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https://www.readbyqxmd.com/read/29772342/is-local-or-central-adiposity-more-strongly-associated-with-incident-knee-osteoarthritis-than-the-body-mass-index-in-men-or-women
#1
Adam G Culvenor, David T Felson, Wolfgang Wirth, Torben Dannhauer, Felix Eckstein
OBJECTIVE: To determine whether central (abdominal) or peripheral (thigh) adiposity measures are associated with incident radiographic knee osteoarthritis (RKOA) independent of body mass index (BMI) and whether their relation to RKOA was stronger than that of BMI. DESIGN: 161 Osteoarthritis Initiative participants (62% female) with incident RKOA (Kellgren/Lawrence grade 0/1 at baseline, developing an osteophyte and joint space narrowing grade ≥1 by year-4) were matched to 186 controls (58% female) without incident RKOA...
May 14, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29772032/prevalence-of-abnormal-morphology-of-the-temporomandibular-joint-in-asymptomatic-subjects-a-retrospective-cohort-study-utilizing-cone-beam-computed-tomography
#2
Thiago Azário de Holanda, Rita Cássia de Almeida, Alexandre Emídio Silva, Melissa Feres Damian, Noéli Boscato
PURPOSE: This retrospective cohort study in an asymptomatic nonpatient population evaluated the prevalence of specific morphologic changes usually associated with the presence of degenerative joint diseases (DJD) using cone beam computed tomography (CBCT) and examined the associations between DJD and age, sex, and number of teeth present. MATERIALS AND METHODS: CBCT images (268 TMJs) of 134 asymptomatic patients were studied. Patient data were obtained from clinical records, and calibrated examiners interpreted the CBCT images...
May 17, 2018: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/29746921/anatomical-study-of-the-first-dorsal-extensor-compartment-for-the-treatment-of-de-quervain-s-disease
#3
Yong Seok Nam, GyeongHyeon Doh, Ki Yong Hong, SooA Lim, SuRak Eo
INTRODUCTION: Anatomical variations of the first dorsal extensor compartment (1st EC) are commonly noted. MATERIALS AND METHODS: Forty cadaver hands were dissected to define the 1st EC. Through the gross findings, we classified the contents according to the presence of septation, subcompartment, and variation of tendons. Bony cross-section of the wrist was performed to reveal any bony pattern within the 1st EC. We also measured the anatomical structures of the 1st EC...
May 7, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29741735/widespread-epigenomic-transcriptomic-and-proteomic-differences-between-hip-osteophytic-and-articular-chondrocytes-in-osteoarthritis
#4
Julia Steinberg, Roger A Brooks, Lorraine Southam, Sahir Bhatnagar, Theodoros I Roumeliotis, Konstantinos Hatzikotoulas, Eleni Zengini, J Mark Wilkinson, Jyoti S Choudhary, Andrew W McCaskie, Eleftheria Zeggini
Objectives: To identify molecular differences between chondrocytes from osteophytic and articular cartilage tissue from OA patients. Methods: We investigated genes and pathways by combining genome-wide DNA methylation, RNA sequencing and quantitative proteomics in isolated primary chondrocytes from the cartilaginous layer of osteophytes and matched areas of low- and high-grade articular cartilage across nine patients with OA undergoing hip replacement surgery. Results: Chondrocytes from osteophytic cartilage showed widespread differences to low-grade articular cartilage chondrocytes...
May 8, 2018: Rheumatology
https://www.readbyqxmd.com/read/29740589/cervical-hyperostosis-leading-to-dyspnea-aspiration-and-dysphagia-strategies-to-improve-patient-management
#5
Georgios Psychogios, Monika Jering, Johannes Zenk
Diffuse idiopathic skeletal hyperostosis (DISH) is a rare but well known cause of dysphagia. In very few cases aspiration and dyspnea are described as a clinical manifestation. An 82-year-old man presented himself in our clinic with severe dyspnea, aspiration, and pneumonia. After performing a microlaryngoscopy an emergency tracheotomy became necessary. In laryngoscopy a severe bulging of the posterior oropharyngeal and hypopharyngeal wall was detected. The glottis area was not observable and immobilisation of the right vocal cord could be detected...
