keyword
https://read.qxmd.com/read/38486437/anterior-cervical-osteophytes-a-rare-culprit-of-unilateral-vocal-cord-palsy
#1
Matthew Fadhil, Andrew Chun Lok Wong, Matthias Jaeger, Daniel Novakovic, Margaret Le Lacheur, Stuart MacKay
No abstract text is available yet for this article.
March 14, 2024: ANZ Journal of Surgery
https://read.qxmd.com/read/38484364/real-time-ultrasound-guided-posterolateral-thoracic-discectomy-2-dimensional-operative-video
#2
JOURNAL ARTICLE
Mohamed Macki, Timothy Chryssikos, Mahdi Saab, Lee Tan
Symptomatic thoracic disk herniations can be challenging to treat. Various surgical approaches have been reported in the literature, but the ideal approach is still a topic of controversy. We present a step-by-step surgical video highlighting the utilization of continuous, real-time intraoperative ultrasound (IOUS) guidance for thoracic discectomy through a posterolateral approach. The background and rationale for the procedure and a detailed presentation of the sequence of surgical steps are detailed in the operative video...
March 14, 2024: Operative Neurosurgery (Hagerstown, Md.)
https://read.qxmd.com/read/38483756/ilk-inhibition-reduces-osteophyte-formation-through-suppression-of-osteogenesis-in-bmscs-via-akt-gsk-3%C3%AE-%C3%AE-catenin-pathway
#3
JOURNAL ARTICLE
Zhixiang Huang, Lixin Huang, Jiali Ding, Yukai Huang, Xuechan Huang, Tianwang Li
BACKGROUND: Osteophyte development is a common characteristic of inflammatory skeletal diseases. Elevated osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) participates in pathological osteogenesis. Integrin-linked kinase (ILK) positively regulates the osteoblastic differentiation of osteoprogenitors, but whether the ILK blockage prevents osteophytes and its potential mechanism is still unknown. Furthermore, the low-dose tumor necrosis factor-α (TNF-α) promotes osteogenic differentiation, but a lack of study reports on the relationship between this cytokine and ILK...
March 14, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38472616/intraarticular-monomethyl-fumarate-as-a-perspective-therapy-for-osteoarthritis-by-macrophage-polarization
#4
JOURNAL ARTICLE
Douglas Menezes de Souza, Kauê Franco Malange, Catarine Massucato Nishijima, Bruno Henrique de Melo Lima, Vinicius Cooper Capetini, Alexandre L R de Oliveira, Gabriel Forato Anhê, Claudia Herrera Tambeli, Carlos Amilcar Parada
BACKGROUND: Osteoarthritis (OA) is a chronic disease that may lead to joint structure degeneration, cartilage destruction, osteophyte formation, subchondral bone disruption, and pain. In this scenario, a higher proportion of the proinflammatory macrophage type 1 (M1) than the anti-inflammatory macrophage type 2 (M2) could be highlighted as a hallmark of OA progression. The balance between these two macrophage types emerges as a new therapeutic target in OA. This study aimed to evaluate the analgesia and macrophage profile in the treatment of experimental osteoarthritis (EOA) with systemic dimethyl fumarate (DMF) or local intra-articular monomethyl fumarate (MMF)...
March 13, 2024: Inflammopharmacology
https://read.qxmd.com/read/38469555/ten-year-trends-in-values-of-joint-space-width-and-osteophyte-area-of-knee-joints-comparison-of-the-baseline-and-fourth-road-study-surveys
#5
JOURNAL ARTICLE
Banri Kitamura, Toshiko Iidaka, Chiaki Horii, Shigeyuki Muraki, Hiroyuki Oka, Hiroshi Kawaguchi, Kozo Nakamura, Toru Akune, Yuta Otsuka, Takayuki Izumo, Takao Tanaka, Tomohiro Rogi, Hiroshi Shibata, Sakae Tanaka, Noriko Yoshimura
OBJECTIVE: Considering the joint space width and osteophyte area (OPA) of the knee joints of Japanese adults, this study elucidated the ten-year trends in medial minimum joint space width (mJSW) and OPA using data of two independent cohorts from a population-based cohort study. METHODS: The baseline survey of the Research on Osteoarthritis/Osteoporosis Against Disability study was conducted from 2005 to 2007; 2975 participants (1041 men, 1934 women) completed all knee osteoarthritis (OA) examinations...
