is arthritic. QUESTIONS/PURPOSES: (1) Is the presence of lateral compartment osteophytes associated with biomechanical properties of lateral-compartment cartilage, and (2) are osteophytes in the lateral compartment associated with particular histologic features of cartilage in the lateral compartment? METHODS: Between May 2010 and January 2012, we performed 201 TKAs for varus osteoarthritis confirmed on standardized AP hip-to-ankle standing radiographs...
November 9, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27829936/ultrasound-guided-arthroscopic-management-of-hallux-rigidus
#15
Łukasz M Paczesny, Jacek Kruczyński
INTRODUCTION: The use of metatarso-phalangeal joint arthroscopy in the treatment of osteochondritis dissecans was first described in 1988. The technique produces good results. However, it can be difficult to enter a joint when it is deformed by degenerative disease. Sonography is a modern visualisation modality which can be used in orthopaedic surgery. AIM: To describe a method of intraoperative sonographic navigation during first metatarso-phalangeal joint arthroscopy...
2016: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/27796082/pet-mri-of-metabolic-activity-in-osteoarthritis-a-feasibility-study
#16
Feliks Kogan, Audrey P Fan, Emily J McWalter, Edwin H G Oei, Andrew Quon, Garry E Gold
PURPOSE: To evaluate positron emission tomography / magnetic resonance imaging (PET/MRI) knee imaging to detect and characterize osseous metabolic abnormalities and correlate PET radiotracer uptake with osseous abnormalities and cartilage degeneration observed on MRI. MATERIALS AND METHODS: Both knees of 22 subjects with knee pain or injury were scanned at one timepoint, without gadolinium, on a hybrid 3.0T PET-MRI system following injection of (18) F-fluoride or (18) F-fluorodeoxyglucose (FDG)...
October 31, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27789465/systemic-inhibition-of-il-6-stat3-signalling-protects-against-experimental-osteoarthritis
#17
Augustin Latourte, Chahrazad Cherifi, Jérémy Maillet, Hang-Korng Ea, Wafa Bouaziz, Thomas Funck-Brentano, Martine Cohen-Solal, Eric Hay, Pascal Richette
OBJECTIVE: To investigate the impact of systemic inhibition of interleukin 6 (IL-6) or signal transducer and activator of transcription (Stat3) in an experimental model of osteoarthritis (OA). METHODS: Expression of major catabolic and anabolic factors of cartilage was determined in IL-6-treated mouse chondrocytes and cartilage explants. The anti-IL-6-receptor neutralising antibody MR16-1 was used in the destabilisation of the medial meniscus (DMM) mouse model of OA...
October 27, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27766035/dmp1-null-mice-develop-a-unique-osteoarthritis-like-phenotype
#18
Qi Zhang, Shuxian Lin, Ying Liu, Baozhi Yuan, Steph E Harris, Jian Q Feng
Patients with hypophosphatemia rickets (including DMP1 mutations) develop severe osteoarthritis (OA), although the mechanism is largely unknown. In this study, we first identified the expression of DMP1 in hypertrophic chondrocytes using immunohistochemistry (IHC) and X-gal analysis of Dmp1-knockout-lacZ-knockin heterozygous mice. Next, we characterized the OA-like phenotype in Dmp1 null mice from 7-week-old to one-year-old using multiple techniques, including X-ray, micro-CT, H&E staining, Goldner staining, scanning electronic microscopy, IHC assays, etc...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27759827/interobserver-reproducibility-of-radiographic-evaluation-of-lumbar-spine-instability
#19
Saulo de Tarso de Sá Pereira Segundo, Edgar Santiago Valesin, Mario Lenza, Durval do Carmo Barros Santos, Laercio Alberto Rosemberg, Mario Ferretti
Objective: To measure the interobserver reproducibility of the radiographic evaluation of lumbar spine instability. Methods: Measurements of the dynamic radiographs of the lumbar spine in lateral view were performed, evaluating the anterior translation and the angulation among the vertebral bodies. The tests were evaluated at workstations of the organization, through the Carestream Health Vue RIS (PACS), version 11.0.12.14 Inc. 2009© system. Results: Agreement in detecting cases of radiographic instability among the observers varied from 88...
July 2016: Einstein
https://www.readbyqxmd.com/read/27757376/bisphosphonates-therapy-for-osteoarthritis-a-meta-analysis-of-randomized-controlled-trials
#20
R L Xing, L R Zhao, P M Wang
High-turnover type bone metabolism derangement has been considered to be one of the major causes of osteoarthritis (OA). Bisphosphonates can attach to hydroxyapatite binding sites on bony surfaces, particularly those which are undergoing active bone resorption. To evaluate the effectiveness of bisphosphonates in OA treatment, literature databases were searched from inception to February 28, 2016 for clinical studies of bisphosphonates for OA treatment. All randomized controlled trials in which bisphosphonates therapy was compared with a placebo or a conventional medication, were selected...
2016: SpringerPlus
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