2018: Frontiers in Surgery
https://www.readbyqxmd.com/read/29738991/digital-tracking-algorithm-reveals-the-influence-of-structural-irregularities-on-joint-movements-in-the-human-cervical-spine
#6
Christian Balkovec, Jim Veldhuis, John W Baird, G Wayne Brodland, Stuart M McGill
BACKGROUND: Disc height loss and osteophytes change the local mechanical environment in the spine; while previous research has examined kinematic dysfunction under degenerative change, none has looked at the influence of disc height loss and osteophytes throughout movement. METHODS: Twenty patients with pain related to the head, neck or shoulders were imaged via videofluoroscopy as they underwent sagittal-plane flexion and extension. A clinician graded disc height loss and osteophytes as "severe/moderate", "mild", or "none"...
April 26, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29738676/anterior-cruciate-ligament-tibial-footprint-size-as-measured-on-magnetic-resonance-imaging-does-it-reliably-predict-actual-size
#7
Seong Hwan Kim, Han-Jun Lee, Yong-Beom Park, Han-Sol Jeong, Chul-Won Ha
BACKGROUND: Measuring the size of the anterior cruciate ligament (ACL) tibial footprint on magnetic resonance image (MRI) is common for preoperative planning of ACL reconstruction. However, the accuracy of such measurement has not been well documented. PURPOSE: To investigate whether the actual size of the ACL tibial footprint could be predicted by its measurement on MRI and to develop equations to improve the accuracy of predicting the actual size based on MRI measurement...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29736207/interleukin-6-from-subchondral-bone-mesenchymal-stem-cells-contributes-to-the-pathological-phenotypes-of-experimental-osteoarthritis
#8
Xiaofeng Wu, Lei Cao, Fan Li, Chao Ma, Guangwang Liu, Qiugen Wang
As a main cause of morbidity in the aged population, osteoarthritis (OA) is characterized by cartilage destruction, synovium inflammation, osteophytes, and subchondral bone sclerosis. To date its etiology remains elusive. Recent data highlight an important role of subchondral bone in the onset and progression of OA. Therefore, elucidating the mechanisms underlying abnormal subchondral bone could be of importance in the treatment of OA. Interleukin-6 is a proinflammatory cytokine involved in many physiological and pathological processes...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29729497/can-osteophytes-be-used-as-age-at-death-estimators-testing-correlations-in-skeletonized-human-remains-with-known-age-at-death
#9
Francisca Alves-Cardoso, Sandra Assis
Age-at-death estimation is one of the major challenges when establishing an adult skeleton biological profile. The presence of degenerative joint changes - e.g. osteophytes - has been regarded as a good postmaturity age indicator. This study assessed if a clear relationship between age and osteophytes exists. To accomplish this goal, a total of 16 joint surfaces, from the shoulder, elbow, wrist, hip, knee, and ankle, were examined in 604 adult individuals, of both sexes from two Portuguese Identified collections...
April 22, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29728409/subchondral-drilling-for-articular-cartilage-repair-a-systematic-review-of-translational-research
#10
Liang Gao, Lars K H Goebel, Patrick Orth, Magali Cucchiarini, Henning Madry
Articular cartilage defects may initiate osteoarthritis. Subchondral drilling, a widely applied clinical technique to treat small cartilage defects, does not yield cartilage regeneration. Various translational studies aiming to improve the outcome of drilling have been performed, however, a robust systematic analysis of its translational evidence has been still lacking. Here, we performed a systematic review of the outcome of subchondral drilling for knee cartilage repair in translational animal models. A total of 12 relevant publications studying 198 animals were identified, detailed study characteristics were extracted, and methodological quality and risk of bias were analyzed...