June 2024: Osteoarthritis and cartilage open
https://read.qxmd.com/read/38465899/urolithin-b-reduces-cartilage-degeneration-and-alleviates-osteoarthritis-by-inhibiting-inflammation
#6
JOURNAL ARTICLE
Hong Xue, Hongyu Zhou, Qiliang Lou, Putao Yuan, Zhenhua Feng, Li Qiao, Jiateng Zhang, Hongwei Xie, Yang Shen, Qingliang Ma, Shiyu Wang, Boya Zhang, Huali Ye, Jiao Cheng, Xuewu Sun, Peihua Shi
Osteoarthritis is the most prevalent degenerative joint disease reported worldwide. Conventional treatment strategies mainly focus on medication and involve surgical joint replacement. The use of these therapies is limited by gastrointestinal complications and the lifespan of joint prostheses. Hence, safe and efficacious drugs are urgently needed to impede the osteoarthritis progression. Urolithin B, a metabolite of ellagic acid in the gut, exhibits anti-inflammatory and antioxidant properties; however, its role in osteoarthritis remains unclear...
March 11, 2024: Food & Function
https://read.qxmd.com/read/38465033/double-trouble-a-case-report-of-a-locked-knee-due-to-a-loose-body-and-a-degenerative-osteophyte
#7
Muhammad Fadzil Salleh, Muhamad Karbela Reza Ramlan, Ahmad Farihan Mohd Don, Suria Hayati Md Pauzi, Badrul Akmal Hisham Md Yusoff
An acutely locked knee is an incapacitating condition that requires urgent orthopedic intervention. Common causes of the locked knee include a tear of the meniscus, stump of a ruptured anterior cruciate ligament (ACL), loose body, and osteochondral injury. This report describes a rare case of an acutely locked knee due to the concurrent presence of a loose body and a degenerative osteophyte, highlighting the diagnostic challenges and treatment strategies employed for successful management. Notably, to our knowledge, there is no preceding report documenting the same etiology...
February 2024: Curēus
https://read.qxmd.com/read/38462560/the-role-of-monocyte-macrophage-chemokines-in-pathogenesis-of-osteoarthritis-a-review
#8
REVIEW
Hao Luo, Linfeng Li, Song Han, Tao Liu
Osteoarthritis (OA) is one of the most common degenerative diseases characterised by joint pain, swelling and decreased mobility, with its main pathological features being articular synovitis, cartilage degeneration and osteophyte formation. Inflammatory cytokines and chemokines secreted by activated immunocytes can trigger various inflammatory and immune responses in articular cartilage and synovium, contributing to the genesis and development of OA. A series of monocyte/macrophage chemokines, including monocyte chemotaxis protein (MCP)-1/CCL2, MCP2/CCL8, macrophage inflammatory protein (MIP)-1α/CCL3, MIP-1β/CCL4, MIP-3α/CCL20, regulated upon activation, normal T-cell expressed and secreted /CCL5, CCL17 and macrophage-derived chemokine/CCL22, was proven to transmit cell signals by binding to G protein-coupled receptors on recipient cell surface, mediating and promoting inflammation in OA joints...
March 10, 2024: International Journal of Immunogenetics
https://read.qxmd.com/read/38440290/the-role-of-inflammatory-mediators-and-matrix-metalloproteinases-mmps-in-the-progression-of-osteoarthritis
#9
REVIEW
Anwesha Mukherjee, Bodhisatwa Das
Osteoarthritis (OA) is a chronic musculoskeletal disorder characterized by an imbalance between (synthesis) and catabolism (degradation) in altered homeostasis of articular cartilage mediated primarily by the innate immune system. OA degenerates the joints resulting in synovial hyperplasia, degradation of articular cartilage with damage of the structural and functional integrity of the cartilage extracellular matrix, subchondral sclerosis, osteophyte formation, and is characterized by chronic pain, stiffness, and loss of function...
March 2024: Biomater Biosyst
https://read.qxmd.com/read/38440110/injectable-nanocomposite-hydrogels-with-enhanced-lubrication-and-antioxidant-properties-for-the-treatment-of-osteoarthritis
#10
JOURNAL ARTICLE
Qizhu Chen, Yuxin Jin, Tao Chen, Hao Zhou, Xinzhou Wang, Ouqiang Wu, Linjie Chen, Zhiguang Zhang, Zhengyu Guo, Jin Sun, Aimin Wu, Qiuping Qian
Osteoarthritis (OA) is a chronic inflammatory joint disease characterized by progressive cartilage degeneration, synovitis, and osteoid formation. In order to effectively treat OA, it is important to block the harmful feedback caused by reactive oxygen species (ROS) produced during joint wear. To address this challenge, we have developed injectable nanocomposite hydrogels composed of polygallate-Mn (PGA-Mn) nanoparticles, oxidized sodium alginate, and gelatin. The inclusion of PGA-Mn not only enhances the mechanical strength of the biohydrogel through a Schiff base reaction with gelatin but also ensures efficient ROS scavenging ability...
April 2024: Materials today. Bio
https://read.qxmd.com/read/38436876/development-of-a-novel-animal-model-of-lumbar-vertebral-endplate-lesion-by-intervertebral-disk-injection-of-monosodium-iodoacetate-in-rats
#11
JOURNAL ARTICLE
Toshiaki Maruyama, Toshio Nakamae, Naosuke Kamei, Taiki Morisako, Kazuto Nakao, Fadlyansyah Farid, Hiroki Fukui, Nobuo Adachi
PURPOSE: Vertebral endplate lesions (EPLs) caused by severe disk degeneration are associated with low back pain. However, its pathophysiology remains unclear. In this study, we aimed to develop a vertebral EPL rat model mimicking severe intervertebral disk (IVD) degeneration by injecting monosodium iodoacetate (MIA) into the IVDs and evaluating it by assessing pain-related behavior, micro-computed tomography (CT) findings, and histological changes. METHODS: MIA was injected into the L4-5 and L5-6 IVDs of Sprague-Dawley rats...
March 4, 2024: European Spine Journal
https://read.qxmd.com/read/38432659/-recent-research-advances-of-angiogenesis-in-temporomandibular-joint-osteoarthritis
#12
JOURNAL ARTICLE
Z X Zheng, W Fang
Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease of temporomandibular joint, which has a high incidence and affects the quality of patients' life. While the pathogenesis of TMJOA remains unclear. It has been found that angiogenesis is involved in the development of TMJOA and it is closely related to the degradation of articular cartilage matrix, subchondral ossification, osteophyte formation and pain. This article reviews the recent advances in the study of angiogenesis in TMJOA, and provides a prospect for the treatment of TMJOA...
March 2, 2024: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://read.qxmd.com/read/38425836/detection-of-spondylosis-deformans-in-thoracolumbar-and-lumbar-lateral-x-ray-images-of-dogs-using-a-deep-learning-network
#13
JOURNAL ARTICLE
Junseol Park, Hyunwoo Cho, Yewon Ji, Kichang Lee, Hakyoung Yoon
INTRODUCTION: Spondylosis deformans is a non-inflammatory osteophytic reaction that develops to re-establish the stability of weakened joints between intervertebral discs. However, assessing these changes using radiography is subjective and difficult. In human medicine, attempts have been made to use artificial intelligence to accurately diagnose difficult and ambiguous diseases in medical imaging. Deep learning, a form of artificial intelligence, is most commonly used in medical imaging data analysis...
2024: Frontiers in Veterinary Science
https://read.qxmd.com/read/38422741/the-effects-of-combined-and-independent-low-level-laser-and-mesenchymal-stem-cell-therapy-on-induced-knee-osteoarthritis-an-animal-study
#14
JOURNAL ARTICLE
Nader Tanideh, Mohammad Ali Behnam, Sheida Mohit Ghiri, Omid Koohi-Hosseinabadi, Hossein Khajeh-Zadeh, Shahrokh Zare, Negar Azarpira, Armin Akbarzadeh, Soheil Ashkani-Esfahani, Alireza Ebrahimi, Adrina Habibzadeh
BACKGROUND: Mesenchymal stem cell (MSC) injection has emerged as a novel treatment for knee osteoarthritis (OA). In addition, low-level laser therapy (LLLT) has been reported to delay the progression of OA. Thus, the current study on animal models of OA investigated the effectiveness of these methods when administered independently and combined. METHODS: Twenty-five guinea pig models of OA were randomly sorted into five study groups. The test groups received intra-articular MSC, LLLT, and a combination of these therapeutics for 8 weeks...
February 28, 2024: Knee
https://read.qxmd.com/read/38421679/morphological-and-quantitative-parametric-mri-follow-up-of-cartilage-changes-before-and-after-intra-articular-injection-therapy-in-patients-with-mild-to-moderate-knee-osteoarthritis-a-randomized-placebo-controlled-trial
#15
JOURNAL ARTICLE
Marcel Tschopp, Christian W A Pfirrmann, Florian Brunner, Sandro F Fucentese, Julien Galley, Christoph Stern, Reto Sutter, Sabrina Catanzaro, Nathalie Kühne, Andrea B Rosskopf
BACKGROUND: Intra-articular injections are routinely used for conservative treatment of knee osteoarthritis (OA). The detailed comparative therapeutic effects of these injections on cartilage tissue are still unclear. OBJECTIVE: The aim of this study was to detect and compare knee cartilage changes after intra-articular injection of glucocorticoid, hyaluronic acid, or platelet-rich plasma (PRP) to placebo using quantitative (T2 and T2* mapping) and morphological magnetic resonance imaging parameters in patients with mild or moderate osteoarthritis...