May 3, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29723633/associations-between-the-chemokine-biomarker-ccl2-and-knee-osteoarthritis-outcomes-the-johnston-county-osteoarthritis-project
#11
Lara Longobardi, Joanne M Jordan, Xiaoyan A Shi, Jordan B Renner, Todd A Schwartz, Amanda E Nelson, David A Barrow, Virginia B Kraus, Anna Spagnoli
OBJECTIVE: Our study analyzes the association between chemokine-ligand-2 (CCL2) serum concentrations at baseline and knee radiographic OA (knee-rOA), knee-rOA progression, individual radiographic features and knee symptomatic OA at 5-year follow-up. DESIGN: OA outcomes were analyzed in a community-based cohort including a baseline enrollment and a 5-year follow-up. Baseline CCL2 serum concentrations were assessed by multiplex assay and associated with presence or progression of individual radiographic features at 5-year follow-up...
April 30, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29720262/upper-zone-of-growth-plate-and-cartilage-matrix-associated-protein-protects-cartilage-during-inflammatory-arthritis
#12
Fritz Seuffert, Daniela Weidner, Wolfgang Baum, Georg Schett, Michael Stock
BACKGROUND: ADAMTS aggrecanases play a major role in cartilage degeneration during degenerative and inflammatory arthritis. The cartilage-specific secreted protein Upper zone of growth plate and cartilage matrix associated protein (Ucma) has been shown to block ADAMTS-triggered aggrecanolysis in experimental osteoarthritis. Here we aimed to investigate whether and how Ucma may affect cartilage destruction and osteophyte formation in the context of inflammatory arthritis. METHODS: Ucma-ADAMTS5 protein interactions were studied using slot blot and solid phase binding assays...
May 2, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29713775/tibial-tuberosity-to-trochlear-groove-distance-and-its-association-with-patellofemoral-osteoarthritis-related-structural-damage-worsening-data-from-the-osteoarthritis-initiative
#13
Arya Haj-Mirzaian, Ali Guermazi, Michael Hakky, Christopher Sereni, Bashir Zikria, Frank W Roemer, Miho J Tanaka, Andrew J Cosgarea, Shadpour Demehri
OBJECTIVES: To determine whether the tibial tuberosity-to-trochlear groove (TT-TG) distance is associated with concurrent patellofemoral joint osteoarthritis (OA)-related structural damage and its worsening on 24-month follow-up magnetic resonance imaging (MRI) in participants in the Osteoarthritis Initiative (OAI). METHODS: Six hundred subjects (one index knee per participant) were assessed. To evaluate patellofemoral OA-related structural damage, baseline and 24-month semiquantitative MRI Osteoarthritis Knee Score (MOAKS) variables for cartilage defects, bone marrow lesions (BMLs), osteophytes, effusion, and synovitis were extracted from available readings...
April 30, 2018: European Radiology
https://www.readbyqxmd.com/read/29709499/in-thumb-base-osteoarthritis-structural-damage-is-more-strongly-associated-with-pain-than-synovitis
#14
Féline P B Kroon, Sjoerd van Beest, Selime Ermurat, Marion C Kortekaas, Johan L Bloem, Monique Reijnierse, Frits R Rosendaal, Margreet Kloppenburg
OBJECTIVE: Osteoarthritis in thumb base joints (first carpometacarpal (CMC-1), scaphotrapeziotrapezoid (STT)) is prevalent and disabling, yet focussed studies are scarce. Our aim was to investigate associations between ultrasonographic and magnetic resonance imaging (MRI) inflammatory features, radiographic osteophytes, and thumb base pain in hand osteoarthritis patients. DESIGN: Cross-sectional analyses were performed in cohorts with MRI (n=202) and ultrasound measurements (n=87)...
April 27, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29705812/imaging-assisted-diagnosis-and-characteristics-of-suspected-spinal-brucellosis-a-retrospective-study-of-72-cases
#15
Laiyong Tu, Xinmei Liu, Wenfei Gu, Zhenbin Wang, Enfeng Zhang, Aikenmu Kahar, Ge Chu, Jiang Zhao
BACKGROUND We clarified the imaging features of Brucella spondylitis to enhance our understanding of the disease and to minimize misdiagnosis. MATERIAL AND METHODS Imaging data (X-ray, computed tomography [CT], and magnetic resonance imaging [MRI] data) of 72 Brucella spondylitis patients treated from 2010 to 2017 were retrospectively analyzed; diagnoses was made by evaluating laboratory and pathological data. RESULTS X-ray films revealed changes in intervertebral space heights, the number of lateral osteophytes, and bone destruction, which were more severe in the following order: lumbosacral vertebrae (56 cases, 77...
April 29, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29703029/attrition-rupture-of-ulnar-nerve-in-a-patient-with-rheumatoid-elbow-arthritis-a-case-report
#16
Ayaka Kaneko, Yoichi Sugiyama, Nana Nagura, Kenji Goto, Yoshiyuki Iwase, Osamu Obayashi, Kiyohito Naito, Kazuo Kaneko
RATIONALE: Cubital tunnel syndrome has been recognized as a common pathology in rheumatoid arthritis (RA) of the elbow. We encountered a patient with RA of the elbow showing attrition rupture of the ulnar nerve. This pathology is extremely rare, and we discussed preventive measures for similar cases in the future based on our case. PATIENT CONCERNS: A 53-year-old woman, received drug treatment for RA since 30 years earlier, had numbness in the left ulnar nerve territory, dorsal interossei muscle atrophy, and resulting claw hand...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29697716/prevalence-of-posterior-disc-displacement-of-the-temporomandibular-joint-in-patients-with-temporomandibular-disorders-systematic-review-and-meta-analyses
#17
Shaista Afroz, Mio Naritani, Hidehiko Hosoki, Kenshi Takechi, Yoshihiro Okayama, Yoshizo Matsuka
AIMS: To assess the prevalence of posterior disc displacement (PDD) in patients with temporomandibular disorders (TMD) through a systematic review of the literature and meta-analysis, as well as to assess features associated with PDD such as chief complaint, signs and symptoms, morphologic condyle and disc alterations, and PDD management. METHODS: A systematic literature search was performed in the US National Library of Medicine's PubMed/MEDLINE and Cochrane Library databases to identify all peer-reviewed, English-language manuscripts related to PDD...
April 25, 2018: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29696322/-minimally-invasive-cheilectomy
#18
REVIEW
M Walther, P Chomej, S Kriegelstein, S Altenberger, A Röser
OBJECTIVES: Treatment of hallux rigidus by minimally invasive resection of the dorsal osteophytes, synovectomy and resection of the dorsal part of the metatarsal head. INDICATIONS: Hallux rigidus grades II and III CONTRAINDICATIONS: End-stage osteoarthritis of the first metatarsophalangeal joint with beginning ankylosis. SURGICAL TECHNIQUE: Osteophytes around the metatarsophalangeal joint are removed using a 1 cm incision dorsomedial, approximately 3 cm proximal of the joint space...
April 25, 2018: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/29692195/exosomes-and-stem-cells-in-degenerative-disease-diagnosis-and-therapy
#19
Yu-Hsun Chang, Kung-Chi Wu, Horng-Jyh Harn, Shinn-Zong Lin, Dah-Ching Ding
Stroke can cause death and disability, resulting in a huge burden on society. Parkinson's disease (PD) is a chronic neurodegenerative disorder characterized by motor dysfunction. Osteoarthritis (OA) is a progressive degenerative joint disease characterized by cartilage destruction and osteophyte formation in the joints. Stem cell therapy may provide a biological treatment alternative to traditional pharmacological therapy. Mesenchymal stem cells (MSCs) are preferred because of their differentiation ability and possible derivation from many adult tissues...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29688066/high-field-structural-mri-in-the-management-of-degenerative-cervical-myelopathy
#20
Dan Wright, Sean Martin, Erlick Ac Pereira, Yazhuo Kong, Irene Tracey, Thomas Cadoux-Hudson
INTRODUCTION: This is a narrative overview of the pathophysiology, investigation and management of Degenerative Cervical Myelopathy (DCM). This review article also takes a look ahead to the impact high resolution MRI may have on treatment. BACKGROUND: DCM is the most common cause of spinal dysfunction and yet it remains poorly understood. It is becoming increasingly common in our ageing population. Disc and facet joint abnormalities, osteophytes, spondylothisthesis and ligamentous hypertrophy all act together to produce spinal canal and neuronal foramina stenosis which in turn causes neural compromise...
April 24, 2018: British Journal of Neurosurgery
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