February 28, 2024: Investigative Radiology
https://read.qxmd.com/read/38420736/the-value-of-computed-tomography-scan-in-three-dimensional-planning-and-intraoperative-navigation-in-primary-total-hip-arthroplasty
#16
REVIEW
Fabio Mancino, Andreas Fontalis, Ahmed Magan, Ricci Plastow, Fares S Haddad
Total hip arthroplasty (THA) is a frequently performed procedure; the objective is restoration of native hip biomechanics and achieving functional range of motion (ROM) through precise positioning of the prosthetic components. Advanced three-dimensional (3D) imaging and computed tomography (CT)-based navigation are valuable tools in both the preoperative planning and intraoperative execution. The aim of this study is to provide a thorough overview on the applications of CT scans in both the preoperative and intraoperative settings of primary THA...
March 1, 2024: Hip & Pelvis
https://read.qxmd.com/read/38418169/-study-on-the-mechanism-of-cross-linked-hyaluronic-acid-dexamethasone-hydrogelin-post-traumatic-osteoarthritis
#17
JOURNAL ARTICLE
Z W Zhang, J Y Zhao, Y Feng, K Yin, P C Li, X C Wei
Objective: To explore the mechanism of cross-linked hyaluronic acid-dexamethasone hydrogel (cHA-Dex) in inhibiting chondrocyte apoptosis and alleviating early post-traumatic osteoarthritis (PTOA). Methods: To generate PTOA model, anterior cruciate ligament transection (ACLT)was performed on SD rats ( n =70), and the sham surgery group ( n =70) was set as control. The changes in inflammatory indicators such as interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), matrix metalloproteinase-3 (MMP-3), and matrix metalloproteinase-13 (MMP-13) in the joint lavage fluid were measured at different time points (1-14 days, 5 rats at each time point) after surgery...
March 5, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38417620/prevalence-features-and-predictive-factors-of-spontaneous-spinal-arthrodesis-in-post-traumatic-thoracolumbar-kyphosis
#18
JOURNAL ARTICLE
Jincheng Liu, Xiaofei Zhang, Hao Zhang, Jian Zhang, Qing Wang, Guangzhou Li
OBJECTIVE: Spontaneous spinal arthrodesis (SSA) is a phenomenon of spontaneous fusion, and SSA is not rare in post-traumatic thoracolumbar kyphosis (PTK). However, few reports have focused on SSA in patients with PTK. The objective of this study was to investigate the prevalence, features and predictive factors of SSA in PTK patients. METHODS: In this retrospective study, 70 patients with PTK were included. Data on the clinical and radiological parameters were obtained and evaluated...
February 26, 2024: World Neurosurgery
https://read.qxmd.com/read/38410163/one-step-stromal-vascular-fraction-therapy-in-osteoarthritis-with-tropoelastin-enhanced-autologous-stromal-vascular-fraction-gel
#19
JOURNAL ARTICLE
Junjun Yang, Xin Wang, XueBao Zeng, Rong Wang, Yanming Ma, Zhenlan Fu, Zu Wan, Zhi Wang, Liu Yang, Guangxing Chen, Xiaoyuan Gong
Background: Osteoarthritis (OA) is a debilitating degenerative joint disease, leading to significant pain and disability. Despite advancements, current regenerative therapies, such as mesenchymal stem cells (MSCs), face challenges in clinical efficacy and ethical considerations. This study aimed to evaluate the therapeutic potential of stromal vascular fraction gel (SVF-gel) in comparison to available treatments like hyaluronic acid (HA) and adipose-derived stem cells (ADSCs) and to assess the enhancement of this potential by incorporating tropoelastin (TE)...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38409922/small-medial-proximal-tibial-angle-is-a-radiographic-finding-strongly-associated-with-less-coronal-alignment-correction-under-valgus-stress-in-medial-knee-osteoarthritis
#20
JOURNAL ARTICLE
Kazuki Ichiyanagi, Shinichi Kuriyama, Sayako Sakai, Takahiro Maeda, Yusuke Yamawaki, Kohei Nishitani, Shinichiro Nakamura, Shuichi Matsuda
PURPOSE: The degree to which varus knees can be corrected manually is important when considering total versus unicompartmental knee arthroplasty (UKA). The primary aim was to clarify the relationship between the degree of coronal alignment correction and radiographic parameters involved in UKA prognosis using preoperative full-length lower extremity valgus stress radiography. The secondary aim was to identify the factors affecting alignment correction. METHODS: This retrospective observational study included 115 knees with medial osteoarthritis that underwent knee osteotomy or arthroplasty...
February 26, 2024: Knee Surgery, Sports Traumatology, Arthroscopy
keyword
keyword
51898
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.